10048-2-Ig

antibody from Proteintech Group

Targeting: RB1 OSRC, PPP1R130, RB

Provider product page for 10048-2-Ig

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [79]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 10048-2-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10048-2-Ig, RRID:AB_2177320
Product name: RB1 antibody
Antibody type: Polyclonal
Description: KD/KO validated RB1 antibody (Cat. #10048-2-Ig) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RB1 protein structure - 10048-2-Ig shown in red.

Submitted references Tumor Prostate-Specific Antigen Density Can Predict Tumor Aggressiveness and Heterogeneity in Prostate Cancer.

Yang T, Wang X, Deng Y, Liu H, Chen Y, Zhao J, Huang Y, Liu S, Cao M, Zhang Q, Wang X, Xu H, Wu D, Zhuo H
The Prostate 2026 May;86(7):821-830

PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment.

Chen H, Hu X, Feng L, Cheng X, Zhu L, Xu F, Zhu T, Gao Y, Wang J, Jin H, Jiang Z
Oncogene 2026 May;45(19):1756-1770

Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma.

Hattori T, Fujii M, Ueda T, Ishikawa A, Mine Y, Xu B, Suehiro T, Hattori M, Tahara H, Sato Y, Chikuie N, Taruya T, Hamamoto T, Ishino T, Takeno S
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2026 Mar;174(3):784-791

CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma.

Cao Y, Xu C, Liu Y, Shi B, Li X, Li J, Zhang B, Zhang Z, Dai S, Sun Q, Gu J
iScience 2026 Mar 20;29(3):114840

Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer.

Liu Z, Qin Z, Li H, Zhu L, He L, Chen N, Zhu D, Liu Q, Dai L, Peng X
Signal transduction and targeted therapy 2026 Mar 18;11(1)

circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis.

Wu HY, Zhou CM, Gao Y, Wen YH, Hu YT, Zhao HL, Dong WY, Liu XY, Zhai L, Li Y, Zhang MZ, Zhu JN, Li H, Xu JD, Ma N, Liu YP, Zheng XL, Fang XH, Shan ZX
Acta pharmacologica Sinica 2026 Jan;47(1):86-102

Mechanisms underlying the therapeutic effects of Amygdalin in treating Cervical Cancer based on multi-omics analysis.

Jiang Q, Xu R, Cheng J, Shi Y, Zhu T, Yu M, Cui X, Lin C
Journal of pharmaceutical and biomedical analysis 2026 Jan 15;268:117232

LncRNA H19-Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160.

Zhang Y, Li W, Cao X, Mao J, Zhou X, Liu L, Yao R
Cell proliferation 2026 Feb;59(2):e70089

Case Report: A novel germline donor splicing site mutation of RB1 gene in a Chinese Tibetan pedigree with familial retinoblastoma.

He GQ, Zheng YC, Tan LJ, Shen CQ, Gao J, Xiong F, Guo X
Frontiers in oncology 2025;15:1525035

Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.

Zhan Y, Deng Z, Yang R, Chen S, Zhang J, Zhang Y, Fu H, Huang Q, Gu Y, Zeng Z, Chen J, Zhang J, Wu J, Xie J
MedComm 2025 Sep;6(9):e70345

FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA.

He Q, Li H, Cong Y, Chen K, Cheng L, Lv F, Zhang P, Ju Y, Yu Z, Chen J, Wang C, Song Y, Li X, Chen L, Xing Y
Neoplasia (New York, N.Y.) 2025 Nov;69:101227

ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC.

Qin W, Shao L, Li Q, Zhang D, Jia X, Dong C
Molecular cancer 2025 Nov 20;24(1):295

Targeting DUSP3 promotes cell senescence by activating the notch1 pathway to treat hepatocellular carcinoma.

Zhang WJ, Peng JL, Dai DF, Huang C, Chen XP
Tissue & cell 2025 Jun;94:102781

Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAF(V600E)-induced growth arrest in melanocytes.

