Antibody data
- Antibody Data
- Antigen structure
- References [35]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 22474-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- FOXA2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FOXA2 antibody (Cat. #22474-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice.
YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.
Glycyrrhizic acid combined with human adipose-derived MSCs synergistically alleviates the MPP+/MPTP-induced parkinson's disease by inducing autophagy through PI3K/AKT/HIF-1α pathway.
Baicalin inhibits LPS-induced apoptosis and inflammation in WI- 38 cells by promoting FOXA2/TRIM27 Interaction: Implications for pediatric pneumonia mechanisms.
FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation.
Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence.
GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer.
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
FOXA2 Loss in TGF-β1-Induced EMT Suppresses Bisecting-GlcNAc N-Glycan Synthesis in Lung Adenocarcinoma.
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer.
Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy.
NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression.
L1CAM mediates neuroendocrine phenotype acquisition in prostate cancer cells.
Slit3 by PTH-Induced Osteoblast Secretion Repels Sensory Innervation in Spine Porous Endplates to Relieve Low Back Pain.
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
Interleukin-33 promotes intrauterine adhesion formation in mice through the mitogen-activated protein kinase signaling pathway.
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease.
FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion.
METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells.
Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.
An artificial LAMA2-GelMA hydrogel microenvironment for the development of pancreatic endocrine progenitors.
Forkhead box A2 transcriptionally activates hsa-let-7 g to inhibit hypoxia-induced epithelial-mesenchymal transition by targeting c14orf28 in colorectal cancer.
Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription.
Changes in the hepatic differentiation potential of human mesenchymal stem cells aged in vitro.
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Functional hit 1 (FH1)-based rapid and efficient generation of functional hepatocytes from human mesenchymal stem cells: a novel strategy for hepatic differentiation.
Comparative cytotoxicity studies of halophenolic disinfection byproducts using human extended pluripotent stem cells.
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer.
Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.
EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways.
Upregulated forkhead-box A3 elevates the expression of forkhead-box A1 and forkhead-box A2 to promote metastasis in esophageal cancer.
Early prediction of the differentiation potential during the formation of human iPSC-derived embryoid bodies.
Kittane S, Ladewig E, Li T, Love JR, Blawski R, Gao Y, Arruabarrena-Aristorena A, Zhao P, Dalrymple SL, Liu H, Guo X, Sallaku M, Kelkar N, Garcia-Martinez L, Carmona Sanz J, Chen W, Stoudmann C, Baldino L, Razavi-Mohseni M, Kalemi I, Beer MA, Castel P, Brennen WN, Scaltriti M, Morey L, Cocco E, Ji H, Chan HM, Battle A, Leslie CS, Karthaus WR, Toska E
Cancer research 2026 Mar 2;86(5):1113-1131
Cancer research 2026 Mar 2;86(5):1113-1131
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice.
Zhang W, Otte AD, Wang Z, Barik SK, Wan M, Cao X, Crane JL
Bone research 2026 Jan 22;14(1):12
Bone research 2026 Jan 22;14(1):12
YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis.
Li X, Li X, Liu C, Li Z, Ding K, Wang Y, Gu N, Xie L, Chen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e05725
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e05725
Glycyrrhizic acid combined with human adipose-derived MSCs synergistically alleviates the MPP+/MPTP-induced parkinson's disease by inducing autophagy through PI3K/AKT/HIF-1α pathway.
Yu X, Fang Y, Zhang J, Li W, Zhang Y, Cui Q, Liu X, Jiang Y, Liu Q, Xu C, Jiang B, Lu Y
Stem cell research & therapy 2025 Sep 25;16(1):500
Stem cell research & therapy 2025 Sep 25;16(1):500
Baicalin inhibits LPS-induced apoptosis and inflammation in WI- 38 cells by promoting FOXA2/TRIM27 Interaction: Implications for pediatric pneumonia mechanisms.
Gao L, Zeng X, Huang Y, Huang L
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):14131-14142
Naunyn-Schmiedeberg's archives of pharmacology 2025 Oct;398(10):14131-14142
FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation.
Zeng H, Wang B, Huang Z, Gao L, Xiao Y, Liu X, Xu Y, Hu Z, Pang J, Yu Y, Guo Y, Wu W
Journal of neuroinflammation 2025 Nov 26;22(1):280
Journal of neuroinflammation 2025 Nov 26;22(1):280
Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction.
