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- Antibody Data
- Antigen structure
- References [4737]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 50599-2-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#50599-2-Ig, RRID:AB_2061561
- Product name
- BAX antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BAX antibody (Cat. #50599-2-Ig) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis.
AVN944 Elicits Apoptotic Responses and Impedes Tumorigenic Potential in Ewing's Sarcoma Cells.
Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity.
Knockdown of miR-21-5P targets and regulates PDCD4-induced apoptosis in ovarian granulosa cells and ameliorates in sulin resistance in polycystic ovary syndrom.
Exosome encapsulated albumin nanoparticles target delivery of DBET6 as a treatment for triple-negative breast cancer.
Glioma Cell Membrane-Coated CaCO(3) Nanoparticles for Localized Postoperative Chemo-Calcium Overload Therapy to Prevent Glioma Recurrence.
CD44 Receptor-Mediated Delivery of ROS/pH Dual-Sensitive Nanoparticles Based on Poly(Ethylene Glycol)-b-Poly(Doxorubicin)-b-Hyaluronic Acid Copolymer.
Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4(+) T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
Obacunone Promotes Functional Recovery After Spinal Cord Injury by Attenuating Neuroinflammation by Targeting the TLR4/MyD88/p38 MAPK Pathway.
Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
Combined Treatment with Shuyu Pills and Everolimus Suppresses Triple-Negative Breast Cancer Growth via the PI3K/AKT/mTOR Pathway.
TIGIT impairs NK cell antifibrotic activity through the IFNγ-IFI30 axis in schistosomiasis-induced liver fibrosis.
Dietary dihydroquercetin alleviates age-related cognitive impairment in association with modulation of apoptosis and pyroptosis pathways.
SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway.
Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2.
Electroacupuncture reduces calcium influx and inhibits endoplasmic reticulum stress by inhibiting the PKCδ-TRPA1 pathway to promote motor function recovery after spinal cord injury.
Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes.
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Pressurized intraperitoneal cold atmospheric plasma as a novel therapeutic strategy for peritoneal metastatic carcinoma.
The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study.
PLOD2 Promotes Cutaneous Squamous Cell Carcinoma Progression in Association With STAT3-Related ERK and AKT Pathways.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
miR-329-3p derived from mast cells-exosomes exacerbates intestinal ischemia-reperfusion injury by targeting ATG10 to regulate autophagy.
VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway.
Near-infrared photobiomodulation can alleviate chemotherapy-induced peripheral neuropathy-associated sensory abnormalities.
m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop.
Echinacoside regulates the IRE1/XBP1 signaling pathway through HSP72 to reduce endoplasmic reticulum stress and improve diabetic kidney disease.
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.
Exosomes derived from Bcl-2-engineered iPSC-cardiomyocytes mitigate aortic valve calcification and inhibit cardiomyocyte apoptosis.
Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis.
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis.
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE.
Modified Banxia Xiexin Decoction promotes mitochondrial fission in colon cancer cells by inhibiting the CHD6-TMEM65 axis.
The C3-C3aR axis drives rotenone-induced cognitive damage via synaptic engulfment, dark microglia and PANoptosis.
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Therapeutic effect of oleanolic acid on hyperthyroid rats through TLR4/NF-κB pathway.
Sulforaphane Attenuates Methamphetamine-Induced Neurotoxicity via Activation of the PI3K/AKT Pathway.
BNIP3L-Mediated Mitophagy Inhibits Cadmium-Induced Apoptosis in the Rat Cerebral Cortex.
Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.
CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis.
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
TPPU alleviates hepatic ischemia-reperfusion injury by regulating macrophage polarization.
Cell-free supernatant of Clostridium butyricum induces mitochondrial apoptosis and suppresses NF-κB pathway in colorectal cancer cells.
Vanadyl Acetylacetonate and Berberine Synergistically Ameliorate Diabetes-induced Vascular Dysfunction and Reduce Endothelial Toxicity through ERK and Akt Regulation.
Alginate Oligosaccharide Alleviates Salmonella Typhimurium-Induced Liver Injury by Regulating Oxidative Stress, Apoptosis, and Inflammatory Signaling Pathway.
A triple combination strategy for nasopharyngeal carcinoma: Aptamer-guided liposomal chemotherapy, engineered NK cells, and Fc-enhanced PD-L1 antibody therapy.
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats.
Targeted Degradation of eEF2K by a Structure-Guided PROTAC Strategy for the Treatment of Triple-Negative Breast Cancer.
Gallium-Doped MXene Nanozymes Protect Liver Through Multi-Death Pathway Blockade and Hepatocyte Regeneration.
Study on the Mechanism of Paeoniflorin, an Active Component of Paeonia lactiflora Pall., in Improving Skin Pigmentation by Inhibiting the TNF-α Signaling Pathway.
Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage.
Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing.
A novel rhein derivative Y01 inhibits hepatocellular carcinoma by inducing apoptosis through regulating PI3K/AKT/mTOR pathway.
Citronellol potentiates sunitinib efficacy in renal cell carcinoma by targeting JAK2/STAT3 signaling pathway.
Yixinshu attenuates myocardial infarction via SHP1/JAK2/STAT3-mediated regulation of mitochondrial function and apoptosis.
Phellopterin Inhibits Inflammation and Relieves Cartilage Degradation by Suppressing MAPK Signaling in Osteoarthritis.
CSF1 regulates inflammation and apoptosis in intervertebral disc degeneration.
DUSP4 mitigates doxorubicin-induced cardiotoxicity via the p38 MAPK/MK2 signaling pathway.
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis.
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2.
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis.
Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
Ginsenoside Suppresses Triple-Negative Breast Cancer Growth and Synergizes With Programmed Cell Death Protein 1 (PD-1) Immunotherapy Through Gut Microbiota and Metabolic Regulation.
A novel chassis for high-quality recombinant protein expression: apoptosis pathway engineering via multi-gene knockout and efficacy improvement of CHO cells.
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
SGK1 Is Upregulated in Retained Placenta and Mediates Estradiol Effects in Bovine Endometrial Cells.
LncRNA H19 overexpression protects against acute kidney injury after cardiopulmonary bypass via activating Pink1/Parkin-mediated mitophagy.
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling.
PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Comprehensively exploring the roles of MAGEA1 in cryptorchidism and its related transcription factor regulatory network.
Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation.
Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.
Study on the effects and mechanisms of M2 macrophages on PYCR1-promoted biological behavior of hepatocellular carcinoma cells.
Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation.
Enzalutamide effectively inhibits the growth of meningiomas via p21-dependent senescence induction.
Maresin-1 Alleviates Sepsis-Induced Liver Injury by Regulating Apoptosis and Autophagy via Activation of the PI3K/Akt Signaling Pathway in Mice.
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
Dietary semen cuscuta improves laying performance by stabilizing mitochondria-associated membranes (MAMs) and inhibiting granulosa cell apoptosis in laying hens.
circKANSL1 promotes immature porcine Sertoli cell growth via recruiting the Vimentin to enhance its parental gene KANSL1 expression.
Butyrate protects against Klebsiella pneumoniae-induced oxidative stress in alveolar macrophages via p62-Keap1-Nrf2 pathway.
Mesenchymal Stem Cell-Lysate Sustained-Release Nano-Hydrogel Alleviates Spinal Cord Injury by Inhibiting Ferroptosis and Mitochondrial Intrinsic Apoptosis.
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Silencing of MAT2A inhibits gastric cancer cell proliferation, migration, and invasion through activation of the p53 pathway.
Skin commensal Cutibacterium acnes alleviates UVB-induced solar dermatitis via ceramide-mediated TLR4-MyD88-NF-κB.
OXCT1-induced succinylation at K81 shields HADH from HSPA8-Mediated degradation in alveolar epithelial cells to attenuate lung ischemia-reperfusion injury.
TIMM23-ERAL1 Axis: A novel regulator of mitochondrial apoptosis in hepatocellular carcinoma.
Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Intermittent fasting attenuates ovarian chronic inflammation in obese mice by inhibiting the CXCL12-CXCR4 axis.
Exploring the mechanism of Bushen KaiXuan Tongluo formula in ameliorating diabetic kidney disease based on transcriptomics and animal experiments.
Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis.
Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways.
The function and molecular mechanism of HIF-1α interacted with p-STAT3 in promoting G6PD overexpression in chronic myelogenous leukemia cells.
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.
Aspirin's therapeutic mechanism against diesel particulate matter-induced lung injury revealed by network pharmacology and experimental models.
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Mechanistic Insights Into Astragali Radix n-Butanol on Podocyte Injury via Cell Cycle Regulation.
Screening of Antiaging Active Components of Morinda officinalis and the Mechanism of Enhanced Efficacy After Salt-Steaming.
Plantaginis Semen, a Novel Natural S1PR1 Agonist, Inhibits Oxidative Stress and Inflammation to Treat Lipopolysaccharide-Induced Acute Lung Injury.
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.
Subcutaneous Implantation of Exogenous Melatonin Induces a Polarization Effect on the Weight of Scent Glands in Muskrat.
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway.
Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation.
Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction.
Diterpenoids and sesquiterpenoids from Euphorbia helioscopia and their neuroprotective activity.
Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress.
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Pyraclostrobin induces brain oxidative stress, apoptosis and inflammation through mitochondrial phosphorylation-induced ROS activation of the p38 MAPK pathway.
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway.
Macrophage migration inhibitory factor alleviates irradiation induced apoptosis of BMSCs through the LncRNA MEG3/NOX4 axis.
Unraveling the role of host kinase PIM1 in Toxoplasma gondii infection: Implications for therapies.
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
Canagliflozin inhibits p38MAPK signaling to protect tubular epithelial cell against pyroptosis in sepsis-induced acute kidney injury.
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways.
SMART-guided discovery of Sarpagine-type monoterpene indole alkaloids from Rauvolfia vomitoria and the synergistic effects with cisplatin against human ovarian cancer cells.
Unraveling the neuroprotective mechanism of gastrodin against CRS-induced depression in adult male mice via Notch3: Integration of proteomics, transcriptomics, molecular docking, and cellular validation.
Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells.
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H(2)O(2)-Damaged PC12 Cells.
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Injectable BMSC-Based Extracellular Matrix-Mimicking Microtissue for Myocardial Infarction Repair.
USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.
Effect of selenium-enriched Ganoderma lucidum powder in testicular tissues, oxidative stress biomarkers and antiapoptotic capacities in roosters.
Ssc-miR-130b Inhibits Lipid Accumulation in Porcine Intramuscular Preadipocytes by Activating Apoptosis via Bcl-2/Bax/Caspase-3 Signaling Pathway.
FTO-Eci1 Axis Mediates Exercise-Induced Cardioprotection in Pressure Overload Mice.
Subchronic exposure to T-2 toxin triggered neurobehavioral damage in developing juvenile rats was associated with oxidative stress and mitochondrial pathway-induced apoptosis of hippocampal neurons.
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
GJB2 c.109G > A mutation activating IFI27-mediated mitochondrial apoptosis pathway leading to hereditary non-syndromic hearing loss.
Rhodotorula mucilaginosa JAASSRY1 Ameliorates Cyclophosphamide-Induced Immunosuppression by Regulating Gut Microbiota and Activation of Spleen TLR4/MyD88/NF-κB Pathway.
NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis.
Exploring the molecular function of LYPD3 from pan-cancer to lung cancer: based on bioinformatics and cellular experiments.
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation.
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis.
Pharmacologic Modulation of the PAR-2-ERK Axis by Statins Converts Inflammatory Survival Signalling into Apoptosis in Colorectal Cancer Cells.
Lactate attenuates hepatic ischemia-reperfusion injury by reducing intrahepatic inflammation and suppressing hepatocyte-neutrophil interaction via the IL-33/ST2 pathway.
IL-24 ameliorates cognitive dysfunction via the inhibition PERK-eIF2α Signaling pathway in Alzheimer's disease.
MMSA-1 is regulated by Wnt/TCF4 and involved in multiple myeloma progression and invasion via RAS/RAF signaling pathway.
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway.
Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway.
Dental pulp stem cell-derived exosomes promote axonal repair in spinal cord injury by suppressing neuroinflammation and apoptosis.
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.
Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation.
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer.
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis.
Cycloastragenol Regulates Mitochondrial Homeostasis-Mediated Renal Tubular Injury to Ameliorate Diabetic Kidney Disease by Directly Targeting ERK to Modulate TFEB.
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway.
ELF5 modulates casein synthesis in goat mammary epithelial cells via JAK2/STAT5 signaling pathway.
A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation.
CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation.
Novel Glycyrrhizinic Acid Derivative YCY-20 Inhibits Cerebral Ischemia/Reperfusion Induced Apoptosis via the AGE-RAGE/MAPK Pathway.
Bacteroides acidifaciens alleviates high-fat diet-induced obesity-related osteoporosis by regulating gut microbiota and bile acid metabolism via the gut-bone axis.
Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway.
Zinc Alleviates Oxidative Stress Injury of the Testis Induced by Zearalenone through Sirt3-Foxo3 Pathway in Mice.
OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis.
DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
COPD airway epithelial cells-derived extracellular vesicles contribute to endothelial dysfunction and atherosclerosis via the miR-141-3p/PDCD4 axis.
UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation.
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Ginsenoside Rg5 Targets PRDX1 to Disrupt Redox Homeostasis and Induce Mitochondria-Dependent Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.
Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.
Bioinformatic analysis and cellular functional assays uncover the role of NXPH4 in breast cancer.
Single-Nucleus RNA Sequencing Reveals SPP1(+) Macrophages Induce Cardiomyocyte Apoptosis to Promote Atrial Fibrillation Susceptibility.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Lidocaine potentiates thermal ablation in cholangiocarcinoma by modulating TRPV6-Driven Ca(2+)/PI3K/AKT/HSF-1 signaling pathway.
Resveratrol and AG490 Overcome Glioblastoma Cells' Resistance to Monotherapy by Inhibiting JAK2/STAT3 Signalling Pathway.
Pulsatilla Saponin B4 Alleviates H(2)O(2)-Induced Oxidative Stress and Apoptosis via the AMPK/Nrf2 Pathway in Bovine Mammary Epithelial Cell Models.
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
A novel molecule ZYZ329 targeting histone methyltransferase SMYD3 suppresses pathological angiogenesis via the driven mitochondrial ROS/HIF-1α/VEGFA axis.
A stimuli-responsive mitochondria-targeted nanoplatform for glioblastoma therapy: modulating the blood-brain barrier and delivering precise chemotherapy.
DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma.
Growth differentiation factor 15 promotes the malignant progression of multiple myeloma via activation of PI3K/Akt/NF-κB signaling pathway.
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway.
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.
Integrated Analysis of Transcriptome and sRNA Sequencing Reveals Mmu-miR-503-5p Regulates the Aluminum Chloride Stress Response of GC-1spg Cells by Targeting Islr.
Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.
14-3-3β knockdown inhibits migration and colony formation of esophageal squamous cell carcinoma cells and is associated with weakened p-AKT signaling.
Pseudolaric acid B promotes lung cancer cells ferroptosis depending on JNK/ERK-mediated upregulation of survivin.
Qingyu Yangjing formula ameliorates cyclophosphamide-induced oligoasthenospermia by regulating the hypothalamic-pituitary-gonadal axis and inhibiting testicular oxidative stress and apoptosis in rats.
Antioxidant properties of low-molecular-weight Ulva prolifera polysaccharides against H₂O₂-induced oxidative damage in BRL 3A cells and zebrafish.
Hippocampal GPR17 down regulation ameliorates CMS-induced depression-like behaviors in mice.
T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
DNA Methylation-Regulated FAM107A Affects Colorectal Carcinogenesis by Inhibiting FOXM1.
Identification of mitochondrial permeability transition-related gene signatures to predict lung adenocarcinoma survival and drug response.
An oral-gut microbial metabolite links Fusobacterium nucleatum to aggravated myocardial ischemia-reperfusion injury.
RFRP-3 suppresses ovarian granulosa cell function in Tan sheep via dual signaling pathways: PI3K/AKT/mTOR and MAPK/ERK1/2.
INHBB promotes liver metastasis of colorectal cancer via regulation of TGF-β/Smad signaling, EMT and anoikis resistance.
Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1/Nrf2/NF-κB pathway.
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling.
Integrated Network Pharmacology and Experimental Study on Shikonin-Induced Male Reproductive Toxicity.
Excessive fluoride induces renal cell apoptosis and subsequent renal dysfunction.
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Chrysophanol Attenuates Glucocorticoid-Induced Osteoporosis by Targeting the E74-Like Factor 5/Osteoglycin-Regulated PI3K/AKT/mTOR Signaling Axis: An In Vitro and In Vivo Study.
ELAVL1 interacts with APP and promotes Aβ-induced apoptosis in Alzheimer's disease by activating Bcl-2/Bax signaling.
Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair.
Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Urinary microbiome and metabolomic profiling reveal propionic acid as an enhancer of BCG immunotherapy in bladder cancer.
Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2/SIRT1/p53 signaling axis.
