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- Product number
- 25859-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#25859-1-AP, RRID:AB_2716568
- Product name
- TH antibody
- Antibody type
- Polyclonal
- Description
- TH antibody (Cat. #25859-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Enhancing oligodendrocytes generation and myelin renewal by vitamin C mitigate Parkinson-relevant phenotypes in a murine model of Parkinson's disease.
Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis.
Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ's neuroprotection in Parkinson's disease.
Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH/NLRP3 Inflammasome pathway.
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
Hypothalamic PVH Tyrosine Hydroxylase-Positive (Predominantly Dopaminergic) Neurons Mediate the Bidirectional Control of Neuropathic Pain and Comorbid Memory Impairments.
Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.
Cardiac-specific sympathetic modulation, not splenic innervation, mediates PC6 electroacupuncture-induced cardioprotection via M2 macrophage polarization in mice with acute myocardial infarction.
Impact of NPAS2 on mPFC dopamine synthesis and nap behavior.
Evodiamine alleviates MPTP-induced Parkinson's disease in mice by regulating gut microbiota and suppressing TLR4/MyD88/NF-kB pathway.
Protein Modifications and Metabolic Alterations in the Rat Striatum Following Oil Mist Particulate Matter Exposure Revealed via Untargeted Metabolomics and Phosphoproteomics.
RELA as a Diagnostic Biomarker for Parkinson's Disease by Integrating Ferroptosis, Lipid Metabolism, and Neuroinflammation.
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson's disease.
Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice.
Stress-Induced Activation of Prolactin-NR4A1-Midkine Axis Exacerbates Skin Inflammation.
Low-dose ciprofol attenuates motor dysfunction in PD mice by inhibiting NLRP3 inflammasome activation.
Activation of LH orexin neurons and VTA dopamine neurons is involved in anesthesia/surgery-induced sleep-wake disorders and delirium-like behaviors in mice.
Multisensory integration in the mouse ventral visual thalamus mediates stress coping via locus coeruleus-related circuits.
Butyrate-Modified Hyaluronic Acid Ameliorates MPTP-Induced Parkinson's Disease via Modulating PINK1/Parkin-Involved Mitophagy and Intestinal Flora.
Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood-brain barrier.
SIX2-Mediated Microglial M2 Polarization and Exosomal miR-3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease.
The Kv4.3 channel on c-low threshold mechanoreceptors in DRG is a key mediator transforming tactile stimuli into nociceptive signals in chemotherapy-induced neuropathy.
Reducing Neuroinflammation via Inhibition of Fibrinogen Deposition and Microglial Activation as an Underlying Mechanism of Paning I Decoction in Ameliorating Parkinson's Disease Symptoms.
From Kitchen Spice to Neuroprotector: The Role of 6-Shogaol in Parkinson's Disease Management.
FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
High-Resolution 3D reconstruction and visualization of normal adrenal vasculature and sympathetic nerves in mice.
Mitochondrial DNA drives NLRP3-IL-1β axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models.
Chloride intracellular channel 4 contributes to Aβ-induced cognitive impairment in mice through the regulation of mitochondrial fission. CLIC4 promotes mitochondrial fission.
Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies.
Sympathetic denervation alters pulmonary microbiota diversity and composition in mice.
Regulation of short-term declarative memory by selective activation of the locus coeruleus-retrosplenial cortex dopaminergic pathway and its pathological alterations in Parkinson's disease.
Transcranial magneto-acoustic stimulation improves corticostriatal transmission in direct medium spiny neurons and rescues neuroplasticity of Parkinson's disease model mice.
Single-Cell Profiling Identifies Reward Behavior-Related Neurons and Alterations in the Ventral Tegmental Area Based on Arvcf-Knockout Mouse Model.
Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics.
Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Coixol ameliorates dopaminergic neurodegeneration by inhibiting neuroinflammation and protecting mitochondrial function.
(18)F-DOPA uptake illustration acts as an indicator for renal sympathetic activity.
Mechanism of Tourette Syndrome Induced by ABGA-Mediated CaMKII-TH Pathway.
Celastrol protected the MPTP-injected mice Parkinson's disease model via redox regulation of CDC37.
Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1α pathway.
Neurotoxicity of chronic nano-neodymium oxide exposure in zebrafish: Behavioral and molecular insights.
Artemisinin alleviates Parkinson's disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats.
Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson's disease.
Biomimetic Nanoregulators Mediated Tyrosine Hydroxylase mRNA and Stimulator of Interferon Genes Antagonist Codelivery for Synergistic Therapy on Parkinson's Disease.
Ginsenoside Rk3 Alleviates Neuroinflammation and Gastrointestinal Dysfunction in Parkinson's Disease via Modulation of Gut Microbiota-Mediated Butyric Acid Metabolism.
Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson's Disease Model: Transcriptomic Evidence.
Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways.
LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson's Disease.
SIRT1 Expression in Human Gastrointestinal Tumors and Its Clinical Significance.
Overexpression of Rap1B alleviate central precocious puberty and neurodevelopmental damage.
Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis-Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis.
PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson's disease.
P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP(+)/MPTP-induced Parkinson's disease.
The Identification and Synthesis of New Sea Cucumber Peptides Leveraging Peptidomics Technology, along with their Anti-Parkinson's Disease Efficacy.
Sodium Para-Aminosalicylic Acid Inhibits Manganese-Iron Co-exposure-induced Inflammation via the NF-κB Pathway in Rat Substantia Nigra.
Tyrosine hydroxylase-expressing neurons in the paraventricular nucleus of the hypothalamus regulate peripheral leukocytes during inflammatory pain.
Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning.
Pyridoxal phosphate inhibits alpha-synuclein-induced ferroptosis by activating GOT1 to enhance the methionine salvage pathway in Parkinson's disease.
Carvedilol Confers Neuroprotective Activity Through Modulating Ferroptosis Key Players and PINK1/PARKIN Mediated Mitophagy in an Experimental Parkinson's Rat Model.
Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson's Disease.
The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice.
Short-Chain Fatty Acids Enhance EAAT2-Mediated Glutamate Clearance and Alleviate Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease.
Noradrenergic α(2) Receptor Modulates Cav2.2-Mediated Nociception in Parkinson's Disease Through Spinal Neuro-glial Network.
GLP-1/GIP dual agonist tirzepatide alleviates mice model of Parkinson's disease by promoting mitochondrial homeostasis.
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Pharmacological and electrophysiological characterization of the novel Kv7 channel inhibitor racecadotril in Parkinson's disease.
Remote ischemic conditioning as a potential therapy for Parkinson's Disease: Inhibiting TLR4-Driven neuroinflammation and oxidative damage.
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.
Aromatherapy With Nardostachys Jatamansi DC. Essential Oil Targeting the MAOA Gene Regulates Cardiac Neural Remodeling and Amino Acid Metabolism to Alleviate Sleep Deprivation-Induced Myocardial Injury.
Inhalation of Acori Tatarinowii Rhizoma essential oil alleviates dyskinesia in Parkinson's disease rats through the regulation of neuroinflammation.
Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson's disease.
Endosomal protein DENND10 promotes developmental competence of neurite extension.
Revealing the therapeutic targets, mechanisms, and heterogeneity of Huatan Jieyu Granules for Parkinson's disease through single-cell sequencing.
Nerve infiltration of bladder cancer predicts response to immunotherapy.
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice.
Identification and validation of Atp5f1c in CD4(+) T cell as a hub protein in Parkinson's disease.
Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy.
Effects of moderate static magnetic fields on voltage-gated potassium ion channels in sympathetic neuron-like PC12 cells.
The ARC(CRABP1) neurons play a crucial role in the regulation of energy homeostasis.
SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota.
Transcranial magneto-acoustic stimulation enhances motor function and modulates cortical excitability of motor cortex in a Parkinson's disease mouse model.
Cholesterol promotes hair growth through activating sympathetic nerves and enhancing the proliferation of hair follicle stem cells.
Corilagin Attenuates Neuronal Apoptosis and Ferroptosis of Parkinson's Disease through Regulating the TLR4/Src/NOX2 Signaling Pathway.
Investigating the effect of Arvcf reveals an essential role on regulating the mesolimbic dopamine signaling-mediated nicotine reward.
Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.
Ceftriaxone affects ferroptosis and alleviates glial cell activation in Parkinson's disease.
DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson's disease vulnerability.
Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells.
Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway.
Erzhi pill promotes norepinephrine synthesis in locus coeruleus through ERβ-TFAP2A-TH plays a neuroprotective role.
Saponins from Panax japonicus Enhance Lipolysis via Acting on FGF21-β-Klotho/FGFR1 in Obese Mice.
Theta oscillation synchronize VTA and mPFC during ethanol-induced conditioned place preference and stress-evoked anxiety.
Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
Lamellar Schwann cells in the Pacinian corpuscle potentiate vibration perception.
Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson's disease through integrative multi-omics analysis.
Narirutin reduces microglia-mediated neuroinflammation by inhibiting the JAK2/STAT3 pathway in MPP(+)/MPTP-induced Parkinson's disease models.
Hyperglycemia Aggravates 6-Hydroxydopamine-Induced Neuronal Ferroptosis via SLC7A11-Dependent Pathway in Diabetic PD Rat Model.
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Dopamine Alleviated Diabetic Retinal Neurodegeneration through Protecting Retinal Ganglion Cells from Ferroptosis via the Nrf2/HO‑1 Signaling Pathway.
Comparison of Two MPTP Doses on Mouse Behaviors and Pathologies.
Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye.
Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway.
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.
Astrocyte-neuron communication through the complement C3-C3aR pathway in Parkinson's disease.
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.
OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease.
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
CAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness.
VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice.
PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology.
Garlic-Derived Allicin Attenuates Parkinson's Disease via PKA/p-CREB/BDNF/DAT Pathway Activation and Apoptotic Inhibition.
Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease.
Behavioral, biochemical, and molecular characterization of MPTP/p-intoxicated mice.
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Akkermansia muciniphila protects against dopamine neurotoxicity by modulating butyrate to inhibit microglia-mediated neuroinflammation.
Electroacupuncture Improves Cardiac Function via Inhibiting Sympathetic Remodeling Mediated by Promoting Macrophage M2 Polarization in Myocardial Infarction Mice.
Targeted Liposomal Co-Delivery Dopamine with 3-n-Butylphthalide for Effective Against Parkinson's Disease in Mice Model.
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Cardiac sympathetic overdrive, M2 macrophage activation and fibroblast heterogeneity are associated with cardiac remodeling in a chronic pressure overload rat model of HFpEF.
Electroacupuncture Alleviates Obesity and Insulin Resistance via the GLP-1-VTADA Reward Circuit.
NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Catecholamines-based myocardial injury after acute ischemic stroke and effects of Naoxintong capsule therapy.
Therapeutic potential of Canna edulis RS3-resistant starch in alleviating neuroinflammation and apoptosis in a Parkinson's disease rat model.
Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells.
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson's disease: association with peripheral inflammatory regulatory T-cells and SYT6.
Dorsal raphe dopaminergic neurons target CaMKII(+) neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors.
S-(N,N-diethyldithiocarbamoyl)-N-acetyl-l-cysteine for the treatment of non-small cell lung cancer through regulating NF-κB signalling pathway without neurotoxicity.
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa-induced dyskinesia in a mouse model of Parkinson's disease.
Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson's and Alzheimer's disease co-pathology and behavior impairments.
Identifying genetic targets in clinical subtypes of Parkinson's disease for optimizing pharmacological treatment strategies.
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways.
LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
Manganese accumulation in red blood cells as a biomarker of manganese exposure and neurotoxicity.
TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model.
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behaviors via BDNF But Not Norepinephrine.
An artificial protein modulator reprogramming neuronal protein functions.
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson's disease.
Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model.
Neurotransmitter accumulation and Parkinson's disease-like phenotype caused by anion channelrhodopsin opto-controlled astrocytic mitochondrial depolarization in substantia nigra pars compacta.
