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Learn10355-1-AP
antibody from Proteintech Group
Targeting: CDKN1A
CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1
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- Antibody Data
- Antigen structure
- References [1147]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 10355-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10355-1-AP, RRID:AB_2077682
- Product name
- P21 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P21 antibody (Cat. #10355-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression.
X-Box Binding Protein 1 Regulates Osteogenesis of Periodontal Ligament Cells During Aging by Modulating P53 Signaling Pathway.
Comprehensive analysis of mitochondrial unfolded protein response related genes for prognosis and therapeutic response in pancreatic cancer.
Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer.
A promising magnesium-related alloy with metabolic reprogramming and antitumor effects in hepatocellular and pancreatic cancer.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Asiatic Acid Ameliorates MNNG-Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis.
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis.
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification.
Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy.
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.
HIF1A transcriptionally activates CDKN1A to drive ferroptosis in skeletal muscle ischaemia-reperfusion injury.
ETS transcription factor 1-insulin-like growth factor 2 mRNA-binding protein 2-interferon-induced transmembrane protein 3 pathway promotes ferroptosis-driven osteoblast senescence in diabetic osteoporosis.
Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis.
Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles.
The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.
Rejuvenation of THY1(+) nucleus pulposus-derived stem cells promotes intervertebral disc regeneration through FGF10-FGFR1-CREB pathway and mitochondrial fission.
Escitalopram accelerated aging via impaired IIS/autophagy signaling pathway.
Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis.
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma.
APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation.
Alkaloids from Evodia rutaecarpa inhibit the occurrence and development of gallbladder cancer in vivo and in vitro.
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning.
Haizao Yuhu Decoction Inhibits Goiter via p53 Pathway-Induced Apoptosis: Metabolomic and Cellular Assay Analysis.
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration.
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma.
A transcriptome-based tool for assessing skin aging reveals the ameliorative effect of stem cell-derived extracellular vesicles on UVB-induced aging.
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma.
Integrated activity-guided isolation and transcriptomic analysis reveal the therapeutic mechanism of Thonningianin A from Penthhorum chinense Pursh against colorectal cancer via p21 modulation.
Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.
Suppressing the Aberrant Transcriptional Functionality of EWS::FLI1 Oncoprotein by Designer polyQ Fusions with Its Homologous Peptides.
SCHEMBL4796824: a multifaceted antitumor agent targeting microtubule dynamics, DNA damage, and Wnt/β-catenin signaling in ovarian cancer cells.
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.
The prognostic value of miR-323b-5p in non-small cell lung cancer and its mechanism of targeting IL1A in regulating the proliferation and cell cycle of non-small cell lung cancer cells.
3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) is a potential diagnostic and prognostic biomarker in colon adenocarcinoma.
BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53.
Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis.
Engineered microalgae-driven gel platform promotes the repairing of senescence-associated intervertebral disc degeneration in rats and goats.
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy.
Inhibition of the PI3K/AKT signaling pathway blocks the oncogenic activity of TRIM26 in prostate cancer cells.
Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model.
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
Age-associated methionine sulfoxide reductase A protects against valvular interstitial cell senescence and valvular calcification.
Nociceptin-mediated SIRT6 downregulation drives cellular senescence in glioblastoma.
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.
Antioxidant and anti-aging activities of Salvia miltiorrhiza Bunge callus extracts in H(2)O(2)-induced premature senescence and chronological aging models of human dermal fibroblasts.
FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.
UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation.
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Cellular Senescence Drives Zinc Accumulation and Transporter Dysregulation in Intestinal Epithelial Cells.
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.
Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis.
Integrated bioinformatics and experimental validation identify CCDC78 as a prognostic biomarker in colon adenocarcinoma.
Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance.
Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy.
Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression.
Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence.
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
A Biologically Lubricating Allicin-Based Nanoplatform for Remodeling the Inflammation-Senescence Axis in the Treatment of Periodontitis.
3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair.
PLLP inhibits the progression of WT p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59.
Trichosanthes kirilowii extract alleviated liver fibrosis and acute myocardial infarction by inhibiting VCAN to restrain monocyte senescence: Insights from bioinformatic analyses and experimental validation.
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
AnnoNet-TCMs: An annotation network-driven discovery of novel active compounds and mechanisms in traditional Chinese medicine.
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
NLR Risk Score for Predicting Patient Prognosis in Hepatocellular Carcinoma and Identification of Oncogenic Role of NLRP5 in Hepatocellular Carcinoma.
DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy.
PRMT1/PRMT5-Mediated Differential Arginine Methylation of CRIP1 Promotes the Recurrence of Small Cell Lung Cancer after Chemotherapy.
Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling.
Caffeine Alleviates Oxidative Damage of Retinal Pigment Epithelium Cells.
Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.
EIF4A3 Promotes Cell Proliferation via CDC5L Upregulation in Human Breast Cancer Cells.
Overexpression of MCM3 as a prognostic biomarker correlated with cell proliferation, cell cycle and immune regulation in hepatocellular carcinoma.
Capsaicin, the Pungent Component of Red Chili Pepper, induces p21-mediated Cell Cycle Arrest in Renal Cell Carcinoma via Downregulating GLI1: an Experimental Research In Vitro.
Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.
A new SO(2) probe ZSO targeting VDBP inhibits high glucose induced endothelial cell senescence and calcification.
Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models.
3D-cultured hADSCs-derived exosomes deliver circ_0011129 to synergistically attenuate skin photoaging.
METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p.
Dissecting the multi-omics landscape of TEAD1 in hepatocellular carcinoma: cycle regulation and metastatic potential.
Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice.
Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1.
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury.
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.
Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression.
Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD(+) metabolism and promoting IDO2/QPRT expression.
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation.
Identification and validation of the pivotal role of MANF gene in pancreatic β-cell aging using bioinformatics.
Human iPSCs Derived MSCs-Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration.
Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy.
A TP53 Intron-Derived Peptide Promotes Tumor Survival.
Ginsenoside Rh2 ameliorates pulmonary fibrosis via HSP70-dependent autophagic flux regulation and senescence arrest.
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Imbalanced chromatin distribution in cellular senescence specifies paraspeckle dynamics.
Transplanting neural stem cells overexpressing miRNA-21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28-let-7 signaling pathway.
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity.
Canagliflozin improves high-salt-induced aortic arteriosclerosis and premature aging in dahl salt-sensitive rats through the SIRT6/HIF-1 α signaling pathway.
Chemokines and PI3K/AKT signaling pathway mediate the spontaneously ruptured hepatocellular carcinoma through the regulation of the cell cycle.
Dietary Citrate Restores Age-Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis.
Translating m6A-Glycolysis Discovery into Therapy: GOQD-Based Multifunctional Bioactive Scaffolds Rejuvenates Bone Repair in Senescence.
Mesenchymal stem cells and cancer stem cells promote colorectal cancer cell growth and biological functions via cell-cell indirect contact.
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis.
A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC.
SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence.
RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis.
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging.
The long non-coding RNA, CyKILRb, augments oncogenic phenotypes via induction of PIK3R2 and activation of the PI (3) K/AKT axis.
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.
FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA.
Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the IκB/NF-κB pathway to accelerate osteoarthritis.
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Loadless Tendon Explant Model Exhibits Spontaneous Degradative Phenotypes: An In Vitro Study of Human Tendons.
Camptothecin 20(S)-sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade.
Biotransformation of steroid hormones by intestinal fungi and their special cytotoxicity on HeLa cancer cells.
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis.
Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART.
The DNA-PKcs-primary cilia axis maintains ionizing radiation-induced senescence in tumor cells.
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.
Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging.
ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC.
KIF11 variants in familial exudative vitreoretinopathy leading to mTORC1 overactivation and impaired cell cycle progression.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Tau impedes glioma progression by enhancing fatty acid β-oxidation-induced cellular senescence.
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence.
A senescence-responsive nanodrug amplifies radiotherapy efficacy.
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.
USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53.
Design and Synthesis of O-Dialkylaminoalkyl Substituted Urolithin Derivatives: DNA Topoisomerase IIα Inhibition With Promising Antiproliferative Activity.
TFDP1 drives triple-negative breast Cancer development through senescence suppression and serves as a therapeutic target for topotecan.
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Knockdown of C3aR alleviates age-related bone loss via activation of YAP1/β-catenin signaling.
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6.
Expression, characterization and anti-colon cancer activity of recombinant ginseng peptides with amino acid tandem repeats.
Resveratrol Promotes Wound Healing by Enhancing Angiogenesis via Inhibition of Ferroptosis.
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways.
Modulation of senescent Lepr(+) skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression.
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells.
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.
Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels.
GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement.
Ginsenoside CK and retinol on UVA-induced photoaging exert the synergistic effect through antioxidant and antiapoptotic mechanisms.
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Phase separation of MRG15 delays cellular senescence.
Investigating the role of IL-6 in the pathogenesis of systemic lupus erythematosus: Insights from bone marrow mesenchymal stem cells.
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
Astragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated m(6)A methylation.
AP2A1 modulates cell states between senescence and rejuvenation.
Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy.
Targeting senescence in Amyotrophic Lateral Sclerosis: senolytic treatment improves neuromuscular function and preserves cortical excitability in a TDP-43(Q331K) mouse model.
Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality.
Multi-Water Bridges Enable Design of BET BD1-Selective Inhibitors for Pancreatic Cancer Therapy.
Metformin-Loaded Tannic Acid Nanoparticles Attenuate Osteoarthritis by Promoting Chondrocyte Mitochondria Homeostasis Based on Mitocytosis.
Tasquinimod promotes the sensitivity of ovarian cancer cells to cisplatin by down-regulating the HDAC4/p21 pathway.
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells.
Rictor orchestrates β-catenin/FOXO balance by maintaining redox homeostasis during development of ovarian cancer.
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Fe-curcumin nanozymes-mediated reactive oxygen species scavenging and anti-apoptotic effects on age-related cataracts.
A multifunctional parathyroid hormone-related supramolecular peptide-loaded dual network hydrogel for radiation-induced wound repair.
Doxorubicin-induced senescence is modulated by the eukaryotic release factor 3a and its polyglycine expansion in HCT116 cells.
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
20(S)-ginsenoside Rg3 suppresses gastric cancer cell proliferation by inhibiting E2F-DP dimerization.
Mai-wei-yang-fei decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation.
EFNA1 promotes the tumorigenesis and metastasis of cervical cancer by phosphorylation pathway and epithelial-mesenchymal transition.
Effect of COL11A1 on oral squamous cell carcinoma.
Charting the regulatory landscape of TP53 on transposable elements in cancer.
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice.
Study on the role of miR-10b-3p as SASP in exosomes of premature senescent hepatocytes induced by hexavalent chromium.
HNF4A promotes tumor progression in gastric cancer by transcriptional activation of KIF2C.
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
Mechanistic Insights Into 5'-tiRNA-His-GTG Mediated Activation of the JNK Pathway in Skin Photoaging.
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury.
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H.
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Injectable thermosensitive hydrogel-encapsulated paclitaxel liposomes enriched with miR-455-3p antagomir for dormancy therapy of salivary adenoid cystic carcinoma.
C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging.
Integrating Multiomics and Machine Learning: Senescence-Regulated ALMS1-IT1/miR-7c-5p/HMGA2 Axis as a Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma.
Exploring ID4 as a driver of aggression and a therapeutic target in triple-negative breast cancer.
E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.
MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway.
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7.
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Shanyao regulates the PI3K/AKT/P21 pathway to promote oogonial stem cell proliferation and stemness restoration to alleviate premature ovarian insufficiency.
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.
Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes.
Nitazoxanide alleviates experimental pulmonary fibrosis by inhibiting the development of cellular senescence.
DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway.
The H5N1-NS1 protein affects the host cell cycle and apoptosis through interaction with the host lncRNA PIK3CD-AS2.
Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD(+) acute myeloid leukemia.
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Reduced OTUD7B expression correlates with poor prognosis in PTCL via non-canonical NF-κB.
Senescent Fibroblasts Drive FAP/OLN Imbalance Through mTOR Signaling to Exacerbate Inflammation and Bone Resorption in Periodontitis.
CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy.
PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53.
Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles.
Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.
Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
UFMylation maintains YAP stability to promote vascular endothelial cell senescence.
Luteolin Mitigates Photoaging Caused by UVA-Induced Fibroblast Senescence by Modulating Oxidative Stress Pathways.
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
Injectable DAT-ALG Hydrogel Mitigates Senescence of Loaded DPMSCs and Boosts Healing of Perianal Fistulas in Crohn's Disease.
3D-cultured DFAT spheroid-derived exosomes promote aged wound healing via modulation of the NF-κB/Serpine1 pathway.
Identification of GBP6 as a potential prognostic biomarker in esophageal carcinoma by integrated bioinformatics analysis and experiment validation.
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice.
Fluorescence lifetime clocks quantify senescence and aging.
Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling.
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging.
Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal Keratinocyte-Like Cell Population and Defective Epidermal Stratification.
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
EXOSC3 knockdown induces G1/S phase arrest to suppress hepatocellular carcinoma cell proliferation.
ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms.
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells.
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth.
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy.
CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation.
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
CD81(+) senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.
Overexpression of FOS enhances the malignant potential of eutopic endometrial stromal cells in patients with endometriosis‑associated ovarian cancer.
Integrative analysis of genetic variability and functional traits in lung adenocarcinoma epithelial cells via single-cell RNA sequencing, GWAS, bayesian deconvolution, and machine learning.
Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma.
Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging.
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice.
Development and Validation of a Prognostic Model for Lung Adenocarcinoma Based on CAF-Related Genes: Unveiling the Role of COX6A1 in Cancer Progression and CAF Infiltration.
Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma.
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug.
Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice.
PRC1 promotes ovarian cancer progression by binding to RPL4 and increasing MDM2-mediated p53 ubiquitination.
Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease.
Conditional Overexpression of Neuritin in Supporting Cell Protects Cochlear Hair Cell and Delays Age-Related Hearing Loss by Enhancing Autophagy.
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Inhibition of AGTR1 attenuates cell proliferation after glaucoma filtration surgery via NF-κB pathway-mediated G(0)/G(1)-phase cell cycle arrest.
BANP Participates in the Chronic Intermittent Hypoxia-Induced Senescence of Vascular Endothelial Cells by Promoting P53 Phosphorylation and Nuclear Retention.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB.
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System.
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Ursolic Acid Alleviates Mitotic Catastrophe in Podocyte by Inhibiting Autophagic P62 Accumulation in Diabetic Nephropathy.
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
CENPW knockdown inhibits progression of bladder cancer through inducing cell cycle arrest and apoptosis.
IPCEF1: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma.
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence.
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
MDM2 inhibitor APG-115 synergizes with ABT-199 to induce cell apoptosis in chronic lymphocytic leukemia.
Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence.
14-3-3σ/Stratifin and p21 limit AKT-related malignant progression in skin carcinogenesis following MDM2-associated p53 loss.
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.
Ubiquitination of p21 by E3 ligase RNF135 promotes the proliferation of human glioblastoma cells.
Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p/CDK2AP2 axis in non-small cell lung cancer.
Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1).
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Mitochondrial dysfunction-associated alveolar epithelial senescence is involved in CdCl(2)-induced COPD-like lung injury.
YIPF2 regulates genome integrity.
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.
Asparagine Dependency Is a Targetable Metabolic Vulnerability in TP53-Altered Castration-Resistant Prostate Cancer.
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries.
Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K-AKT and apoptosis pathways.
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress.
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Cdk1/p53/p21 feedback loop mechanisms in the pathogenesis of interstitial cystitis/bladder pain syndrome.
Hsa-miR-3928-3p targets the CCL3/CCR5 axis to induce amniotic epithelial cell senescence involved in labor initiation.
SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling.
Identification and biological evaluation of fused tetrahydroisoquinoline derivatives as Wnt/β-catenin signaling inhibitors to suppress colorectal cancer.
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Zuogui Pills alleviate cyclophosphamide-induced ovarian aging by reducing oxidative stress and restoring the stemness of oogonial stem cells through the Nrf2/HO-1 signaling pathway.
Characterization of PANoptosis-related genes with immunoregulatory features in osteoarthritis.
Sulforaphane Promotes Proliferation of Porcine Granulosa Cells via the H3K27ac-Mediated GDF8-ALK5-ERK Pathway.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy.
SIRT1-mediated tunnelling nanotubes may be a potential intervention target for arsenic-induced hepatocyte senescence and liver damage.
Discovery of Potent Covalent CRM1 Inhibitors Via a Customized Structure-Based Virtual Screening Pipeline and Bioassays.
Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells.
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 Inflammasome.
Leptin promotes tendon stem/progenitor cell senescence through the AKT-mTOR signaling pathway.
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.
Naringin Induces ROS-Stimulated G(1) Cell-Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Cells.
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis.
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway.
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3.
PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging.
Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress.
A single-cell transcriptomic census of mammalian olfactory epithelium aging.
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Vitamin C ameliorates D-galactose-induced senescence in HEI-OC1 cells by inhibiting the ROS/NF-κB pathway.
LINC00470 promotes malignant progression of testicular germ cell tumors.
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis.
SIRT6-mediated vascular smooth muscle cells senescence participates in the pathogenesis of abdominal aortic aneurysm.
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation.
Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2.
An integrated multi-omics analysis reveals osteokines involved in global regulation.
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
ABI3BP promotes renal aging through Klotho-mediated ferroptosis.
Pectinose induces cell cycle arrest in luminal A and triple-negative breast cancer cells by promoting autophagy through activation of the p38 MAPK signaling pathway.
SVHRSP Alleviates Age-Related Cognitive Deficiency by Reducing Oxidative Stress and Neuroinflammation.
D-arabinose induces cell cycle arrest by promoting autophagy via p38 MAPK signaling pathway in breast cancer.
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis.
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping.
Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia.
Mechanisms of PM(10) Disruption of the Nrf2 Pathway in Cornea.
Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation.
Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia.
DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma.
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis.
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.
Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia.
Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy.
Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade.
MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer.
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.
Deoxynivalenol induces m(6)A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro.
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis.
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium.
The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress.
The molecular mechanism of action for the potent antitumor component extracted using supercritical fluid extraction from Croton crassifolius root.
Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway.
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy.
Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid.
Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy.
Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1-STING axis.
Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis.
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
METTL1-modulated LSM14A facilitates proliferation and migration in glioblastoma via the stabilization of DDX5.
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution.
Bavachinin protects the liver in NAFLD by promoting regeneration via targeting PCNA.
Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.
High glucose levels delay the senescence of stem cells from human exfoliated deciduous teeth by suppressing autophagy.
Epiberberine induced p53/p21-dependent G2/M cell cycle arrest and cell apoptosis in gastric cancer cells by activating γ-aminobutyric acid receptor- β3.
Cellular and molecular mechanisms of highly active mesenchymal stem cells in the treatment of senescence of rhesus monkey ovary.
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL.
Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
Mitophagy-Mediated Tumor Dormancy Protects Cancer Cells from Chemotherapy.
Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.
Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G(2)/M phase arrest via PI3K/AKT signaling pathway.
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway.
Silencing geranylgeranyltransferase I inhibits the migration and invasion of salivary adenoid cystic carcinoma through RhoA/ROCK1/MLC signaling and suppresses proliferation through cell cycle regulation.
Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence.
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells.
Prognosis and biological function of SGOL1 in clear cell renal cell carcinoma: a multiomics analysis.
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress.
ROS-Induced Gingival Fibroblast Senescence: Implications in Exacerbating Inflammatory Responses in Periodontal Disease.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
H(2)Se-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence.
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
Single-cell transcriptomic atlas of taste papilla aging.
PiRNA CFAPIR inhibits cardiac fibrosis by regulating the muscleblind-like protein MBNL2.
Rosmarinic acid attenuates glioblastoma cells and spheroids' growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis.
Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.
Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients.
RBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma.
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway.
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Mitochondrial copper overload promotes renal fibrosis via inhibiting pyruvate dehydrogenase activity.
Design and Discovery of New Collagen V-Derived FGF2-Blocking Natural Peptides Inhibiting Lung Squamous Cell Carcinoma In Vitro and In Vivo.
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells.
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
The role of BUD31 in clear cell renal cell carcinoma: prognostic significance, alternative splicing, and tumor immune environment.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms.
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Sciellin promotes the development and progression of thyroid cancer through the JAK2/STAT3 signaling pathway.
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging.
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome.
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells.
The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component.
Chronic low-dose deltamethrin exposure induces colon injury and aggravates DSS-induced colitis via promoting cellular senescence.
Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.
Effects of Ginsenoside Rg1 on the Biological Behavior of Human Amnion-Derived Mesenchymal Stem/Stromal Cells (hAD-MSCs).
IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway.
SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation.
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
The cancer/testis antigen HORMAD1 promotes gastric cancer progression by activating the NF-κB signaling pathway and inducing epithelial-mesenchymal transition.
SHCBP1 Promotes the Proliferation of Breast Cancer Cells by Inhibiting CXCL2.
Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets.
Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway.
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Fanconi anemia pathway regulation by FANCI in prostate cancer.
PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer.
Triptolide inhibits the progression of Glioblastoma U251 cells via targeting PROX1.
Bazi Bushen alleviates skin senescence by orchestrating skin homeostasis in SAMP6 mice.
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2.
Fangchinoline derivatives inhibits PI3K signaling in vitro and in vivo in non-small cell lung cancer.
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Silencing of LINC00467 inhibits cell proliferation in testicular germ cell tumors cells.
miR-491-5p regulates the susceptibility of glioblastoma to ferroptosis through TP53.
Multi-omic analysis of mandibuloacral dysplasia type A patient iPSC-derived MSC senescence reveals miR-311 as a novel biomarker for MSC senescence.
Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.
Elabela inhibits TRAF1/NF-κB induced oxidative DNA damage to promote diabetic foot ulcer wound healing.
Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE-Choroid.
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation.
Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells.
PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts.
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.
The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma.
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Umbilical Cord Mesenchymal-Stem-Cell-Derived Exosomes Exhibit Anti-Oxidant and Antiviral Effects as Cell-Free Therapies.
Inhibition of autophagy can promote the apoptosis of bladder cancer cells induced by SC66 through the endoplasmic reticulum stress pathway.
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer.
Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway.
TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.
Hydrogen sulfide inhibits the rupture of fetal membranes throngh anti-aging pathways.
IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A.
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.
Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation.
Micronano Titanium Accelerates Mesenchymal Stem Cells Aging through the Activation of Senescence-Associated Secretory Phenotype.
Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability.
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Hydrogen sulfide ameliorates endothelial dysfunction in aging arteries by regulating ferroptosis.
N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21(cip1/waf1)/CDK2-Cyclin E1 axis-mediated cell cycle transition.
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
Angelicin impedes the progression of glioblastoma via inactivation of YAP signaling pathway.
Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53.
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
The Males Absent on the First (MOF) Mediated Acetylation Alters the Protein Stability and Transcriptional Activity of YY1 in HCT116 Cells.
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors.
A Comprehensive Analysis Revealing FBXW9 as a Potential Prognostic and Immunological Biomarker in Breast Cancer.
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells.
EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.
Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition.
SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.
TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.
Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells.
The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex.
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Oridonin impedes breast cancer growth by blocking cells in S phase and inhibiting the PI3K/AKT/mTOR signaling pathway.
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
SELENOF Controls Proliferation and Cell Death in Breast-Derived Immortalized and Cancer Cells.
Cold exposure protects against medial arterial calcification development via autophagy.
Treatment of advanced atherosclerotic mice with the senolytic agent ABT-263 is associated with reduced indices of plaque stability and increased mortality.
RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2).
Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.
Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis.
saKLK1-374 is more difficult to induce KLK1 expression in normal prostate cell lines than that in prostate cancer cell lines: Rethinking the universality of RNA activation.
Particle Debris Generated from Passenger Tires Induces Morphological and Gene Expression Alterations in the Macrophages Cell Line RAW 264.7.
Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.
MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6.
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Chidamide Induces Epstein-Barr Virus (EBV) Lytic Infection and Acts Synergistically with Tenofovir to Eliminate EBV-Positive Burkitt Lymphoma.
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Exogenous H(2)S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice.
HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency.
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis.
Lnc-PKNOX1-1 inhibits tumor progression in cutaneous malignant melanoma by regulating NF-κB/IL-8 axis.
Cellular senescence contributes to mechanical ventilation-induced diaphragm dysfunction by upregulating p53 signalling pathways.
Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration.
Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes.
The MAD2B-APC/C-MDM2 axis mediates acute kidney injury by modulating p53.
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.
PNU-74654 Induces Cell Cycle Arrest and Inhibits EMT Progression in Pancreatic Cancer.
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Low-dose graphene oxide promotes tumor cells proliferation by activating PI3K-AKT-mTOR signaling via cellular membrane protein integrin αV.
TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle.
Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.
The flavonoid GL-V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells.
Delivery of miR-3529-3p using MnO(2) -SiO(2) -APTES nanoparticles combined with phototherapy suppresses lung adenocarcinoma progression by targeting HIGD1A.
Long non-coding RNA DINO promotes cisplatin sensitivity in lung adenocarcinoma via the p53-Bax axis.
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma.
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Promotion of Cervical Cancer Cell Proliferation by miR-130b Expression Level Changes and Inhibition of its Apoptosis by Targeting CDKN1A Gene.
MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B.
KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis.
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy.
FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A.
Rg1 Protects Hematopoietic Stem Cells from LiCl-Induced Oxidative Stress via Wnt Signaling Pathway.
SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis.
Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.
1,25(OH)(2)D(3) Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway.
Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification.
HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle.
Aldolase A promotes cell proliferation and cisplatin resistance via the EGFR pathway in gastric cancer.
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways.
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1.
Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.
Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration.
Oridonin Delays Aging Through the AKT Signaling Pathway.
Chrysin Ameliorates Influenza Virus Infection in the Upper Airways by Repressing Virus-Induced Cell Cycle Arrest and Mitochondria-Dependent Apoptosis.
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway.
Identification and Validation of Ferroptosis-Related Biomarkers in Septic Cardiomyopathy via Bioinformatics Analysis.
Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging.
Investigation of the inhibition effect of 1,2,3,4,6-pentagalloyl-β-D-glucose on gastric cancer cells based on a network pharmacology approach and experimental validation.
Knockdown of LMNB1 Inhibits the Proliferation of Lung Adenocarcinoma Cells by Inducing DNA Damage and Cell Senescence.
Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma.
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice.
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.
PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.
Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure.
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Tetrahydroxy stilbene glucoside alters neurogenesis and neuroinflammation to ameliorate radiation-associated cognitive disability via AMPK/Tet2.
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism.
Bisphenol A exposure causes testicular toxicity by targeting DPY30-mediated post-translational modification of PI3K/AKT signaling in mice.
Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence.
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
In vitro and in vivo effects of hyperglycemia and diabetes mellitus on nucleus pulposus cell senescence.
Circadian clock gene BMAL1 inhibits the proliferation and tumor-formation ability of nasopharyngeal carcinoma cells and increases the sensitivity of radiotherapy.
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.
The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
NOP53 undergoes liquid-liquid phase separation and promotes tumor radio-resistance.
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability.
RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway.
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux.
Astragaloside IV alleviates senescence of vascular smooth muscle cells through activating Parkin-mediated mitophagy.
Identification of 3-Phenylquinoline Derivative PQ1 as an Antagonist of p53 Transcriptional Activity.
Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells.
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network.
Dictamnine inhibits pancreatic cancer cell growth and epithelial-mesenchymal transition by blocking the PI3K/AKT signaling pathway.
Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster.
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma.
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Identification and validation of aging-related genes in COPD based on bioinformatics analysis.
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer.
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.
MiR-205-5p promotes lung cancer progression and is valuable for the diagnosis of lung cancer.
TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer.
Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization.
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells.
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence.
The serum soluble Klotho alleviates cardiac aging and regulates M2a/M2c macrophage polarization via inhibiting TLR4/Myd88/NF-κB pathway.
Comparative analysis of mouse embryonic palatal mesenchymal cells isolated by two primary culture methods.
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary.
DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H(2)S in Diabetes.
Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis.
Downregulation of HINFP induces senescence-associated secretory phenotype to promote metastasis in a non-cell-autonomous manner in bladder cancer.
High expression of 14-3-3ơ indicates poor prognosis and progression of lung adenocarcinoma.
Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis.
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality.
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling.
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy.
Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion-Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
CHMFL-BMX-078, a BMX inhibitor, overcomes the resistance of melanoma to vemurafenib via inhibiting AKT pathway.
The Role of RAD6B and PEDF in Retinal Degeneration.
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Heterozygous FMN2 missense variant found in a family case of premature ovarian insufficiency.
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells.
Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis.
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
Tetrahydroxy stilbene glycoside attenuates endothelial cell premature senescence induced by H(2)O(2) through the microRNA-34a/SIRT1 pathway.
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions.
lncRNA NEAT1-let 7b-P21 axis mediates the proliferation of neural stem cells cultured in vitro promoted by radial extracorporeal shock wave.
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Exogenous hydrogen sulfide inhibits the senescence of cardiomyocytes through modulating mitophagy in rats.
Canine Mammary Tumor Cell Lines Derived from Metastatic Foci Show Increased RAD51 Expression but Diminished Radioresistance via p21 Inhibition.
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.
l-Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein-Barr virus-positive Burkitt lymphoma.
Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy.
Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide.
Long noncoding RNA HOXC-AS3 interacts with CDK2 to promote proliferation in hepatocellular carcinoma.
Alteration of E2F2 Expression in Governing Endothelial Cell Senescence.
Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.
HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC.
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity.
Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma.
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors.
DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation.
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
PRRSV Promotes MARC-145 Cells Entry Into S Phase of the Cell Cycle to Facilitate Viral Replication via Degradation of p21 by nsp11.
Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion.
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells.
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
Loss of DAB2IP Contributes to Cell Proliferation and Cisplatin Resistance in Gastric Cancer.
Inhibition of mu-opioid receptor suppresses proliferation of hepatocellular carcinoma cells via CD147-p53-MAPK cascade signaling pathway.
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation.
N6-methyladenosine regulates ATM expression and downstream signaling.
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.
Identifying the Key Genes in Mouse Liver Regeneration After Partial Hepatectomy by Bioinformatics Analysis and in vitro/vivo Experiments.
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21(Cip1/WAF1).
Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
Long Non-Coding RNA CCAT2 Activates RAB14 and Acts as an Oncogene in Colorectal Cancer.
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis.
SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway.
The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.
PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma.
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.
Kojic acid enhances the proliferation of human corneal epithelial cells via p38 and p21 signaling pathways.
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas.
RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis.
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
LncRNA ENSG00000254615 Modulates Proliferation and 5-FU Resistance by Regulating p21 and Cyclin D1 in Colorectal Cancer.
A novel histone deacetylase inhibitor LT-548-133-1 induces apoptosis by inhibiting HDAC and interfering with microtubule assembly in MCF-7 cells.
Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells.
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
A novel mutation in PCK2 gene causes primary angle-closure glaucoma.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells.
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
NEDD4L-induced ubiquitination mediating UBE2T degradation inhibits progression of lung adenocarcinoma via PI3K-AKT signaling.
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis.
Mitomycin induces alveolar epithelial cell senescence by down-regulating GSK3β signaling.
The whole profiling and competing endogenous RNA network analyses of noncoding RNAs in adipose-derived stem cells from diabetic, old, and young patients.
LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
Activity Components from Gynostemma pentaphyllum for Preventing Hepatic Fibrosis and of Its Molecular Targets by Network Pharmacology Approach.
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.
Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p.
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Two loss-of-function ANKRD11 variants in Chinese patients with short stature and a possible molecular pathway.
SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Morphologic Analysis of Urinary Podocytes in Focal Segmental Glomerulosclerosis.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells.
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
The SESAME complex regulates cell senescence through the generation of acetyl-CoA.
METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer.
Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation.
Regulatory effect of microRNA-223-3p on breast cancer cell processes via the Hippo/Yap signaling pathway.
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Chemopreventive effects of pterostilbene through p53 and cell cycle in mouse lung of squamous cell carcinoma model.
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.
Suppression of TCAB1 expression induced cellular senescence by lessening proteasomal degradation of p21 in cancer cells.
Premature senescence of placental decidua cells as a possible cause of miscarriage produced by mycophenolic acid.
The Interaction of the Senescent and Adjacent Breast Cancer Cells Promotes the Metastasis of Heterogeneous Breast Cancer Cells through Notch Signaling.
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Ubiquitination of p21 by E3 Ligase TRIM21 Promotes the Proliferation of Human Neuroblastoma Cells.
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Fumonisin B(1) Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells.
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway.
PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer.
Dlx5 promotes cancer progression through regulation of CCND1 in oral squamous cell carcinoma (OSCC).
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Identification and characterization of R2TP in the development of oral squamous cell carcinoma.
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib.
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6.
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer.
Safrana l Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2.
THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways.
Enhanced Effect of IL-1β-Activated Adipose-Derived MSCs (ADMSCs) on Repair of Intestinal Ischemia-Reperfusion Injury via COX-2-PGE(2) Signaling.
Skp2 modulates proliferation, senescence and tumorigenesis of glioma.
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells.
Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma.
NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.
Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS.
E2F7, regulated by miR‑30c, inhibits apoptosis and promotes cell cycle of prostate cancer cells.
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.
Paris polyphylla ethanol extract induces G2/M arrest and suppresses migration and invasion in bladder cancer.
Azidothymidine (AZT) Inhibits Proliferation of Human Ovarian Cancer Cells by Regulating Cell Cycle Progression.
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
KIF15 contributes to cell proliferation and migration in breast cancer.
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells.
SLC25A10 performs an oncogenic role in human osteosarcoma.
Minichromosome maintenance protein 5 is an important pathogenic factor of oral squamous cell carcinoma.
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Loss of RAD6B induces degeneration of the cochlea in mice.
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Epidermal ROCK2 induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma.
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.
Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
A translational program that suppresses metabolism to shield the genome.
Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit.
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways.
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.
SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression.
Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.
Identification of apoptosis-associated protein factors distinctly expressed in cigarette smoke condensate-exposed airway bronchial epithelial cells.
Decreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail‑induced epithelial‑mesenchymal transition.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma.
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
LINC00511 contributes to glioblastoma tumorigenesis and epithelial-mesenchymal transition via LINC00511/miR-524-5p/YB1/ZEB1 positive feedback loop.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways.
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.
miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5.
CARLo-5 as an oncogenic gene in endometrial carcinoma.
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
Qingjie Fuzheng Granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via Sonic Hedgehog pathway.
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Postprandial triglyceride-rich lipoproteins-induced premature senescence of adipose-derived mesenchymal stem cells via the SIRT1/p53/Ac-p53/p21 axis through oxidative mechanism.
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation.
Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.
Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways.
Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro.
Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma.
Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway.
A combination of low-dose decitabine and chidamide resulted in synergistic effects on the proliferation and apoptosis of human myeloid leukemia cell lines.
HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer.
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression.
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging.
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner.
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.
RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer.
Conditioned medium derived from human amniotic stem cells delays H2O2‑induced premature senescence in human dermal fibroblasts.
Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.
Self-Assembled saRNA Delivery System Based on Rolling Circle Transcription for Aptamer-Targeting Cancer Therapy.
Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.
Upregulation of lncRNA DGCR5 correlates with better prognosis and inhibits bladder cancer progression via transcriptionally facilitating P21 expression.
NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway.
Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract.
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride.
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
Three kinds of corneal host cells contribute differently to corneal neovascularization.
Potent and specific MTH1 inhibitors targeting gastric cancer.
miR-384-5p Targets Gli2 and Negatively Regulates Age-Related Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells.
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Effect of ingredients from Chinese herbs on enterovirus D68 production.
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
CircCDYL inhibits the expression of C-MYC to suppress cell growth and migration in bladder cancer.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer.
Bone secreted factors induce cellular quiescence in prostate cancer cells.
Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.
Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21(Waf1/Cip1).
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer.
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin.
Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma.
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy.
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcoma.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.
[Infiltrating mast cells promote neuroendocrine differentiation and increase docetaxel resistance of prostate cancer cells by up-regulating p21].
Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention.
Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression.
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.
A pH probe inhibits senescence in mesenchymal stem cells.
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells.
Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Suppressed epithelial-mesenchymal transition and cancer stem cell properties mediate the anti-cancer effects of ethyl pyruvate via regulation of the AKT/nuclear factor-κB pathway in prostate cancer cells.
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A.
Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Histone deacetylase inhibitor NaBut suppresses cell proliferation and induces apoptosis by targeting p21 in multiple myeloma.
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
H(2)S Donor NaHS Changes the Production of Endogenous H(2)S and NO in D-Galactose-Induced Accelerated Ageing.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms.
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest.
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
TRPC5 channel modulates endothelial cells senescence.
Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression.
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Cigarette smoke extract-induced proliferation of normal human urothelial cells via the MAPK/AP-1 pathway.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence.
ISG15 inhibits cancer cell growth and promotes apoptosis.
Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21, P27 and p38MAPK/MMP-9.
Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells.
Berberine enhances the anti‑tumor activity of tamoxifen in drug‑sensitive MCF‑7 and drug‑resistant MCF‑7/TAM cells.
Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival.
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma.
Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression.
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.
Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress.
The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker.
Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Macrophage migration inhibitory factor in the regulation of myoblast proliferation and differentiation.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats.
A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells.
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
MiR-512-5p induces apoptosis and inhibits glycolysis by targeting p21 in non-small cell lung cancer cells.
miRNA-149* promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia.
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21(Waf1/Cip1) and p27(Kip1).
Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells.
A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line.
Study on the Dynamic Biological Characteristics of Sca-1(+) Hematopoietic Stem and Progenitor Cell Senescence.
Induction of Apoptosis in Human Leukemic Cell Lines by Diallyl Disulfide via Modulation of EGFR/ERK/PKM2 Signaling Pathways.
Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549.
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.
Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.
MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
FXR induces SOCS3 and suppresses hepatocellular carcinoma.
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.
MKL1 inhibits cell cycle progression through p21 in podocytes.
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy.
Potent effects of dioscin against liver fibrosis.
Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects.
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
The involvement of CXCR7 in modulating the progression of papillary thyroid carcinoma.
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Association of p53/p21 expression and cigarette smoking with tumor progression and poor prognosis in non-small cell lung cancer patients.
Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma.
miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA.
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expression in SMMC-7721 hepatocellular carcinoma cells.
Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis.
Long M, Chen Y, Du R, Yang J, Wang J, Sun Y, Tian X, Wang S, Zhong Y, Liang W, Zhang J, Shang Z
International journal of biological sciences 2026;22(3):1186-1206
International journal of biological sciences 2026;22(3):1186-1206
X-Box Binding Protein 1 Regulates Osteogenesis of Periodontal Ligament Cells During Aging by Modulating P53 Signaling Pathway.
Zheng Y, Zhai M, Bai X, Yu K, Li J, Zhang Z
Stem cells international 2026;2026:2846096
Stem cells international 2026;2026:2846096
Comprehensive analysis of mitochondrial unfolded protein response related genes for prognosis and therapeutic response in pancreatic cancer.
Li C, Lu C, Ma Z, Zhao T, Xiao M, Xu Z, Sun Z, Wu Q, Wang L, Zhao L
Frontiers in immunology 2026;17:1717925
Frontiers in immunology 2026;17:1717925
Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer.
Kuang Y, Jia M, Zhu Y, Xiang Z
PeerJ 2026;14:e20476
PeerJ 2026;14:e20476
A promising magnesium-related alloy with metabolic reprogramming and antitumor effects in hepatocellular and pancreatic cancer.
Zhang J, Gu J, Xia R, Yin J, Wang X, Yang J, Wang Y, Yi Z, Wang S, Zhang Q, Wang H, She J, Guo S
Bioactive materials 2026 May;59:186-204
Bioactive materials 2026 May;59:186-204
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Asiatic Acid Ameliorates MNNG-Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis.
Zhou F, Zhu C, Yuan W, Peng W, Xu Q, Yang H, Cao R, Wang B, Wang M, Xu H
Phytotherapy research : PTR 2026 May;40(5):2210-2229
Phytotherapy research : PTR 2026 May;40(5):2210-2229
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis.
Pan J, Zhang Z, Ma Y, Gao Y, Wang Z, Ma J, Wang X
Ecotoxicology and environmental safety 2026 May;316:120177
Ecotoxicology and environmental safety 2026 May;316:120177
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification.
Zhang Y, Dong X, Yan X, Zhao C, Chi X, Zhao B, Miao J, Hong F, Lin Z
Redox biology 2026 Mar;90:104058
Redox biology 2026 Mar;90:104058
Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy.