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Co-exposure to polystyrene nanoplastics and hexachlorocyclohexane induces enhanced human sperm toxicity in vitro.
The Herbal Pair Daphniphyllum calycinum-Polygonum hydropiper Alleviates Gastric Mucosal Injury via Regulating Autophagy and Targeting the TLR4/NF-κB/NLRP3 Pathway.
GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.
Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death.
Radiomodulatory and antioxidant properties of a novel pyrazine-linked quinazolinone sulfonamide derivative: Insights into renal apoptosis.
Novel transcription factor zinc finger 514 suppresses lung adenocarcinoma progression and enhances cisplatin sensitivity via transcriptional repression of COL1A1.
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction.
Selective Radioprotection by the Fusion Antioxidant Enzyme GS1XR Via an MMP-2/9-Cleavable Cell-Penetrating Switch.
Combining network pharmacology and experimental validation to study the action and mechanism of brusatol against lung adenocarcinoma.
Triple-Targeted Peptide-Photosensitizer-Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma.
Sugiol Alleviates Cerebral Ischemia/Reperfusion Injury in the Early Phase Involving the LRRK2/NF-κB Pathway.
Florfenicol impairs steroid hormone secretion in bovine ovarian granulosa cells: Involvement of the cAMP/PKA/StAR signaling pathway and oxidative stress.
Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
Zona pellucida is required for oocyte actin cortex and oocyte-somatic cell interactions during oocyte growth.
Liquiritin Enhances Chemosensitivity to Doxorubicin in Breast Cancer by Promoting Ubiquitination-Mediated Degradation of MCL1.
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Aberrant expression of TRIM26 suppresses ferroptosis through regulating GPX4 protein stability in colorectal cancer.
Mechanisms Contributing to Inhibition of Retinal Ganglion Cell Apoptosis by AMPK in Experimental Glaucoma.
Targeting VDAC1-dependent mtDNA release attenuates fibroblast innate immune activation and vitiligo pathogenesis.
Methylation of tenascin XB mediated by methyltransferase-like 3 can effectively suppress neural injury and cellular apoptosis induced by ischemic stroke.
Phenethyl Isothiocyanate Suppresses Hepatocellular Carcinoma Progression and Immune Evasion via ZNF652 Regulation of PD-L1.
USP2 Attenuates Spermatogenic Cell Apoptosis Via PINK1/Parkin-Dependent Mitophagy in Varicocoele: A Functional Study.
Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway.
Inhibition of mitochondrial RNA polymerase sensitizes cancer cells to radiation by inhibiting mitochondrial respiration.
BFGF downregulates endoplasmic reticulum stress to alleviate HUVEC cell damage under high-glucose and inflammatory conditions.
FR429 from Polygonum capitatum Demonstrates Potential as an Anti-hepatic Injury Agent by Modulating PI3K/Akt Signaling Pathway.
Effects of borneol on apoptosis of hypoxia/reoxygenation H9c2 cells and myocardial ischemia-reperfusion injury rats.
ZMIZ2/MCM3 Axis Participates in Triple-Negative Breast Cancer Progression.
ERRγ Promotes Multiple Myeloma Survival by Coordinating NF-κB Signaling and Mitochondrial Apoptosis Regulation.
Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression.
NLR Risk Score for Predicting Patient Prognosis in Hepatocellular Carcinoma and Identification of Oncogenic Role of NLRP5 in Hepatocellular Carcinoma.
Qizhi Kebitong Formula Ameliorates Sciatic Nerve Injury in Streptozocin-induced Diabetic Mice through PERK/ATF4/CHOP Endoplasmic Reticulum Stress Signaling Pathway.
Effect of anemoside B4 on ameliorating cerebral ischemic/reperfusion injury.
Inhibition of autophagy promotes ultrasound‑targeted microbubble destruction-induced apoptosis of pancreatic cancer cells.
Downregulation of lncRNA MNX1-AS1 promotes the ferroptosis and apoptosis of non-small cell lung cancer.
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Transcriptional enhanced associate domain factor 1 regulates cortactin-binding protein 2 N-terminal-like to control cell apoptosis in thyroid cancer.
Ailanthone inhibits bladder cancer tumor and cell proliferation, epithelial-mesenchymal transition, and activation of the Janus kinase/signal transducer and activator of transcription 3 signaling pathway.
BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2.
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.
Youthful systemic milieu in younger recipients alleviates acute kidney injury via attenuating apoptosis and oxidative stress in a rat kidney transplantation model.
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration.
Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions.
Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis.
Enhancement of YTHDF2 plays a protective role in acute IRI models through downregulation of TUG1 expression.
Oncosis is the predominant type of cell death in rhabdomyolysis following exertional heat stroke.
Exosomes from bone marrow mesenchymal stem cells protect melanocytes under vitiligo-related conditions through induction of NRF2/HO1 expression.
Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells.
Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells.
Lymph Node Exosomes Delivery Attenuates Myocardial Ischemia-Reperfusion Injury via Regulating PTEN-PI3K/Akt Pathway Mediated Myocardiocyte Apoptosis.
Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer.
MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway.
6-Hydroxygenistein Ameliorates High Altitude Brain Injury via Activating PI3K/AKT Signaling Pathway Based on Transcriptomic Analysis and Experimental Validation.
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study.
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity.
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Saikosaponin A Mediates the Anti-Acute Myeloid Leukemia Effect via the P-JNK Signaling Pathway Induced by Endoplasmic Reticulum Stress.
Platycodin D Enhances Glioma Sensitivity to Temozolomide by Inhibition of the Wnt/β-Catenin Pathway.
A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression.
GPR120/FFAR4 protects retinal vascular endothelial cells against high glucose injury via suppressing ROS-ERS mediated apoptosis.
Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury.
Protective Effects of Irisin Against LPS-Induced Intestinal Injury and Its Influence on Gut Microbiota in Septic Mice.
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Qijie Xiaopi Decoction Attenuates Gastric Mucosal Injury in PLGC Rats by Inducing Autophagy and Apoptosis Through PI3K/AKT/mTOR Pathway Inhibition.
Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis.
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Disulfidptosis-Associated CCNB2: A Prognostic Biomarker and Immune Microenvironment Modulator in Prostate Cancer.
Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.
Berberine-taxifolin co-administration attenuates inflammatory response and intestinal barrier injury via nf-κB/NLRP3 suppression in colitis.
Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis.
Efferocytosis-associated genes serve as prognostic biomarkers for pancreatic ductal adenocarcinoma and identify P2RY6 as a therapeutic target.
Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments.
Multi-omics analysis elucidates the therapeutic mechanisms of the Quzhi formula in metabolic dysfunction-associated steatohepatitis targeting gut microbiota, lipid metabolism, and the role of its metabolite fraxin.
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.
Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation.
Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation.
Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation.
Integrating bioinformatics and molecular experiments to reveal the critical role of the cellular energy metabolism-related marker PLA2G1B in COPD epithelial cells.
Wuzi-Yanzong-Wan inhibits testicular mitochondrial apoptosis in rats by downregulating TAp73-Mediated P38 MAPK-ADAM17 pathway.
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Modulation of the lncRNA TCONS_00265853-miR-421-5p-CLOCK axis by Ziyin Buyang Formula in polycystic ovarian syndrome with circadian rhythm disruption: an integrated bioinformatics and experimental approach.
Loss of DJ-1 alleviates microglia-mediated neuroinflammation in Parkinson's disease via autophagy-lysosomal degradation of NLRP3.
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Cilostazol-inhibited RhoA/NF-κB signaling mitigates hippocampal inflammation and post-stroke depression.
Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.
The protective effect of Blautia coccoides in secondary injury of intracerebral hemorrhage.
Pretreatment with Astragalus polysaccharide alleviates heat stroke-induced intestinal injury in mice.
Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.
Jiannao Pills alleviate depression-like behavior in chronic unpredictable mild stress-induced mice through NF-κB/NLRP3 pathway.
Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway.
The function of CD164 in breast cancer and its possibility as a molecular biomarker: bioinformatics analysis and experimental validation.
IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.
Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly.
Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice.
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.
Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition.
Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma.
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer.
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway.
Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways.
Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.
Genipin attenuates oxidative damage in periodontal tissues by alleviating mitochondrial dysfunction and abnormal glucose uptake through inhibition of UCP2.
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway.
CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis.
HOXB7 drives bladder cancer progression via H-Ras/ERK signaling: a potential therapeutic target and prognostic biomarker.
SATB2 promotes radiation resistance of esophageal squamous cell carcinoma by regulating epithelial-to-mesenchymal transition via the Wnt/β-catenin pathway.
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
NCYM facilitates cell proliferation and invasion in Wilms tumor by regulating SIX1/β-catenin axis.
BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.
Fibroblast growth factor 19 regulates polycystic ovary syndrome progression via FGFR4-ERK-NRF2 pathway.
Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic-reperfusion injury by targeting the NOX2/AMPK pathway.
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome.
Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage.
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Exploring the role of febuxostat's drug target XOR in erectile dysfunction: insights from human genetics and rat models.
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Effects of all-trans retinoic acid and oxygen concentration on the proliferation and differentiation of subcutaneous adipocytes in yak.
Knockdown of annexin A2 enhances the host cell apoptosis induced by Eimeria tenella.
Effect of transport stress on apoptosis and autophagy in goat lung cells.
Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.
SNORA33 Promotes Clear Cell Renal Cell Carcinoma Development and Resistance to Sunitinib Through Triggering the JAK/STAT Pathway.
3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis.
Human Neural Progenitor Cell-Derived Exosomes Deliver miR- 100 - 5p Targeting NOX4 mRNA to Alleviate Oxidative Stress in Acute Ischemia Injury.
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1.
Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF-κB Signaling Pathway.
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Bacterial cellulose membrane integrating phase-transited lysozyme nanofilm loaded with biguanides for dressing treatment of atopic dermatitis.
Integrative spatial multi-omics identifies the TEK receptor tyrosine kinase as a central biomacromolecule of endothelial-immune interactions in glioblastoma.
Regulation of macrophage phenotypes via NF-κB/NLRP3 and HIF1α/p53 pathways by fuco-galactoglucan from Agrocybe aegerita.
Modeling Mycobacterium tuberculosis pathogenesis in lung epithelial organoids reveals strain-specific host responses and intercellular crosstalk.
Imipramine Inhibits Osteosarcoma Invasion via Src Inactivation and Caspase-Dependent Apoptosis.
LncRNA H19 and miR-138 modulate retinal neovascularization and associated pathological features in hypoxia-induced disease models.
The m6A transferase METTL3 regulates high glucose-induced proliferation and apoptosis of human lens epithelial cells through the lncRNA TUG1/KHSRP/p38MAPK signaling axis.
Inhibition of USP5 Attenuates Atherosclerosis by Suppressing PDCD4-Mediated Endothelial Dysfunction: Evidence from In Vitro HUVEC and In Vivo Models.
The Age-Associated Long Noncoding RNA lnc81 Regulates Ovarian Granulosa Cell Proliferation and Apoptosis Through TEAD2-CCN1/2 Pathway in Mice.
Mst1 inhibition mitigates steroid-induced femoral head osteonecrosis by modulating autophagy in bone microvascular endothelial cells.
Benserazide‑mediated targeting hexokinase 2 enhances the cytotoxicity of cisplatin in non-small cell lung cancer cell models.
Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI.
Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS).
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling.
Synergistic mechanisms of Banxia Xiexin decoction in overcoming chemoresistance and enhancing chemosensitivity in colorectal cancer.
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice.
Synthesis and biological evaluation of diosgenin derivatives as potential anti-breast cancer agents.
Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro.
Shoutai pill exhibits anti-miscarriage efficacy through tripartite modulation of gut microbiota, systemic metabolism, and maternal-fetal immunity: A multi-omics analysis.
Ershiwuwei Shanhu pills alleviates cerebral ischemia injury in rats by regulating endoplasmic reticulum stress through GRP78/XBP1/CHOP pathway.
DAPK1 induces motor neuron apoptosis in hSOD1(G93A)-linked amyotrophic lateral sclerosis via regulating the Xiap/JNK pathway.
Protective Effects of Ganoderma Triterpenoids Supplementation Against Myocardial Injury in Exhaustion Exercise Mice via Regulation of the Keap1/Nrf2/HO-1 Pathway.
Knocking Down SKA1 Inhibits Hepatocellular Carcinoma Progression via Apoptosis: Integrating Single-Cell Transcriptomics With In Vivo and In Vitro Validation.
Protective effects of Ginkgolide B on myocardial ischemia reperfusion injury: role of the GAS6/Axl signaling pathway.
LncRNA LOXL1-AS1 promotes ovarian cancer progression by enhanced BRIP1 mRNA stability.
Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H(2)O(2)-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.
CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway.
Neochlorogenic acid inhibits gastric cancer cell growth through apoptosis and cell cycle arrest.
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease.
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Mechanisms of Saposhnikovia divaricata in attenuating NaAsO(2)-induced neural injury via the PI3K/AKT pathway.
Self-Assembling Amphiphilic Peptides Target the VDAC1-Hexokinase-II Complex to Induce Apoptosis in Cervical Carcinoma Cells.
Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Xuebijing alleviates sepsis-induced acute lung injury by inhibiting alveolar epithelial cell apoptosis via cAMP/PKA signaling pathway.
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Epalrestat, an aldose reductase inhibitor, mitigates doxorubicin-induced cardiotoxicity by inhibiting glycometabolism.
7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway.
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis.
Curcumin Inhibits Protease Activated Receptor 2-Induced ERK Phosphorylation Calcium Mobilization and Anti-Apoptotic Signaling in Inflammation-Driven Colorectal Cancer Cells.
Molecular engineering strategies for fabricating type-I mitochondria-targeted aggregation-induced emission photosensitizers for apoptosis-ferroptosis synergistically boosting photodynamic therapy.
Gremlin 1 regulates granulosa cell apoptosis through the TGF-β/SMAD signaling pathway during bovine follicular atresia.
Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.
MSTRG.118323.5 targets BAG5 as a miR-200-y sponge to regulate Sertoli cells apoptosis via PI3K/AKT/mTOR pathways of Bactrian camels.
Evodiamine protects against cardiac remodeling in heart failure through modulation of calcium signaling and CD47.
Polyethylene terephthalate (PET) microplastics induced male reproductive toxicity in mice by activating the p38-MAPK pathway.
Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca(2 +) ]i stability.
PADI1 aggravates endoplasmic reticulum stress in trophoblast cells by inhibiting the FAK-ERK signaling pathway.
Dectin-1 Drives Diabetic Retinopathy via Inducing Microglia-Mediated Inflammation and Blood-Retinal Barrier Breakdown.
Sargentodoxa cuneata suppresses lung adenocarcinoma progression by enhancing cytotoxic CD8(+) T activity through the ACY1/ARG2 interaction.
POM121 induces chemoresistance toward cisplatin in non-small cell lung cancer.
Glycyrrhizic Acid Inhibits Hippocampal Neuron Apoptosis by Activating the PI3K/ AKT Signaling Pathway.
Exercise Training Promotes Neural Remodeling and Vascular Regeneration in Cerebral Ischemic Rats Through the JNK/c-jun Signaling Pathway.
Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.
Early cardioprotective effects of SGLT2i on hypertensive cardiac remodeling via STIM1/Orai1-dependent calcium signaling: beyond blood pressure control.
Chlorogenic Acid Improves Salicylic Acid-Induced Cochlear Injury by Reducing Oxidative Stress and Inflammatory Response Through TLR4/NF-κB Signalling Pathway.
Ribociclib derivative Rib-CA suppresses breast cancer progression via p53-dependent apoptosis.
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
OTUD1 deficiency attenuates myocardial ischemia/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation.
Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation.
miR-140-3p Alleviates Pulmonary Arterial Smooth Muscle Cell Dysfunction via MAP2K6/p38 Pathway.
Cinobufagin induced myocardial cell toxicity in H9c2 cells via inhibiting histone methyltransferase SMYD1 expression.
Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model.
Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression.
Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration.
Quercetin induces immunogenic cell death against gastric cancer by targeting NR3C1.
Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system.
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis.
Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Hecogenin‑nitrogen mustard hybrids with improved anti-breast cancer activity: Design, synthesis, and biological evaluation.
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Dihydrocapsaicin attenuates oxidative stress and apoptosis in acute myocardial infarction via promoting Raf-1/ASK1 complex formation.
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Silibinin attenuates 3-nitropropionic acid-induced ovarian toxicity by alleviating oxidative stress and granulosa cell apoptosis.
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano-Fe(3)O(4) in spermatogonial GC-1 cells.
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.
Radioprotective Efficacy of Jujube Aqueous Extract and Arbutin: Synergistic Antioxidant and Anti-Apoptotic Mechanisms in Radiation Injury.
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
(-)-Epigallocatechin Gallate Ameliorates Chronic Stress-Induced Depression-Like Behavior in Rats by Inhibiting the NF-κB/Caspase-1 Signaling Pathway and Reducing IL-1β and IL-18 Expression.
Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation.
BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.
Arbutin improves lung injury in chicks induced by Mycoplasma gallisepticum infection.
Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis.
Transcriptomic Investigation of FoxM1-Mediated Neuroprotection by hAEC-Derived Exosomes in an In Vitro Ischemic Stroke Model.
Eimeria tenella AMA1 regulates host cell apoptosis through the mitochondrial pathway and the death receptor pathway.
Development of a CD9-Targeted Radiopharmaceutical for Imaging and Radionuclide Therapy in CD9-Positive Glioma.
Anti-ovarian cancer effects of forsythiaside A: insights from in vitro and in vivo studies.
Reversal of Myofibroblast Apoptosis Resistance and Collagen Deposition by Phaseoloidin-Induced Autophagy Attenuates Pulmonary Fibrosis.
Tanshinone IIA inhibits heat-induced growth of p53-mutant Huh-7 hepatocellular carcinoma by modulating osmotic homeostasis and glycolysis through targeting ALDH7A1.
Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway.
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
3-n-butylphthalide improves cerebral ischemia/reperfusion injury by regulating neuronal mitochondrial biogenesis via AMPK/PGC-1α signaling pathway.
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Mesenchymal stem cells inhibit mitochondrial fission by upregulating armadillo repeat containing 1, ameliorating oxidative stress in renal fibrosis.
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Fecal microbiota transplantation alleviated heat-induced colonic tissue damage, epithelial apoptosis, and oxidative stress.
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.
Cephalomannine as in vitro and in vivo anticancer agent in mesothelioma cells: mechanisms of action.
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Stigmasterol improves diabetic retinopathy by inhibiting VAMP7-mediated autophagy/mitophagy.
TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.
CDK11 Promotes Paclitaxel Resistance in Cervical Cancer by Regulating LATS1-Mediated Hippo Signaling Pathway Through Phosphorylation of NF2.
PTEN-L dephosphorylates Parkin and Ub Ser65 to aggravate mitophagy dysfunction in prion disease cell models.
Structural elucidation of an unusual acid heteropolysaccharide with moieties of glucuronogalactoarabinan and glucuronoarabinogalactan from young shoots of Aralia elata (Miq.) Seem.
Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.
Nitrite and microcystins co-exposure triggers PINK1-mediated mitophagy in spermatogonia.
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Nephroprotective mechanism of Kunkui Baoshen decoction in diabetic kidney disease: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway.
Isorhynchophylline alleviates preeclampsia via PI3K/AKT/mTOR-mediated trophoblast oxidative stress inhibition.
EGR1 Mediates Riluzole-Induced Apoptosis in Osteosarcoma via the Yap/p73-Bax Signaling Axis.
Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice.
Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy.
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy.
Long noncoding RNA ENST00000458139 promotes mitochondrial dysfunction and apoptosis of podocytes in diabetic kidney disease through binding with SNRPA1.
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Mangiferin targets PFKFB3 to inhibit glioblastoma progression by suppressing glycolysis and PI3K/AKT/mTOR signaling.
Inhibition of DYRK1A can alleviate MPTP/MPP(+)-induced neuronal apoptosis and mitochondrial damage.
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
BFGF alleviates diabetic endothelial dysfunction by downregulating Endoplasmic reticulum stress.
Exosomal gene signature in esophageal carcinoma: Insights from single-cell and bulk RNA sequencing.
Endoplasmic Reticulum Stress Is Involved in Prostaglandin F2α-Induced Goat Luteal Cell Apoptosis via the IRE1 Pathway.
Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis.
Caulerpin suppresses tumor-associated angiogenesis and tumor growth via Hippo signaling in cervical cancer.
Expression Patterns of Deubiquitinating Enzymes in Paclitaxel-Treated Lung Cancer Cells.
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Bone morphogenetic protein 1 as a macromolecular pan-cancer biomarker modulating the immune microenvironment and malignant phenotypes in glioblastoma.
Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia.
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.
PPM1G promotes chemoresistance in triple negative breast cancer by enhancing YAP signaling.
Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.
Protective Effect of Vinegar Powder on (60)Coγ Radiation-Injured Mice and Its Potential Mechanism.
DST-3, a novel cryptotanshinone derivate, attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation.
Calcitriol/Vitamin D receptor ameliorates fructose-induced enteritis-hepatitis axis dysregulation in mice.
SIRT3 deficiency aggravates mitochondrial metabolic disorder and podocyte injury in DKD via MPC2 acetylation.
PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis.
Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke.
Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia-Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling-Mediated Neutrophil Extracellular Traps Formation.
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.
Hypoglycemic effect and the post-treatment benefits of carrot pulp fermented by Lactobacillus casei NCU215 in type 2 diabetic mice: insights from gut microbiota regulation and restoration of pancreatic islet function.
Dietary supplementation with selenium yeast mitigates diquat-induced oxidative damage in oviductal magnum of hens.
The impact of STAiR18 on multiple myeloma survival rates.
Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis.
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Neuroprotective effects of hyperbaric oxygen therapy on vascular cognitive impairment in hypoperfused mice via miR-137-3p/TRAF3 pathway.
REDD1 Affects Proliferation, Apoptosis, Migration, and Colony Formation via p-ERK and p-JNK Signaling in Lung Adenocarcinoma Cells Under Hypoxia.
H(2)S-Activated Theranostic Platform for Precise Photoablation of Colorectal Tumors with NIR-II Dual-Modal Phototherapy.
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.
Panax notoginseng saponins suppress the PI3K/AKT pathway to enhance autophagy and apoptosis in pulmonary fibrosis.
ADRA2A contributes to airway inflammation and apoptosis in asthma through the ERK signaling in vitro and in vivo.
Exercise-derived peptide confers protection against septic cardiomyopathy by enhancing CCAAT/enhancer binding protein β-mediated autophagy.
Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites.
Saponins from Dioscorea nipponinca Makino rehabilitate UVB-induced skin photoaging by inhibiting oxidative stress and apoptosis via targeting STAT3.
Jianpi Huayu decoction exerts antitumor effects in pancreatic cancer via SCD1-mediated lipid metabolism remodeling/ferroptosis axis.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Glycyrrhetinic acid orchestrates ERS-pyroptosis crosstalk to elicit immunogenic cell death in hepatocellular carcinoma.
Gastrodin Injection Relieves Hypoxic-Ischemic Brain Injury in Newborn Rats by Regulating the P62/Nrf2/HO-1 Pathway.
hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability.
Trofinetide Improves Cognitive Function in APP/PS1 Mice by Suppressing Inflammation and Apoptosis.
Human OPN-derived peptide SV prevents BPD model through interacting with KIF5B to repair mitochondrial damage and inhibit apoptosis.
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer.
Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway.
Silibinin mitigates AKI-to-CKD transition via MAPK and PI3K/AKT signaling pathways in Ischemia-Reperfusion injury.
Influenza a(H1N1) virus infection impairs syncytiotrophoblast functions by promoting ferroptosis through the TNF-α/ISG15/EGR1 axis.
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Monotropein alleviates sepsis-associated encephalopathy by targeting matrix metalloproteinase-9.
CDC5L facilitates cardiomyocyte proliferation and ameliorates myocardial ischemia-reperfusion injury via modulation of the FGF10-YAP axis.
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis.
Single-atom Ca nanozyme induces glioma death through Ca(2+)-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment.
Mechanism of the traditional Chinese medicine SMBJ alleviates diabetes mellitus-induced Leydig cell dysfunction in rats testes.
GABA treatment promoting cell apoptosis in meningioma correlates with EGFR/BCL-2/BAX axis.
Optimization strategies for reversible myocardial injury caused by ultrasonic cavitation effects using an orthogonal experimental design.
Targeting the p38/MAPK pathway to induce apoptosis: a multidimensional mechanistic exploration of Mentha and its active compound diosmetin against liver cancer.
WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.
Wuling San ameliorates cerebral ischemia-reperfusion injury via suppression of the TRPM2/NLRP3 pathway.
Precision hyperthermia-induced HSP20 inhibits gastric cancer cell invasion, migration, and proliferation.
Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury.
Phytosphingosine suppresses gastric cancer through SFRP4/β-catenin axis-mediated Wnt signaling pathway inhibition.
Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study.
The antitumor effects and apoptotic mechanism of 20(S)-Protopanaxadiol in acute myeloid leukemia.
eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53.
Daidzein Attenuates Cadmium-Induced Neurotoxicity via Inhibiting Apoptosis and Mitophagy in the Cerebral Cortex of Sprague-Dawley Rats.
Menstrual Blood-Derived Endometrial Stem Cells Ameliorate Ovarian Senescence by Relieving Oxidative Stress-Induced Inflammation.
Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Host genetic variation governs PCV2 susceptibility through CXCL13 and ELK1-mediated immune regulation.
Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy.
Investigating the molecular mechanism of purslane‑based vitiligo treatment using network pharmacology, molecular docking and in vitro analyses.
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer.
Targeting mRNA export complex macromolecules THO subunits (Thoc2 and Thoc5) for somatic cell reprograming.
A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep.
HKDC1 promotes colorectal cancer progression by regulating RCOR1 expression to activate the Wnt/β-catenin pathway, enhancing proliferation, migration, and epithelial-mesenchymal transition.
PDZK1 regulated by miR-145-5p protects against endothelial cell apoptosis and diabetic retinopathy by targeting mitochondrial function.
Five racemic phthalides from the aerial parts of Lycopodiastrum casuarinoides and their neuroprotective activities.
Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway.
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
EPIC-1042 alleviates cerebral ischemic/reperfusion injury through TAX1BP1-induced mitophagy.
Formosanin C inhibits triple-negative breast cancer progression by suppressing the phosphorylation of STAT3 and the polarization of M2 macrophages.
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice.
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome.
Mg(2+)-Loaded Black Phosphorus Nanosheet Protects against Cerebral Ischemic Injury through Anti-Oxidative and Anti-Inflammatory Effects.
Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway.
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Study on the effects and mechanism of RRM2 on three gynecological malignancies.
LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese.
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Rilmenidine attenuates intracerebral hemorrhage by regulating autophagy flux and apoptosis via the HO-1/Fe(2+)/ERK pathway.
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
Effect of periplocin on malignant behavior of oral squamous cell carcinoma cells.
GPR35 prevents drug-induced liver injury via the Gαs-cAMP-PKA axis in macrophages.
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Mechanistic Insights into T-2 Toxin-Induced Thymic Epithelial Cell Injury and Immunotoxicity via the ROS-NF-κB-NLRP3 Signaling Axis.
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.
Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer.
miRNA-1229-5p promotes migration and invasion and suppresses apoptosis of endometrial cells via the STMN1/p38 MAPK axis in endometriosis.
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.
Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.
Inflammation-responsive biomimetic nanoparticles with epigallocatechin-3-gallate for acute lung injury therapy via autophagy enhancement.
Polysaccharides from Dicliptera chinensis (L.) Juss. Attenuates drug-induced liver injury by phosphorylating AMPK and thus facilitating the entry of FOXO3 into the cell nucleus.
Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-κB and MAPK pathways.
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-κB.
Long noncoding RNA SNHG5 promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis.
Corynoxeine Supplementation Ameliorates Colistin-Induced Kidney Oxidative Stress and Inflammation in Mice.
Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages.
Phytochemical characterization and pharmacological mechanisms of Huazhuo Sanjie Chubi Decoction in treating gouty arthritis: A multivariant approach.
Integrating metabolomics and network pharmacology to investigate Mu Jin Powder prevents ethanol-induced gastric ulcer in rats.
Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia.
Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species.
Liraglutide Inhibits Autophagy to Ameliorate Post-Cardiac Arrest Brain Injury and Ferroptosis in Rats.
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.
Inhibition of microRNA-139-5p by glucagon-like peptide-1 ameliorates oxidative stress-induced vascular endothelial cell damage via targeting SOD1/GCLc.
Protective role of vitamin D receptor against mitochondrial calcium overload from PM(2.5)-Induced injury in renal tubular cells.
DANCR knockdown alleviates neuroinflammation and functional recovery after spinal cord injury via regulating the ACTN4 / STAT3 axis.
TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway.
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice.
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells.
Terazosin, a repurposed GPR119 agonist, ameliorates mitophagy and β-cell function in NAFPD by inhibiting MST1-Foxo3a signalling pathway.
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop.
Berberine Inhibits Migration and Apoptosis of Rat Podocytes in Diabetic Nephropathy via the Novel lncRNA LOC102549726 Related Pathway.
Pubescenoside D Ameliorates Myocardial Ischemia-Reperfusion Injury via Preventing the Dissociation of HK2 and Promoting Mitophagy by Targeting GSK-3β.
Mangiferin Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the GAS6/Axl Signaling Pathway.
Oleanolic acid improves the in vitro developmental competence of early porcine embryos by reducing oxidative stress and ameliorating mitochondrial function.
Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2.
NGR1 reduces neuronal apoptosis through regulation of ITGA11 following subarachnoid hemorrhage.
Mild hypothermia (35°C) reduces myocardial ischemia-reperfusion injury and attenuates hypoxia induced apoptosis of H9C2 cardiomyocytes by changing the phosphorylation level of Connexin43 (Cx43) protein.
MicroRNA-9-5p regulates apoptosis of human osteoarthritis chondrocytes through suppressing TnC.
Selenium triggers AMPK-mTOR pathway to modulate autophagy related to oxidative stress of sheep Leydig cells.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
DEF6 regulates renal ischemia reperfusion injury through suppressing the WWP2 mediated ubiquitination of PARP1.
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm.
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism.
Trojan Horse-Like Biohybrid Nanozyme for Ameliorating Liver Ischemia-Reperfusion Injury.
Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway.
SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.
Pelvic vasectomy and its protective effects on rat testis function.
AKR1C3 protects cardiomyocytes against hypoxia-induced cell apoptosis through the Nrf-2/NF-κB pathway.
Clemastine fumarate alleviates endoplasmic reticulum stress through the Nur77/GFPT2/CHOP pathway after ischemia/reperfusion in rat hearts.
Cornuside as a promising therapeutic agent for diabetic kidney disease: Targeting regulation of Ca(2+) disorder-mediated renal tubular epithelial cells apoptosis.
Impact of POU3F4 mutation on cochlear development and auditory function.
The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1.
C-reactive protein-induced injury in Mycoplasma pneumoniae-infected lung epithelial cells is mediated by the P38 MAPK/mitochondrial apoptosis pathway.
Single-Cell Sequencing Reveals the Heterogeneity of Hepatic Natural Killer Cells and Identifies the Cytotoxic Natural Killer Subset in Schistosomiasis Mice.
Probiotic nanovesicles encapsulating baicalin: a strategy to overcome colorectal cancer.
Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study.
N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway.
Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities.
Bio-SS-TS as a Targeted Antitumor Drug Exerts an Anti-Liver Cancer Effect by Enhancing Mitochondria-Dependent Apoptosis.
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis.
Berberine Exerts Neuroprotective Effects in Alzheimer's Disease by Switching Microglia M1/M2 Polarization Through PI3K-AKT Signaling.
Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.
MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells.
S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis.
MiR-222-3p loaded stem cell nanovesicles repair myocardial ischemia damage via inhibiting mitochondrial oxidative stress.
The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway.
The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.
Exercise preconditioning increases circulating exosome miR-124 expression and alleviates apoptosis in rats with cerebral ischemia-reperfusion injury.
LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Mechanism of Marsdenia tenacissima in treating breast cancer by targeting the MAPK signaling pathway: Utilising metabolomics, network pharmacology, and In vivo experiments for verification.
Dual-responsive stem cell microspheres modified with BDNF for enhanced neural repair in diabetic erectile dysfunction.
Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway.
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
LINC02154 Promotes Esophageal Squamous Cell Carcinoma Progression via the PI3K-AKT-mTOR Signaling Pathway by Interacting With IGF2BP2.
OSBP Participates in Neural Damage Repair by Regulating Lysosome Transport Under Oxidative Stress.
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Melatonin ameliorates PM2.5-induced airway inflammation and apoptosis by PERK/eIF2α/ATF4/CHOP in chronic obstructive pulmonary disease mice.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Madecassoside mitigates acute myocardial infarction injury by activating the PKCB/SPARC signaling pathway.
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Nab-Paclitaxel Promotes Radiosensitization by Inducing DNA Damage and Inhibiting Macrophage M2 Polarization in Cholangiocarcinoma.
Elucidating the anticancer potential of dendrobine in renal cell carcinoma treatment.
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Combined Ribociclib and NU7026 administration enhances radio-sensitivity by inhibiting DNA repair in prostate cancer.
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma.
Fe-curcumin nanozymes-mediated reactive oxygen species scavenging and anti-apoptotic effects on age-related cataracts.
Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects.
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.
Polygonatum cyrtonema polysaccharide alleviates dopaminergic neuron apoptosis in Parkinson's disease mouse model via inhibiting oxidative stress and endoplasmic reticulum stress.
Single-Cell RNA Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte-Neuron Interaction in Cognitive Decline After High-Altitude Cerebral Edema.