Villedieu A, Alegria-Prévot O, Phan C, Ieda Y, Corson F, Gros J
Nature communications 2025 Nov 25;16(1):11616
Nature communications 2025 Nov 25;16(1):11616
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.
Son SM, Siddiqi FH, Lopez A, Ansari R, Tyrkalska SD, Park SJ, Kunath T, Metzakopian E, Fleming A, Rubinsztein DC
Neuron 2025 Jun 18;113(12):1908-1924.e13
Neuron 2025 Jun 18;113(12):1908-1924.e13
Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence.
Cui Z, Li J, Li C, Deng S, Liu W, Lei T, Cao J, Wang Z, Wang X, Ma S, Zhu Y, Yang H, Chen P
Cell reports 2025 Jul 22;44(7):115917
Cell reports 2025 Jul 22;44(7):115917
GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer.
Xie M, Qin H, Liu L, Wu J, Zhao Z, Zhao Y, Fang Y, Yu X, Su C
Journal of experimental & clinical cancer research : CR 2025 Feb 19;44(1):61
Journal of experimental & clinical cancer research : CR 2025 Feb 19;44(1):61
Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.
Hu X, Li J, Ding C, Jiang J, Xia W, Lu J, Su H, Zhang M, Li H, Liu JL, Lin Y, Meng Q, Huang B
Communications biology 2025 Feb 11;8(1):215
Communications biology 2025 Feb 11;8(1):215
FOXA2 Loss in TGF-β1-Induced EMT Suppresses Bisecting-GlcNAc N-Glycan Synthesis in Lung Adenocarcinoma.
Ge W, Wen S, Zhou X, Chen Y, Zeng D, Jiang J, Yang S
Proteomics 2025 Apr;25(8):e202400216
Proteomics 2025 Apr;25(8):e202400216
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer.
Wang Z, Townley SL, Zhang S, Liu M, Li M, Labaf M, Patalano S, Venkataramani K, Siegfried KR, Macoska JA, Han D, Gao S, Risbridger GP, Taylor RA, Lawrence MG, He HH, Selth LA, Cai C
Nature communications 2024 Jun 8;15(1):4914
Nature communications 2024 Jun 8;15(1):4914
Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy.
Zhang D, Ma B, Liu D, Wu W, Zhou T, Gao Y, Yang C, Jian Y, Fan Y, Qian Y, Ma J, Gao Y, Chen Y, Xu S, Li L
EBioMedicine 2024 Jul;105:105212
EBioMedicine 2024 Jul;105:105212
NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression.
Xing M, Yao B, Xu J, Lu P, Li Q, Wu D, Chen B, Wei J, Su L, Zhao Q
iScience 2024 Feb 16;27(2):108840
iScience 2024 Feb 16;27(2):108840
L1CAM mediates neuroendocrine phenotype acquisition in prostate cancer cells.
Hsieh CL, Do AD, Hsueh CY, Raboshakga MO, Thanh TN, Tai TT, Kung HJ, Sung SY
The Prostate 2024 Dec;84(16):1434-1447
The Prostate 2024 Dec;84(16):1434-1447
Slit3 by PTH-Induced Osteoblast Secretion Repels Sensory Innervation in Spine Porous Endplates to Relieve Low Back Pain.
Crane J, Zhang W, Otte A, Barik S, Wan M, Cao X
Research square 2024 Aug 31;
Research square 2024 Aug 31;
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
Zheng JH, Zhu YH, Yang J, Ji PX, Zhao RK, Duan ZH, Yao HF, Jia QY, Yin YF, Hu LP, Li Q, Jiang SH, Huo YM, Liu W, Sun YW, Liu DJ
Cell reports 2024 Aug 27;43(8):114633
Cell reports 2024 Aug 27;43(8):114633
Interleukin-33 promotes intrauterine adhesion formation in mice through the mitogen-activated protein kinase signaling pathway.
Liu D, Yuan L, Xu F, Ma Y, Zhang H, Jin Y, Chen M, Zhang Z, Luo S
Communications biology 2024 Aug 20;7(1):1022
Communications biology 2024 Aug 20;7(1):1022
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease.
Tang C, Deng X, Qu J, Miao Y, Tian L, Zhang M, Li X, Sun B, Chen L
Drug design, development and therapy 2023;17:1503-1514
Drug design, development and therapy 2023;17:1503-1514
FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion.
Lee MR, Shin JY, Kim MY, Kim JO, Jung CK, Kang J
American journal of cancer research 2023;13(2):638-653
American journal of cancer research 2023;13(2):638-653
METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells.