Rullo A, Flowers B, Chang K, Zhang A, Petukhova VZ, Harding L, Aboagye SY, Bocchetta M, Qiu W, Williams DL, Angelucci F, Petukhov PA, Kastrati I
Redox biology 2026 Mar;90:103980
Redox biology 2026 Mar;90:103980
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Zhuang Z, Han C, Cai M, Li M, Lin S, Chen L, Zhu Z, Zhang H, Xing C, Han B, Yang R
Journal of advanced research 2026 Mar;81:349-364
Journal of advanced research 2026 Mar;81:349-364
Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.
Zhu L, Tang Z, Hu R, Li Y, Li X, Gu M, Yang Y
Journal of periodontal research 2026 Mar;61(3):292-308
Journal of periodontal research 2026 Mar;61(3):292-308
HIF1A transcriptionally activates CDKN1A to drive ferroptosis in skeletal muscle ischaemia-reperfusion injury.
Zhou M, Wang K, Jin Y, Liu J, Xue Y, Wang Y, Jia X, Liu H, Wang P, Li Z, Pan X, Ma Y, Rui Y
Journal of orthopaedic translation 2026 Mar;57:101055
Journal of orthopaedic translation 2026 Mar;57:101055
ETS transcription factor 1-insulin-like growth factor 2 mRNA-binding protein 2-interferon-induced transmembrane protein 3 pathway promotes ferroptosis-driven osteoblast senescence in diabetic osteoporosis.
Liu XW, Zhang SB, Xu HW, Lu JH, Chang SJ, Huang SS, Wang SJ
International journal of biological macromolecules 2026 Mar;350:150917
International journal of biological macromolecules 2026 Mar;350:150917
Magnesium Deficiency Accelerates Gut Aging and Increases Susceptibility to Colitis.
Zhang R, Ge M, Hu M, Zhao Y, Chong B, Li W, Yu J, Lu Y, He S, Wang J, Yue J, Chen HN, Xu H, Peng Y, Lei P, Liu Z, Dai L
Aging cell 2026 Mar;25(3):e70446
Aging cell 2026 Mar;25(3):e70446
Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles.
Ma T, Bao H, Xu Z, Ren H, Tian W, Chen J, Liu Z, Lu X, Lv F, Yao Q, Qi Y, Huang K
Aging cell 2026 Mar;25(3):e70443
Aging cell 2026 Mar;25(3):e70443
The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.
Mao K, Zhu W, Sun H, Zheng H, Fu Z
Cellular signalling 2026 Mar;139:112342
Cellular signalling 2026 Mar;139:112342
Rejuvenation of THY1(+) nucleus pulposus-derived stem cells promotes intervertebral disc regeneration through FGF10-FGFR1-CREB pathway and mitochondrial fission.
Zhai H, Wang Z, Wang S, Liu Z, Zhao D, Zhang Y, Liu K, Kong X, Meng Q, Gu H, Chen L, Zhang Y, Cheng L
Journal of advanced research 2026 Mar 9;
Journal of advanced research 2026 Mar 9;
Escitalopram accelerated aging via impaired IIS/autophagy signaling pathway.
Chen ZY, Qi CY, Feng J, Xue K, Quan HB, Zhou J, Liu WZ, Lu GD
GeroScience 2026 Mar 5;
GeroScience 2026 Mar 5;
Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.
Xiao G, Annor GK, Harmon KW, Chavez V, Levine F, Ahuno S, Atmane MI, St Jean S, Rowdo FPM, Leybengrub P, Gaglio A, Ellison V, Venkatesh D, Sun S, Merghoub T, Greenbaum B, Elemento O, Davis MB, Ogunwobi O, Bargonetti J
bioRxiv : the preprint server for biology 2026 Mar 28;
bioRxiv : the preprint server for biology 2026 Mar 28;
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis.
Zou L, Ma Y, Hu M, Sun Z, Shi Z, Gao J, Cai X
Journal of bioenergetics and biomembranes 2026 Mar 26;58(1)
Journal of bioenergetics and biomembranes 2026 Mar 26;58(1)
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Qin W, Wei J, Li F, Wang L, Zhang Q, Chen J, Lu P, Long T, Liu A, Cao J, Deng Y, Zhang H, Chen D, Cui J, Zhao W
Cell reports 2026 Mar 24;45(3):116993
Cell reports 2026 Mar 24;45(3):116993
CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma.
Cao Y, Xu C, Liu Y, Shi B, Li X, Li J, Zhang B, Zhang Z, Dai S, Sun Q, Gu J
iScience 2026 Mar 20;29(3):114840
iScience 2026 Mar 20;29(3):114840
APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
Zhang C, Cao S, Zeng G, Dong Y, Li H, Ma X, Zhang X, Li Z, Huang Y
Scientific reports 2026 Mar 15;16(1)
Scientific reports 2026 Mar 15;16(1)
Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation.
Liu J, Duan Y, Xiao Q, Deng S, Li A, Wu D, Wu J, Liu C, Yi H, Wang M, Shu G, Yin G
Cell death and differentiation 2026 Mar 14;
Cell death and differentiation 2026 Mar 14;
Alkaloids from Evodia rutaecarpa inhibit the occurrence and development of gallbladder cancer in vivo and in vitro.
Li Y, Zhou S, Xu H, Zhou H, Sun K, Hu S, Xu K, Yang J, Chen Y, Li W
Scientific reports 2026 Mar 13;16(1)
Scientific reports 2026 Mar 13;16(1)
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Chen J, Xue M, Mi S, Fu A, Chen W, Sun Y, Xia S, Ge Q, Luo J, Yu Q, Wang L, Chen S
Nature communications 2026 Mar 1;17(1)
Nature communications 2026 Mar 1;17(1)
Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning.
Qiu B, Chen T, Hong Q, Xie X, Xue M, Xu N, Shi C, Xu G, Wang W, Sulaiman M, Xi Y
Biochemistry and biophysics reports 2026 Jun;46:102593
Biochemistry and biophysics reports 2026 Jun;46:102593
Haizao Yuhu Decoction Inhibits Goiter via p53 Pathway-Induced Apoptosis: Metabolomic and Cellular Assay Analysis.
Liu X, Liao W, Xu X, Wu M, Zhang J, Wu Y, Chen S, Liu H, Zhang S, Xiu L, Zhong G
Biomedical chromatography : BMC 2026 Jun;40(6):e70452
Biomedical chromatography : BMC 2026 Jun;40(6):e70452
Microenvironment-educated MSC-EVs loaded injectable smart hydrogel for targeting senescent nucleus pulposus cells and inhibiting ferroptosis against intervertebral disc degeneration.
Wu W, Cheng Z, Shi P, Gao H, Chen X, Wu W, Yu Z, Yang C, Zhang Y
Bioactive materials 2026 Jul;61:555-576
Bioactive materials 2026 Jul;61:555-576
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Li T, Wang J, Bai L, Zhao Q, Zhu D, Xu Y, Wang Y, Wang Z, Feng F, Zhou X
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Wu L, Tao Y, Xu Y, Liang Z, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
Wang B, Ji T, Zhang Z, Duan Y, Xing Z, Duan J, Zhao S, Jia Y, Wang Q
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma.
Wei J, Duan Y, Xue C, Zheng L, Wei Q, Wu Z, Xin H, Zeng T, Deng H, Fan S, Xiong W, Zeng Z, Li M, Zhou M
Clinical and translational medicine 2026 Jan;16(1):e70583
Clinical and translational medicine 2026 Jan;16(1):e70583
A transcriptome-based tool for assessing skin aging reveals the ameliorative effect of stem cell-derived extracellular vesicles on UVB-induced aging.
Xie J, Wang L, Zhao S, Wang J, Cheng Y, Xu L, Kou T, Chen Y, Ying Y, Xin X, Zhang T, Xu X, Lu D, Hu X, Zhang Y, Qiu C, Wang J, Cheng G, Zhou J, Lei S, Lyu Q, Li J, Pan Y, Cao T
BMC genomics 2026 Jan 8;27(1):146
BMC genomics 2026 Jan 8;27(1):146
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Zhang N, Zhao R, Zhong X, Dong Q, Liu Y, Yu K, Han L, Meng F, Wu J, Chen Q, Li X, Chen Q, Zhang K, Huang H, Zhang J, Wu S, Ren Y, Wang W, Liu Y
Nature communications 2026 Jan 8;17(1):1406
Nature communications 2026 Jan 8;17(1):1406
Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma.
Chen J, Lu W, Lou Y, Liu J, Liao X, Bai Y, Cheng G, Zhu G, Feng J, Liu J, Liu Z, Jia L, Zhou J, Peng T, Lu GD, Wang J
Molecular cancer 2026 Jan 5;25(1):3
Molecular cancer 2026 Jan 5;25(1):3
Integrated activity-guided isolation and transcriptomic analysis reveal the therapeutic mechanism of Thonningianin A from Penthhorum chinense Pursh against colorectal cancer via p21 modulation.
Zeng F, Jiang X, Xiong F, Yao S, Lu W, Chen Y, Yang H, Ye X
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120655
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120655
Epicatechin Gallate Ameliorates UVB-Induced Photoaging by Inhibiting p38α-Mediated Autophagy and Oxidative Stress.
Yang D, Sun R, Cui Y, Li Y, Hou H, Otsuki K, Li W, Xu J, Zhang P, Zhang J
Antioxidants (Basel, Switzerland) 2026 Jan 30;15(2)
Antioxidants (Basel, Switzerland) 2026 Jan 30;15(2)
Suppressing the Aberrant Transcriptional Functionality of EWS::FLI1 Oncoprotein by Designer polyQ Fusions with Its Homologous Peptides.
Duan HT, Zhang XL, Jiang LL, Hu HY
Biomedicines 2026 Jan 30;14(2)
Biomedicines 2026 Jan 30;14(2)
SCHEMBL4796824: a multifaceted antitumor agent targeting microtubule dynamics, DNA damage, and Wnt/β-catenin signaling in ovarian cancer cells.
Ma C, Ding X, Wang B, Zhu X, Zhang Y, Ding M, Ding X, Zhou J, Zuo D, Huang Y, Ma Y, Chen G
Journal of ovarian research 2026 Jan 3;19(1):42
Journal of ovarian research 2026 Jan 3;19(1):42
Ginsenoside Rg1 delays the senescence of adipose-derived stem cells: network pharmacology and experimental validation.
Fang Y, Mou C, Yu X, Zhang J, Zhu W, Zhou C, Jiang B, Chen Y
Hereditas 2026 Jan 27;163(1):31
Hereditas 2026 Jan 27;163(1):31
The prognostic value of miR-323b-5p in non-small cell lung cancer and its mechanism of targeting IL1A in regulating the proliferation and cell cycle of non-small cell lung cancer cells.
Wu Y, Duan Z, Yan D, Yue J, Liu C
Discover oncology 2026 Jan 23;17(1):314
Discover oncology 2026 Jan 23;17(1):314
3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) is a potential diagnostic and prognostic biomarker in colon adenocarcinoma.
Jin A, Yang F, Li H, Wang G, Wang S, Tong S, Gao J
Scientific reports 2026 Jan 18;16(1):5655
Scientific reports 2026 Jan 18;16(1):5655
BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53.
Wang Q, Guo L, Wang S, Guan C, Pan J, Zhu S, Zheng L, Wu X, Gu Y, Shu T, Luo L, Lai T, Gao X
BMC biology 2026 Jan 17;24(1):37
BMC biology 2026 Jan 17;24(1):37
Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis.
Jiang Q, Xu R, Cheng J, Shi Y, Zhu T, Yu M, Cui X, Lin C
Journal of pharmaceutical and biomedical analysis 2026 Jan 15;268:117232
Journal of pharmaceutical and biomedical analysis 2026 Jan 15;268:117232
Engineered microalgae-driven gel platform promotes the repairing of senescence-associated intervertebral disc degeneration in rats and goats.
Wang Y, Xu T, Wang H, Cai X, Gao S, Liang W, Deng Q, Yakefu A, Maimaiti M, Xun C, Ma L, Sheng W
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114500
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114500
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy.
Liu Y, Lin S, Liang L, Cai Z, Zhuang W, Chen X, Gao L, Li S, Lin Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114488
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114488
Inhibition of the PI3K/AKT signaling pathway blocks the oncogenic activity of TRIM26 in prostate cancer cells.
Zhong YY, Zhang LH, Zhou XY, Zhou XM, He YM, Mao XL, Xu XF
Asian journal of andrology 2026 Jan 1;28(1):89-95
Asian journal of andrology 2026 Jan 1;28(1):89-95
Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model.
Zheng ZJ, Chen Y, Chen QX, Tang WH, Chung E, Hong K, Zhang SD, Lin HC
Asian journal of andrology 2026 Jan 1;28(1):80-88
Asian journal of andrology 2026 Jan 1;28(1):80-88
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
Jin L, Wei L, Hua J, Zhang R, Chen J, He J, Yang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
Age-associated methionine sulfoxide reductase A protects against valvular interstitial cell senescence and valvular calcification.
Li Q, Song C, Wei Z, Zhou H, Wang S, Li H, Yang H, Luo Q, Li J, Chen M
GeroScience 2026 Feb;48(1):807-827
GeroScience 2026 Feb;48(1):807-827
Nociceptin-mediated SIRT6 downregulation drives cellular senescence in glioblastoma.
Xu Y, Zhou J, Zhou X, Li Y, Yang S, Xue Z
Neuropeptides 2026 Feb;115:102570
Neuropeptides 2026 Feb;115:102570
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.
Li Y, Jia Z, Liu X, Xia X, Zhang L, Dai H, Li S, Zhou Y, Ma L, Bai Z
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):71
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):71
Antioxidant and anti-aging activities of Salvia miltiorrhiza Bunge callus extracts in H(2)O(2)-induced premature senescence and chronological aging models of human dermal fibroblasts.
Lin SZ, Lin TK, Kuo WW, Kao SW, Kuo CH, Hsieh DJ, Lin YM, Ho TJ, Ng SC, Huang CY
Biogerontology 2026 Feb 7;27(2):54
Biogerontology 2026 Feb 7;27(2):54
FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.
Dai Y, Guo Y, Chen D, Li P, Xue L, Feng Y, Tang W, Wu C, Wei S, Dai J, Jiang D, Wang S, Wu M
Journal of nanobiotechnology 2026 Feb 7;24(1)
Journal of nanobiotechnology 2026 Feb 7;24(1)
UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation.
Shi H, Cai Y, Liu Y
Biological research 2026 Feb 5;59(1)
Biological research 2026 Feb 5;59(1)
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Yan Y, Ren X, Xiao Y, Li F, Guo J, Ji K, Hei Z, Zhang Z, Sun Y
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Zheng X, Huang R, Liu Z, Liu T, Lin H, Yin L, Wu Q, Zhao M
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Cellular Senescence Drives Zinc Accumulation and Transporter Dysregulation in Intestinal Epithelial Cells.
Terrell KC, Choi S, Choi J, Choi S
bioRxiv : the preprint server for biology 2026 Feb 20;
bioRxiv : the preprint server for biology 2026 Feb 20;
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Zhao Z, Fu J, Han J, Pan Y, Xue B, Sun X, Ma Y, Li B, Chen K, Li Z, Liang Z, Zhou X, Guo Y, Tu P
Journal of biological engineering 2026 Feb 2;20(1)
Journal of biological engineering 2026 Feb 2;20(1)
Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.
Fan Y, Wang ZH, Zhang X, Dong Y, Liu X, Luo G, Yang H, Li H, Wang Z, Tang Q, Jin X, Guo DS, Sun T
Journal of nanobiotechnology 2026 Feb 18;24(1)
Journal of nanobiotechnology 2026 Feb 18;24(1)
Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis.
Fang W, Chen C, Nie M, Liu Q, Huang T, Gao C, Liu Y, Zhou X, Wang X
Cell communication and signaling : CCS 2026 Feb 16;24(1)
Cell communication and signaling : CCS 2026 Feb 16;24(1)
Integrated bioinformatics and experimental validation identify CCDC78 as a prognostic biomarker in colon adenocarcinoma.
Mo Q, Du M, Zheng J, Yu J, Ma Z, Zhuang S, Jiang M
Scientific reports 2026 Feb 12;16(1)
Scientific reports 2026 Feb 12;16(1)
Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance.
Wu P, Zhou J, Wang J, Wu Y, Wang H, Zhao L
mBio 2026 Feb 11;17(2):e0344125
mBio 2026 Feb 11;17(2):e0344125
Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy.
Cui Y, Li L, He Y, Shan S, Liu L, Ren J, Wang H, Yang M, Zhao X, Jia J, Wang P
Annals of medicine 2026 Dec;58(1):2635821
Annals of medicine 2026 Dec;58(1):2635821
Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression.
Ruan J, Xie Y, Zhang C, Sun D
Cell adhesion & migration 2026 Dec;20(1):2658289
Cell adhesion & migration 2026 Dec;20(1):2658289
Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence.
Jia X, Hu X, Fu Z, Zhang L, Luo X, Huang W, Hua Y, Fang Q, Zeng J, Huang F, Wei G, Bin J, Zheng H, Chen G, Huang S
Biomaterials 2026 Aug;331:124109
Biomaterials 2026 Aug;331:124109
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
Chuang YF, Wu CR, Chang WH, Su YJ, Hsu HT, Lin FL, Lo YC
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
A Biologically Lubricating Allicin-Based Nanoplatform for Remodeling the Inflammation-Senescence Axis in the Treatment of Periodontitis.
Sun G, Yang Y, Ren J, Huang K, Zhang G, Wang Y, Zhao L, Liu Z, Zhang H, Zhang L
Advanced materials (Deerfield Beach, Fla.) 2026 Apr;38(19):e23197
Advanced materials (Deerfield Beach, Fla.) 2026 Apr;38(19):e23197
3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair.
Wang C, Wang Y, Li X, Cao H, Wang C, Han S, Chen H, Zhao X, Yang S
Materials today. Bio 2026 Apr;37:102879
Materials today. Bio 2026 Apr;37:102879
PLLP inhibits the progression of WT p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59.
Quan Z, Lin L, Xu F, Zhou C, Huang R, Sun K, Jiang H
The Journal of biological chemistry 2026 Apr;302(4):111341
The Journal of biological chemistry 2026 Apr;302(4):111341
Trichosanthes kirilowii extract alleviated liver fibrosis and acute myocardial infarction by inhibiting VCAN to restrain monocyte senescence: Insights from bioinformatic analyses and experimental validation.
Li Z, Wei S, Fu G, Liu R, Zhang S, Liu W, Pan T, Zhang Y, Wen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157941
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157941
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;
Nature aging 2026 Apr 6;
AnnoNet-TCMs: An annotation network-driven discovery of novel active compounds and mechanisms in traditional Chinese medicine.
Yan X, Guo Z, Zhou F, Cui Y, Zhang Z, Jing Z, Wang L, Fan Z, Lu J, Xing X, Yang H
Journal of advanced research 2026 Apr 5;
Journal of advanced research 2026 Apr 5;
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Du W, Liu A, Li H, Ma X, Yang Y
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
Wu Y, Mao J, Zhou Y, Hong G, Wu H, Hu Z, Huang X, Shi J, Xie Z, Lan Y
Research (Washington, D.C.) 2025;8:0644
Research (Washington, D.C.) 2025;8:0644
NLR Risk Score for Predicting Patient Prognosis in Hepatocellular Carcinoma and Identification of Oncogenic Role of NLRP5 in Hepatocellular Carcinoma.
Tang M, He S, Meng B, Zhang Q, Li C, Sun Y, Sun W, Wang C, Kong Q, Liu Y, Hu L, Gao Y, Xie Q, Li J, Wu T
Oncology research 2025;33(10):3077-3100
Oncology research 2025;33(10):3077-3100
DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy.
Li D, Su H, Deng X, Huang Y, Wang Z, Zhang J, Chen C, Zheng Z, Wang Q, Zhao S, Chen ZS, Chen H, Hou L, Tan W, Li F
International journal of biological sciences 2025;21(4):1530-1544
International journal of biological sciences 2025;21(4):1530-1544
PRMT1/PRMT5-Mediated Differential Arginine Methylation of CRIP1 Promotes the Recurrence of Small Cell Lung Cancer after Chemotherapy.
Han Y, Ma L, Zhang X, Ren Q, Yuan Q, Zhou J, Ren Y, Wan N, Jin X, Hou J, Wang Y, Huang B, Zhang Y, Lu J
International journal of biological sciences 2025;21(13):5956-5974
International journal of biological sciences 2025;21(13):5956-5974
Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling.
Xu Y, Zheng J, Liu M, Fu Z, Wang P
Stem cells international 2025;2025:7639451
Stem cells international 2025;2025:7639451
Caffeine Alleviates Oxidative Damage of Retinal Pigment Epithelium Cells.
Liu H, Zhang W, Xiong Y, Yang M, Long H, Gong C, Li S
Journal of ophthalmology 2025;2025:6121757
Journal of ophthalmology 2025;2025:6121757
Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.
Xiao Y, Tao M, Yu Y, Bai R, Zhuang Y, Huang Q, He J, Lin Z, Gao M, Li J, Wang Y, Xu Y, Shen X, Huang Z, Yao Y, Chen Z, Chen Q, Wang Z
Journal of inflammation research 2025;18:12801-12816
Journal of inflammation research 2025;18:12801-12816
EIF4A3 Promotes Cell Proliferation via CDC5L Upregulation in Human Breast Cancer Cells.
Zhang M, Xie Y, Song S, Wang R, Chen H, Li Y, Liu J, Li J, Jiang Y, Liu P, Wang B
Journal of Cancer 2025;16(6):1958-1970
Journal of Cancer 2025;16(6):1958-1970
Overexpression of MCM3 as a prognostic biomarker correlated with cell proliferation, cell cycle and immune regulation in hepatocellular carcinoma.
Ju L, Wang H, Luo Y, Wang Y, Chen L, Han X, Lu R
Journal of Cancer 2025;16(5):1538-1554
Journal of Cancer 2025;16(5):1538-1554
Capsaicin, the Pungent Component of Red Chili Pepper, induces p21-mediated Cell Cycle Arrest in Renal Cell Carcinoma via Downregulating GLI1: an Experimental Research In Vitro.
Zheng L, He Y, Huang H, Qu W
Journal of Cancer 2025;16(15):4284-4291
Journal of Cancer 2025;16(15):4284-4291
Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.
Wu M, Chen C, Ren D, Du Z, Liu Z, Liu W
Frontiers in pharmacology 2025;16:1739201
Frontiers in pharmacology 2025;16:1739201
A new SO(2) probe ZSO targeting VDBP inhibits high glucose induced endothelial cell senescence and calcification.
Zhang Y, Yan X, Dong X, Zhao C, Chi X, Zhao B, Miao J, Lin Z
Frontiers in physiology 2025;16:1719853
Frontiers in physiology 2025;16:1719853
Anticancer activity of MDM2 inhibition in 2D and bioprinted 3D retinoblastoma cell models.
Bompan F, Lodi G, Foschi R, Dipinto A, Cosenza LC, Casciano F, Severi P, Sanvido A, Caruso L, Giari L, Zauli G, Voltan R, Romani A
Frontiers in pharmacology 2025;16:1692250
Frontiers in pharmacology 2025;16:1692250
3D-cultured hADSCs-derived exosomes deliver circ_0011129 to synergistically attenuate skin photoaging.
Zhang Y, Zhou F, Nie G, Li L, Wen J, He S, Yao A
Frontiers in genetics 2025;16:1627472
Frontiers in genetics 2025;16:1627472
METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p.
Huang G, Sun S, Liao M, Wang J, Yan Q, Li J, Meng Y, Wang Q, Guo Z, Tan J, Li J
Frontiers in immunology 2025;16:1577783
Frontiers in immunology 2025;16:1577783
Dissecting the multi-omics landscape of TEAD1 in hepatocellular carcinoma: cycle regulation and metastatic potential.
Huai R, Mao C, Xiong L
Frontiers in immunology 2025;16:1567969
Frontiers in immunology 2025;16:1567969
Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice.
Wang R, Yang F, Liu Y, Peng M, Yu L, Hou Q, Liu Y, Cheng Z
Frontiers in pharmacology 2025;16:1506518
Frontiers in pharmacology 2025;16:1506518
Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1.
Zhou H, Zhang X, Wang Y, Wu Y, Wang L, Hu C, Zhang T, Zhang H, You D, Zhao M, Zhao M, Li A, Chen G
Frontiers in oncology 2025;15:1643155
Frontiers in oncology 2025;15:1643155
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
Guo X, Zhang S, Sun Q, Li H, Wang L
Frontiers in medicine 2025;12:1627412
Frontiers in medicine 2025;12:1627412
IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury.
Su H, Lin X, Paredong A, Yao C, Zhang Y, Geng M, Guan Y, Gong L, Jiang F, Lv Q, Shou S, Jin H
Frontiers in molecular biosciences 2025;12:1538526
Frontiers in molecular biosciences 2025;12:1538526
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.
Zhang X, Wang Y, Wang J, Zhang Y, Li R, Wang X, Ge X, Ye Q, Ji J, Fei D, Wang Q
Journal of advanced research 2025 Sep;75:377-388
Journal of advanced research 2025 Sep;75:377-388
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.
Zhan Y, Deng Z, Yang R, Chen S, Zhang J, Zhang Y, Fu H, Huang Q, Gu Y, Zeng Z, Chen J, Zhang J, Wu J, Xie J
MedComm 2025 Sep;6(9):e70345
MedComm 2025 Sep;6(9):e70345
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.
Pu Q, Gao F, Xiao Y, Wu J, Wang C, Mo X, Zhang Z, Zheng R, Wu D
Toxicology 2025 Sep;516:154193
Toxicology 2025 Sep;516:154193
Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression.
Deng K, Li M, Li Y, Xiang L, Wang Y, Shi H, Cheng J, Huang S, Lv Z
Journal of ginseng research 2025 Sep;49(5):574-584
Journal of ginseng research 2025 Sep;49(5):574-584
Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD(+) metabolism and promoting IDO2/QPRT expression.
Guo C, Wu MX, Zhang ZP, Li J, Chen JJ, Su H, Wei K, Zhao DQ, Li XY, Huang QX
Journal of ginseng research 2025 Sep;49(5):541-552
Journal of ginseng research 2025 Sep;49(5):541-552
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation.
Luo Y, Zeng Y, Liu Y, Liu S, Dai Y, Pan W, Zhang L, Zhu R, Feng D, Du K, Zhang X, Jia B, Tian F, Zhou L, Gu C
Oncogene 2025 Sep;44(34):3096-3112
Oncogene 2025 Sep;44(34):3096-3112
Identification and validation of the pivotal role of MANF gene in pancreatic β-cell aging using bioinformatics.
Liu J, Wang Y, Yang J, Dong X, Zhu Q, Yuan C, Jiang B, Lu G, Yang W, Ma Y
Biochemistry and biophysics reports 2025 Sep;43:102106
Biochemistry and biophysics reports 2025 Sep;43:102106
Human iPSCs Derived MSCs-Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration.
Xiang Q, Zhan J, Tian S, Zhao Y, Wu Z, Lin J, Chen L, Wang L, Jiang S, Sun Z, Li W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e04347
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e04347
Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy.
Rullo A, Flowers B, Chang K, Zhang A, Petukhova VZ, Harding L, Aboagye SY, Bocchetta M, Qiu W, Williams DL, Angelucci F, Petukhov PA, Kastrati I
bioRxiv : the preprint server for biology 2025 Sep 9;
bioRxiv : the preprint server for biology 2025 Sep 9;
A TP53 Intron-Derived Peptide Promotes Tumor Survival.
Cadena LA, Luo KL, Otero-Perez CA, Fernandez SM, Huang YW, Zhao R, Lee DF, Ting AH, Ye F, You MJ, Lee SH
bioRxiv : the preprint server for biology 2025 Sep 9;
bioRxiv : the preprint server for biology 2025 Sep 9;
Ginsenoside Rh2 ameliorates pulmonary fibrosis via HSP70-dependent autophagic flux regulation and senescence arrest.
Zhang WX, Li K, Li WL, Wang JQ, Gao XF, Zhang S, Zhang M, Jiang S, Li W
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120448
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120448
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.
Zhang H, Wang Z, Liu Z, Li X, Sun W, Zhen W, Xu F, Wang R, Yin Q, Cao S, Wu M, He J, Xu J, Li Y, Yuan Q
Bone research 2025 Sep 24;13(1):80
Bone research 2025 Sep 24;13(1):80
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Imbalanced chromatin distribution in cellular senescence specifies paraspeckle dynamics.
Lee J, Choi J, Park J, Lee S, Cho EJ, Gwon Y
Genome biology 2025 Sep 2;26(1):264
Genome biology 2025 Sep 2;26(1):264
Transplanting neural stem cells overexpressing miRNA-21 can promote neural recovery after cerebral hemorrhage through the SOX2/LIN28-let-7 signaling pathway.
Dai W, Li Y, Du J, Shen G, Fan M, Su Z, Xu F, Yuan F
Animal models and experimental medicine 2025 Oct;8(10):1760-1774
Animal models and experimental medicine 2025 Oct;8(10):1760-1774
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity.
Zhang L, Gong H, Gong X, Zhou B, Wang X, Fei S, Xia D, Xu C, Huang X
Bioactive materials 2025 Oct;52:213-227
Bioactive materials 2025 Oct;52:213-227
Canagliflozin improves high-salt-induced aortic arteriosclerosis and premature aging in dahl salt-sensitive rats through the SIRT6/HIF-1 α signaling pathway.
Wang Q, Liang Y, Zuo Q, He L, Zhang T, Wang Z, Zhai J, Cao B, Ma S, Zhang G, Lu F, He K, Wang Y, Guo Y
Molecular and cellular biochemistry 2025 Oct;480(10):5369-5385
Molecular and cellular biochemistry 2025 Oct;480(10):5369-5385
Chemokines and PI3K/AKT signaling pathway mediate the spontaneously ruptured hepatocellular carcinoma through the regulation of the cell cycle.
Zhang Y, Zhou YL, Xu N, Meng T, Wang ZZ, Pan FM, Zhu LX
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Oct;24(5):511-526
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Oct;24(5):511-526
Dietary Citrate Restores Age-Related Endothelial Cell Mitochondrial Dysfunction and Alleviates Atherosclerosis.
Zhao Y, Qiu JY, Wu F, Gong XT, Lv WX, Liu JK, Dong JY, Li XE, Wu AD, Duan JJ, Xiang Y, Tian XL
Aging cell 2025 Oct;24(10):e70213
Aging cell 2025 Oct;24(10):e70213
Translating m6A-Glycolysis Discovery into Therapy: GOQD-Based Multifunctional Bioactive Scaffolds Rejuvenates Bone Repair in Senescence.
Wang Z, Deng T, Chang H, Li Y, Zhang Y, Jiao X, Gan Y
Small (Weinheim an der Bergstrasse, Germany) 2025 Oct;21(43):e07315
Small (Weinheim an der Bergstrasse, Germany) 2025 Oct;21(43):e07315
Mesenchymal stem cells and cancer stem cells promote colorectal cancer cell growth and biological functions via cell-cell indirect contact.
Liu Y, Zhao J, Yang B, Yang X, Chen J, Cheng J, Yuan X, Liu G, Xu X, Li Y, Tang D, Wang F
Cancer cell international 2025 Oct 8;25(1):344
Cancer cell international 2025 Oct 8;25(1):344
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis.
Huang H, Tang M, Hu P, Zhan Y, Sun W, Zheng W, Zhu J, Chen J, Xue S, Huang S, Han W, Zhang C, Ding C, Zhang Y, Li S, Ruan G
Journal of nanobiotechnology 2025 Oct 31;23(1):695
Journal of nanobiotechnology 2025 Oct 31;23(1):695
A novel non-nad-based PARP1 inhibitor, Japoflavone B, triggered Caspase-3/GSDME-mediated pyroptosis through ROS/p38/p53 pathway in NSCLC.
Wan H, Wei J, Wang Y, Ge L, Hu Q, Li Y, Zhou B, Zeng X
Chemico-biological interactions 2025 Oct 22;420:111693
Chemico-biological interactions 2025 Oct 22;420:111693
SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence.
Xianhong Z, Yue G, Yu Z, Yichen Z, Yufei C, Xinke P, Jinhui Z, Yiqi W, Yitian D, Shuailin H, Ting N
Communications biology 2025 Oct 20;8(1):1485
Communications biology 2025 Oct 20;8(1):1485
RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis.
Chen D, Xie F, Mo Y, Qin D, Zheng B, Chen L
Cellular & molecular biology letters 2025 Oct 2;30(1):109
Cellular & molecular biology letters 2025 Oct 2;30(1):109
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.
Wang J, Yang X, Su X, Yi W, Sun W, Wei J, Ning YQ, Yan J
Journal of translational medicine 2025 Oct 17;23(1):1127
Journal of translational medicine 2025 Oct 17;23(1):1127
SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging.
Chen X, Zhang Y, Zhao Y, Zhou M, Cheng P, Yang H, Shu Y, Duan L, Wu Y, Sun Y, Gao Y, Zhao K, Xiao Q, Yu J
Experimental gerontology 2025 Oct 15;210:112880
Experimental gerontology 2025 Oct 15;210:112880
The long non-coding RNA, CyKILRb, augments oncogenic phenotypes via induction of PIK3R2 and activation of the PI (3) K/AKT axis.
Xie X, Macknight HP, Lu AL, Chalfant CE
bioRxiv : the preprint server for biology 2025 Oct 14;
bioRxiv : the preprint server for biology 2025 Oct 14;
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Yang L, Wang W, Zhang A
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer.
Yao X, Shen X, Fan Y, Wang H
NPJ breast cancer 2025 Oct 1;11(1):108
NPJ breast cancer 2025 Oct 1;11(1):108
FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA.
He Q, Li H, Cong Y, Chen K, Cheng L, Lv F, Zhang P, Ju Y, Yu Z, Chen J, Wang C, Song Y, Li X, Chen L, Xing Y
Neoplasia (New York, N.Y.) 2025 Nov;69:101227
Neoplasia (New York, N.Y.) 2025 Nov;69:101227
Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the IκB/NF-κB pathway to accelerate osteoarthritis.
Yao Z, Yuan Z, Li Y, Li X, Peng C, Jin J, Zhang H, Bai X, Pan J, Cai D
Journal of orthopaedic translation 2025 Nov;55:360-375
Journal of orthopaedic translation 2025 Nov;55:360-375
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Huang C, Chen X, Wu D, Chen J, Wang J, Li S, Hu J, Yan Z, Zhu Y, Zhang Y
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
Galectin-9 promotes colon cancer development by polarizing macrophages toward the M2 phenotype.
Zhang J, Xu Y, Han X, Gao Y, Wei Z, Sun X
Cancer genetics 2025 Nov;298-299:141-150
Cancer genetics 2025 Nov;298-299:141-150
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
Loadless Tendon Explant Model Exhibits Spontaneous Degradative Phenotypes: An In Vitro Study of Human Tendons.
Chen BS, Yuan YJ, Wang YL, Yang SY, Li WC, Guo JW
Journal of clinical medicine research 2025 Nov;17(11):634-641
Journal of clinical medicine research 2025 Nov;17(11):634-641
Camptothecin 20(S)-sulfonyl amidine derivative inhibits gastric cancer cell proliferation by targeting topoisomerase I to trigger the DNA damage-apoptosis cascade.
Si Z, Ma Y, Cheng Z, Zhang B, Yang M, Wang C, Liu Y, Fang H, Li Y, Zhao F, Liu Y, Chen P
Bioorganic chemistry 2025 Nov;166:109171
Bioorganic chemistry 2025 Nov;166:109171
Biotransformation of steroid hormones by intestinal fungi and their special cytotoxicity on HeLa cancer cells.
Tian M, Han C, Hu Y, Luan S, Tian X, Guo P, Li X, Sui L, Wang C, Ma X, Li D
Bioorganic chemistry 2025 Nov;166:109102
Bioorganic chemistry 2025 Nov;166:109102
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
Fan Y, Chen Y, Lu W, Shi K, Zhao Y, Zhang C, Shen Z, Zheng S, Jie W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157215
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157215
Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.
Jiao L, Yan Q, Yang J, Wu R, Wei Z, Ruan J, Yan G, Chen X, Li H
Cellular signalling 2025 Nov;135:112075
Cellular signalling 2025 Nov;135:112075
Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis.
Lu J, Wang J, Liu Y, Zhang C, Zhang G, Ge Y, Liu L
Cardiovascular diabetology 2025 Nov 8;24(1):427
Cardiovascular diabetology 2025 Nov 8;24(1):427
Persistent Activation of Monocytes/Macrophages and Cell Senescence in SIV-Infected Macaques on ART.
Chen Y, Ding X, Ray S, Thirugnanam S, Blair R, Saied A, Sukhanov S, Kolls J, Kim WK, Delafontaine P, Rappaport J, Qin X, Rout N
bioRxiv : the preprint server for biology 2025 Nov 6;
bioRxiv : the preprint server for biology 2025 Nov 6;
The DNA-PKcs-primary cilia axis maintains ionizing radiation-induced senescence in tumor cells.
Liu X, Wei L, Zhang R, Chen J, Zhang T, Hua J, Wang J, He J, Xie X
Acta biochimica et biophysica Sinica 2025 Nov 3;
Acta biochimica et biophysica Sinica 2025 Nov 3;
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Li Y, Xu L, Lu X, Fu B, Jiang Q, Xiong W, Tang W, Wu D
Digestive diseases and sciences 2025 Nov 29;
Digestive diseases and sciences 2025 Nov 29;
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Tang Z, Guo C, Wen N, Jin H, Dong Y, Xu B, Ma X, Han L, Liu J
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.
Wu J, Dongzhu N, Zhao C, Liang J, Wang N, Suonan D, Sun S
International journal of molecular sciences 2025 Nov 25;26(23)
International journal of molecular sciences 2025 Nov 25;26(23)
Hyperoside Promotes Mitochondrial Autophagy Through the miR-361-5p/PI3K/Akt/mTOR Signaling Pathway, Thereby Improving UVB-Induced Photoaging.
Yang D, Le J, Xiao S, Cui Y, Zhu W, Otsuki K, Li W, Xu J, Feng F, Zhang J
Antioxidants (Basel, Switzerland) 2025 Nov 25;14(12)
Antioxidants (Basel, Switzerland) 2025 Nov 25;14(12)
ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC.
Qin W, Shao L, Li Q, Zhang D, Jia X, Dong C
Molecular cancer 2025 Nov 20;24(1):295
Molecular cancer 2025 Nov 20;24(1):295
KIF11 variants in familial exudative vitreoretinopathy leading to mTORC1 overactivation and impaired cell cycle progression.
Liu M, Pan S, Dai E, Zhao R
Human genomics 2025 Nov 19;19(1):135
Human genomics 2025 Nov 19;19(1):135
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Tau impedes glioma progression by enhancing fatty acid β-oxidation-induced cellular senescence.
Han WH, Zhao WJ, He JW, Zhao WP, Lu HW, Lu ZW, Qiu XS, Chang C, Zhang YY, Xie YY, Geng YY, Zhang BC, Wang ZX
Zoological research 2025 Nov 18;46(6):1304-1316
Zoological research 2025 Nov 18;46(6):1304-1316
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Han L, Tang Z, Ma X, Zhang Q, Han Y, Wang Q, Liu J, Bian X, Gao L, Xu M, Sun X
International journal of molecular sciences 2025 Nov 18;26(22)
International journal of molecular sciences 2025 Nov 18;26(22)
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Dong Q, Dong L, Zhu Y, Wang X, Yan X
Functional & integrative genomics 2025 Nov 17;25(1):244
Functional & integrative genomics 2025 Nov 17;25(1):244
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence.
Feng L, Zhong Y, Li L, Zhang M, Zhu M, Wang J, Huang M, Ji N, Ma Y
International immunopharmacology 2025 Nov 14;165:115426
International immunopharmacology 2025 Nov 14;165:115426
A senescence-responsive nanodrug amplifies radiotherapy efficacy.
Hua Y, Song H, Deng H, Tian H, Liu C, Wu H, Wang S, Shao C, Ye L, Ge S, Leong KW, Yu J, Ruan J
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114202
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114202
NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial-Mesenchymal Transition in Liver Cancer.
Liu Y, Mo W, Sun W, Chen J, Chen J, Li Y, Han D, Dai W, Zhang R
Digestive diseases and sciences 2025 May;70(5):1799-1812
Digestive diseases and sciences 2025 May;70(5):1799-1812
USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53.
Zhu Y, Chen Z, Niu K, Li M, Deng Y, Zhang J, Wei D, Wang J, Zhao Y
Cell proliferation 2025 May;58(5):e13793
Cell proliferation 2025 May;58(5):e13793
Design and Synthesis of O-Dialkylaminoalkyl Substituted Urolithin Derivatives: DNA Topoisomerase IIα Inhibition With Promising Antiproliferative Activity.
Li X, Zhang X, Yin C, Lu C, Shen Y
Archiv der Pharmazie 2025 May;358(5):e70009
Archiv der Pharmazie 2025 May;358(5):e70009
TFDP1 drives triple-negative breast Cancer development through senescence suppression and serves as a therapeutic target for topotecan.