Potential of recombinant CAV1-Fc in the treatment of ApxI toxin-induced damage by Actinobacillus pleuropneumoniae.
Inhibition of SIRT1/HSF1 pathway contributes to doxorubicin-induced nephrotoxicity in ovarian tumor-bearing mice.
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
CCDC134 enhances ovarian reserve function and angiogenesis by directly interacting with INHA in a mouse model of premature ovarian insufficiency.
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis.
Tripterygium wilfordii polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner.
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate.
Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice.
Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1.
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2.
Curcumol Ameliorates Cisplatin-induced Nephrotoxicity by Targeting TAK1 and Inhibiting MAPK and NF-κB Pathways.
Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury.
Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway.
Hsp70 incompletely disaggregates misfolded K488X-menin to promote tumourigenesis in a family with multiple endocrine neoplasia type 1.
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons.
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Polypyrrole-ferric phosphate-methotrexate nanoparticles enhance apoptosis/ferroptosis of M1 macrophages via autophagy blockage for rheumatoid arthritis treatment.
Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria.
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.
Ergosterol Protects Canine MDCK Cells from Gentamicin-Induced Damage by Modulating Autophagy and Apoptosis.
GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer's disease.
Huangqi fuling decoction inhibits the invasion and metastasis of gastric cancer via the TNF signaling pathway.
Characterization of T cell proliferation-associated hepatocellular carcinoma subtypes, predictive signatures, and candidate targets.
TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.
Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.
Pharmacological Intervention with 4-Phenylbutyrate Ameliorates TiAl6V4 Nanoparticles-Induced Inflammatory Osteolysis by Promoting Macrophage Apoptosis.
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Chuanxiong-Danggui herb pair alleviated cognitive deficits of APP/PS1 mice by promoting mitophagy.
Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway.
Photothermal Hyperthermia Suppresses Liver Tumor Growth Via Hippo Signaling Pathway-Dependent Inhibition of Cell Proliferation and Induction of Apoptosis.
Human neural stem cell-derived small extracellular vesicles enhance functional recovery after ischemic stroke through the miR-362-3p/MCAM/Wnt/β-catenin axis.
Development of Theranostic (177)Lu-Labeled Polymeric Nanoparticles ((177)Lu-PNPs) for the Treatment of Head and Neck Cancer.
The miR-21-5p/DUSP8/MAPK signaling pathway mediates inflammation and apoptosis in vascular endothelial cells induced by intermittent hypoxia and contributes to the protective effects of N-acetylcysteine.
The development of pyridazinone-based andrographolide derivatives as anti-cancer agents with the ability of inhibiting the TFAP4/Wnt/β-catenin signaling pathway.
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
KLF4 mediates the contradictory effects of phenylethyl isothiocyanate in gastric cancer intervention.
PELI2 inhibits colorectal cancer development through MAPK signaling pathway.
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
A Carrier-Free Triple-Drug Co-Assembled Nanoformulation for Synergistic Treatment of Cerebral Ischemia-Reperfusion Injury.
Poly-lysine-modified recombinant protein nanocages for effective delivery of small activating RNA.
Molecular mechanism of rapamycin-induced autophagy activation to attenuate smoking-induced COPD.
Muscle-derived factor alleviated cognitive impairment caused by intestinal ischemia-reperfusion.
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
MiR-124 Delivered by Extracellular Vesicles from Mesenchymal Stem Cell Exerts Neuroprotective Effects by Stabilizing the p62-Keap1-Nrf2 Pathway after Spinal Cord Injury in Rats.
Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia.
Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11.
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response.
Metformin Improves Palmitate-Induced Follicular Granulosa Cell Dysfunction by Activating ULK1-Mediated Autophagy.
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.
Neutralization of IL-33 ameliorates septic myocardial injury through anti-inflammatory, anti-oxidative, and anti-apoptotic by regulating the NF-κB/STAT3/SOCS3 signaling pathway.
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro.
Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
CD11b Blockade Ameliorates Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil and Monocyte Infiltration.
ALA Alleviates Liver Damage in Septic Mice Through PI3K/AKT Signaling Pathway.
A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma.
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization.
Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α.
Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway.
Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule (CP) on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification.
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction.
HOXD13 knockdown attenuates apoptosis in prostate cancer via the upregulation of MDM2/p53 signaling.
Targeting Eg5 using Arry520 combats gastric cancer by inducing monopolar spindles.
Galangin Regulates Oxidative Stress Levels in Porcine Embryos Through Interaction with the Neh1 Domain of Nrf2.
Neferine induces cell growth inhibition and apoptosis via ROS-mediated activation of p38 in pancreatic ductal adenocarcinoma cells.
EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines.
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis.
miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis.
Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer.
Annexin A2: regulating glioma's fate and a potential therapeutic target.
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.
Gallic Acid and Taurine Attenuate Thiamethoxam-Induced Hepatotoxicity in Rats by Modulating SIRT-1/PGC-1α, NF-κB/iNOS, and p53/Bax/Caspase-3 Pathways.
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment.
Mechanistic exploration of Dahuang Zhechong Pill against hepatic fibrosis via integrated serum pharmacochemistry, UHPLC-ESI-QTOF-MS/MS, network pharmacology, and molecular docking with cellular and zebrafish validation.
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Heat stress affects expression levels of circadian clock gene Bmal1 and cyclins in rat thoracic aortic endothelial cells.
Non-invasive assessment of stem cell DNA integrity in response to environmental stressors.
A LINC00472-encoded polypeptide impedes migration and proliferation through modulation of the HDAC2/SP1 axis in non-small cell lung cancer cells.
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway.
MS275 Inhibits Neuroblastoma Cell Growth by Mediating H3K27ac/PROX1 Axis In Silico and In Vitro.
p-phenoxyphenol impaired male fertility by disrupting the testicular function and local microenvironment.
SIRT5 alleviates oxidative stress of boar sperm induced by cryopreservation through IDH2 and SOD2 pathway.
Organic cation transporter 3 on neuronal mitochondria mediates MPP(+)-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner.
Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.
Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death.
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Biomimetic cancer cell membrane engineered lipid nanoparticles for enhanced chemotherapy of homologous malignant tumor.
Hsa_circ_0016662 acts as a prognostic biomarker and promotes the progression of hepatocellular carcinoma via autophagy regulation.
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.
Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy.
Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Selective Activation of G Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage.
Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology.
Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora.
Irisin alters D-galactose-induced apoptosis by increasing caveolin-1 expression in C2C12 myoblasts and skeletal muscle fibroblasts.
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Gypenoside XLIX alleviates sepsis-associated encephalopathy by targeting PPAR-α.
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease.
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells.
Diagnostic and prognostic potential of FBXO8 expression in kidney renal clear cell carcinoma and its regulation of renal adenocarcinoma cells.
A novel protein encoded by circARHGAP12 attenuates DNA damage and apoptosis by regulating MDC1 in intestinal ischemia/reperfusion injury.
LINC00942 Alleviates NaAsO(2)-induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p.
Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity.
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Protective role of Yougui Yin in experimental knee osteoarthritis: From the perspective of macrophage polarization.
Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism.
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer.
Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Cyclovirobuxine D inhibits triple-negative breast cancer via YAP/TAZ suppression and activation of the FOXO3a/PINK1-Parkin pathway-induced mitophagy.
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats.
MFGE8 promotes gastric cancer progression by activating the IL-6/JAK/STAT3 signaling.
HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide.
Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway.
Anti-tumor Effects of Hedyotis diffusa Willd on Cervical Cancer: Inhibition of Proliferation, Migration, and Induction of Apoptosis.
ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress.
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
Vitamin A enhances PI3K/Akt signaling and mitigates enterocyte apoptosis in a mouse model of necrotizing enterocolitis.
CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway.
Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function.
hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1.
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Taraxasterol extracted from Ixeridium gramineum (Fisch.) Tzvel. Attenuated D-GalN/LPS-induced fulminant hepatitis by modulating the JAK/STAT and TNF signalling pathways.
Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.
Osteoking inhibits apoptosis of BMSCs in osteoporotic rats via PI3K/AKT signaling pathway.
Revealing the molecular mechanism of baohuoside I for the treatment of breast cancer based on network pharmacology and molecular docking.
Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota.
N(6)-methyladenosine in 28S rRNA promotes oncogenic mRNA translation and tyrosine catabolism.
Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome.
Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.
Icaritin alleviates motor impairment and osteoporosis in Parkinson's disease mice via the ER-PI3K/Akt pathway.
Integrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy.
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy.
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy.
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma.
DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a.
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development.
FHOD3 shows clinical significance in progression of ovarian cancer through regulation of caspase-3 signaling pathway.
Heat Tolerance-Associated circRNA3685 Regulates Apoptosis and Autophagy in Bovine Mammary Epithelial Cells via Sponging bta-miR-138.
Changes in meat quality of Esox Lucius during postmortem storage: Based on the lysosomal-mitochondrial apoptotic pathway.
Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer.
Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.
Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress.
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src.
Identification of Novel 58-5p and SREBF1 Interaction and Effects on Apoptosis of Ovine Ovarian Granulosa Cell.
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.
RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.
Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis.
SMP30 alleviates cerebral ischemia/reperfusion-induced neuronal injury by inhibiting HDAC4/PSD-95 to preserve mitochondrial function.
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
COPS5 regulates osteosarcoma progression by upregulating KHSRP to promote Per2 mRNA decay.
Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance.
Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression.
Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy.
Oxidative stress and apoptosis of the spinal cord in a rat model of retinoic acid-induced neural tube defects.
Omaveloxolone Ameliorates Cognitive Deficits by Inhibiting Apoptosis and Neuroinflammation in APP/PS1 Mice.
Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy.
METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway.
Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway.
Multi-omics analysis explore the mechanism of deoxynivalenol inhibiting rabbit appetite through microbial-gut-brain axis.
High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Geniposide Protects Against Myocardial Infarction Injury via the Restoration in Gut Microbiota and Gut-Brain Axis.
Selenium yeast alleviates diquat-induced oxidative stress and testicular damage in roosters.
oar-miR-411a-5p Promotes Proliferation and Differentiation in Hu Sheep Myoblasts Under Heat Stress by Targeting SMAD2.
Aβ -induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases.
E3 ubiquitin ligase ITCH-mediated proteasomal degradation of WBP2 sensitizes breast cancer cells to chemotherapy through restraining AMOTL2/c-JUN axis.
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke.
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway.
Insulin-like growth factor-1 promotes the testicular sperm production by improving germ cell survival and proliferation in high-fat diet-treated male mice.
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors.
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis.
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8(+) T-cell antitumor activity via the non-canonical P53/STING pathway.
Experimental study on the inhibitory effect of Halofuginone on NSCLC.
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma.
Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.
Discovery of Novel Aromatic Urea-Imidazole Salt Derivatives for Cancer Therapy via Targeting ERK1/2.
Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer.
Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity.
Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress.
Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
The Natural Antherea pernyi Sericin Protein Suppresses Gastric Cancer Formation by Inhibiting Cell Proliferation and Inducing Cell Apoptosis.
Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer.
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10.
Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis.
Mogroside V ameliorates astrocyte inflammation induced by cerebral ischemia through suppressing TLR4/TRADD pathway.
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
Efficient Photosensitizer Delivery by Neutrophils for Targeted Photodynamic Therapy of Glioblastoma.
Tributyl Phosphate Induced Male Reproductive Toxicity in Mice.
Low-intensity pulsed ultrasound promotes proliferation and differentiation of neural stem cells to enhance spinal cord injury recovery.
Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.
PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development.
Estrogen Promotes Endometrial Cancer Development by Modulating ZNF626, SLK, and RFWD3 Gene Expression and Inducing Immune Inflammatory Changes.
CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury.
Intranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R/GRP75/VDAC1 on MAMs.
MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells.
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
A novel 5'tRNA-derived fragment tRF-Tyr inhibits tumor progression by targeting hnRNPD in gastric cancer.
Periplaneta americana Extract Protects Glutamate-Induced Nerve Cell Damage by Inhibiting N-Methyl-D-Aspartate Receptor Activation.
Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
Inhibition Effects and Mechanism Study of rAj-HRP30, a Recombinant Histidine-Rich Peptide from Apostichopus japonicus, on the Viability of Pancreatic Ductal Adenocarcinoma Cells Panc01 and Panc02.
Methylase METTL3 regulates oxidative stress-induced osteoblast apoptosis through Wnt/β-catenin signaling pathway.
Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.
Raddeanin A suppresses intracellular (5)Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma.
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice.
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
RhFGF21 protected PC12 cells against mitochondrial apoptosis triggered by H(2)O(2) via the AKT-mediated ROS signaling pathway.
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.
MAP6D1 Silencing alleviates high glucose-induced injury of trophoblast cells during gestational diabetes mellitus.
Comparative Evaluation of Biocompatibility between Conventional and Computer-Aided Design/Computer-Aided Manufacturing Dental Polymers Using a Golden Hamster Model.
Harmine derivative H-2-168 induces the death of Echinococcus granulosus by regulating mitochondrial fusion and fission.
Cancer-associated fibroblast-derived extracellular vesicles regulate lipophagy through PLIN2 to modulate dormancy in salivary gland adenoid cystic carcinoma cells.
Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8(+) T cells by granzyme B and perforin.
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Arfgef3 knockout ameliorates ischemia reperfusion-induced acute kidney injury via mitochondrial dysfunction alleviation in mice.
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.
TM4SF1 as a Prognostic Biomarker and Therapeutic Target in Cervical Cancer.
Design, synthesis, and bioevaluation of pyrazole-containing tubulin polymerisation inhibitors based on conformational constraint strategy.
Stemness reducible effects of glyasperin A against NCCIT teratocarcinomas.
Kirenol Ameliorates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation.
Study on the Stereoselective Pharmacokinetics and Neuroprotective Effects on HT22 Cells of Pinocembrin Enantiomers.
Enhanced oral nanomedicine utilizing biomineralized oncolytic virus for synergistic gastrointestinal cancer therapy.
Bovine tubulin cofactor D (TBCD) disrupts tubulin dimers and inhibits tumor growth via the TNF-α signaling pathways-mediated ROS production.
CD44 and αV-integrins dual-targeting bimetallic nanozymes for lung adenocarcinoma therapy via NIR-enhanced ferroptosis/apoptosis.
Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice.
Effect of hesperidin on nanocopper induced PANoptosis in chicken kidney through RIPK1/ZBP1 pathway.
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
ASIC1a Promotes nucleus pulposus derived stem cells apoptosis through modulation of SIRT3-dependent mitochondrial redox homeostasis in intervertebral disc degeneration.
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Therapeutic Effects of Phyllanthus urinaria L on Cisplatin-Induced Acute Kidney Injury: Anti-Inflammatory, Anti-Apoptotic, and Anti-Oxidative Action.
Polydatin's neuroprotective mechanism in optic nerve injury: targeting mitochondrial function and glial cell activation.
Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury.
Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis.
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Macrophage extracellular traps impair intestinal barrier function in DSS-induced colitis in mice by inducing intestinal epithelial cell apoptosis.
Juglone targets MMP-1 to inhibit gastric cancer progression.
Molecular insights into α-Lactalbumin-Chlorogenic acid interaction: Peptide design and anti-inflammatory mechanisms.
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway.
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2-mediated pathway.
Acyl-CoA dehydrogenase long chain acts as a tumor-suppressive factor in lung adenocarcinoma progression.
Appropriate doses of ionizing radiation facilitate the proliferation and anti-tumor effects of γδ T cells through ERK and p38MAPK pathways in vitro.
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice.
Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation.
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Design, synthesis, and evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as anti-HCC agents targeting Nur77.
YTHDC2 promotes sepsis-induced cardiomyopathy by activating apoptosis and NF-κB pathway.
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction.
Fibroblast-secreted ADAMTSL2 promotes cardiac repair after myocardial infarction by activating LRP6/β-catenin signaling.
YAP regulates the hypertrophy and apoptosis of antler chondrocytes through maintaining calcium homeostasis and mitochondrial function.
Puerarin alleviates liver injury induced by heat-stress through regulating oxidative stress and apoptosis in broilers.
MICU1 attenuates neuronal apoptosis after subarachnoid hemorrhage by inhibiting mitochondrial calcium overload and damage.
Skullcapflavone II Inhibits SLC1A4-Mediated L-Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer.
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Neuroprotective peptide OL-FS13 attenuates cardiac apoptosis and myocardial infarction injury through Nrf2/HO-1 pathway.
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux.
Albiflorin enhances the antitumor effects of propofol in hepatocellular carcinoma cells by inhibiting the Wnt/β-catenin signaling activation.
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism.
The Role of Chaf1b in Maintaining Glioma Stem Cell Stemness and Regulating Microglial Polarization.
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.
EXOSC3 knockdown induces G1/S phase arrest to suppress hepatocellular carcinoma cell proliferation.
Apigenin Alleviates Zearalenone-Induced Oxidative Stress and Apoptosis in Swine Testis Cells Through the Wnt Signaling Pathway.
