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- Antigen structure
- References [128]
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- Product number
- 25859-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#25859-1-AP, RRID:AB_2716568
- Product name
- TH antibody
- Antibody type
- Polyclonal
- Description
- TH antibody (Cat. #25859-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways.
LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
Manganese accumulation in red blood cells as a biomarker of manganese exposure and neurotoxicity.
TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model.
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behaviors via BDNF But Not Norepinephrine.
An artificial protein modulator reprogramming neuronal protein functions.
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson's disease.
Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model.
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
SIRT3-Mediated Deacetylation of SDHA Rescues Mitochondrial Bioenergetics Contributing to Neuroprotection in Rotenone-Induced PD Models.
Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease.
Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease.
Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit.
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.
Involvement of the autonomic nervous system in colonic contractions in conscious Suncus murinus.
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons-Vagus-Macrophage Axis in 70% Partial Hepatectomy of Mice.
A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease.
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model.
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP-1 and modulating gut microbiota.
Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors.
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism.
Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse.
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.
Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.
Anti-inflammatory effects of myristic acid mediated by the NF-κB pathway in lipopolysaccharide-induced BV-2 microglial cells.
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson's disease.
Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease.
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice.
ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage.
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Imperatorin Improves Obesity-Induced Cardiac Sympathetic Nerve Injury Mediated by P2X4 Receptor in Stellate Sympathetic Ganglion.
CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson's Disease.
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.
Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism.
Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.
A zona incerta-basomedial amygdala circuit modulates aversive expectation in emotional stress-induced aversive learning deficits.
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.
Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.
Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing.
Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Guizhi-Fuling Treatment for Myocardial Ischemia.
Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling.
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.
Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.
Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Systematic Input-Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness.
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.
Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway.
Vagus Nerve Stimulation in Early Stage of Acute Myocardial Infarction Prevent Ventricular Arrhythmias and Cardiac Remodeling.
Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.
Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson's Disease.
Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala.
Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry.
Calcitriol Alleviates MPP(+)- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.
Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in Parkinson's disease models.
Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.
Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion.
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.
Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.
Primary Cilia in Amacrine Cells in Retinal Development.
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures.
Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity.
Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.
Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish.
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis.
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model.
Fenvalerate triggers Parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK/mTOR signaling pathway.
Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson's Disease.
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Differences in the number of oxytocin, vasopressin, and tyrosine hydroxylase cells in brain regions associated with mating among great, midday, and Mongolian gerbils.
Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.
Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP(+) and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway.
The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.
Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder.
Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia.
Microglia as modulators of exosomal alpha-synuclein transmission.
Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β(1-42) level.
Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1.
TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.
TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.
Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo.
Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.
Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.
Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.
Wang H, Mao W, Zhang Y, Feng W, Bai B, Ji B, Chen J, Cheng B, Yan F
Free radical biology & medicine 2024 Sep;222:331-343
Free radical biology & medicine 2024 Sep;222:331-343
Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF-κB and Nrf2/HO-1 signaling pathways.
Wang P, Chen C, Shan M
Journal of biochemical and molecular toxicology 2024 May;38(5):e23714
Journal of biochemical and molecular toxicology 2024 May;38(5):e23714
LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease.
Zheng Z, Zhang S, Liu X, Wang X, Xue C, Wu X, Zhang X, Xu X, Liu Z, Yao L, Lu G
Journal of cellular physiology 2024 May;239(5):e31250
Journal of cellular physiology 2024 May;239(5):e31250
Manganese accumulation in red blood cells as a biomarker of manganese exposure and neurotoxicity.
Deng X, Guo Y, Jin X, Si H, Dai K, Deng M, He J, Hao C, Yao W
Neurotoxicology 2024 May;102:1-11
Neurotoxicology 2024 May;102:1-11
TMT-based quantitative proteomics analysis of neuroprotective effects of Forsythoside A on the MPTP-induced Parkinson's disease mouse model.
Niu B, Zhao M, Gao X, Xu J, Yu L
Experimental neurology 2024 Mar;373:114642
Experimental neurology 2024 Mar;373:114642
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behaviors via BDNF But Not Norepinephrine.
Zhang Q, Xue Y, Wei K, Wang H, Ma Y, Wei Y, Fan Y, Gao L, Yao H, Wu F, Ding X, Zhang Q, Ding J, Fan Y, Lu M, Hu G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2303503
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2303503
An artificial protein modulator reprogramming neuronal protein functions.
