NBP2-29463
antibody from Novus Biologicals
Targeting: CDKN1A
CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1
Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- NBP2-29463 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal p21/CIP1/CDKN1A Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). In ELISA, MAb WA-1 is useful either as a solid phase or for detection of p21 protein.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C.
Submitted references Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells.
Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance.
DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome.
Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.
Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis.
Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation.
E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures.
Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins.
Acrylonitrile exposure: the effect on p53 and p21(WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts.
Acrylonitrile exposure: the effect on p53 and p21(WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts.
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.
Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.
Observation of Delta|k - l | = 3 Transitions in the nu3 Band of H3 O+
Couture R, Mora N, Al Bittar S, Najih M, Touaibia M, Martin LJ
Cell biology and toxicology 2020 Feb;36(1):31-49
Cell biology and toxicology 2020 Feb;36(1):31-49
Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Aratani S, Tagawa M, Nagasaka S, Sakai Y, Shimizu A, Tsuruoka S
Scientific reports 2018 Nov 14;8(1):16812
Scientific reports 2018 Nov 14;8(1):16812
Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance.
Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H
Bioorganic & medicinal chemistry 2017 Sep 1;25(17):4686-4700
Bioorganic & medicinal chemistry 2017 Sep 1;25(17):4686-4700
DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome.
Xiang J, Yang S, Xin N, Gaertig MA, Reeves RH, Li S, Li XJ
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 14;114(7):E1224-E1233
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 14;114(7):E1224-E1233
Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.
Ge X, Pettan-Brewer C, Morton J, Carter K, Fatemi S, Rabinovitch P, Ladiges WC
Pathobiology of aging & age related diseases 2015;5:28776
Pathobiology of aging & age related diseases 2015;5:28776
Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis.
Romanov VS, Pospelov VA, Pospelova TV
Biochemistry. Biokhimiia 2012 Jun;77(6):575-84
Biochemistry. Biokhimiia 2012 Jun;77(6):575-84
Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation.
Koike M, Yutoku Y, Koike A
Biochemical and biophysical research communications 2011 Aug 19;412(1):39-43
Biochemical and biophysical research communications 2011 Aug 19;412(1):39-43
E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures.
Nobre RJ, Herráez-Hernández E, Fei JW, Langbein L, Kaden S, Gröne HJ, de Villiers EM
Journal of virology 2009 Apr;83(7):2907-16
Journal of virology 2009 Apr;83(7):2907-16
Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins.
Rossner P Jr, Binkova B, Milcova A, Solansky I, Zidzik J, Lyubomirova KD, Farmer PB, Sram RJ
Mutation research 2007 Jul 1;620(1-2):34-40
Mutation research 2007 Jul 1;620(1-2):34-40
Acrylonitrile exposure: the effect on p53 and p21(WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts.
Rössner P Jr, Binková B, Chvátalová I, Srám RJ
Mutation research 2002 May 27;517(1-2):239-50
Mutation research 2002 May 27;517(1-2):239-50
Acrylonitrile exposure: the effect on p53 and p21(WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts.
Rössner P Jr, Binková B, Chvátalová I, Srám RJ
Mutation research 2002 May 27;517(1-2):239-50
Mutation research 2002 May 27;517(1-2):239-50
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.
Scott MT, Ingram A, Ball KL
The EMBO journal 2002 Dec 16;21(24):6771-80
The EMBO journal 2002 Dec 16;21(24):6771-80
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.
Scott MT, Ingram A, Ball KL
The EMBO journal 2002 Dec 16;21(24):6771-80
The EMBO journal 2002 Dec 16;21(24):6771-80
Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.
Blaydes JP, Luciani MG, Pospisilova S, Ball HM, Vojtesek B, Hupp TR
The Journal of biological chemistry 2001 Feb 16;276(7):4699-708
The Journal of biological chemistry 2001 Feb 16;276(7):4699-708
Observation of Delta|k - l | = 3 Transitions in the nu3 Band of H3 O+
Uy D, White ET, Oka T
Journal of molecular spectroscopy 1997 Jun;183(2):240-4
Journal of molecular spectroscopy 1997 Jun;183(2):240-4
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: p21/CIP1/CDKN1A Antibody (WA-1 (HJ21)) [NBP2-29463] - Formalin-fixed, paraffin-embedded human bladder carcinoma stained with p21 Monoclonal Antibody (WA-1).