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway.
Alkaloids isolated from Scutellaria Barbata D. Don trigger apoptosis and inhibit migration by modulating the p38-p53 pathway in ovarian cancer.
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
[Dietary secoisolariciresinol diglucoside alleviates chronic kidney disease in offspring rats caused by maternal trans-fatty acid exposure by regulating the Bcl-2/Bax/caspase-3 signaling axis].
Sodium butyrate attenuates sodium fluoride-induced cardiac injury in rats via modulating oxidative stress, inflammation, and apoptosis.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Long noncoding RNA BMPR1B-DT promotes anoikis and reduces proliferation in ovarian cancer.
ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer.
A Scorpion Peptide Exerts Selective Anti-Leukemia Effects Through Disrupting Cell Membranes and Triggering Bax/Bcl-2-Related Apoptosis Pathway.
CCL8 suppresses ovarian cancer progression via M1 macrophage polarization and NF-κB-mediated apoptosis.
Transcription factor EGR2 drives cataract formation through IGFBP3-mediated oxidative injury in lens epithelial cells.
Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy.
Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis.
Loss of the miR-221/222 Cluster Promotes the Pathogenesis of Osteoarthritis in Inflamed Mouse Chondrocytes and Osteoarthritis Models.
Resveratrol Derivatives with a Urea Backbone Exert Anticancer Effects against Liver Cancer via Apoptosis Induction and Metastasis Inhibition.
Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights.
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Liproxstatin-1 Protects SH-SY5Y Cells by Inhibiting H(2)O(2)-Induced Excessive Mitophagy and Apoptosis.
HIC2 suppresses glioblastoma progression via transcriptional repression of SEMA3A and inhibition of TGF-β signaling.
Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel.
Apelin-13/APJ promotes neural stem cells to repair ischemic stroke.
The Synergic Inhibition of Wilforlide A With Cisplatin in Lung Cancer Is Mediated Through Caspase-3 and NFκB Signaling.
Mechanism of lncRNA WARS2-IT1 promoting angiogenesis of glioma through miR-299-3P/VEGFA axis and activating PI3K/AKT signaling pathway.
Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury.
cPDS Promotes Cell Apoptosis by Reducing the Translational Efficiency of BIRC3 mRNA in HCC.
GPR30 Inhibits Neuronal Apoptosis After Subarachnoid Hemorrhage by Activating the Wnt/β-Catenin Pathway in a m6A-dependent Manner.
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
5-Methoxytryptophan improves cerebrovascular injury induced by chronic kidney disease through NF-κB pathway.
Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells.
USP39 Depletion Plays Repressive Roles in Laryngeal Squamous Cell Carcinoma Development.
Andrographolide Attenuates Myocardial Ischemia-Reperfusion Injury in Mice by Up-Regulating PPAR-α.
Inhibition of FKBP5 Alleviates Inflammation and Intestinal Barrier Dysfunction in Sepsis.
P5CS deacetylation mediated by SIRT2 facilitates tumor growth by enhancing mitochondrial respiration in hepatocellular carcinoma.
Investigation of the Protective Effect of Red-Light-Intervened Dendrobium officinale on Rats With Gastric Injury Based on Serum Metabolomics.
Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression.
Dissolvable microneedle-assisted transdermal administration of diacerein nanoparticles achieved satisfactory therapeutic effects in tendon-bone insertion repair by reducing oxidative stress and inflammation.
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein.
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF-κB/COX-2 Signalling Pathways.
TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons.
l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids.
Methyl alcohol extract of marine green alga Enteromorpha linza (Linnaeus) J. Agardh. induces reactive oxygen species-dependent growth arrest and apoptosis in human hepatocellular carcinoma Hep3B cells.
ARHGAP11A is a potential prognostic biomarker and therapeutic target for pancreatic adenocarcinoma.
Dehydroabietic acid protects against cerebral ischaemia-reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ.
Mechanism of sulforaphane in treatment of pancreatic cancer cell based on network pharmacology and in vitro experiments.
Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis.
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging.
Guggulsterone suppresses osteosarcoma progression by inhibiting glycolysis through MAPK signaling pathway.
Diminution of HSP75 disrupts intestinal epithelial barrier by inciting mPTP opening in ulcerative colitis.
Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts.
CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.
Melatonin mitigates arsenic and fluoride-induced cardiotoxicity in chickens by maintaining mitochondrial homeostasis.
Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma.
Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway.
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.
FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization.
Mechanistic insights into the anti-tumor effects of neochlorogenic acid in hepatocellular carcinoma: in vitro and in vivo studies.
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice.
Integrated network pharmacology and metabolomics to explore the mechanism of Kadsura coccinea root in alleviating acetaminophen-induced liver injury.
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
HIF-1α protects cigarette-induced airway epithelial cell apoptosis in COPD by activating REDD1.
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Pacific Oyster-Derived Alcohol Dehydrogenase Activating Peptide Leu-Gln-Pro-Pro-Arg Ameliorates Alcoholic Liver Disease by Enhancing Alcohol Metabolism and Suppressing Mitochondrial-Mediated Apoptosis.
TGF-β-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation.
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.
PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models.
SIRT3 Acetylation Regulates Mitophagy to Alleviate Deoxynivalenol-Induced Apoptosis in Porcine Alveolar Macrophages Cells.
Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy.
Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications.
Oxypalmatine promotes apoptosis and protective autophagy in lung cancer cells via the PI3K/AKT pathway.
Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment.
Mitochondrial-dependent apoptosis and STAT3 activation induced by oxidative stress in pemphigus vulgaris.
PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy.
Mechanisms of Differential Sensitivity to Ethanol-Induced Apoptosis in Mouse Spinal Cord at Different Developmental Stages-Akt/GSK Signaling and BAX.
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib.
Yishen Tongluo formula ameliorates kidney injury modulating inflammation and apoptosis in streptozotocin-induced diabetic kidney disease mice.
Low molecular weight heparins promote migration and invasion of trophoblast cells through regulating the PI3K/AKT signaling pathway.
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy.
Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma.
Oxidized Low-Density Lipoprotein Decreases the Survival of Bone Marrow Stem Cells via Inhibition of Bcl-2 Expression.
Plasma-Derived Exosomal i-tRF-LeuCAA as Biomarker for Glioma Diagnosis and Promoter of Epithelial-Mesenchymal Transition via TPM4 Regulation.
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury.
Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair.
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia.
Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: in vitro insights and in silico modelling of proapoptotic gene product-compound interactions.
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein.
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists.
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Xin-Ji-Er-Kang balances mitochondrial fusion and fission to protect cardiomyocytes in mice with heart failure by regulating the ERα/SIRT3 pathway.
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis.
HUWE1-Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury.
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway.
MIS18BP1 promotes bladder cancer cell proliferation and growth via inactivating P53 signaling pathway.
Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2.
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer.
Targeted Regulation of HSP70 by the ARP2/3 Complex in Mammary Epithelial Cells and Its Impact on Host Cell Apoptosis.
SO(2) derivatives impair ovarian function by inhibiting Serpine1/NF-κB pathway-mediated ovarian granulosa cell survival.
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Zearalenone Depresses Lactation Capacity Through the ROS-Mediated PI3K/AKT Pathway.
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting.
UFBP1 Ameliorates Heat Stress-Induced Apoptosis via Mitochondria-Mediated Pathway in Bovine Mammary Epithelial Cells.
Sulforaphane Inhibits LPS-induced Macrophage PANoptosis via TLR4/NFκB Pathway: A Potential Therapeutic Strategy for Acute Lung Injury.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage.
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation.
HPV11E6/E7 induces nasal epithelial hyperplasia through JAK2/STAT3 signaling pathway.
Lactobacillus murinus ZNL-13 Modulates Intestinal Barrier Damage and Gut Microbiota in Cyclophosphamide-Induced Immunosuppressed Mice.
SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis.
Canolol Alleviates Ethanol-Induced Gastric Ulcer by Inhibiting p38 MAPK/NF-κB/NLRP3 Pathway.
Synthesis of AgInS(2) quantum dots loaded with celastrol for induction of apoptosis and autophagy in hepatocellular carcinoma cells.
Anethole trithione mitigates LPS/D-Gal-induced acute liver injury by suppressing ROS production and NF-κB activity.
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
RAF1 promotes anlotinib resistance in non-small cell lung cancer by inhibiting apoptosis.
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.
Effect of 1-DNJ on Oxidative Stress-Induced Apoptosis in Porcine Ovarian GCs Through Modulation of the PERK-ATF4/MFN2 Signaling Pathway.
Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress.
Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway.
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.
Lack of ALCAT1 enhances the protective effects of aerobic exercise on kidney in HFpEF mice.
Idebenone improves mitochondrial respiratory activity and attenuates oxidative damage via the SIRT3-SOD2 pathway in a prion disease cell model.
The novel miR_146-Tfdp2 axis antagonizes METH induced neuron apoptosis and cell cycle abnormalities in tree shrew.
A Hybrid Manganese Nanoparticle Simultaneously Eliminates Cancer Stem Cells and Activates STING Pathway to Potentiate Cancer Immunotherapy.
REGγ deficiency ameliorates hepatic ischemia and reperfusion injury in a mitochondrial p66shc dependent manner in mice.
Role of cyclophilin A in aggravation of myocardial ischemia reperfusion injury via regulation of apoptosis mediated by thioredoxin-interacting protein.
Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis.
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Metformin alleviates lung ischemia-reperfusion injury in a rat lung transplantation model.
Lobetyolin Suppresses the Proliferation of Hepatocellular Carcinoma through Activating DUSP1-ERK1/2 Signaling Pathway.
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation.
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
CAPN5 attenuates cigarette smoke extract-induced apoptosis and inflammation in BEAS-2B cells.
Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes.
Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis.
Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis.
Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.
The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation.
Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
MiR-204-5p regulates SIRT1 to promote the endoplasmic reticulum stress-induced apoptosis of inner ear cells in C57BL/6 mice with hearing loss.
Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease.
ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis.
Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.
Mitochondrial Targeted Cerium Oxide Nanoclusters for Radiation Protection and Promoting Hematopoiesis.
Synergistic Effect of Layered Double Hydroxides Nanodosage Form to Induce Apoptosis and Ferroptosis in Breast Cancer.
Anti-Cancer Potency of Copper-Doped Carbon Quantum Dots Against Breast Cancer Progression.
Effective-Component Compatibility of Bufei Yishen Formula III Suppresses Mitochondrial Oxidative Damage in COPD: Via Pkm2/Nrf2 Pathway.
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice.
Combining Network Pharmacology and Transcriptomics to Investigate the Mechanisms of Yujiang Paidu Decoction in the Treatment of Chronic Rhinosinusitis with Nasal Polyps.
Short-Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice.
Nepetoidin B Alleviates Liver Ischemia/Reperfusion Injury via Regulating MKP5 and JNK/P38 Pathway.
α-Synuclein-mediated mitochondrial translocation of cofilin-1 leads to oxidative stress and cell apoptosis in PD.
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Tuina Promotes Repair of Chronic Cervical Muscle Injury by Regulating Satellite Cell Proliferation and Differentiation and Inhibiting Myocyte Apoptosis.
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.
Ligustrazine alleviates spinal cord injury-induced neuropathic pain by inhibiting the TLR4/NF-κB signaling pathway.
Integrating network pharmacology with experimental validation to investigate the mechanism of Wuwei Zishen formula in improving perimenopausal syndrome.
PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.
KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer.
CENPW knockdown inhibits progression of bladder cancer through inducing cell cycle arrest and apoptosis.
TXNDC12 inhibits pancreatic tumor cells ferroptosis by regulating GSH/GGT7 and promotes its growth and metastasis.
CSF2 Impairs Nrf2 Signaling through the Akt/Mtor Pathway in the Development of Bladder Cancer.
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity.
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway.
Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota.
Molecular targets and mechanisms of Sijunzi decoction in the treatment of Parkinson's disease: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation.
Japanese encephalitis virus infection induces mitochondrial-mediated apoptosis through the proapoptotic protein BAX.
Targeting autophagy: polydatin's role in inducing cell death in AML.
The NEDD4/FLRT2 axis regulates NSCLC cell stemness.
Comprehensive analysis of lactylation-related gene sets and mitochondrial functions in gastric adenocarcinoma: implications for prognosis and therapeutic strategies.
Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.
YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes.
Host factor RBMX2 promotes epithelial cell apoptosis by downregulating APAF-1's Retention Intron after Mycobacterium bovis infection.
Screening mitochondria-related biomarkers in skin and plasma of atopic dermatitis patients by bioinformatics analysis and machine learning.
The therapeutic mechanism of Compound Lurong Jiangu Capsule for the treatment of cadmium-induced osteoporosis: network pharmacology and experimental verification.
YY1-induced lncRNA00511 promotes melanoma progression via the miR-150-5p/ADAM19 axis.
Identification of key programmed cell death genes for predicting prognosis and treatment sensitivity in colorectal cancer.
Neoadjuvant immunotherapy plus chemotherapy for squamous cell carcinoma of the paranasal sinus: a case report.
Hyperosmotic cold shock mouse melanoma cells encapsulated with doxorubicin for targeted treatment of melanoma.
Decreased expression of LncRNA CRYM-AS1 promotes apoptosis through the Hippo-YAP1 signaling pathway leading to diabetic erectile dysfunction.
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
Hsa_circ_0001615 downregulation inhibits esophageal cancer development through miR-142-5p/β-catenin.
The long noncoding RNA MIR4435-2HG enhances the migration, promotion, and glycolysis of nonsmall cell lung cancer cells by targeting the miR-371a-5p/SOX2/PI3K/Akt axis.
New molecular mechanisms of quercetin in improving recurrent spontaneous abortion based on in-depth network pharmacology and molecular docking.
Listeria monocytogenes: possible mechanism of infection of goat uterus and its effects on uterine autophagy and cell apoptosis.
Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.
HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway.
ACAT1 suppresses clear cell renal cell carcinoma progression by AMPK mediated fatty acid metabolism.
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress.
Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury.
The protective effects of Axitinib on blood-brain barrier dysfunction and ischemia-reperfusion injury in acute ischemic stroke.
Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.
HSPB8 attenuates lipopolysaccharide‑mediated acute lung injury in A549 cells by activating mitophagy.
ESF1 positively regulates MDM2 and promotes tumorigenesis.
Full-length GSDME mediates pyroptosis independent from cleavage.
ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats.
Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis.
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Pyrimidine compounds BY4003 and BY4008 inhibit glioblastoma cells growth via modulating JAK3/STAT3 signaling pathway.
Aerobic exercise alleviates skeletal muscle aging in male rats by inhibiting apoptosis via regulation of the Trx system.
NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells.
Targeting metabolic reprogramming to overcome drug resistance in advanced bladder cancer: insights from gemcitabine- and cisplatin-resistant models.
PKC-δ Promotes IL-1β-Induced Apoptosis of Rat Chondrocytes and Via Activating JNK and P38 MAPK Pathways.
Combining the novel FLT3 and MERTK dual inhibitor MRX-2843 with venetoclax results in promising antileukemic activity against FLT3-ITD AML.
Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Isotoosendanin exerts anti-tumor effects in NSCLC by enhancing the stability of SHP-2 and inhibiting the JAK/STAT3 pathway.
Gastrodin relieves Parkinson's disease-related motor deficits by facilitating the MEK-dependent VMAT2 to maintain dopamine homeostasis.
B. glomerulata promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT/mTOR pathway.
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis.
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis.
Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway.
PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT.
CD226 implicated in Akt-dependent apoptosis of CD4(+) T cell contributes to asthmatic pathogenesis.
LncRNA OIP5-AS1 regulates ferroptosis and mitochondrial dysfunction-mediated apoptosis in spinal cord injury by targeting the miR-128-3p/Nrf2 axis.
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.
Tetrahydroberberine Prevents Ovariectomy-Induced Bone Loss by Inhibiting RANKL-Induced Osteoclastogenesis and Promoting Osteoclast Apoptosis.
Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis.
Palliative effect of rotating magnetic field on glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating osteoblast differentiation.
Dietary bitter ginger-derived zerumbone improved memory performance during aging through inhibition of the PERK/CHOP-dependent endoplasmic reticulum stress pathway.
Establishment of XRD fourier fingerprint identification method of realgar decoction pieces and its anti-tumor activity in tumor-in-situ transplanted mice.
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway.
Chitosan-Modified AgNPs Efficiently Inhibit Swine Coronavirus-Induced Host Cell Infections via Targeting the Spike Protein.
Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.
A New Class of Gold(I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2.
DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk.
CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway.
Minocycline alleviates lipopolysaccharide-induced cardiotoxicity by suppressing the NLRP3/Caspase-1 signaling pathway.
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Role of secreted frizzled-related protein 5 in granulosa cells of hu sheep ovaries.
IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-κB signaling pathways to promote wound healing.
Win-win integration: A mitochondria targeted AIE photosensitizer for hypochlorite detection and type I & type II photodynamic therapy.
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway.