McGrail K, Granado-Martínez P, Orsenigo R, Caratù G, Nieto P, Heyn H, Ferrer B, Hernández-Losa J, Muñoz-Couselo E, García-Patos V, Recio JA
Oncogene 2025 Jun;44(21):1592-1608

A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.

Zhang M, Liu R, Jiang W, Li H, Zhang S, Cheng W, Ye X, He J, Liu Y, Jing A, Song Y, Wang D, Liu X, Zhang B, Wang X, Ji J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131

Discovery of potent and selective CDK2 inhibitors with high safety and favorable bioavailability for the treatment of cancer.

Chen W, Zhuang X, Chen Y, Shen L, Yang H, Wang M, Pan G, Tan J, Pan X, Feng S, Yuan K, Zhang XY, Yang P
European journal of medicinal chemistry 2025 Jun 5;290:117503

SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.

Dong L, Yang Z, Liu J, Wu R, Liao Y, Kuang L
Cellular signalling 2025 Aug;132:111840

Oncoproteins E6 and E7 upregulate topoisomerase I to activate the cGAS-PD-L1 pathway in cervical cancer development.

Luo Y, Niu M, Liu Y, Zhang M, Deng Y, Mu D, Xu J, Hong S
Frontiers in pharmacology 2024;15:1450875

Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo.

Li B, Zhang J, Yu Y, Li Y, Chen Y, Zhao X, Li A, Zhao L, Li M, Wang Z, Lu X, Wu W, Zhang Y, Dong Z, Liu K, Jiang Y
Frontiers of medicine 2024 Oct;18(5):896-910

Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.

Chen C, Wang X, Fang W, Liang J, Cai J, Yang D, Luo X, Gao C, Yi X, Liu Y, Zhou X
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056

Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.

Ren D, Li W, Zeng R, Liu X, Liang H, Xiong W, Yang C, Jin X
Cell death and differentiation 2024 May;31(5):592-604

Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood.

Huo Y, Wang W, Zhang J, Xu D, Bai F, Gui Y
Journal of endocrinological investigation 2024 Mar;47(3):603-617

The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1.

Li N, Zhang E, Li Z, Lv S, Zhao X, Ke Q, Zou Q, Li W, Wang Y, Guo H, Song T, Sun L
The Journal of biological chemistry 2024 Mar;300(3):105707

Synergistic Efficacy of CDK4/6 Inhibitor Abemaciclib and HDAC Inhibitor Panobinostat in Pancreatic Cancer Cells.

Bhutkar S, Yadav A, Patel H, Barot S, Patel K, Dukhande VV
Cancers 2024 Jul 30;16(15)

RNA-binding protein THUMPD2 inhibits proliferation and promotes metastasis in epithelial ovarian cancer.

Hua M, Chen Y, Jia M, Lv W, Xu Y, Zhang Y
Heliyon 2024 Jul 15;10(13):e33201

The anti-tumor efficacy of a recombinant oncolytic herpes simplex virus mediated CRISPR/Cas9 delivery targeting in HPV16-positive cervical cancer.

Hu Z, Liu W, Liu J, Zhou H, Sun C, ChaoTian, Guo X, Zhu C, Shao M, Wang S, Wei L, Liu M, Li S, Wang J, Xu H, Zhu W, Li X, Li J
Antiviral research 2024 Dec;232:106035

CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.

Li W, Guo F, Zeng R, Liang H, Wang Y, Xiong W, Wu H, Yang C, Jin X
Cancer research 2024 Aug 15;84(16):2588-2606

PABPN1 promotes clear cell renal cell carcinoma progression by suppressing the alternative polyadenylation of SGPL1 and CREG1.