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
A noradrenergic pathway for the induction of pain by sleep loss.
Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
SIRT3-Mediated Deacetylation of SDHA Rescues Mitochondrial Bioenergetics Contributing to Neuroprotection in Rotenone-Induced PD Models.
Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease.
The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.
Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease.
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress.
Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit.
Effects of Renal Denervation on Gap Junction in High-Pacing-Induced Heart Failure Dogs.
The Impact of Highly Selective Thoracic Sympathectomy on the Progression of Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Impact of Liver Sympathetic Nervous System on Liver Fibrosis and Regeneration After Bile Duct Ligation in Rats.
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.
Involvement of the autonomic nervous system in colonic contractions in conscious Suncus murinus.
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.
Integrated network pharmacology and transcriptomics to explore the mechanism of compound Dihuang granule (CDG) protects dopaminergic neurons by regulating the Nrf2/HMOX1 pathway in the 6-OHDA/MPP(+)-induced model of Parkinson's disease.
Evaluation of the Neuroprotective Effect of Total Glycosides of Cistanche deserticola and Investigation of Novel Brain-Targeting Natural MAO-B Inhibitors.
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons-Vagus-Macrophage Axis in 70% Partial Hepatectomy of Mice.
Performance and Microstructure of Grouting Materials Made from Shield Muck.
A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease.
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model.
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model.
Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP-1 and modulating gut microbiota.
Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors.
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism.
Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse.
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.
Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.
Anti-inflammatory effects of myristic acid mediated by the NF-κB pathway in lipopolysaccharide-induced BV-2 microglial cells.
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson's disease.
Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease.
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice.
ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage.
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Imperatorin Improves Obesity-Induced Cardiac Sympathetic Nerve Injury Mediated by P2X4 Receptor in Stellate Sympathetic Ganglion.
CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson's Disease.
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.
Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism.
Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.
A zona incerta-basomedial amygdala circuit modulates aversive expectation in emotional stress-induced aversive learning deficits.
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.
Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.
Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing.
Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Guizhi-Fuling Treatment for Myocardial Ischemia.
Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling.
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.
Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.
Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Systematic Input-Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness.
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.
Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway.
Vagus Nerve Stimulation in Early Stage of Acute Myocardial Infarction Prevent Ventricular Arrhythmias and Cardiac Remodeling.
Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.
Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson's Disease.
Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala.
Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry.
Calcitriol Alleviates MPP(+)- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.
Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in Parkinson's disease models.
Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.
Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion.
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.
Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.
Primary Cilia in Amacrine Cells in Retinal Development.
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures.
Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity.
Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.
Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish.
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis.
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model.
Fenvalerate triggers Parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK/mTOR signaling pathway.
Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson's Disease.
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Differences in the number of oxytocin, vasopressin, and tyrosine hydroxylase cells in brain regions associated with mating among great, midday, and Mongolian gerbils.
Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.
Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP(+) and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway.
The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.
Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder.
Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia.
Microglia as modulators of exosomal alpha-synuclein transmission.
Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β(1-42) level.
Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1.
TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.
TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.
Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo.
Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.
Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.
Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.
Cui S, Wang S, Liu M, Zou Q, Cai Z, Ma J
Frontiers in cellular neuroscience 2026;20:1761155
Frontiers in cellular neuroscience 2026;20:1761155
Metabolomics Analysis Reveals Gut Microbiota-Associated Sakuranin Modulates Endometrial Stem Cell Differentiation and Inflammation to Alleviate Pain in Endometriosis.
Shi W, Wang M, Jin Z, Chen X, Li J, Lai H, Li X, Zhong Q, Chen Y, Chen S
Journal of pain research 2026;19:557430
Journal of pain research 2026;19:557430
Systems-level molecular and immunological evidence identifies Th17/Treg modulation as a key mechanism of CRSJ's neuroprotection in Parkinson's disease.
Li X, Li X, Chen S, Wang L, Xia J, Zheng M, Zhang C, Chen X, Cai J
Frontiers in aging neuroscience 2026;18:1764634
Frontiers in aging neuroscience 2026;18:1764634
Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH/NLRP3 Inflammasome pathway.
Liu X, Yang C, Wang X, Liao H, Liu H, Zhang L, Chen J, Zhao M, Ma J, Sun Y, Wang H
International immunopharmacology 2026 May 15;177:116526
International immunopharmacology 2026 May 15;177:116526
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsonism through a pathogenic loop with mitochondria.
Liu S, Ren Q, Mo G, Li Z, Huang H, Zhou Y, Miao Z, Cao X, Wu B, Xiao Z, Yu S, Wu G, Xia L, Cui J, Mo J, Li Y, Xia L, Shen J, Xiao S
The Journal of clinical investigation 2026 May 1;136(9)
The Journal of clinical investigation 2026 May 1;136(9)
Hypothalamic PVH Tyrosine Hydroxylase-Positive (Predominantly Dopaminergic) Neurons Mediate the Bidirectional Control of Neuropathic Pain and Comorbid Memory Impairments.
Shen K, Liu B, Yang L, Zhang S, Bu F, Yao M, Xu L
European journal of pain (London, England) 2026 Mar;30(3):e70233
European journal of pain (London, England) 2026 Mar;30(3):e70233
Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.
Wang G, Gong G, Yang X, Qian Y, Zhao Y, Li D, Liu M, Xu Z, Zhang F
Journal of advanced research 2026 Mar 9;
Journal of advanced research 2026 Mar 9;
Cardiac-specific sympathetic modulation, not splenic innervation, mediates PC6 electroacupuncture-induced cardioprotection via M2 macrophage polarization in mice with acute myocardial infarction.
Jiang MJ, Peng R, Lu XH, Yan YH, Qian DY, Zou LY, Liu XE, Chen LY, Bai H, Zhuang Y, Yu ML, Lu SF
Journal of integrative medicine 2026 Mar 3;
Journal of integrative medicine 2026 Mar 3;
Impact of NPAS2 on mPFC dopamine synthesis and nap behavior.
Guo L, Cen H, Huang Y, Li Z, Zeng K, Wu Z, Weng J, Guo X, He D, Liu X, Yang Z, Xu H, Hao T, Wei B, Diao X, Wu B
Nature communications 2026 Mar 16;17(1)
Nature communications 2026 Mar 16;17(1)
Evodiamine alleviates MPTP-induced Parkinson's disease in mice by regulating gut microbiota and suppressing TLR4/MyD88/NF-kB pathway.
Wang S, Zhu Y, Wang J, Jin W, Li N, Li Z, Chang Y, Jiang C, Wang T
Scientific reports 2026 Mar 13;16(1)
Scientific reports 2026 Mar 13;16(1)
Protein Modifications and Metabolic Alterations in the Rat Striatum Following Oil Mist Particulate Matter Exposure Revealed via Untargeted Metabolomics and Phosphoproteomics.
Nie H, Liu X, Shi Y, Liu H, Lai W, Li K, Tian L, Xi Z, Lin B
Toxics 2026 Mar 12;14(3)
Toxics 2026 Mar 12;14(3)
RELA as a Diagnostic Biomarker for Parkinson's Disease by Integrating Ferroptosis, Lipid Metabolism, and Neuroinflammation.
Chen Q, Jing Y, Bu W, Zhang J, Liu W, Shi C, Liu C, Su D
Inflammation 2026 Mar 11;49(1)
Inflammation 2026 Mar 11;49(1)
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
Yue M, Chen T, Chen W, Wei J, Liao B, Zhang J, Li F, Hong D, Fang X
Neural regeneration research 2026 Mar 1;21(3):1211-1221
Neural regeneration research 2026 Mar 1;21(3):1211-1221
Balenine alleviates neurodegeneration and inflammation in a mouse model of Parkinson's disease.
Chukai Y, Arisumi K, Yasunaga G, Sakai H, Tatara Y, Kasai S, Yamashita T, Ishiyama E, Kiyokawa K, Ozaki T
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130953
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130953
Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice.
An PP, Liang XY, Yao XY, Liao ZH, Tang YC, Cao N, Wang Z, Wang W, Niu HY, Tang CX, Chen J
Probiotics and antimicrobial proteins 2026 Jan;18(1):1187-1206
Probiotics and antimicrobial proteins 2026 Jan;18(1):1187-1206
Stress-Induced Activation of Prolactin-NR4A1-Midkine Axis Exacerbates Skin Inflammation.
Li Z, Quan H, Liu W, Chen J, Chu M, Tang X, Xue K, Liu X, Ma J, Bai Y, Dong R, Li B, Hao J, Guo W, Li Q, Dang E, Gudjonsson JE, Wang G, Shao S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09679
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09679
Low-dose ciprofol attenuates motor dysfunction in PD mice by inhibiting NLRP3 inflammasome activation.
Wang Y, Li M, Li Y, Guo J, Huo X, Gao J, Wang H
Behavioural brain research 2026 Jan 5;496:115826
Behavioural brain research 2026 Jan 5;496:115826
Activation of LH orexin neurons and VTA dopamine neurons is involved in anesthesia/surgery-induced sleep-wake disorders and delirium-like behaviors in mice.
Han S, He K, Cao L, Li S, Huang L
Scientific reports 2026 Jan 23;16(1):6035
Scientific reports 2026 Jan 23;16(1):6035
Multisensory integration in the mouse ventral visual thalamus mediates stress coping via locus coeruleus-related circuits.
Huang X, Liu X, Xu X, Hu Z, Wang S, Fu Y, Wang X, Song L, Yang Y, Lin S, So KF, Huang L, Tao Q, Ren C
Neuron 2026 Jan 21;114(2):307-324.e7
Neuron 2026 Jan 21;114(2):307-324.e7
Butyrate-Modified Hyaluronic Acid Ameliorates MPTP-Induced Parkinson's Disease via Modulating PINK1/Parkin-Involved Mitophagy and Intestinal Flora.
Sun Y, Cui L, Peng W, Chen R, Guan X, Liu J
Biomacromolecules 2026 Jan 12;27(1):134-149
Biomacromolecules 2026 Jan 12;27(1):134-149
Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood-brain barrier.
Wang Y, Chen R, Shi G, Huang X, Li K, Wang R, Cao X, Yang Z, Zhao N, Yan J
Neural regeneration research 2026 Jan 1;21(1):377-391
Neural regeneration research 2026 Jan 1;21(1):377-391
SIX2-Mediated Microglial M2 Polarization and Exosomal miR-3470b Delivery Protect Dopaminergic Neurons in Parkinson's Disease.
Kan JS, Cao XY, Ye YX, Huang XX, Sun GJ, Gao J
CNS neuroscience & therapeutics 2026 Feb;32(2):e70756
CNS neuroscience & therapeutics 2026 Feb;32(2):e70756
The Kv4.3 channel on c-low threshold mechanoreceptors in DRG is a key mediator transforming tactile stimuli into nociceptive signals in chemotherapy-induced neuropathy.
Zhang J, Wang X, Liu X, Li J, Qiao K, Sun J, Zuo J, Zhao W, He T, Li X, Guan Z, Zhang Y, Xu Y, Jia Q
Acta pharmaceutica Sinica. B 2026 Feb;16(2):854-878
Acta pharmaceutica Sinica. B 2026 Feb;16(2):854-878
Reducing Neuroinflammation via Inhibition of Fibrinogen Deposition and Microglial Activation as an Underlying Mechanism of Paning I Decoction in Ameliorating Parkinson's Disease Symptoms.
Chen YJ, Chen JW, Xie MR, Wang RZ, Wan YL, Zeng J, Zhong BW, Zhou SQ, Liu F
Immunity, inflammation and disease 2026 Feb;14(2):e70310
Immunity, inflammation and disease 2026 Feb;14(2):e70310
From Kitchen Spice to Neuroprotector: The Role of 6-Shogaol in Parkinson's Disease Management.
Jin J, Li X, Wang Y, Yan Z, Lv A, Zhang Y, Zhuang P, Guo H
Journal of agricultural and food chemistry 2026 Feb 4;74(4):3558-3573
Journal of agricultural and food chemistry 2026 Feb 4;74(4):3558-3573
FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.
