MA5-12764
antibody from Invitrogen Antibodies
Targeting: CDKN1A
CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1
Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Other assay [4]
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Validation data
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- Product number
- MA5-12764 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-p21 Monoclonal Antibody (DCS-60.2)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA5-12764 targets p21WAF1 in IF, IHC (P), and IP applications and shows reactivity with Human samples. The MA5-12764 immunogen is full length human recombinant p21 protein.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- DCS-60.2
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG.
Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation.
Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma.
Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature.
Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.
Nutlin-3a is a potential therapeutic for ewing sarcoma.
Sporadic colorectal carcinomas with low-level microsatellite instability: a distinct subgroup with specific clinicopathological and molecular features.
Papillary carcinoma with diffuse papillomatosis of gallbladder and cystic duct.
Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study.
Endometriosis-associated skeletal muscle regeneration: a hitherto undescribed entity and a potential diagnostic pitfall.
Role of efflux pump activity in lapatinib/caelyx combination in breast cancer cell lines.
Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.
A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary.
SKI knockdown inhibits human melanoma tumor growth in vivo.
Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis.
Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features.
Expression of senescence-related genes in human corneal endothelial cells.
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities.
Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy.
Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues.
Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?
Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.
Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases.
Dissemination of a Sjögren's syndrome-associated extranodal marginal-zone B cell lymphoma: circulating lymphoma cells and invariant mutation pattern of nodal Ig heavy- and light-chain variable-region gene rearrangements.
TP53 overexpression in recurrent endometrial carcinoma.
Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen.
Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers.
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
Gap junctional intercellular communication and cellular response to heat stress.
Human tumor suppressor ARF impedes S-phase progression independent of p53.
Tillhon M, Cazzalini O, Nardo T, Necchi D, Sommatis S, Stivala LA, Scovassi AI, Prosperi E
DNA repair 2012 Oct 1;11(10):844-52
DNA repair 2012 Oct 1;11(10):844-52
Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation.
Suzuki M, Yamauchi M, Oka Y, Suzuki K, Yamashita S
International journal of radiation oncology, biology, physics 2012 Jun 1;83(2):e241-50
International journal of radiation oncology, biology, physics 2012 Jun 1;83(2):e241-50
Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma.
Perisanidis C, Perisanidis B, Wrba F, Brandstetter A, El Gazzar S, Papadogeorgakis N, Seemann R, Ewers R, Kyzas PA, Filipits M
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2012 Jan;41(1):40-6
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2012 Jan;41(1):40-6
Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature.
Schaefer IM, Cameron S, Middel P, Homayounfar K, Schwörer H, Vieth M, Veits L
BMC cancer 2012 Dec 4;12:570
BMC cancer 2012 Dec 4;12:570
Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.
Greenspan EJ, Madigan JP, Boardman LA, Rosenberg DW
Cancer prevention research (Philadelphia, Pa.) 2011 Jan;4(1):161-71
Cancer prevention research (Philadelphia, Pa.) 2011 Jan;4(1):161-71
Nutlin-3a is a potential therapeutic for ewing sarcoma.
Pishas KI, Al-Ejeh F, Zinonos I, Kumar R, Evdokiou A, Brown MP, Callen DF, Neilsen PM
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Feb 1;17(3):494-504
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Feb 1;17(3):494-504
Sporadic colorectal carcinomas with low-level microsatellite instability: a distinct subgroup with specific clinicopathological and molecular features.
Azzoni C, Bottarelli L, Cecchini S, Silini EM, Bordi C, Sarli L
International journal of colorectal disease 2011 Apr;26(4):445-53
International journal of colorectal disease 2011 Apr;26(4):445-53
Papillary carcinoma with diffuse papillomatosis of gallbladder and cystic duct.
Kosemehmetoglu K, Akpinar E, Sokmensuer C, Hamaloglu E
Annals of diagnostic pathology 2011 Apr;15(2):140-4
Annals of diagnostic pathology 2011 Apr;15(2):140-4
Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study.
Safadi RA, Al Jaber SZ, Hammad HM, Hamasha AA
Archives of oral biology 2010 Jun;55(6):454-61
Archives of oral biology 2010 Jun;55(6):454-61
Endometriosis-associated skeletal muscle regeneration: a hitherto undescribed entity and a potential diagnostic pitfall.
Colella R, Mameli MG, Bellezza G, Sordo RD, Cavaliere A, Sidoni A
The American journal of surgical pathology 2010 Jan;34(1):10-7
The American journal of surgical pathology 2010 Jan;34(1):10-7
Role of efflux pump activity in lapatinib/caelyx combination in breast cancer cell lines.
Vannini I, Zoli W, Fabbri F, Ulivi P, Tesei A, Carloni S, Brigliadori G, Amadori D
Anti-cancer drugs 2009 Nov;20(10):918-25
Anti-cancer drugs 2009 Nov;20(10):918-25
Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.
Savio M, Coppa T, Cazzalini O, Perucca P, Necchi D, Nardo T, Stivala LA, Prosperi E
DNA repair 2009 Jul 4;8(7):778-85
DNA repair 2009 Jul 4;8(7):778-85
A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary.
Köbel M, Kalloger SE, Carrick J, Huntsman D, Asad H, Oliva E, Ewanowich CA, Soslow RA, Gilks CB
The American journal of surgical pathology 2009 Jan;33(1):14-21
The American journal of surgical pathology 2009 Jan;33(1):14-21
SKI knockdown inhibits human melanoma tumor growth in vivo.
Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE
Pigment cell & melanoma research 2009 Dec;22(6):761-72
Pigment cell & melanoma research 2009 Dec;22(6):761-72
Epithelial expression of p53, mdm-2 and p21 in normal lip and actinic cheilitis.