Lin P, Zhang B, Yang H, Yang S, Xue P, Chen Y, Yu S, Zhang J, Zhang Y, Chen L, Fan C, Li F, Ling D
Nature communications 2024 Mar 6;15(1):2039
Nature communications 2024 Mar 6;15(1):2039
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson's disease.
Yu D, Wang H, Zhai Y, Lei Z, Sun M, Chen S, Yin P, Wang X
Biological research 2024 Mar 16;57(1):9
Biological research 2024 Mar 16;57(1):9
Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model.
Zhang Z, Wang R, Zhou H, Wu D, Cao Y, Zhang C, Sun H, Mu C, Hao Z, Ren H, Wang N, Yu S, Zhang J, Tao M, Wang C, Liu Y, Liu L, Liu Y, Zang J, Wang G
Cellular and molecular life sciences : CMLS 2024 Mar 12;81(1):128
Cellular and molecular life sciences : CMLS 2024 Mar 12;81(1):128
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Yang R, Li DD, Li XX, Yang XX, Gao HM, Zhang F
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
International journal of biological macromolecules 2024 Jun;269(Pt 2):132179
Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
Cao XY, Liu Y, Kan JS, Huang XX, Kambey PA, Zhang CT, Gao J
Brain research bulletin 2024 Jun 15;212:110970
Brain research bulletin 2024 Jun 15;212:110970
SIRT3-Mediated Deacetylation of SDHA Rescues Mitochondrial Bioenergetics Contributing to Neuroprotection in Rotenone-Induced PD Models.
Shen Y, Wang X, Nan N, Fu X, Zeng R, Yang Y, Xian S, Shi J, Wu Q, Zhou S
Molecular neurobiology 2024 Jul;61(7):4402-4420
Molecular neurobiology 2024 Jul;61(7):4402-4420
Selenium nanoparticles decorated with polysaccharides from Sargassum fusiforme protects against 6-OHDA-induced neurotoxicity in PC12 cells and rat model of Parkinson's disease.
Zhao H, Song J, Wang T, Fan X
Nanomedicine : nanotechnology, biology, and medicine 2024 Jul;59:102755
Nanomedicine : nanotechnology, biology, and medicine 2024 Jul;59:102755
Knockdown of IRF8 alleviates neuroinflammation through regulating microglial activation in Parkinson's disease.
Ma L, Mi N, Wang Z, Bao R, Fang J, Ren Y, Xu X, Zhang H, Tang Y
Journal of chemical neuroanatomy 2024 Jul;138:102424
Journal of chemical neuroanatomy 2024 Jul;138:102424
Alternating bilateral sensory stimulation alleviates alcohol-induced conditioned place preference via a superior colliculus-VTA circuit.
Lei J, Zhang P, Li T, Cui C, Li M, Yang X, Peng X, Ren K, Yang J, Shi Y, Luo G, Yao Y, Tian B
Cell reports 2024 Jul 23;43(7):114383
Cell reports 2024 Jul 23;43(7):114383
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Liu Y, Duan R, Li P, Zhang B, Liu Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway.
Huang W, Wang Y, Huang W
Neuroscience letters 2024 Jan 31;821:137608
Neuroscience letters 2024 Jan 31;821:137608
Involvement of the autonomic nervous system in colonic contractions in conscious Suncus murinus.
Suzuki M, Watanabe A, Huang J, Kobayashi Y, Sakata I
Neurogastroenterology and motility 2024 Feb;36(2):e14716
Neurogastroenterology and motility 2024 Feb;36(2):e14716
Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice.
He D, Gao X, Wen J, Zhang Y, Yang S, Sun X, Cui M, Li Z, Fu S, Liu J, Liu D
Food & function 2024 Feb 5;15(3):1460-1475
Food & function 2024 Feb 5;15(3):1460-1475
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
Wu S, Qiu C, Ni J, Guo W, Song J, Yang X, Sun Y, Chen Y, Zhu Y, Chang X, Sun P, Wang C, Li K, Han X
Nature communications 2024 Feb 22;15(1):1646
Nature communications 2024 Feb 22;15(1):1646
Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.
Hu J, Lian Z, Weng Z, Xu Z, Gao J, Liu Y, Luo T, Wang X
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547
Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons-Vagus-Macrophage Axis in 70% Partial Hepatectomy of Mice.
Yang L, Zhou Y, Huang Z, Li W, Lin J, Huang W, Sang Y, Wang F, Sun X, Song J, Wu H, Kong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2402856
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2402856
A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease.