LncRNA PCIF1 promotes aerobic glycolysis in A549/DDP cells by competitively binding miR-326 to regulate PKM expression.
Inhibiting lncRNA NEAT1 Increases Glioblastoma Response to TMZ by Reducing Connexin 43 Expression.
Ginsenoside Rg1 treats chronic heart failure by downregulating ERK1/2 protein phosphorylation.
HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA.
Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway.
Mangiferin activates the nuclear factor erythroid 2-related factor pathway to protect SOD1-G93A induced NSC-34 motor neurons from oxidative stress and apoptosis.
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation.
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives.
Lenvatinib acts on platelet‑derived growth factor receptor β to suppress the malignant behaviors of gastric cancer cells.
The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1.
Study on the mechanism of macrophages activated by phosphoesterified rehmanniae polysaccharide on human gastric cancer cells.
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax.
Huperzine A targets Apolipoprotein E: A potential therapeutic drug for diabetic nephropathy based on omics analysis.
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis.
Methylglyoxal induces endothelial cell apoptosis and coronary microvascular dysfunction through regulating AR-cPLA(2) signaling.
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Preparation of photo-controlled release ROS-responsive Ce6/elemene co-loaded liposomes and study on the effect on enhancing apoptosis of NMIBC.
Effects of exogenous hydrogen sulfide and honokiol intervention on the proliferation, apoptosis, and calcium signaling pathway of rat enteric glial cells.
A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus.
The expression and role of SUZ12 in lung adenocarcinoma.
Modified EBP-bFGF targeting endogenous renal extracellular matrix protects against renal ischemia-reperfusion injury in rats.
N-Acetylcysteine assists muscle development in offspring of mice subjected to maternal heat stress during pregnancy.
Effect of dapagliflozin on pulmonary vascular remodeling in rats with chronic hypoxic pulmonary arterial hypertension.
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Flavopiridol induces cell cycle arrest and apoptosis by interfering with CDK1 signaling pathway in human ovarian granulosa cells.
PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms.
MiR-155-5p regulates autophagy and apoptosis of glioma cells through RICTOR.
Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages.
Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb.: A network pharmacology analysis and transcriptomics integrated experimental verification.
Mechanism of Zhishi Xiebai Guizhi decoction to treat atherosclerosis: Insights into experiments, network pharmacology and molecular docking.
Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats.
Erianin inhibits the progression of pancreatic cancer by directly targeting AKT and ASK1.
Promotion of Raf-1/ASK1 complex formation by corylin inhibits cell apoptosis in myocardial ischemia/reperfusion injury.
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway.
MYO6 contributes to tumor progression and enzalutamide resistance in castration-resistant prostate cancer by activating the focal adhesion signaling pathway.
Synergistic effects of bloom helicase (BLM) inhibitor AO/854 with cisplatin in prostate cancer.
Gentiopicroside Attenuates Lithium/Pilocarpine-Induced Epilepsy Seizures by Down-Regulating NR2B/CaMKII/CREB and TLR4/NF-κB Signaling Pathways in the Hippocampus of Mice.
Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway.
Fluid shear stress-mediated Piezo1 alleviates osteocyte apoptosis by activating the PI3K/Akt pathway.
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.
Regorafenib promotes antitumor progression in melanoma by reducing RRM2.
Apoptosis, Mitochondrial Autophagy, Fission, and Fusion Maintain Mitochondrial Homeostasis in Mouse Liver Under Tail Suspension Conditions.
The deubiquitinase OTUD3 stabilizes IRP2 expression to reduce hippocampal neuron ferroptosis via the p53/PTGS2 pathway to ameliorate cerebral ischemia-reperfusion injury.
Elevated circulating LncRNA NORAD fosters endothelial cell growth and averts ferroptosis by modulating the miR-106a/CCND1 axis in CAD patients.
Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1.
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease.
Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure.
LncRNA Pvt1 aggravates cardiomyocyte apoptosis via the microRNA-216/Ccnd3 axis.
A quinoline-2-thione derivative as a novel chemotherapy drug candidate displays anti-tumor activity in vitro and in vivo.
Discovery of SIRT1-Activating Hydrogen Sulfide Donating Derivatives for Efficient Resistant of Myocardial Ischemic Injury.
Downregulation of CASC15 attenuates the symptoms of polycystic ovary syndrome by affecting granulosa cell proliferation and regulating ovarian follicular development.
Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury: Impact on the regulation of germ cell proliferation and apoptosis.
Regulation of cervical cancer via G15-mediated inhibition of G protein-coupled estrogen receptor.
Donafenib inhibits PARP1 expression and induces DNA damage, in combination with PARP1 inhibitors promotes apoptosis in liver cancer cells.
Fluorene-9-bisphenol impaired male fertility through disrupting the testicular function and local microenvironment.
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
RBM5 induces motor neuron apoptosis in hSOD1(G93A)-related amyotrophic lateral sclerosis by inhibiting Rac1/AKT pathways.
The effect of repetitive magnetic stimulation on neuronal apoptosis and PI3K/Akt protein expression in rats with incomplete spinal cord injury.
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress.
Surface nanocoating-based universal platform for programmed delivery of microorganisms in complicated digestive tract.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Combined treatment with Aronia berry extract and oligomeric proanthocyanidins exhibit a synergistic anticancer efficacy through LMNB1-AKT signaling pathways in colorectal cancer.
Resolvin E1 and Inhibition of BLT2 Signaling Attenuate the Inflammatory Response and Improve One-Lung Ventilation-Induced Lung Injury.
Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway.
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes.
Naringin Induces ROS-Stimulated G(1) Cell-Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Cells.
Silver Nanoparticles Loaded With Oleuropein Alleviates LPS-Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor-Mediated Inflammation and Apoptosis in Rats.
Ferulic Acid Protects Human Lens Epithelial Cells Against UVA-Induced Oxidative Damage by Downregulating the DNA Demethylation of the Keap1 Promoter.
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
High levels of mitochondrial dynamics, autophagy, and apoptosis contribute to stable testicular status in hibernating Daurian ground squirrels.
A novel format of TNF-α binding affibody molecule ameliorate coronary artery endothelial injury in a mouse model of Kawasaki disease.
The dual role of ATG7: Regulation of autophagy and apoptosis in porcine ovarian follicular granulosa cells.
β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway.
Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer.
Small Nuclear Ribonucleoprotein Polypeptides B and B1 Promote Osteosarcoma Progression via Activating the Ataxia-Telangiectasia Mutated Signaling Pathway through Ribonucleotide Reductase Subunit M2.
L-NRB alleviates amyotrophic lateral sclerosis by regulating P11-Htr4 signaling pathway.
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer.
Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy.
Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury.
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis.
Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma.
Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation.
NEDD4L Suppresses Proliferation and Promotes Apoptosis by Ubiquitinating RAC2 Expression and Acts as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from Apostichopus japonicus on Human Colon Cancer HCT116 Cells.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis.
HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis.
Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12.
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.
Effect and underlying mechanism of a photochemotherapy dual-function nanodrug delivery system for head and neck squamous cell carcinoma.
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway.
Ankrd1 regulates endogenous cardiac regeneration in mice by modulating cyclin D1.
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury.
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.
DNA Damage-Sensitized metal phenolic nanosynergists potentiate Low-Power phototherapy for osteosarcoma therapy.
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Gastrodin against oxidative stress-inflammation crosstalk via inhibiting mtDNA/TLR9 and JAK2/STAT3 signaling to ameliorate ischemic stroke injury.
SHANK2-AS3: A potential biomarker for Parkinson's disease and its role in neuronal apoptosis via NF-κB signaling in SH-SY5Y cells.
Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) Against Non-Small-Cell Lung Cancer: Elucidating Effective Ingredients and Mechanism of Action.
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
The attenuating effects of serine against cadmium induced immunotoxicity through regulating M1/M2 and Th1/Th2 balance in spleen of C57BL/6 mice.
Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells.
Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury.
Luteolin prevents cadmium-induced PC12 cell death by suppressing the Akt/mTOR signaling pathway.
Chlorogenic acid improves the development of porcine parthenogenetic embryos by regulating oxidative stress and ameliorating mitochondrial function.
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in inflammatory bowel disease by targeting TLR2.
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap.
Carnosol alleviates sepsis-induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2-related factor 2/sirtuin-3 signaling pathway to attenuate oxidative damage.
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.
Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage.
Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
miR-148a-3p regulates proliferation and apoptosis of idiopathic gingival fibroma by targeting NPTX1.
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma.
ARF6 promotes Streptococcus suis suilysin induced apoptosis in HBMECs.
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation.
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Heme oxygenase 1 (HO1) regulates autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway of yak Sertoli cells.
Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation.
Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage.
Identification of MACC1 as a potential biomarker for pulmonary arterial hypertension based on bioinformatics and machine learning.
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways.
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis.
Non-oxidized and oxidized flaxseed orbitides differently induce HepG2 cell apoptosis: involvement of cellular uptake and membrane death receptor DR4.
Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma.
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo signaling pathway.
Icariside I reduces breast cancer proliferation, apoptosis, invasion, and metastasis probably through inhibiting IL-6/STAT3 signaling pathway.
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia.
Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy.
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway.
miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL.
Salvianolic acid A alleviates H(2)O(2)-induced endothelial oxidative injury via miR-204-5p.
Rotenone activates the LKB1-AMPK-ULK1 signaling pathway to induce autophagy and apoptosis in rat thoracic aortic endothelial cells.
Targeted Drug Therapy for Senescent Cells Alleviates Unilateral Ureteral Obstruction-Induced Renal Injury in Rats.
YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells.
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma.
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells.
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
ADPN Regulates Oxidative Stress-Induced Follicular Atresia in Geese by Modulating Granulosa Cell Apoptosis and Autophagy.
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure-Activity Relationship and Potential Target.
Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology.
Efficacy and Safety of Asparagusic Acid against Echinococcus multilocularis In Vitro and in a Murine Infection Model.
PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma.
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model.
Cadmium exacerbates liver injury by remodeling ceramide metabolism: Multiomics and laboratory evidence.
A unique circ_0067716/EIF4A3 double-negative feedback loop impacts malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Betulinic acid inhibits the proliferation of human laryngeal carcinoma cells through reactive oxygen species-mediate mitochondrial apoptotic pathway.
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis.
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
Minocycline attenuates the bilirubin-induced developmental neurotoxicity through the regulation of innate immunity and oxidative stress in zebrafish embryos.
Pterostilbene protects against H(2) O(2) -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats.
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis.
Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart.
NCAPD2 promotes the malignant progression of oral squamous cell carcinoma via the Wnt/β-catenin pathway.
Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice.
Homoharringtonine induces apoptosis of mammary carcinoma cells by inhibiting the AKT/mTOR signaling pathway.
Golden bifid treatment regulates gut microbiota and serum metabolites to improve myocardial dysfunction in cecal ligation and puncture-induced sepsis mice.
Ramelteon alleviates myocardial ischemia/reperfusion injury (MIRI) through Sirt3--dependent regulation of cardiomyocyte apoptosis.
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury.
Synthesis, antitumor activity evaluation of 2-selenocyano-3-selenocyanoalkyloxyestradiols with a bisselenocyanate structure.
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer.
Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration.
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke.
Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma.
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Combined metabolomic and proteomic analysis of sepsis related acute liver injury and its pathogenesis research.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice.
Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin.
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.
Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia.
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.
Pan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis.
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
The effect of selenium on the proliferation of bovine endometrial epithelial cells in a lipopolysaccharide-induced damage model.
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway.
Metformin switches cell death modes to soothe the apical periodontitis via ZBP1.
IL-13 alleviates acute kidney injury and promotes regeneration via activating the JAK-STAT signaling pathway in a rat kidney transplantation model.
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells.
Trilobolide-6-O-isobutyrate exerts anti-tumor effects on cholangiocarcinoma cells through inhibiting JAK/STAT3 signaling pathway.
Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis.
Network pharmacology prediction, molecular docking and in vitro experiment explored the potential mechanism of Gaoyuan'an capsule in improving hypoxia tolerance.
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling.
Effects of Dityrosine on Lactic Acid Metabolism in Mice Gastrocnemius Muscle During Endurance Exercise via the Oxidative Stress-Induced Mitochondria Damage.
Red fluorescent BODIPY-based nanoparticles for targeted cancer imaging-guided photodynamic therapy.
ATP5me alleviates high glucose-induced myocardial cell injury.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity.
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Jiangqi Pingxiao formula regulates dendritic cell apoptosis in an autophagy-dependent manner through the AMPK/mTOR pathway in a murine model of OVA-induced asthma.
Effects of gas signaling molecule SO(2) in cardiac functions of hyperthyroid rats.
The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis.
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice.
Beneficial effects of human umbilical cord mesenchymal stem cell (HUCMSC) transplantation on cyclophosphamide (CTX)-induced premature ovarian failure (POF) in Tibetan miniature pigs.
GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis.
RGS2 attenuates alveolar macrophage damage by inhibiting the Gq/11-Ca(2+) pathway during cowshed PM2.5 exposure, and aberrant RGS2 expression is associated with TLR2/4 activation.
Dual-specificity phosphatase 26 protects against kidney injury caused by ischaemia-reperfusion through restraint of TAK1-JNK/p38-mediated apoptosis and inflammation of renal tubular epithelial cells.
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression.
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Exosomes Derived from Mesenchymal Stem Cells Increase the Viability of Damaged Endometrial Cells via the miR-99b-5p/PCSK9 Axis.
Menstrual Blood-Derived Endometrial Stem Cell Transplantation Improves Male Reproductive Dysfunction in T1D Mice by Enhancing Antioxidative Capacity.
Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis.
Structural characterization and improves cognitive disorder in ageing mice of a glucomannan from Dendrobium huoshanense.
A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis.
The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels.
POSTN knockdown suppresses IL-1β-induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF-κB pathway and alleviates intervertebral disc degeneration.
12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation.
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1.
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.
Neobractatin induces pyroptosis of esophageal cancer cells by TOM20/BAX signaling pathway.
The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy.
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens.
Mechanistic study of heat shock protein 60-mediated apoptosis in DF-1 cells.
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling.
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway.
Icariin improves oxidative stress injury during ischemic stroke via inhibiting mPTP opening.
Hypoxia-inducible factor prolyl hydroxylase inhibitor alleviates heatstroke-induced acute kidney injury by activating BNIP3-mediated mitophagy.
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway.
Thonzonium bromide inhibits progression of malignant pleural mesothelioma through regulation of ERK1/2 and p38 pathways and mitochondrial uncoupling.
WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis.
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling.
Topiramate suppresses peri-infarct spreading depolarization and improves outcomes in a rat model of photothrombotic stroke.
Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway.
Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy.
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma.
Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma.
Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice.
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Bradykinin protects nucleus pulposus cells from tert-butyl hydroperoxide-induced damage and delays intervertebral disc degeneration.
SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells.
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy.
Intestinal microbiota via NLRP3 inflammasome dependent neuronal pyroptosis mediates anxiety-like behaviour in mice exposed to 3.5 GHz radiofrequency radiation.
Stereo-selective cardiac toxicity induced by metconazole via oxidative stress and the wnt/β-catenin signaling pathway in zebrafish embryos.
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function.
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke.
GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
Overexpressed FKBP5 mediates colorectal cancer progression and sensitivity to FK506 treatment via the NF-κB signaling pathway.
Therapeutic potential of vitamin D3 in mitigating high glucose‑induced renal damage: Mechanistic insights into oxidative stress inhibition and TXNIP/NLRP3 signaling pathway blockade.
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis.
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice.
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice.
Estradiol contributes to sex differences in resilience to sepsis-induced metabolic dysregulation and dysfunction in the heart via GPER-1-mediated PPARδ/NLRP3 signaling.
The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows.
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation.
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells.
Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction.
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Eurochevalierines A-I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5.
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
Quercetin attenuated ropivacaine-induced neurotoxicity in SH-SY5Y cells through upregulating Pim1 and enhancing autophagy.
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Deciphering the Effects of the PYCR Family on Cell Function, Prognostic Value, Immune Infiltration in ccRCC and Pan-Cancer.
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model.
Gut-derived metabolite 3-methylxanthine enhances cisplatin-induced apoptosis via dopamine receptor D1 in a mouse model of ovarian cancer.
Enhanced therapeutic impact of Shikonin-encapsulated exosomes in the inhibition of colorectal cancer progression.
Hypoxia-enhanced YAP1-EIF4A3 interaction drives circ_0007386 circularization by competing with CRIM1 pre-mRNA linear splicing and promotes non-small cell lung cancer progression.
Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.
PRAME promotes proliferation of multiple myeloma cells through CTMP/Akt/p21/CCND3 axis by ubiquitinating CTMP and p21.
CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs).
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration.
Ultrasound-responsive Bi(2)MoO(6)-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer.
Targeting of G protein-coupled receptor 39 alleviates angiotensin II-induced renal damage by reducing ribonucleotide reductase M2.