Ju G, Lin Q, Lu L, Lin Z, Huang D, Lin Y, Huang X, Lin Q, Xu H, Bai Y, Miao S, Li J, Song J, Chen J
International journal of biological macromolecules 2025 May;310(Pt 4):143543
International journal of biological macromolecules 2025 May;310(Pt 4):143543
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
Chen K, Qin C, Ji C, Yu Y, Wu Y, Xu L, Jiang Y, Zou G
International journal of biological macromolecules 2025 May;310(Pt 3):143285
International journal of biological macromolecules 2025 May;310(Pt 3):143285
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Zhu ZM, Huo FC, Shi C, Li MT, Zhou Y, Zhang LS, Pei DS
International journal of biological macromolecules 2025 May;309(Pt 2):142880
International journal of biological macromolecules 2025 May;309(Pt 2):142880
Knockdown of C3aR alleviates age-related bone loss via activation of YAP1/β-catenin signaling.
Li F, Cui S
The Journal of biological chemistry 2025 May;301(5):108500
The Journal of biological chemistry 2025 May;301(5):108500
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Luo S, Wu F, Jin Y, Liu D
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6.
Senatore E, Avolio R, Rinaldi L, Chiuso F, Oliva MA, D'Ambrosio C, Bianco AG, Dalla E, Pagnotta SM, Flammia R, Ambrosino C, Memoli D, Turacchio G, Mimoune SI, Toiron Y, Audebert S, Camoin L, Lignitto L, Scaloni A, Arcella A, Feliciello A
EMBO reports 2025 May;26(9):2347-2377
EMBO reports 2025 May;26(9):2347-2377
Expression, characterization and anti-colon cancer activity of recombinant ginseng peptides with amino acid tandem repeats.
Feng Y, Li W, Yuwen W, Xu R, Zhu C, Duan Z, Fan D
Protein expression and purification 2025 May;229:106663
Protein expression and purification 2025 May;229:106663
Resveratrol Promotes Wound Healing by Enhancing Angiogenesis via Inhibition of Ferroptosis.
Pan Y, Xia M, Luo J, Lu S
Food science & nutrition 2025 May;13(5):e70254
Food science & nutrition 2025 May;13(5):e70254
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
Zhao H, Gao X, Jiang Y, Yu Y, Wang L, Sun J, Wang M, Xiong X, Huang C, Zhang H, Jiang G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways.
Shan L, Gu GJ, Xiang CC, Zuo ED, Lian L, Cheng X
BioFactors (Oxford, England) 2025 May-Jun;51(3):e70023
BioFactors (Oxford, England) 2025 May-Jun;51(3):e70023
Modulation of senescent Lepr(+) skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression.
Yu FH, Yin BF, Liu MY, Zhang WJ, Zhao ZD, Wang L, Li XT, Li PL, Li ZL, Xu RX, Ding L, Zhu H
Stem cell research & therapy 2025 May 5;16(1):227
Stem cell research & therapy 2025 May 5;16(1):227
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
Sun C, Du Z, Yang W, Wang Q
Discover oncology 2025 May 30;16(1):952
Discover oncology 2025 May 30;16(1):952
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells.
Lin SQ, Tian N, Yao X, Pan XH, Li ZA, Wang Q, Gao J, Zhao XL, Ruan GP
Stem cell research & therapy 2025 May 30;16(1):267
Stem cell research & therapy 2025 May 30;16(1):267
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
Liang X, Zhang J, Yu J, Zhao J, Yang S
European journal of medical research 2025 May 3;30(1):359
European journal of medical research 2025 May 3;30(1):359
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.
Gao Y, Xu H, Zhao Q, Cai D, Zhou X, Chen X, Yuan S, Li D, Ning T, Dong X, Li M, Li G, Nan A
Cell biology and toxicology 2025 May 28;41(1):91
Cell biology and toxicology 2025 May 28;41(1):91
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors.
Gao Y, Zuo L, Zheng Y, Sun K, Gao Y, Xu X, Li Z, Zuo D
Breast cancer research : BCR 2025 May 26;27(1):92
Breast cancer research : BCR 2025 May 26;27(1):92
Remodeling the Senescent Microenvironment for Promoting Osteoporotic Tendon-to-Bone Healing via Synergizing Senolytic Quercetin and Aligned Nanowire-Structured Hydrogels.
Song W, Liu W, Li SY, Yu Y, Xu H, Shi T, Yu HP, He Y, Zhu YJ, Yu W
ACS nano 2025 May 20;19(19):18364-18385
ACS nano 2025 May 20;19(19):18364-18385
GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement.
Chan KY, Yu Y, Kong Y, Cheng L, Yao R, Yin Chair PS, Wang P, Wang R, Sun WY, He RR, Min J, Wang F, Björklund M
iScience 2025 May 16;28(5):112363
iScience 2025 May 16;28(5):112363
Ginsenoside CK and retinol on UVA-induced photoaging exert the synergistic effect through antioxidant and antiapoptotic mechanisms.
Zhang J, Li Z, Song X, Cai P, Liu Q
Scientific reports 2025 May 13;15(1):16664
Scientific reports 2025 May 13;15(1):16664
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Chen J, Gan X, Su S, Jiao S, Gong Z, Liu Z, Wu X, Jiang J, Zhang J, Wan J
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Phase separation of MRG15 delays cellular senescence.
Li Y, Jin X, Yu C, Zuo M, Hong L, Wang M, Zhao C, Wu A, Wang J, Ju Z, Wang H
Communications biology 2025 May 1;8(1):688
Communications biology 2025 May 1;8(1):688
Investigating the role of IL-6 in the pathogenesis of systemic lupus erythematosus: Insights from bone marrow mesenchymal stem cells.
Zhang Z, Zhu S, Li Q, Wei S, Yin L, Zhu J, Yang S, Zhang W, Lai K
Lupus 2025 Mar;34(3):225-233
Lupus 2025 Mar;34(3):225-233
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
Wang L, Song J, Yang Z, Zhang H, Wang Y, Liu J, Wang S, Shi J, Tong X
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
Astragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated m(6)A methylation.
Wang SW, Li P, Liu SY, Huang DL, Zhang SJ, Zeng XX, Lan T, Mao KL, Gao Y, Cheng YF, Shen Q, Ruan YP, Mao ZJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156408
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156408
AP2A1 modulates cell states between senescence and rejuvenation.
Chantachotikul P, Liu S, Furukawa K, Deguchi S
Cellular signalling 2025 Mar;127:111616
Cellular signalling 2025 Mar;127:111616
Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A.
Li X, Wang Q, Fei J, Jin Z, Wu Y, Tao Y, Jiang C, Wang X, Yang N, Ding B, Dou C
Placenta 2025 Mar 6;161:39-51
Placenta 2025 Mar 6;161:39-51
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy.
Wang Y, Huang J, Song Z, Zhang S, Guo H, Leng Q, Fang N, Ji S, Yang J
Biology direct 2025 Mar 27;20(1):37
Biology direct 2025 Mar 27;20(1):37
Targeting senescence in Amyotrophic Lateral Sclerosis: senolytic treatment improves neuromuscular function and preserves cortical excitability in a TDP-43(Q331K) mouse model.
Viteri JA, Kerr NR, Brennan CD, Kick GR, Wang M, Ketabforoush A, Snyder HK, Moore PJ, Darvishi FB, Dashtmian AR, Ayyagari SN, Rich K, Zhu Y, Arnold WD
Research square 2025 Mar 26;
Research square 2025 Mar 26;
Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality.
Zhang XL, Yue HW, Liu YJ, Wang JY, Duan HT, Liu YH, Jiang LL, Hu HY
iScience 2025 Mar 21;28(3):112025
iScience 2025 Mar 21;28(3):112025
Multi-Water Bridges Enable Design of BET BD1-Selective Inhibitors for Pancreatic Cancer Therapy.
Chen X, Kang W, Wu T, Cao D, Chen Y, Du Z, Yan L, Meng F, Wang X, You Q, Xiong B, Guo X, Jiang Z
Journal of medicinal chemistry 2025 Mar 13;68(5):5719-5735
Journal of medicinal chemistry 2025 Mar 13;68(5):5719-5735
Metformin-Loaded Tannic Acid Nanoparticles Attenuate Osteoarthritis by Promoting Chondrocyte Mitochondria Homeostasis Based on Mitocytosis.
Da W, Deng X, Chen Q, Yang Y, Jiang S, Chen X, Lu G, Shen B
Biomacromolecules 2025 Mar 10;26(3):1507-1519
Biomacromolecules 2025 Mar 10;26(3):1507-1519
Tasquinimod promotes the sensitivity of ovarian cancer cells to cisplatin by down-regulating the HDAC4/p21 pathway.
Li Z, Wu YH, Guo YQ, Min XJ, Lin Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Mar 1;29(2):191-204
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Mar 1;29(2):191-204
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells.
Huang Y, Zhang Y, Yang N, Qian Z, Fang Z, Zeng L, Huang Y, Li H, Luo M, Yan J, Ruan L, Zhang C, Zhang L
GeroScience 2025 Jun;47(3):5089-5110
GeroScience 2025 Jun;47(3):5089-5110
Rictor orchestrates β-catenin/FOXO balance by maintaining redox homeostasis during development of ovarian cancer.
Zhao X, Lai H, Li G, Qin Y, Chen R, Labrie M, Stommel JM, Mills GB, Ma D, Gao Q, Fang Y
Oncogene 2025 Jun;44(23):1820-1832
Oncogene 2025 Jun;44(23):1820-1832
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Zhang M, Liu R, Jiang W, Li H, Zhang S, Cheng W, Ye X, He J, Liu Y, Jing A, Song Y, Wang D, Liu X, Zhang B, Wang X, Ji J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Fe-curcumin nanozymes-mediated reactive oxygen species scavenging and anti-apoptotic effects on age-related cataracts.
Gao X, Li K, Huang Y, Long Z, Xiang Y, Zheng W, Cheng H, Cao H, Wan W, Zheng S, Wang X, Hu K
Materials today. Bio 2025 Jun;32:101850
Materials today. Bio 2025 Jun;32:101850
A multifunctional parathyroid hormone-related supramolecular peptide-loaded dual network hydrogel for radiation-induced wound repair.
Zhu M, Shi G, Chen R, Li Z, Wang J, Wu Z, Guo L, Wei Y, Li J
Materials today. Bio 2025 Jun;32:101807
Materials today. Bio 2025 Jun;32:101807
Doxorubicin-induced senescence is modulated by the eukaryotic release factor 3a and its polyglycine expansion in HCT116 cells.
Jolles B, Stierlé V
Biochimie 2025 Jun;233:81-87
Biochimie 2025 Jun;233:81-87
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Bian Z, Zhai Y, Zhang Y, Wang T, Li H, Ouyang J, Liu C, Wang S, Hu Z, Chang X, Zhang C, Liu M, Li C
Free radical biology & medicine 2025 Jun;233:39-54
Free radical biology & medicine 2025 Jun;233:39-54
20(S)-ginsenoside Rg3 suppresses gastric cancer cell proliferation by inhibiting E2F-DP dimerization.
Li F, Cai C, Wang F, Zhang N, Zhao Q, Chen Y, Cui X, Wang S, Zhang W, Liu D, Cai Y, Jin J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156740
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156740
Mai-wei-yang-fei decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation.
Wang J, Zhao Y, Wei Y, Li T, Huang T, Pan T, Wu J, Bai L, Zhu D, Zhao Q, Wang Z, Feng F, Zhou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156682
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156682
EFNA1 promotes the tumorigenesis and metastasis of cervical cancer by phosphorylation pathway and epithelial-mesenchymal transition.
Dong X, Chen X, Xue M, Zhang Y, Jiang P
Acta histochemica 2025 Jun;127(2):152236
Acta histochemica 2025 Jun;127(2):152236
Effect of COL11A1 on oral squamous cell carcinoma.
Liu YH, Li D, Zhang HL, Zhang BH, Song WJ, Li TK
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102183
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102183
Charting the regulatory landscape of TP53 on transposable elements in cancer.
Qu X, Liang Y, McCornack C, Xing X, Schmidt H, Tomlinson C, Fronick C, Belter EA Jr, Macias-Velasco JF, Wang T
Genome research 2025 Jun 2;35(6):1456-1471
Genome research 2025 Jun 2;35(6):1456-1471
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice.
Xu L, Li T, Cao Y, He Y, Shao Z, Liu S, Wang B, Su A, Tian H, Li Y, Liang G, Wang C, Shyy J, Xiong Y, Chen F, Yuan JX, Liu J, Zhou B, Wettschureck N, Offermanns S, Yan Y, Yuan Z, Wang S
The Journal of clinical investigation 2025 Jun 2;135(11)
The Journal of clinical investigation 2025 Jun 2;135(11)
Study on the role of miR-10b-3p as SASP in exosomes of premature senescent hepatocytes induced by hexavalent chromium.
Liang Q, Huang Z, Wang D, Xin F, Xu J, He J, Luo R, Zeng Y, Ma Y
Ecotoxicology and environmental safety 2025 Jun 15;298:118333
Ecotoxicology and environmental safety 2025 Jun 15;298:118333
HNF4A promotes tumor progression in gastric cancer by transcriptional activation of KIF2C.
Lu H, Gan JH, Zhou LQ, Yuan YW, Zhou Q, Xin L
Clinical and experimental medicine 2025 Jun 14;25(1):205
Clinical and experimental medicine 2025 Jun 14;25(1):205
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62
Bone research 2025 Jun 12;13(1):62
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.
Zheng M, Yuan G, Han J, Li J, Jiang Y, Li Z, Yao Y
Immunologic research 2025 Jun 11;73(1):94
Immunologic research 2025 Jun 11;73(1):94
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Wei X, Yu C, Wang J
Connective tissue research 2025 Jul;66(4):298-310
Connective tissue research 2025 Jul;66(4):298-310
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
Meng F, Li H, Huang Y, Wang C, Liu Y, Zhang C, Chen D, Zeng T, Zhang S, Li Y, Zhang B, Lang C, Xia J, Xiong W, Pan S, Sun X, Thorne RF, Liu Y, Wang J, Zhang S, Song R, Wang J, Liu L
Nature cancer 2025 Jul;6(7):1223-1241
Nature cancer 2025 Jul;6(7):1223-1241
Mechanistic Insights Into 5'-tiRNA-His-GTG Mediated Activation of the JNK Pathway in Skin Photoaging.
Liu L, Xu Z, Dai X, Zhou X, Chen L, Luan C, Huang D, Chen H, Zhang J, Hu Y, Chen K
Aging cell 2025 Jul;24(7):e70049
Aging cell 2025 Jul;24(7):e70049
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM
Autophagy 2025 Jul;21(7):1433-1455
Autophagy 2025 Jul;21(7):1433-1455
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Ding Y, Wang J, Li J, Cheng Y, Zhou S, Zhang Y, Zhao Y, Zhou M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
FGF13 prevents age-related hearing loss by protecting spiral ganglion neurons and ribbon synapses from injury.
Yin H, Cao H, Yang J, Liu T, Li Q, Liu M, Wang B
Cell death discovery 2025 Jul 5;11(1):307
Cell death discovery 2025 Jul 5;11(1):307
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
Su J, Zhao Y, Li M, Chen G, Liu C, Idris A, Ma Z, Zhang H
Scientific reports 2025 Jul 30;15(1):27850
Scientific reports 2025 Jul 30;15(1):27850
TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H.
Zhang Q, Zhou X, Hao X, Sun Q, Zhang G, Xu S
Translational cancer research 2025 Jul 30;14(7):3905-3919
Translational cancer research 2025 Jul 30;14(7):3905-3919
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Wang Y, Wang C, Zhu Y, Chen K, Yu Y, Li R, Huang S, Tao T, Jiang Y
Journal of ethnopharmacology 2025 Jul 24;351:120042
Journal of ethnopharmacology 2025 Jul 24;351:120042
Injectable thermosensitive hydrogel-encapsulated paclitaxel liposomes enriched with miR-455-3p antagomir for dormancy therapy of salivary adenoid cystic carcinoma.
Li M, Zhang X, Zhang LH, Wang JR, Fan HY, Dou ZC, Liang XH, Tang YL
Journal of materials chemistry. B 2025 Jul 23;13(29):8749-8766
Journal of materials chemistry. B 2025 Jul 23;13(29):8749-8766
C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging.
Le Pelletier L, Ngono Ayissi K, Gorwood J, Capel E, Morichon R, Mantecon M, Auclair M, Alili R, Katlama C, Cuzin L, Atlan M, Beaupère C, Poitou C, Boccara F, Fève B, Capeau J, Lagathu C, Béréziat V
Cardiovascular diabetology 2025 Jul 18;24(1):295
Cardiovascular diabetology 2025 Jul 18;24(1):295
Integrating Multiomics and Machine Learning: Senescence-Regulated ALMS1-IT1/miR-7c-5p/HMGA2 Axis as a Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma.
Zhu Y, Yang Z, Luo Y, Qin L, Ma Y, Zhu J, Wang F, Peng L, Ying K, Qiu T, Xi Z, Wang Y, Sun M
ACS omega 2025 Jul 15;10(27):28821-28835
ACS omega 2025 Jul 15;10(27):28821-28835
Exploring ID4 as a driver of aggression and a therapeutic target in triple-negative breast cancer.
Toro C, Real S, Laurito S, Branham MT
NPJ breast cancer 2025 Jul 10;11(1):69
NPJ breast cancer 2025 Jul 10;11(1):69
E3 ligase TRIM22 promotes melanoma proliferation by regulating cell cycle progression through K63-linked ubiquitination of p21.
Jin CX, Feng TZ, Ji X, Liu YS, Qin HN, Teng YB, Sampson C, Xia T, Piao HL, Liu JW
Scientific reports 2025 Jul 1;15(1):22311
Scientific reports 2025 Jul 1;15(1):22311
CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.
Mei S, Ma X, Zhou L, Wuyun Q, Cai Z, Yan J, Ding H
Cell proliferation 2025 Jan;58(1):e13742
Cell proliferation 2025 Jan;58(1):e13742
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Guo L, Chen W, Yue J, Gao M, Zhang J, Huang Y, Xiong H, Li X, Wang Y, Yuan Y, Chen L, Fei F, Xu R
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.
Shu X, Yi J, Li J, Ying Y, Tang Y, Chen Z, Wang J, Zhang F, Lu D, Wu Y, Sun J, Lin S, Qi Z, Chen D, Wang X, Chen H, Xie L, Ma X, Luo J
Cellular signalling 2025 Jan;125:111510
Cellular signalling 2025 Jan;125:111510
MAFB-mediated CEBPA regulated human urothelium growth through Wnt/β-catenin signaling pathway.
Liu Z, Luo X, Zhang Z, Zhang Q, Wang C, Chen H, Long C, Liu X, Wei G
Genes & diseases 2025 Jan;12(1):101432
Genes & diseases 2025 Jan;12(1):101432
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7.
Xu Y, Chen R, Zhuang Y, Xu W
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251343365
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251343365
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Liu H, Guo Z, Zang Z, Jia B, Zhou Y, Zhang H, Fu Q
Journal of ethnopharmacology 2025 Jan 31;340:119273
Journal of ethnopharmacology 2025 Jan 31;340:119273
Shanyao regulates the PI3K/AKT/P21 pathway to promote oogonial stem cell proliferation and stemness restoration to alleviate premature ovarian insufficiency.
Zou Y, Li Z, Lin Y, Zheng Y, Liu Z, Li Y, Huang L, Chen Z, Zhu L
Journal of ethnopharmacology 2025 Jan 31;340:119168
Journal of ethnopharmacology 2025 Jan 31;340:119168
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.
Cao M, Shao Z, Qian X, Chen M, Deng C, Chen X, Tang T, Zhang K, Chu S, Zheng J, Bai J, Li Z
Cell death & disease 2025 Jan 31;16(1):56
Cell death & disease 2025 Jan 31;16(1):56
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.
Liu M, Chen P, Wei B, Tan HL, Zhao YX, Ai L, Li N, Jiang YK, Lin J, Li SJ, Chang S
Scientific reports 2025 Jan 2;15(1):327
Scientific reports 2025 Jan 2;15(1):327
Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes.
Ding H, Zhang Q, Yang R, Fu L, Jiang H, Zhu Q, Tai S
iScience 2025 Jan 17;28(1):111594
iScience 2025 Jan 17;28(1):111594
Nitazoxanide alleviates experimental pulmonary fibrosis by inhibiting the development of cellular senescence.
Wang X, Zhu Y, Liu H, Wang X, Zhang H, Chen X
Life sciences 2025 Jan 15;361:123302
Life sciences 2025 Jan 15;361:123302
DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.
Zhan Y, Huang Q, Deng Z, Chen S, Yang R, Zhang J, Zhang Y, Peng M, Wu J, Gu Y, Zeng Z, Xie J
Journal of advanced research 2025 Feb;68:201-214
Journal of advanced research 2025 Feb;68:201-214
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway.
Li J, Wang Y, Wei S, Xu S, Dai S, Zhang L, Tian Z, Zhao L, Lv H
Molecular carcinogenesis 2025 Feb;64(2):244-259
Molecular carcinogenesis 2025 Feb;64(2):244-259
The H5N1-NS1 protein affects the host cell cycle and apoptosis through interaction with the host lncRNA PIK3CD-AS2.
Zhang M, Zeng Y, Liu Q, Li F, Zhao J, Liu Z, Liu H, Feng H
Virus genes 2025 Feb;61(1):38-53
Virus genes 2025 Feb;61(1):38-53
Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD(+) acute myeloid leukemia.
Zhou Q, Guan Y, Zhao P, Chu H, Xi Y
Translational oncology 2025 Feb;52:102271
Translational oncology 2025 Feb;52:102271
Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.
Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Cheng Z, Gan W, Xiang Q, Zhao K, Gao H, Chen Y, Shi P, Zhang A, Li G, Song Y, Feng X, Yang C, Zhang Y
Autophagy 2025 Feb;21(2):352-373
Autophagy 2025 Feb;21(2):352-373
Reduced OTUD7B expression correlates with poor prognosis in PTCL via non-canonical NF-κB.
Chen F, Qiu S, Gui A, Jiang S, Yan Y, Wu J, Chen G, Zhu S, Liu Y, Xia Z, Yu B, Sun X, Gu JJ, Wang L, Liu W, Yang L, Zhang Q, Zuo J
International journal of hematology 2025 Feb;121(2):194-205
International journal of hematology 2025 Feb;121(2):194-205
Senescent Fibroblasts Drive FAP/OLN Imbalance Through mTOR Signaling to Exacerbate Inflammation and Bone Resorption in Periodontitis.
Yin C, Fu L, Guo S, Liang Y, Shu T, Shao W, Xia H, Xia T, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409398
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409398
CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy.
Zhang Y, Yang S, You X, Li Z, Chen L, Dai R, Sun H, Zhang L
Stem cell research & therapy 2025 Feb 7;16(1):49
Stem cell research & therapy 2025 Feb 7;16(1):49
PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53.
Fan Y, Li Y, Luo X, Xiang S, Hu J, Zhan J, Chang W, Deng R, Ran X, Zhang Y, Cai Y, Zhu W, Wang H, Liu Z, Wang D
Journal of translational medicine 2025 Feb 4;23(1):157
Journal of translational medicine 2025 Feb 4;23(1):157
Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles.
Li H, Liu Y, Lin Y, Li S, Liu C, Cai A, Li W, Zhang W, Gao X, Ren Z, Ji H, Yu Y, Wang X, Ma W, Wang N, Zhao D, Li T, Liu Y, Cai B
Nature communications 2025 Feb 3;16(1):1292
Nature communications 2025 Feb 3;16(1):1292
Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.
Wu M, Wu B, Huang X, Wang Z, Zhu M, Zhu Y, Yu L, Liu J
Journal of translational medicine 2025 Feb 28;23(1):248
Journal of translational medicine 2025 Feb 28;23(1):248
Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.
Tang X, Zhong J, Luo H, Zhou F, Wang L, Lin S, Xiong J, Lv H, Zhou Z, Yu H, Cao K
Scientific reports 2025 Feb 25;15(1):6780
Scientific reports 2025 Feb 25;15(1):6780
FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L
Communications biology 2025 Feb 24;8(1):299
Communications biology 2025 Feb 24;8(1):299
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
Sheng Q, Yu Q, Lu S, Yang M, Fan X, Su H, Kong Z, Gao Y, Wang R, Lv Z
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
UFMylation maintains YAP stability to promote vascular endothelial cell senescence.
Liu Y, Zuo M, Wu A, Wang Z, Wang S, Bai Y, Zhou J, Wang H
iScience 2025 Feb 21;28(2):111854
iScience 2025 Feb 21;28(2):111854
Luteolin Mitigates Photoaging Caused by UVA-Induced Fibroblast Senescence by Modulating Oxidative Stress Pathways.
Yan Y, Huang H, Su T, Huang W, Wu X, Chen X, Ye S, Zhong J, Li C, Li Y
International journal of molecular sciences 2025 Feb 20;26(5)
International journal of molecular sciences 2025 Feb 20;26(5)
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Hu X, Li J, Ding C, Jiang J, Xia W, Lu J, Su H, Zhang M, Li H, Liu JL, Lin Y, Meng Q, Huang B
Communications biology 2025 Feb 11;8(1):215
Communications biology 2025 Feb 11;8(1):215
Induction of the p21/CDK6 pathway and alteration of the immune microenvironment by the stem cell marker CBX3 in melanoma.
Chen W, Zhou L, Jiang J, Chen J, Geng D, Chen Y, Han X, Xie Q, Guo G, Chen X, Tang S, Zhong X
Stem cell research & therapy 2025 Feb 11;16(1):63
Stem cell research & therapy 2025 Feb 11;16(1):63
Injectable DAT-ALG Hydrogel Mitigates Senescence of Loaded DPMSCs and Boosts Healing of Perianal Fistulas in Crohn's Disease.
Gao H, Xing D, Wu M, Hu Y, He J, Chen S, Zhang G, Yao F, Ma P, Xue W
ACS biomaterials science & engineering 2025 Feb 10;11(2):1171-1183
ACS biomaterials science & engineering 2025 Feb 10;11(2):1171-1183
3D-cultured DFAT spheroid-derived exosomes promote aged wound healing via modulation of the NF-κB/Serpine1 pathway.
Ma X, Wei W, Zeng H, Dong M
Tissue & cell 2025 Dec;97:103049
Tissue & cell 2025 Dec;97:103049
Identification of GBP6 as a potential prognostic biomarker in esophageal carcinoma by integrated bioinformatics analysis and experiment validation.
Fang S, Ding Y, Jia Y, Gao L, Ning Y, Wu G, Fang J, Zhang Y, Wang H, Ke H
Annals of medicine 2025 Dec;57(1):2521451
Annals of medicine 2025 Dec;57(1):2521451
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice.
Zhu Y, Zhang Y, Zhang Q, Song P, Zhang J, Ma A, Wang C, Gao P, Yang T, Zhou L, Shi Q, Wong YK, Luo Y, Tang H, Wang J
Exploration (Beijing, China) 2025 Dec;5(6):20240069
Exploration (Beijing, China) 2025 Dec;5(6):20240069
Fluorescence lifetime clocks quantify senescence and aging.
Yan C, Liu C, Liu B, Zheng Q, Zhao X, Lu S, Fu X, Li W, Li J, Li D, Yao Y, Zhang Y, Zhu H, Shi P, Zhu WH, Guo Z
Nature aging 2025 Dec;5(12):2532-2545
Nature aging 2025 Dec;5(12):2532-2545
Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling.
Wang Q, Liang Y, Zuo Q, He L, Zhang T, Wang Z, Zhai J, Cao B, Ma S, Zhang G, Lu F, Guo Y
Renal failure 2025 Dec;47(1):2546624
Renal failure 2025 Dec;47(1):2546624
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
Shen D, Lin L, Su Y, Xu J, Jiang W, Zhang Z, Fang Y, Ding X, Xu X
Renal failure 2025 Dec;47(1):2499897
Renal failure 2025 Dec;47(1):2499897
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Zhang M, Xiang Y, Li C, Xu C, Chen G, Long R, Chen C, Liu Y, Ye F
Bioorganic chemistry 2025 Dec;167:109186
Bioorganic chemistry 2025 Dec;167:109186
5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging.
Xu Z, Liu L, Dai X, Zhou X, Chen L, Chen H, Luan C, Huang D, Zhang J, Hu Y, Chen K, Gu H
Non-coding RNA research 2025 Dec;15:29-43
Non-coding RNA research 2025 Dec;15:29-43
Epidermal Loss of PRMT5 Leads to the Emergence of an Atypical Basal Keratinocyte-Like Cell Population and Defective Epidermal Stratification.
Recka N, Simons A, Cornell RA, Van Otterloo E
The Journal of investigative dermatology 2025 Dec;145(12):3100-3114.e14
The Journal of investigative dermatology 2025 Dec;145(12):3100-3114.e14
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis.
Li Z, Sun X, Wang Y, Zhang F, Wang L, Ai C, Zhang X, Yin X, Liu C, Li C, Lu C
Basic research in cardiology 2025 Dec;120(6):1225-1247
Basic research in cardiology 2025 Dec;120(6):1225-1247
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
Zhang C, Du Y, Ji Y, Ye X, Lian J, Zhou H, Gao Z, Xu H, Tang Y, Fan Y, Zheng L
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
EXOSC3 knockdown induces G1/S phase arrest to suppress hepatocellular carcinoma cell proliferation.
Chen YM, Huo YX, Wei WS, Liu YX, Wang SH, Jiang L, Rong-He, Zhang HL, Jiang LH
Scientific reports 2025 Dec 29;15(1):44684
Scientific reports 2025 Dec 29;15(1):44684
ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms.
Lewis C, Levis H, Holbrook J, Polaski JT, Jacobsen TD, Mizels J, Gullbrand SE, Diekman B, Iatridis JC, Gertz J, Lawrence B, Bowles RD
bioRxiv : the preprint server for biology 2025 Dec 25;
bioRxiv : the preprint server for biology 2025 Dec 25;
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
Wang HG, Lu MX, Sheng ML, Lou YB, Xiao YC, Guo A, Yu ZH
Scientific reports 2025 Dec 24;15(1):44516
Scientific reports 2025 Dec 24;15(1):44516
Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
Mecca M, Sichetti M, Spina E, Giuseffi M, Giglio E, Picerno S, Valvano L, Statuto T, Santarsiere A, Funicello M, Armentano MF, Chiummiento L, Lupattelli P, Romano A, Giordano A, Cortellino S
Cancer cell international 2025 Dec 23;26(1):44
Cancer cell international 2025 Dec 23;26(1):44
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
Han L, Zhai H, Ma X, Li H, Ren Q, Liu J, Zhang Z, Li X, Zhang Q, Sun X
Current issues in molecular biology 2025 Dec 20;48(1)
Current issues in molecular biology 2025 Dec 20;48(1)
WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.
Chen X, Wang J, Yan Z, Du X, Zhang Z, Liu X, Hu L, He K, Zhang J, Han Y
Cell death & disease 2025 Dec 12;17(1):96
Cell death & disease 2025 Dec 12;17(1):96
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Zhang Q, Cao S, Zhang M, Wu D, Zhang C, Li J
International dental journal 2025 Aug;75(4):100819
International dental journal 2025 Aug;75(4):100819
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
Kuang B, Geng N, Yi M, Zeng Q, Fan M, Xian M, Deng L, Chen C, Pan Y, Kuang L, Luo F, Xie Y, Liu C, Deng Z, Nie M, Du Y, Guo F
Journal of advanced research 2025 Aug;74:493-511
Journal of advanced research 2025 Aug;74:493-511
The lncRNA ST18-AS1 suppresses pancreatic cancer progression by enhancing ST18 mRNA stability through anchoring FUS in the cytoplasm.
Cheng L, Yu H, Qin Y, Wang R, Su T, Lyu G, Huang Z, Li H, Jin Y, Li Y, Wang G
Oncogene 2025 Aug;44(32):2850-2863
Oncogene 2025 Aug;44(32):2850-2863
Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells.
Tseng CC, Ku MH, Wu WM, Mendez A, Christner T, Wu YC, Huang WL, Chen YH, Huang CW, Barefoot J, Chen CW
Investigational new drugs 2025 Aug;43(4):857-873
Investigational new drugs 2025 Aug;43(4):857-873
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
Yang S, Sun Y, Luo W, Zhou X, Gu X, Zhang W, Zhu H, Wu W, Wu X, Yu M, Wang S
Materials today. Bio 2025 Aug;33:101930
Materials today. Bio 2025 Aug;33:101930
The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth.
Xie Z, Li C, Huang R, Wu B, Huang Q, Zhang Z, Zhao T, Wu L, Li C, Shen J, Wang H
Cell death and differentiation 2025 Aug;32(8):1428-1440
Cell death and differentiation 2025 Aug;32(8):1428-1440
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
Wei D, Zhang H, Xu W, Zhang B, Zhang L, Lan L, Li Y, Shi Y, Song X
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy.
Ding R, Huang W, Shen C, Pan Y, Zhong Y, Kong B, Shen Y, Xiang M, Ye B
Aging cell 2025 Aug;24(8):e70099
Aging cell 2025 Aug;24(8):e70099
CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.
Wang Y, Chang F, Li Z, Duan C, Sun X, Wang S, Wei D, Li W, Qian Y, Cao S, Zhao J, Lei D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e14961
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e14961
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation.
Zhang X, Liang H, Liao Z, Tong B, Wu D, Ma L, Lei J, Zhou X, Zhu D, Ou Z, Wei J, Tan L, Yang C
Science advances 2025 Aug 8;11(32):eadu6860
Science advances 2025 Aug 8;11(32):eadu6860
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
Xiong L, Shu J, Gao H, Qin Y, Zhang Y, Chang X, Dong Q, Chen H
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
CD81(+) senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.
Fu L, Yin C, Zhao Q, Guo S, Shao W, Xia T, Sun Q, Chen L, Li J, Wang M, Xia H
eLife 2025 Aug 13;13
eLife 2025 Aug 13;13
Overexpression of FOS enhances the malignant potential of eutopic endometrial stromal cells in patients with endometriosis‑associated ovarian cancer.
Chen J, He K, Li X, Wang M, Yang Z, Wang Z, Wang K, Jiang W, Zhao L, Cui M
Oncology reports 2025 Apr;53(4)
Oncology reports 2025 Apr;53(4)
Integrative analysis of genetic variability and functional traits in lung adenocarcinoma epithelial cells via single-cell RNA sequencing, GWAS, bayesian deconvolution, and machine learning.
Gao C, Wu J, Zhong F, Yang X, Liu H, Lai J, Cai J, Mao W, Xu H
Genes & genomics 2025 Apr;47(4):435-468
Genes & genomics 2025 Apr;47(4):435-468
Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma.
Zeng W, Liu F, Liu Y, Zhang Z, Hu H, Ning S, Zhang H, Chen X, Liao Z, Zhang Z
Clinical and molecular hepatology 2025 Apr;31(2):489-508
Clinical and molecular hepatology 2025 Apr;31(2):489-508
Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging.
Xu X, Lu X, Chen X, Yao A, Lai W
Journal of cosmetic dermatology 2025 Apr;24(4):e70098
Journal of cosmetic dermatology 2025 Apr;24(4):e70098
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice.
He X, Wang C, Zhang Q, Yang T, Guo Q, Wang Y, Guo J, Wang P, Zhang J, Tang H, Zhu Y, Wang J
Aging cell 2025 Apr;24(4):e14433
Aging cell 2025 Apr;24(4):e14433
Development and Validation of a Prognostic Model for Lung Adenocarcinoma Based on CAF-Related Genes: Unveiling the Role of COX6A1 in Cancer Progression and CAF Infiltration.
Zhu X, Li B, Qin L, Liang T, Hu W, Li J, Wang J
International journal of molecular sciences 2025 Apr 8;26(8)
International journal of molecular sciences 2025 Apr 8;26(8)
Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma.
Cakiroglu E, Eris S, Oz O, Karakülah G, Senturk S
Cell death & disease 2025 Apr 3;16(1):241
Cell death & disease 2025 Apr 3;16(1):241
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
Cao C, Xu W, Lei J, Zheng Y, Zhang A, Xu A, Lin F, Zhou M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug.
Shi W, Lin H, Di W, He C, Shen Y
Reproductive biology and endocrinology : RB&E 2025 Apr 26;23(1):61
Reproductive biology and endocrinology : RB&E 2025 Apr 26;23(1):61
Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice.
Umeda T, Sakai A, Uekado R, Shigemori K, Nakajima R, Yamana K, Tomiyama T
eLife 2025 Apr 23;13
eLife 2025 Apr 23;13
PRC1 promotes ovarian cancer progression by binding to RPL4 and increasing MDM2-mediated p53 ubiquitination.
Xu Y, Xu J, Xu K, Zhang C, Wang F, Zhang R, Zhu P
Experimental cell research 2025 Apr 15;447(2):114509
Experimental cell research 2025 Apr 15;447(2):114509
Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease.
Zhu F, Lin BR, Lin SH, Yu CH, Yang YM
World journal of gastroenterology 2025 Apr 14;31(14):104117
World journal of gastroenterology 2025 Apr 14;31(14):104117
Conditional Overexpression of Neuritin in Supporting Cell Protects Cochlear Hair Cell and Delays Age-Related Hearing Loss by Enhancing Autophagy.
Wang S, Lv S, Hu J, Shi Y, Li Y, Zhang J, Tan X, Chen R, Hong Y
International journal of molecular sciences 2025 Apr 14;26(8)
International journal of molecular sciences 2025 Apr 14;26(8)
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Gou P, Fang C, Xu M, Zhang D, Wu X, Zhang L, Li X, Li M, Gan L, Luo J, Cui H, Liang P
Cell death discovery 2025 Apr 14;11(1):172
Cell death discovery 2025 Apr 14;11(1):172
Inhibition of AGTR1 attenuates cell proliferation after glaucoma filtration surgery via NF-κB pathway-mediated G(0)/G(1)-phase cell cycle arrest.
Wang L, Wang W, Sun C, Li T, Wang J
Experimental cell research 2025 Apr 1;447(1):114514
Experimental cell research 2025 Apr 1;447(1):114514
BANP Participates in the Chronic Intermittent Hypoxia-Induced Senescence of Vascular Endothelial Cells by Promoting P53 Phosphorylation and Nuclear Retention.
Li X, Zhao C, Liu W, Zhu Q, Mu L, Ma C
Gerontology 2024;70(3):302-317
Gerontology 2024;70(3):302-317
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Gao XF, Ji BY, Zhang JJ, Wang Z, Jiang S, Hu JN, Gong XJ, Zhang JT, Tsopmejio ISN, Li W
The American journal of Chinese medicine 2024;52(5):1427-1449
The American journal of Chinese medicine 2024;52(5):1427-1449
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB.
Han W, Gu D, Li X, Chen H, Tao X, Chen L
Tissue engineering. Part C, Methods 2024;30(6):248-254
Tissue engineering. Part C, Methods 2024;30(6):248-254
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System.
Wang K, Zhu Y, Li M, Yang Y, Zuo D, Sheng J, Zhang X, Wang W, Zhou P, Feng M
Biomaterials research 2024;28:0043
Biomaterials research 2024;28:0043
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Liu X, Zhao W, Hu M, Zhang Y, Wang J, Zhang L
Iranian journal of basic medical sciences 2024;27(5):588-595
Iranian journal of basic medical sciences 2024;27(5):588-595
Ursolic Acid Alleviates Mitotic Catastrophe in Podocyte by Inhibiting Autophagic P62 Accumulation in Diabetic Nephropathy.
Mei H, Jing T, Liu H, Liu Y, Zhu X, Wang J, Xu L
International journal of biological sciences 2024;20(9):3317-3333
International journal of biological sciences 2024;20(9):3317-3333
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926
International journal of biological sciences 2024;20(5):1905-1926
CENPW knockdown inhibits progression of bladder cancer through inducing cell cycle arrest and apoptosis.
Zhang P, Yang Q, Chen X, Chen X, Wang Q, Chen K, An Y, Jiang K, Sun F
Journal of Cancer 2024;15(3):858-870
Journal of Cancer 2024;15(3):858-870
IPCEF1: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma.
Yin D, Wang K, Zhao J, Yao J, Han X, Yan B, Dong J, Liao L
Journal of Cancer 2024;15(19):6434-6451
Journal of Cancer 2024;15(19):6434-6451
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Wang M, Zhang H, Lu Z, Su W, Tan Y, Wang J, Jia X
Journal of Cancer 2024;15(10):3183-3198
Journal of Cancer 2024;15(10):3183-3198
Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence.