Xiong M, Liu C, Li W, Jiang H, Long W, Zhou M, Yang C, Kazobinka G, Sun Y, Zhao J, Hou T
Carcinogenesis 2023 Oct 20;44(7):576-586

N-Acetyl-L-Cysteine Reduces Cervical Carcinogenesis by Promoting Apoptosis.

Guo W, Jing W
Drugs in R&D 2023 Jun;23(2):165-174

CDK4/6 inhibition confers protection of normal gut epithelia against gemcitabine and the active metabolite of irinotecan.

Blume J, Claus L, Isermann T, Dickmanns A, Conradi LC, Schulz-Heddergott R, Dobbelstein M
Cell cycle (Georgetown, Tex.) 2023 Jul;22(13):1563-1582

Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies.

Mei H, Wu H, Yang J, Zhou B, Wang A, Hu C, Qi S, Jiang Z, Zou F, Wang B, Liu F, Chen Y, Wang W, Liu J, Liu Q
Signal transduction and targeted therapy 2023 Jan 16;8(1):18

Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.

Gong Y, Zou S, Deng D, Wang L, Hu H, Qiu Z, Wei T, Yang P, Zhou J, Zhang Y, Zhu W, Xie X, Liao Z, Yang J, Zhang S, Liu A, Jiang Y, Zou Z, Bai X
Developmental cell 2023 Feb 6;58(3):192-210.e11

Oxoglutarate dehydrogenase-like inhibits the progression of hepatocellular carcinoma by inducing DNA damage through non-canonical function.

Jiang X, Peng J, Xie Y, Xu Y, Liu Q, Cheng C, Yan P, Xu S, Wang Y, Zhang L, Li H, Li Y, Li B, Han J, Yu D
Cell death and differentiation 2023 Aug;30(8):1931-1942

Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.

Wang X, Luo X, Gan X, Chen C, Yang Z, Wen J, Fang W, Huang H, Gao C, Zhou X, Feng X, Liu Y
Frontiers in pharmacology 2022;13:920554

Co-Delivery of p53 Restored and E7 Targeted Nucleic Acids by Poly (Beta-Amino Ester) Complex Nanoparticles for the Treatment of HPV Related Cervical Lesions.

Xiong J, Li G, Mei X, Ding J, Shen H, Zhu D, Wang H
Frontiers in pharmacology 2022;13:826771

RB1 Is an Immune-Related Prognostic Biomarker for Ovarian Cancer.

Xie B, Tan G, Ren J, Lu W, Pervaz S, Ren X, Otoo AA, Tang J, Li F, Wang Y, Wang M
Frontiers in oncology 2022;12:830908

Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.

Zhang C, Wang X, Zhang C
iScience 2022 Sep 16;25(9):104991

The application of CRISPR/Cas9 system in cervical carcinogenesis.

Gao C, Wu P, Yu L, Liu L, Liu H, Tan X, Wang L, Huang X, Wang H
Cancer gene therapy 2022 May;29(5):466-474

Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility.

Gallicano GI, Casey JL, Fu J, Mahapatra S
Gene therapy 2022 May;29(5):304-311

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.

Yuan K, Li Z, Kuang W, Wang X, Ji M, Chen W, Ding J, Li J, Min W, Sun C, Ye X, Lu M, Wang L, Ge H, Jiang Y, Hao H, Xiao Y, Yang P
Nature communications 2022 May 25;13(1):2903

USP53 activated by H3K27 acetylation regulates cell viability, apoptosis and metabolism in esophageal carcinoma via the AMPK signaling pathway.

Cheng W, Tang Y, Tong X, Zhou Q, Xie J, Wang J, Han Y, Ta N, Ye Z
Carcinogenesis 2022 May 19;43(4):349-359

The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.

Wang F, Luo Y, Zhang L, Younis M, Yuan L
Cancer gene therapy 2022 Mar;29(3-4):292-303

Bioinformatics analysis combined with experiments to verify potential autophagy genes in wound healing.