Zhang Y, Yin S, Song R, Lai X, Shen M, Wu J, Yan J
Neural regeneration research 2024 Aug 1;19(8):1828-1834
Neural regeneration research 2024 Aug 1;19(8):1828-1834
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson's disease mouse model.
Chen R, Li K, Wang Y, Song L, Wang R, Fan W, Zhao N, Zou W, Yang Z, Yan J
Journal of drug targeting 2024 Apr;32(4):423-432
Journal of drug targeting 2024 Apr;32(4):423-432
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling.
Liu G, Li M, Zeng Z, Fan Q, Ren X, Wang Z, Sun Y, He Y, Sun L, Deng Y, Liu S, Zhong C, Gao J
European journal of medical research 2024 Apr 12;29(1):228
European journal of medical research 2024 Apr 12;29(1):228
Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP-1 and modulating gut microbiota.
Wu H, Wei J, Zhao X, Liu Y, Chen Z, Wei K, Lu J, Chen W, Jiang M, Li S, Chen T
Bioengineering & translational medicine 2023 Sep;8(5):e10351
Bioengineering & translational medicine 2023 Sep;8(5):e10351
Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors.
Feng Y, Gao C, Xie D, Liu L, Chen B, Liu S, Yang H, Gao Z, Wilson DA, Tu Y, Peng F
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2301736
Advanced materials (Deerfield Beach, Fla.) 2023 Sep;35(35):e2301736
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism.
Qi Y, Zhang Z, Li Y, Zhao G, Huang J, Zhang Y, Xue J, Tang X
Neuromolecular medicine 2023 Sep;25(3):360-374
Neuromolecular medicine 2023 Sep;25(3):360-374
Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.
Kambey PA, Liu WY, Wu J, Bosco B, Nadeem I, Kanwore K, Gao DS
Neural regeneration research 2023 Sep;18(9):2037-2046
Neural regeneration research 2023 Sep;18(9):2037-2046
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Lin Q, Guo Y, Li J, He S, Chen Y, Jin H
Marine drugs 2023 Sep 29;21(10)
Marine drugs 2023 Sep 29;21(10)
FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.
Geng Y, Long X, Zhang Y, Wang Y, You G, Guo W, Zhuang G, Zhang Y, Cheng X, Yuan Z, Zan J
Journal of translational medicine 2023 Sep 22;21(1):652
Journal of translational medicine 2023 Sep 22;21(1):652
Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse.
Lu M, Deng P, Yang L, Wang X, Mei X, Zhou C, Chen M, Zhou Z, Pi H, Wu L, Yu Z
Ecotoxicology and environmental safety 2023 Sep 15;263:115238
Ecotoxicology and environmental safety 2023 Sep 15;263:115238
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Tong Y, Zhu W, Chen J, Zhang W, Xu F, Pang J
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.
Kambey PA, Liu WY, Wu J, Tang C, Buberwa W, Saro A, Nyalali AMK, Gao D
CNS neuroscience & therapeutics 2023 Oct;29(10):2925-2939
CNS neuroscience & therapeutics 2023 Oct;29(10):2925-2939
Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.
Guo X, Wu Y, Wang Q, Zhang J, Sheng X, Zheng L, Wang Y
European journal of pharmacology 2023 Oct 5;956:175970
European journal of pharmacology 2023 Oct 5;956:175970
Anti-inflammatory effects of myristic acid mediated by the NF-κB pathway in lipopolysaccharide-induced BV-2 microglial cells.
Huang Q, Chen C, Zhang Z, Xue Q
Molecular omics 2023 Oct 30;19(9):726-734
Molecular omics 2023 Oct 30;19(9):726-734
Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
Wang Y, Wen Q, Chen R, Gan Z, Huang X, Wang P, Cao X, Zhao N, Yang Z, Yan J
Journal of cellular and molecular medicine 2023 Nov;27(22):3614-3627
Journal of cellular and molecular medicine 2023 Nov;27(22):3614-3627
Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson's disease.
Zhang HY, Jiang YC, Li JR, Yan JN, Wang XJ, Shen JB, Ke KF, Gu XS
Neural regeneration research 2023 May;18(5):1099-1106
Neural regeneration research 2023 May;18(5):1099-1106
Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease.
Huang Z, Hu B, Xiang B, Fang H, Zhang B, Wang Y, Zhuo Y, Deng D, Wang X
ACS biomaterials science & engineering 2023 May 8;9(5):2545-2557
ACS biomaterials science & engineering 2023 May 8;9(5):2545-2557
Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.