Qin L, Liang T, Zhang H, Gong X, Wei M, Song X, Hu Y, Zhu X, Hu W, Li J, Wang J
Frontiers in immunology 2024;15:1512445
Frontiers in immunology 2024;15:1512445
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
Ke J, Zang H, Liu Y, Teng Q, Hua J, Peng D, Wang P
Frontiers in pharmacology 2024;15:1480629
Frontiers in pharmacology 2024;15:1480629
MDM2 inhibitor APG-115 synergizes with ABT-199 to induce cell apoptosis in chronic lymphocytic leukemia.
Cui Y, Shao X, Yang H, Xin J, Liu Y, Zhang M, Sun C, Chen G, Shen G, Meng X, Chen Y
Frontiers in pharmacology 2024;15:1441383
Frontiers in pharmacology 2024;15:1441383
Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence.
Jo M, Kim S, Park J, Chang YT, Gwon Y
Redox biology 2024 Sep;75:103279
Redox biology 2024 Sep;75:103279
14-3-3σ/Stratifin and p21 limit AKT-related malignant progression in skin carcinogenesis following MDM2-associated p53 loss.
McMenemy CM, Guo D, Quinn JA, Greenhalgh DA
Molecular carcinogenesis 2024 Sep;63(9):1768-1782
Molecular carcinogenesis 2024 Sep;63(9):1768-1782
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
Zheng ZH, Wang JJ, Lin JG, Ye WL, Zou JM, Liang LY, Yang PL, Qiu WL, Li YY, Yang SJ, Zhao M, Zhou Q, Li CZ, Li M, Li ZM, Zhang DM, Liu PQ, Liu ZP
Acta pharmacologica Sinica 2024 Sep;45(9):1879-1897
Acta pharmacologica Sinica 2024 Sep;45(9):1879-1897
Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.
Yu J, Zhang M, Li T, Gao W, Yang Z, Wang K, Liu Z, Zhu S, Wen S, Zhao Y, Cai Q, Shang Z, Wang Y, Niu Y
Oncogene 2024 Sep;43(38):2835-2849
Oncogene 2024 Sep;43(38):2835-2849
Ubiquitination of p21 by E3 ligase RNF135 promotes the proliferation of human glioblastoma cells.
Gu W, Wang M, Wu Z, Cai Y
Oncology letters 2024 Sep;28(3):406
Oncology letters 2024 Sep;28(3):406
Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p/CDK2AP2 axis in non-small cell lung cancer.
Liu R, Zhang H, Xin J, Xie SY, Jiao F, Li YJ, Chu MY, Qiu J, Yan YF
Thoracic cancer 2024 Sep;15(27):1929-1945
Thoracic cancer 2024 Sep;15(27):1929-1945
Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1).
Ma N, Zhang M, Hu J, Wei Z, Zhang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155876
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155876
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Zhang M, Li L, Zhang W, Li M, Yan G, Tang C
Cellular signalling 2024 Sep;121:111296
Cellular signalling 2024 Sep;121:111296
Mitochondrial dysfunction-associated alveolar epithelial senescence is involved in CdCl(2)-induced COPD-like lung injury.
Peng K, Yao YX, Lu X, Wang WJ, Zhang YH, Zhao H, Wang H, Xu DX, Tan ZX
Journal of hazardous materials 2024 Sep 5;476:135103
Journal of hazardous materials 2024 Sep 5;476:135103
YIPF2 regulates genome integrity.
Zhang X, Wang T
Cell & bioscience 2024 Sep 5;14(1):114
Cell & bioscience 2024 Sep 5;14(1):114
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Geng N, Fan M, Kuang B, Zhang F, Xian M, Deng L, Chen C, Pan Y, Chen J, Feng N, Liang L, Ye Y, Liu K, Li X, Du Y, Guo F
Nature communications 2024 Sep 4;15(1):7712
Nature communications 2024 Sep 4;15(1):7712
Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.
Li P, Hu X, Fan Z, Sun S, Ran Q, Wei T, Wei P, Jiang Q, Yan J, Yang N, Jia C, Yang T, Mao Y, Cai X, Xu T, Zhao Z, Qian X, Qin W, Zhuang X, Fan F, Xiao J, Zheng Z, Li S
Journal of hematology & oncology 2024 Sep 2;17(1):77
Journal of hematology & oncology 2024 Sep 2;17(1):77
Asparagine Dependency Is a Targetable Metabolic Vulnerability in TP53-Altered Castration-Resistant Prostate Cancer.
Yoo YA, Quan S, Yang W, Guo Q, Rodríguez Y, Chalmers ZR, Dufficy MF, Lackie B, Sagar V, Unno K, Truica MI, Chandel NS, Abdulkadir SA
Cancer research 2024 Sep 16;84(18):3004-3022
Cancer research 2024 Sep 16;84(18):3004-3022
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
Hu Z, Wu Y, Sun X, Tong Y, Qiu H, Zhuo E
Biology direct 2024 Sep 16;19(1):82
Biology direct 2024 Sep 16;19(1):82
Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries.
Wang H, Zeng P, Zhu PH, Wang ZF, Cai YJ, Deng CY, Yang H, Mai LP, Zhang MZ, Kuang SJ, Rao F, Xu JS
European journal of pharmacology 2024 Sep 15;979:176832
European journal of pharmacology 2024 Sep 15;979:176832
Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K-AKT and apoptosis pathways.
Xu Z, Zhang Z, Zhou H, Lin S, Gong B, Li Z, Zhao S, Hou Y, Peng Y, Bian Y
Journal of cellular and molecular medicine 2024 Oct;28(20):e70161
Journal of cellular and molecular medicine 2024 Oct;28(20):e70161
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Li T, Liu Y, Cao J, Pan C, Ding R, Zhao J, Liu J, He D, Jia J, Cheng X
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress.
Chen Q, Hu R, Qiu H, Li S, Xiang P, Lu Y, Wang X, Wang T, Zhou L, Zhang W, Wen E, Ma L, Yu C
Mechanisms of ageing and development 2024 Oct;221:111962
Mechanisms of ageing and development 2024 Oct;221:111962
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Peng S, Liu X, Chang L, Liu B, Zhang M, Mao Y, Shen X
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Cdk1/p53/p21 feedback loop mechanisms in the pathogenesis of interstitial cystitis/bladder pain syndrome.
Wang K, Shi J, Chen Z, Xue D, He X
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167305
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167305
Hsa-miR-3928-3p targets the CCL3/CCR5 axis to induce amniotic epithelial cell senescence involved in labor initiation.
Liu Q, Jing D, Li Y, Yao B, Zhang H, Wang L, Wu C, Wang X, Li L
Placenta 2024 Oct;156:98-107
Placenta 2024 Oct;156:98-107
SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling.
Cui YZ, Xu F, Zhou Y, Wang ZY, Yang XY, Fu NC, Chen XB, Zheng YX, Chen XY, Ye LR, Li YY, Man XY
The Journal of investigative dermatology 2024 Oct;144(10):2255-2266.e4
The Journal of investigative dermatology 2024 Oct;144(10):2255-2266.e4
Identification and biological evaluation of fused tetrahydroisoquinoline derivatives as Wnt/β-catenin signaling inhibitors to suppress colorectal cancer.
Zhou J, Xu B, Shen Q, Zhang Z, Hu Y, Wang M, Su Y, Lei Z, Zhang W, Liu T, Liu H, Hu T, Zhou Y
European journal of medicinal chemistry 2024 Oct 5;276:116664
European journal of medicinal chemistry 2024 Oct 5;276:116664
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Zhang H, Xiao X, Wang L, Shi X, Fu N, Wang S, Zhao RC
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Zuogui Pills alleviate cyclophosphamide-induced ovarian aging by reducing oxidative stress and restoring the stemness of oogonial stem cells through the Nrf2/HO-1 signaling pathway.
Li Z, Liang Y, Wang Y, Lin Y, Zeng L, Zhang Y, Zhu L
Journal of ethnopharmacology 2024 Oct 28;333:118505
Journal of ethnopharmacology 2024 Oct 28;333:118505
Characterization of PANoptosis-related genes with immunoregulatory features in osteoarthritis.
Lan Z, Yang Y, Sun R, Lin X, Yan J, Chen X, Tian K, Wu G, Saad M, Wu Z, Xue D, Jin Q
International immunopharmacology 2024 Oct 25;140:112889
International immunopharmacology 2024 Oct 25;140:112889
Sulforaphane Promotes Proliferation of Porcine Granulosa Cells via the H3K27ac-Mediated GDF8-ALK5-ERK Pathway.
Zhou J, Fu C, Shen M, Tao J, Liu H
Journal of agricultural and food chemistry 2024 Oct 2;72(39):21635-21649
Journal of agricultural and food chemistry 2024 Oct 2;72(39):21635-21649
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy.
Chhabra Y, Fane ME, Pramod S, Hüser L, Zabransky DJ, Wang V, Dixit A, Zhao R, Kumah E, Brezka ML, Truskowski K, Nandi A, Marino-Bravante GE, Carey AE, Gour N, Maranto DA, Rocha MR, Harper EI, Ruiz J, Lipson EJ, Jaffee EM, Bibee K, Sunshine JC, Ji H, Weeraratna AT
Cell 2024 Oct 17;187(21):6016-6034.e25
Cell 2024 Oct 17;187(21):6016-6034.e25
SIRT1-mediated tunnelling nanotubes may be a potential intervention target for arsenic-induced hepatocyte senescence and liver damage.
Wang Q, Zhu K, Zhang A
The Science of the total environment 2024 Oct 15;947:174502
The Science of the total environment 2024 Oct 15;947:174502
Discovery of Potent Covalent CRM1 Inhibitors Via a Customized Structure-Based Virtual Screening Pipeline and Bioassays.
Liu H, Shen C, Li H, Hou T, Yang Y
Journal of chemical information and modeling 2024 Oct 14;64(19):7422-7431
Journal of chemical information and modeling 2024 Oct 14;64(19):7422-7431
Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells.
Romani A, Lodi G, Casciano F, Gonelli A, Secchiero P, Zauli G, Bortolini O, Valacchi G, Ragno D, Bondi A, Benedusi M, Esposito E, Voltan R
Cells 2024 Oct 11;13(20)
Cells 2024 Oct 11;13(20)
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
Wu H, Sun C, Cao W, Teng Q, Ma X, Schiöth HB, Dong R, Zhang Q, Kong B
Cancer letters 2024 Oct 10;602:217192
Cancer letters 2024 Oct 10;602:217192
Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 Inflammasome.
Ou C, Lin Y, Wen J, Zhang H, Xu Y, Zhang N, Liu Q, Wu Y, Xu J, Wu J
Investigative ophthalmology & visual science 2024 Oct 1;65(12):38
Investigative ophthalmology & visual science 2024 Oct 1;65(12):38
Leptin promotes tendon stem/progenitor cell senescence through the AKT-mTOR signaling pathway.
Lei C, Li Y, Chen J, Nie D, Song X, Lei C, Zhou Y, Wang W, Sun J
Experimental cell research 2024 Oct 1;442(2):114274
Experimental cell research 2024 Oct 1;442(2):114274
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.
Xiang HL, Yuan Q, Zeng JY, Xu ZY, Zhang HZ, Huang J, Song AN, Xiong J, Zhang C
Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338
Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338
Naringin Induces ROS-Stimulated G(1) Cell-Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Cells.
Chen CH, Tien N, Yao CH, Chen SJ, Bau DT, Pandey S, Yang HL, Hseu YC, Chen SS, Lin ML
Environmental toxicology 2024 Nov;39(11):5059-5073
Environmental toxicology 2024 Nov;39(11):5059-5073
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.
Chen C, Wang X, Fang W, Liang J, Cai J, Yang D, Luo X, Gao C, Yi X, Liu Y, Zhou X
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis.
Liu Y, Chen L, Wang J, Bao X, Huang J, Qiu Y, Wang T, Yu H
British journal of pharmacology 2024 Nov;181(21):4348-4368
British journal of pharmacology 2024 Nov;181(21):4348-4368
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Zhu J, Lin Y, Li G, He Y, Su Z, Tang Y, Zhang Y, Xu Q, Yao Z, Zhou H, Liu B, Cai X
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway.
Gao N, Gao X, Du M, Xiang Y, Zuo H, Huang R, Wan W, Hu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155982
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155982
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Huang G, Zhang J, Xu Y, Wu F, Fu Y, Zhang X, Yin H, You Y, Zhao P, Liu W, Shen J, Yin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3.
Xie C, Zhou X, Wu J, Chen W, Ren D, Zhong C, Meng Z, Shi Y, Zhu J
Cell death & disease 2024 Nov 5;15(11):792
Cell death & disease 2024 Nov 5;15(11):792
PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging.
Zhao H, Zhang Y, Ren Y, Wang W
Investigative ophthalmology & visual science 2024 Nov 4;65(13):12
Investigative ophthalmology & visual science 2024 Nov 4;65(13):12
Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress.
Zhao H, Cao N, Liu Q, Zhang Y, Jin R, Lai H, Zheng L, Zhang H, Zhu Y, Ma Y, Yang Z, Wu Z, Li W, Liu Y, Cheng L, Chen Y
Journal of translational medicine 2024 Nov 28;22(1):1080
Journal of translational medicine 2024 Nov 28;22(1):1080
A single-cell transcriptomic census of mammalian olfactory epithelium aging.
Li W, Wu T, Zhu K, Ba G, Liu J, Zhou P, Li S, Wang L, Liu H, Ren W, Yu H, Yu Y
Developmental cell 2024 Nov 18;59(22):3043-3058.e8
Developmental cell 2024 Nov 18;59(22):3043-3058.e8
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Wang R, Yang X, Wang L, Wang R, Zhang W, Ji Y, Li Z, Li H, Cui L
European journal of pharmacology 2024 Nov 15;983:176959
European journal of pharmacology 2024 Nov 15;983:176959
Vitamin C ameliorates D-galactose-induced senescence in HEI-OC1 cells by inhibiting the ROS/NF-κB pathway.
Xu B, Wang G, Xu L, Ding L, Li S, Han Y
Molecular biology reports 2024 Nov 15;51(1):1157
Molecular biology reports 2024 Nov 15;51(1):1157
LINC00470 promotes malignant progression of testicular germ cell tumors.
Liu Z, Lv S, Qin Z, Shu J, Zhu F, Luo Y, Fan L, Chen M, Bo H, Liu L
Molecular biology reports 2024 Nov 14;51(1):1152
Molecular biology reports 2024 Nov 14;51(1):1152
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis.
Chen L, Chen D, Pan Y, Mo Y, Lai B, Chen H, Zhang DW, Xia XD
Cell death & disease 2024 Nov 1;15(11):786
Cell death & disease 2024 Nov 1;15(11):786
SIRT6-mediated vascular smooth muscle cells senescence participates in the pathogenesis of abdominal aortic aneurysm.
Yang L, Wu X, Bian S, Zhao D, Fang S, Yuan H
Atherosclerosis 2024 May;392:117483
Atherosclerosis 2024 May;392:117483
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Duan L, Hao Z, Ji R, Li X, Wang H, Su Y, Guan F, Ma S
International journal of biological macromolecules 2024 May;268(Pt 1):131739
International journal of biological macromolecules 2024 May;268(Pt 1):131739
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H, Chen K
Aging cell 2024 May;23(5):e14123
Aging cell 2024 May;23(5):e14123
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation.
Wang Y, Wei T, Zhao M, Huang A, Sun F, Chen L, Lin R, Xie Y, Zhang M, Xu S, Sun Z, Hong L, Wang R, Tian R, Li G
PLoS biology 2024 May;22(5):e3002550
PLoS biology 2024 May;22(5):e3002550
Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2.
Jiang F, Xu Y, Jiang Z, Hu B, Lv Q, Wang Z
Cellular signalling 2024 May;117:111073
Cellular signalling 2024 May;117:111073
An integrated multi-omics analysis reveals osteokines involved in global regulation.
Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D, Zou Z, Bai X
Cell metabolism 2024 May 7;36(5):1144-1163.e7
Cell metabolism 2024 May 7;36(5):1144-1163.e7
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
Zeng Q, Luo Y, Sang X, Liao M, Wen B, Hu Z, Sun M, Luo Z, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
ABI3BP promotes renal aging through Klotho-mediated ferroptosis.
Ji R, Wei L, Zan Y, Li X, Ma S, Ma L, He X, Wang L, Ding Y
Journal of translational medicine 2024 May 29;22(1):514
Journal of translational medicine 2024 May 29;22(1):514
Pectinose induces cell cycle arrest in luminal A and triple-negative breast cancer cells by promoting autophagy through activation of the p38 MAPK signaling pathway.
Yu S, Yue Z, Liu Q
BMC cancer 2024 May 24;24(1):639
BMC cancer 2024 May 24;24(1):639
SVHRSP Alleviates Age-Related Cognitive Deficiency by Reducing Oxidative Stress and Neuroinflammation.
Wang Y, Wang Z, Guo S, Li Q, Kong Y, Sui A, Ma J, Lu L, Zhao J, Li S
Antioxidants (Basel, Switzerland) 2024 May 21;13(6)
Antioxidants (Basel, Switzerland) 2024 May 21;13(6)
D-arabinose induces cell cycle arrest by promoting autophagy via p38 MAPK signaling pathway in breast cancer.
Tang Z, Song H, Qin S, Tian Z, Zhang C, Zhou Y, Cai R, Zhu Y
Scientific reports 2024 May 16;14(1):11219
Scientific reports 2024 May 16;14(1):11219
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis.
Ren S, Li C, Xiong H, Wu Q, Wu X, Xiong Z, Dong L, Shu B, Wei W, Ma C, Li X, Chen J
Stem cells translational medicine 2024 May 14;13(5):462-476
Stem cells translational medicine 2024 May 14;13(5):462-476
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Yang M, Gao L, Gao Y, Hao Z, Zhou X, Su G, Bai C, Wei Z, Liu X, Yang L, Li G
International journal of molecular sciences 2024 May 12;25(10)
International journal of molecular sciences 2024 May 12;25(10)
Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping.
Hao DJ, Qin Y, Zhou SJ, Dong BH, Yang JS, Zou P, Wang LP, Zhao YT
Journal of pharmaceutical analysis 2024 Mar;14(3):335-347
Journal of pharmaceutical analysis 2024 Mar;14(3):335-347
Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia.
Ye X, Wang Y, Tian Y, Bi R, Li M, Yang C, Zhang L, Gao Y
Heliyon 2024 Mar 30;10(6):e27478
Heliyon 2024 Mar 30;10(6):e27478
Mechanisms of PM(10) Disruption of the Nrf2 Pathway in Cornea.
Somayajulu M, Muhammed FS, Wright R, McClellan SA, Hazlett LD
International journal of molecular sciences 2024 Mar 28;25(7)
International journal of molecular sciences 2024 Mar 28;25(7)
Serine Metabolism Regulates the Replicative Senescence of Human Dental Pulp Cells through Histone Methylation.
Zhou S, Cui J, Shi Y
Current issues in molecular biology 2024 Mar 24;46(4):2856-2870
Current issues in molecular biology 2024 Mar 24;46(4):2856-2870
Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia.
Li F, Miao J, Liu R, Zhang R, He A
Journal of cancer research and clinical oncology 2024 Mar 20;150(3):144
Journal of cancer research and clinical oncology 2024 Mar 20;150(3):144
DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma.
Chen Y, Gao F, He Y, Liu M, Quan Y, Zhang P
iScience 2024 Mar 15;27(3):109181
iScience 2024 Mar 15;27(3):109181
Cyclin-dependent kinase inhibitor 1A inhibits pyroptosis to enhance human lung adenocarcinoma cell radioresistance by promoting DNA repair.
Li J, Liu T, Tang N, Lin S, Zhang F, Yuan W, Zhang T, Deng SH, Wu DM, Xu Y
Heliyon 2024 Mar 15;10(5):e26975
Heliyon 2024 Mar 15;10(5):e26975
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Cen Q, Chen J, Guo J, Chen M, Wang H, Wu S, Zhang H, Xie X, Li Y
Journal of translational medicine 2024 Mar 14;22(1):278
Journal of translational medicine 2024 Mar 14;22(1):278
Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis.
Zhang Z, Zhao Q, Wang Z, Xu F, Liu Y, Guo Y, Li C, Liu T, Zhao Y, Tang X, Zhang J
Hepatology communications 2024 Mar 1;8(3)
Hepatology communications 2024 Mar 1;8(3)
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Ci M, Zhao G, Li C, Liu R, Hu X, Pan J, Shen Y, Zhang G, Li Y, Zhang L, Liang P, Cui H
Cell death & disease 2024 Mar 1;15(3):179
Cell death & disease 2024 Mar 1;15(3):179
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.
Zhou C, Li D, He J, Luo T, Liu Y, Xue Y, Huang J, Zheng L, Li J
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)
Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia.
Welch N, Mishra S, Bellar A, Kannan P, Gopan A, Goudarzi M, King J, Luknis M, Musich R, Agrawal V, Bena J, Koch CJ, Li L, Willard B, Shah YM, Dasarathy S
The Journal of physiology 2024 Jun;602(12):2763-2806
The Journal of physiology 2024 Jun;602(12):2763-2806
Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy.
Lin JJ, Chen R, Yang LY, Gong M, Du MY, Mu SQ, Jiang ZA, Li HH, Yang Y, Wang XH, Wang SF, Liu KX, Cao SH, Wang ZY, Zhao AQ, Yang SY, Li C, Sun SG
Journal of advanced research 2024 Jun;60:93-110
Journal of advanced research 2024 Jun;60:93-110
Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade.
Zhu K, Ma X, Guan X, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R
Journal of molecular histology 2024 Jun;55(3):241-251
Journal of molecular histology 2024 Jun;55(3):241-251
MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non-small cell lung cancer.
Chen J, Yang J, Liu Y, Zhao X, Zhao J, Tang L, Guo M, Zhou Y, Chen C, Li D, Wen Z, Liang G, Xu L
Cancer innovation 2024 Jun;3(3):e117
Cancer innovation 2024 Jun;3(3):e117
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Qi W, Jin L, Huang S, Aikebaier A, Xue S, Wang Q, Chen Q, Lu Y, Ding C
Acta biomaterialia 2024 Jun;181:425-439
Acta biomaterialia 2024 Jun;181:425-439
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.
Zhang H, Li Q, Guo X, Wu H, Hu C, Liu G, Yu T, Hu X, Qiu Q, Guo G, She J, Chen Y
Journal of pharmaceutical analysis 2024 Jun;14(6):100950
Journal of pharmaceutical analysis 2024 Jun;14(6):100950
Deoxynivalenol induces m(6)A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro.
Xu P, Zhao Y, Feng Y, Zhao M, Zhao R
Cell biology and toxicology 2024 Jun 4;40(1):41
Cell biology and toxicology 2024 Jun 4;40(1):41
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis.
Zhang C, Li W, Liu L, Li M, Sun H, Zhang C, Zhong L, Huang J, Li T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23735
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23735
CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.
Zhong C, Jiang WJ, Yao Y, Li Z, Li Y, Wang S, Wang X, Zhu W, Wu S, Wang J, Fan S, Ma S, Liu Y, Zhang H, Zhao W, Zhao L, Feng Y, Li Z, Guo R, Yu L, Pei F, Hu J, Feng X, Yang Z, Yang Z, Yang X, Hou Y, Zhang D, Xu D, Sheng R, Li Y, Liu L, Wu HJ, Huang J, Fei T
Nature communications 2024 Jun 29;15(1):5502
Nature communications 2024 Jun 29;15(1):5502
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
He B, Zeng Q, Tian Y, Luo Y, Liao M, Huang W, Wu B, Luo Z, Huang X, Liu W, Tang S
Biomedicines 2024 Jun 27;12(7)
Biomedicines 2024 Jun 27;12(7)
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium.
Easter M, Hirsch MJ, Harris E, Howze PH 4th, Matthews EL, Jones LI, Bollenbecker S, Vang S, Tyrrell DJ, Sanders YY, Birket SE, Barnes JW, Krick S
JCI insight 2024 Jun 25;9(15)
JCI insight 2024 Jun 25;9(15)
The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress.
Liu J, Cao L, Wang Y, Zou Y, Guo Q, Chen S, Jiang B, Wu X, Zheng L, Zhang S, Lu S, Zhou K, Jiang P, Xiao Y, Yang R, Dong S, Li Z, Chen D, Zhang Y, Zhang N, Sun G, Xing C, Song X, Wang Z, Cao L
Cell reports 2024 Jun 25;43(6):114366
Cell reports 2024 Jun 25;43(6):114366
The molecular mechanism of action for the potent antitumor component extracted using supercritical fluid extraction from Croton crassifolius root.
Guo X, Zhang RR, Sun JY, Liu Y, Yuan XS, Chen YY, Sun H, Liu C
Journal of ethnopharmacology 2024 Jun 12;327:117835
Journal of ethnopharmacology 2024 Jun 12;327:117835
Tissue-resident C1q + macrophages exert anti-aging potential through the Sirt1 pathway.
Liu L, Zhu L, Liang Q, Yu L, Hu L, Yu Y, Cheng X, Bao H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1069-1080
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jul;73(7):1069-1080
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
Geng N, Xian M, Deng L, Kuang B, Pan Y, Liu K, Ye Y, Fan M, Bai Z, Guo F
Journal of orthopaedic translation 2024 Jul;47:50-62
Journal of orthopaedic translation 2024 Jul;47:50-62
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.
Yang F, Wang P, Dong X, Dai W, Chen W, Yuan G, Bai D, Xu H
Oral diseases 2024 Jul;30(5):3308-3320
Oral diseases 2024 Jul;30(5):3308-3320
Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy.
Zhang D, Ma B, Liu D, Wu W, Zhou T, Gao Y, Yang C, Jian Y, Fan Y, Qian Y, Ma J, Gao Y, Chen Y, Xu S, Li L
EBioMedicine 2024 Jul;105:105212
EBioMedicine 2024 Jul;105:105212
Targeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid.
Wang L, Yao Q, Guo X, Wang B, Si J, Wang X, Jing S, Yan M, Shi Y, Song G, Shen X, Guan J, Zhao Y, Zhu C
Journal of nanobiotechnology 2024 Jul 4;22(1):392
Journal of nanobiotechnology 2024 Jul 4;22(1):392
Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy.
Shi P, Gao H, Cheng Z, Zhao K, Chen Y, Chen X, Gan W, Zhang A, Yang C, Zhang Y
Journal of nanobiotechnology 2024 Jul 31;22(1):457
Journal of nanobiotechnology 2024 Jul 31;22(1):457
Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1-STING axis.
Shi Y, Zhao L, Wang J, Liu X, Bai Y, Cong H, Li X
Cardiovascular diabetology 2024 Jul 23;23(1):269
Cardiovascular diabetology 2024 Jul 23;23(1):269
Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis.
Yao Y, Wang B, Yu K, Song J, Wang L, Zhang X, Li Y
Reproductive biology and endocrinology : RB&E 2024 Jul 23;22(1):86
Reproductive biology and endocrinology : RB&E 2024 Jul 23;22(1):86
Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues.
Wu J, Wang C, Sun S, Ren T, Pan L, Liu H, Hou S, Wu S, Yan X, Zhang J, Zhao X, Liu W, Zhu S, Wei S, Zhang C, Jia X, Zhang Q, Yu Z, Zhuo Y, Zhao Q, Yang C, Wang N
Protein & cell 2024 Jul 20;15(8):594-611
Protein & cell 2024 Jul 20;15(8):594-611
METTL1-modulated LSM14A facilitates proliferation and migration in glioblastoma via the stabilization of DDX5.
Wang C, He Y, Fang X, Zhang D, Huang J, Zhao S, Li L, Li G
iScience 2024 Jul 19;27(7):110225
iScience 2024 Jul 19;27(7):110225
MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.
Lu J, Zhao Q, Wang L, Li J, Wang H, Lv L, Yuan M, Chen Q, Zhang Z, Luo D, Sheng S, Yuan K, Liu G, Liu M, Shi Y, Guo Y, Dong Z
iScience 2024 Jul 19;27(7):110163
iScience 2024 Jul 19;27(7):110163
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution.
Ma L, He X, Fu Y, Ge S, Yang Z
Journal of translational medicine 2024 Jul 1;22(1):605
Journal of translational medicine 2024 Jul 1;22(1):605
Bavachinin protects the liver in NAFLD by promoting regeneration via targeting PCNA.
Dong X, Lu S, Tian Y, Ma H, Wang Y, Zhang X, Sun G, Luo Y, Sun X
Journal of advanced research 2024 Jan;55:131-144
Journal of advanced research 2024 Jan;55:131-144
Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.
Li F, Liu J, Miao J, Hong F, Liu R, Lv Y, Yang Y, He A, Wang J
DNA and cell biology 2024 Jan;43(1):39-55
DNA and cell biology 2024 Jan;43(1):39-55
High glucose levels delay the senescence of stem cells from human exfoliated deciduous teeth by suppressing autophagy.
Lu J, Zhang L, Zhu N, Wang D, Xie F, Qin M, Wang Y
Archives of oral biology 2024 Jan;157:105851
Archives of oral biology 2024 Jan;157:105851
Epiberberine induced p53/p21-dependent G2/M cell cycle arrest and cell apoptosis in gastric cancer cells by activating γ-aminobutyric acid receptor- β3.
Li M, Yang J, Li J, Zhou Y, Li X, Ma Z, Li X, Ma H, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155198
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155198
Cellular and molecular mechanisms of highly active mesenchymal stem cells in the treatment of senescence of rhesus monkey ovary.
Wang K, Yao X, Lin SQ, Zhu XQ, Pan XH, Ruan GP
Stem cell research & therapy 2024 Jan 8;15(1):14
Stem cell research & therapy 2024 Jan 8;15(1):14
CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.
Shuai Y, Zhang H, Liu C, Wang J, Jiang Y, Sun J, Gao X, Bo X, Xiao X, Liao X, Huang C, Chen H, Jiang G
Cell death & disease 2024 Jan 5;15(1):9
Cell death & disease 2024 Jan 5;15(1):9
Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL.
Liang Y, Zhang X, Peng J, Liu J, Chen H, Guo S
Journal of cancer research and clinical oncology 2024 Jan 30;150(2):51
Journal of cancer research and clinical oncology 2024 Jan 30;150(2):51
Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.
Ding JH, Xiao Y, Yang F, Song XQ, Xu Y, Ding XH, Ding R, Shao ZM, Di GH, Jiang YZ
Science translational medicine 2024 Jan 3;16(728):eadg7740
Science translational medicine 2024 Jan 3;16(728):eadg7740
Mitophagy-Mediated Tumor Dormancy Protects Cancer Cells from Chemotherapy.
Sun Y, Chen Y, Liu Z, Wang J, Bai J, Du R, Long M, Shang Z
Biomedicines 2024 Jan 28;12(2)
Biomedicines 2024 Jan 28;12(2)
Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality.
Karnewar S, Karnewar V, Shankman LS, Owens GK
JCI insight 2024 Jan 23;9(2)
JCI insight 2024 Jan 23;9(2)
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z
Scientific reports 2024 Jan 16;14(1):1447
Scientific reports 2024 Jan 16;14(1):1447
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.
Min W, Wang Y, Shen H, Zheng M, Tong C, Shen H, Wang D, Zhu Y, Wang X, Xiao Y, Zhang XY, Yang P
European journal of medicinal chemistry 2024 Jan 15;264:116025
European journal of medicinal chemistry 2024 Jan 15;264:116025
Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G(2)/M phase arrest via PI3K/AKT signaling pathway.
Li K, You G, Jiang K, Wang R, Li W, Meng Y, Fang Y, Chen W, Zhu G, Song J, Wang W, Su H, Hu B, Sun F, Jia Z, Li C, Zhu J
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117014
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117014
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway.
Zhang B, Huang C, Xu D, Huang K, Li Y, Jiao L, Fu B, Li S, Li Y
Ecotoxicology and environmental safety 2024 Jan 1;269:115784
Ecotoxicology and environmental safety 2024 Jan 1;269:115784
Silencing geranylgeranyltransferase I inhibits the migration and invasion of salivary adenoid cystic carcinoma through RhoA/ROCK1/MLC signaling and suppresses proliferation through cell cycle regulation.
Chi Z, Wang Q, Tong L, Qiu J, Yang F, Guo Q, Li W, Zheng J, Chen Z
Cell biology international 2024 Feb;48(2):174-189
Cell biology international 2024 Feb;48(2):174-189
Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
Zhu W, Gui X, Zhou Y, Gao X, Zhang R, Li Q, Zhang H, Zhao J, Cui X, Gao G, Tang H, Huan C, Pan D, Song H, Zhou Z, Shen W
Experimental eye research 2024 Feb;239:109753
Experimental eye research 2024 Feb;239:109753
Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence.
Fan Z, Tong Y, Yang Z, Wang S, Huang T, Yang D, Ni Q, Zhang M, Li D, Yang M, Fan X
Experimental gerontology 2024 Feb;186:112359
Experimental gerontology 2024 Feb;186:112359
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Xing D, Jin Y, Sun D, Liu Y, Cai B, Gao C, Cui Y, Jin B
Archives of gerontology and geriatrics 2024 Feb;117:105274
Archives of gerontology and geriatrics 2024 Feb;117:105274
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells.
Choudhury D, Rong N, Senthil Kumar HV, Swedick S, Samuel RZ, Mehrotra P, Toftegaard J, Rajabian N, Thiyagarajan R, Podder AK, Wu Y, Shahini S, Seldeen KL, Troen B, Lei P, Andreadis ST
Cell reports 2024 Feb 27;43(2):113738
Cell reports 2024 Feb 27;43(2):113738
Prognosis and biological function of SGOL1 in clear cell renal cell carcinoma: a multiomics analysis.
Yang Z, Jiang Y, Wang L, Yu B, Cai H, Fan J, Zhang M
BMC medical genomics 2024 Feb 21;17(1):60
BMC medical genomics 2024 Feb 21;17(1):60
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress.
Deng X, Zhang Y, He X, Li L, Yue Z, Liang Y, Huang Y
Journal of bioenergetics and biomembranes 2024 Dec;56(6):619-630
Journal of bioenergetics and biomembranes 2024 Dec;56(6):619-630
ROS-Induced Gingival Fibroblast Senescence: Implications in Exacerbating Inflammatory Responses in Periodontal Disease.
Guo S, Fu L, Yin C, Shao W, Sun Q, Chen L, Xia T, Wang M, Xia H
Inflammation 2024 Dec;47(6):1918-1935
Inflammation 2024 Dec;47(6):1918-1935
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
H(2)Se-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence.
Yang F, Shu R, Dai W, Li B, Liu C, Yang H, Johnson HM, Yu S, Bai D, Yang W, Deng Y
Biomaterials 2024 Dec;311:122659
Biomaterials 2024 Dec;311:122659
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
Cai S, Ding R, Zhang H, Chen Q, Yu F, Xia Y, Chen Q, Miao X, Zhou B, Chen J, Liao L, Cheng X, Fu X
Materials today. Bio 2024 Dec;29:101323
Materials today. Bio 2024 Dec;29:101323
Single-cell transcriptomic atlas of taste papilla aging.
Ren W, Li W, Cha X, Wang S, Cai B, Wang T, Li F, Li T, Xie Y, Xu Z, Wang Z, Liu H, Yu Y
Aging cell 2024 Dec;23(12):e14308
Aging cell 2024 Dec;23(12):e14308
PiRNA CFAPIR inhibits cardiac fibrosis by regulating the muscleblind-like protein MBNL2.
Lv L, Yuan K, Li J, Lu J, Zhao Q, Wang H, Chen Q, Dong X, Sheng S, Liu M, Shi Y, Jiang H, Dong Z
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167456
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167456
Rosmarinic acid attenuates glioblastoma cells and spheroids' growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis.
Şengelen A, Önay-Uçar E
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156060
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156060
Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.
Yang Y, Shen J, Deng P, Chen P
Cancer biology & therapy 2024 Dec 31;25(1):2380023
Cancer biology & therapy 2024 Dec 31;25(1):2380023
Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients.
Yang K, Lu Y, Gu J, Nie Y, Zhang T
Scientific reports 2024 Dec 28;14(1):31445
Scientific reports 2024 Dec 28;14(1):31445
RBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma.
Pan H, Liao L, Xu S, Xu Y, Chai W, Liu X, Li J, Cao Y, Sun L, Liu Q, Yan M
Journal of translational medicine 2024 Dec 25;22(1):1147
Journal of translational medicine 2024 Dec 25;22(1):1147
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Sun J, Li Y, Meng M, Zeng X, Wang Q, Li W, Luo Y, Chen H, Dong Q
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Lin S, Li T, Zhang B, Wang P
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Biochemical and biophysical research communications 2024 Dec 20;739:150587
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
Jiang D, Qi Z, Xu ZY, Li YR
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?
Yang J, Yang X, Guo T, Wang L, Zhao Z, Hu Z, Li Y
Translational oncology 2024 Aug;46:102026
Translational oncology 2024 Aug;46:102026
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
Gu T, Wen Y, Zhou Q, Yuan W, Guo H, Chang WL, Yang Q
Mycotoxin research 2024 Aug;40(3):419-432
Mycotoxin research 2024 Aug;40(3):419-432
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway.
Xia Y, Zhang H, Wu X, Xu Y, Tan Q
Biogerontology 2024 Aug;25(4):649-664
Biogerontology 2024 Aug;25(4):649-664
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
Li H, Wan L, Liu M, Ma E, Huang L, Yang Y, Li Q, Fang Y, Li J, Han B, Zhang C, Sun L, Hou X, Li H, Sun M, Qian S, Duan X, Zhao R, Yang X, Chen Y, Wu S, Zhang X, Zhang Y, Cheng G, Chen G, Gao Q, Xu J, Hou L, Wei C, Zhong H
PLoS pathogens 2024 Aug;20(8):e1012291
PLoS pathogens 2024 Aug;20(8):e1012291
A Lipid-Sensitive Spider Peptide Toxin Exhibits Selective Anti-Leukemia Efficacy through Multimodal Mechanisms.
Zhang P, Luo W, Zhang Z, Lv M, Sang L, Wen Y, Wang L, Ding C, Wu K, Li F, Nie Y, Zhu J, Liu X, Yi Y, Ding X, Zeng Y, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2404937
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2404937
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Hou J, Lin Y, Zhu C, Chen Y, Lin R, Lin H, Liu D, Guan D, Yu B, Wang J, Wu H, Cui Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Nie P, Zhang C, Wu F, Chen S, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Mitochondrial copper overload promotes renal fibrosis via inhibiting pyruvate dehydrogenase activity.
Zhu S, Niu Y, Zhou W, Liu Y, Liu J, Liu X, Lu L, Yu C
Cellular and molecular life sciences : CMLS 2024 Aug 9;81(1):340
Cellular and molecular life sciences : CMLS 2024 Aug 9;81(1):340
Design and Discovery of New Collagen V-Derived FGF2-Blocking Natural Peptides Inhibiting Lung Squamous Cell Carcinoma In Vitro and In Vivo.
Kuang K, Chen X, Wang M, Han W, Qiu X, Jin T, Xu R, Yuan B, Qian M, Li C, Xiang R, Li F, Zhang S, Yang Z, Du J, Li D, Zhang C, Wang Q, Jia T
Journal of medicinal chemistry 2024 Aug 8;67(15):12660-12675
Journal of medicinal chemistry 2024 Aug 8;67(15):12660-12675
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Chen W, Yang KB, Zhang YZ, Lin ZS, Chen JW, Qi SF, Wu CF, Feng GK, Yang DJ, Chen M, Zhu XF, Li X
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells.
Turkoglu B, Mansuroglu B
Life (Basel, Switzerland) 2024 Aug 27;14(9)
Life (Basel, Switzerland) 2024 Aug 27;14(9)
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
The role of BUD31 in clear cell renal cell carcinoma: prognostic significance, alternative splicing, and tumor immune environment.
Wu X, Fan R, Zhang Y, Duan C, Yao X, Liu K, Lin D, Chen Z
Clinical and experimental medicine 2024 Aug 13;24(1):191
Clinical and experimental medicine 2024 Aug 13;24(1):191
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms.
Wang Y, Wen J, Sun X, Sun Y, Liu Y, Cheng X, Wu W, Liu Q, Ren F
Cancer chemotherapy and pharmacology 2024 Apr;93(4):295-306
Cancer chemotherapy and pharmacology 2024 Apr;93(4):295-306
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y
Redox biology 2024 Apr;70:103067
Redox biology 2024 Apr;70:103067
Sciellin promotes the development and progression of thyroid cancer through the JAK2/STAT3 signaling pathway.
Guo H, Wang Z, Yin K, Ma R, Zhang Y, Yin F, Li H, Yin D
Molecular carcinogenesis 2024 Apr;63(4):701-713
Molecular carcinogenesis 2024 Apr;63(4):701-713
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging.
Jia H, Chang Y, Chen Y, Chen X, Zhang H, Hua X, Xu M, Sheng Y, Zhang N, Cui H, Han L, Zhang J, Fu X, Song J
Communications biology 2024 Apr 8;7(1):427
Communications biology 2024 Apr 8;7(1):427
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome.
