Antibody data
- Antibody Data
- Antigen structure
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- Product number
- FNab06217 - Provider product page
- Provider
- FineTest Biotech
- Product name
- PCNA antibody
- Antibody type
- Monoclonal
- Antigen
- Recombinant protein fragment
- Description
- Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic(AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response(DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways(PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion(TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
- Reactivity
- Human, Mouse, Rat, Rabbit
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
proliferating cell nuclear antigen
- Epitope
- IgG1
- Isotype
- IgG
- Antibody clone number
- 8F9
- Vial size
- 100¦Ìg
- Concentration
- Protein A+G purification
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
- Handling
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
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