Wu YF, Fang DL, Wei J
Annals of translational medicine 2022 Jun;10(12):680

E7-Targeted Nanotherapeutics for Key HPV Afflicted Cervical Lesions by Employing CRISPR/Cas9 and Poly (Beta-Amino Ester).

Xiong J, Tan S, Yu L, Shen H, Qu S, Zhang C, Ren C, Zhu D, Wang H
International journal of nanomedicine 2021;16:7609-7622

SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease.

Li X, Liu T, Wu TT, Feng Y, Peng SJ, Yin H, Wu YC
Frontiers in neurology 2021;12:652882

Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.

Zhang L, Liu M, Liu W, Hu C, Li H, Deng J, Cao Q, Wang Y, Hu W, Li Q
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426

Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells.

Chen X, Huang Y, Gao P, Lv Y, Jia D, Sun K, Han Y, Hu H, Tang Z, Ren X, Liu M
Biomedicines 2021 Nov 16;9(11)

(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.

Chen C, Wang YS, Zhang ET, Li GA, Liu WY, Li Y, Jin YH
International journal of molecular sciences 2021 Dec 6;22(23)

ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.

Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723

In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.

Chen Y, Jiang H, Wang T, He D, Tian R, Cui Z, Tian X, Gao Q, Ma X, Yang J, Wu J, Tan S, Xu H, Tang X, Wang Y, Yu Z, Han H, Das BC, Severinov K, Hitzeroth II, Debata PR, Xu W, Fan W, Jin Z, Cao C, Yu M, Xie W, Huang Z, Hu Z, You Z
Antiviral research 2020 Jun;178:104794

Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.

Kim JY, Jayne LA, Bai Y, Feng MJHH, Clark MA, Chung S, W Christman J, Cianciolo RE, Pabla NS
Biochemical pharmacology 2020 Jul;177:113939

FAIM-S functions as a negative regulator of NF-κB pathway and blocks cell cycle progression in NSCLC cells.

Wang P, Xun W, Han T, Cheng Z
Cell cycle (Georgetown, Tex.) 2020 Dec;19(24):3458-3467

Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.

Huang S, Wang LL, Xue NN, Li C, Guo HH, Ren TK, Zhan Y, Li WB, Zhang J, Chen XG, Han YX, Zhang JL, Jiang JD
Theranostics 2019;9(23):6745-6763

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.

Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J, Wang JB
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032

Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.

Li T, Xiong Y, Wang Q, Chen F, Zeng Y, Yu X, Wang Y, Zhou F, Zhou Y
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011

Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction.

Alam P, Haile B, Arif M, Pandey R, Rokvic M, Nieman M, Maliken BD, Paul A, Wang YG, Sadayappan S, Ahmed RPH, Kanisicak O
Journal of the American Heart Association 2019 Aug 6;8(15):e012089

Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.

Xiong Y, Li T, Assani G, Ling H, Zhou Q, Zeng Y, Zhou F, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602

Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy.

Zhu D, Shen H, Tan S, Hu Z, Wang L, Yu L, Tian X, Ding W, Ren C, Gao C, Cheng J, Deng M, Liu R, Hu J, Xi L, Wu P, Zhang Z, Ma D, Wang H
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Oct 3;26(10):2443-2455

CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A.

Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, Yang D, An S, Lv L, Jiao B, Chen C, Lai R, Shi P, Zhao X
Oncogene 2018 Jan 4;37(1):128-138

PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.

Yang X, Qu S, Wang L, Zhang H, Yang Z, Wang J, Dai B, Tao K, Shang R, Liu Z, Li X, Zhang Z, Xia C, Ma B, Liu W, Li H, Dou K
Oncogene 2018 Dec;37(50):6399-6413

HOXD-AS1 functions as an oncogenic ceRNA to promote NSCLC cell progression by sequestering miR-147a.

Wang Q, Jiang S, Song A, Hou S, Wu Q, Qi L, Gao X
OncoTargets and therapy 2017;10:4753-4763

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.

Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268

Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells.

Liang Z, Li W, Liu J, Li J, He F, Jiang Y, Yang L, Li P, Wang B, Wang Y, Ren Y, Yang J, Luo Z, Vaziri C, Liu P
Scientific reports 2017 Feb 2;7:41776

TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.

Hu Z, Ding W, Zhu D, Yu L, Jiang X, Wang X, Zhang C, Wang L, Ji T, Liu D, He D, Xia X, Zhu T, Wei J, Wu P, Wang C, Xi L, Gao Q, Chen G, Liu R, Li K, Li S, Wang S, Zhou J, Ma D, Wang H
The Journal of clinical investigation 2015 Jan;125(1):425-36

Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway.

Qin G, Xu F, Qin T, Zheng Q, Shi D, Xia W, Tian Y, Tang Y, Wang J, Xiao X, Deng W, Wang S
Oncotarget 2015 Dec 8;6(39):41794-808

Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer.

He D, Wang J, Zhang C, Shan B, Deng X, Li B, Zhou Y, Chen W, Hong J, Gao Y, Chen Z, Duan C
Molecular cancer 2015 Apr 1;14:73

Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK
PloS one 2014;9(5):e96657

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.

Shan X, Fu YS, Aziz F, Wang XQ, Yan Q, Liu JW
PloS one 2014;9(12):e115401

Disruption of HPV16-E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells.

Hu Z, Yu L, Zhu D, Ding W, Wang X, Zhang C, Wang L, Jiang X, Shen H, He D, Li K, Xi L, Ma D, Wang H
BioMed research international 2014;2014:612823

Zinc finger nucleases targeting the human papillomavirus E7 oncogene induce E7 disruption and a transformed phenotype in HPV16/18-positive cervical cancer cells.

Ding W, Hu Z, Zhu D, Jiang X, Yu L, Wang X, Zhang C, Wang L, Ji T, Li K, He D, Xia X, Liu D, Zhou J, Ma D, Wang H
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Dec 15;20(24):6495-503

miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.

Jung HM, Phillips BL, Chan EK
Molecular cancer 2014 Apr 8;13:80

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.

Wang G, Lunardi A, Zhang J, Chen Z, Ala U, Webster KA, Tay Y, Gonzalez-Billalabeitia E, Egia A, Shaffer DR, Carver B, Liu XS, Taulli R, Kuo WP, Nardella C, Signoretti S, Cordon-Cardo C, Gerald WL, Pandolfi PP
Nature genetics 2013 Jul;45(7):739-746

Identification and functional analysis of 9p24 amplified genes in human breast cancer.

Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R, Wicha MS, Ethier SP, Yang ZQ
Oncogene 2012 Jan 19;31(3):333-41

Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.

Hsu TI, Wang MC, Chen SY, Huang ST, Yeh YM, Su WC, Chang WC, Hung JJ
Molecular pharmacology 2012 Dec;82(6):1115-28

Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.

Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S
Cancer 2011 Jan 1;117(1):86-95

AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D.

Zang Y, Yu LF, Nan FJ, Feng LY, Li J
The Journal of biological chemistry 2009 Mar 6;284(10):6175-84

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest.

Sun F, Fu H, Liu Q, Tie Y, Zhu J, Xing R, Sun Z, Zheng X
FEBS letters 2008 Apr 30;582(10):1564-8

Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell.

Liao X, Yang S, Shao Z, Li J, Liu Y, Xiong X, Liu X
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2005;25(6):679-82

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 10048-2-Ig(RB1 antibody) at dilution of 1:3000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-RB1 (IP:10048-2-Ig, 3ug; Detection:10048-2-Ig 1:500) with A431 cells lysate 3000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The RB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RB1. This antibody recognizes human, mouse antigen. The RB1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Appendix: 10048-2-Ig.pdf

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