Tanaka T, Urata Y, Harada M, Kunitomi C, Kusamoto A, Koike H, Xu Z, Sakaguchi N, Tsuchida C, Komura A, Teshima A, Takahashi N, Wada-Hiraike O, Hirota Y, Osuga Y
Molecular human reproduction 2024 Apr 30;30(5)
Molecular human reproduction 2024 Apr 30;30(5)
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
Xiang Q, Qu L, Lei H, Duan Z, Zhu C, Yuwen W, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Chen SJ, Yu F, Feng X, Li Q, Jiang YH, Zhao LQ, Cheng PP, Wang M, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Shi Y, Huang D, Song C, Cao R, Wang Z, Wang D, Zhao L, Xu X, Lu C, Xiong F, Zhao H, Li S, Zhou Q, Luo S, Hu D, Zhang Y, Wang C, Shen Y, Su W, Wu Y, Schmitz K, Wei S, Song W
Nature communications 2024 Apr 26;15(1):3301
Nature communications 2024 Apr 26;15(1):3301
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H
Cell reports 2024 Apr 23;43(4):114111
Cell reports 2024 Apr 23;43(4):114111
Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells.
Wang S, Lei K, Lai HT, Liu T, Du L, Wu SY, Ye X, Chiang CM, Li M
ACS pharmacology & translational science 2024 Apr 12;7(4):1178-1190
ACS pharmacology & translational science 2024 Apr 12;7(4):1178-1190
The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component.
Ma Y, Li S, Ye S, Luo S, Wei L, Su Y, Zeng Y, Shi Y, Bian H, Xiao F
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123535
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123535
Chronic low-dose deltamethrin exposure induces colon injury and aggravates DSS-induced colitis via promoting cellular senescence.
Ma R, Wang X, Ren K, Ma Y, Min T, Yang Y, Xie X, Li K, Zhu K, Yuan D, Mo C, Deng X, Zhang Y, Dang C, Zhang H, Sun T
Ecotoxicology and environmental safety 2024 Apr 1;274:116214
Ecotoxicology and environmental safety 2024 Apr 1;274:116214
Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.
Chi B, Zou A, Mao L, Cai D, Xiao T, Wang Y, Wang Q, Ji Y, Sun L
Oxidative medicine and cellular longevity 2023;2023:7747727
Oxidative medicine and cellular longevity 2023;2023:7747727
Effects of Ginsenoside Rg1 on the Biological Behavior of Human Amnion-Derived Mesenchymal Stem/Stromal Cells (hAD-MSCs).
Ling L, Shu H, Huang Y, Hou J, Hua Y
Stem cells international 2023;2023:7074703
Stem cells international 2023;2023:7074703
IFN-α-2b Reduces Postoperative Arthrofibrosis in Rats by Inhibiting Fibroblast Proliferation and Migration through STAT1/p21 Signaling Pathway.
Liu Z, Fan Z, Wang R, Li X, Chen H, Wang J
Mediators of inflammation 2023;2023:1699946
Mediators of inflammation 2023;2023:1699946
SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation.
Han M, Guo Y, Li Y, Zeng Q, Zhu W, Jiang J
International journal of biological sciences 2023;19(11):3324-3340
International journal of biological sciences 2023;19(11):3324-3340
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Zhu Y, Sun W, Jiang X, Bai R, Luo Y, Gao Y, Li S, Huang Z, Gong Y, Xie C
PloS one 2023;18(1):e0281132
PloS one 2023;18(1):e0281132
The cancer/testis antigen HORMAD1 promotes gastric cancer progression by activating the NF-κB signaling pathway and inducing epithelial-mesenchymal transition.
Bian G, Li W, Huang D, Zhang Q, Ding X, Zang X, Ye Y, Cao J, Li P
American journal of translational research 2023;15(9):5808-5825
American journal of translational research 2023;15(9):5808-5825
SHCBP1 Promotes the Proliferation of Breast Cancer Cells by Inhibiting CXCL2.
Yu X, Feng G, Nian R, Han S, Ke M, Wang L, Li W, Tian S, Lu H
Journal of Cancer 2023;14(18):3444-3456
Journal of Cancer 2023;14(18):3444-3456
Immunological characterization of stroke-heart syndrome and identification of inflammatory therapeutic targets.
Zheng J, Ma Y, Guo X, Wu J
Frontiers in immunology 2023;14:1227104
Frontiers in immunology 2023;14:1227104
Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.
Wang K, Lu H, Wang X, Liu Q, Hu J, Liu Y, Jin M, Kong D
Frontiers in pharmacology 2023;14:1200538
Frontiers in pharmacology 2023;14:1200538
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway.
Xiong D, Gao F, Shao J, Pan Y, Wang S, Wei D, Ye S, Chen Y, Chen R, Yue B, Li J, Chen J
Frontiers in pharmacology 2023;14:1141800
Frontiers in pharmacology 2023;14:1141800
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Jia M, Zhou KY, Deng LJ, Fang S
American journal of cancer research 2023;13(7):3013-3026
American journal of cancer research 2023;13(7):3013-3026
Fanconi anemia pathway regulation by FANCI in prostate cancer.
Kaljunen H, Taavitsainen S, Kaarijärvi R, Takala E, Paakinaho V, Nykter M, Bova GS, Ketola K
Frontiers in oncology 2023;13:1260826
Frontiers in oncology 2023;13:1260826
PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer.
He Q, Ding Z, Chen T, Wu H, Song J, Xiang Z, Yang C, Wang S, Xiong B
Frontiers in oncology 2023;13:1164070
Frontiers in oncology 2023;13:1164070
Triptolide inhibits the progression of Glioblastoma U251 cells via targeting PROX1.
Yuan C, Liao Y, Liao S, Huang M, Li D, Wu W, Quan Y, Li L, Yu X, Si W
Frontiers in oncology 2023;13:1077640
Frontiers in oncology 2023;13:1077640
Bazi Bushen alleviates skin senescence by orchestrating skin homeostasis in SAMP6 mice.
Xu Z, Gong B, Li Z, Wang Y, Zhao Z, Xie L, Peng Y, Zhao S, Zhou H, Bian Y
Journal of cellular and molecular medicine 2023 Sep;27(18):2651-2660
Journal of cellular and molecular medicine 2023 Sep;27(18):2651-2660
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Hu S, Yang M, Xiao K, Yang Z, Cai L, Xie Y, Wang L, Wei R
Experimental and therapeutic medicine 2023 Sep;26(3):457
Experimental and therapeutic medicine 2023 Sep;26(3):457
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2.
Sun J, Lui K, Pang Q, Xu M, Zhao H, Shao J, Yu Y, Chu X, Liang Y, Xu J, Shen Z
Journal of cancer research and clinical oncology 2023 Sep;149(12):10781-10796
Journal of cancer research and clinical oncology 2023 Sep;149(12):10781-10796
Fangchinoline derivatives inhibits PI3K signaling in vitro and in vivo in non-small cell lung cancer.
Chen JS, Guo X, Sun JY, Wang MX, Gao XZ, Wang Z, Han JL, Sun H, Zhang K, Liu C
Bioorganic chemistry 2023 Sep;138:106623
Bioorganic chemistry 2023 Sep;138:106623
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Guo Y, Shao J, Zhang R, Han M, Kong L, Liu Z, Li H, Wei D, Lu M, Zhang S, Zhang C, Wei H, Chen Z, Bian H
International journal of molecular sciences 2023 Sep 7;24(18)
International journal of molecular sciences 2023 Sep 7;24(18)
Silencing of LINC00467 inhibits cell proliferation in testicular germ cell tumors cells.
Zhu F, Liu Z, Zhou Q, Zhou D, Fan J, Bo H, Fan L
Biomolecules & biomedicine 2023 Sep 4;23(5):802-814
Biomolecules & biomedicine 2023 Sep 4;23(5):802-814
miR-491-5p regulates the susceptibility of glioblastoma to ferroptosis through TP53.
Jie XF, Li YP, Liu S, Fu Y, Xiong YY
Biochemical and biophysical research communications 2023 Sep 3;671:309-317
Biochemical and biophysical research communications 2023 Sep 3;671:309-317
Multi-omic analysis of mandibuloacral dysplasia type A patient iPSC-derived MSC senescence reveals miR-311 as a novel biomarker for MSC senescence.
He L, Liao J, Liu Z, Wang T, Zhou Y, Wang T, Lei B, Zhou G
Human molecular genetics 2023 Sep 16;32(19):2872-2886
Human molecular genetics 2023 Sep 16;32(19):2872-2886
Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.
Lan X, Lu M, Fang X, Cao Y, Sun M, Shan M, Gao W, Wang Y, Yu W, Luo H
Molecules (Basel, Switzerland) 2023 Sep 15;28(18)
Molecules (Basel, Switzerland) 2023 Sep 15;28(18)
Elabela inhibits TRAF1/NF-κB induced oxidative DNA damage to promote diabetic foot ulcer wound healing.
Hong Y, Li J, Zhong Y, Yang S, Pei L, Huang Z, Chen X, Wu H, Zheng G, Zeng C, Wu H, Wang T
iScience 2023 Sep 15;26(9):107601
iScience 2023 Sep 15;26(9):107601
Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE-Choroid.
Wang Y, Tseng Y, Chen K, Chen K, Chen K, Huang Z, Mao Z, Li X
Investigative ophthalmology & visual science 2023 Sep 1;64(12):39
Investigative ophthalmology & visual science 2023 Sep 1;64(12):39
RIG-I promotes cell proliferation in esophageal squamous cell carcinoma by facilitating p21 degradation.
Wang M, Zhang Y, Gao L, Zhang H, Yang Z, Liu J, Shan W, Zeng L, Zhang R, Li Y, Liu J
Medical oncology (Northwood, London, England) 2023 Sep 1;40(10):288
Medical oncology (Northwood, London, England) 2023 Sep 1;40(10):288
Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells.
Guo Y, Zhou A, Zhang Y, Chen Y, Chen Y, Gao Y, Miao X
Life sciences 2023 Sep 1;328:121824
Life sciences 2023 Sep 1;328:121824
PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
Wang L, Yue Y, Zhang L, Jing M, Ma M, Liu C, Li Y, Xu S, Wang K, Wang X, Fan J, Zhang M
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1317-1332
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1317-1332
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Zhang M, Zhu LZ, Yang CJ, Yan JX, Wang ZP, Bai YP, Peng LZ, Luo HB, Zhang ZJ, Li L, Xu CR, Liu YQ
Bioorganic chemistry 2023 Oct;139:106652
Bioorganic chemistry 2023 Oct;139:106652
Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts.
Li N, Yan X, Cui X, Zhao C, Lin Z, Miao J
Journal of cellular biochemistry 2023 Oct;124(10):1603-1614
Journal of cellular biochemistry 2023 Oct;124(10):1603-1614
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.
Ding Z, Pan Y, Shang T, Jiang T, Lin Y, Yang C, Pang S, Cui X, Wang Y, Feng XF, Xu M, Pei M, Chen Y, Li X, Ding J, Tan Y, Wang H, Dong L, Wang L
Nature communications 2023 Oct 7;14(1):6269
Nature communications 2023 Oct 7;14(1):6269
The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma.
Luo H, Huang K, Cheng M, Long X, Zhu X, Wu M
Aging 2023 Oct 17;15(20):11052-11066
Aging 2023 Oct 17;15(20):11052-11066
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.
Li W, Li D, Ma Q, Chen Y, Hu Z, Bai Y, Xie L
European journal of pharmacology 2023 Oct 15;957:176035
European journal of pharmacology 2023 Oct 15;957:176035
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer.
Zhao S, Li Y, Li G, Ye J, Wang R, Zhang X, Li F, Gao C, Li J, Jiang J, Mi Y
European journal of pharmacology 2023 Oct 15;957:176004
European journal of pharmacology 2023 Oct 15;957:176004
Umbilical Cord Mesenchymal-Stem-Cell-Derived Exosomes Exhibit Anti-Oxidant and Antiviral Effects as Cell-Free Therapies.
Meng Y, Li C, Liang Y, Jiang Y, Zhang H, Ouyang J, Zhang W, Deng R, Tan Q, Yu X, Luo Z
Viruses 2023 Oct 15;15(10)
Viruses 2023 Oct 15;15(10)
Inhibition of autophagy can promote the apoptosis of bladder cancer cells induced by SC66 through the endoplasmic reticulum stress pathway.
Wang L, Song R, Ma M, Chen Y, Jiang Y, Li J, Yang Z, Zhang L, Jing M, Wang X, Zhang M, Fan J
Chemico-biological interactions 2023 Oct 1;384:110725
Chemico-biological interactions 2023 Oct 1;384:110725
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Xie J, Tang Z, Chen Q, Jia X, Li C, Jin M, Wei G, Zheng H, Li X, Chen Y, Liao W, Liao Y, Bin J, Huang S
Aging and disease 2023 Oct 1;14(5):1778-1798
Aging and disease 2023 Oct 1;14(5):1778-1798
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer.
Yang K, Wang JQ, Li K, Chen SN, Yu F
Oncology reports 2023 Nov;50(5)
Oncology reports 2023 Nov;50(5)
Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway.
Huang ZN, Wang ZY, Cheng XF, Huang ZZ, Han YL, Cui YZ, Liu B, Tian W
Journal of orthopaedic translation 2023 Nov;43:66-84
Journal of orthopaedic translation 2023 Nov;43:66-84
TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.
Zhang F, Zhu T, Wu C, Shen D, Liu L, Chen X, Guan Y, Ding H, Tong X
Human cell 2023 Nov;36(6):2113-2128
Human cell 2023 Nov;36(6):2113-2128
Hydrogen sulfide inhibits the rupture of fetal membranes throngh anti-aging pathways.
Wang J, Xu J, Chao B, Liu H, Xie L, Qi H, Luo X
Placenta 2023 Nov;143:22-33
Placenta 2023 Nov;143:22-33
IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A.
Yang LR, Li L, Meng MY, Li TT, Zhao YY, Yang SL, Gao H, Tang WW, Yang Y, Yang LL, Wang WJ, Liao LW, Hou ZL
International immunopharmacology 2023 Nov;124(Pt B):110974
International immunopharmacology 2023 Nov;124(Pt B):110974
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Guo H, Chen J, Yu H, Dong L, Yu R, Li Q, Song J, Chen H, Zhang H, Pu J, Wang W
International immunopharmacology 2023 Nov;124(Pt A):110864
International immunopharmacology 2023 Nov;124(Pt A):110864
Combination of PARP inhibitor and CDK4/6 inhibitor modulates cGAS/STING-dependent therapy-induced senescence and provides "one-two punch" opportunity with anti-PD-L1 therapy in colorectal cancer.
Wang T, Liu W, Shen Q, Tao R, Li C, Shen Q, Lin Y, Huang Y, Yang L, Xie G, Bai J, Li R, Wang L, Tao K, Yin Y
Cancer science 2023 Nov;114(11):4184-4201
Cancer science 2023 Nov;114(11):4184-4201
Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.
Xu Z, Man SS, Gong BY, Li ZD, Zhou HF, Peng YF, Zhao SW, Hou YL, Wang L, Bian YH
Journal of the science of food and agriculture 2023 Nov;103(14):7273-7283
Journal of the science of food and agriculture 2023 Nov;103(14):7273-7283
Spontaneous p53 activation in middle-aged C57BL/6 mice mitigates the lifespan-extending adaptive response induced by low-dose ionizing radiation.
Kohzaki M, Suzuki K, Ootsuyama A, Okazaki R
npj aging 2023 Nov 7;9(1):26
npj aging 2023 Nov 7;9(1):26
Micronano Titanium Accelerates Mesenchymal Stem Cells Aging through the Activation of Senescence-Associated Secretory Phenotype.
Li X, Luo X, He Y, Xu K, Ding Y, Gao P, Tao B, Li M, Tan M, Liu S, Liu P, Cai K
ACS nano 2023 Nov 28;17(22):22885-22900
ACS nano 2023 Nov 28;17(22):22885-22900
Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.
Wang J, Mi Y, Sun X, Xue X, Zhao H, Zhang M, Hu B, Bukhari I, Zheng P
Aging 2023 Nov 27;15(22):13558-13578
Aging 2023 Nov 27;15(22):13558-13578
Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer.
Shi S, Guo D, Ye L, Li T, Fei Q, Lin M, Yu X, Jin K, Wu W
Cell death & disease 2023 Nov 27;14(11):778
Cell death & disease 2023 Nov 27;14(11):778
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability.
Kong K, Jin M, Zhao C, Qiao H, Chen X, Li B, Rong K, Zhang P, Shan Y, Xu Z, Chang Y, Li H, Zhai Z
iScience 2023 Nov 17;26(11):108119
iScience 2023 Nov 17;26(11):108119
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Duan J, Li Z, Liu E, Long H, Chen L, Yang S
Journal of ethnopharmacology 2023 Nov 15;316:116692
Journal of ethnopharmacology 2023 Nov 15;316:116692
Hydrogen sulfide ameliorates endothelial dysfunction in aging arteries by regulating ferroptosis.
Miao Y, Zhang S, Liang Z, Wang Y, Tian D, Jin S, Guo Q, Xue H, Teng X, Xiao L, Wu Y
Nitric oxide : biology and chemistry 2023 Nov 1;140-141:77-90
Nitric oxide : biology and chemistry 2023 Nov 1;140-141:77-90
N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1/p21(cip1/waf1)/CDK2-Cyclin E1 axis-mediated cell cycle transition.
Liu R, Miao J, Jia Y, Kong G, Hong F, Li F, Zhai M, Zhang R, Liu J, Xu X, Wang T, Liu H, Hu J, Yang Y, He A
Oncogene 2023 May;42(20):1607-1619
Oncogene 2023 May;42(20):1607-1619
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
Xia G, Wen Z, Zhang L, Huang J, Wang X, Liang C, Cui X, Cao X, Wu S
Experimental gerontology 2023 May;175:112140
Experimental gerontology 2023 May;175:112140
Angelicin impedes the progression of glioblastoma via inactivation of YAP signaling pathway.
Wang M, Xing S, Jia J, Zeng W, Lei J, Qian Y, Xiong Z, Wang X, Cao L, Wang Y, Wang Y, Jiang Y, Huang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114462
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114462
Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development.
Sun XL, Chen ZH, Guo X, Wang J, Ge M, Wong SZH, Wang T, Li S, Yao M, Johnston LA, Wu QF
Developmental cell 2023 May 8;58(9):744-759.e11
Developmental cell 2023 May 8;58(9):744-759.e11
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Shang Z, Fan M, Zhang J, Wang Z, Jiang S, Li W
International journal of molecular sciences 2023 May 4;24(9)
International journal of molecular sciences 2023 May 4;24(9)
Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53.
Zhang Y, Guo T, Li S, Ren Z, Gao S, Lu H, Ma X, Liu D, Liu Y, Kong D, Qiu Y
Discover oncology 2023 May 31;14(1):84
Discover oncology 2023 May 31;14(1):84
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Zhou Z, Zhang H, Tao Y, Jie H, Zhao J, Zang J, Li H, Wang Y, Wang T, Zhao H, Li Y, Guo C, Zhu F, Mao H, Zhang L, Liu F, Wang Q
Cell reports 2023 May 30;42(5):112424
Cell reports 2023 May 30;42(5):112424
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
Jin Y, Zhao L, Wang S, Zhang X, Quan J, Lin Z, Piao J
Carcinogenesis 2023 May 26;44(2):129-142
Carcinogenesis 2023 May 26;44(2):129-142
The Males Absent on the First (MOF) Mediated Acetylation Alters the Protein Stability and Transcriptional Activity of YY1 in HCT116 Cells.
Wu T, Zhao B, Cai C, Chen Y, Miao Y, Chu J, Sui Y, Li F, Chen W, Cai Y, Wang F, Jin J
International journal of molecular sciences 2023 May 13;24(10)
International journal of molecular sciences 2023 May 13;24(10)
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors.
Li WF, Alfason L, Huang C, Tang Y, Qiu L, Miyagishi M, Wu SR, Kasim V
Acta pharmacologica Sinica 2023 Mar;44(3):647-660
Acta pharmacologica Sinica 2023 Mar;44(3):647-660
A Comprehensive Analysis Revealing FBXW9 as a Potential Prognostic and Immunological Biomarker in Breast Cancer.
Yu S, Liang Z, Fan Z, Cao B, Wang N, Wu R, Sun H
International journal of molecular sciences 2023 Mar 9;24(6)
International journal of molecular sciences 2023 Mar 9;24(6)
A Novel Three-Dimensional Follicle Culture System Decreases Oxidative Stress and Promotes the Prolonged Culture of Human Granulosa Cells.
Zhao X, Zhang S, Gao S, Chang HM, Leung PCK, Tan J
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095
ACS applied materials & interfaces 2023 Mar 29;15(12):15084-15095
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Qiu Q, Guo G, Guo X, Hu X, Yu T, Liu G, Zhang H, Chen Y, She J
Biomedicines 2023 Mar 13;11(3)
Biomedicines 2023 Mar 13;11(3)
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Wu Y, Tang L, Huang H, Yu Q, Hu B, Wang G, Ge F, Yin T, Li S, Yu X
Nature communications 2023 Mar 10;14(1):1323
Nature communications 2023 Mar 10;14(1):1323
Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.
Wang Y, Xiong X, Wang K, Bao Y, Zhang T, Ainiwaer D, Wang G, Li H, Sun Z
Tissue & cell 2023 Jun;82:102049
Tissue & cell 2023 Jun;82:102049
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
Ma L, Li K, Wei W, Zhou J, Li Z, Zhang T, Wangsun Y, Tian F, Dong Q, Zhang H, Xing W
Redox biology 2023 Jun;62:102693
Redox biology 2023 Jun;62:102693
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM
Cell proliferation 2023 Jun;56(6):e13435
Cell proliferation 2023 Jun;56(6):e13435
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
Gong W, Guo Y, Yuan H, Chai R, Wan Z, Zheng B, Hu X, Chen B, Gao S, Dai Q, Yu P, Tu S
Cancer gene therapy 2023 Jun;30(6):905-916
Cancer gene therapy 2023 Jun;30(6):905-916
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Lycopene suppresses gastric cancer cell growth without affecting normal gastric epithelial cells.
Zhou Y, Fu R, Yang M, Liu W, Tong Z
The Journal of nutritional biochemistry 2023 Jun;116:109313
The Journal of nutritional biochemistry 2023 Jun;116:109313
EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.
Yang X, Han F, Hu X, Li G, Wu H, Can C, Wei Y, Liu J, Wang R, Jia W, Ji C, Ma D
Biomarker research 2023 Jun 6;11(1):59
Biomarker research 2023 Jun 6;11(1):59
Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition.
Liu W, Ji Y, Wang F, Li C, Shi S, Liu R, Li Q, Guo L, Liu Y, Cui H
BMC cancer 2023 Jun 29;23(1):602
BMC cancer 2023 Jun 29;23(1):602
SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.
Li Q, Xie B, Chen X, Lu B, Chen S, Sheng X, Zhao Y
Cell death discovery 2023 Jun 27;9(1):192
Cell death discovery 2023 Jun 27;9(1):192
TRIM29 hypermethylation drives esophageal cancer progression via suppression of ZNF750.
Yi Q, Zhao Y, Xia R, Wei Q, Chao F, Zhang R, Bian P, Lv L
Cell death discovery 2023 Jun 26;9(1):191
Cell death discovery 2023 Jun 26;9(1):191
Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells.
Shah JA, Miao Y, Chu J, Chen W, Zhao Q, Cai C, Khattak S, Wang F, Jin J
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex.
Feng L, Shang RR, Wang XJ, Li L, Li X, Gong YX, Shi LY, Wang JW, Qian ZY, Tan NH, Wang Z
Journal of natural products 2023 Jun 23;86(6):1449-1462
Journal of natural products 2023 Jun 23;86(6):1449-1462
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Wang X, Wang J, Zhao X, Wu H, Li J, Cheng Y, Guo Q, Cao X, Liang T, Sun L, Zhang G
Journal of translational medicine 2023 Jun 23;21(1):407
Journal of translational medicine 2023 Jun 23;21(1):407
Oridonin impedes breast cancer growth by blocking cells in S phase and inhibiting the PI3K/AKT/mTOR signaling pathway.
Zhang W, Shi L, Zhou W, Liu X, Xi Y, Wang X, Li Y, Xu X, Tang Y
Heliyon 2023 Jul;9(7):e18046
Heliyon 2023 Jul;9(7):e18046
USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation.
Ma C, Wang D, Tian Z, Gao W, Zang Y, Qian L, Xu X, Jia J, Liu Z
Oncogene 2023 Jul;42(29):2249-2262
Oncogene 2023 Jul;42(29):2249-2262
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Liang C, Yi K, Zhou X, Li X, Zhong C, Cao H, Xie C, Zhu J
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Deng X, Zeng Y, Qiu X, Zhong M, Xiong X, Luo M, Zhang J, Chen X
Leukemia research 2023 Jul;130:107312
Leukemia research 2023 Jul;130:107312
SELENOF Controls Proliferation and Cell Death in Breast-Derived Immortalized and Cancer Cells.
Ekyalongo RC, Flowers B, Sharma T, Zigrossi A, Zhang A, Quintanilla-Arteaga A, Singh K, Kastrati I
Cancers 2023 Jul 19;15(14)
Cancers 2023 Jul 19;15(14)
Cold exposure protects against medial arterial calcification development via autophagy.
Li FX, Liu JJ, Xu F, Shan SK, Zheng MH, Lei LM, Lin X, Guo B, Li CC, Wu F, Tang KX, Cao YC, Wu YY, Duan JY, Wu YL, He SY, Chen X, Yuan LQ
Journal of nanobiotechnology 2023 Jul 17;21(1):226
Journal of nanobiotechnology 2023 Jul 17;21(1):226
Treatment of advanced atherosclerotic mice with the senolytic agent ABT-263 is associated with reduced indices of plaque stability and increased mortality.
Karnewar S, Karnewar V, Shankman LS, Owens GK
bioRxiv : the preprint server for biology 2023 Jul 13;
bioRxiv : the preprint server for biology 2023 Jul 13;
RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.
Huang P, Wang F, Wang X, Meng X, Qiao W, Meng L
International endodontic journal 2023 Jan;56(1):39-52
International endodontic journal 2023 Jan;56(1):39-52
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Li H, Ren J, Cui H, Wang D, Zhao R, Liu X, Tian S, Wang J, Zhang J, Li P, Thorne RF, Duan S
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Cell transplantation 2023 Jan-Dec;32:9636897231177356
NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.
Wu G, Su Q, Li J, Xue C, Zhu J, Cai Q, Huang J, Ji S, Cheng B, Ge H
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Journal of nanobiotechnology 2023 Jan 5;21(1):7
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Li M, Li T, Yin J, Xie C, Zhu J
Toxicology 2023 Jan 15;484:153408
Toxicology 2023 Jan 15;484:153408
Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2).
Chan CY, Hong SC, Chang CM, Chen YH, Liao PC, Huang CY
Cells 2023 Jan 1;12(1)
Cells 2023 Jan 1;12(1)
Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1.
Zhang N, Hu Q, Sui T, Fu L, Zhang X, Wang Y, Zhu X, Huang B, Lu J, Li Z, Zhang Y
Nature aging 2023 Feb;3(2):185-201
Nature aging 2023 Feb;3(2):185-201
Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis.
Sun J, Belke D, Gui Y, Chen YX, Zhou S, Zheng XL
Cell death discovery 2023 Feb 7;9(1):49
Cell death discovery 2023 Feb 7;9(1):49
saKLK1-374 is more difficult to induce KLK1 expression in normal prostate cell lines than that in prostate cancer cell lines: Rethinking the universality of RNA activation.
Zhang M, Lin D, Luo C, Wei P, Cui K, Chen K, Chen Z
Biochemical and biophysical research communications 2023 Feb 5;643:157-168
Biochemical and biophysical research communications 2023 Feb 5;643:157-168
Particle Debris Generated from Passenger Tires Induces Morphological and Gene Expression Alterations in the Macrophages Cell Line RAW 264.7.
Poma A, Aloisi M, Bonfigli A, Colafarina S, Zarivi O, Aimola P, Vecchiotti G, Arrizza L, Di Cola A, Cesare P
Nanomaterials (Basel, Switzerland) 2023 Feb 17;13(4)
Nanomaterials (Basel, Switzerland) 2023 Feb 17;13(4)
Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.
Gao X, Jiang P, Wei X, Zhang W, Zheng J, Sun S, Yao H, Liu X, Zhang Q
BMC cancer 2023 Feb 15;23(1):154
BMC cancer 2023 Feb 15;23(1):154
MicroRNA-499-5p promotes vascular smooth muscle cell proliferation and migration via inhibiting SOX6.
Sheng Y, Yang Z, Feng Z, Wang Y, Ji N
Physiological genomics 2023 Feb 1;55(2):67-74
Physiological genomics 2023 Feb 1;55(2):67-74
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Bai Y, Zhou L, Zhang C, Guo M, Xia L, Tang Z, Liu Y, Deng S
Oncogene 2023 Dec;42(49):3605-3618
Oncogene 2023 Dec;42(49):3605-3618
Chidamide Induces Epstein-Barr Virus (EBV) Lytic Infection and Acts Synergistically with Tenofovir to Eliminate EBV-Positive Burkitt Lymphoma.
Xu L, Zhang M, Tu D, Lu Z, Lu T, Ma D, Zhou Y, Zhang S, Ma Y, Yan D, Wang X, Sang W
The Journal of pharmacology and experimental therapeutics 2023 Dec;387(3):288-298
The Journal of pharmacology and experimental therapeutics 2023 Dec;387(3):288-298
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Wang R, Li J, Fu Y, Li Y, Qi Y, Li C, Gao F, Li C
Biochemical pharmacology 2023 Dec;218:115874
Biochemical pharmacology 2023 Dec;218:115874
Exogenous H(2)S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice.
E Y, Lin Y, Yan G, Yang J, Jiao L, Wu R, Yan Q, Chen Y, Chen Y, Yan X, Li H
Biochimica et biophysica acta. Molecular cell research 2023 Dec;1870(8):119568
Biochimica et biophysica acta. Molecular cell research 2023 Dec;1870(8):119568
HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1 expression.
Yang Y, Zhang M, Zhao Y, Deng T, Zhou X, Qian H, Wang M, Zhang C, Huo Z, Mao Z, Shao Z, Liu M, Yang C, Lin C, Xu F, Tian G, Zhang Y
Cancer science 2023 Dec;114(12):4583-4595
Cancer science 2023 Dec;114(12):4583-4595
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X, Zhu Y, Wang C
Nature communications 2023 Dec 9;14(1):8151
Nature communications 2023 Dec 9;14(1):8151
The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency.
Xu Z, Takahashi N, Harada M, Kunitomi C, Kusamoto A, Koike H, Tanaka T, Sakaguchi N, Urata Y, Wada-Hiraike O, Hirota Y, Osuga Y
International journal of molecular sciences 2023 Dec 6;24(24)
International journal of molecular sciences 2023 Dec 6;24(24)
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis.
Yang Y, Zeng Z, Li L, Lei S, Wu Y, Chen T, Zhang J
Cancer biology & therapy 2023 Dec 31;24(1):2249170
Cancer biology & therapy 2023 Dec 31;24(1):2249170
Lnc-PKNOX1-1 inhibits tumor progression in cutaneous malignant melanoma by regulating NF-κB/IL-8 axis.
Hong A, Cao M, Li D, Wang Y, Zhang G, Fang F, Zhao L, Wang Q, Lin T, Wang Y
Carcinogenesis 2023 Dec 30;44(12):871-883
Carcinogenesis 2023 Dec 30;44(12):871-883
Cellular senescence contributes to mechanical ventilation-induced diaphragm dysfunction by upregulating p53 signalling pathways.
Shen W, Jiang Y, Xu Y, Qian X, Jia J, Ding Y, He Y, Pan Q, Zhuang J, Ge H, Xu P
BMC pulmonary medicine 2023 Dec 14;23(1):509
BMC pulmonary medicine 2023 Dec 14;23(1):509
Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration.
Lei M, Lin H, Shi D, Hong P, Song H, Herman B, Liao Z, Yang C
Cellular & molecular biology letters 2023 Dec 13;28(1):104
Cellular & molecular biology letters 2023 Dec 13;28(1):104
Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes.
Tai S, Zhou Y, Fu L, Ding H, Zhou Y, Yin Z, Yang R, Liu Z, Zhou S
Heliyon 2023 Aug;9(8):e19152
Heliyon 2023 Aug;9(8):e19152
The MAD2B-APC/C-MDM2 axis mediates acute kidney injury by modulating p53.
Hao Z, Yuan Q, Tang H, Lei C, Chen Y, Su H, Zhang C
The FEBS journal 2023 Aug;290(15):3858-3876
The FEBS journal 2023 Aug;290(15):3858-3876
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Yidian W, Jihe K, Xudong G, Daxue Z, Mingqiang L, Xuewen K
World neurosurgery 2023 Aug;176:e109-e124
World neurosurgery 2023 Aug;176:e109-e124
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Wang H, Qiu Y, Zhang H, Chang N, Hu Y, Chen J, Hu R, Liao P, Li Z, Yang Y, Cen Q, Ding X, Li M, Xie X, Li Y
Cell death & disease 2023 Aug 4;14(8):498
Cell death & disease 2023 Aug 4;14(8):498
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
Uemura T, Matsunaga M, Yokota Y, Takao K, Furuchi T
International journal of molecular sciences 2023 Aug 29;24(17)
International journal of molecular sciences 2023 Aug 29;24(17)
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.
Zhao WJ, Liu X, Hu M, Zhang Y, Shi PZ, Wang JW, Lu XH, Cheng XF, Tao YP, Feng XM, Wang YX, Zhang L
World journal of stem cells 2023 Aug 26;15(8):842-865
World journal of stem cells 2023 Aug 26;15(8):842-865
PNU-74654 Induces Cell Cycle Arrest and Inhibits EMT Progression in Pancreatic Cancer.
Chien TL, Wu YC, Lee HL, Sung WW, Yu CY, Chang YC, Lin CC, Wang CC, Tsai MC
Medicina (Kaunas, Lithuania) 2023 Aug 24;59(9)
Medicina (Kaunas, Lithuania) 2023 Aug 24;59(9)
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
Xiong H, Ren S, Chen J, Yang X, Liu Y, Xu Z, Guo J, Jiang T, Yuan M, Liu Y, Zhang G, Li W, Machens HG, Chen Z
Stem cell research & therapy 2023 Aug 21;14(1):213
Stem cell research & therapy 2023 Aug 21;14(1):213
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Zhang X, Liu T, Hou X, Zhou Z, Zhang F, Ma H, Wu X, Jiang J
Scientific reports 2023 Aug 14;13(1):13213
Scientific reports 2023 Aug 14;13(1):13213
Low-dose graphene oxide promotes tumor cells proliferation by activating PI3K-AKT-mTOR signaling via cellular membrane protein integrin αV.
Zheng Z, Halifu A, Ma J, Liu L, Fu Q, Yi B, Du E, Tian D, Xu Y, Zhang Z, Zhu J
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121817
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121817
TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle.
Jiang Y, Zhu C, Huang H, Huang G, Fu B, Xi X
BMC cancer 2023 Aug 1;23(1):716
BMC cancer 2023 Aug 1;23(1):716
Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.
Wang ZH, Ye LL, Xiang X, Wei XS, Niu YR, Peng WB, Zhang SY, Zhang P, Xue QQ, Wang HL, Du YH, Liu Y, Ai JQ, Zhou Q
Translational oncology 2023 Apr;30:101635
Translational oncology 2023 Apr;30:101635
The flavonoid GL-V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells.
Zhao J, Bai D, Qi L, Cao W, Du J, Gu C, Zhou C, Gao Y, Zhang L, Zhao Y, Lu N
British journal of pharmacology 2023 Apr;180(8):1072-1089
British journal of pharmacology 2023 Apr;180(8):1072-1089
Delivery of miR-3529-3p using MnO(2) -SiO(2) -APTES nanoparticles combined with phototherapy suppresses lung adenocarcinoma progression by targeting HIGD1A.
Zhang Y, Wang RR, Liu R, Xie SY, Jiao F, Li YJ, Xin J, Zhang H, Wang Z, Yan YF
Thoracic cancer 2023 Apr;14(10):913-928
Thoracic cancer 2023 Apr;14(10):913-928
Long non-coding RNA DINO promotes cisplatin sensitivity in lung adenocarcinoma via the p53-Bax axis.
Liu Z, Wang Q, Bi Y, Chubarov AS, Li Y, Liu L, Yang X, Dmitrienko EV, Zheng Y
Journal of thoracic disease 2023 Apr 28;15(4):2198-2212
Journal of thoracic disease 2023 Apr 28;15(4):2198-2212
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma.
Hsieh TY, Sung WW, Chang YC, Yu CY, Lu LY, Dong C, Lee TH, Chen SL
Aging 2023 Apr 21;15(8):3107-3119
Aging 2023 Apr 21;15(8):3107-3119
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.
Hou Z, Yan M, Li H, Wang W, You S, Wang M, Du T, Gong H, Li W, Guo L, Wei S, Zhang B, Ji M, Chen X
Toxicology letters 2023 Apr 15;379:67-75
Toxicology letters 2023 Apr 15;379:67-75
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Liang Z, Miao Y, Teng X, Xiao L, Guo Q, Xue H, Tian D, Jin S, Wu Y
Frontiers in molecular biosciences 2022;9:947778
Frontiers in molecular biosciences 2022;9:947778
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Zou P, Zhang X, Zhang R, Chai X, Zhao Y, Li E, Zhang Q, Yan R, Yang J, Liao B
Frontiers in molecular biosciences 2022;9:853654
Frontiers in molecular biosciences 2022;9:853654
Promotion of Cervical Cancer Cell Proliferation by miR-130b Expression Level Changes and Inhibition of its Apoptosis by Targeting CDKN1A Gene.
Wang Y, Yang L, Fan C, Mu H, Han M, Liu T, Xie L, Gao Q
Current cancer drug targets 2022;22(2):153-168
Current cancer drug targets 2022;22(2):153-168
MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B.
Chen X, Zhang L, Geng J, Chen Z, Cui X
Journal of oncology 2022;2022:8267891
Journal of oncology 2022;2022:8267891
KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis.
Zhang R, Ma L, Wei Y, Wei K, Song T, Du Z, Feng Z
BioMed research international 2022;2022:6000925
BioMed research international 2022;2022:6000925
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Liu WC, Chuang HC, Chou CL, Lee YH, Chiu YJ, Wang YL, Chiu HW
Oxidative medicine and cellular longevity 2022;2022:5696686
Oxidative medicine and cellular longevity 2022;2022:5696686
Chemoprevention of 4NQO-Induced Mouse Tongue Carcinogenesis by AKT Inhibitor through the MMP-9/RhoC Signaling Pathway and Autophagy.
Yin P, Chen J, Wu Y, Gao F, Wen J, Zhang W, Su Y, Zhang X
Analytical cellular pathology (Amsterdam) 2022;2022:3770715
Analytical cellular pathology (Amsterdam) 2022;2022:3770715
FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A.
Wang X, Li Y, Li Y, Liu P, Liu S, Pan Y
Stem cells international 2022;2022:3242482
Stem cells international 2022;2022:3242482
Rg1 Protects Hematopoietic Stem Cells from LiCl-Induced Oxidative Stress via Wnt Signaling Pathway.
Wang Z, Xia J, Li J, Chen L, Chen X, Zhang Y, Wang L, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2875583
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2875583
SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis.
Zhou X, Lin L, Qi Y, Xu M, Xu Q, Wang Y, Qu J
Disease markers 2022;2022:2562595
Disease markers 2022;2022:2562595
Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial-Mesenchymal Transition in Human Colorectal Cancer Cells.
Huang CY, Weng YT, Hsieh NT, Li PC, Lee TY, Li CI, Liu HS, Lee MF
BioMed research international 2022;2022:2268818
BioMed research international 2022;2022:2268818
1,25(OH)(2)D(3) Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway.
Wang JW, Zhu L, Shi PZ, Wang PC, Dai Y, Wang YX, Lu XH, Cheng XF, Feng XM, Zhang L
Oxidative medicine and cellular longevity 2022;2022:1427110
Oxidative medicine and cellular longevity 2022;2022:1427110
Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification.
Lin T, Yang WQ, Luo WW, Zhang LL, Mai YQ, Li ZQ, Liu ST, Jiang LJ, Liu PQ, Li ZM
Oxidative medicine and cellular longevity 2022;2022:1198607
Oxidative medicine and cellular longevity 2022;2022:1198607
HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle.