Lu W, Jiang M, Zhuang J, Song J, Zhou C, Zhou Y, Zhu Z, Wu A, Sheng S, Zhu S, Wang Z
Journal of neuroinflammation 2026 Feb 23;23(1)
Journal of neuroinflammation 2026 Feb 23;23(1)
High-Resolution 3D reconstruction and visualization of normal adrenal vasculature and sympathetic nerves in mice.
Zhu S, Fu J, Liu Q, Du M, Ma L, Hu J, Peng C, Liu Y, Yin J, Xu Y, Huang W, Gao R, Li Q, Yang S, Xiong Y
Endocrine 2026 Feb 16;91(1):79
Endocrine 2026 Feb 16;91(1):79
Mitochondrial DNA drives NLRP3-IL-1β axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models.
Gan Q, Fu X, Zhou T, Fan N, Nan N, Wang Y, Yang Y, Gou S, Hu L, Zhou S
Cell death & disease 2026 Feb 10;17(1):213
Cell death & disease 2026 Feb 10;17(1):213
Chloride intracellular channel 4 contributes to Aβ-induced cognitive impairment in mice through the regulation of mitochondrial fission. CLIC4 promotes mitochondrial fission.
Wang J, Mao X, Zheng R, Gao H, Chen G, Zhang Y, Xu M, Lin Q, Nivar J, Tao YX, Sun M, Cao H, Zhang J, Li J
Cellular signalling 2026 Aug;144:112499
Cellular signalling 2026 Aug;144:112499
Therapeutic potential of Cistanche against Parkinson's disease via regulating circulating inflammation: Insights from Mendelian randomization, molecular docking, and in vivo studies.
Liu H, Chen Y, Li C, Zhang Q, Lin X, Lin Y, Xu Q
Experimental gerontology 2026 Apr;216:113071
Experimental gerontology 2026 Apr;216:113071
Sympathetic denervation alters pulmonary microbiota diversity and composition in mice.
Zhang J, Yang X, Xie L, Liu Q, Zhang X
International microbiology : the official journal of the Spanish Society for Microbiology 2026 Apr 20;
International microbiology : the official journal of the Spanish Society for Microbiology 2026 Apr 20;
Regulation of short-term declarative memory by selective activation of the locus coeruleus-retrosplenial cortex dopaminergic pathway and its pathological alterations in Parkinson's disease.
Yan Y, Gao L, Qiang X, Qiu Y, Shen Y, Mu C, Tang C
Progress in neuro-psychopharmacology & biological psychiatry 2026 Apr 2;146:111680
Progress in neuro-psychopharmacology & biological psychiatry 2026 Apr 2;146:111680
Transcranial magneto-acoustic stimulation improves corticostriatal transmission in direct medium spiny neurons and rescues neuroplasticity of Parkinson's disease model mice.
Xu Y, Zhang S, Mi J, Lu X, An Y, Liu J, Sun J, Wang Y, Xu G
NPJ Parkinson's disease 2026 Apr 1;
NPJ Parkinson's disease 2026 Apr 1;
Single-Cell Profiling Identifies Reward Behavior-Related Neurons and Alterations in the Ventral Tegmental Area Based on Arvcf-Knockout Mouse Model.
Zhang M, Zhang B, Wang Y, Chang Q, He J, Yang Z, Li MD
Research (Washington, D.C.) 2025;8:1030
Research (Washington, D.C.) 2025;8:1030
Investigation on Inhibiting SPHK - S1P Pathway to Improve ADHD Model Rats Behavior via Lipidomics.
Chai D, Sun Y, Lu J, Yao Y, Jiang C, Wu L, Cai Q
Neuropsychiatric disease and treatment 2025;21:2035-2052
Neuropsychiatric disease and treatment 2025;21:2035-2052
Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage.
Li X, Zhuang Y, Zhang YR, Fan KK, Chen XX, Chen XX, Liu XY, Sun J, Liu L
Frontiers in behavioral neuroscience 2025;19:1621017
Frontiers in behavioral neuroscience 2025;19:1621017
Electroacupuncture alleviates Parkinson's disease by inhibiting the NLRP3 inflammasome pathway.
Kang M, Cai J, Yi W, Zhang B, Ai L, Ning B, Dong J, Chen L, Fu W
American journal of translational research 2025;17(5):3619-3629
American journal of translational research 2025;17(5):3619-3629
Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway.
Huang L, Li Q, Wu J, He Y, Huang J, Xie S, Yang C, Ruan Q, Zhou Z, Deng M
Frontiers in aging neuroscience 2025;17:1568002
Frontiers in aging neuroscience 2025;17:1568002
Coixol ameliorates dopaminergic neurodegeneration by inhibiting neuroinflammation and protecting mitochondrial function.
Yang S, Han J, Xue M, Zhang Y, Yan A, Gao X, He J, Sun X, Fu S, Liu D, Huang B
Frontiers in pharmacology 2025;16:1657910
Frontiers in pharmacology 2025;16:1657910
(18)F-DOPA uptake illustration acts as an indicator for renal sympathetic activity.
Wu R, Shi S, Huang Y, Tian F, Hou J, Kong X, Sheng L, Zhang T, Tang L, Sun W
Frontiers in physiology 2025;16:1569699
Frontiers in physiology 2025;16:1569699
Mechanism of Tourette Syndrome Induced by ABGA-Mediated CaMKII-TH Pathway.
Wu X, Hao J, Jiang K, Wu M, Zhao X, Zhang X
The journal of gene medicine 2025 Sep;27(9):e70043
The journal of gene medicine 2025 Sep;27(9):e70043
Celastrol protected the MPTP-injected mice Parkinson's disease model via redox regulation of CDC37.
Liao W, Dong A, Hafeez F, Ye Q, Huang E
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157067
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157067
Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1α pathway.
Qi Y, Xie S, Chen J, Zhang C, Ma X, Yu Y, Yu X, Wang Y
The Journal of nutritional biochemistry 2025 Sep;143:109954
The Journal of nutritional biochemistry 2025 Sep;143:109954
Neurotoxicity of chronic nano-neodymium oxide exposure in zebrafish: Behavioral and molecular insights.
Zhang BF, Wu XZ, Wang JX, Liao YL, Cai ZX, Liu Y, Pei DS
Journal of hazardous materials 2025 Sep 5;495:138879
Journal of hazardous materials 2025 Sep 5;495:138879
Artemisinin alleviates Parkinson's disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats.
Yang XX, Wang GQ, Wen Q, Zhao YJ, Li DD, Zhang F
Genome biology 2025 Sep 4;26(1):267
Genome biology 2025 Sep 4;26(1):267
Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson's disease.
Han W, Wang T, Tan N, Liu H, He P, Hua Y, Fan Y
Journal of advanced research 2025 Sep 4;
Journal of advanced research 2025 Sep 4;
Biomimetic Nanoregulators Mediated Tyrosine Hydroxylase mRNA and Stimulator of Interferon Genes Antagonist Codelivery for Synergistic Therapy on Parkinson's Disease.
Yang L, Li S, Hou C, Zhang Y, Cheng L, Wang Z, He W, Zhang W
ACS nano 2025 Sep 30;19(38):33734-33748
ACS nano 2025 Sep 30;19(38):33734-33748
Ginsenoside Rk3 Alleviates Neuroinflammation and Gastrointestinal Dysfunction in Parkinson's Disease via Modulation of Gut Microbiota-Mediated Butyric Acid Metabolism.
Zhou S, Liu Y, Liu Y, Duan Z, Zhu C, Wang P, Fu R
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24139-24154
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24139-24154
Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson's Disease Model: Transcriptomic Evidence.
Lyu P, Wen F, Fu Z, Li J, Li Q, Cai X, Huang S, Qiu X, Zhang Z, Huang Y, Zhang J
Journal of integrative neuroscience 2025 Sep 18;24(9):40105
Journal of integrative neuroscience 2025 Sep 18;24(9):40105
Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways.
Zhang F, Xu J, Yuan Q, Xie Y, Zhang L, Zhang J, Xu Z, Liu M
Molecular neurobiology 2025 Oct;62(10):12394-12412
Molecular neurobiology 2025 Oct;62(10):12394-12412
LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson's Disease.
Liu X, Zheng Z, Xue C, Wang X, Li J, Liu Z, Xin W, Xu X, Zhou D, Yao L, Lu G
Inflammation 2025 Oct;48(5):3666-3691
Inflammation 2025 Oct;48(5):3666-3691
SIRT1 Expression in Human Gastrointestinal Tumors and Its Clinical Significance.
Liu W, Li X, Deng W
Cancer medicine 2025 Oct;14(19):e71217
Cancer medicine 2025 Oct;14(19):e71217
Overexpression of Rap1B alleviate central precocious puberty and neurodevelopmental damage.
Liu X, Zeng L
Cellular signalling 2025 Oct;134:111941
Cellular signalling 2025 Oct;134:111941
Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis-Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis.
He R, Wu B, Han L, Li M, Guo W, Fu J, Mei B, Gross ER, Liu X, Lu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e04406
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e04406
PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson's disease.
Yin S, Zhai Y, Song R, Wu J, Zhang Y, Yu M, Ma H, Shen M, Lai X, Jin W, Xu Y, Yan J
Cell death & disease 2025 Oct 6;16(1):700
Cell death & disease 2025 Oct 6;16(1):700
P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP(+)/MPTP-induced Parkinson's disease.
Si Y, Yan S, Li X, Ding W, Zhang X, Jia K, Yao L, Yang F, Shi W
Brain research 2025 Oct 15;1865:149824
Brain research 2025 Oct 15;1865:149824
The Identification and Synthesis of New Sea Cucumber Peptides Leveraging Peptidomics Technology, along with their Anti-Parkinson's Disease Efficacy.
Liu J, Shi Y, Jin L, Sun B, Wang R, Ge G, Zhu G, Cui X, Zhao J, Zhang Y, Li S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Oct 13;20(1):91
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Oct 13;20(1):91
Sodium Para-Aminosalicylic Acid Inhibits Manganese-Iron Co-exposure-induced Inflammation via the NF-κB Pathway in Rat Substantia Nigra.
Li ZC, Wei YF, Zhou TT, Ho TT, Luo JJ, Li XF, Aschner M, Peng DJ, Jiang YM
Neurochemical research 2025 Oct 11;50(5):323
Neurochemical research 2025 Oct 11;50(5):323
Tyrosine hydroxylase-expressing neurons in the paraventricular nucleus of the hypothalamus regulate peripheral leukocytes during inflammatory pain.
Li X, Jia Y, Li Y, Peng M, Xiong M, Zhu Q, Gao Y, Ke C
International immunopharmacology 2025 Oct 10;163:115241
International immunopharmacology 2025 Oct 10;163:115241
Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning.
Cui C, Luo G, Lei J, Shi Y, Yao Y, Ren K, Yang J, Li T, Li M, Peng X, Yang X, Du J, Chen S, Tian B, Zhang P
Translational psychiatry 2025 Oct 10;15(1):395
Translational psychiatry 2025 Oct 10;15(1):395
Pyridoxal phosphate inhibits alpha-synuclein-induced ferroptosis by activating GOT1 to enhance the methionine salvage pathway in Parkinson's disease.
Min X, Du Z, Wei J, Yuan Z, She Y, Jin X, Su Z, Mao H, Cai J, Zhu Z, He X
Experimental neurology 2025 Nov;393:115411
Experimental neurology 2025 Nov;393:115411
Carvedilol Confers Neuroprotective Activity Through Modulating Ferroptosis Key Players and PINK1/PARKIN Mediated Mitophagy in an Experimental Parkinson's Rat Model.
Abuelezz NZ, Ahmed MK, Abd El Aziz AE, El Sayed NS
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70607
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70607
Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson's Disease.