Fan HX, Sheng S, Li DD, Li JJ, Wang GQ, Zhang F
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Bioengineering & translational medicine 2023 Mar;8(2):e10455
Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?
Cheng X, Lowin T, Honke N, Pongratz G
Journal of inflammation (London, England) 2023 Mar 14;20(1):9
Journal of inflammation (London, England) 2023 Mar 14;20(1):9
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.
Fan JK, Wang MC, Yang HM, Zhang JN, Gu L, Zhang H
Neuromolecular medicine 2023 Jun;25(2):286-300
Neuromolecular medicine 2023 Jun;25(2):286-300
Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.
Wu F, Wei H, Hu Y, Gao J, Xu S
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 15;210(12):1962-1973
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 15;210(12):1962-1973
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Zhang CT, Qin DL, Cao XY, Kan JS, Huang XX, Gao DS, Gao J
iScience 2023 Jul 21;26(7):107049
iScience 2023 Jul 21;26(7):107049
Disruption of α-Synuclein Proteostasis in the Striatum and Midbrain of Long-term Ovariectomized Female Mice.
Zhou L, Li Y, Wang M, Han W, Chen Q, Zhang J, Sun B, Fan Y
Neuroscience 2023 Jul 15;523:80-90
Neuroscience 2023 Jul 15;523:80-90
ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage.
Yuan Y, Zhang X, Wu Y, Lian P, Cao X, Xu Y
Neuroscience 2023 Jul 15;523:61-79
Neuroscience 2023 Jul 15;523:61-79
Multi-omics analysis reveals BDE47 induces depression-like behaviors in mice by interfering with the 2-arachidonoyl glycerol-associated microbiota-gut-brain axis.
Wang CQ, Su Z, Dai CG, Song JL, Qian B
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Ecotoxicology and environmental safety 2023 Jul 1;259:115041
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Shen K, Wu D, Sun B, Zhu Y, Wang H, Zou W, Ma Y, Lu Z
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
Imperatorin Improves Obesity-Induced Cardiac Sympathetic Nerve Injury Mediated by P2X4 Receptor in Stellate Sympathetic Ganglion.
Zhang M, Wen Y, Liang P, Yang C, Tu H, Wei J, Du J, Zhan T, Liang S, Li G, Gao Y
International journal of molecular sciences 2023 Jan 2;24(1)
International journal of molecular sciences 2023 Jan 2;24(1)
CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.
Ma J, Dong L, Chang Q, Chen S, Zheng J, Li D, Wu S, Yang H, Li X
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166597
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166597
PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.
Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200
α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.
Cheng Y, Tong Q, Yuan Y, Song X, Jiang W, Wang Y, Li W, Li Y, Zhang K
Journal of neuroinflammation 2023 Feb 14;20(1):36
Journal of neuroinflammation 2023 Feb 14;20(1):36
Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.
Guo TT, Zhang Z, Sun Y, Zhu RY, Wang FX, Ma LJ, Jiang L, Liu HD
Nutrients 2023 Feb 13;15(4)
Nutrients 2023 Feb 13;15(4)
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.
Yu HY, Sun T, Wang Z, Li H, Xu D, An J, Wen LL, Li JY, Li W, Feng J
Neural regeneration research 2023 Aug;18(8):1818-1826
Neural regeneration research 2023 Aug;18(8):1818-1826
Exploring the Therapeutic Effects of Multifunctional N-Salicylic Acid Tryptamine Derivative against Parkinson's Disease.
Li X, Wang S, Duan S, Long L, Zhuo L, Peng Y, Xiong Y, Li S, Peng X, Yan Y, Wang Z, Jiang W
ACS omega 2023 Aug 8;8(31):28910-28923
ACS omega 2023 Aug 8;8(31):28910-28923
Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.
Huang Z, Han J, Wu P, Wu C, Fan Y, Zhao L, Hao X, Chen D, Zhu M
Oxidative medicine and cellular longevity 2022;2022:5463134
Oxidative medicine and cellular longevity 2022;2022:5463134
Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism.
Fan Y, Li M, Wu C, Wu Y, Han J, Wu P, Huang Z, Wang Q, Zhao L, Chen D, Zhu M
Oxidative medicine and cellular longevity 2022;2022:5392966
Oxidative medicine and cellular longevity 2022;2022:5392966
Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.
Yang L, Wang X, Liu X, Chen X
Disease markers 2022;2022:1148191
Disease markers 2022;2022:1148191
β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.