Zhang Z, Wu Q, Fang M, Liu Y, Jiang J, Feng Q, Hu R, Xu J
International journal of biological sciences 2022;18(8):3282-3297
International journal of biological sciences 2022;18(8):3282-3297
Aldolase A promotes cell proliferation and cisplatin resistance via the EGFR pathway in gastric cancer.
Gu M, Jiang B, Li H, Zhu D, Jiang Y, Xu W
American journal of translational research 2022;14(9):6586-6595
American journal of translational research 2022;14(9):6586-6595
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Luo J, Li L, Chang B, Zhu Z, Deng F, Hu M, Yu Y, Lu X, Chen Z, Zuo D, Zhou J
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways.
Chen X, Huang Y, Liu J, Lin W, Chen C, Chen Y, Ding Y, Yang Y, Chen Y, Wang H, Teng L
Journal of Cancer 2022;13(5):1456-1467
Journal of Cancer 2022;13(5):1456-1467
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Liu M, Hu T, Gou W, Chang H, Li Y, Li Y, Zuo D, Hou W, Jiao S
Frontiers in pharmacology 2022;13:993022
Frontiers in pharmacology 2022;13:993022
Metformin Improves the Senescence of Renal Tubular Epithelial Cells in a High-Glucose State Through E2F1.
Liang D, Li Z, Feng Z, Yuan Z, Dai Y, Wu X, Zhang F, Wang Y, Zhou Y, Liu L, Shi M, Xiao Y, Guo B
Frontiers in pharmacology 2022;13:926211
Frontiers in pharmacology 2022;13:926211
Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.
Wang X, Luo X, Gan X, Chen C, Yang Z, Wen J, Fang W, Huang H, Gao C, Zhou X, Feng X, Liu Y
Frontiers in pharmacology 2022;13:920554
Frontiers in pharmacology 2022;13:920554
Optineurin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration.
Hu Z, Wang Y, Gao X, Zhang Y, Liu C, Zhai Y, Chang X, Li H, Li Y, Lou J, Li C
Frontiers in pharmacology 2022;13:893307
Frontiers in pharmacology 2022;13:893307
Oridonin Delays Aging Through the AKT Signaling Pathway.
An Y, Zhu J, Wang X, Sun X, Luo C, Zhang Y, Ye Y, Li X, Abulizi A, Huang Z, Zhang H, Yang B, Xie Z
Frontiers in pharmacology 2022;13:888247
Frontiers in pharmacology 2022;13:888247
Chrysin Ameliorates Influenza Virus Infection in the Upper Airways by Repressing Virus-Induced Cell Cycle Arrest and Mitochondria-Dependent Apoptosis.
Liu Y, Song X, Li C, Hu H, Li W, Wang L, Hu J, Liao C, Liang H, He Z, Ye L
Frontiers in immunology 2022;13:872958
Frontiers in immunology 2022;13:872958
KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway.
Liao H, Zhang L, Lu S, Li W, Dong W
Frontiers in genetics 2022;13:848926
Frontiers in genetics 2022;13:848926
Identification and Validation of Ferroptosis-Related Biomarkers in Septic Cardiomyopathy via Bioinformatics Analysis.
Gong CW, Yuan MM, Qiu BQ, Wang LJ, Zou HX, Hu T, Lai SQ, Liu JC
Frontiers in genetics 2022;13:827559
Frontiers in genetics 2022;13:827559
Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging.
Lazzarini E, Lodrini AM, Arici M, Bolis S, Vagni S, Panella S, Rendon-Angel A, Saibene M, Metallo A, Torre T, Vassalli G, Ameri P, Altomare C, Rocchetti M, Barile L
Theranostics 2022;12(11):5237-5257
Theranostics 2022;12(11):5237-5257
Investigation of the inhibition effect of 1,2,3,4,6-pentagalloyl-β-D-glucose on gastric cancer cells based on a network pharmacology approach and experimental validation.
Bi JH, Jiang YH, Ye SJ, Wu MR, Yi Y, Wang HX, Wang LM
Frontiers in oncology 2022;12:934958
Frontiers in oncology 2022;12:934958
Knockdown of LMNB1 Inhibits the Proliferation of Lung Adenocarcinoma Cells by Inducing DNA Damage and Cell Senescence.
Li J, Sun Z, Cui Y, Qin L, Wu F, Li Y, Du N, Li X
Frontiers in oncology 2022;12:913740
Frontiers in oncology 2022;12:913740
Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma.
Zhu T, Wang T, Feng Z, Gao F, Zhang J, Jin C, Tian H, Xu J, Chen H, Ou Q, Wang J, Xu G, Lu L
Frontiers in oncology 2022;12:880100
Frontiers in oncology 2022;12:880100
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Wang H, Chen Y, Yuan Q, Chen L, Dai P, Li X
Frontiers in oncology 2022;12:1053510
Frontiers in oncology 2022;12:1053510
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Wang H, Cui Y, Gong H, Xu J, Huang S, Tang A
Frontiers in bioengineering and biotechnology 2022;10:929979
Frontiers in bioengineering and biotechnology 2022;10:929979
Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice.
Chen B, Zhu R, Hu H, Zhan M, Wang T, Huang F, Wei F, Chai Y, Ling Z, Zou X
Frontiers in cell and developmental biology 2022;10:853688
Frontiers in cell and developmental biology 2022;10:853688
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.
Zhang Z, Huang Y, Xu N, Wang J, Yao T, Xu Y, Qiao D, Gao J, Shen S, Ma J
Frontiers in cell and developmental biology 2022;10:819262
Frontiers in cell and developmental biology 2022;10:819262
PKC signal amplification suppresses non-small cell lung cancer growth by promoting p21 expression and phosphorylation.
Liu S, Zhang Y, Yang Q, Zhang Y, Liu H, Huang MH, Wang R, Lu F
Heliyon 2022 Sep;8(9):e10657
Heliyon 2022 Sep;8(9):e10657
Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure.
Long C, Liu H, Zhan W, Chen L, Yu Z, Tian S, Xiang Y, Chen S, Tian XL
Aging cell 2022 Sep;21(9):e13699
Aging cell 2022 Sep;21(9):e13699
Osteoblastic protein kinase D1 contributes to the prostate cancer cells dormancy via GAS6-circadian clock signaling.
Li G, Fan M, Zheng Z, Zhang Y, Zhang Z, Huang Z, Luo W, Zhao W, Lai X, Chen H, Zeng F, Deng F
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119296
Biochimica et biophysica acta. Molecular cell research 2022 Sep;1869(9):119296
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Luo L, Gong J, Wang Z, Liu Y, Cao J, Qin J, Zuo R, Zhang H, Wang S, Zhao P, Yang D, Zhang M, Wang Y, Zhang J, Zhou Y, Li C, Ni B, Tian Z, Liu M
Bioactive materials 2022 Sep;15:29-43
Bioactive materials 2022 Sep;15:29-43
Tetrahydroxy stilbene glucoside alters neurogenesis and neuroinflammation to ameliorate radiation-associated cognitive disability via AMPK/Tet2.
Miao BB, Gao D, Hao JP, Li YL, Li L, Wang JB, Xiao XH, Yang CC, Zhang L
International immunopharmacology 2022 Sep;110:108928
International immunopharmacology 2022 Sep;110:108928
Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.
Cabral VLF, Wang F, Peng X, Gao J, Zhou Z, Sun R, Bao J, Wu X
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Archives of gerontology and geriatrics 2022 Sep-Oct;102:104748
Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism.
Li P, Lin Q, Sun S, Yang N, Xia Y, Cao S, Zhang W, Li Q, Guo H, Zhu M, Wang Y, Zheng Z, Li S
Cell death & disease 2022 Sep 21;13(9):808
Cell death & disease 2022 Sep 21;13(9):808
Bisphenol A exposure causes testicular toxicity by targeting DPY30-mediated post-translational modification of PI3K/AKT signaling in mice.
He H, Li X, Shen J, Bai S, Li C, Shi H
Ecotoxicology and environmental safety 2022 Sep 15;243:113996
Ecotoxicology and environmental safety 2022 Sep 15;243:113996
Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence.
Cui X, Hao X, Wen J, Zhang S, Zhao B, Miao J
Genes 2022 Sep 14;13(9)
Genes 2022 Sep 14;13(9)
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
Zhang W, Yang X, Liu J, Pan Y, Zhang M, Chen L
Molecules (Basel, Switzerland) 2022 Sep 12;27(18)
Molecules (Basel, Switzerland) 2022 Sep 12;27(18)
In vitro and in vivo effects of hyperglycemia and diabetes mellitus on nucleus pulposus cell senescence.
Jiang Z, Jiang C, Jin L, Chen Z, Feng Z, Jiang X, Cao Y
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Oct;40(10):2350-2361
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Oct;40(10):2350-2361
Circadian clock gene BMAL1 inhibits the proliferation and tumor-formation ability of nasopharyngeal carcinoma cells and increases the sensitivity of radiotherapy.
Zhao C, Meng X, Li Y, Liu L, He Q, Jiang J, Chen Y, Li X, Li Y, Tang Y, Zhou D, Zhou J, Jin F
Chronobiology international 2022 Oct;39(10):1340-1351
Chronobiology international 2022 Oct;39(10):1340-1351
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.
Zhou S, Li P, Qin L, Huang S, Dang N
Experimental dermatology 2022 Oct;31(10):1563-1578
Experimental dermatology 2022 Oct;31(10):1563-1578
The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.
Wang L, Zhou Y, Cao C, Lin S, Zhi W, Zhang D, Li J, Wei R, Jiang G, Xu H, Wang X, Xi L, Wu P
Cancer medicine 2022 Oct;11(19):3657-3673
Cancer medicine 2022 Oct;11(19):3657-3673
ALG3 Promotes Peritoneal Metastasis of Ovarian Cancer through Increasing Interaction of α1,3-mannosylated uPAR and ADAM8.
Cui X, Pei X, Wang H, Feng P, Qin H, Liu S, Yan Q, Liu J
Cells 2022 Oct 6;11(19)
Cells 2022 Oct 6;11(19)
NOP53 undergoes liquid-liquid phase separation and promotes tumor radio-resistance.
Shi J, Chen SY, Shen XT, Yin XK, Zhao WW, Bai SM, Feng WX, Feng LL, Qin C, Zheng J, Wang YL, Fan XJ
Cell death discovery 2022 Oct 31;8(1):436
Cell death discovery 2022 Oct 31;8(1):436
An assembly-inducing PDC enabling the efficient nuclear delivery of nucleic acid for cancer stem-like cell suppression.
Wang D, Tian Y, Zhang Y, Sun X, Wu Y, Liu R, Zeng F, Du J, Hu K
Nanoscale 2022 Oct 27;14(41):15384-15392
Nanoscale 2022 Oct 27;14(41):15384-15392
RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability.
Jiang Z, Hao F, Zhu F, Yuan F, Ma L, Li G, Chen J, Tong T
Life sciences 2022 Oct 15;307:120848
Life sciences 2022 Oct 15;307:120848
RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway.
Xu J, Shi P, Xia F, Zhao X, Chen J, Geng R, Cui H, Yang L
International journal of molecular sciences 2022 Oct 10;23(19)
International journal of molecular sciences 2022 Oct 10;23(19)
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux.
Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M, Yang H, Xiao Y, Tu T, Tang L, Li X, Zeng J, Zheng X, Zhou S
Journal of advanced research 2022 Nov;41:205-218
Journal of advanced research 2022 Nov;41:205-218
Astragaloside IV alleviates senescence of vascular smooth muscle cells through activating Parkin-mediated mitophagy.
Li H, Xu J, Zhang Y, Hong L, He Z, Zeng Z, Zhang L
Human cell 2022 Nov;35(6):1684-1696
Human cell 2022 Nov;35(6):1684-1696
Identification of 3-Phenylquinoline Derivative PQ1 as an Antagonist of p53 Transcriptional Activity.
Wu X, Wang L, Li Z
ACS omega 2022 Nov 29;7(47):43180-43189
ACS omega 2022 Nov 29;7(47):43180-43189
Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells.
Huang TT, Chen CM, Lan YW, Lin SS, Choo KB, Chong KY
International journal of molecular sciences 2022 Nov 28;23(23)
International journal of molecular sciences 2022 Nov 28;23(23)
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells.
Chen L, Chen D, Li J, He L, Chen T, Song D, Shan S, Wang J, Lu X, Lu B
Cell death & disease 2022 Nov 28;13(11):1007
Cell death & disease 2022 Nov 28;13(11):1007
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F, Chun HJ, Song L, Hu J, Li Y
Biology direct 2022 Nov 16;17(1):32
Biology direct 2022 Nov 16;17(1):32
Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network.
Gao L, Yang WY, Qi H, Sun CJ, Qin XM, Du GH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153990
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153990
Dictamnine inhibits pancreatic cancer cell growth and epithelial-mesenchymal transition by blocking the PI3K/AKT signaling pathway.
Zhang ZQ, Xuan WL, Huang Y, Ren S, Wulan TY, Song Y, Xue DB, Zhang WH
Neoplasma 2022 May;69(3):603-619
Neoplasma 2022 May;69(3):603-619
Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster.
Fu R, Dou Z, Li N, Zhang J, Li Z, Yang P
Biochemical pharmacology 2022 May;199:115021
Biochemical pharmacology 2022 May;199:115021
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Wang J, Wang Y, Wang J, Zhang S, Yu Z, Zheng K, Fu Z, Wang C, Huang W, Chen J
Bioengineered 2022 May;13(5):13970-13985
Bioengineered 2022 May;13(5):13970-13985
Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma.
Zheng ZY, Chu MY, Lin W, Zheng YQ, Xu XE, Chen Y, Liao LD, Wu ZY, Wang SH, Li EM, Xu LY
Cell death & disease 2022 May 25;13(5):496
Cell death & disease 2022 May 25;13(5):496
Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Yuan K, Li Z, Kuang W, Wang X, Ji M, Chen W, Ding J, Li J, Min W, Sun C, Ye X, Lu M, Wang L, Ge H, Jiang Y, Hao H, Xiao Y, Yang P
Nature communications 2022 May 25;13(1):2903
Nature communications 2022 May 25;13(1):2903
Identification and validation of aging-related genes in COPD based on bioinformatics analysis.
Zhong S, Yang L, Liu N, Zhou G, Hu Z, Chen C, Wang Y
Aging 2022 May 24;14(10):4336-4356
Aging 2022 May 24;14(10):4336-4356
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer.
Cui H, Li H, Wu H, Du F, Xie X, Zeng S, Zhang Z, Dong K, Shang L, Jing C, Li L
Cell death & disease 2022 May 18;13(5):471
Cell death & disease 2022 May 18;13(5):471
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells.
Miao Y, Wan W, Zhu K, Pan M, Zhao X, Ma B, Wei Q
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
In vitro cellular & developmental biology. Animal 2022 Mar;58(3):220-231
USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.
Ren D, Sun Y, Li D, Wu H, Jin X
Molecular oncology 2022 Mar;16(5):1200-1217
Molecular oncology 2022 Mar;16(5):1200-1217
MiR-205-5p promotes lung cancer progression and is valuable for the diagnosis of lung cancer.
Zhao YL, Zhang JX, Yang JJ, Wei YB, Peng JF, Fu CJ, Huang MH, Wang R, Wang PY, Sun GB, Xie SY
Thoracic cancer 2022 Mar;13(6):832-843
Thoracic cancer 2022 Mar;13(6):832-843
TRIM21 deficiency promotes cell proliferation and tumorigenesis via regulating p21 expression in ovarian cancer.
Sun J, Chen X, Ji X, Meng S, Wang W, Wang P, Bai J, Li Z, Chen Y
Bioengineered 2022 Mar;13(3):6024-6035
Bioengineered 2022 Mar;13(3):6024-6035
Caveolin-1 Regulation and Function in Mouse Uterus during Early Pregnancy and under Human In Vitro Decidualization.
Song Z, Li B, Li M, Luo J, Hong Y, He Y, Chen S, Yang Z, Liang C, Yang Z
International journal of molecular sciences 2022 Mar 28;23(7)
International journal of molecular sciences 2022 Mar 28;23(7)
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I
BMC medicine 2022 Mar 28;20(1):95
BMC medicine 2022 Mar 28;20(1):95
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells.
Santarelli R, Pompili C, Gilardini Montani MS, Evangelista L, Gonnella R, Cirone M
Pharmaceutics 2022 Mar 17;14(3)
Pharmaceutics 2022 Mar 17;14(3)
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Guo H, Xiao Y, Yuan Z, Yang X, Chen J, Chen C, Wang M, Xie L, Chen Q, Tong Y, Zhang Q, Bai Y
Cell death discovery 2022 Mar 14;8(1):116
Cell death discovery 2022 Mar 14;8(1):116
PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence.
Singh CK, Denu RA, Nihal M, Shabbir M, Garvey DR, Huang W, Iczkowski KA, Ahmad N
The Prostate 2022 Jun;82(9):957-969
The Prostate 2022 Jun;82(9):957-969
The serum soluble Klotho alleviates cardiac aging and regulates M2a/M2c macrophage polarization via inhibiting TLR4/Myd88/NF-κB pathway.
Wang Y, Wang K, Bao Y, Zhang T, Ainiwaer D, Xiong X, Wang G, Sun Z
Tissue & cell 2022 Jun;76:101812
Tissue & cell 2022 Jun;76:101812
Comparative analysis of mouse embryonic palatal mesenchymal cells isolated by two primary culture methods.
Wang X, Peng X, Chen J, Wang Y, Zhao X, Li T, Du J
Tissue & cell 2022 Jun;76:101783
Tissue & cell 2022 Jun;76:101783
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary.
Hense JD, Garcia DN, Isola JV, Alvarado-Rincón JA, Zanini BM, Prosczek JB, Stout MB, Mason JB, Walsh PT, Brieño-Enríquez MA, Schadock I, Barros CC, Masternak MM, Schneider A
GeroScience 2022 Jun;44(3):1747-1759
GeroScience 2022 Jun;44(3):1747-1759
DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H(2)S in Diabetes.
Xi Y, Wen X, Zhang Y, Jiao L, Bai S, Shi S, Chang G, Wu R, Sun F, Hao J, Li H
Aging and disease 2022 Jun;13(3):910-926
Aging and disease 2022 Jun;13(3):910-926
Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis.
Bao X, Liu Y, Huang J, Yin S, Sheng H, Han X, Chen Q, Wang T, Chen S, Qiu Y, Zhang C, Yu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154066
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154066
CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis.
Hua J, Wang X, Ma L, Li J, Cao G, Zhang S, Lin W
Molecular cancer 2022 Jun 6;21(1):123
Molecular cancer 2022 Jun 6;21(1):123
ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, Wang F, Zhao G, Lü M, Cui H
Cell death & disease 2022 Jun 22;13(6):564
Cell death & disease 2022 Jun 22;13(6):564
Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis.
Zhu M, Min S, Mao X, Zhou Y, Zhang Y, Li W, Li L, Wu L, Cong X, Yu G
International journal of oral science 2022 Jun 20;14(1):29
International journal of oral science 2022 Jun 20;14(1):29
Downregulation of HINFP induces senescence-associated secretory phenotype to promote metastasis in a non-cell-autonomous manner in bladder cancer.
Zheng X, Liu Z, Zhong J, Zhou L, Chen J, Zheng L, Li Z, Zhang R, Pan J, Wu Y, Liu Z, Kang T
Oncogene 2022 Jul;41(28):3587-3598
Oncogene 2022 Jul;41(28):3587-3598
High expression of 14-3-3ơ indicates poor prognosis and progression of lung adenocarcinoma.
Feng J, Leng J, Zhao C, Guo J, Chen Y, Li H
Oncology letters 2022 Jul;24(1):203
Oncology letters 2022 Jul;24(1):203
Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis.
Lu W, Ren S, Dong W, Li X, Zheng Z, Jia Y, Xue Y
Acta biochimica et biophysica Sinica 2022 Jul 25;54(7):893-903
Acta biochimica et biophysica Sinica 2022 Jul 25;54(7):893-903
Aurora-A/FOXO3A/SKP2 axis promotes tumor progression in clear cell renal cell carcinoma and dual-targeting Aurora-A/SKP2 shows synthetic lethality.
Li P, Chen T, Kuang P, Liu F, Li Z, Liu F, Wang Y, Zhang W, Cai X
Cell death & disease 2022 Jul 13;13(7):606
Cell death & disease 2022 Jul 13;13(7):606
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling.
Zhou X, Wang W, Li Z, Chen L, Wen C, Ruan Q, Xu Z, Liu R, Xu J, Bai Y, Deng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153861
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy.
Sun J, Li Y, Yang X, Dong W, Yang J, Hu Q, Zhang C, Fang H, Liu A
Aging cell 2022 Jan;21(1):e13532
Aging cell 2022 Jan;21(1):e13532
Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion-Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency.
Ling L, Hou J, Wang Y, Shu H, Huang Y
Cell transplantation 2022 Jan-Dec;31:9636897221129171
Cell transplantation 2022 Jan-Dec;31:9636897221129171
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
CHMFL-BMX-078, a BMX inhibitor, overcomes the resistance of melanoma to vemurafenib via inhibiting AKT pathway.
Jiang S, Jiang T, Huang H, Chen X, Li L, Wang Z, Fei J, Liu C, Liu Z, Cheng Y
Chemico-biological interactions 2022 Jan 5;351:109747
Chemico-biological interactions 2022 Jan 5;351:109747
The Role of RAD6B and PEDF in Retinal Degeneration.
Ye Q, Wang J, Liu X, Liu Z, BaZong L, Ma J, Shen R, Ye W, Zhang W, Wang D
Neuroscience 2022 Jan 1;480:19-31
Neuroscience 2022 Jan 1;480:19-31
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Fan JH, Xu MM, Zhou LM, Gui ZW, Huang L, Li XG, Ye XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
SPOCK1 promotes metastasis in pancreatic cancer via NF-κB-dependent epithelial-mesenchymal transition by interacting with IκB-α.
Cui X, Wang Y, Lan W, Wang S, Cui Y, Zhang X, Lin Z, Piao J
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
Cellular oncology (Dordrecht, Netherlands) 2022 Feb;45(1):69-84
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Bai Z, Zhou Y, Ye X, Li Y, Peng Y, Guan Q, Zhang W, Ma L
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Chen X, Song QL, Ji R, Wang JY, Li ZH, Guo D, Yin TL, Wang SJ, Yang J
Placenta 2022 Feb;118:20-31
Placenta 2022 Feb;118:20-31
Heterozygous FMN2 missense variant found in a family case of premature ovarian insufficiency.
Li J, Peng T, Wang L, Long P, Quan R, Tan H, Zeng M, Wu X, Yang J, Xiao H, Shi X
Journal of ovarian research 2022 Feb 28;15(1):31
Journal of ovarian research 2022 Feb 28;15(1):31
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Liu H, Zhao D, Li H, Zhang W, Lin Q, Wang X, Zheng S, Zhang L, Li L, Hu S, Hu Y
Cell death & disease 2022 Feb 21;13(2):166
Cell death & disease 2022 Feb 21;13(2):166
Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells.
Zhang M, Peng R, Wang H, Yang Z, Zhang H, Zhang Y, Wang M, Wang H, Lin J, Zhao Q, Liu J
Cell death & disease 2022 Feb 17;13(2):159
Cell death & disease 2022 Feb 17;13(2):159
Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.
Zhang Y, Ma P, Duan Z, Liu Y, Mi Y, Fan D
International journal of molecular sciences 2022 Feb 11;23(4)
International journal of molecular sciences 2022 Feb 11;23(4)
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis.
Chang X, Liu Z, Cao S, Bian J, Zheng D, Wang N, Guan Q, Wu Y, Zhang W, Li Z, Zuo D
Toxicology and applied pharmacology 2022 Feb 1;436:115883
Toxicology and applied pharmacology 2022 Feb 1;436:115883
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
Xu M, Ren L, Fan J, Huang L, Zhou L, Li X, Ye X
Life sciences 2022 Feb 1;290:120266
Life sciences 2022 Feb 1;290:120266
Tetrahydroxy stilbene glycoside attenuates endothelial cell premature senescence induced by H(2)O(2) through the microRNA-34a/SIRT1 pathway.
Zhang L, Guo Y, Shi S, Zhuge Y, Chen N, Ding Z, Jin B
Scientific reports 2022 Feb 1;12(1):1708
Scientific reports 2022 Feb 1;12(1):1708
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
Jyothula SSK, Peters A, Liang Y, Bi W, Shivshankar P, Yau S, Garcha PS, Yuan X, Akkanti B, Collum S, Wareing N, Thandavarayan RA, Poli de Frias F, Rosas IO, Zhao B, Buja LM, Eltzschig HK, Huang HJ, Karmouty-Quintana H
EBioMedicine 2022 Dec;86:104351
EBioMedicine 2022 Dec;86:104351
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
He S, Zhou M, Zheng H, Wang Y, Wu S, Gao Y, Chen J
Renal failure 2022 Dec;44(1):171-183
Renal failure 2022 Dec;44(1):171-183
Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions.
Morita K, Nakamura A, Machida M, Kawasaki T, Nakanishi R, Ichida J, Iwata T, Umezawa A, Akutsu H
Regenerative therapy 2022 Dec;21:389-397
Regenerative therapy 2022 Dec;21:389-397
lncRNA NEAT1-let 7b-P21 axis mediates the proliferation of neural stem cells cultured in vitro promoted by radial extracorporeal shock wave.
Han K, Kang N, Yu X, Lu J, Ma Y
Regenerative therapy 2022 Dec;21:139-147
Regenerative therapy 2022 Dec;21:139-147
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Fu Z, Du H, Meng S, Yao M, Zhao P, Li X, Zheng X, Yuan Z, Yang H, Cai K, Dai L
Materials today. Bio 2022 Dec;16:100449
Materials today. Bio 2022 Dec;16:100449
Exogenous hydrogen sulfide inhibits the senescence of cardiomyocytes through modulating mitophagy in rats.
Hao J, Xi Y, Jiao L, Wen X, Wu R, Chang G, Sun F, Wei C, Li H
Cellular signalling 2022 Dec;100:110465
Cellular signalling 2022 Dec;100:110465
Canine Mammary Tumor Cell Lines Derived from Metastatic Foci Show Increased RAD51 Expression but Diminished Radioresistance via p21 Inhibition.
Shimakawa K, Ochiai K, Hirose S, Tanabe E, Michishita M, Sakaue M, Yoshikawa Y, Morimatsu M, Tajima T, Watanabe M, Tanaka Y
Veterinary sciences 2022 Dec 17;9(12)
Veterinary sciences 2022 Dec 17;9(12)
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Tan J, Sun M, Yin J, Zhou Q, Zhao R, Chen Q, Sun H, Jiang C, Li S, He Y
Chemico-biological interactions 2022 Dec 1;368:110208
Chemico-biological interactions 2022 Dec 1;368:110208
Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.
Zhang B, Liu ZY, Wu R, Zhang CM, Cao K, Shan WG, Liu Z, Ji M, Tian ZL, Sethi G, Shi HL, Wang RH
Acta pharmacologica Sinica 2022 Aug;43(8):2109-2118
Acta pharmacologica Sinica 2022 Aug;43(8):2109-2118
l-Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein-Barr virus-positive Burkitt lymphoma.
Sang W, Tu D, Zhang M, Qin Y, Yin W, Song X, Sun C, Yan D, Wang X, Zeng L, Li Z, Xu K, Xu L
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23117
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23117
Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy.
Huang Z, Gan S, Zhuang X, Chen Y, Lu L, Wang Y, Qi X, Feng Q, Huang Q, Du B, Zhang R, Liu Z
Cells 2022 Aug 9;11(16)
Cells 2022 Aug 9;11(16)
Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide.
Otte K, Zhao K, Braun M, Neubauer A, Raifer H, Helmprobst F, Barrera FO, Nimsky C, Bartsch JW, Rusch T
Biomedicines 2022 Aug 31;10(9)
Biomedicines 2022 Aug 31;10(9)
Long noncoding RNA HOXC-AS3 interacts with CDK2 to promote proliferation in hepatocellular carcinoma.
Su C, Wang W, Mo J, Liu F, Zhang H, Liu Y, Chen X, Liao Z, Zhang B, Zhu P
Biomarker research 2022 Aug 28;10(1):65
Biomarker research 2022 Aug 28;10(1):65
Alteration of E2F2 Expression in Governing Endothelial Cell Senescence.
Liu H, Chen L, Xiao W, Liu J, Long C, Zhan W, Cui C, Yang L, Chen S
Genes 2022 Aug 24;13(9)
Genes 2022 Aug 24;13(9)
Overexpression of MLF1IP promotes colorectal cancer cell proliferation through BRCA1/AKT/p27 signaling pathway.
Xu Y, Zhang L, Wang Q, Zheng M
Cellular signalling 2022 Apr;92:110273
Cellular signalling 2022 Apr;92:110273
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Zhang P, Gao K, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C
Cell death and differentiation 2022 Apr;29(4):758-771
Cell death and differentiation 2022 Apr;29(4):758-771
CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway.
Zhao N, Wang C, Guo P, Hou J, Yang H, Lan T, Zhou Y, Li J, Bhawal UK, Liu Y
Bioengineered 2022 Apr;13(4):10956-10972
Bioengineered 2022 Apr;13(4):10956-10972
HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC.
Zhang G, Zhu Q, Yan X, Ci M, Zhao E, Hou J, Wan S, Lü M, Cui H
Cell death discovery 2022 Apr 9;8(1):185
Cell death discovery 2022 Apr 9;8(1):185
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
Lu H, Yin H, Qu L, Ma X, Fu R, Fan D
Food & function 2022 Apr 4;13(7):3793-3811
Food & function 2022 Apr 4;13(7):3793-3811
ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity.
Xiao FH, Yu Q, Deng ZL, Yang K, Ye Y, Ge MX, Yan D, Wang HT, Chen XQ, Yang LQ, Yang BY, Lin R, Zhang W, Yang XL, Dong L, He Y, Zhou J, Cai WW, Li J, Kong QP
Science advances 2022 Apr 29;8(17):eabf2017
Science advances 2022 Apr 29;8(17):eabf2017
Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma.
Chen ZW, Hu JF, Wang ZW, Liao CY, Kang FP, Lin CF, Huang Y, Huang L, Tian YF, Chen S
Journal of experimental & clinical cancer research : CR 2022 Apr 23;41(1):153
Journal of experimental & clinical cancer research : CR 2022 Apr 23;41(1):153
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Yang Y, Liu S, He C, Lv T, Zeng L, Zhang F, Chen H, Zhao RC
Cell & bioscience 2022 Apr 21;12(1):45
Cell & bioscience 2022 Apr 21;12(1):45
The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors.
Liu W, Zhang B, Zhang D, Guo F, Ye K, Zhu L, Jin X
Cell death & disease 2022 Apr 2;13(4):295
Cell death & disease 2022 Apr 2;13(4):295
DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation.
Zhou Y, Yang Z, Zhang H, Li H, Zhang M, Wang H, Zhang M, Qiu P, Zhang R, Liu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Apr 1;1868(4):166353
Biochimica et biophysica acta. Molecular basis of disease 2022 Apr 1;1868(4):166353
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Song H, Zhuang L, Xu X, Shi J, Hu W, Liu Z, Shi S
Frontiers in medicine 2021;8:777563
Frontiers in medicine 2021;8:777563
PRRSV Promotes MARC-145 Cells Entry Into S Phase of the Cell Cycle to Facilitate Viral Replication via Degradation of p21 by nsp11.
Wen X, Ge X, Zhou L, Zhang Y, Guo X, Yang H
Frontiers in veterinary science 2021;8:642095
Frontiers in veterinary science 2021;8:642095
Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes.
Quinlan S, May S, Weeks R, Yuan H, Luff J
Frontiers in veterinary science 2021;8:570982
Frontiers in veterinary science 2021;8:570982
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Li X, He J, Li X, Li Y, Zhou Y, Cai S
Endokrynologia Polska 2021;72(6):634-642
Endokrynologia Polska 2021;72(6):634-642
In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion.
Li X, An M, Gao Z
Journal of oncology 2021;2021:7430468
Journal of oncology 2021;2021:7430468
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Zhang S, Zhang R, Qiao P, Ma X, Lu R, Wang F, Li C, E L, Liu H
Stem cells international 2021;2021:6616240
Stem cells international 2021;2021:6616240
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Han Y, Ma R, Cao G, Liu H, He L, Tang L, Li H, Luo Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.
Bai R, Yuan C, Sun W, Zhang J, Luo Y, Gao Y, Li Y, Gong Y, Xie C
International journal of biological sciences 2021;17(8):1995-2008
International journal of biological sciences 2021;17(8):1995-2008
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
Zhao S, Zhang Y, Lu X, Ding H, Han B, Song X, Miao H, Cui X, Wei S, Liu W, Chen S, Wang J
International journal of biological sciences 2021;17(13):3608-3621
International journal of biological sciences 2021;17(13):3608-3621
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Bai M, Cui M, Li M, Yao X, Wu Y, Zheng L, Sun L, Song Q, Wang S, Liu L, Yu C, Huang Y
International journal of biological sciences 2021;17(13):3493-3507
International journal of biological sciences 2021;17(13):3493-3507
Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells.
Astarita EM, Maloney SM, Spring CA, Berkeley BJ, VanKlompenberg MK, Nair TM, Prosperi JR
PloS one 2021;16(8):e0255738
PloS one 2021;16(8):e0255738
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J
Drug design, development and therapy 2021;15:1797-1810
Drug design, development and therapy 2021;15:1797-1810
Loss of DAB2IP Contributes to Cell Proliferation and Cisplatin Resistance in Gastric Cancer.
Wang G, Wang X, Han M, Wang X
OncoTargets and therapy 2021;14:979-988
OncoTargets and therapy 2021;14:979-988
Inhibition of mu-opioid receptor suppresses proliferation of hepatocellular carcinoma cells via CD147-p53-MAPK cascade signaling pathway.
Zhang JJ, Song CG, Dai JM, Zhang XQ, Lin P, Li L, Yang XM, Chen ZN
American journal of translational research 2021;13(5):3967-3986
American journal of translational research 2021;13(5):3967-3986
JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation.
Zhang B, Zhang Y, Jiang X, Su H, Wang Q, Wudu M, Jiang J, Ren H, Xu Y, Liu Z, Qiu X
Journal of Cancer 2021;12(4):976-987
Journal of Cancer 2021;12(4):976-987
N6-methyladenosine regulates ATM expression and downstream signaling.
Zhang X, Liu P, Zheng X, Wang J, Peng Q, Li Z, Wei L, Liu C, Wu Y, Wen Y, Yan Q, Ma J
Journal of Cancer 2021;12(23):7041-7051
Journal of Cancer 2021;12(23):7041-7051
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Fan S, Wang C, Huang K, Liang M
Frontiers in physiology 2021;12:790345
Frontiers in physiology 2021;12:790345
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.
Yang J, Wu Z, Yang L, Jeong JH, Zhu Y, Lu J, Wang B, Wang N, Wang Y, Shen K, Li R
Frontiers in pharmacology 2021;12:785981
Frontiers in pharmacology 2021;12:785981
Identifying the Key Genes in Mouse Liver Regeneration After Partial Hepatectomy by Bioinformatics Analysis and in vitro/vivo Experiments.
Zhao J, Yu SZ, Cai Q, Ma D, Jiang L, Yang LP, Yu ZY
Frontiers in genetics 2021;12:670706
Frontiers in genetics 2021;12:670706
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
Yang M, Li WY, Xie J, Wang ZL, Wen YL, Zhao CC, Tao L, Li LF, Tian Y, Sheng J
Frontiers in pharmacology 2021;12:639256
Frontiers in pharmacology 2021;12:639256
Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21(Cip1/WAF1).
Shi S, Li C, Zhang Y, Deng C, Tan M, Pan G, Du J, Ji Y, Li Q, Liang H, Liu W, Guo L, Zhao G, Liu Y, Cui H
American journal of cancer research 2021;11(4):1391-1409
American journal of cancer research 2021;11(4):1391-1409
Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
Cheng Y, Wang G, Zhao L, Dai S, Han J, Hu X, Zhou C, Wang F, Ma H, Li B, Meng Z
Frontiers in oncology 2021;11:753598
Frontiers in oncology 2021;11:753598
Long Non-Coding RNA CCAT2 Activates RAB14 and Acts as an Oncogene in Colorectal Cancer.
Wang D, Li Z, Yin H
Frontiers in oncology 2021;11:751903
Frontiers in oncology 2021;11:751903
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
Zhang D, Lu P, Zhu K, Wu H, Dai Y
Frontiers in oncology 2021;11:724437
Frontiers in oncology 2021;11:724437
Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis.
Zhang Y, Wang S, Chen Y, Zhang J, Yang J, Xian J, Li L, Zhao H, Hoffman RM, Zhang Y, Jia L
Frontiers in oncology 2021;11:666549
Frontiers in oncology 2021;11:666549
SNHG9, a Papillary Thyroid Cancer Cell Exosome-Enriched lncRNA, Inhibits Cell Autophagy and Promotes Cell Apoptosis of Normal Thyroid Epithelial Cell Nthy-ori-3 Through YBOX3/P21 Pathway.
Wen D, Liu WL, Lu ZW, Cao YM, Ji QH, Wei WJ
Frontiers in oncology 2021;11:647034
Frontiers in oncology 2021;11:647034
The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.
Sanches JGP, Song B, Zhang Q, Cui X, Yabasin IB, Ntim M, Li X, He J, Zhang Y, Mao J, Lu Y, Li L
Frontiers in oncology 2021;11:637298
Frontiers in oncology 2021;11:637298
PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma.
Liu Y, Chen H, Li X, Zhang F, Kong L, Wang X, Bai J, Wu X
Frontiers in oncology 2021;11:607021
Frontiers in oncology 2021;11:607021
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.
Zhang L, Zheng J, Tie X, Lin T, Yang W, Li Z, Zou Y, Guan G, Liu P, Luo W, Li Z
Canadian journal of physiology and pharmacology 2021 Sep;99(9):900-909
Canadian journal of physiology and pharmacology 2021 Sep;99(9):900-909
Kojic acid enhances the proliferation of human corneal epithelial cells via p38 and p21 signaling pathways.
Wei X, Du L, Sun L, Wang C, Song F, Qian H, Li X, Guo X, Tang X, Liu P
European journal of ophthalmology 2021 Sep;31(5):2287-2293
European journal of ophthalmology 2021 Sep;31(5):2287-2293
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
Welch N, Singh SS, Kumar A, Dhruba SR, Mishra S, Sekar J, Bellar A, Attaway AH, Chelluboyina A, Willard BB, Li L, Huo Z, Karnik SS, Esser K, Longworth MS, Shah YM, Davuluri G, Pal R, Dasarathy S
The Journal of biological chemistry 2021 Sep;297(3):101023
The Journal of biological chemistry 2021 Sep;297(3):101023
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas.
Wei QT, Liu BY, Ji HY, Lan YF, Tang WH, Zhou J, Zhong XY, Lian CL, Huang QZ, Wang CY, Xu YM, Guo HB
Molecular therapy oncolytics 2021 Sep 24;22:114-128
Molecular therapy oncolytics 2021 Sep 24;22:114-128
RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis.
Yu M, Hu X, Yan J, Wang Y, Lu F, Chang J
Biomedicines 2021 Sep 17;9(9)
Biomedicines 2021 Sep 17;9(9)
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Li L, Wang J, Feng L, Fan J, Wang J, Tan N, Wang Z
Journal of ethnopharmacology 2021 Sep 15;277:114184
Journal of ethnopharmacology 2021 Sep 15;277:114184
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
LncRNA ENSG00000254615 Modulates Proliferation and 5-FU Resistance by Regulating p21 and Cyclin D1 in Colorectal Cancer.
Fu Y, Huang R, Li J, Xie X, Deng Y
Cancer investigation 2021 Oct;39(9):696-710
Cancer investigation 2021 Oct;39(9):696-710
A novel histone deacetylase inhibitor LT-548-133-1 induces apoptosis by inhibiting HDAC and interfering with microtubule assembly in MCF-7 cells.
Xue J, Wu G, Ejaz U, Akhtar F, Wan X, Zhu Y, Geng A, Chen Y, He S
Investigational new drugs 2021 Oct;39(5):1222-1231
Investigational new drugs 2021 Oct;39(5):1222-1231
Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells.
Zhao A, Zhang J, Liu Y, Jia X, Lu X, Wang Q, Ji T, Yang L, Xue J, Gao R, Yu Y, Yang A
Translational oncology 2021 Oct;14(10):101172
Translational oncology 2021 Oct;14(10):101172
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
Zhang J, Zou L, Shi D, Liu J, Zhang J, Zhao R, Wang G, Zhang L, Ouyang L, Liu B
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
A novel mutation in PCK2 gene causes primary angle-closure glaucoma.
Xu M, Yang J, Sun J, Xing X, Liu Z, Liu T
Aging 2021 Oct 14;13(19):23338-23347
Aging 2021 Oct 14;13(19):23338-23347
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)
International journal of molecular sciences 2021 Oct 12;22(20)
Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells.
