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- Antibody Data
- Antigen structure
- References [23]
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- Product number
- ABIN182433 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-GLI Family Zinc Finger 2 (GLI2) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- The immunogen for anti-GLI2 antibody: synthetic peptide directed towards the N terminal of human GLI2
- Description
- Protein A purified
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
RNDVHLRTPLLKENGDSEAGTEPGGPESTEASSTS
QAVED CLHVRAIKTE- Epitope
- N-Term
- Vial size
- 100 μg
- Concentration
- 1mg/mL
- Storage
- -20°C
- Handling
- Avoid repeated freeze-thaw cycles.
Submitted references Targeting Gli transcription activation by small molecule suppresses tumor growth.
Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells.
Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.
Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus.
Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.
Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma.
Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor.
Identification of the cell lineage at the origin of basal cell carcinoma.
Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.
Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.
GSK-3 is a master regulator of neural progenitor homeostasis.
Role for hedgehog pathway in regulating growth and function of invariant NKT cells.
Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells.
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity.
FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.
Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery.
Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas.
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.
Bosco-Clément G, Zhang F, Chen Z, Zhou HM, Li H, Mikami I, Hirata T, Yagui-Beltran A, Lui N, Do HT, Cheng T, Tseng HH, Choi H, Fang LT, Kim IJ, Yue D, Wang C, Zheng Q, Fujii N, Mann M, Jablons DM, He B
Oncogene 2014 Apr 17;33(16):2087-97
Oncogene 2014 Apr 17;33(16):2087-97
Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cells.
Li Y, Drnevich J, Akraiko T, Band M, Li D, Wang F, Matoba R, Tanaka TS
Genomics 2013 Nov-Dec;102(5-6):456-67
Genomics 2013 Nov-Dec;102(5-6):456-67
Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.
Tostar U, Finta C, Rahman MF, Shimokawa T, Zaphiropoulos PG
PloS one 2012;7(5):e37761
PloS one 2012;7(5):e37761
Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus.
Yang L, Wang LS, Chen XL, Gatalica Z, Qiu S, Liu Z, Stoner G, Zhang H, Weiss H, Xie J
International journal of biochemistry and molecular biology 2012;3(1):46-57
International journal of biochemistry and molecular biology 2012;3(1):46-57
Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.
Jung IH, Jung DE, Park YN, Song SY, Park SW
PloS one 2011;6(12):e27941
PloS one 2011;6(12):e27941
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.
Malek R, Matta J, Taylor N, Perry ME, Mendrysa SM
PloS one 2011 Mar 18;6(3):e17884
PloS one 2011 Mar 18;6(3):e17884
Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma.
Coon V, Laukert T, Pedone CA, Laterra J, Kim KJ, Fults DW
Molecular cancer therapeutics 2010 Sep;9(9):2627-36
Molecular cancer therapeutics 2010 Sep;9(9):2627-36
Involvement of PTCH1 mutations in the calcifying epithelial odontogenic tumor.
Peacock ZS, Cox D, Schmidt BL
Oral oncology 2010 May;46(5):387-92
Oral oncology 2010 May;46(5):387-92
Identification of the cell lineage at the origin of basal cell carcinoma.
Youssef KK, Van Keymeulen A, Lapouge G, Beck B, Michaux C, Achouri Y, Sotiropoulou PA, Blanpain C
Nature cell biology 2010 Mar;12(3):299-305
Nature cell biology 2010 Mar;12(3):299-305
Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.
Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, Kawamoto T, Koizumi K, Sato K, Fujiya M, Sasaki K, Tanno S, Okumura T, Shimizu N, Kawabe J, Karasaki H, Kono T, Ii M, Bardeesy N, Chung DC, Kohgo Y
PloS one 2010 Jan 21;5(1):e8824
PloS one 2010 Jan 21;5(1):e8824
Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.
Kim JE, Singh RR, Cho-Vega JH, Drakos E, Davuluri Y, Khokhar FA, Fayad L, Medeiros LJ, Vega F
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009 Oct;22(10):1312-20
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009 Oct;22(10):1312-20
GSK-3 is a master regulator of neural progenitor homeostasis.
Kim WY, Wang X, Wu Y, Doble BW, Patel S, Woodgett JR, Snider WD
Nature neuroscience 2009 Nov;12(11):1390-7
Nature neuroscience 2009 Nov;12(11):1390-7
Role for hedgehog pathway in regulating growth and function of invariant NKT cells.
Syn WK, Witek RP, Curbishley SM, Jung Y, Choi SS, Enrich B, Omenetti A, Agboola KM, Fearing CM, Tilg H, Adams DH, Diehl AM
European journal of immunology 2009 Jul;39(7):1879-92
European journal of immunology 2009 Jul;39(7):1879-92
Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells.
Takanaga H, Tsuchida-Straeten N, Nishide K, Watanabe A, Aburatani H, Kondo T
Stem cells (Dayton, Ohio) 2009 Jan;27(1):165-74
Stem cells (Dayton, Ohio) 2009 Jan;27(1):165-74
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity.
Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y, Kageyama R, Wallace VA
The Journal of cell biology 2009 Jan 12;184(1):101-12
The Journal of cell biology 2009 Jan 12;184(1):101-12
FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.
Madison BB, McKenna LB, Dolson D, Epstein DJ, Kaestner KH
The Journal of biological chemistry 2009 Feb 27;284(9):5936-44
The Journal of biological chemistry 2009 Feb 27;284(9):5936-44
Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.
Ho L, Stojanovski A, Whetstone H, Wei QX, Mau E, Wunder JS, Alman B
Cancer cell 2009 Aug 4;16(2):126-36
Cancer cell 2009 Aug 4;16(2):126-36
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.
Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM
Gut 2008 Sep;57(9):1275-82
Gut 2008 Sep;57(9):1275-82
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM
The Journal of clinical investigation 2008 Oct;118(10):3331-42
The Journal of clinical investigation 2008 Oct;118(10):3331-42
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery.
Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE
The Journal of cell biology 2008 Mar 10;180(5):897-904
The Journal of cell biology 2008 Mar 10;180(5):897-904
Amelogenin positive cells scattered in the interstitial component of odontogenic fibromas.
Kabasawa Y, Nagumo K, Takeda Y, Kawashima N, Okada N, Omura K, Yamaguchi A, Katsube K
Journal of clinical pathology 2008 Jul;61(7):851-5
Journal of clinical pathology 2008 Jul;61(7):851-5
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.
Kim Y, Yoon JW, Xiao X, Dean NM, Monia BP, Marcusson EG
Cancer research 2007 Apr 15;67(8):3583-93
Cancer research 2007 Apr 15;67(8):3583-93
GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.
Ikram MS, Neill GW, Regl G, Eichberger T, Frischauf AM, Aberger F, Quinn A, Philpott M
The Journal of investigative dermatology 2004 Jun;122(6):1503-9
The Journal of investigative dermatology 2004 Jun;122(6):1503-9
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