Cui C, Yao Y, Shi Y, Lei J, Ren K, Wan K, Li T, Luo G, Xu Q, Li M, Peng X, Yang X, Yang J, Du J, Chen S, Tian B, Zhang P
PLoS biology 2025 Nov;23(11):e3003435
PLoS biology 2025 Nov;23(11):e3003435
The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice.
Song D, Zou X, Ma D, Zhao Y, Liu T, Shen B, Cheng O
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e17664
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e17664
Short-Chain Fatty Acids Enhance EAAT2-Mediated Glutamate Clearance and Alleviate Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease.
Li W, Li J, Liu L, Hu W, Wu L, Ding S, Yu B, Jiang L, Liu H
Antioxidants (Basel, Switzerland) 2025 Nov 27;14(12)
Antioxidants (Basel, Switzerland) 2025 Nov 27;14(12)
Noradrenergic α(2) Receptor Modulates Cav2.2-Mediated Nociception in Parkinson's Disease Through Spinal Neuro-glial Network.
Cui S, He Y, Gu Y, Wu H, Guo D, Zhang L
Molecular neurobiology 2025 Nov 19;63(1):86
Molecular neurobiology 2025 Nov 19;63(1):86
GLP-1/GIP dual agonist tirzepatide alleviates mice model of Parkinson's disease by promoting mitochondrial homeostasis.
Tian R, Liu K, Lai H, Liao C, Li J, Tu H
International immunopharmacology 2025 Nov 14;165:115443
International immunopharmacology 2025 Nov 14;165:115443
Activin A protects against lipopolysaccharide/TNF-α induced damage of dopaminergic neurons both in vivo and in vitro by regulating mitochondrial fusion.
Zhang Y, Tian S, Niu M, Yang H, Liu L, Kang Y, Yin Y
Neuroscience 2025 Nov 10;587:108-122
Neuroscience 2025 Nov 10;587:108-122
Pharmacological and electrophysiological characterization of the novel Kv7 channel inhibitor racecadotril in Parkinson's disease.
Yang B, Liu H, Zhang S, Liu B, Sun Q, Li W, Zheng R, Cui Q, Gu Y, Li X, Zhang J, Liu Y, Zhang F
Neuropharmacology 2025 Nov 1;278:110565
Neuropharmacology 2025 Nov 1;278:110565
Remote ischemic conditioning as a potential therapy for Parkinson's Disease: Inhibiting TLR4-Driven neuroinflammation and oxidative damage.
Cai L, Ding Y, Tekreeti AA, Li F, Zhu Y, Geng X, Ji X
Brain research 2025 Nov 1;1866:149920
Brain research 2025 Nov 1;1866:149920
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.
Guo Q, Li ZF, Hu DY, Li PJ, Wu KN, Fan HH, Deng J, Wu HM, Zhang X, Zhu JH
The EMBO journal 2025 May;44(10):2906-2927
The EMBO journal 2025 May;44(10):2906-2927
Aromatherapy With Nardostachys Jatamansi DC. Essential Oil Targeting the MAOA Gene Regulates Cardiac Neural Remodeling and Amino Acid Metabolism to Alleviate Sleep Deprivation-Induced Myocardial Injury.
Yang H, Li Y, Feng L, Jiang Z, Han Y, Xiao Y, Wu X, Zeng K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70635
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70635
Inhalation of Acori Tatarinowii Rhizoma essential oil alleviates dyskinesia in Parkinson's disease rats through the regulation of neuroinflammation.
Hu Y, Zhao Y, Mao Z, Yang J, Huang B, Miao J, Miao M
Journal of ethnopharmacology 2025 May 28;348:119705
Journal of ethnopharmacology 2025 May 28;348:119705
Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson's disease.
Zou W, Kou L, Wang Y, Jin Z, Xiong N, Wang T, Xia Y
NPJ Parkinson's disease 2025 May 28;11(1):141
NPJ Parkinson's disease 2025 May 28;11(1):141
Endosomal protein DENND10 promotes developmental competence of neurite extension.
Li A, Zhang J, Ma C, Qi L, Hu Q, Li Q, Fang Y, Song J, Liu Y, Zhang Y
iScience 2025 May 16;28(5):112385
iScience 2025 May 16;28(5):112385
Revealing the therapeutic targets, mechanisms, and heterogeneity of Huatan Jieyu Granules for Parkinson's disease through single-cell sequencing.
Zhu S, Liu M, Han S, Zhu J, Deng X, Tian Y, Yang D
Journal of pharmaceutical and biomedical analysis 2025 May 15;257:116679
Journal of pharmaceutical and biomedical analysis 2025 May 15;257:116679
Nerve infiltration of bladder cancer predicts response to immunotherapy.
Lu X, Shui KM, Ji H, Chen JY, Yan C, Li P, Xu T
Biochemical and biophysical research communications 2025 May 1;761:151687
Biochemical and biophysical research communications 2025 May 1;761:151687
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice.
Zuo X, Bai HJ, Zhao QL, Zhang SH, Zhao X, Feng XZ
Molecular neurobiology 2025 Mar;62(3):3053-3066
Molecular neurobiology 2025 Mar;62(3):3053-3066
Identification and validation of Atp5f1c in CD4(+) T cell as a hub protein in Parkinson's disease.
Wang G, Wang Y, Tang X, Li D, Zhao Y, Zhang F
International journal of biological macromolecules 2025 Mar;297:139858
International journal of biological macromolecules 2025 Mar;297:139858
Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy.
Liu H, Yu R, Zhang M, Zheng X, Zhong L, Yang W, Luo Y, Huang Z, Zheng J, Zhong H, Wei X, Zheng W, Yu Y, Wang Q
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Mar;22(2):e00538
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Mar;22(2):e00538
Effects of moderate static magnetic fields on voltage-gated potassium ion channels in sympathetic neuron-like PC12 cells.
Kaneda E, Kawai T, Okamura Y, Miyagawa S
Physiological reports 2025 Mar;13(6):e70236
Physiological reports 2025 Mar;13(6):e70236
The ARC(CRABP1) neurons play a crucial role in the regulation of energy homeostasis.
Yan L, Zhang X, Jin L, Li Y, Chen Y, Zhang J, Sun Z, Qi J, Qu C, Dong G, Zhang Y, Jiang Q, Liu A, Li J
Nature communications 2025 Mar 8;16(1):2319
Nature communications 2025 Mar 8;16(1):2319
SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota.
Chen M, Zhang Y, Hou L, Zhao Z, Tang P, Sun Q, Zhao J, Wang Q
NPJ Parkinson's disease 2025 Mar 6;11(1):43
NPJ Parkinson's disease 2025 Mar 6;11(1):43
Transcranial magneto-acoustic stimulation enhances motor function and modulates cortical excitability of motor cortex in a Parkinson's disease mouse model.
Zhang S, Wang Q, Xu Y, Zhang H, Mi J, Lu X, Fan R, Lv J, Xu G
Behavioural brain research 2025 Mar 5;480:115364
Behavioural brain research 2025 Mar 5;480:115364
Cholesterol promotes hair growth through activating sympathetic nerves and enhancing the proliferation of hair follicle stem cells.
Guo M, Jiang J, Zhang A, Yu W, Huang X
Molecular medicine (Cambridge, Mass.) 2025 Mar 5;31(1):86
Molecular medicine (Cambridge, Mass.) 2025 Mar 5;31(1):86
Corilagin Attenuates Neuronal Apoptosis and Ferroptosis of Parkinson's Disease through Regulating the TLR4/Src/NOX2 Signaling Pathway.
Lei Y, Zhou J, Xu D, Chai S, Xiong N
ACS chemical neuroscience 2025 Mar 5;16(5):968-980
ACS chemical neuroscience 2025 Mar 5;16(5):968-980
Investigating the effect of Arvcf reveals an essential role on regulating the mesolimbic dopamine signaling-mediated nicotine reward.
Wang Y, Yang Z, Shi X, Han H, Li AN, Zhang B, Yuan W, Sun YH, Li XM, Lian H, Li MD
Communications biology 2025 Mar 13;8(1):429
Communications biology 2025 Mar 13;8(1):429
Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model.
Feng S, Gui J, Qin B, Ye J, Zhao Q, Guo A, Sang M, Sun X
Molecular neurobiology 2025 Jun;62(6):6636-6654
Molecular neurobiology 2025 Jun;62(6):6636-6654
Ceftriaxone affects ferroptosis and alleviates glial cell activation in Parkinson's disease.
Zhi H, Wang X, Chen Y, Cai Z, Li J, Guo D
International journal of molecular medicine 2025 Jun;55(6)
International journal of molecular medicine 2025 Jun;55(6)
DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson's disease vulnerability.
Yao Y, Cui C, Shi Y, Lei J, Li T, Li M, Peng X, Yang X, Ren K, Yang J, Luo G, Du J, Chen S, Zhang P, Tian B
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 Jun;50(7):1051-1062
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 Jun;50(7):1051-1062
Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.
Chen Z, Zhou Y, Xue C, Zeng L, Deng S, Xu Z, Li M, Zhao H, He X, Liu S, Liu J, Liu S, Zhao S, Zhang S, Peng X, Wu X, Bai R, Zhuang L, Wu S, Zhang J, Lin D, Huang X, Zheng J
Nature cell biology 2025 Jun;27(6):1035-1047
Nature cell biology 2025 Jun;27(6):1035-1047
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells.
Lai M, Zhou W, Zou W, Qiu L, Liang Z, Chen W, Wang Y, Guo B, Zhao C, Zhang S, Lai P, Hu L, Liu X, Jiang Y, Chen Y, Huang MJ, Bai X, Zou Z
Nature communications 2025 Jun 4;16(1):5206
Nature communications 2025 Jun 4;16(1):5206
Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway.
Xu D, ShenTu C, Zong C, Fu W, Ling J, Shao P, Liu X, Chen Y, Xu T
Journal of ethnopharmacology 2025 Jun 26;350:120079
Journal of ethnopharmacology 2025 Jun 26;350:120079
Erzhi pill promotes norepinephrine synthesis in locus coeruleus through ERβ-TFAP2A-TH plays a neuroprotective role.
Xue A, Zhao D, Xu H, Lei X, Li D, Ren Y, Zhou Q, Qiu Q, Cai L, Zhang Y, Zhang N
Journal of ethnopharmacology 2025 Jun 26;350:120015
Journal of ethnopharmacology 2025 Jun 26;350:120015
Saponins from Panax japonicus Enhance Lipolysis via Acting on FGF21-β-Klotho/FGFR1 in Obese Mice.
Wang T, Huang Y, Hu M, Huang X, Yu D, Jia L, Zhi W, Mu Y, Zhou Z, Wang J
Journal of agricultural and food chemistry 2025 Jun 25;73(25):15624-15636
Journal of agricultural and food chemistry 2025 Jun 25;73(25):15624-15636
Theta oscillation synchronize VTA and mPFC during ethanol-induced conditioned place preference and stress-evoked anxiety.
Shi Y, Lei J, Cui C, Yao Y, Ren K, Luo G, Yang X, Peng X, Li M, Yang J, Li T, Chen S, Du J, Tian B, Zhang P
Translational psychiatry 2025 Jun 19;15(1):206
Translational psychiatry 2025 Jun 19;15(1):206
Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
Fu G, Li T, Zhao Y, Zhang S, Xue X, Yang Y, Li T, Luo S, Yue G, Lei T
Chinese medicine 2025 Jun 16;20(1):87
Chinese medicine 2025 Jun 16;20(1):87
Lamellar Schwann cells in the Pacinian corpuscle potentiate vibration perception.
Chen YT, de Thomas Wagner D, Loutit AJ, Nourizonoz A, Ulanova M, Graikou D, Chang MS, Croisier-Coeytaux MC, Clerc-Rosset S, Blanc J, Knott G, Lee KS, Huber D
Science advances 2025 Jun 13;11(24):eadt5110
Science advances 2025 Jun 13;11(24):eadt5110
Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson's disease through integrative multi-omics analysis.