Wang L, Wang Y, Chen J, Yang XM, Jiang XT, Liu P, Li M
Ecotoxicology and environmental safety 2021 Oct 1;222:112472
Ecotoxicology and environmental safety 2021 Oct 1;222:112472
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
Song AN, Yin XJ, Gao P, Tang H, Meng XF, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
NEDD4L-induced ubiquitination mediating UBE2T degradation inhibits progression of lung adenocarcinoma via PI3K-AKT signaling.
Chen Y, Hong H, Wang Q, Li J, Zhang W, Chen T, Li P
Cancer cell international 2021 Nov 27;21(1):631
Cancer cell international 2021 Nov 27;21(1):631
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY
iScience 2021 Nov 19;24(11):103368
iScience 2021 Nov 19;24(11):103368
PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis.
Li Z, Wang D, Chen X, Wang W, Wang P, Hou P, Li M, Chu S, Qiao S, Zheng J, Bai J
Cell death & disease 2021 Nov 13;12(11):1080
Cell death & disease 2021 Nov 13;12(11):1080
Mitomycin induces alveolar epithelial cell senescence by down-regulating GSK3β signaling.
Xu X, Sun X, Wan X, Chen X, Jiang X
Toxicology letters 2021 Nov 1;352:61-69
Toxicology letters 2021 Nov 1;352:61-69
The whole profiling and competing endogenous RNA network analyses of noncoding RNAs in adipose-derived stem cells from diabetic, old, and young patients.
Ren S, Xiong H, Chen J, Yang X, Liu Y, Guo J, Jiang T, Xu Z, Yuan M, Liu Y, Zhou N, Chen H, Li W, Machens HG, Chen Z
Stem cell research & therapy 2021 May 29;12(1):313
Stem cell research & therapy 2021 May 29;12(1):313
LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
Huang Y, Lin Y, Song X, Wu D
Carcinogenesis 2021 May 28;42(5):733-741
Carcinogenesis 2021 May 28;42(5):733-741
Activity Components from Gynostemma pentaphyllum for Preventing Hepatic Fibrosis and of Its Molecular Targets by Network Pharmacology Approach.
Zhang Y, Shi G, Luo Z, Wang J, Wu S, Zhang X, Zhao Y
Molecules (Basel, Switzerland) 2021 May 18;26(10)
Molecules (Basel, Switzerland) 2021 May 18;26(10)
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation.
Jia M, Su B, Mo L, Qiu W, Ying J, Lin P, Yang B, Li D, Wang D, Xu L, Li H, Zhou Z, Li X, Li J
Oncology reports 2021 Mar;45(3):1033-1043
Oncology reports 2021 Mar;45(3):1033-1043
Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p.
Wu J, Li Y, Liu J, Xu Y
The journal of gene medicine 2021 Mar;23(3):e3293
The journal of gene medicine 2021 Mar;23(3):e3293
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Zhong H, Zhou Z, Guo L, Liu F, Zheng B, Bi S, Tian C
Mechanisms of ageing and development 2021 Mar;194:111417
Mechanisms of ageing and development 2021 Mar;194:111417
Two loss-of-function ANKRD11 variants in Chinese patients with short stature and a possible molecular pathway.
Zhang T, Yang Y, Yin X, Wang X, Ni J, Dong Z, Li C, Lu W
American journal of medical genetics. Part A 2021 Mar;185(3):710-718
American journal of medical genetics. Part A 2021 Mar;185(3):710-718
SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
Yang C, Hu JF, Zhan Q, Wang ZW, Li G, Pan JJ, Huang L, Liao CY, Huang Y, Tian YF, Shen BY, Chen JZ, Wang YD, Chen S
Genomics 2021 Mar;113(2):827-842
Genomics 2021 Mar;113(2):827-842
MYC promotes cancer progression by modulating m(6) A modifications to suppress target gene translation.
Wu G, Suo C, Yang Y, Shen S, Sun L, Li ST, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang YG, Cao J, Gao P
EMBO reports 2021 Mar 3;22(3):e51519
EMBO reports 2021 Mar 3;22(3):e51519
Morphologic Analysis of Urinary Podocytes in Focal Segmental Glomerulosclerosis.
Shirai Y, Miura K, Yokoyama T, Horita S, Nakayama H, Seino H, Ando T, Shiratori A, Yabuuchi T, Kaneko N, Ishiwa S, Ishizuka K, Hara M, Hattori M
Kidney360 2021 Mar 25;2(3):477-486
Kidney360 2021 Mar 25;2(3):477-486
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Wu H, Cui M, Li C, Li H, Dai Y, Cui K, Li Z
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy.
Chen L, Mei G, Jiang C, Cheng X, Li D, Zhao Y, Chen H, Wan C, Yao P, Gao C, Tang Y
Cell proliferation 2021 Jun;54(6):e13052
Cell proliferation 2021 Jun;54(6):e13052
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Jia R, Yang F, Yan P, Ma L, Yang L, Li L
Free radical biology & medicine 2021 Jun;169:158-168
Free radical biology & medicine 2021 Jun;169:158-168
Formin-like protein 2 promotes cell proliferation by a p27-related mechanism in human breast cancer cells.
Jiao X, Wang B, Feng C, Song S, Tian B, Zhou C, Gao X, Sun W, Liu P
BMC cancer 2021 Jun 30;21(1):760
BMC cancer 2021 Jun 30;21(1):760
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Dai C, Li H, Wang Y, Tang S, Velkov T, Shen J
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Zhao X, Jiang L, Hu D, Tang Y, Zhao G, Du X, Luo S, Tang W
Experimental cell research 2021 Jun 15;403(2):112614
Experimental cell research 2021 Jun 15;403(2):112614
The SESAME complex regulates cell senescence through the generation of acetyl-CoA.
Chen W, Yu X, Wu Y, Tang J, Yu Q, Lv X, Zha Z, Hu B, Li X, Chen J, Ma L, Workman JL, Li S
Nature metabolism 2021 Jul;3(7):983-1000
Nature metabolism 2021 Jul;3(7):983-1000
METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer.
Wang XK, Zhang YW, Wang CM, Li B, Zhang TZ, Zhou WJ, Cheng LJ, Huo MY, Zhang CH, He YL
Journal of cellular and molecular medicine 2021 Jul;25(14):6602-6617
Journal of cellular and molecular medicine 2021 Jul;25(14):6602-6617
Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation.
Osana S, Kitajima Y, Suzuki N, Nunomiya A, Takada H, Kubota T, Murayama K, Nagatomi R
Journal of cellular physiology 2021 Jul;236(7):5293-5305
Journal of cellular physiology 2021 Jul;236(7):5293-5305
Regulatory effect of microRNA-223-3p on breast cancer cell processes via the Hippo/Yap signaling pathway.
Du T, Wang D, Wan X, Xu J, Xiao Q, Liu B
Oncology letters 2021 Jul;22(1):516
Oncology letters 2021 Jul;22(1):516
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198
Cell death discovery 2021 Jul 29;7(1):198
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Liu J, He J, Ge L, Xiao H, Huang Y, Zeng L, Jiang Z, Lu M, Hu Z
Stem cell research & therapy 2021 Jul 22;12(1):413
Stem cell research & therapy 2021 Jul 22;12(1):413
Chemopreventive effects of pterostilbene through p53 and cell cycle in mouse lung of squamous cell carcinoma model.
Surien O, Ghazali AR, Masre SF
Scientific reports 2021 Jul 21;11(1):14862
Scientific reports 2021 Jul 21;11(1):14862
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
FOXO1 mediates hypoxia-induced G0/G1 arrest in ovarian somatic granulosa cells by activating the TP53INP1-p53-CDKN1A pathway.
Li C, Liu Z, Wu G, Zang Z, Zhang JQ, Li X, Tao J, Shen M, Liu H
Development (Cambridge, England) 2021 Jul 15;148(14)
Development (Cambridge, England) 2021 Jul 15;148(14)
Suppression of TCAB1 expression induced cellular senescence by lessening proteasomal degradation of p21 in cancer cells.
Niu J, Gao RQ, Cui MT, Zhang CG, Li ST, Cheng S, Ding W
Cancer cell international 2021 Jan 7;21(1):26
Cancer cell international 2021 Jan 7;21(1):26
Premature senescence of placental decidua cells as a possible cause of miscarriage produced by mycophenolic acid.
de la Torre P, Fernández-de la Torre M, Flores AI
Journal of biomedical science 2021 Jan 4;28(1):3
Journal of biomedical science 2021 Jan 4;28(1):3
The Interaction of the Senescent and Adjacent Breast Cancer Cells Promotes the Metastasis of Heterogeneous Breast Cancer Cells through Notch Signaling.
Zhang N, Ji J, Zhou D, Liu X, Zhang X, Liu Y, Xiang W, Wang M, Zhang L, Wang G, Huang B, Lu J, Zhang Y
International journal of molecular sciences 2021 Jan 15;22(2)
International journal of molecular sciences 2021 Jan 15;22(2)
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Wang X, Cheng G, Miao Y, Qiu F, Bai L, Gao Z, Huang Y, Dong L, Niu X, Wang X, Li Y, Tang H, Xu Y, Song X
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Zhang J, Yang S, Guan H, Zhou J, Gao Y
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.
Wu X, Yu M, Zhang Z, Leng F, Ma Y, Xie N, Lu F
Cell & bioscience 2021 Feb 8;11(1):34
Cell & bioscience 2021 Feb 8;11(1):34
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G
Cell death & disease 2021 Feb 4;12(2):150
Cell death & disease 2021 Feb 4;12(2):150
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
Lyu G, Su P, Hao X, Chen S, Ren S, Zhao Z, Gong Y, Liu Q, Shao C
Cancer biology & medicine 2021 Feb 15;18(1):120-138
Cancer biology & medicine 2021 Feb 15;18(1):120-138
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.
Zeng L, Li A, Zhang Z, Zhang F, Chen H, Wang Y, Ding X, Luo H
Inflammation 2021 Dec;44(6):2362-2376
Inflammation 2021 Dec;44(6):2362-2376
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, Xie L, Chen J, Guo D, Wu J, Li CM
Virologica Sinica 2021 Dec;36(6):1411-1420
Virologica Sinica 2021 Dec;36(6):1411-1420
Ubiquitination of p21 by E3 Ligase TRIM21 Promotes the Proliferation of Human Neuroblastoma Cells.
Wang F, Wu Z, Li Q, Ni Z, Wang C, Lu J
Neuromolecular medicine 2021 Dec;23(4):549-560
Neuromolecular medicine 2021 Dec;23(4):549-560
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Chen YX, Wang CJ, Xiao DS, He BM, Li M, Yi XP, Zhang W, Yin JY, Liu ZQ
Pharmacological research 2021 Dec;174:105934
Pharmacological research 2021 Dec;174:105934
(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.
Chen C, Wang YS, Zhang ET, Li GA, Liu WY, Li Y, Jin YH
International journal of molecular sciences 2021 Dec 6;22(23)
International journal of molecular sciences 2021 Dec 6;22(23)
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Zhu X, Yang H, Zhang M, Wu X, Jiang L, Liu X, Lv K
Cancer cell international 2021 Dec 4;21(1):645
Cancer cell international 2021 Dec 4;21(1):645
Fumonisin B(1) Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells.
Li Q, Yuan Q, Wang T, Zhan Y, Yang L, Fan Y, Lei H, Su J
Toxins 2021 Dec 3;13(12)
Toxins 2021 Dec 3;13(12)
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y, Zhao L
Oncogenesis 2021 Dec 3;10(12):84
Oncogenesis 2021 Dec 3;10(12):84
Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway.
Shi PZ, Wang JW, Wang PC, Han B, Lu XH, Ren YX, Feng XM, Cheng XF, Zhang L
World journal of stem cells 2021 Dec 26;13(12):1928-1946
World journal of stem cells 2021 Dec 26;13(12):1928-1946
PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer.
Xu Y, Liu J, Jiang T, Shi L, Shang L, Song J, Li L
Experimental cell research 2021 Dec 15;409(2):112924
Experimental cell research 2021 Dec 15;409(2):112924
Dlx5 promotes cancer progression through regulation of CCND1 in oral squamous cell carcinoma (OSCC).
Zhang J, Wu J, Chen Y, Zhang W
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Aug;99(4):424-434
Biochemistry and cell biology = Biochimie et biologie cellulaire 2021 Aug;99(4):424-434
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Cheng Y, Hu Y, Wang H, Zhao Z, Jiang X, Zhang Y, Zhang J, Tong Y, Qiu X
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, Wang L, Gong Z
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Chang L, Zhou R, He Y, Meng M, Hu J, Liu Y, Pan Y, Tang Z, Yue Z
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Liao X, Wu C, Shao Z, Zhang S, Zou Y, Wang K, Ha Y, Xing J, Zheng A, Shen Z, Zheng S, Guo J, Jie W
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
Liu X, Gu Y, Bian Y, Cai D, Li Y, Zhao Y, Zhang Z, Xue M, Zhang L
Apoptosis : an international journal on programmed cell death 2021 Apr;26(3-4):195-208
Apoptosis : an international journal on programmed cell death 2021 Apr;26(3-4):195-208
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Chen CC, Chen J, Wang WL, Xie L, Shao CQ, Zhang YX
Orthopaedic surgery 2021 Apr;13(2):583-591
Orthopaedic surgery 2021 Apr;13(2):583-591
Identification and characterization of R2TP in the development of oral squamous cell carcinoma.
Kiguchi T, Kakihara Y, Yamazaki M, Katsura K, Izumi K, Tanuma JI, Saku T, Takagi R, Saeki M
Biochemical and biophysical research communications 2021 Apr 9;548:161-166
Biochemical and biophysical research communications 2021 Apr 9;548:161-166
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723
Aging 2021 Apr 6;13(7):10703-10723
Anti-tumor activity of a novel proteasome inhibitor D395 against multiple myeloma and its lower cardiotoxicity compared with carfilzomib.
Shen X, Wu C, Lei M, Yan Q, Zhang H, Zhang L, Wang X, Yang Y, Li J, Zhu Y, Chen L
Cell death & disease 2021 Apr 30;12(5):429
Cell death & disease 2021 Apr 30;12(5):429
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Tan YZ, Xu XY, Dai JM, Yin Y, He XT, Zhang YL, Zhu TX, An Y, Tian BM, Chen FM
Stem cell research & therapy 2021 Apr 29;12(1):254
Stem cell research & therapy 2021 Apr 29;12(1):254
Hybrid-cell membrane-coated nanocomplex-loaded chikusetsusaponin IVa methyl ester for a combinational therapy against breast cancer assisted by Ce6.
Xie Q, Liu Y, Long Y, Wang Z, Jiang S, Ahmed R, Daniyal M, Li B, Liu B, Wang W
Biomaterials science 2021 Apr 21;9(8):2991-3004
Biomaterials science 2021 Apr 21;9(8):2991-3004
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Chen J, Zhang W, Pan C, Fan J, Zhong X, Tang S
Life sciences 2021 Apr 15;271:119185
Life sciences 2021 Apr 15;271:119185
CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer.
Chen S, Yang C, Wang ZW, Hu JF, Pan JJ, Liao CY, Zhang JQ, Chen JZ, Huang Y, Huang L, Zhan Q, Tian YF, Shen BY, Wang YD
Journal of hematology & oncology 2021 Apr 13;14(1):60
Journal of hematology & oncology 2021 Apr 13;14(1):60
Safrana l Prevents Prostate Cancer Recurrence by Blocking the Re-activation of Quiescent Cancer Cells via Downregulation of S-Phase Kinase-Associated Protein 2.
Jiang X, Li Y, Feng JL, Nik Nabil WN, Wu R, Lu Y, Liu H, Xi ZC, Xu HX
Frontiers in cell and developmental biology 2020;8:598620
Frontiers in cell and developmental biology 2020;8:598620
THAP11 Functions as a Tumor Suppressor in Gastric Cancer through Regulating c-Myc Signaling Pathways.
Zhang J, Zhang H, Shi H, Wang F, Du J, Wang Y, Wei Y, Xue W, Li D, Feng Y, Yan J, Gao Y, Li J, Han J
BioMed research international 2020;2020:7838924
BioMed research international 2020;2020:7838924
Enhanced Effect of IL-1β-Activated Adipose-Derived MSCs (ADMSCs) on Repair of Intestinal Ischemia-Reperfusion Injury via COX-2-PGE(2) Signaling.
Liu L, He YR, Liu SJ, Hu L, Liang LC, Liu DL, Liu L, Zhu ZQ
Stem cells international 2020;2020:2803747
Stem cells international 2020;2020:2803747
Skp2 modulates proliferation, senescence and tumorigenesis of glioma.
Wu J, Su HK, Yu ZH, Xi SY, Guo CC, Hu ZY, Qu Y, Cai HP, Zhao YY, Zhao HF, Chen FR, Huang YF, To ST, Feng BH, Sai K, Chen ZP, Wang J
Cancer cell international 2020;20:71
Cancer cell international 2020;20:71
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
Li K, Zhao S, Long J, Su J, Wu L, Tao J, Zhou J, Zhang J, Chen X, Peng C
Cancer cell international 2020;20:36
Cancer cell international 2020;20:36
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Xu W, Huang M, Guo J, Zhang H, Wang D, Liu T, Liu H, Chen S, Gao P, Mu K
International journal of biological sciences 2020;16(8):1388-1402
International journal of biological sciences 2020;16(8):1388-1402
HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells.
Auclair M, Guénantin AC, Fellahi S, Garcia M, Capeau J
PloS one 2020;15(1):e0226924
PloS one 2020;15(1):e0226924
Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma.
Lin Z, Qu S, Peng W, Yang P, Zhang R, Zhang P, Guo D, Du J, Wu W, Tao K, Wang J
OncoTargets and therapy 2020;13:51-60
OncoTargets and therapy 2020;13:51-60
NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway.
Zhang X, Wang H, Han Y, Zhu M, Song Z, Zhan D, Jia J
OncoTargets and therapy 2020;13:11315-11326
OncoTargets and therapy 2020;13:11315-11326
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
Li X, Huang W, Huang W, Wei T, Zhu W, Chen G, Zhang J
American journal of translational research 2020;12(5):1614-1639
American journal of translational research 2020;12(5):1614-1639
A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.
Lv Z, Wu K, Qin X, Yuan J, Yan M, Zhang J, Wang L, Ji T, Cao W, Chen W
Cancer management and research 2020;12:4855-4869
Cancer management and research 2020;12:4855-4869
Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells.
Zhang YY, Luo LM, Wang YX, Zhu N, Zhao TJ, Qin L
Journal of Cancer 2020;11(14):4261-4273
Journal of Cancer 2020;11(14):4261-4273
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853
Theranostics 2020;10(15):6839-6853
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Deficiency of Grx1 leads to high sensitivity of HeLaS3 cells to oxidative stress via excessive accumulation of intracellular oxidants including ROS.
Zhao T, Zhang-Akiyama QM
Free radical research 2020 Sep;54(8-9):585-605
Free radical research 2020 Sep;54(8-9):585-605
E2F7, regulated by miR‑30c, inhibits apoptosis and promotes cell cycle of prostate cancer cells.
Wang Y, Pei X, Xu P, Tan Z, Zhu Z, Zhang G, Jiang Z, Deng Z
Oncology reports 2020 Sep;44(3):849-862
Oncology reports 2020 Sep;44(3):849-862
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
Wang X, Li D, Wu H, Liu F, Liu F, Zhang Q, Li J
Mechanisms of ageing and development 2020 Sep;190:111293
Mechanisms of ageing and development 2020 Sep;190:111293
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074
Bioorganic chemistry 2020 Sep;102:104074
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Dai GH, Chen X, Ren ZM, Dai CJ, Tong YL, Chai KQ
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway.
Yang Y, Wang Q, Song D, Zen R, Zhang L, Wang Y, Yang H, Zhang D, Jia J, Zhang J, Wang J
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
Journal of experimental & clinical cancer research : CR 2020 Sep 22;39(1):197
UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.
Gu C, Zhao K, Zhou N, Liu F, Xie F, Yu S, Feng Y, Chen L, Yang J, Tian F, Jiang G
Cell death & disease 2020 Sep 10;11(9):733
Cell death & disease 2020 Sep 10;11(9):733
Paris polyphylla ethanol extract induces G2/M arrest and suppresses migration and invasion in bladder cancer.
Liu Z, Sun Z, Zhang D, Ma C, Jiang Y, Cao G, Sun C, Li K, Xu D, Liu J, Zhao S
Translational cancer research 2020 Oct;9(10):5994-6004
Translational cancer research 2020 Oct;9(10):5994-6004
Azidothymidine (AZT) Inhibits Proliferation of Human Ovarian Cancer Cells by Regulating Cell Cycle Progression.
Hsieh Y, Tseng JJ
Anticancer research 2020 Oct;40(10):5517-5527
Anticancer research 2020 Oct;40(10):5517-5527
Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.
Sun Q, Ye Z, Qin Y, Fan G, Ji S, Zhuo Q, Xu W, Liu W, Hu Q, Liu M, Zhang Z, Xu X, Yu X
Oncogene 2020 Oct;39(42):6572-6588
Oncogene 2020 Oct;39(42):6572-6588
KIF15 contributes to cell proliferation and migration in breast cancer.
Gao X, Zhu L, Lu X, Wang Y, Li R, Jiang G
Human cell 2020 Oct;33(4):1218-1228
Human cell 2020 Oct;33(4):1218-1228
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Zhu MJ, Liu BY, Shi L, Wang X, Wang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells.
Zhu X, Chen T, Yang H, Lv K
Journal of cellular and molecular medicine 2020 Oct;24(20):11691-11702
Journal of cellular and molecular medicine 2020 Oct;24(20):11691-11702
SLC25A10 performs an oncogenic role in human osteosarcoma.
Wang G, Xia J, Chen C, Qiu J, Sun P, Peng Z, Chen X, Xu B
Oncology letters 2020 Oct;20(4):2
Oncology letters 2020 Oct;20(4):2
Minichromosome maintenance protein 5 is an important pathogenic factor of oral squamous cell carcinoma.
Hao M, Wang H, Zhang C, Li C, Wang X
Oncology letters 2020 Oct;20(4):109
Oncology letters 2020 Oct;20(4):109
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, Jin X, Jiang L, Lou Y, Qiu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Loss of RAD6B induces degeneration of the cochlea in mice.
Ma Y, Song Y, Shen R, Li P, Ding H, Guo Z, Liu X, Wang D
Biochemical and biophysical research communications 2020 Oct 20;531(3):402-408
Biochemical and biophysical research communications 2020 Oct 20;531(3):402-408
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Lin J, Xu R, Shen X, Jiang H, Du S
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Epidermal ROCK2 induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma.
Masre SF, Rath N, Olson MF, Greenhalgh DA
Carcinogenesis 2020 Oct 15;41(10):1409-1420
Carcinogenesis 2020 Oct 15;41(10):1409-1420
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Yu ZY, Jiang XY, Zhao RR, Luo CJ, Ren YX, Ma ZJ, Ye HL, Shi WG, Wang C, Jiao ZY
Neoplasma 2020 Nov;67(6):1303-1313
Neoplasma 2020 Nov;67(6):1303-1313
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Song Z, Guo Q, Wang H, Gao L, Wang S, Liu D, Liu J, Qi Y, Lin B
Pathology, research and practice 2020 Nov;216(11):153148
Pathology, research and practice 2020 Nov;216(11):153148
Effect of sodium butyrate on ABC transporters in lung cancer A549 and colorectal cancer HCT116 cells.
Shi B, Xu FF, Xiang CP, Jia R, Yan CH, Ma SQ, Wang N, Wang AJ, Fan P
Oncology letters 2020 Nov;20(5):148
Oncology letters 2020 Nov;20(5):148
Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.
Guan Y, Jiang S, Ye W, Ren X, Wang X, Zhang Y, Yin M, Wang K, Tao Y, Yang J, Cao D, Cheng Y
Cell death & disease 2020 Nov 3;11(11):948
Cell death & disease 2020 Nov 3;11(11):948
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Wei M, Xie M, Zhang Z, Wei Y, Zhang J, Pan H, Li B, Wang J, Song Y, Chong C, Zhao R, Wang J, Yu L, Yang G, Yang C
European journal of medicinal chemistry 2020 Nov 15;206:112677
European journal of medicinal chemistry 2020 Nov 15;206:112677
A translational program that suppresses metabolism to shield the genome.
Balukoff NC, Ho JJD, Theodoridis PR, Wang M, Bokros M, Llanio LM, Krieger JR, Schatz JH, Lee S
Nature communications 2020 Nov 13;11(1):5755
Nature communications 2020 Nov 13;11(1):5755
Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit.
Ma C, Wang X, Yang F, Zang Y, Liu J, Wang X, Xu X, Li W, Jia J, Liu Z
Molecular cancer 2020 Nov 10;19(1):157
Molecular cancer 2020 Nov 10;19(1):157
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
Wang N, Liu H, Liu G, Li M, He X, Yin C, Tu Q, Shen X, Bai W, Wang Q, Tao Y, Yin H
Redox biology 2020 May;32:101495
Redox biology 2020 May;32:101495
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
Jia Y, Jin H, Gao L, Yang X, Wang F, Ding H, Chen A, Tan S, Zhang F, Shao J, Wang S, Zheng S
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316
Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways.
Hu Z, Long T, Ma Y, Zhu J, Gao L, Zhong Y, Wang X, Wang X, Li Z
Journal of experimental & clinical cancer research : CR 2020 May 5;39(1):76
Journal of experimental & clinical cancer research : CR 2020 May 5;39(1):76
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
Li T, Wu S, Jia L, Cao W, Yao Y, Zhao G, Li H
Cancer biology & medicine 2020 May 15;17(2):357-370
Cancer biology & medicine 2020 May 15;17(2):357-370
LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer.
Jin X, Ge LP, Li DQ, Shao ZM, Di GH, Xu XE, Jiang YZ
Molecular cancer 2020 May 11;19(1):87
Molecular cancer 2020 May 11;19(1):87
SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression.
Cao N, Yu Y, Zhu H, Chen M, Chen P, Zhuo M, Mao Y, Li L, Zhao Q, Wu M, Ye M
Cell death & disease 2020 May 11;11(5):351
Cell death & disease 2020 May 11;11(5):351
Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.
Chen JJ, Sun X, Mao QQ, Jiang XY, Zhao XG, Xu WJ, Zhong L
The Kaohsiung journal of medical sciences 2020 Mar;36(3):196-205
The Kaohsiung journal of medical sciences 2020 Mar;36(3):196-205
Identification of apoptosis-associated protein factors distinctly expressed in cigarette smoke condensate-exposed airway bronchial epithelial cells.
Lin BC, Li QY, Tian L, Liu HL, Liu XH, Shi Y, He C, Ding SS, Yan J, Li K, Bian LP, Lai WQ, Zhang W, Li X, Xi ZG
Journal of biochemical and molecular toxicology 2020 Mar;34(3):e22444
Journal of biochemical and molecular toxicology 2020 Mar;34(3):e22444
Decreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions.
Li F, Zhao F, Li M, Pan M, Shi F, Xu H, Zheng D, Wang L, Dou J
Journal of cellular physiology 2020 Mar;235(3):2183-2194
Journal of cellular physiology 2020 Mar;235(3):2183-2194
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.
Zhang Y, Cui N, Zheng G
Oncology letters 2020 Mar;19(3):1975-1984
Oncology letters 2020 Mar;19(3):1975-1984
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB
PLoS pathogens 2020 Mar;16(3):e1008429
PLoS pathogens 2020 Mar;16(3):e1008429
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
BRCA1 protects cardiac microvascular endothelial cells against irradiation by regulating p21-mediated cell cycle arrest.
Zeng ZM, Du HY, Xiong L, Zeng XL, Zhang P, Cai J, Huang L, Liu AW
Life sciences 2020 Mar 1;244:117342
Life sciences 2020 Mar 1;244:117342
MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway.
Pan S, Wu W, Ren F, Li L, Li Y, Li W, Wang A, Liu D, Dong Y
Life sciences 2020 Mar 1;244:117300
Life sciences 2020 Mar 1;244:117300
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
Dou Y, Huang D, Zeng X, Zhou Y, Jiang X, Yue C, He J, Xiao S
Biotechnology letters 2020 Jun;42(6):1051-1060
Biotechnology letters 2020 Jun;42(6):1051-1060
Inhibition of PIM1 attenuates the stem cell-like traits of breast cancer cells by promoting RUNX3 nuclear retention.
Liu H, Chen C, Ma D, Li Y, Yin Q, Li Q, Xiang C
Journal of cellular and molecular medicine 2020 Jun;24(11):6308-6323
Journal of cellular and molecular medicine 2020 Jun;24(11):6308-6323
Baicalein suppresses the proliferation and invasiveness of colorectal cancer cells by inhibiting Snail‑induced epithelial‑mesenchymal transition.
Zeng Q, Zhang Y, Zhang W, Guo Q
Molecular medicine reports 2020 Jun;21(6):2544-2552
Molecular medicine reports 2020 Jun;21(6):2544-2552
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma.
Chu YD, Lin WR, Lin YH, Kuo WH, Tseng CJ, Lim SN, Huang YL, Huang SC, Wu TJ, Lin KH, Yeh CT
Cancers 2020 Jun 22;12(6)
Cancers 2020 Jun 22;12(6)
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
Liu H, Zhang W, Fang Y, Yang H, Tian L, Li K, Lai W, Bian L, Lin B, Liu X, Xi Z
Journal of hazardous materials 2020 Jun 15;392:122312
Journal of hazardous materials 2020 Jun 15;392:122312
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.
Honda Y, Huang A, Tanaka T, Han X, Gao B, Liu H, Wang X, Zhao J, Hashimoto Y, Yamamoto K, Matsumoto N, Baba S, Umeda M
International journal of molecular sciences 2020 Jun 13;21(12)
International journal of molecular sciences 2020 Jun 13;21(12)
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Li Y, Shi H, Yuan J, Qiao L, Dong L, Wang Y
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1291-1300
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1291-1300
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, Shi L, Song D
Cancer medicine 2020 Jan;9(2):724-736
Cancer medicine 2020 Jan;9(2):724-736
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Liu L, Wang F, Tong Y, Li LF, Liu Y, Gao WQ
Cell proliferation 2020 Jan;53(1):e12718
Cell proliferation 2020 Jan;53(1):e12718
LINC00511 contributes to glioblastoma tumorigenesis and epithelial-mesenchymal transition via LINC00511/miR-524-5p/YB1/ZEB1 positive feedback loop.
Du X, Tu Y, Liu S, Zhao P, Bao Z, Li C, Li J, Pan M, Ji J
Journal of cellular and molecular medicine 2020 Jan;24(2):1474-1487
Journal of cellular and molecular medicine 2020 Jan;24(2):1474-1487
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways.
Li Y, Chen F, Chen J, Chan S, He Y, Liu W, Zhang G
Cancers 2020 Jan 6;12(1)
Cancers 2020 Jan 6;12(1)
EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.
Zhao H, Wang Y, Yang C, Zhou J, Wang L, Yi K, Li Y, Wang Q, Shi J, Kang C, Zeng L
Clinical and translational medicine 2020 Jan 28;9(1):10
Clinical and translational medicine 2020 Jan 28;9(1):10
miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5.
Wu J, Lu K, Zhu M, Xie X, Ding Y, Shao X, Chen Y, Liu J, Xu M, Xu Y, Zhou J, Shen X, Zhu C
Biochemical and biophysical research communications 2020 Jan 22;521(4):984-990
Biochemical and biophysical research communications 2020 Jan 22;521(4):984-990
CARLo-5 as an oncogenic gene in endometrial carcinoma.
Zhao X, Zhang C, Wei X, Shi L, Dai S, Jia J, Wei S, Wang Y, Wang Y, Cheng J, Zhao L
Environmental and molecular mutagenesis 2020 Feb;61(2):256-265
Environmental and molecular mutagenesis 2020 Feb;61(2):256-265
Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, Xu Y, Cui Y, Liu Y, Zhang J
FEBS letters 2020 Feb;594(3):497-508
FEBS letters 2020 Feb;594(3):497-508
Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Wang S, Wang H, Sun B, Li D, Wu J, Li J, Tian X, Qin C, Chang H, Liu Y
Fundamental & clinical pharmacology 2020 Feb;34(1):65-76
Fundamental & clinical pharmacology 2020 Feb;34(1):65-76
Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.
Zhao J, Han Y, Wang Z, Zhang R, Wang G, Mao Y
Biotechnology letters 2020 Dec;42(12):2749-2758
Biotechnology letters 2020 Dec;42(12):2749-2758
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
Qingjie Fuzheng Granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via Sonic Hedgehog pathway.
Zhu XQ, Yang H, Lin MH, Shang HX, Peng J, Chen WJ, Chen XZ, Lin JM
Journal of gastrointestinal oncology 2020 Dec;11(6):1123-1134
Journal of gastrointestinal oncology 2020 Dec;11(6):1123-1134
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Postprandial triglyceride-rich lipoproteins-induced premature senescence of adipose-derived mesenchymal stem cells via the SIRT1/p53/Ac-p53/p21 axis through oxidative mechanism.
Xiang QY, Tian F, Du X, Xu J, Zhu LY, Guo LL, Wen T, Liu YS, Liu L
Aging 2020 Dec 9;12(24):26080-26094
Aging 2020 Dec 9;12(24):26080-26094
SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling.
Xu M, Zhang X, Zhang S, Piao J, Yang Y, Wang X, Lin Z
Aging 2020 Dec 3;13(1):1032-1050
Aging 2020 Dec 3;13(1):1032-1050
siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation.
Osana S, Kitajima Y, Suzuki N, Xu Y, Murayama K, Nagatomi R
Experimental cell research 2020 Dec 1;397(1):112337
Experimental cell research 2020 Dec 1;397(1):112337
Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling.
Hussain F, Basu S, Heng JJH, Loo LH, Zink D
Archives of toxicology 2020 Aug;94(8):2749-2767
Archives of toxicology 2020 Aug;94(8):2749-2767
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Ma Y, Yan R, Wan Q, Lv B, Yang Y, Lv T, Xin W
Journal of physiology and biochemistry 2020 Aug;76(3):373-382
Journal of physiology and biochemistry 2020 Aug;76(3):373-382
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, Han L, Xin X, Wang H, Lin D, Peng F, Yu F, Zheng C, Shen C
Cell proliferation 2020 Aug;53(8):e12869
Cell proliferation 2020 Aug;53(8):e12869
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, Chen P, Williamson RA, Wang B, Hu J
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038
Biochemical pharmacology 2020 Aug;178:114038
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.
Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, Malley BWO, Fares F, Zhang B, Li X, Li L, Xiao J
Nature communications 2020 Aug 6;11(1):3904
Nature communications 2020 Aug 6;11(1):3904
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Liu JR, Cai GY, Ning YC, Wang JC, Lv Y, Guo YN, Fu B, Hong Q, Sun XF, Chen XM
Aging 2020 Aug 27;12(18):18052-18072
Aging 2020 Aug 27;12(18):18052-18072
The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.
Ullah K, Chen S, Lu J, Wang X, Liu Q, Zhang Y, Long Y, Hu Z, Xu G
The Journal of biological chemistry 2020 Apr 3;295(14):4696-4708
The Journal of biological chemistry 2020 Apr 3;295(14):4696-4708
Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways.
Yu ZY, Jiang XY, Zhao RR, Qin JJ, Luo CJ, Ren YX, Ren W, Ma ZJ, Jiao ZY
Chinese medical journal 2020 Apr 20;133(8):919-928
Chinese medical journal 2020 Apr 20;133(8):919-928
Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.
Pereira EJ, Burns JS, Lee CY, Marohl T, Calderon D, Wang L, Atkins KA, Wang CC, Janes KA
Science signaling 2020 Apr 14;13(627)
Science signaling 2020 Apr 14;13(627)
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.
Zhao Z, Li L, Du P, Ma L, Zhang W, Zheng L, Lan B, Zhang B, Ma F, Xu B, Zhan Q, Song Y
Theranostics 2019;9(5):1401-1416
Theranostics 2019;9(5):1401-1416
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S
Frontiers in oncology 2019;9:1325
Frontiers in oncology 2019;9:1325
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Wu Z, Chen D, Wang K, Cao C, Xu X
Frontiers in oncology 2019;9:1260
Frontiers in oncology 2019;9:1260
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
Li Y, Li X, Cao M, Jiang Y, Yan J, Liu Z, Yang R, Chen X, Sun P, Xiang R, Wang L, Shi Y
Signal transduction and targeted therapy 2019;4:50
Signal transduction and targeted therapy 2019;4:50
LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro.
Wang X, Jin Q, Wang X, Chen W, Cai Z
Cancer biomarkers : section A of Disease markers 2019;26(2):171-182
Cancer biomarkers : section A of Disease markers 2019;26(2):171-182
Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
Cui D, Zhao Y, Xu J
Cancer biology & therapy 2019;20(5):608-616
Cancer biology & therapy 2019;20(5):608-616
MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.
Fan X, Wang Y, Song J, Wu H, Yang M, Lu L, Weng X, Liu L, Nie G
Cancer biology & therapy 2019;20(10):1328-1336
Cancer biology & therapy 2019;20(10):1328-1336
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582
International journal of medical sciences 2019;16(12):1573-1582
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL, Wang YX
OncoTargets and therapy 2019;12:8105-8115
OncoTargets and therapy 2019;12:8105-8115
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
Ye Z, Zeng Z, Shen Y, Yang Q, Chen D, Chen Z, Shen S
OncoTargets and therapy 2019;12:4081-4092
OncoTargets and therapy 2019;12:4081-4092
Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma.
Qin H, Li Y, Zhang H, Wang F, He H, Bai X, Li S
OncoTargets and therapy 2019;12:1917-1927
OncoTargets and therapy 2019;12:1917-1927
Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway.
Liu H, Feng XD, Yang B, Tong RL, Lu YJ, Chen DY, Zhou L, Xie HY, Zheng SS, Wu J
American journal of translational research 2019;11(8):4713-4725
American journal of translational research 2019;11(8):4713-4725
A combination of low-dose decitabine and chidamide resulted in synergistic effects on the proliferation and apoptosis of human myeloid leukemia cell lines.
Xu F, Guo H, Shi M, Liu S, Wei M, Sun K, Chen Y
American journal of translational research 2019;11(12):7644-7655
American journal of translational research 2019;11(12):7644-7655
HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer.
Li F, Su M, Zhao H, Xie W, Cao S, Xu Y, Chen W, Wang L, Hou L, Tan W
American journal of translational research 2019;11(11):7035-7048
American journal of translational research 2019;11(11):7035-7048
UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma.
Liu LL, Zhu JM, Yu XN, Zhu HR, Shi X, Bilegsaikhan E, Guo HY, Wu J, Shen XZ
Cancer management and research 2019;11:8359-8370
Cancer management and research 2019;11:8359-8370
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
Xin C, Lu S, Li Y, Zhang Y, Tian J, Zhang S, Yang S, Gao T, Xu J
DNA and cell biology 2019 Sep;38(9):996-1004
DNA and cell biology 2019 Sep;38(9):996-1004
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4
Gastroenterology 2019 Sep;157(3):744-759.e4
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression.
Sun S, Hu Z, Huang S, Ye X, Wang J, Chang J, Wu X, Wang Q, Zhang L, Hu X, Yu H
Journal of cancer research and clinical oncology 2019 Sep;145(9):2273-2283
Journal of cancer research and clinical oncology 2019 Sep;145(9):2273-2283
MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.
Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, Hu Y, Wu G, Dong X
Aging 2019 Sep 8;11(17):6734-6761
Aging 2019 Sep 8;11(17):6734-6761
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, Zhao H, Ke J, Wu S, Wang X, Wu F
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.
Zheng F, Wang M, Li Y, Huang C, Tao D, Xie F, Zhang H, Sun J, Zhang C, Gu C, Wang Z, Jiang G
Cancer letters 2019 Sep 28;460:139-151
Cancer letters 2019 Sep 28;460:139-151
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y
European journal of medicinal chemistry 2019 Sep 15;178:177-194
European journal of medicinal chemistry 2019 Sep 15;178:177-194
Exosomal Notch3 from high glucose-stimulated endothelial cells regulates vascular smooth muscle cells calcification/aging.
Lin X, Li S, Wang YJ, Wang Y, Zhong JY, He JY, Cui XJ, Zhan JK, Liu YS
Life sciences 2019 Sep 1;232:116582
Life sciences 2019 Sep 1;232:116582
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner.
He J, Hong B, Bian M, Jin H, Chen J, Shao J, Zhang F, Zheng S
International immunopharmacology 2019 Oct;75:105816
International immunopharmacology 2019 Oct;75:105816
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z
Cancer research and treatment 2019 Oct;51(4):1653-1665
Cancer research and treatment 2019 Oct;51(4):1653-1665
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)
Life science alliance 2019 Oct;2(5)
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, Shen W, Zhong M
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.