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway.
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Caveolin-1 scaffolding domain-derived peptide enhances erectile function by regulating oxidative stress, mitochondrial dysfunction, and apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury.
Melatonin Exerts an Anti-Panoptoic Role in Spinal Cord Ischemia-Reperfusion Injured Rats.
Oridonin suppresses the growth of glioblastoma cells via inhibiting Hippo/YAP axis.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.
miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ(1-40) -induced SH-SY5Y cells by increasing NEP expression.
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.
Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer.
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling.
Chemo-immunotherapy by dual-enzyme responsive peptide self-assembling abolish melanoma.
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity.
CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression.
The P38MAPK/ATF2 signaling pathway is involved in PND in mice.
Carfilzomib suppressed LDHA-mediated metabolic reprogramming by targeting ATF3 in esophageal squamous cell carcinoma.
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
hUC-MSC-EV-miR-24 enhances the protective effect of dexmedetomidine preconditioning against myocardial ischemia-reperfusion injury through the KEAP1/Nrf2/HO-1 signaling.
The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition.
Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC.
Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway.
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR.
let-7g sensitized liver cancer cells to 5-fluorouracil by downregulating ABCC10 expression.
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Hsa_circ_0013561 promotes progression of nasopharyngeal carcinoma by activating JAK2/STAT3 signaling pathway.
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling.
Arsenic-induced downregulation of BRWD3 suppresses proliferation and induces apoptosis in lung adenocarcinoma cells through the p53 and p65 pathways.
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells.
Celastrol Alleviates Mitochondrial Oxidative Stress and Brain Injury After Intracerebral Hemorrhage by Promoting OPA1-Dependent Mitochondrial Fusion.
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma.
Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway.
Unlocking the role of EIF5A: A potential diagnostic marker regulating the cell cycle and showing negative correlation with immune infiltration in lung adenocarcinoma.
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Protective effect of apelin-13 on ventilator-induced acute lung injury.
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer.
Targeting ENPP1 depletion may be a promising therapeutic strategy for treating oral squamous cell carcinoma via cytotoxic autophagy-related apoptosis.
Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline.
Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
The lncRNA GAS5 upregulates ANXA2 to mediate the macrophage inflammatory response during atherosclerosis development.
Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells.
The effect and mechanism of selenium supplementation on the proliferation capacity of bovine endometrial epithelial cells exposed to lipopolysaccharide in vitro under high cortisol background.
Circ-phkb promotes cell apoptosis and inflammation in LPS-induced alveolar macrophages via the TLR4/MyD88/NF-kB/CCL2 axis.
Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
Astaxanthin Inhibits H(2)O(2)-Induced Excessive Mitophagy and Apoptosis in SH-SY5Y Cells by Regulation of Akt/mTOR Activation.
circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression.
Cath-KP, a novel peptide derived from frog skin, prevents oxidative stress damage in a Parkinson's disease model.
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway.
DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis.
Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction.
Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway.
Autophagic and apoptotic proteins in goat corpus luteum and the effect of Adiponectin/AdipoRon on luteal cell autophagy and apoptosis.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway.
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth.
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Gentiopicroside inhibits the progression of gastric cancer through modulating EGFR/PI3K/AKT signaling pathway.
E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis.
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Mechanism of Xiaojianzhong decoction in alleviating aspirin-induced gastric mucosal injury revealed by transcriptomics and metabolomics.
Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression.
Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy.
Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway.
Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax.
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Alisol A Exerts Neuroprotective Effects Against HFD-Induced Pathological Brain Aging via the SIRT3-NF-κB/MAPK Pathway.
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cascade.
Synergistic effect of adavosertib and fimepinostat on acute myeloid leukemia cells by enhancing the induction of DNA damage.
Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2.
Iron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases.
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands.
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation.
Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression.
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition.
The augmentation of cytotoxic immune cell functionality through physical exertion bolsters the potency of chemotherapy in models of mammary carcinoma.
Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer.
Sinigrin improves cerebral ischaemia-reperfusion injury by inhibiting the TLR4 pathway-mediated oxidative stress.
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.
USF2 promotes autophagy and proliferation in chronic lymphocytic leukemia by inhibiting STUB1-induced NFAT5 ubiquitination.
Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway.
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Inhibiting Liver Autophagy and Promoting Hepatocyte Apoptosis by Schistosoma japonicum Infection.
Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice.
Rapid Discovery of Aβ(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Integrin α(4) Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction.
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Atractylenolide II Suppresses Glycolysis and Induces Apoptosis by Blocking the PADI3-ERK Signaling Pathway in Endometrial Cancer Cells.
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.
Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice.
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer.
Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis.
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
Baicalein improves Na(2)SeO(3) induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat.
Jingfang Granule mitigates Coxsackievirus B3-induced myocardial damage by modulating mucolipin 1 expression.
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
IGF-PLGA microspheres promote angiogenesis and accelerate skin flap repair and healing by inhibiting oxidative stress and regulating the Ang 1/Tie 2 signaling pathway.
Curcumin triggers the Wnt/β-catenin pathway and shields neurons from injury caused by intermittent hypoxia.
MiR-200b-3p elevates 5-FU sensitivity in cholangiocarcinoma cells via autophagy inhibition by targeting KLF4.
Quercetin attenuates cadmium-induced hepatotoxicity by suppressing oxidative stress and apoptosis in rat.
Effects of sulforaphane on prostate cancer stem cells-like properties: In vitro and molecular docking studies.
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress.
Erxian decoction ameliorates myocardial tissue damage through activating PI3K/AKT signaling pathway in ovariectomized rats.
In silico and in vivo verification of the mechanism of formononetin in treating hepatocellular carcinoma.
Exploring the roles and therapeutic implications of melatonin-mediated KLF6 in the development of intracranial aneurysm.
Focused Ultrasound Combined With Microbubbles Attenuate Symptoms in Heroin-Addicted Mice.
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction.
miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).
Exposure to Polypropylene Microplastics Causes Cardiomyocyte Apoptosis Through Oxidative Stress and Activation of the MAPK-Nrf2 Signaling Pathway.
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
LncRNA 93358 Aggravates the Apoptosis of Myocardial Cells After Ischemia-Reperfusion by Mediating the PI3K/AKT/mTOR Pathway.
A cisplatin and disulphiram co-loaded inclusion complex overcomes drug resistance by inhibiting cancer cell stemness in non-small cell lung cancer.
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
Angelica sinensis polysaccharides mitigate cadmium-induced apoptosis in layer chicken chondrocytes by inhibiting the JNK signaling pathway.
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Self-assembled metal-polyphenolic based multifunctional nanomedicine to improve therapy treatment of pancreatic cancer by inhibition of glutamine metabolism.
Tanshinone IIA Exerts Cardioprotective Effects Through Improving Gut-Brain Axis Post-Myocardial Infarction.
Critical role of apoptosis in MeCP2-mediated epithelial-mesenchymal transition of ARPE-19 cells.
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
Mechanism of ginsenoside Rb(3) against OGD/R damage based on metabonomic and PCR array analyses.
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent.
Altingia chinensis petroleum ether extract suppresses NSCLC via induction of apoptosis, attenuation of EMT, and downregulation of PI3K/Akt pathway.
Chidan Tuihuang granule modulates gut microbiota to influence NOD1/RIPK2 pathway in cholestatic liver injury recovery.
Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection.
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.
Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.
Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.
Mechanistic study of quercetin in the treatment of hepatocellular carcinoma with diabetes via MEK/ERK pathway.
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Identification of a nomogram predicting overall survival based on ADAP2-related apoptosis genes in gliomas.
Tenovin-6 exhibits inhibitory effects on the growth of Sonic Hedgehog (SHH) medulloblastoma, as evidenced by both in vitro and in vivo studies.
Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats.
Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.
miR-10b-5p promotes tumor growth by regulating cell metabolism in liver cancer via targeting SLC38A2.
MiR-490-3p promotes cell apoptosis and cell-cycle arrest in osteosarcoma via the modulation of CDCA8/ATF3 by targeting NUSAP1.
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Falcarindiol improves functional recovery and alleviates neuroinflammation after spinal cord injury by inhibiting STAT/MAPK signaling pathways.
Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTOR signaling pathway.
Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve.
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
The Pathogenic Role of Expanded CD8⁺CD28(null) Angiogenic T Cells in ANCA-Associated Vasculitis.
Curcumin activates the Wnt/β-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: A study based on network pharmacology and experimental verification.
Colorectal cancer cell-derived exosomal miRNA-372-5p induces immune escape from colorectal cancer via PTEN/AKT/NF-κB/PD-L1 pathway.
Excess Ub-K48 Induces Neuronal Apoptosis in Alzheimer's Disease.
Ku70 silencing aggravates oxygen-glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes.
Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways.
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways.
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway.
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Taxifolin attenuates hepatic ischemia-reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy.
Transcription factor PRRX1-activated ANXA6 facilitates EGFR-PKCα complex formation and enhances cisplatin sensitivity in bladder cancer.
Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression.
Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved.
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor.
H(2)S-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K/AKT pathway.
Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
Long noncoding RNA ANRIL alleviates hypoxia-induced pulmonary microvascular endothelial cell damage.
Digitoxin inhibits ICC cell properties via the NF‑κB/ST6GAL1 signaling pathway.
Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells.
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis.
Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma.
Mometasone furoate inhibits tumor progression and promotes apoptosis through activation of the AMPK/mTOR signaling pathway in osteosarcoma.
Succinylation of 14-3-3 theta by CPT1A promotes survival and paclitaxel resistance in nasal type extranodal natural killer/T-cell lymphoma.
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
Downregulation of circ-RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3).
SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response.
miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway.
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration.
Maintaining calcium homeostasis as a strategy to alleviate nephrotoxicity caused by evodiamine.
3,3'-Diindolylmethane inhibits the proliferation of esophageal squamous cell carcinoma cells via downregulation of STIM1.
SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1α.
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary.
Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer.
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
miR-200a-3p-enriched MSC-derived extracellular vesicles reverse erectile function in diabetic rats by targeting Keap1.
Novel meroterpene-like compounds inhibit ferroptosis through Fe(2+) chelation.
MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
N-acetylcysteine stimulates the proliferation and differentiation in heat-stressed skeletal muscle cells.
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Canadine Platinum(IV) Complexes Targeting Epithelial-Mesenchymal Transition as Antiproliferative and Antimetastatic Agents.
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
The Effects of trans-10, cis-12 Conjugated Linoleic Acid on the Production Performance of Dairy Cows and the Expression and Transcription Regulation of Lipid Metabolism-Related Genes in Bovine Mammary Epithelial Cells.
Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone.
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Bacillus subtilis alleviates excessive apoptosis of intestinal epithelial cells in intrauterine growth restriction suckling piglets via the members of Bcl-2 and caspase families.
Synergistic effects of plasma-activated medium in combination with Baicalin against neuronal damage.
Gastrin-related circRNA_0017065 promotes the proliferation and metastasis of colorectal cancer through the miR-3174/RBFOX2 axis.
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Revealing the Mechanism of Esculin in Treating Renal Cell Carcinoma Based on Network Pharmacology and Experimental Validation.
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis.
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
2,3-Diphosphoglyceric Acid Alleviating Hypoxic-Ischemic Brain Damage through p38 MAPK Modulation.
Effect of acacetin on inhibition of apoptosis in Helicobacter pylori-infected gastric epithelial cell line.
MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma.
Exploration of the mechanism of fraxetin in treating acute myeloid leukemia based on network pharmacology and experimental verification.
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
Mitochondria-Targeted Multifunctional Nanoprodrugs by Inhibiting Metabolic Reprogramming for Combating Cisplatin-Resistant Lung Cancer.
Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics.
Leonurus japonicus Houtt. modulates neuronal apoptosis in intracerebral hemorrhage: Insights from network pharmacology and molecular docking.
FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway.
Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma.
Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis.
A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling.
LncRNA LOXL1-AS1 promotes proliferation and invasion and inhibits apoptosis in retinoblastoma by regulating the MAPK signaling pathway.
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro.
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers.
Nicotine suppresses crystalline silica-induced astrocyte activation and neuronal death by inhibiting NF-κB in the mouse hippocampus.
Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet.
Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments.
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection.
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease.
Chloroxine inhibits pancreatic cancer progression through targeted antagonization of the PI3K/AKT/mTOR signaling pathway.
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Mn-Anti-CTLA4-CREKA-Sericin Nanotheragnostics for Enhanced Magnetic Resonance Imaging and Tumor Immunotherapy.
STAT3 ameliorates truncated tau-induced cognitive deficits.
Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling.
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.
Human amniotic mesenchymal stromal cell-derived exosomes promote neuronal function by inhibiting excessive apoptosis in a hypoxia/ischemia-induced cerebral palsy model: A preclinical study.
Triphenylphosphonium-linked derivative of hecogenin with enhanced antiproliferative activity: Design, synthesis, and biological evaluation.
Knocking down GRAMD1C expression reduces 6-OHDA-induced apoptosis in PC12 cells.
Regulatory mechanism of perinatal nonylphenol exposure on cardiac mitochondrial autophagy and the PINK1/Parkin signaling pathway in male offspring rats.
Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy-Ferroptosis Combined Therapy for Gastric Cancer.
NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16.
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.
The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis.
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway.
Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer.
Icariin ameliorates LPS-induced acute lung injury in mice via complement C5a-C5aR1 and TLR4 signaling pathways.
6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway.
B-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer.
Acupuncture Extended the Thrombolysis Window by Suppressing Blood-Brain Barrier Disruption and Regulating Autophagy-Apoptosis Balance after Ischemic Stroke.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis.
Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage.
Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson's disease.
Rat Hepatocytes Protect against Lead-Cadmium-Triggered Apoptosis Based on Autophagy Activation.
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.
Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome.
Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis.
Construction and validation of a hypoxia-related gene signature to predict the prognosis of breast cancer.
CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression.
Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate.
Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog.
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells.
Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts from Sanghuangporusvaninii.
Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal.
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway.
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
MiR-125b-5p/STAT3 Axis Regulates Drug Resistance in Osteosarcoma Cells by Acting on ABC Transporters.
Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway.
Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells.
Study on Neuroprotective Mechanism of Houshiheisan in Ischemic Stroke Based on Transcriptomics and Experimental Verification.
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD(+)/Sirt3 Pathway.
Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.
miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R.
Mini-αA Upregulates the miR-155-5p Target Gene CDK2 and Plays an Antiapoptotic Role in Retinal Pigment Epithelial Cells during Oxidative Stress.
Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage.
Exosomes from Adipose-Derived Stem Cells Alleviate Dexamethasone-Induced Bone Loss by Regulating the Nrf2/HO-1 Axis.
Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
Resveratrol Suppresses Bupivacaine-Induced Spinal Neurotoxicity in Rats by Inhibiting Endoplasmic Reticulum Stress via SIRT1 Modulation.
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis.
Bacterial lipoprotein plays an important role in the macrophage autophagy and apoptosis induced by Salmonella typhimurium and Staphylococcus aureus.
Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway.
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88.
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease.
Neuroplastin 65 deficiency reduces amyloid plaque formation and cognitive deficits in an Alzheimer's disease mouse model.
Esomeprazole Alleviates Cisplatin Resistance by Inhibiting the AKT/mTOR Pathway in Ovarian Cancer Cells.
NEK6 Promotes the Progression of Osteosarcoma Through Activating STAT3 Signaling Pathway by Down-Regulation of miR-26a-5p.
MALAT1 knockdown alleviates myocardial injury in mice with severe acute pancreatitis via the miR-374a/Sp1/Wnt/β-catenin pathway.
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Integration of RRBS and RNA-seq unravels the regulatory role of DNMT3A in porcine Sertoli cell proliferation.
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
18-α-glycyrrhetinic acid alleviates oxidative damage in periodontal tissue by modulating the interaction of Cx43 and JNK/NF-κB pathways.
Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling.
Pterostilbene attenuates microglial inflammation and brain injury after intracerebral hemorrhage in an OPA1-dependent manner.
The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats.
Adjuvant therapy with Huatan Sanjie Granules improves the prognosis of patients with primary liver cancer: a cohort study and the investigation of its mechanism of action based on network pharmacology.
Promotion of colorectal cancer cell death by ezetimibe via mTOR signaling-dependent mitochondrial dysfunction.
Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway.
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma.
CYR61 promotes colorectal carcinoma progression via activating epithelial-mesenchymal transition.
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism.
Triptolide inhibits the progression of Glioblastoma U251 cells via targeting PROX1.
A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors.
EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a comprehensive bioinformatics analysis and experiment verification.
Combined effects of EMP and RF field on emotional behavior in mice.
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.
TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI.
Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng-Nian-Shu in perimenopausal syndrome.
Baicalin promotes random-pattern skin flap survival by inducing autophagy via AMPK-regulated TFEB nuclear transcription.
Apelin-Overexpressing Neural Stem Cells in Conjunction with a Silk Fibroin Nanofiber Scaffold for the Treatment of Traumatic Brain Injury.