Zhang H, Fan C, Li L, Liu F, Li S, Ma L, Yang Y, Cooper DN, Yang Y, Hu R, Zhao H
NPJ Parkinson's disease 2025 Jun 13;11(1):167
NPJ Parkinson's disease 2025 Jun 13;11(1):167
Narirutin reduces microglia-mediated neuroinflammation by inhibiting the JAK2/STAT3 pathway in MPP(+)/MPTP-induced Parkinson's disease models.
Gao Y, Liu W, Shi L, Yang P, Yang L, Zhao M, Luo L
Experimental neurology 2025 Jul;389:115232
Experimental neurology 2025 Jul;389:115232
Hyperglycemia Aggravates 6-Hydroxydopamine-Induced Neuronal Ferroptosis via SLC7A11-Dependent Pathway in Diabetic PD Rat Model.
Zhao Y, Wang D, Wang Y, Mu D, Qu L, Li R
CNS neuroscience & therapeutics 2025 Jul;31(7):e70487
CNS neuroscience & therapeutics 2025 Jul;31(7):e70487
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
Song N, Wang X, Ha L, Hu L, Mei S, Liang Y, Zhao Y, Yang X, Zhang Q, Zhou Y, Ding J, Liu Y, Zhou Q, Han F, Hu G, Lu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2503579
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2503579
Dopamine Alleviated Diabetic Retinal Neurodegeneration through Protecting Retinal Ganglion Cells from Ferroptosis via the Nrf2/HO‑1 Signaling Pathway.
Rao S, Xiao K, Chen X, Sun X
ACS omega 2025 Jul 22;10(28):30397-30410
ACS omega 2025 Jul 22;10(28):30397-30410
Comparison of Two MPTP Doses on Mouse Behaviors and Pathologies.
Qi Y, Zhang Z, Xue J, Yao S, Lu X, Tang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70822
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70822
Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye.
Wang D, Ma Y, Zhang M, Li F, Gao N, Qi Y, Shang Z, Yang R
Translational vision science & technology 2025 Jul 1;14(7):4
Translational vision science & technology 2025 Jul 1;14(7):4
Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway.
Qi Y, Dong Y, Chen J, Xie S, Ma X, Yu X, Yu Y, Wang Y
Experimental neurology 2025 Jan;383:115001
Experimental neurology 2025 Jan;383:115001
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.
Liu Y, Qin K, Dou K, Ren J, Hou B, Xie A
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553
Astrocyte-neuron communication through the complement C3-C3aR pathway in Parkinson's disease.
Chi X, Yin S, Sun Y, Kou L, Zou W, Wang Y, Jin Z, Wang T, Xia Y
Brain, behavior, and immunity 2025 Jan;123:229-243
Brain, behavior, and immunity 2025 Jan;123:229-243
Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.
Cai Z, Liang C, Huang K, Luo J, Lu R, Lai Y, Zheng D, Lin Z, Zhong J, Dai J, Huang J, Zhang H, Chen J
International immunopharmacology 2025 Jan 27;146:113928
International immunopharmacology 2025 Jan 27;146:113928
Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection.
Cao P, Liu Y, Ni Z, Zhang M, Wei HR, Liu A, Guo JR, Yang Y, Xu Z, Guo Y, Zhang Z, Tao W, Wang L
Science advances 2025 Jan 24;11(4):eadq3874
Science advances 2025 Jan 24;11(4):eadq3874
OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
Song X, Liu T, Yu L, Ji Q, Guo X, Zong R, Li Y, Huang G, Xue Q, Fu Q, Liu B, Zheng Y, Chen L, Gao C, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700
Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling.
Zhang J, Fu Z, Wen F, Lyu P, Huang S, Cai X, Zhang Z, Zhang Y, Fan C, Man W, Sun X, Huang Y
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Journal of neurophysiology 2025 Feb 1;133(2):490-501
Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease.
Geng Y, Wang RY, Dong MY, Qian YL, Wang XH, Xia WW, Shen Y, Zhang KZ
Inflammation 2025 Dec;48(6):3986-4005
Inflammation 2025 Dec;48(6):3986-4005
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Li Z, Sun X, Wang Y, Zhang F, Wang L, Ai C, Zhang X, Yin X, Liu C, Li C, Lu C
Basic research in cardiology 2025 Dec;120(6):1225-1247
Basic research in cardiology 2025 Dec;120(6):1225-1247
CAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness.
Zhang Z, Wang C, Sun Z, Shi X, Shuai Y, Wang Y, Wang Y, Guo H, Liu R, Luo J
Nature communications 2025 Dec 2;17(1):203
Nature communications 2025 Dec 2;17(1):203
VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice.
Li M, Ren K, Cui C, Shi Y, Lei J, Li T, Yang J, Peng X, Yang X, Yao Y, Luo G, Du J, Chen S, Zhang P, Tian B
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 Aug;50(9):1364-1375
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025 Aug;50(9):1364-1375
PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology.
Zhang C, Huang Z, Huang X, Ma Y, Cao Y, Zhang Z, Wang R, Ren H, Zheng L, Liu CF, Wang G
Autophagy 2025 Aug;21(8):1623-1643
Autophagy 2025 Aug;21(8):1623-1643
Garlic-Derived Allicin Attenuates Parkinson's Disease via PKA/p-CREB/BDNF/DAT Pathway Activation and Apoptotic Inhibition.
Zeng W, Wang Y, Liu Y, Liu X, Qi Z
Molecules (Basel, Switzerland) 2025 Aug 4;30(15)
Molecules (Basel, Switzerland) 2025 Aug 4;30(15)
Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease.
Zhang S, Wan G, Qiu Y, Zhang M, Deng H, Wang Q, Hu J, Gui J, Chen D, Huang B, Ran J
NPJ Parkinson's disease 2025 Aug 11;11(1):237
NPJ Parkinson's disease 2025 Aug 11;11(1):237
Behavioral, biochemical, and molecular characterization of MPTP/p-intoxicated mice.
Tang X, Xue J, Chen R, Xing J, Lu X, Cui L
Experimental neurology 2025 Apr;386:115168
Experimental neurology 2025 Apr;386:115168
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Han X, He G, Wang J, Lou H, Chen L, Zhang L, Liu B, Wu D, Liu X, Wang S, Zhang C, Guo L
Metabolic brain disease 2025 Apr 4;40(4):170
Metabolic brain disease 2025 Apr 4;40(4):170
Akkermansia muciniphila protects against dopamine neurotoxicity by modulating butyrate to inhibit microglia-mediated neuroinflammation.
Xu K, Wang G, Gong J, Yang X, Cheng Y, Li D, Sheng S, Zhang F
International immunopharmacology 2025 Apr 16;152:114374
International immunopharmacology 2025 Apr 16;152:114374
Electroacupuncture Improves Cardiac Function via Inhibiting Sympathetic Remodeling Mediated by Promoting Macrophage M2 Polarization in Myocardial Infarction Mice.
Peng R, Shi J, Jiang M, Qian D, Yan Y, Bai H, Yu M, Cao X, Fu S, Lu S
Mediators of inflammation 2024;2024:8237681
Mediators of inflammation 2024;2024:8237681
Targeted Liposomal Co-Delivery Dopamine with 3-n-Butylphthalide for Effective Against Parkinson's Disease in Mice Model.
Liang Y, Feng L, Zheng Y, Gao Y, Shi R, Zhang Z, Ying X, Zeng Y
International journal of nanomedicine 2024;19:12851-12870
International journal of nanomedicine 2024;19:12851-12870
Rhein alleviates MPTP-induced Parkinson's disease by suppressing neuroinflammation via MAPK/IκB pathway.
Qin X, Wang S, Huang J, Hu B, Yang X, Liang L, Zhou R, Huang W
Frontiers in neuroscience 2024;18:1396345
Frontiers in neuroscience 2024;18:1396345
Cardiac sympathetic overdrive, M2 macrophage activation and fibroblast heterogeneity are associated with cardiac remodeling in a chronic pressure overload rat model of HFpEF.
Sun F, Yuan L, Wang Z, Cui X, Lv N, Zhang T, Zhang Y, Cai J
Frontiers in pharmacology 2024;15:1364758
Frontiers in pharmacology 2024;15:1364758
Electroacupuncture Alleviates Obesity and Insulin Resistance via the GLP-1-VTADA Reward Circuit.
Zhu Y, Tian J, Wei X, Jia S, Shu Q
Neuroendocrinology 2024;114(3):263-278
Neuroendocrinology 2024;114(3):263-278
NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Wang H, Mao W, Zhang Y, Feng W, Bai B, Ji B, Chen J, Cheng B, Yan F
Free radical biology & medicine 2024 Sep;222:331-343
Free radical biology & medicine 2024 Sep;222:331-343
Catecholamines-based myocardial injury after acute ischemic stroke and effects of Naoxintong capsule therapy.
Ouyang Y, Hu S, Chang M, Xu J, Tian G, Kong X, Liu J, Zhang D, Zhang F, Yang H, Tang L, Wu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155697
Therapeutic potential of Canna edulis RS3-resistant starch in alleviating neuroinflammation and apoptosis in a Parkinson's disease rat model.
He QK, Wang XY, Hu W, Cai J, Chen P, Liu MW, Wu YH
Heliyon 2024 Sep 30;10(18):e38072
Heliyon 2024 Sep 30;10(18):e38072
Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells.
Li M, Yang XK, Yang J, Li TX, Cui C, Peng X, Lei J, Ren K, Ming J, Zhang P, Tian B
Neuron 2024 Sep 25;112(18):3192-3210.e6
Neuron 2024 Sep 25;112(18):3192-3210.e6
Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.
Ye J, Sun X, Jiang Q, Gui J, Feng S, Qin B, Xie L, Guo A, Dong J, Sang M
Journal of nanobiotechnology 2024 Sep 14;22(1):567
Journal of nanobiotechnology 2024 Sep 14;22(1):567
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao X, Fu S, Wen J, Yan A, Yang S, Zhang Y, Liu D, He D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson's disease: association with peripheral inflammatory regulatory T-cells and SYT6.
Xie F, Shen B, Luo Y, Zhou H, Xie Z, Zhu S, Wei X, Chang Z, Zhu Z, Ding C, Jin K, Yang C, Batzu L, Chaudhuri KR, Chan LL, Tan EK, Wang Q
Molecular neurodegeneration 2024 Oct 25;19(1):80
Molecular neurodegeneration 2024 Oct 25;19(1):80
Dorsal raphe dopaminergic neurons target CaMKII(+) neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors.
Wang W, Wang D, Zhao D, Xu L, Jiang S, Zhang Y, Cui M, Liu J, Meng F, Liu C, Liu D, Li W, Li C
Translational psychiatry 2024 Oct 2;14(1):408
Translational psychiatry 2024 Oct 2;14(1):408
S-(N,N-diethyldithiocarbamoyl)-N-acetyl-l-cysteine for the treatment of non-small cell lung cancer through regulating NF-κB signalling pathway without neurotoxicity.
Lv H, Yang H, Duan Y, Yan C, Li G, Zhao G, Sun F, Feng Y, Li Y, Fu Y, Li Y, Zhao Z, Jia X
Journal of drug targeting 2024 Nov;32(9):1111-1124
Journal of drug targeting 2024 Nov;32(9):1111-1124
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao C, Liu H
Cell death and differentiation 2024 Nov;31(11):1410-1421
Cell death and differentiation 2024 Nov;31(11):1410-1421
Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa-induced dyskinesia in a mouse model of Parkinson's disease.
Kambey PA, Wu J, Liu W, Su M, Buberwa W, Tang C
Gene therapy 2024 Nov;31(11-12):614-624
Gene therapy 2024 Nov;31(11-12):614-624
Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson's and Alzheimer's disease co-pathology and behavior impairments.
Xiang J, Tang J, Kang F, Ye J, Cui Y, Zhang Z, Wang J, Wu S, Ye K
Neuron 2024 Nov 6;112(21):3585-3601.e5
Neuron 2024 Nov 6;112(21):3585-3601.e5
Identifying genetic targets in clinical subtypes of Parkinson's disease for optimizing pharmacological treatment strategies.