Liu Y, Fan D
Biochemical pharmacology 2019 Oct;168:285-304
Biochemical pharmacology 2019 Oct;168:285-304
RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer.
Zhang Z, Li X, Han Y, Ji T, Huang X, Gao Q, Ma D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109341
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109341
Conditioned medium derived from human amniotic stem cells delays H2O2‑induced premature senescence in human dermal fibroblasts.
Pan C, Lang H, Zhang T, Wang R, Lin X, Shi P, Zhao F, Pang X
International journal of molecular medicine 2019 Nov;44(5):1629-1640
International journal of molecular medicine 2019 Nov;44(5):1629-1640
Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.
Li Y, Zu X, Hu X, Wang L, He W
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 25;25:8928-8939
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 25;25:8928-8939
Self-Assembled saRNA Delivery System Based on Rolling Circle Transcription for Aptamer-Targeting Cancer Therapy.
Wang T, Hong S, Luo Y, Lv H, Zhang Y, Pei R
ACS applied bio materials 2019 Nov 18;2(11):4737-4746
ACS applied bio materials 2019 Nov 18;2(11):4737-4746
Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.
Peng W, Tong C, Li L, Huang C, Ran Y, Chen X, Bai Y, Liu Y, Zhao J, Tan B, Luo X, Wang H, Wen L, Zhang C, Zhang H, Ding Y, Qi H, Baker PN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6327-6338
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6327-6338
Upregulation of lncRNA DGCR5 correlates with better prognosis and inhibits bladder cancer progression via transcriptionally facilitating P21 expression.
Fang C, He W, Xu T, Dai J, Xu L, Sun F
Journal of cellular physiology 2019 May;234(5):6254-6262
Journal of cellular physiology 2019 May;234(5):6254-6262
NF-κB inhibition promotes apoptosis in androgen-independent prostate cancer cells by the photothermal effect via the IκBα/AR signaling pathway.
Kong C, Hao M, Chen X, Zhao X, Wang Y, Li J, Gao Y, Zhang H, Yang B, Jiang J
Biomaterials science 2019 May 28;7(6):2559-2570
Biomaterials science 2019 May 28;7(6):2559-2570
Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract.
Yan Y, Yu H, Sun L, Liu H, Wang C, Wei X, Song F, Li H, Ge H, Qian H, Li X, Tang X, Liu P
Aging 2019 May 10;11(9):2699-2723
Aging 2019 May 10;11(9):2699-2723
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
Liang X, Ding Y, Lin F, Zhang Y, Zhou X, Meng Q, Lu X, Jiang G, Zhu H, Chen Y, Lian Q, Fan H, Liu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):4559-4570
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):4559-4570
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Wei X, Luo D, Yan Y, Yu H, Sun L, Wang C, Song F, Ge H, Qian H, Li X, Tang X, Liu P
Experimental eye research 2019 Mar;180:174-183
Experimental eye research 2019 Mar;180:174-183
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, Liu Y, Fan S, Li Z, Xiong W, Li X, Ren C, Tan M, Li G, Zhou M
Cancer science 2019 Mar;110(3):939-949
Cancer science 2019 Mar;110(3):939-949
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW
Journal of translational medicine 2019 Mar 7;17(1):72
Journal of translational medicine 2019 Mar 7;17(1):72
The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma.
Sun X, Xie Y, Sun X, Yao Y, Li H, Li Z, Yao R, Xu K
Bioscience reports 2019 Mar 29;39(3)
Bioscience reports 2019 Mar 29;39(3)
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, Gan S, Ha Y, He Z, Jie W
BMC cancer 2019 Mar 22;19(1):262
BMC cancer 2019 Mar 22;19(1):262
SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride.
Gu X, Wang Z, Gao J, Han D, Zhang L, Chen P, Luo G, Han B
Toxicology in vitro : an international journal published in association with BIBRA 2019 Jun;57:28-38
Toxicology in vitro : an international journal published in association with BIBRA 2019 Jun;57:28-38
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
Liu R, Xu X, Liang C, Chen X, Yu X, Zhong H, Xu W, Cheng Y, Wang W, Wu Y, Yu L, Hu X
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
Three kinds of corneal host cells contribute differently to corneal neovascularization.
Yu H, Sun L, Cui J, Li Y, Yan Y, Wei X, Wang C, Song F, Jiang W, Liu Y, Ge H, Qian H, Li X, Tang X, Liu P
EBioMedicine 2019 Jun;44:542-553
EBioMedicine 2019 Jun;44:542-553
Potent and specific MTH1 inhibitors targeting gastric cancer.
Zhou W, Ma L, Yang J, Qiao H, Li L, Guo Q, Ma J, Zhao L, Wang J, Jiang G, Wan X, Adam Goscinski M, Ding L, Zheng Y, Li W, Liu H, Suo Z, Zhao W
Cell death & disease 2019 Jun 4;10(6):434
Cell death & disease 2019 Jun 4;10(6):434
miR-384-5p Targets Gli2 and Negatively Regulates Age-Related Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells.
Li X, Wu J, Liu S, Zhang K, Miao X, Li J, Shi Z, Gao Y
Stem cells and development 2019 Jun 15;28(12):791-798
Stem cells and development 2019 Jun 15;28(12):791-798
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Wang SY, Wang WJ, Liu JQ, Song YH, Li P, Sun XF, Cai GY, Chen XM
Cell cycle (Georgetown, Tex.) 2019 Jul;18(14):1573-1587
Cell cycle (Georgetown, Tex.) 2019 Jul;18(14):1573-1587
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop.
Yang B, Wu A, Hu Y, Tao C, Wang JM, Lu Y, Xing R
Journal of experimental & clinical cancer research : CR 2019 Jul 1;38(1):283
Journal of experimental & clinical cancer research : CR 2019 Jul 1;38(1):283
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
Effect of ingredients from Chinese herbs on enterovirus D68 production.
Meng X, Yu X, Liu C, Wang Y, Song F, Huan C, Huo W, Zhang S, Li Z, Zhang J, Zhang W, Yu J
Phytotherapy research : PTR 2019 Jan;33(1):174-186
Phytotherapy research : PTR 2019 Jan;33(1):174-186
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.
Lin X, Zhan JK, Zhong JY, Wang YJ, Wang Y, Li S, He JY, Tan P, Chen YY, Liu XB, Cui XJ, Liu YS
Aging 2019 Jan 17;11(2):523-535
Aging 2019 Jan 17;11(2):523-535
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q
EBioMedicine 2019 Feb;40:92-105
EBioMedicine 2019 Feb;40:92-105
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, Wang Q, Su H, Jiang X, Dao R, Qiu X
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Guo J, Tang Q, Wang Q, Sun W, Pu Z, Wang J, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
CircCDYL inhibits the expression of C-MYC to suppress cell growth and migration in bladder cancer.
Sun J, Zhang H, Tao D, Xie F, Liu F, Gu C, Wang M, Wang L, Jiang G, Wang Z, Xiao X
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):1349-1356
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):1349-1356
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer.
Xue Y, Lian W, Zhi J, Yang W, Li Q, Guo X, Gao J, Qu H, Lin W, Li Z, Lai L, Wang Q
British journal of cancer 2019 Dec;121(12):1039-1049
British journal of cancer 2019 Dec;121(12):1039-1049
Bone secreted factors induce cellular quiescence in prostate cancer cells.
Yu-Lee LY, Lee YC, Pan J, Lin SC, Pan T, Yu G, Hawke DH, Pan BF, Lin SH
Scientific reports 2019 Dec 9;9(1):18635
Scientific reports 2019 Dec 9;9(1):18635
Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.
Zhao J, Honda Y, Tanaka T, Hashimoto Y, Matsumoto N
Materials (Basel, Switzerland) 2019 Dec 23;13(1)
Materials (Basel, Switzerland) 2019 Dec 23;13(1)
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C
Oncogene 2019 Aug;38(33):6142-6157
Oncogene 2019 Aug;38(33):6142-6157
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Sui A, Xu Y, Pan B, Guo T, Wu J, Shen Y, Yang J, Guo X
Journal of cellular physiology 2019 Aug;234(10):17990-17998
Journal of cellular physiology 2019 Aug;234(10):17990-17998
Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.
Zheng M, Tian C, Fan T, Xu B
Experimental eye research 2019 Aug;185:107681
Experimental eye research 2019 Aug;185:107681
Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.
Que Z, Zhou Z, Luo B, Dong C, Jiang Y, Li H, Tian J
BMC complementary and alternative medicine 2019 Aug 7;19(1):204
BMC complementary and alternative medicine 2019 Aug 7;19(1):204
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Pan JH, Zhou H, Zhu SB, Huang JL, Zhao XX, Ding H, Qin L, Pan YL
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Journal of cellular physiology 2019 Apr;234(4):4385-4395
NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats.
Chen L, He PL, Yang J, Yang YF, Wang K, Amend B, Stenzl A, Zhang YM, Wang ZL, Xing SS, Luo X
Molecular medicine reports 2019 Apr;19(4):2960-2968
Molecular medicine reports 2019 Apr;19(4):2960-2968
YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21(Waf1/Cip1).
Sui Y, Wu T, Li F, Wang F, Cai Y, Jin J
International journal of molecular sciences 2019 Apr 28;20(9)
International journal of molecular sciences 2019 Apr 28;20(9)
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
Wang Z, Wang Y, Wang S, Meng X, Song F, Huo W, Zhang S, Chang J, Li J, Zheng B, Liu Y, Zhang Y, Zhang W, Yu J
Frontiers in cellular and infection microbiology 2018;8:279
Frontiers in cellular and infection microbiology 2018;8:279
SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer.
Li Z, Qiu R, Qiu X, Tian T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(2):463-478
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(2):463-478
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
Liu X, Zhao Y, Zhang W, Gao Y, Huo M, Liu M, Xiao Z, Liang S, Xu N, Zhu H
OncoTargets and therapy 2018;11:3087-3100
OncoTargets and therapy 2018;11:3087-3100
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
Ling Z, Guan H, You Z, Wang C, Hu L, Zhang L, Wang Y, Chen S, Xu B, Chen M
OncoTargets and therapy 2018;11:2735-2743
OncoTargets and therapy 2018;11:2735-2743
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
Badi I, Mancinelli L, Polizzotto A, Ferri D, Zeni F, Burba I, Milano G, Brambilla F, Saccu C, Bianchi ME, Pompilio G, Capogrossi MC, Raucci A
Arteriosclerosis, thrombosis, and vascular biology 2018 Sep;38(9):2079-2090
Arteriosclerosis, thrombosis, and vascular biology 2018 Sep;38(9):2079-2090
The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin.
Ding J, Yu C, Sui Y, Wang L, Yang Y, Wang F, Yao H, Xing F, Liu H, Li Y, Shah JA, Cai Y, Jin J
The FEBS journal 2018 Sep;285(17):3270-3285
The FEBS journal 2018 Sep;285(17):3270-3285
Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma.
Bao Y, Zhang S, Guo Y, Wei X, Zhang Y, Yang Y, Zhang H, Ma M, Yang W
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018 Sep;20(9):1185-1195
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018 Sep;20(9):1185-1195
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Xing SS, Li J, Chen L, Yang YF, He PL, Li J, Yang J
Mechanisms of ageing and development 2018 Oct;175:1-6
Mechanisms of ageing and development 2018 Oct;175:1-6
Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.
Xie F, Li Y, Wang M, Huang C, Tao D, Zheng F, Zhang H, Zeng F, Xiao X, Jiang G
Molecular cancer 2018 Oct 3;17(1):144
Molecular cancer 2018 Oct 3;17(1):144
The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo.
Yu M, Wang H, Liu J, Qin H, Liu S, Yan Q
FEBS letters 2018 Nov;592(22):3696-3707
FEBS letters 2018 Nov;592(22):3696-3707
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy.
Wen W, Chen J, Ding L, Luo X, Zheng X, Dai Q, Gu Q, Liu C, Liang M, Guo X, Liu P, Li M
Archives of biochemistry and biophysics 2018 Nov 1;657:31-40
Archives of biochemistry and biophysics 2018 Nov 1;657:31-40
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, Qiao L, Ling Q, Liu S, Zhao Y
Molecular medicine reports 2018 May;17(5):6551-6559
Molecular medicine reports 2018 May;17(5):6551-6559
Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcoma.
Ye P, Ke X, Zang X, Sun H, Dong Z, Lin J, Wang L, Liu W, Miao G, Tan Y, Tong W, Xiao H, Gao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 May;101:219-227
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 May;101:219-227
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Yang F, Yi M, Liu Y, Wang Q, Hu Y, Deng H
Journal of proteome research 2018 Mar 2;17(3):1091-1100
Journal of proteome research 2018 Mar 2;17(3):1091-1100
Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice.
Uesato T, Ogihara T, Hara A, Iida H, Miyatsuka T, Fujitani Y, Takeda S, Watada H
Journal of the Endocrine Society 2018 Mar 1;2(3):207-219
Journal of the Endocrine Society 2018 Mar 1;2(3):207-219
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, Liu X, Zhong M, Xie D, Huang W, Jia W, Li S, Liu X, Zuo X, Cheng D, Dai J, Ren C
International journal of oncology 2018 Jun;52(6):1787-1800
International journal of oncology 2018 Jun;52(6):1787-1800
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.
Jiang B, Zhao W, Shi M, Zhang J, Chen A, Ma H, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, Liu M, Wen S, Ouyang C, Wang H, Huang X, Zhou H, Li Q
The Journal of biological chemistry 2018 Jun 22;293(25):9747-9758
The Journal of biological chemistry 2018 Jun 22;293(25):9747-9758
[Infiltrating mast cells promote neuroendocrine differentiation and increase docetaxel resistance of prostate cancer cells by up-regulating p21].
Ou YH, Jiang YD, Li Q, Zhuang YJ, Dang Q, Tan WL
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018 Jun 20;38(6):723-730
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018 Jun 20;38(6):723-730
Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention.
Wang J, Chen J, Jiang Y, Shi Y, Zhu J, Xie C, Geng S, Wu J, Zhang Q, Wang X, Meng Y, Li Y, Chen Y, Cao W, Wang X, Zhong C, Li X
Toxicology letters 2018 Jul;291:70-76
Toxicology letters 2018 Jul;291:70-76
Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy.
Napoli E, Song G, Panoutsopoulos A, Riyadh MA, Kaushik G, Halmai J, Levenson R, Zarbalis KS, Giulivi C
Scientific reports 2018 Jul 27;8(1):11348
Scientific reports 2018 Jul 27;8(1):11348
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, Li Z, Li F, Jiang J, Liu P, Li Z
Aging 2018 Jul 24;10(7):1722-1744
Aging 2018 Jul 24;10(7):1722-1744
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Wang W, Cai G, Chen X
Experimental gerontology 2018 Jul 1;107:4-10
Experimental gerontology 2018 Jul 1;107:4-10
NF-κB/miR-223-3p/ARID1A axis is involved in Helicobacter pylori CagA-induced gastric carcinogenesis and progression.
Yang F, Xu Y, Liu C, Ma C, Zou S, Xu X, Jia J, Liu Z
Cell death & disease 2018 Jan 9;9(1):12
Cell death & disease 2018 Jan 9;9(1):12
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Zhang J, Yuan JP, Wang Q, Shao LH, Liu SP, Firestone RA, Hong YP, Li JG, Xin YC, Li Y
Oncotarget 2018 Jan 5;9(2):1957-1968
Oncotarget 2018 Jan 5;9(2):1957-1968
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
Zhang W, Yao F, Zhang H, Li N, Zou X, Sui L, Hou L
International journal of molecular sciences 2018 Jan 2;19(1)
International journal of molecular sciences 2018 Jan 2;19(1)
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Zhang ZF, Zhang HR, Zhang QY, Lai SY, Feng YZ, Zhou Y, Zheng SR, Shi R, Zhou JY
Journal of translational medicine 2018 Jan 19;16(1):9
Journal of translational medicine 2018 Jan 19;16(1):9
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
Liu A, Guo E, Yang J, Yang Y, Liu S, Jiang X, Hu Q, Dirsch O, Dahmen U, Zhang C, Gewirtz DA, Fang H
Aging cell 2018 Feb;17(1)
Aging cell 2018 Feb;17(1)
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
Yang HW, Hong HL, Luo WW, Dai CM, Chen XY, Wang LP, Li Q, Li ZQ, Liu PQ, Li ZM
Acta pharmacologica Sinica 2018 Dec;39(12):1837-1846
Acta pharmacologica Sinica 2018 Dec;39(12):1837-1846
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
Cancer science 2018 Dec;109(12):3762-3773
Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer.
Chen M, Zhang H, Zhang G, Zhong A, Ma Q, Kai J, Tong Y, Xie S, Wang Y, Zheng H, Guo L, Lu R
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):74-82
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):74-82
A pH probe inhibits senescence in mesenchymal stem cells.
Wang L, Han X, Qu G, Su L, Zhao B, Miao J
Stem cell research & therapy 2018 Dec 7;9(1):343
Stem cell research & therapy 2018 Dec 7;9(1):343
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH
Cancers 2018 Dec 31;11(1)
Cancers 2018 Dec 31;11(1)
S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells.
Fan Y, Mao Y, Cao S, Xia G, Zhang Q, Zhang H, Qiu F, Kang N
Molecules (Basel, Switzerland) 2018 Dec 1;23(12)
Molecules (Basel, Switzerland) 2018 Dec 1;23(12)
Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.
Chen SM, Lin TK, Tseng YY, Tu CH, Lui TN, Huang SF, Hsieh LL, Li YY
Cancer medicine 2018 Aug;7(8):3988-4003
Cancer medicine 2018 Aug;7(8):3988-4003
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S, Guan F
Cell and tissue research 2018 Aug;373(2):379-393
Cell and tissue research 2018 Aug;373(2):379-393
Suppressed epithelial-mesenchymal transition and cancer stem cell properties mediate the anti-cancer effects of ethyl pyruvate via regulation of the AKT/nuclear factor-κB pathway in prostate cancer cells.
Huang B, Lv DJ, Wang C, Shu FP, Gong ZC, Xie T, Yu YZ, Song XL, Xie JJ, Li S, Liu YM, Qi H, Zhao SC
Oncology letters 2018 Aug;16(2):2271-2278
Oncology letters 2018 Aug;16(2):2271-2278
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Wu F, Li S, Zhang N, Huang W, Li X, Wang M, Bai D, Han B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma.
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K
Bioscience reports 2018 Aug 31;38(4)
Bioscience reports 2018 Aug 31;38(4)
Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A.
Xue X, Wang X, Zhao Y, Hu R, Qin L
Biochemical and biophysical research communications 2018 Aug 25;502(4):515-521
Biochemical and biophysical research communications 2018 Aug 25;502(4):515-521
Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation.
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K
Molecules (Basel, Switzerland) 2018 Apr 30;23(5)
Molecules (Basel, Switzerland) 2018 Apr 30;23(5)
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Histone deacetylase inhibitor NaBut suppresses cell proliferation and induces apoptosis by targeting p21 in multiple myeloma.
Yao R, Han D, Sun X, Fu C, Wu Q, Yao Y, Li H, Li Z, Xu K
American journal of translational research 2017;9(11):4994-5002
American journal of translational research 2017;9(11):4994-5002
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, Wang Y, Wei C, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2017;7:67
Cell & bioscience 2017;7:67
H(2)S Donor NaHS Changes the Production of Endogenous H(2)S and NO in D-Galactose-Induced Accelerated Ageing.
Wu W, Hou CL, Mu XP, Sun C, Zhu YC, Wang MJ, Lv QZ
Oxidative medicine and cellular longevity 2017;2017:5707830
Oxidative medicine and cellular longevity 2017;2017:5707830
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.
Chong D, Ma L, Liu F, Zhang Z, Zhao S, Huo Q, Zhang P, Zheng H, Liu H
Anti-cancer drugs 2017 Sep;28(8):831-840
Anti-cancer drugs 2017 Sep;28(8):831-840
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W
Oncotarget 2017 Sep 22;8(37):61846-61860
Oncotarget 2017 Sep 22;8(37):61846-61860
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
Bolduan S, Koppensteiner H, Businger R, Rebensburg S, Kunze C, Brack-Werner R, Draenert R, Schindler M
Journal of the International AIDS Society 2017 Sep 19;20(1):21865
Journal of the International AIDS Society 2017 Sep 19;20(1):21865
A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms.
Lu HY, Huang CY, Shih CM, Lin YW, Tsai CS, Lin FY, Shih CC
Journal of vascular surgery 2017 Oct;66(4):1217-1226.e1
Journal of vascular surgery 2017 Oct;66(4):1217-1226.e1
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554
Scientific reports 2017 Oct 19;7(1):13554
Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest.
Zhang J, Wen X, Liu N, Li YQ, Tang XR, Wang YQ, He QM, Yang XJ, Zhang PP, Ma J, Sun Y
Journal of experimental & clinical cancer research : CR 2017 Oct 19;36(1):147
Journal of experimental & clinical cancer research : CR 2017 Oct 19;36(1):147
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
Yao X, Tang H, Ren Q, Zhao X, Zuo H, Li Z
Oncotarget 2017 Nov 7;8(55):94197-94209
Oncotarget 2017 Nov 7;8(55):94197-94209
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Zhao W, Lu D, Liu L, Cai J, Zhou Y, Yang Y, Zhang Y, Zhang J
Oncotarget 2017 Nov 7;8(55):93672-93687
Oncotarget 2017 Nov 7;8(55):93672-93687
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
TRPC5 channel modulates endothelial cells senescence.
Li Z, Guo G, Wang H, Si X, Zhou G, Xiong Y, Li S, Dai R, Yang C
European journal of pharmacology 2017 May 5;802:27-35
European journal of pharmacology 2017 May 5;802:27-35
Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.
Qi Y, Li X, Chang C, Xu F, He Q, Zhao Y, Wu L
Scientific reports 2017 May 24;7(1):2323
Scientific reports 2017 May 24;7(1):2323
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Ma Y, Fu HL, Wang Z, Huang H, Ni J, Song J, Xia Y, Jin WL, Cui DX
Oncotarget 2017 May 16;8(20):33329-33342
Oncotarget 2017 May 16;8(20):33329-33342
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, Tao Y, Shi W, Liu J
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.
Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Liu RM, Thannickal VJ, Liu G
American journal of physiology. Lung cellular and molecular physiology 2017 Mar 1;312(3):L415-L424
American journal of physiology. Lung cellular and molecular physiology 2017 Mar 1;312(3):L415-L424
SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.
Yu Z, Sun Y, She X, Wang Z, Chen S, Deng Z, Zhang Y, Liu Q, Liu Q, Zhao C, Li P, Liu C, Feng J, Fu H, Li G, Wu M
Journal of hematology & oncology 2017 Jun 8;10(1):115
Journal of hematology & oncology 2017 Jun 8;10(1):115
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
Lin G, Zhu S, Wu Y, Song C, Wang W, Zhang Y, Chen YL, He Z
Scientific reports 2017 Jun 7;7(1):2929
Scientific reports 2017 Jun 7;7(1):2929
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Liu L, Liu Y, Chen X, Wang M, Zhou Y, Zhou P, Li W, Zhu F
Oncotarget 2017 Jul 4;8(27):43990-44003
Oncotarget 2017 Jul 4;8(27):43990-44003
Long non-coding RNA UCA1 promotes gallbladder cancer progression by epigenetically repressing p21 and E-cadherin expression.
Cai Q, Jin L, Wang S, Zhou D, Wang J, Tang Z, Quan Z
Oncotarget 2017 Jul 18;8(29):47957-47968
Oncotarget 2017 Jul 18;8(29):47957-47968
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Hu YH, Chen Q, Lu YX, Zhang JM, Lin C, Zhang F, Zhang WJ, Li XM, Zhang W, Li XN
Oncotarget 2017 Jul 11;8(28):46191-46203
Oncotarget 2017 Jul 11;8(28):46191-46203
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Zu G, Yao J, Ji A, Ning S, Luo F, Li Z, Feng D, Rui Y, Li Y, Wang G, Tian X
Journal of molecular medicine (Berlin, Germany) 2017 Jan;95(1):83-95
Journal of molecular medicine (Berlin, Germany) 2017 Jan;95(1):83-95
Cigarette smoke extract-induced proliferation of normal human urothelial cells via the MAPK/AP-1 pathway.
Geng H, Zhao L, Liang Z, Zhang Z, Xie D, Bi L, Wang Y, Zhang T, Cheng L, Yu D, Zhong C
Oncology letters 2017 Jan;13(1):469-475
Oncology letters 2017 Jan;13(1):469-475
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence.
Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Antony VB, Thannickal VJ, Liu G
American journal of respiratory cell and molecular biology 2017 Feb;56(2):168-178
American journal of respiratory cell and molecular biology 2017 Feb;56(2):168-178
ISG15 inhibits cancer cell growth and promotes apoptosis.
Zhou MJ, Chen FZ, Chen HC, Wan XX, Zhou X, Fang Q, Zhang DZ
International journal of molecular medicine 2017 Feb;39(2):446-452
International journal of molecular medicine 2017 Feb;39(2):446-452
Tetrandrine antagonizes acute megakaryoblastic leukaemia growth by forcing autophagy-mediated differentiation.
Liu T, Zhang Z, Yu C, Zeng C, Xu X, Wu G, Huang Z, Li W
British journal of pharmacology 2017 Dec;174(23):4308-4328
British journal of pharmacology 2017 Dec;174(23):4308-4328
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, Guo R, Cai Y, Liu Y, Li Y
Molecular medicine reports 2017 Dec;16(6):9137-9142
Molecular medicine reports 2017 Dec;16(6):9137-9142
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Ma Y, Jiang J, Zhang Y, Ding Y, Xu T, Lu B
Molecular medicine reports 2017 Aug;16(2):1445-1450
Molecular medicine reports 2017 Aug;16(2):1445-1450
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Zhou Z, Yin Y, Chang Q, Sun G, Lin J, Dai Y
Cell proliferation 2017 Apr;50(2)
Cell proliferation 2017 Apr;50(2)
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, Fu H
EMBO reports 2017 Apr;18(4):536-548
EMBO reports 2017 Apr;18(4):536-548
Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa.
Ma H, Li L, Dou G, Wang C, Li J, He H, Wu M, Qi H
Oncotarget 2017 Apr 25;8(17):29328-29345
Oncotarget 2017 Apr 25;8(17):29328-29345
Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21, P27 and p38MAPK/MMP-9.
Hao XN, Wang WJ, Chen J, Zhou Q, Qu YX, Liu XY, Xu W
International journal of ophthalmology 2016;9(12):1725-1731
International journal of ophthalmology 2016;9(12):1725-1731
Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells.
Chen ZH, Hu HK, Zhang CR, Lu CY, Bao Y, Cai Z, Zou YX, Hu GH, Jiang L
American journal of translational research 2016;8(10):4106-4119
American journal of translational research 2016;8(10):4106-4119
Berberine enhances the anti‑tumor activity of tamoxifen in drug‑sensitive MCF‑7 and drug‑resistant MCF‑7/TAM cells.
Wen C, Wu L, Fu L, Zhang X, Zhou H
Molecular medicine reports 2016 Sep;14(3):2250-6
Molecular medicine reports 2016 Sep;14(3):2250-6
Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival.
Liao Y, Chu HP, Hu Z, Merkin JJ, Chen J, Liu Z, Degenhardt K, White E, Ryazanov AG
The Journal of biological chemistry 2016 Sep 9;291(37):19545-57
The Journal of biological chemistry 2016 Sep 9;291(37):19545-57
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Wang Y, Zhang XN, Xie WH, Zheng YX, Cao JP, Cao PR, Chen QJ, Li X, Sun CD
Nutrients 2016 Sep 27;8(10)
Nutrients 2016 Sep 27;8(10)
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
Dia VP, Krishnan HB
Scientific reports 2016 Sep 15;6:33532
Scientific reports 2016 Sep 15;6:33532
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Oncology letters 2016 Oct;12(4):2632-2640
Oncology letters 2016 Oct;12(4):2632-2640
Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma.
Zhan L, Cao H, Wang G, Lyu Y, Sun X, An J, Wu Z, Huang Q, Liu B, Xing J
Oncotarget 2016 Oct 4;7(40):65001-65011
Oncotarget 2016 Oct 4;7(40):65001-65011
Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression.
Ye J, Yao Y, Song Q, Li S, Hu Z, Yu Y, Hu C, Da X, Li H, Chen Q, Wang QK
Scientific reports 2016 Oct 4;6:34034
Scientific reports 2016 Oct 4;6:34034
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, Shen L, Luo A, Wang S
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.
Fischer A, Warscheid B, Weber W, Radziwill G
Scientific reports 2016 Nov 30;6:38155
Scientific reports 2016 Nov 30;6:38155
Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress.
Dai Y, Wang L, Tang J, Cao P, Luo Z, Sun J, Kiflu A, Sai B, Zhang M, Wang F, Li G, Xiang J
Oncotarget 2016 May 3;7(18):25478-92
Oncotarget 2016 May 3;7(18):25478-92
The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma: A carcinogenesis, progression, prognosis, and target therapy marker.
Chen S, Sun KX, Liu BL, Zong ZH, Zhao Y
Oncotarget 2016 May 10;7(19):27538-51
Oncotarget 2016 May 10;7(19):27538-51
Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.
Fei Z, Gao Y, Qiu M, Qi X, Dai Y, Wang S, Quan Z, Liu Y, Ou J
Journal of clinical biochemistry and nutrition 2016 Mar;58(2):105-13
Journal of clinical biochemistry and nutrition 2016 Mar;58(2):105-13
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
Xu X, Pang J, Chen Y, Bucala R, Zhang Y, Ren J
Scientific reports 2016 Mar 4;6:22488
Scientific reports 2016 Mar 4;6:22488
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
Feng T, Shao F, Wu Q, Zhang X, Xu D, Qian K, Xie Y, Wang S, Xu N, Wang Y, Qi C
Oncotarget 2016 Mar 29;7(13):16205-16
Oncotarget 2016 Mar 29;7(13):16205-16
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Macrophage migration inhibitory factor in the regulation of myoblast proliferation and differentiation.
Wen F, Zheng J, Yu J, Gao M, Gao S, Zhou Y, Liu J, Yang Z
Bioscience, biotechnology, and biochemistry 2016 Jul;80(7):1313-20
Bioscience, biotechnology, and biochemistry 2016 Jul;80(7):1313-20
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, Xie C
Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats.
Wang WJ, Cai GY, Ning YC, Cui J, Hong Q, Bai XY, Xu XM, Bu R, Sun XF, Chen XM
Scientific reports 2016 Jul 26;6:30292
Scientific reports 2016 Jul 26;6:30292
A novelly synthesized phenanthroline derivative is a promising DNA-damaging anticancer agent inhibiting G1/S checkpoint transition and inducing cell apoptosis in cancer cells.
Zhen N, Yang Q, Wu Q, Zhu X, Wang Y, Sun F, Mei W, Yu Y
Cancer chemotherapy and pharmacology 2016 Jan;77(1):169-80
Cancer chemotherapy and pharmacology 2016 Jan;77(1):169-80
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Deng S, Tang S, Dai C, Zhou Y, Yang X, Li D, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
MiR-512-5p induces apoptosis and inhibits glycolysis by targeting p21 in non-small cell lung cancer cells.
Chu K, Gao G, Yang X, Ren S, Li Y, Wu H, Huang Y, Zhou C
International journal of oncology 2016 Feb;48(2):577-86
International journal of oncology 2016 Feb;48(2):577-86
miRNA-149* promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia.
Fan SJ, Li HB, Cui G, Kong XL, Sun LL, Zhao YQ, Li YH, Zhou J
Leukemia research 2016 Feb;41:62-70
Leukemia research 2016 Feb;41:62-70
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Chen P, Yu N, Zhang Z, Zhang P, Yang Y, Wu N, Xu L, Zhang J, Ge J, Yu K, Zhuang J
Oncotarget 2016 Feb 2;7(5):6105-20
Oncotarget 2016 Feb 2;7(5):6105-20
Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21(Waf1/Cip1) and p27(Kip1).
Zhou Y, Wang K, Zhen S, Wang R, Luo W
Taiwanese journal of obstetrics & gynecology 2016 Dec;55(6):847-851
Taiwanese journal of obstetrics & gynecology 2016 Dec;55(6):847-851
Simvastatin exerts anti-hepatitis B virus activity by inhibiting expression of minichromosome maintenance protein 7 in HepG2.2.15 cells.
Li W, Cao F, Li J, Wang Z, Ren Y, Liang Z, Liu P
Molecular medicine reports 2016 Dec;14(6):5334-5342
Molecular medicine reports 2016 Dec;14(6):5334-5342
A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.
Xia L, Wang XR, Wang XL, Liu SH, Ding XW, Chen GQ, Lu Y
The Journal of biological chemistry 2016 Dec 9;291(50):26138-26150
The Journal of biological chemistry 2016 Dec 9;291(50):26138-26150
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, Li Y, Bao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
RNA interference of Biot2 induces G1 phase arrest and apoptosis in mouse colorectal cancer cell line.
Zhou C, Zhang P, Xu GC, Wu DM, Liu RY, Zeng Q, Wang CT
Oncology research 2015;22(2):93-103
Oncology research 2015;22(2):93-103
Study on the Dynamic Biological Characteristics of Sca-1(+) Hematopoietic Stem and Progenitor Cell Senescence.
Geng S, Mu XY, Chen XB, Hou JY, Jia DY, Xu CY, Wang YP
Stem cells international 2015;2015:954120
Stem cells international 2015;2015:954120
Induction of Apoptosis in Human Leukemic Cell Lines by Diallyl Disulfide via Modulation of EGFR/ERK/PKM2 Signaling Pathways.
Luo N, Zhao LC, Shi QQ, Feng ZQ, Chen DL, Li J
Asian Pacific journal of cancer prevention : APJCP 2015;16(8):3509-15
Asian Pacific journal of cancer prevention : APJCP 2015;16(8):3509-15
Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549.
Wu DM, Zhang P, Xu GC, Tong AP, Zhou C, Lang JY, Wang CT
Asian Pacific journal of cancer prevention : APJCP 2015;16(4):1507-13
Asian Pacific journal of cancer prevention : APJCP 2015;16(4):1507-13
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
Mo C, Zhao R, Vallejo J, Igwe O, Bonewald L, Wetmore L, Brotto M
Cell cycle (Georgetown, Tex.) 2015;14(10):1507-16
Cell cycle (Georgetown, Tex.) 2015;14(10):1507-16
Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability.
Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, Sui Y, Zhao T, Wang F, Jin J, Cai Y
PloS one 2015;10(9):e0137411
PloS one 2015;10(9):e0137411
Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.
Ying Q, Ansong E, Diamond AM, Lu Z, Yang W, Bie X
PloS one 2015;10(5):e0126285
PloS one 2015;10(5):e0126285
MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3.
Fan Z, Cui H, Xu X, Lin Z, Zhang X, Kang L, Han B, Meng J, Yan Z, Yan X, Jiao S
Oncotarget 2015 Sep 22;6(28):25266-80
Oncotarget 2015 Sep 22;6(28):25266-80
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X, Ye L
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Wang X, Han L, Zhang J, Xia Q
Digestive diseases and sciences 2015 Oct;60(10):3011-8
Digestive diseases and sciences 2015 Oct;60(10):3011-8
FXR induces SOCS3 and suppresses hepatocellular carcinoma.
Guo F, Xu Z, Zhang Y, Jiang P, Huang G, Chen S, Lyu X, Zheng P, Zhao X, Zeng Y, Wang S, He F
Oncotarget 2015 Oct 27;6(33):34606-16
Oncotarget 2015 Oct 27;6(33):34606-16
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Hua Y, Robinson TJ, Cao Y, Shi GP, Ren J, Nair S
Aging cell 2015 Jun;14(3):345-51
Aging cell 2015 Jun;14(3):345-51
Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.
Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang XC, Duan Y, Han J
The Journal of biological chemistry 2015 Jun 5;290(23):14418-29
The Journal of biological chemistry 2015 Jun 5;290(23):14418-29
MKL1 inhibits cell cycle progression through p21 in podocytes.
Yang S, Liu L, Xu P, Yang Z
BMC molecular biology 2015 Feb 12;16(1):1
BMC molecular biology 2015 Feb 12;16(1):1
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
Sun S, Cheng B, Sun PG, Wu XH, Wu QQ, He P
Experimental biology and medicine (Maywood, N.J.) 2015 Dec;240(12):1606-13
Experimental biology and medicine (Maywood, N.J.) 2015 Dec;240(12):1606-13
Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy.
Zhu L, Dong C, Sun C, Ma R, Yang D, Zhu H, Xu J
Biochemical and biophysical research communications 2015 Aug 21;464(2):526-33
Biochemical and biophysical research communications 2015 Aug 21;464(2):526-33
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects.
Zalc A, Rattenbach R, Auradé F, Cadot B, Relaix F
Developmental cell 2015 Apr 6;33(1):56-66
Developmental cell 2015 Apr 6;33(1):56-66
Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells.
Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X, Li W
Oncotarget 2015 Apr 10;6(10):7992-8006
Oncotarget 2015 Apr 10;6(10):7992-8006
Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.
Storbeck M, Hupperich K, Gaspar JA, Meganathan K, Martínez Carrera L, Wirth R, Sachinidis A, Wirth B
PloS one 2014;9(2):e89020
PloS one 2014;9(2):e89020
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Ning Z, Wang A, Liang J, Xie Y, Liu J, Feng L, Yan Q, Wang Z
International journal of oncology 2014 Oct;45(4):1594-608
International journal of oncology 2014 Oct;45(4):1594-608
The involvement of CXCR7 in modulating the progression of papillary thyroid carcinoma.
Liu Z, Yang L, Teng X, Zhang H, Guan H
The Journal of surgical research 2014 Oct;191(2):379-88
The Journal of surgical research 2014 Oct;191(2):379-88
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Yang CF, Peng LX, Huang TJ, Yang GD, Chu QQ, Liang YY, Cao X, Xie P, Zheng LS, Huang HB, Cai MD, Huang JL, Liu RY, Zhu ZY, Qian CN, Huang BJ
Cancer letters 2014 Mar 28;344(2):260-71
Cancer letters 2014 Mar 28;344(2):260-71
Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.
Sun Q, Wang R, Wang Y, Luo J, Wang P, Cheng B
Oncology reports 2014 Feb;31(2):933-9
Oncology reports 2014 Feb;31(2):933-9
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Wu Q, He J, Mei W, Zhang Z, Wu X, Sun F
Metallomics : integrated biometal science 2014 Dec;6(12):2204-12
Metallomics : integrated biometal science 2014 Dec;6(12):2204-12
Association of p53/p21 expression and cigarette smoking with tumor progression and poor prognosis in non-small cell lung cancer patients.
Xie D, Lan L, Huang K, Chen L, Xu C, Wang R, Shi Y, Wu X, Wang L, Liu Y, Lu B
Oncology reports 2014 Dec;32(6):2517-26
Oncology reports 2014 Dec;32(6):2517-26
Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma.
Lv Z, Wu X, Cao W, Shen Z, Wang L, Xie F, Zhang J, Ji T, Yan M, Chen W
Journal of experimental & clinical cancer research : CR 2014 Dec 18;33(1):100
Journal of experimental & clinical cancer research : CR 2014 Dec 18;33(1):100
miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.
Jung HM, Phillips BL, Chan EK
Molecular cancer 2014 Apr 8;13:80
Molecular cancer 2014 Apr 8;13:80
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D
Cell reports 2013 May 30;3(5):1663-77
Cell reports 2013 May 30;3(5):1663-77
Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA.
Cun B, Song X, Jia R, Wang H, Zhao X, Liu B, Ge S, Fan X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Jun;34(3):1801-6
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Jun;34(3):1801-6
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Zhang J, Sun Q, Zhang Z, Ge S, Han ZG, Chen WT
Oncogene 2013 Jan 3;32(1):61-9
Oncogene 2013 Jan 3;32(1):61-9
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Xu X, Hueckstaedt LK, Ren J
Journal of hepatology 2013 Aug;59(2):308-17
Journal of hepatology 2013 Aug;59(2):308-17
Enhanced therapeutic efficacy of vitamin K2 by silencing BCL-2 expression in SMMC-7721 hepatocellular carcinoma cells.
Yao Y, Li L, Zhang H, Jia R, Liu B, Zhao X, Zhang L, Qian G, Fan X, Ge S
Oncology letters 2012 Jul;4(1):163-167
Oncology letters 2012 Jul;4(1):163-167
Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis.
Kamar N, Izopet J, Cintas P, Garrouste C, Uro-Coste E, Cointault O, Rostaing L
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 May;10(5):1321-4
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010 May;10(5):1321-4
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10355-1-AP(P21 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10355-1-AP(P21 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10355-1-AP(P21 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