Yang X, Liang X, Guo H, Ma L, Jian L, Zhao X, Wang J, Yang L, Meng Z, Jin Q
Open medicine (Warsaw, Poland) 2022;17(1):1031-1044
Open medicine (Warsaw, Poland) 2022;17(1):1031-1044
A zona incerta-basomedial amygdala circuit modulates aversive expectation in emotional stress-induced aversive learning deficits.
Zhang L, Zhang P, Qi G, Cai H, Li T, Li M, Cui C, Lei J, Ren K, Yang J, Ming J, Tian B
Frontiers in cellular neuroscience 2022;16:910699
Frontiers in cellular neuroscience 2022;16:910699
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
Zhong Y, Cai X, Ding L, Liao J, Liu X, Huang Y, Chen X, Long L
Journal of inflammation research 2022;15:669-685
Journal of inflammation research 2022;15:669-685
LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.
Zhang J, Xue B, Jing B, Tian H, Zhang N, Li M, Lu L, Chen L, Diao H, Chen Y, Wang M, Li X
Frontiers in pharmacology 2022;13:961817
Frontiers in pharmacology 2022;13:961817
Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.
Zhang KK, Chen LJ, Li JH, Liu JL, Wang LB, Xu LL, Yang JZ, Li XW, Xie XL, Wang Q
Frontiers in microbiology 2022;13:755189
Frontiers in microbiology 2022;13:755189
Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing.
Liu X, Qi Y, Zhao G, Zhang Z, Cao Y, Li Y, Xue J, Tang X
Neuroscience letters 2022 Sep 25;788:136841
Neuroscience letters 2022 Sep 25;788:136841
Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Guizhi-Fuling Treatment for Myocardial Ischemia.
Duan B, Ye Y, Zhou Z, Han L, Huang F, Li J, Wang Q, Zeng X, Yu X
Chemistry & biodiversity 2022 Oct;19(10):e202200386
Chemistry & biodiversity 2022 Oct;19(10):e202200386
Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling.
Roodsari SK, Cheng Y, Reed KM, Wellman LL, Sanford LD, Kim WK, Guo ML
Biomedicines 2022 May 18;10(5)
Biomedicines 2022 May 18;10(5)
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.
Yan JN, Zhang HY, Li JR, Chen Y, Jiang YC, Shen JB, Ke KF, Gu XS
Neural regeneration research 2022 Jun;17(6):1357-1363
Neural regeneration research 2022 Jun;17(6):1357-1363
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T
Journal of neuroinflammation 2022 Jun 6;19(1):133
Journal of neuroinflammation 2022 Jun 6;19(1):133
Exogenous Otx2 protects midbrain dopaminergic neurons from MPP(+) by interacting with ATP5a1 and promoting ATP synthesis.
Xue J, Li Y, Qi Y, Zhang Z, Tang X
Neurotoxicology 2022 Jul;91:211-217
Neurotoxicology 2022 Jul;91:211-217
Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.
Li J, Liu H, Wang X, Xia Y, Huang J, Wang T, Lin Z, Xiong N
NPJ Parkinson's disease 2022 Jul 8;8(1):90
NPJ Parkinson's disease 2022 Jul 8;8(1):90
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.
Qi G, Zhang P, Li T, Li M, Zhang Q, He F, Zhang L, Cai H, Lv X, Qiao H, Chen X, Ming J, Tian B
Nature communications 2022 Jan 31;13(1):577
Nature communications 2022 Jan 31;13(1):577
Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.
Uçar B, Stefanova N, Humpel C
Biomolecules 2022 Jan 19;12(2)
Biomolecules 2022 Jan 19;12(2)
Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.
Yan J, Sun W, Shen M, Zhang Y, Jiang M, Liu A, Ma H, Lai X, Wu J
Cell death discovery 2022 Jan 17;8(1):28
Cell death discovery 2022 Jan 17;8(1):28
Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.
Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308
Translational neuroscience 2022 Jan 1;13(1):301-308
Systematic Input-Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness.
Cai H, Zhang P, Qi G, Zhang L, Li T, Li M, Lv X, Lei J, Ming J, Tian B
Molecular neurobiology 2022 Feb;59(2):856-871
Molecular neurobiology 2022 Feb;59(2):856-871
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.
Grelet S, Fréreux C, Obellianne C, Noguchi K, Howley BV, Dalton AC, Howe PH
Life science alliance 2022 Feb;5(2)
Life science alliance 2022 Feb;5(2)
Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway.