Kong D, Li C, Ma L, Du L, Jiang N, Zhao X, Zhang S, Zhao Z, Fang L, Du G
Signal transduction and targeted therapy 2024 Nov 18;9(1):320
Signal transduction and targeted therapy 2024 Nov 18;9(1):320
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Wang CC, Hu XM, Long YF, Huang HR, He Y, Xu ZR, Qi ZQ
Life sciences 2024 Nov 1;356:123014
Life sciences 2024 Nov 1;356:123014
Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways.
Wang P, Chen C, Shan M
Journal of biochemical and molecular toxicology 2024 May;38(5):e23714
Journal of biochemical and molecular toxicology 2024 May;38(5):e23714
LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
Zheng Z, Zhang S, Liu X, Wang X, Xue C, Wu X, Zhang X, Xu X, Liu Z, Yao L, Lu G
Journal of cellular physiology 2024 May;239(5):e31250
Journal of cellular physiology 2024 May;239(5):e31250
Manganese accumulation in red blood cells as a biomarker of manganese exposure and neurotoxicity.
Deng X, Guo Y, Jin X, Si H, Dai K, Deng M, He J, Hao C, Yao W
Neurotoxicology 2024 May;102:1-11
Neurotoxicology 2024 May;102:1-11
TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model.
Niu B, Zhao M, Gao X, Xu J, Yu L
Experimental neurology 2024 Mar;373:114642
Experimental neurology 2024 Mar;373:114642
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behaviors via BDNF But Not Norepinephrine.
Zhang Q, Xue Y, Wei K, Wang H, Ma Y, Wei Y, Fan Y, Gao L, Yao H, Wu F, Ding X, Zhang Q, Ding J, Fan Y, Lu M, Hu G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2303503
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2303503
An artificial protein modulator reprogramming neuronal protein functions.
Lin P, Zhang B, Yang H, Yang S, Xue P, Chen Y, Yu S, Zhang J, Zhang Y, Chen L, Fan C, Li F, Ling D
Nature communications 2024 Mar 6;15(1):2039
Nature communications 2024 Mar 6;15(1):2039
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson's disease.
Yu D, Wang H, Zhai Y, Lei Z, Sun M, Chen S, Yin P, Wang X
Biological research 2024 Mar 16;57(1):9
Biological research 2024 Mar 16;57(1):9
Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model.
Zhang Z, Wang R, Zhou H, Wu D, Cao Y, Zhang C, Sun H, Mu C, Hao Z, Ren H, Wang N, Yu S, Zhang J, Tao M, Wang C, Liu Y, Liu L, Liu Y, Zang J, Wang G
Cellular and molecular life sciences : CMLS 2024 Mar 12;81(1):128
Cellular and molecular life sciences : CMLS 2024 Mar 12;81(1):128
Neurotransmitter accumulation and Parkinson's disease-like phenotype caused by anion channelrhodopsin opto-controlled astrocytic mitochondrial depolarization in substantia nigra pars compacta.
Li SM, Wang DD, Liu DH, Meng XY, Wang Z, Guo X, Liu Q, Liu PP, Li SA, Wang S, Yang RZ, Xu Y, Wang L, Kang JS
MedComm 2024 Jun;5(6):e568
MedComm 2024 Jun;5(6):e568
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Yang R, Li DD, Li XX, Yang XX, Gao HM, Zhang F
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
A noradrenergic pathway for the induction of pain by sleep loss.
Lou Q, Wei HR, Chen D, Zhang Y, Dong WY, Qun S, Wang D, Luo Y, Zhang Z, Jin Y
Current biology : CB 2024 Jun 17;34(12):2644-2656.e7
Current biology : CB 2024 Jun 17;34(12):2644-2656.e7
Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
Cao XY, Liu Y, Kan JS, Huang XX, Kambey PA, Zhang CT, Gao J
Brain research bulletin 2024 Jun 15;212:110970
Brain research bulletin 2024 Jun 15;212:110970
X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
Mou J, Ning XL, Wang XY, Hou SY, Meng FB, Zhou C, Wu JW, Li C, Jia T, Wu X, Wu Y, Chen Y, Li GB
Journal of medicinal chemistry 2024 Jun 13;67(11):8730-8756
Journal of medicinal chemistry 2024 Jun 13;67(11):8730-8756
SIRT3-Mediated Deacetylation of SDHA Rescues Mitochondrial Bioenergetics Contributing to Neuroprotection in Rotenone-Induced PD Models.
Shen Y, Wang X, Nan N, Fu X, Zeng R, Yang Y, Xian S, Shi J, Wu Q, Zhou S
Molecular neurobiology 2024 Jul;61(7):4402-4420
Molecular neurobiology 2024 Jul;61(7):4402-4420
Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease.
Zhao H, Song J, Wang T, Fan X
Nanomedicine : nanotechnology, biology, and medicine 2024 Jul;59:102755
Nanomedicine : nanotechnology, biology, and medicine 2024 Jul;59:102755
The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.
Lyu Z, Xiao G, Xie D, Huang D, Chen Y, Wu C, Lai Y, Song Z, Huang L, Ming H, Jiang Y, Wang J, Chen R, Luo W
Brain and behavior 2024 Jul;14(7):e3605
Brain and behavior 2024 Jul;14(7):e3605
Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease.
Ma L, Mi N, Wang Z, Bao R, Fang J, Ren Y, Xu X, Zhang H, Tang Y
Journal of chemical neuroanatomy 2024 Jul;138:102424
Journal of chemical neuroanatomy 2024 Jul;138:102424
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress.
Lu J, Zhang X, Su K, Luo H, Liu C, Yang Y, He B, Wang C, Zhao Z, Liu X, Wang X, Meng P, Lv D, Wang C, Kelley KW, Wang L, Cui B, Liu Q, Peng F
Cell communication and signaling : CCS 2024 Jul 25;22(1):375
Cell communication and signaling : CCS 2024 Jul 25;22(1):375
Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit.
Lei J, Zhang P, Li T, Cui C, Li M, Yang X, Peng X, Ren K, Yang J, Shi Y, Luo G, Yao Y, Tian B
Cell reports 2024 Jul 23;43(7):114383
Cell reports 2024 Jul 23;43(7):114383
Effects of Renal Denervation on Gap Junction in High-Pacing-Induced Heart Failure Dogs.
Liang X, Shang S, Bai Z, Wang Q, Fan Y, Xiaokereti J, Lv H, Zhou X, Lu Y, Tang B
Anatolian journal of cardiology 2024 Jul 16;28(9):429-436
Anatolian journal of cardiology 2024 Jul 16;28(9):429-436
The Impact of Highly Selective Thoracic Sympathectomy on the Progression of Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
Liu W, Men C, Liu Z, Li Q, Liu K, Liu H, Zhang L, Zheng X
Journal of physiological investigation 2024 Jul 1;67(4):207-214
Journal of physiological investigation 2024 Jul 1;67(4):207-214
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Liu Y, Duan R, Li P, Zhang B, Liu Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
Impact of Liver Sympathetic Nervous System on Liver Fibrosis and Regeneration After Bile Duct Ligation in Rats.
Xue J, Jiang T, Humaerhan J, Wang M, Ning J, Zhao H, Aji T, Shao Y
Journal of molecular neuroscience : MN 2024 Jan 6;74(1):4
Journal of molecular neuroscience : MN 2024 Jan 6;74(1):4
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.
Huang W, Wang Y, Huang W
Neuroscience letters 2024 Jan 31;821:137608
Neuroscience letters 2024 Jan 31;821:137608
Involvement of the autonomic nervous system in colonic contractions in conscious Suncus murinus.
Suzuki M, Watanabe A, Huang J, Kobayashi Y, Sakata I
Neurogastroenterology and motility 2024 Feb;36(2):e14716
Neurogastroenterology and motility 2024 Feb;36(2):e14716
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
He D, Gao X, Wen J, Zhang Y, Yang S, Sun X, Cui M, Li Z, Fu S, Liu J, Liu D
Food & function 2024 Feb 5;15(3):1460-1475
Food & function 2024 Feb 5;15(3):1460-1475
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
Wu S, Qiu C, Ni J, Guo W, Song J, Yang X, Sun Y, Chen Y, Zhu Y, Chang X, Sun P, Wang C, Li K, Han X
Nature communications 2024 Feb 22;15(1):1646
Nature communications 2024 Feb 22;15(1):1646
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone.
Zheng D, Lai Y, Huang K, Guan D, Xie Z, Fu C, Liu L, Huang J, Gong L, Li J, Zhang H, Chen J
International immunopharmacology 2024 Dec 25;143(Pt 3):113608
International immunopharmacology 2024 Dec 25;143(Pt 3):113608
Integrated network pharmacology and transcriptomics to explore the mechanism of compound Dihuang granule (CDG) protects dopaminergic neurons by regulating the Nrf2/HMOX1 pathway in the 6-OHDA/MPP(+)-induced model of Parkinson's disease.
Sun X, Yang S, He Z, Wang L, He J
Chinese medicine 2024 Dec 18;19(1):170
Chinese medicine 2024 Dec 18;19(1):170
Evaluation of the Neuroprotective Effect of Total Glycosides of Cistanche deserticola and Investigation of Novel Brain-Targeting Natural MAO-B Inhibitors.
Zhai X, Xie W, Yaqoob MD, Zhao F, Zhu HZ, Yang SS, Wang K, Wang X, Wang HC, Wang X
ACS chemical neuroscience 2024 Dec 18;15(24):4544-4558
ACS chemical neuroscience 2024 Dec 18;15(24):4544-4558
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Hu J, Lian Z, Weng Z, Xu Z, Gao J, Liu Y, Luo T, Wang X
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547
Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons-Vagus-Macrophage Axis in 70% Partial Hepatectomy of Mice.
Yang L, Zhou Y, Huang Z, Li W, Lin J, Huang W, Sang Y, Wang F, Sun X, Song J, Wu H, Kong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2402856
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2402856
Performance and Microstructure of Grouting Materials Made from Shield Muck.
Wu Z, Ye C, Cao F
Materials (Basel, Switzerland) 2024 Aug 16;17(16)
Materials (Basel, Switzerland) 2024 Aug 16;17(16)
A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease.
Zhang Y, Yin S, Song R, Lai X, Shen M, Wu J, Yan J
Neural regeneration research 2024 Aug 1;19(8):1828-1834
Neural regeneration research 2024 Aug 1;19(8):1828-1834
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model.
Chen R, Li K, Wang Y, Song L, Wang R, Fan W, Zhao N, Zou W, Yang Z, Yan J
Journal of drug targeting 2024 Apr;32(4):423-432
Journal of drug targeting 2024 Apr;32(4):423-432
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Liu G, Li M, Zeng Z, Fan Q, Ren X, Wang Z, Sun Y, He Y, Sun L, Deng Y, Liu S, Zhong C, Gao J
European journal of medical research 2024 Apr 12;29(1):228
European journal of medical research 2024 Apr 12;29(1):228
Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model.
Bao X, Zheng Z, Lv J, Bao J, Chang S, Jiang X, Xin Y
Frontiers in pharmacology 2023;14:1265571
Frontiers in pharmacology 2023;14:1265571
Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP-1 and modulating gut microbiota.
Wu H, Wei J, Zhao X, Liu Y, Chen Z, Wei K, Lu J, Chen W, Jiang M, Li S, Chen T
Bioengineering & translational medicine 2023 Sep;8(5):e10351
Bioengineering & translational medicine 2023 Sep;8(5):e10351
Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors.
Feng Y, Gao C, Xie D, Liu L, Chen B, Liu S, Yang H, Gao Z, Wilson DA, Tu Y, Peng F
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2301736
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2301736
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism.
Qi Y, Zhang Z, Li Y, Zhao G, Huang J, Zhang Y, Xue J, Tang X
Neuromolecular medicine 2023 Sep;25(3):360-374
Neuromolecular medicine 2023 Sep;25(3):360-374
Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.
