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LearnGTX100444
antibody from GeneTex
Targeting: CDKN1A
CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- GTX100444 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX100444, RRID:AB_2037582
- Product name
- p21 Cip1 antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Rat
- Host
- Rabbit
Submitted references Rhodiola crenulata Attenuates γ-Ray Induced Cellular Injury via Modulation of Oxidative Stress in Human Skin Cells.
Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.
Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells.
Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells.
Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells.
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells.
Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma.
Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells.
Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo.
Blackberry, raspberry and black raspberry polyphenol extracts attenuate angiotensin II-induced senescence in vascular smooth muscle cells.
Effects of Camphorquinone on Cytotoxicity, Cell Cycle Regulation and Prostaglandin E2 Production of Dental Pulp Cells: Role of ROS, ATM/Chk2, MEK/ERK and Hemeoxygenase-1.
Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.
The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway.
Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo.
Lin KT, Chang TC, Lai FY, Lin CS, Chao HL, Lee SY
The American journal of Chinese medicine 2018;46(1):175-190
The American journal of Chinese medicine 2018;46(1):175-190
Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.
Briest F, Grass I, Sedding D, Möbs M, Christen F, Benecke J, Fuchs K, Mende S, Kaemmerer D, Sänger J, Kunze A, Geisler C, Freitag H, Lewens F, Worpenberg L, Iwaszkiewicz S, Siegmund B, Walther W, Hummel M, Grabowski P
Neuroendocrinology 2018;107(1):1-23
Neuroendocrinology 2018;107(1):1-23
Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells.
Park SH, Kim JH, Ko E, Kim JY, Park MJ, Kim MJ, Seo H, Li S, Lee JY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May 29;:fj201800011R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May 29;:fj201800011R
Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells.
Liu YH, Weng YP, Tsai HY, Chen CJ, Lee DY, Hsieh CL, Wu YC, Lin JY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:184-192
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:184-192
Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells.
Salazar G, Huang J, Feresin RG, Zhao Y, Griendling KK
Free radical biology & medicine 2017 Jul;108:225-235
Free radical biology & medicine 2017 Jul;108:225-235
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells.
Liu YH, Weng YP, Lin HY, Tang SW, Chen CJ, Liang CJ, Ku CY, Lin JY
Scientific reports 2017 Jan 30;7:41437
Scientific reports 2017 Jan 30;7:41437
Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma.
Chiu YS, Hsing CH, Li CF, Lee CY, Hsu YH, Chang MS
Scientific reports 2017 Dec 14;7(1):17609
Scientific reports 2017 Dec 14;7(1):17609
Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells.
So EC, Chen YC, Wang SC, Wu CC, Huang MC, Lai MS, Pan BS, Kang FC, Huang BM
OncoTargets and therapy 2016;9:2519-33
OncoTargets and therapy 2016;9:2519-33
Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo.
Chen CC, Liang CJ, Leu YL, Chen YL, Wang SH
PloS one 2016;11(12):e0168092
PloS one 2016;11(12):e0168092
Blackberry, raspberry and black raspberry polyphenol extracts attenuate angiotensin II-induced senescence in vascular smooth muscle cells.
Feresin RG, Huang J, Klarich DS, Zhao Y, Pourafshar S, Arjmandi BH, Salazar G
Food & function 2016 Oct 12;7(10):4175-4187
Food & function 2016 Oct 12;7(10):4175-4187
Effects of Camphorquinone on Cytotoxicity, Cell Cycle Regulation and Prostaglandin E2 Production of Dental Pulp Cells: Role of ROS, ATM/Chk2, MEK/ERK and Hemeoxygenase-1.
Chang MC, Lin LD, Wu MT, Chan CP, Chang HH, Lee MS, Sun TY, Jeng PY, Yeung SY, Lin HJ, Jeng JH
PloS one 2015;10(12):e0143663
PloS one 2015;10(12):e0143663
Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.
Rodríguez A, Torres L, Juárez U, Sosa D, Azpeitia E, García-de Teresa B, Cortés E, Ortíz R, Salazar AM, Ostrosky-Wegman P, Mendoza L, Frías S
Theoretical biology & medical modelling 2015 Sep 18;12:19
Theoretical biology & medical modelling 2015 Sep 18;12:19
The synthetic flavonoid WYC02-9 inhibits colorectal cancer cell growth through ROS-mediated activation of MAPK14 pathway.
Chen YJ, Chen HP, Cheng YJ, Lin YH, Liu KW, Chen YJ, Hou MF, Wu YC, Lee YC, Yuan SS
Life sciences 2013 Jun 13;92(22):1081-92
Life sciences 2013 Jun 13;92(22):1081-92
Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo.
Wang SH, Liang CJ, Weng YW, Chen YH, Hsu HY, Chien HF, Tsai JS, Tseng YC, Li CY, Chen YL
Journal of cellular physiology 2012 Aug;227(8):3063-71
Journal of cellular physiology 2012 Aug;227(8):3063-71
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Sample (30 ?g of whole cell lysate) A: HCT116 B: HCT116 treated with 30 ?M cisplatin for 24 hr 12% SDS PAGE GTX100444 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- p21 Cip1 antibody detects p21 Cip1 protein at nucleus by immunofluorescent analysis. Samples: HCT116 cells mock (left) and treated with 30 £gM Cisplatin for 24 hrs (right) were fixed in 4% paraformaldehyde at RT for 15 min.Green: p21 Cip1 protein stained by p21 Cip1 antibody (GTX100444) diluted at 1:1000.Red: Histone H3S10ph (phospho Ser10), a nucleus marker, stained by Histone H3S10ph (phospho Ser10) antibody [GT921] (GTX630185) diluted at 1:500.Blue: Hoechst 33342 staining.