Zhang J, Zhang N, Lei J, Jing B, Li M, Tian H, Xue B, Li X
International immunopharmacology 2022 Dec;113(Pt A):109417
International immunopharmacology 2022 Dec;113(Pt A):109417
Vagus Nerve Stimulation in Early Stage of Acute Myocardial Infarction Prevent Ventricular Arrhythmias and Cardiac Remodeling.
Zhao S, Dai Y, Ning X, Tang M, Zhao Y, Li Z, Zhang S
Frontiers in cardiovascular medicine 2021;8:648910
Frontiers in cardiovascular medicine 2021;8:648910
Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.
Zhou X, Lu J, Wei K, Wei J, Tian P, Yue M, Wang Y, Hong D, Li F, Wang B, Chen T, Fang X
Oxidative medicine and cellular longevity 2021;2021:9424582
Oxidative medicine and cellular longevity 2021;2021:9424582
Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson's Disease.
Huang W, Lv Q, Xiao Y, Zhong Z, Hu B, Yan S, Yan Y, Zhang J, Shi T, Jiang L, Li W, Lu G
Frontiers in neuroscience 2021;15:745815
Frontiers in neuroscience 2021;15:745815
Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala.
Zhang XH, Feng CC, Pei LJ, Zhang YN, Chen L, Wei XQ, Zhou J, Yong Y, Wang K
Frontiers in neuroscience 2021;15:657507
Frontiers in neuroscience 2021;15:657507
Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry.
Zhang X, Chen W, Wu Y, Zeng W, Yuan Y, Cheng C, Yang X, Wang J, Yang X, Xu Y, Lei H, Cao X, Xu Y
Frontiers in aging neuroscience 2021;13:759934
Frontiers in aging neuroscience 2021;13:759934
Calcitriol Alleviates MPP(+)- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.
Hu J, Wu J, Wan F, Kou L, Yin S, Sun Y, Li Y, Zhou Q, Wang T
Frontiers in aging neuroscience 2021;13:657095
Frontiers in aging neuroscience 2021;13:657095
Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.
Zheng CQ, Fan HX, Li XX, Li JJ, Sheng S, Zhang F
Frontiers in immunology 2021;12:683577
Frontiers in immunology 2021;12:683577
Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.
Teng Y, Liu Z, Chen X, Liu Y, Geng F, Le W, Jiang H, Yang L
Journal of cellular and molecular medicine 2021 Sep;25(17):8567-8572
Journal of cellular and molecular medicine 2021 Sep;25(17):8567-8572
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Molecules (Basel, Switzerland) 2021 Sep 13;26(18)
Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in Parkinson's disease models.
Wu J, Xu X, Zheng L, Mo J, Jin X, Bao Y
International immunopharmacology 2021 Oct;99:108025
International immunopharmacology 2021 Oct;99:108025
Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.
Zhou X, Guo Q, Guo M, Li B, Peng W, Wang D, Ming D, Zheng B
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:742-753
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:742-753
Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion.
He F, Zhang P, Zhang Q, Qi G, Cai H, Li T, Li M, Lu J, Lin J, Ming J, Tian B
Molecular neurobiology 2021 Nov;58(11):5635-5648
Molecular neurobiology 2021 Nov;58(11):5635-5648
Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.
Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, Ma L, Li T, Chen Q, Wang Y, Wang Y, Feng J, Yin X, Wang X, Han J, Lu C
Redox biology 2021 Nov;47:102156
Redox biology 2021 Nov;47:102156
Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.
Chen H, Teng Y, Chen X, Liu Z, Geng F, Liu Y, Jiang H, Wang Z, Yang L
CNS neuroscience & therapeutics 2021 Nov;27(11):1300-1312
CNS neuroscience & therapeutics 2021 Nov;27(11):1300-1312
Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.
Chen YT, Yang QY, Hu Y, Liu XD, de Avila JM, Zhu MJ, Nathanielsz PW, Du M
Nature communications 2021 Nov 25;12(1):6845
Nature communications 2021 Nov 25;12(1):6845
Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.
Wang S, Zhang J, Zhang S, Shi F, Feng D, Feng X
Ecotoxicology and environmental safety 2021 Mar 15;211:111938
Ecotoxicology and environmental safety 2021 Mar 15;211:111938
NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.
Gao H, Wang D, Jiang S, Mao J, Yang X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Ning XL, Li YZ, Huo C, Deng J, Gao C, Zhu KR, Wang M, Wu YX, Yu JL, Ren YL, Luo ZY, Li G, Chen Y, Wang SY, Peng C, Yang LL, Wang ZY, Wu Y, Qian S, Li GB
Journal of medicinal chemistry 2021 Jun 24;64(12):8303-8332
Journal of medicinal chemistry 2021 Jun 24;64(12):8303-8332
Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.