Kambey PA, Liu WY, Wu J, Bosco B, Nadeem I, Kanwore K, Gao DS
Neural regeneration research 2023 Sep;18(9):2037-2046
Neural regeneration research 2023 Sep;18(9):2037-2046
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Lin Q, Guo Y, Li J, He S, Chen Y, Jin H
Marine drugs 2023 Sep 29;21(10)
Marine drugs 2023 Sep 29;21(10)
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Geng Y, Long X, Zhang Y, Wang Y, You G, Guo W, Zhuang G, Zhang Y, Cheng X, Yuan Z, Zan J
Journal of translational medicine 2023 Sep 22;21(1):652
Journal of translational medicine 2023 Sep 22;21(1):652
Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse.
Lu M, Deng P, Yang L, Wang X, Mei X, Zhou C, Chen M, Zhou Z, Pi H, Wu L, Yu Z
Ecotoxicology and environmental safety 2023 Sep 15;263:115238
Ecotoxicology and environmental safety 2023 Sep 15;263:115238
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Tong Y, Zhu W, Chen J, Zhang W, Xu F, Pang J
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.
Kambey PA, Liu WY, Wu J, Tang C, Buberwa W, Saro A, Nyalali AMK, Gao D
CNS neuroscience & therapeutics 2023 Oct;29(10):2925-2939
CNS neuroscience & therapeutics 2023 Oct;29(10):2925-2939
Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.
Guo X, Wu Y, Wang Q, Zhang J, Sheng X, Zheng L, Wang Y
European journal of pharmacology 2023 Oct 5;956:175970
European journal of pharmacology 2023 Oct 5;956:175970
Anti-inflammatory effects of myristic acid mediated by the NF-κB pathway in lipopolysaccharide-induced BV-2 microglial cells.
Huang Q, Chen C, Zhang Z, Xue Q
Molecular omics 2023 Oct 30;19(9):726-734
Molecular omics 2023 Oct 30;19(9):726-734
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
Wang Y, Wen Q, Chen R, Gan Z, Huang X, Wang P, Cao X, Zhao N, Yang Z, Yan J
Journal of cellular and molecular medicine 2023 Nov;27(22):3614-3627
Journal of cellular and molecular medicine 2023 Nov;27(22):3614-3627
Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson's disease.
Zhang HY, Jiang YC, Li JR, Yan JN, Wang XJ, Shen JB, Ke KF, Gu XS
Neural regeneration research 2023 May;18(5):1099-1106
Neural regeneration research 2023 May;18(5):1099-1106
Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease.
Huang Z, Hu B, Xiang B, Fang H, Zhang B, Wang Y, Zhuo Y, Deng D, Wang X
ACS biomaterials science & engineering 2023 May 8;9(5):2545-2557
ACS biomaterials science & engineering 2023 May 8;9(5):2545-2557
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Fan HX, Sheng S, Li DD, Li JJ, Wang GQ, Zhang F
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Cheng X, Lowin T, Honke N, Pongratz G
Journal of inflammation (London, England) 2023 Mar 14;20(1):9
Journal of inflammation (London, England) 2023 Mar 14;20(1):9
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
Fan JK, Wang MC, Yang HM, Zhang JN, Gu L, Zhang H
Neuromolecular medicine 2023 Jun;25(2):286-300
Neuromolecular medicine 2023 Jun;25(2):286-300
Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.
Wu F, Wei H, Hu Y, Gao J, Xu S
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 15;210(12):1962-1973
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 15;210(12):1962-1973
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Zhang CT, Qin DL, Cao XY, Kan JS, Huang XX, Gao DS, Gao J
iScience 2023 Jul 21;26(7):107049
iScience 2023 Jul 21;26(7):107049
Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice.
Zhou L, Li Y, Wang M, Han W, Chen Q, Zhang J, Sun B, Fan Y
Neuroscience 2023 Jul 15;523:80-90
Neuroscience 2023 Jul 15;523:80-90
ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage.
Yuan Y, Zhang X, Wu Y, Lian P, Cao X, Xu Y
Neuroscience 2023 Jul 15;523:61-79
Neuroscience 2023 Jul 15;523:61-79
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Wang CQ, Su Z, Dai CG, Song JL, Qian B
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Shen K, Wu D, Sun B, Zhu Y, Wang H, Zou W, Ma Y, Lu Z
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
Imperatorin Improves Obesity-Induced Cardiac Sympathetic Nerve Injury Mediated by P2X4 Receptor in Stellate Sympathetic Ganglion.
Zhang M, Wen Y, Liang P, Yang C, Tu H, Wei J, Du J, Zhan T, Liang S, Li G, Gao Y
International journal of molecular sciences 2023 Jan 2;24(1)
International journal of molecular sciences 2023 Jan 2;24(1)
CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.
Ma J, Dong L, Chang Q, Chen S, Zheng J, Li D, Wu S, Yang H, Li X
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166597
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166597
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.
Cheng Y, Tong Q, Yuan Y, Song X, Jiang W, Wang Y, Li W, Li Y, Zhang K
Journal of neuroinflammation 2023 Feb 14;20(1):36
Journal of neuroinflammation 2023 Feb 14;20(1):36
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Guo TT, Zhang Z, Sun Y, Zhu RY, Wang FX, Ma LJ, Jiang L, Liu HD
Nutrients 2023 Feb 13;15(4)
Nutrients 2023 Feb 13;15(4)
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Yu HY, Sun T, Wang Z, Li H, Xu D, An J, Wen LL, Li JY, Li W, Feng J
Neural regeneration research 2023 Aug;18(8):1818-1826
Neural regeneration research 2023 Aug;18(8):1818-1826
Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson's Disease.
Li X, Wang S, Duan S, Long L, Zhuo L, Peng Y, Xiong Y, Li S, Peng X, Yan Y, Wang Z, Jiang W
ACS omega 2023 Aug 8;8(31):28910-28923
ACS omega 2023 Aug 8;8(31):28910-28923
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.
Huang Z, Han J, Wu P, Wu C, Fan Y, Zhao L, Hao X, Chen D, Zhu M
Oxidative medicine and cellular longevity 2022;2022:5463134
Oxidative medicine and cellular longevity 2022;2022:5463134
Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism.
Fan Y, Li M, Wu C, Wu Y, Han J, Wu P, Huang Z, Wang Q, Zhao L, Chen D, Zhu M
Oxidative medicine and cellular longevity 2022;2022:5392966
Oxidative medicine and cellular longevity 2022;2022:5392966
Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.
Yang L, Wang X, Liu X, Chen X
Disease markers 2022;2022:1148191
Disease markers 2022;2022:1148191
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.
Yang X, Liang X, Guo H, Ma L, Jian L, Zhao X, Wang J, Yang L, Meng Z, Jin Q
Open medicine (Warsaw, Poland) 2022;17(1):1031-1044
Open medicine (Warsaw, Poland) 2022;17(1):1031-1044
A zona incerta-basomedial amygdala circuit modulates aversive expectation in emotional stress-induced aversive learning deficits.
Zhang L, Zhang P, Qi G, Cai H, Li T, Li M, Cui C, Lei J, Ren K, Yang J, Ming J, Tian B
Frontiers in cellular neuroscience 2022;16:910699
Frontiers in cellular neuroscience 2022;16:910699
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
Zhong Y, Cai X, Ding L, Liao J, Liu X, Huang Y, Chen X, Long L
Journal of inflammation research 2022;15:669-685
Journal of inflammation research 2022;15:669-685
LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.
Zhang J, Xue B, Jing B, Tian H, Zhang N, Li M, Lu L, Chen L, Diao H, Chen Y, Wang M, Li X
Frontiers in pharmacology 2022;13:961817
Frontiers in pharmacology 2022;13:961817
Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.
Zhang KK, Chen LJ, Li JH, Liu JL, Wang LB, Xu LL, Yang JZ, Li XW, Xie XL, Wang Q
Frontiers in microbiology 2022;13:755189
Frontiers in microbiology 2022;13:755189
Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing.
Liu X, Qi Y, Zhao G, Zhang Z, Cao Y, Li Y, Xue J, Tang X
Neuroscience letters 2022 Sep 25;788:136841
Neuroscience letters 2022 Sep 25;788:136841
Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Guizhi-Fuling Treatment for Myocardial Ischemia.
Duan B, Ye Y, Zhou Z, Han L, Huang F, Li J, Wang Q, Zeng X, Yu X
Chemistry & biodiversity 2022 Oct;19(10):e202200386
Chemistry & biodiversity 2022 Oct;19(10):e202200386
Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling.
Roodsari SK, Cheng Y, Reed KM, Wellman LL, Sanford LD, Kim WK, Guo ML
Biomedicines 2022 May 18;10(5)
Biomedicines 2022 May 18;10(5)
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
Yan JN, Zhang HY, Li JR, Chen Y, Jiang YC, Shen JB, Ke KF, Gu XS
Neural regeneration research 2022 Jun;17(6):1357-1363
Neural regeneration research 2022 Jun;17(6):1357-1363
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Xue J, Li Y, Qi Y, Zhang Z, Tang X
Neurotoxicology 2022 Jul;91:211-217
Neurotoxicology 2022 Jul;91:211-217
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
Li J, Liu H, Wang X, Xia Y, Huang J, Wang T, Lin Z, Xiong N
NPJ Parkinson's disease 2022 Jul 8;8(1):90
NPJ Parkinson's disease 2022 Jul 8;8(1):90
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.
Qi G, Zhang P, Li T, Li M, Zhang Q, He F, Zhang L, Cai H, Lv X, Qiao H, Chen X, Ming J, Tian B
Nature communications 2022 Jan 31;13(1):577
Nature communications 2022 Jan 31;13(1):577
Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.
Uçar B, Stefanova N, Humpel C
Biomolecules 2022 Jan 19;12(2)
Biomolecules 2022 Jan 19;12(2)
Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.
Yan J, Sun W, Shen M, Zhang Y, Jiang M, Liu A, Ma H, Lai X, Wu J
Cell death discovery 2022 Jan 17;8(1):28
Cell death discovery 2022 Jan 17;8(1):28
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308
Translational neuroscience 2022 Jan 1;13(1):301-308
Systematic Input-Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness.
Cai H, Zhang P, Qi G, Zhang L, Li T, Li M, Lv X, Lei J, Ming J, Tian B
Molecular neurobiology 2022 Feb;59(2):856-871
Molecular neurobiology 2022 Feb;59(2):856-871
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.
Grelet S, Fréreux C, Obellianne C, Noguchi K, Howley BV, Dalton AC, Howe PH
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway.
Zhang J, Zhang N, Lei J, Jing B, Li M, Tian H, Xue B, Li X
International immunopharmacology 2022 Dec;113(Pt A):109417
International immunopharmacology 2022 Dec;113(Pt A):109417
Vagus Nerve Stimulation in Early Stage of Acute Myocardial Infarction Prevent Ventricular Arrhythmias and Cardiac Remodeling.
Zhao S, Dai Y, Ning X, Tang M, Zhao Y, Li Z, Zhang S
Frontiers in cardiovascular medicine 2021;8:648910
Frontiers in cardiovascular medicine 2021;8:648910
Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.
Zhou X, Lu J, Wei K, Wei J, Tian P, Yue M, Wang Y, Hong D, Li F, Wang B, Chen T, Fang X
Oxidative medicine and cellular longevity 2021;2021:9424582
Oxidative medicine and cellular longevity 2021;2021:9424582
Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson's Disease.
Huang W, Lv Q, Xiao Y, Zhong Z, Hu B, Yan S, Yan Y, Zhang J, Shi T, Jiang L, Li W, Lu G
Frontiers in neuroscience 2021;15:745815
Frontiers in neuroscience 2021;15:745815
Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala.
Zhang XH, Feng CC, Pei LJ, Zhang YN, Chen L, Wei XQ, Zhou J, Yong Y, Wang K
Frontiers in neuroscience 2021;15:657507
Frontiers in neuroscience 2021;15:657507
Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry.
