BS8258
antibody from Bioworld Technology, Inc
Targeting: RFFL
CARP-2, CARP2, fring, rififylin, RNF189, RNF34L
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS8258 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- RFFL polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human RFFL.
- Description
- Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RFFL, also known as RNF189, RNF34L or Rififylin, is a 363 amino acid protein that localizes to both the cytoplasm and to the membrane and contains one FYVE-type zinc finger, one RING-type zinc finger and two SAP domains. Expressed ubiquitously with increased expression in testis, spleen, ovary and prostate, RFFL functions as an E3 ubiquitin-protein ligase that interacts with caspase-8 and caspase-10 and targets them for proteasomal degradation. Multiple isoforms of RFFL exist due to alternative splicing events.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- WesternBlot (WB) analysis of RFFL polyclonal antibody