Sun X, Kato H, Sato H, Torio M, Han X, Zhang Y, Hirofuji Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K
Biochemistry and biophysics reports 2021 Jul;26:100968
Biochemistry and biophysics reports 2021 Jul;26:100968
Primary Cilia in Amacrine Cells in Retinal Development.
Ning K, Sendayen BE, Kowal TJ, Wang B, Jones BW, Hu Y, Sun Y
Investigative ophthalmology & visual science 2021 Jul 1;62(9):15
Investigative ophthalmology & visual science 2021 Jul 1;62(9):15
Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.
Chen LJ, Zhi X, Zhang KK, Wang LB, Li JH, Liu JL, Xu LL, Yoshida JS, Xie XL, Wang Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111946
Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures.
Ucar B, Kajtez J, Foidl BM, Eigel D, Werner C, Long KR, Emnéus J, Bizeau J, Lomora M, Pandit A, Newland B, Humpel C
Acta biomaterialia 2021 Feb;121:250-262
Acta biomaterialia 2021 Feb;121:250-262
Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity.
Li DD, Wang GQ, Wu Q, Shi JS, Zhang F
Biotechnology and applied biochemistry 2021 Dec;68(6):1501-1507
Biotechnology and applied biochemistry 2021 Dec;68(6):1501-1507
Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.
Lu SF, Wang JM, Yuan J, Yang WX, Chen LY, Zhang T, Jing XY, Zhuang Y, Zhang CS, Fu SP, Yu ML
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2021 Dec;39(6):681-690
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2021 Dec;39(6):681-690
MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.
Xue C, Li X, Ba L, Zhang M, Yang Y, Gao Y, Sun Z, Han Q, Zhao RC
Aging and disease 2021 Aug;12(5):1211-1222
Aging and disease 2021 Aug;12(5):1211-1222
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.
Xia Y, Zhang G, Kou L, Yin S, Han C, Hu J, Wan F, Sun Y, Wu J, Li Y, Huang J, Xiong N, Zhang Z, Wang T
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037
Brain : a journal of neurology 2021 Aug 17;144(7):2024-2037
Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish.
Joseph TP, Jagadeesan N, Sai LY, Lin SL, Sahu S, Schachner M
Frontiers in neuroscience 2020;14:458
Frontiers in neuroscience 2020;14:458
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP.
Tan Y, Xu Y, Cheng C, Zheng C, Zeng W, Wang J, Zhang X, Yang X, Wang J, Yang X, Nie S, Cao X
Frontiers in pharmacology 2020;11:183
Frontiers in pharmacology 2020;11:183
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis.
Zhu Y, Huan F, Wang J, Xie X, Yu G, Wang X, Jiang L, Gao R, Xiao H, Ding H, Wang J
ACS chemical neuroscience 2020 Oct 21;11(20):3366-3376
ACS chemical neuroscience 2020 Oct 21;11(20):3366-3376
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Lv R, Du L, Zhou F, Yuan X, Liu X, Zhang L
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model.
Gao MR, Wang M, Jia YY, Tian DD, Liu A, Wang WJ, Yang L, Chen JY, Yang Q, Liu R, Wu YM
Brain research bulletin 2020 Nov;164:55-64
Brain research bulletin 2020 Nov;164:55-64
Fenvalerate triggers Parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK/mTOR signaling pathway.
Zhu J, Xia R, Liu Z, Shen J, Gong X, Hu Y, Chen H, Yu Y, Gao W, Wang C, Wang SL
Chemosphere 2020 Mar;243:125336
Chemosphere 2020 Mar;243:125336
Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson's Disease.
He F, Qi G, Zhang Q, Cai H, Li T, Li M, Zhang Q, Chen J, Ming J, Tian B, Zhang P
Cellular and molecular neurobiology 2020 Aug;40(6):897-909
Cellular and molecular neurobiology 2020 Aug;40(6):897-909
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
Fang X, Zhou X, Miao Y, Han Y, Wei J, Chen T
AMB Express 2020 Apr 24;10(1):80
AMB Express 2020 Apr 24;10(1):80
Differences in the number of oxytocin, vasopressin, and tyrosine hydroxylase cells in brain regions associated with mating among great, midday, and Mongolian gerbils.