Zhang X, Chen W, Wu Y, Zeng W, Yuan Y, Cheng C, Yang X, Wang J, Yang X, Xu Y, Lei H, Cao X, Xu Y
Frontiers in aging neuroscience 2021;13:759934
Frontiers in aging neuroscience 2021;13:759934
Calcitriol Alleviates MPP(+)- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Hu J, Wu J, Wan F, Kou L, Yin S, Sun Y, Li Y, Zhou Q, Wang T
Frontiers in aging neuroscience 2021;13:657095
Frontiers in aging neuroscience 2021;13:657095
Edaravone Plays Protective Effects on LPS-Induced Microglia by Switching M1/M2 Phenotypes and Regulating NLRP3 Inflammasome Activation.
Li J, Dai X, Zhou L, Li X, Pan D
Frontiers in pharmacology 2021;12:691773
Frontiers in pharmacology 2021;12:691773
Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.
Zheng CQ, Fan HX, Li XX, Li JJ, Sheng S, Zhang F
Frontiers in immunology 2021;12:683577
Frontiers in immunology 2021;12:683577
Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.
Teng Y, Liu Z, Chen X, Liu Y, Geng F, Le W, Jiang H, Yang L
Journal of cellular and molecular medicine 2021 Sep;25(17):8567-8572
Journal of cellular and molecular medicine 2021 Sep;25(17):8567-8572
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in Parkinson's disease models.
Wu J, Xu X, Zheng L, Mo J, Jin X, Bao Y
International immunopharmacology 2021 Oct;99:108025
International immunopharmacology 2021 Oct;99:108025
Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.
Zhou X, Guo Q, Guo M, Li B, Peng W, Wang D, Ming D, Zheng B
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:742-753
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:742-753
Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion.
He F, Zhang P, Zhang Q, Qi G, Cai H, Li T, Li M, Lu J, Lin J, Ming J, Tian B
Molecular neurobiology 2021 Nov;58(11):5635-5648
Molecular neurobiology 2021 Nov;58(11):5635-5648
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, Ma L, Li T, Chen Q, Wang Y, Wang Y, Feng J, Yin X, Wang X, Han J, Lu C
Redox biology 2021 Nov;47:102156
Redox biology 2021 Nov;47:102156
Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.
Chen H, Teng Y, Chen X, Liu Z, Geng F, Liu Y, Jiang H, Wang Z, Yang L
CNS neuroscience & therapeutics 2021 Nov;27(11):1300-1312
CNS neuroscience & therapeutics 2021 Nov;27(11):1300-1312
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.
Chen YT, Yang QY, Hu Y, Liu XD, de Avila JM, Zhu MJ, Nathanielsz PW, Du M
Nature communications 2021 Nov 25;12(1):6845
Nature communications 2021 Nov 25;12(1):6845
Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.
Wang S, Zhang J, Zhang S, Shi F, Feng D, Feng X
Ecotoxicology and environmental safety 2021 Mar 15;211:111938
Ecotoxicology and environmental safety 2021 Mar 15;211:111938
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Gao H, Wang D, Jiang S, Mao J, Yang X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Ning XL, Li YZ, Huo C, Deng J, Gao C, Zhu KR, Wang M, Wu YX, Yu JL, Ren YL, Luo ZY, Li G, Chen Y, Wang SY, Peng C, Yang LL, Wang ZY, Wu Y, Qian S, Li GB
Journal of medicinal chemistry 2021 Jun 24;64(12):8303-8332
Journal of medicinal chemistry 2021 Jun 24;64(12):8303-8332
Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.
Sun X, Kato H, Sato H, Torio M, Han X, Zhang Y, Hirofuji Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K
Biochemistry and biophysics reports 2021 Jul;26:100968
Biochemistry and biophysics reports 2021 Jul;26:100968
Primary Cilia in Amacrine Cells in Retinal Development.
Ning K, Sendayen BE, Kowal TJ, Wang B, Jones BW, Hu Y, Sun Y
Investigative ophthalmology & visual science 2021 Jul 1;62(9):15
Investigative ophthalmology & visual science 2021 Jul 1;62(9):15
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures.
Ucar B, Kajtez J, Foidl BM, Eigel D, Werner C, Long KR, Emnéus J, Bizeau J, Lomora M, Pandit A, Newland B, Humpel C
Acta biomaterialia 2021 Feb;121:250-262
Acta biomaterialia 2021 Feb;121:250-262
Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity.
Li DD, Wang GQ, Wu Q, Shi JS, Zhang F
Biotechnology and applied biochemistry 2021 Dec;68(6):1501-1507
Biotechnology and applied biochemistry 2021 Dec;68(6):1501-1507
Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.
Lu SF, Wang JM, Yuan J, Yang WX, Chen LY, Zhang T, Jing XY, Zhuang Y, Zhang CS, Fu SP, Yu ML
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2021 Dec;39(6):681-690
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2021 Dec;39(6):681-690
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Xue C, Li X, Ba L, Zhang M, Yang Y, Gao Y, Sun Z, Han Q, Zhao RC
Aging and disease 2021 Aug;12(5):1211-1222
Aging and disease 2021 Aug;12(5):1211-1222
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.
Xia Y, Zhang G, Kou L, Yin S, Han C, Hu J, Wan F, Sun Y, Wu J, Li Y, Huang J, Xiong N, Zhang Z, Wang T
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037
Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish.
Joseph TP, Jagadeesan N, Sai LY, Lin SL, Sahu S, Schachner M
Frontiers in neuroscience 2020;14:458
Frontiers in neuroscience 2020;14:458
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP.
Tan Y, Xu Y, Cheng C, Zheng C, Zeng W, Wang J, Zhang X, Yang X, Wang J, Yang X, Nie S, Cao X
Frontiers in pharmacology 2020;11:183
Frontiers in pharmacology 2020;11:183
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis.
Zhu Y, Huan F, Wang J, Xie X, Yu G, Wang X, Jiang L, Gao R, Xiao H, Ding H, Wang J
ACS chemical neuroscience 2020 Oct 21;11(20):3366-3376
ACS chemical neuroscience 2020 Oct 21;11(20):3366-3376
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Lv R, Du L, Zhou F, Yuan X, Liu X, Zhang L
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model.
Gao MR, Wang M, Jia YY, Tian DD, Liu A, Wang WJ, Yang L, Chen JY, Yang Q, Liu R, Wu YM
Brain research bulletin 2020 Nov;164:55-64
Brain research bulletin 2020 Nov;164:55-64
Fenvalerate triggers Parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK/mTOR signaling pathway.
Zhu J, Xia R, Liu Z, Shen J, Gong X, Hu Y, Chen H, Yu Y, Gao W, Wang C, Wang SL
Chemosphere 2020 Mar;243:125336
Chemosphere 2020 Mar;243:125336
Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson's Disease.
He F, Qi G, Zhang Q, Cai H, Li T, Li M, Zhang Q, Chen J, Ming J, Tian B, Zhang P
Cellular and molecular neurobiology 2020 Aug;40(6):897-909
Cellular and molecular neurobiology 2020 Aug;40(6):897-909
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Fang X, Zhou X, Miao Y, Han Y, Wei J, Chen T
AMB Express 2020 Apr 24;10(1):80
AMB Express 2020 Apr 24;10(1):80
Differences in the number of oxytocin, vasopressin, and tyrosine hydroxylase cells in brain regions associated with mating among great, midday, and Mongolian gerbils.
Yu P, Zhang M, Nan X, Zhao H, Gong D
Brain research 2020 Apr 15;1733:146677
Brain research 2020 Apr 15;1733:146677
Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.
Lin L, Yu L, Xiang H, Hu X, Yuan X, Zhu H, Li H, Zhang H, Hou T, Cao J, Wu S, Su W, Li M
Frontiers in behavioral neuroscience 2019;13:239
Frontiers in behavioral neuroscience 2019;13:239
Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP(+) and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway.
Guo X, Han C, Ma K, Xia Y, Wan F, Yin S, Kou L, Sun Y, Wu J, Hu J, Huang J, Xiong N, Wang T
Frontiers in neurology 2019;10:271
Frontiers in neurology 2019;10:271
The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.
Deng J, Zhou X, Wang M, Wang M, Zhou L, Meng G, Wang Y, Wang Z, Zhang Y, Zhou Z, Yu L, Jiang H
International journal of cardiology 2019 Mar 15;279:64-71
International journal of cardiology 2019 Mar 15;279:64-71
Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder.
Nguyen Nguyen HT, Kato H, Sato H, Yamaza H, Sakai Y, Ohga S, Nonaka K, Masuda K
Biochemical and biophysical research communications 2019 Jun 11;513(4):1048-1054
Biochemical and biophysical research communications 2019 Jun 11;513(4):1048-1054
Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia.
Zhang Q, Hu DX, He F, Li CY, Qi GJ, Cai HW, Li TX, Ming J, Zhang P, Chen XQ, Tian B
Nature communications 2019 Jul 3;10(1):2942
Nature communications 2019 Jul 3;10(1):2942
Microglia as modulators of exosomal alpha-synuclein transmission.
Xia Y, Zhang G, Han C, Ma K, Guo X, Wan F, Kou L, Yin S, Liu L, Huang J, Xiong N, Wang T
Cell death & disease 2019 Feb 20;10(3):174
Cell death & disease 2019 Feb 20;10(3):174
Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β(1-42) level.
Ba F, Zhou Y, Zhou J, Chen X
Molecular and cellular biochemistry 2019 Aug;458(1-2):71-78
Molecular and cellular biochemistry 2019 Aug;458(1-2):71-78
Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1.
Fang X, Tian P, Zhao X, Jiang C, Chen T
Journal of neurochemistry 2019 Aug;150(4):441-452
Journal of neurochemistry 2019 Aug;150(4):441-452
TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.
Zheng C, Chen G, Tan Y, Zeng W, Peng Q, Wang J, Cheng C, Yang X, Nie S, Xu Y, Zhang Z, Papa SM, Ye K, Cao X
Frontiers in cellular neuroscience 2018;12:485
Frontiers in cellular neuroscience 2018;12:485
TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.
Zheng C, Chen G, Tan Y, Zeng W, Peng Q, Wang J, Cheng C, Yang X, Nie S, Xu Y, Zhang Z, Papa SM, Ye K, Cao X
Frontiers in cellular neuroscience 2018;12:417
Frontiers in cellular neuroscience 2018;12:417
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Wang SJ, Wang Q, Ma J, Yu PH, Wang ZM, Wang B
Neural regeneration research 2018 Jan;13(1):112-118
Neural regeneration research 2018 Jan;13(1):112-118
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.
Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, Zhang Q, Guo C, Zhang L, Wang Q
Diabetes 2018 Feb;67(2):235-247
Diabetes 2018 Feb;67(2):235-247
Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo.
Chen H, Xu J, Lv Y, He P, Liu C, Jiao J, Li S, Mao X, Xue X
Molecular medicine reports 2018 Dec;18(6):4913-4921
Molecular medicine reports 2018 Dec;18(6):4913-4921
Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.
Nguyen HTN, Kato H, Masuda K, Yamaza H, Hirofuji Y, Sato H, Pham TTM, Takayama F, Sakai Y, Ohga S, Taguchi T, Nonaka K
Biochemistry and biophysics reports 2018 Dec;16:24-31
Biochemistry and biophysics reports 2018 Dec;16:24-31
Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.
Liu J, Wang F, Liu S, Du J, Hu X, Xiong J, Fang R, Chen W, Sun J
Journal of the neurological sciences 2017 Oct 15;381:176-181
Journal of the neurological sciences 2017 Oct 15;381:176-181
Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.
Hu Q, Guo F, Zhao F, Fu Z
Chemosphere 2017 Apr;173:373-379
Chemosphere 2017 Apr;173:373-379
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- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 25859-1-AP( TH Antibody) at dilution of 1:600
- Other comments
- WB