Martínez A, Brethauer U, Borlando J, Spencer ML, Rojas IG
Oral oncology 2008 Sep;44(9):878-83
Oral oncology 2008 Sep;44(9):878-83
Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features.
Leopoldo S, Lorena B, Cinzia A, Gabriella DC, Angela Luciana B, Renato C, Antonio M, Carlo S, Cristina P, Stefano C, Maurizio T, Luigi R, Cesare B
Annals of surgical oncology 2008 May;15(5):1429-39
Annals of surgical oncology 2008 May;15(5):1429-39
Expression of senescence-related genes in human corneal endothelial cells.
Song Z, Wang Y, Xie L, Zang X, Yin H
Molecular vision 2008 Jan 29;14:161-70
Molecular vision 2008 Jan 29;14:161-70
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities.
Press JZ, De Luca A, Boyd N, Young S, Troussard A, Ridge Y, Kaurah P, Kalloger SE, Blood KA, Smith M, Spellman PT, Wang Y, Miller DM, Horsman D, Faham M, Gilks CB, Gray J, Huntsman DG
BMC cancer 2008 Jan 22;8:17
BMC cancer 2008 Jan 22;8:17
Biological predictive factors in rectal cancer treated with preoperative radiotherapy or radiochemotherapy.
Negri FV, Campanini N, Camisa R, Pucci F, Bui S, Ceccon G, Martinelli R, Fumagalli M, Losardo PL, Crafa P, Bordi C, Cascinu S, Ardizzoni A
British journal of cancer 2008 Jan 15;98(1):143-7
British journal of cancer 2008 Jan 15;98(1):143-7
Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues.
Eigeliene N, Härkönen P, Erkkola R
Cell cycle (Georgetown, Tex.) 2008 Jan 1;7(1):71-80
Cell cycle (Georgetown, Tex.) 2008 Jan 1;7(1):71-80
Expressions of p53, VEGF C, p21: could they be used in preoperative evaluation of lymph node metastasis of esophageal squamous cell carcinoma?
Han U, Can OI, Han S, Kayhan B, Onal BU
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2007;20(5):379-85
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2007;20(5):379-85
Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.
Young TW, Rosen DG, Mei FC, Li N, Liu J, Wang XF, Cheng X
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jul 1;13(13):3848-54
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Jul 1;13(13):3848-54
Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases.
Esposito NN, Mohan D, Brufsky A, Lin Y, Kapali M, Dabbs DJ
Archives of pathology & laboratory medicine 2006 Oct;130(10):1516-21
Archives of pathology & laboratory medicine 2006 Oct;130(10):1516-21
Dissemination of a Sjögren's syndrome-associated extranodal marginal-zone B cell lymphoma: circulating lymphoma cells and invariant mutation pattern of nodal Ig heavy- and light-chain variable-region gene rearrangements.
Hansen A, Reiter K, Pruss A, Loddenkemper C, Kaufmann O, Jacobi AM, Scholze J, Lipsky PE, Dörner T
Arthritis and rheumatism 2006 Jan;54(1):127-37
Arthritis and rheumatism 2006 Jan;54(1):127-37
TP53 overexpression in recurrent endometrial carcinoma.
Pijnenborg JM, van de Broek L, Dam de Veen GC, Roemen GM, de Haan J, van Engeland M, Voncken JW, Groothuis PG
Gynecologic oncology 2006 Feb;100(2):397-404
Gynecologic oncology 2006 Feb;100(2):397-404
Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen.
Perucca P, Cazzalini O, Mortusewicz O, Necchi D, Savio M, Nardo T, Stivala LA, Leonhardt H, Cardoso MC, Prosperi E
Journal of cell science 2006 Apr 15;119(Pt 8):1517-27
Journal of cell science 2006 Apr 15;119(Pt 8):1517-27
Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers.
Au NH, Cheang M, Huntsman DG, Yorida E, Coldman A, Elliott WM, Bebb G, Flint J, English J, Gilks CB, Grimes HL
The Journal of pathology 2004 Sep;204(1):101-9
The Journal of pathology 2004 Sep;204(1):101-9
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
Jayasurya R, Francis G, Kannan S, Lekshminarayanan K, Nalinakumari KR, Abraham T, Abraham EK, Nair MK
International journal of cancer 2004 May 1;109(5):710-6
International journal of cancer 2004 May 1;109(5):710-6
Gap junctional intercellular communication and cellular response to heat stress.
Hamada N, Kodama S, Suzuki K, Watanabe M
Carcinogenesis 2003 Nov;24(11):1723-8
Carcinogenesis 2003 Nov;24(11):1723-8
Human tumor suppressor ARF impedes S-phase progression independent of p53.
Yarbrough WG, Bessho M, Zanation A, Bisi JE, Xiong Y
Cancer research 2002 Feb 15;62(4):1171-7
Cancer research 2002 Feb 15;62(4):1171-7
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human colon carcinoma stained with p21waf1 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of p21/Cip1 (green) showing staining in the nucleus of Hela cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a p21/Cip1 monoclonal antibody (Product # MA5-12764) in 3% BSA-PBS at a dilution of 1:20 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. Actin was stained using Alexa Fluor 554 (red) and nuclei were stained with Hoechst or DAPI (blue). Images were taken at a magnification of 60x.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of p21/Cip1 (green) showing staining in the nucleus of MCF-7 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a p21/Cip1 monoclonal antibody (Product # MA5-12764) in 3% BSA-PBS at a dilution of 1:20 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. Actin was stained using Alexa Fluor 554 (red) and nuclei were stained with Hoechst or DAPI (blue). Images were taken at a magnification of 60x.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunoprecipitation of p21WAF1 using p21WAF1 Monoclonal Antibody (MA5-12764) on Native Human LS174T Cells.