Mu M, Li X, Dong L, Wang J, Cai Q, Hu Y, Wang D, Zhao P, Zhang L, Zhang D, Cheng S, Tan L, Wu F, Shi YG, Xu W, Shi Y, Shen H
Cell reports 2023 Jun 27;42(6):112650
Cell reports 2023 Jun 27;42(6):112650
Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.
Sun X, Kato H, Sato H, Han X, Hirofuji Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K
FASEB bioAdvances 2022 Jul;4(7):454-467
FASEB bioAdvances 2022 Jul;4(7):454-467
An artificial LAMA2-GelMA hydrogel microenvironment for the development of pancreatic endocrine progenitors.
Huang Y, Xu Y, Zhu J, Wan J, Xiong Y, Jiang Z, Zhu S, Guo Q, Li Y, Lu Y, Yu B, Guo Y, Wang Z, Yang Y
Biomaterials 2022 Dec;291:121882
Biomaterials 2022 Dec;291:121882
Forkhead box A2 transcriptionally activates hsa-let-7 g to inhibit hypoxia-induced epithelial-mesenchymal transition by targeting c14orf28 in colorectal cancer.
Ouyang C, Fu Q, Xie Y, Xie J
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2022 Aug;23(3):188-194
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2022 Aug;23(3):188-194
Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription.
Chen Z, Xiang L, Hu Z, Ou H, Liu X, Yu L, Chen W, Jiang L, Yu Q, Fang Y, Xu Y, Liu Q, Huang Y, Li X, Yang D
American journal of cancer research 2021;11(1):277-296
American journal of cancer research 2021;11(1):277-296
Changes in the hepatic differentiation potential of human mesenchymal stem cells aged in vitro.
Luo S, Xiao S, Ai Y, Wang B, Wang Y
Annals of translational medicine 2021 Nov;9(21):1628
Annals of translational medicine 2021 Nov;9(21):1628
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Functional hit 1 (FH1)-based rapid and efficient generation of functional hepatocytes from human mesenchymal stem cells: a novel strategy for hepatic differentiation.
Luo S, Ai Y, Xiao S, Wang B, Wang Y
Annals of translational medicine 2021 Jul;9(13):1087
Annals of translational medicine 2021 Jul;9(13):1087
Comparative cytotoxicity studies of halophenolic disinfection byproducts using human extended pluripotent stem cells.
Liu Y, Zhu D, Zhao Z, Zhou Q, Pan Y, Shi W, Qiu J, Yang Y
Chemosphere 2021 Jan;263:127899
Chemosphere 2021 Jan;263:127899
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer.
Teng S, Li YE, Yang M, Qi R, Huang Y, Wang Q, Zhang Y, Chen S, Li S, Lin K, Cao Y, Ji Q, Gu Q, Cheng Y, Chang Z, Guo W, Wang P, Garcia-Bassets I, Lu ZJ, Wang D
Cell research 2020 Jan;30(1):34-49
Cell research 2020 Jan;30(1):34-49
Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.
Ke M, Chong CM, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu JH, Yao X, Qin D, Su H
Cell death & disease 2020 Feb 18;11(2):130
Cell death & disease 2020 Feb 18;11(2):130
EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways.
Yang L, Zhu Y, Kong D, Gong J, Yu W, Liang Y, Nie Y, Teng CB
International journal of biological sciences 2019;15(12):2561-2575
International journal of biological sciences 2019;15(12):2561-2575
Upregulated forkhead-box A3 elevates the expression of forkhead-box A1 and forkhead-box A2 to promote metastasis in esophageal cancer.
Chen B, Yu J, Lu L, Dong F, Zhou F, Tao X, Sun E
Oncology letters 2019 May;17(5):4351-4360
Oncology letters 2019 May;17(5):4351-4360
Early prediction of the differentiation potential during the formation of human iPSC-derived embryoid bodies.
Guo NN, Liu LP, Zhang YX, Cai YT, Guo Y, Zheng YW, Li YM
Biochemical and biophysical research communications 2019 Aug 27;516(3):673-679
Biochemical and biophysical research communications 2019 Aug 27;516(3):673-679
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 22474-1-AP( FOXA2 Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- IP Result of anti-FOXA2 (IP:22474-1-AP, 3ug; Detection:22474-1-AP 1:300) with HepG2 cells lysate 1920ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The FOXA2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FOXA2. This antibody recognizes human antigen. The FOXA2 antibody has been validated for the following applications: ELISA, IP, WB, IHC analysis.