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- References [21]
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- Product number
- 12683-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12683-1-AP, RRID:AB_2139530
- Product name
- MAD2L2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MAD2L2 antibody (Cat. #12683-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references REV7 associates with ATRIP and inhibits ATR kinase activity.
The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling.
The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling.
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed.
The Immunohistochemical Expression of REV-7 in Various Human Cancer Pathology Specimens: A Systematic Review.
Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer.
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage.
REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis.
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Chromosome alignment-maintaining phosphoprotein CHAMP1 plays a role in cell survival through regulating Mcl-1 expression.
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
CDH1 binds MAD2L2 in a Rev1-like pattern.
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.
Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.
Regulation of error-prone translesion synthesis by Spartan/C1orf124.
REV1 and polymerase ζ facilitate homologous recombination repair.
Biller M, Kabir S, Nipper S, Allen S, Kayali Y, Kuncik S, Sasanuma H, Zhou P, Vaziri C, Tomida J
Nucleic acids research 2026 Jan 14;54(2)
Nucleic acids research 2026 Jan 14;54(2)
The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling.
Chiou LF, Jayaprakash D, Droby GN, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Wu D, Herring LE, Bowser J, Vaziri C
bioRxiv : the preprint server for biology 2025 Jan 9;
bioRxiv : the preprint server for biology 2025 Jan 9;
The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling.
Chiou LF, Droby GN, Jayaprakash D, Anand JR, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Xie J, Wu D, Herring LE, Tomida J, Bowser JL, Vaziri C
Nature communications 2025 Aug 5;16(1):7214
Nature communications 2025 Aug 5;16(1):7214
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed.
Sobkowiak K, Kohzaki M, Böhm R, Mailler J, Huber F, Emamzadah S, Tropia L, Hiller S, Halazonetis TD
Cell reports 2025 Apr 22;44(4):115431
Cell reports 2025 Apr 22;44(4):115431
The Immunohistochemical Expression of REV-7 in Various Human Cancer Pathology Specimens: A Systematic Review.
Spinos T, Goutas D, Driva TS, Zografos E, Gakiopoulou C, Agrogiannis G, Zolota V, Tzelepi V, Manolis I, Koniaris E, Ioannou M, Lazaris AC
Cureus 2024 Jan;16(1):e52542
Cureus 2024 Jan;16(1):e52542
Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer.
Nair JR, Huang TT, Sunkara A, Pruitt MR, Ibanez KR, Chiang CY, Cheng KC, Wilson K, Cardillo TM, Hofsess S, Lee JM
iScience 2024 Dec 20;27(12):111283
iScience 2024 Dec 20;27(12):111283
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Vincendeau E, Wei W, Zhang X, Planchais C, Yu W, Lenden-Hasse H, Cokelaer T, Pipoli da Fonseca J, Mouquet H, Adams DJ, Alt FW, Jackson SP, Balmus G, Lescale C, Deriano L
Nature communications 2022 Jun 28;13(1):3707
Nature communications 2022 Jun 28;13(1):3707
Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage.
Pernicone N, Elias M, Onn I, Tobi D, Listovsky T
Molecules (Basel, Switzerland) 2022 Jan 19;27(3)
Molecules (Basel, Switzerland) 2022 Jan 19;27(3)
REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis.
Chen Y, Jie X, Xing B, Wu Z, Yang X, Rao X, Xu Y, Zhou D, Dong X, Zhang T, Yang K, Li Z, Wu G
Cell death & disease 2022 Feb 3;13(2):110
Cell death & disease 2022 Feb 3;13(2):110
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS.
Bao D, Su H, Lei CT, Tang H, Ye C, Xiong W, He FF, Lin JH, Hammes HP, Zhang C
International journal of biological sciences 2021;17(15):4396-4408
International journal of biological sciences 2021;17(15):4396-4408
Chromosome alignment-maintaining phosphoprotein CHAMP1 plays a role in cell survival through regulating Mcl-1 expression.
Hino M, Iemura K, Ikeda M, Itoh G, Tanaka K
Cancer science 2021 Sep;112(9):3711-3721
Cancer science 2021 Sep;112(9):3711-3721
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.
de Krijger I, Föhr B, Pérez SH, Vincendeau E, Serrat J, Thouin AM, Susvirkar V, Lescale C, Paniagua I, Hoekman L, Kaur S, Altelaar M, Deriano L, Faesen AC, Jacobs JJL
Nature communications 2021 Sep 14;12(1):5421
Nature communications 2021 Sep 14;12(1):5421
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
Zhang J, Zou L, Shi D, Liu J, Zhang J, Zhao R, Wang G, Zhang L, Ouyang L, Liu B
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
Song AN, Yin XJ, Gao P, Tang H, Meng XF, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
CDH1 binds MAD2L2 in a Rev1-like pattern.
Pernicone N, Grinshpon S, Listovsky T
Biochemical and biophysical research communications 2020 Oct 22;531(4):566-572
Biochemical and biophysical research communications 2020 Oct 22;531(4):566-572
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
Gray S, Santiago ER, Chappie JS, Cohen PE
Cell reports 2020 Jul 7;32(1):107858
Cell reports 2020 Jul 7;32(1):107858
MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.
Li Y, Li L, Chen M, Yu X, Gu Z, Qiu H, Qin G, Long Q, Fu X, Liu T, Li W, Huang W, Shi D, Kang T, Luo M, Wu X, Deng W
Molecular oncology 2018 Mar;12(3):391-405
Molecular oncology 2018 Mar;12(3):391-405
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.
Tomida J, Takata K, Lange SS, Schibler AC, Yousefzadeh MJ, Bhetawal S, Dent SY, Wood RD
Nucleic acids research 2015 Jan;43(2):1000-11
Nucleic acids research 2015 Jan;43(2):1000-11
Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.
Listovsky T, Sale JE
The Journal of cell biology 2013 Oct 14;203(1):87-100
The Journal of cell biology 2013 Oct 14;203(1):87-100
Regulation of error-prone translesion synthesis by Spartan/C1orf124.
Kim MS, Machida Y, Vashisht AA, Wohlschlegel JA, Pang YP, Machida YJ
Nucleic acids research 2013 Feb 1;41(3):1661-8
Nucleic acids research 2013 Feb 1;41(3):1661-8
REV1 and polymerase ζ facilitate homologous recombination repair.
Sharma S, Hicks JK, Chute CL, Brennan JR, Ahn JY, Glover TW, Canman CE
Nucleic acids research 2012 Jan;40(2):682-91
Nucleic acids research 2012 Jan;40(2):682-91
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MAD2L2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MAD2L2. This antibody recognizes human,mouse,rat antigen. The MAD2L2 antibody has been validated for the following applications: ELISA, WB analysis.