Yu P, Zhang M, Nan X, Zhao H, Gong D
Brain research 2020 Apr 15;1733:146677
Brain research 2020 Apr 15;1733:146677
Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.
Lin L, Yu L, Xiang H, Hu X, Yuan X, Zhu H, Li H, Zhang H, Hou T, Cao J, Wu S, Su W, Li M
Frontiers in behavioral neuroscience 2019;13:239
Frontiers in behavioral neuroscience 2019;13:239
Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP(+) and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway.
Guo X, Han C, Ma K, Xia Y, Wan F, Yin S, Kou L, Sun Y, Wu J, Hu J, Huang J, Xiong N, Wang T
Frontiers in neurology 2019;10:271
Frontiers in neurology 2019;10:271
The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.
Deng J, Zhou X, Wang M, Wang M, Zhou L, Meng G, Wang Y, Wang Z, Zhang Y, Zhou Z, Yu L, Jiang H
International journal of cardiology 2019 Mar 15;279:64-71
International journal of cardiology 2019 Mar 15;279:64-71
Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder.
Nguyen Nguyen HT, Kato H, Sato H, Yamaza H, Sakai Y, Ohga S, Nonaka K, Masuda K
Biochemical and biophysical research communications 2019 Jun 11;513(4):1048-1054
Biochemical and biophysical research communications 2019 Jun 11;513(4):1048-1054
Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia.
Zhang Q, Hu DX, He F, Li CY, Qi GJ, Cai HW, Li TX, Ming J, Zhang P, Chen XQ, Tian B
Nature communications 2019 Jul 3;10(1):2942
Nature communications 2019 Jul 3;10(1):2942
Microglia as modulators of exosomal alpha-synuclein transmission.
Xia Y, Zhang G, Han C, Ma K, Guo X, Wan F, Kou L, Yin S, Liu L, Huang J, Xiong N, Wang T
Cell death & disease 2019 Feb 20;10(3):174
Cell death & disease 2019 Feb 20;10(3):174
Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β(1-42) level.
Ba F, Zhou Y, Zhou J, Chen X
Molecular and cellular biochemistry 2019 Aug;458(1-2):71-78
Molecular and cellular biochemistry 2019 Aug;458(1-2):71-78
Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1.
Fang X, Tian P, Zhao X, Jiang C, Chen T
Journal of neurochemistry 2019 Aug;150(4):441-452
Journal of neurochemistry 2019 Aug;150(4):441-452
TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.
Zheng C, Chen G, Tan Y, Zeng W, Peng Q, Wang J, Cheng C, Yang X, Nie S, Xu Y, Zhang Z, Papa SM, Ye K, Cao X
Frontiers in cellular neuroscience 2018;12:485
Frontiers in cellular neuroscience 2018;12:485
TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.
Zheng C, Chen G, Tan Y, Zeng W, Peng Q, Wang J, Cheng C, Yang X, Nie S, Xu Y, Zhang Z, Papa SM, Ye K, Cao X
Frontiers in cellular neuroscience 2018;12:417
Frontiers in cellular neuroscience 2018;12:417
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.
Wang SJ, Wang Q, Ma J, Yu PH, Wang ZM, Wang B
Neural regeneration research 2018 Jan;13(1):112-118
Neural regeneration research 2018 Jan;13(1):112-118
Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.
Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, Zhang Q, Guo C, Zhang L, Wang Q
Diabetes 2018 Feb;67(2):235-247
Diabetes 2018 Feb;67(2):235-247
Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo.
Chen H, Xu J, Lv Y, He P, Liu C, Jiao J, Li S, Mao X, Xue X
Molecular medicine reports 2018 Dec;18(6):4913-4921
Molecular medicine reports 2018 Dec;18(6):4913-4921
Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.
Nguyen HTN, Kato H, Masuda K, Yamaza H, Hirofuji Y, Sato H, Pham TTM, Takayama F, Sakai Y, Ohga S, Taguchi T, Nonaka K
Biochemistry and biophysics reports 2018 Dec;16:24-31
Biochemistry and biophysics reports 2018 Dec;16:24-31
Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.
Liu J, Wang F, Liu S, Du J, Hu X, Xiong J, Fang R, Chen W, Sun J
Journal of the neurological sciences 2017 Oct 15;381:176-181
Journal of the neurological sciences 2017 Oct 15;381:176-181
Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.
Hu Q, Guo F, Zhao F, Fu Z
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Chemosphere 2017 Apr;173:373-379
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 25859-1-AP( TH Antibody) at dilution of 1:600
- Other comments
- WB