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway.
Downregulation of ACC expression suppresses cell viability and migration in the malignant progression of breast cancer.
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats.
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway.
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.
Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway.
Loss and recovery of myocardial mitochondria in mice under different tail suspension time: Apoptosis and mitochondrial fission, fusion and autophagy.
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels.
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Resveratrol-Coated Gold Nanoflowers for CT Imaging and Apoptosis/Photothermal Synergistic Therapy of Malignant Melanoma.
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Comprehensive Analysis of the Transcriptome-Wide m(6)A Methylome in Shaziling Pig Testicular Development.
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma.
Stereospecificity of Ginsenoside AD-1 and AD-2 Showed Anticancer Activity via Inducing Mitochondrial Dysfunction and Reactive Oxygen Species Mediate Cell Apoptosis.
CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation.
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.
Tat-P combined with GAPR1 releases Beclin1 to promote autophagy and improve Bronchopulmonary dysplasia model.
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
POFUT1 promotes gastric cancer progression through Notch/Wnt dual signaling pathways dependent on the parafibromin-NICD1-β-catenin complex.
Long-term iTBS Improves Neural Functional Recovery by Reducing the Inflammatory Response and Inhibiting Neuronal Apoptosis Via miR-34c-5p/p53/Bax Signaling Pathway in Cerebral Ischemic Rats.
Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.
Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway.
Identification and evaluation of a novel PARP1 inhibitor for the treatment of triple-negative breast cancer.
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Honokiol alleviates radiation-induced premature ovarian failure via enhancing Nrf2.
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
The role of HIF-1α-mediated autophagy in ionizing radiation-induced testicular injury.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis.
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
The role of NADPH oxidase 1 in alcohol-induced oxidative stress injury of intestinal epithelial cells.
miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a.
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
The effect of small molecule inhibitor NSC348884 on nucleophosmin 1-mutated acute myeloid leukemia cells.
Effect of doramectin on programmed cell death pathway in glioma cells.
Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms.
Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder.
Myeloid-specific deletion of Capns1 attenuates myocardial infarction injury via restoring mitochondrial function and inhibiting inflammasome activation.
Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway.
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM(2.5) exposure by downregulating the PGC-1α/SIRT3 signaling pathway.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity.
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway.
Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer.
A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo.
Moschus ameliorates glutamate-induced cellular damage by regulating autophagy and apoptosis pathway.
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration.
Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination.
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death.
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells.
[Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma].
Mutation of the ETS1 3'UTR interacts with miR-216a-3p to regulate granulosa cell apoptosis in sheep.
The effects of protein-rich extract from Rhizoma Gastrodiae against cerebral ischemia/reperfusion injury via regulating MAPK and PI3K/AKT signaling pathway.
The Yeast and Hypha Phases of Candida krusei Induce the Apoptosis of Bovine Mammary Epithelial Cells via Distinct Signaling Pathways.
Dendrobium officinale polysaccharide Converts M2 into M1 Subtype Macrophage Polarization via the STAT6/PPAR-r and JAGGED1/NOTCH1 Signaling Pathways to Inhibit Gastric Cancer.
METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
Peptide Characterization of Bovine Myocardium Hydrolysates and Its Ameliorative Effects on Doxorubicin-Induced Myocardial Injury in H9c2 Cells and in Mice.
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis.
FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Dendrobium mixture ameliorates hepatic injury induced by insulin resistance in vitro and in vivo through the downregulation of AGE/RAGE/Akt signaling pathway.
Rutaecarpine Mitigates Cognitive Impairment by Balancing Mitochondrial Function Through Activation of the AMPK/PGC1α Pathway.
Suppression of the gut microbiota-bile acid-FGF19 axis in patients with atrial fibrillation.
The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice.
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer.
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.
Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice.
Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways.
Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.
Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix.
Phenothiazines reduced autophagy in ischemic stroke through endoplasmic reticulum (ER) stress-associated PERK-eIF2α pathway.
Plasma metabonomic study on the effect of Para‑hydroxybenzaldehyde intervention in a rat model of transient focal cerebral ischemia.
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma.
Glutathione Might Attenuate Arsenic-Induced Liver Injury by Modulating the Foxa2-XIAP Axis to Reduce Oxidative Stress and Mitochondrial Apoptosis.
A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.
The novel lncRNA-9802/miR-1646 axis affects cell proliferation of DF-1 by regulating Bax/Bcl-2 signaling pathway.
The role of the Gas6/TAM signal pathway in the LPS-induced pulmonary epithelial cells injury.
The eNOS-induced leonurine's new role in improving the survival of random skin flap.
Trans-anethole pretreatment ameliorates hepatic ischemia-reperfusion injury via regulation of soluble epoxide hydrolase.
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.
Activation of the p53 signaling pathway by piRNA-MW557525 overexpression induces a G0/G1 phase arrest thus inhibiting neuroblastoma growth.
Endoplasmic Reticulum-Targeted Aggregation-Induced Emission Luminogen for Synergetic Tumor Ablation with Glibenclamide.
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis.
Shenmai injection ameliorates doxorubicin-induced myocardial injury by suppressing autophagy-apoptosis via miR-30a.
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer.
MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer.
Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication.
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration.
DJ1 Ameliorates AD-like Pathology in the Hippocampus of APP/PS1 Mice.
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury.
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice.
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Methylcrotonyl-CoA carboxylase subunit 1 (MCCA) regulates multidrug resistance in multiple myeloma.
Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells.
Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines.
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer.
Agrocybe cylindracea fucoglucogalactan induced lysosome-mediated apoptosis of colorectal cancer cell through H3K27ac-regulated cathepsin D.
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
Tumor necrosis factor-α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways.
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity.
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro.
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target.
Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow.
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication.
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.
Experimental study of the effects of absorbable gelatin sponge and non‑absorbable polyvinyl alcohol particle material used in transcatheter arterial embolization on liver tissues.
Inhibitory effect and mechanism of hirsuteine on NCI‑H1299 lung cancer cell lines.
Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization.
Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1.
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway.
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1.
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Inhibition of AGEs-RAGE-PP2A Axis Alleviates Cognitive Impairment after Chronic Heart Failure.
Porphin e6 complex loaded with gold nanorod mesoporous silica enhances photodynamic therapy in ovarian cancer cells in vitro.
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma.
A Novel Mitovirus PsMV2 Facilitates the Virulence of Wheat Stripe Rust Fungus.
Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer.
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
The therapeutic mechanism of Yuye decoction on type 2 diabetes mellitus based on network pharmacology and experimental verification.
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives.
20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.
Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway.
The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts.
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via modulating the PKCα/Cx43 signaling pathway.
MicroRNA-22-3p Regulates the Apoptosis of Lens Epithelial Cells Through Targeting KLF6 in Diabetic Cataracts.
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Electroacupuncture alleviates early brain injury via modulating microglia polarization and suppressing neuroinflammation in a rat model of subarachnoid hemorrhage.
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Study on the effect of 5-aminolevulinic acid-mediated photodynamic therapy combined with cisplatin on human ovarian cancer OVCAR-3 cells.
Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway.
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects.
Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p.
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim.
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Neuroprotective effects of oxymatrine on hypoxic-ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway.
GDNF-Loaded Polydopamine Nanoparticles-Based Anisotropic Scaffolds Promote Spinal Cord Repair by Modulating Inhibitory Microenvironment.
Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling.
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
Dioscin ameliorates silica-aggravated systemic lupus erythematosus via suppressing apoptosis and improving LC3-associated phagocytosis in MRL/lpr mice.
pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway.
SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.
SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway.
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
Autophagy-Targeted Calcium Phosphate Nanoparticles Enable Transarterial Chemoembolization for Enhanced Cancer Therapy.
Semaglutide inhibits ischemia/reperfusion-induced cardiomyocyte apoptosis through activating PKG/PKCε/ERK1/2 pathway.
The Wnt/β-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury.
PTMA binds to HMGB1 to regulate mitochondrial oxidative phosphorylation and thus affect the malignant progression of esophageal squamous cell carcinoma.
CPT1A modulates PI3K/Akt/mTOR pathway to promote preeclampsia.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation.
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway.
Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway.
Dietary Lactobacillus reuteri prevent from inflammation mediated apoptosis of liver via improving intestinal microbiota and bile acid metabolism.
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
MiR-214-3p may alleviate T-2 toxin-induced chondrocyte apoptosis and matrix degradation by regulating NF-κB signaling pathway in vitro.
Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.
Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells.
Dexpramipexole ameliorates cognitive deficits in sepsis-associated encephalopathy through suppressing mitochondria-mediated pyroptosis and apoptosis.
Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells.
Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival.
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.
Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2.
taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation.
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway.
Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway.
Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis.
Hawthorn fruit extract protect against MC-LR-induced hepatotoxicity by attenuating oxidative stress and apoptosis.
Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance.
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
1,4,5,6,7,8‑Hexahydropyrido[4,3‑d]pyrimidine inhibits HepG2 cell proliferation, migration and invasion, and induces apoptosis through the upregulation of miR‑26b‑5p by targeting CDK8.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
αCGRP deficiency aggravates pulmonary fibrosis by activating the PPARγ signaling pathway.
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway.
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3(+)CD4(+)T cells against PAHs carcinogenicity.
Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
TWIST1 rescue calcium overload and apoptosis induced by inflammatory microenvironment in S. aureus-induced osteomyelitis.
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy.
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells.
Effect of Lactobacillus delbrueckii subsp. lactis on vaginal radiotherapy for gynecological cancer.
[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Sodium houttuyfonate exerts its neuroprotection effect by inhibiting the M1 microglia polarization in a TLR4/NF-κB signal pathway.
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p.
Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner.
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
The Aldose Reductase Inhibitor Epalrestat Maintains Blood-Brain Barrier Integrity by Enhancing Endothelial Cell Function during Cerebral Ischemia.
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p.
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
ATPIF1 alleviates oxygen glucose deprivation/reoxygenation-induced astrocyte injury in vitro: A rat model of ischemic brain injury.
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.
Periostin regulates LPS-induced apoptosis via Nrf2/HO-1 pathway in periodontal ligament fibroblasts.
Thioredoxin1 is a target to attenuate diabetes‑induced RPE cell dysfunction in human ARPE19 cells by alleviating oxidative stress.
CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization.
Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments.
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression.
Integration of proteomics and network toxicology reveals the mechanism of mercury chloride induced hepatotoxicity, in mice and HepG2 cells.
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p.
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
The protective effect of lncRNA NEAT1/miR-122-5p/Wnt1 axis on hippocampal damage in hepatic ischemic reperfusion young mice.
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury.
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1.
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Downregulation of CLDN6 inhibits cell migration and invasion and promotes apoptosis by regulation of the JAK2/STAT3 signaling pathway in hepatocellular carcinoma.
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.
USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling.
Novel Protein C6ORF120 Promotes Apoptosis through Mitochondria-dependent Pathway in CD4 (+)T Lymphocytes.
NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
MiR-29c-5p regulates the function of buffalo granulosa cells to induce follicular atresia by targeting INHBA.
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells.
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma.
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus.
Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study.
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway.
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Melatonin Increases Proliferation and Decreases Apoptosis of GC-1 spg Cells by Upregulating the Expression of circTec.
Metabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury.
Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Protective Mechanism of Ethyl Gallate against Intestinal Ischemia-Reperfusion Injury in Mice by in Vivo and in Vitro Studies Based on Transcriptomics.
Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease.
Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.
Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.
CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
HAPLN3 inhibits apoptosis and promotes EMT of clear cell renal cell carcinoma via ERK and Bcl-2 signal pathways.
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis.
Heat enhances the inhibitory effect of lipopolysaccharide on duck granulosa cell proliferation and steroid biosynthesis in vitro.
Berberine enhances autophagic flux by activating the Nrf2 signaling pathway in bovine endometrial epithelial cells to resist LPS-induced apoptosis.
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells.
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
MitoQ Protects Ovarian Organoids against Oxidative Stress during Oogenesis and Folliculogenesis In Vitro.
Network and experimental pharmacology on mechanism of Si-Wu-tang improving ovarian function in a mouse model of premature ovarian failure induced by cyclophosphamide.
Exploring the synergic mechanism of Ligusticum striatum DC. and borneol in attenuating BMECs injury and maintaining tight junctions against cerebral ischaemia based on the HIF-1α/VEGF signalling pathway.
Alginate Oligosaccharides Prevent Dextran-Sulfate-Sodium-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Modulating Gut Microbiota.
5-Hydroxytryptophan inhibits β-casein biosynthesis and promotes goat mammary epithelial cell apoptosis through the JAK2/STAT5a axis and the HTR7.
Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats.
Glucotropaeolin Promotes Apoptosis by Calcium Dysregulation and Attenuates Cell Migration with FOXM1 Suppression in Pancreatic Cancer Cells.
Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism.
Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway.
Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer.
Dioscin reduced chemoresistance for colon cancer and analysis of sensitizing targets.
ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d -GALACTOSE-INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3.
Effects of chronic realgar exposure on liver lipidome in mice and identification sensitive lipid biomarker model for realgar-induced liver damage.
Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy.
Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1.
Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus.
Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway.
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370.
Corilagin alleviates intestinal ischemia/reperfusion injury by relieving oxidative stress and apoptosis via AMPK/Sirt1-autophagy pathway.
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke.
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Polyphenol-driven facile assembly of a nanosized acid fibroblast growth factor-containing coacervate accelerates the healing of diabetic wounds.
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Taxifolin ameliorates cigarette smoke-induced chronic obstructive pulmonary disease via inhibiting inflammation and apoptosis.
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Low temperature exposure inhibits proliferation and induces apoptosis of bovine subcutaneous preadipocytes via p38 MAPK/JNK activation.
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms.
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Dual regulation of Akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening.
Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis.
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: Novel perspectives on the mechanism underlying DEHP genotoxicity in male germ cells.
Piceatannol and 3'-Hydroxypterostilbene Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.
Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation.
Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction.
Ursolic acid induces apoptosis and pyroptosis in Reh cells by upregulating of the JNK signalling pathway based on network pharmacology and experimental validation.
Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner.
Simvastatin inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma through KLF2 signal.
TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
Endonuclease G promotes preeclampsia by regulating the Wnt signaling pathway.
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells.
CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway.
Effects and possible mechanisms of combined exposure to noise and carbon monoxide on male reproductive system in rats.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Uqcr11 alleviates oxidative stress and apoptosis after traumatic brain injury.
Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle.
BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway.
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.
Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.
Inhibition of S100A9 alleviates neurogenic pulmonary edema after subarachnoid hemorrhage.
Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis.
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Riboflavin protects against heart failure via SCAD-dependent DJ-1-Keap1-Nrf2 signalling pathway.
Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
Inhibiting NF-κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer.
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells.
Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion.
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway.
Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis.
Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer.
Umbelliferone attenuates cisplatin-induced acute kidney injury by inhibiting oxidative stress and inflammation via NRF2.
Probiotic-fermented Qushi decoction alleviates reserpine-induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an Aβ 1-42 -induced Alzheimer's disease rat model by activating BDNF/TrkB signaling transduction.
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Cynanchum komarovii extract for the treatment of rheumatoid arthritis by acting on synovial cells in vitro and in vivo.
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A.
Choline induced cardiac dysfunction by inhibiting the production of endogenous hydrogen sulfide in spontaneously hypertensive rats.
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling.
Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness.
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
Canthaxanthin Attenuates the Vascular Aging or Endothelial Cell Senescence by Inhibiting Inflammation and Oxidative Stress in Mice.
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy.
Mesenchymal stem cell exosomes inhibit nucleus pulposus cell apoptosis via the miR-125b-5p/TRAF6/NF-κB pathway axis.
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Reactive Oxygen Species Damage Bovine Endometrial Epithelial Cells via the Cytochrome C-mPTP Pathway.
PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer.
TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis.
Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathy.
Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway.
Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer.
Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats.
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Natural killer cells strengthen antitumor activity of cisplatin by immunomodulation and ameliorate cisplatin-induced side effects.
hsa_circ_0000417 downregulation suppresses androgen receptor expression and apoptotic signals in human foreskin fibroblasts via sponging miR-6756-5p.
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.
The MyD88 inhibitor, ST2825, induces cell cycle arrest and apoptosis by suppressing the activation of the NF‑κB/AKT1/p21 pathway in pancreatic cancer.
Effect of evernic acid on human breast cancer MCF-7 and MDA-MB-453 cell lines via thioredoxin reductase 1: A molecular approach.
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway.
A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression.
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
miR-101-5p overexpression suppresses the proliferation of goat spermatogonial stem cells by targeting EZH2.
Role of Autophagy and Apoptosis in Aluminum Exposure-Induced Liver Injury in Rats.
Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.
Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
New murine model of alcoholic hepatitis in obesity-induced metabolic-associated fatty liver disease.
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.
Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway.
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis.
Silibinin exerts neuroprotective effects against cerebral hypoxia/reoxygenation injury by activating the GAS6/Axl pathway.
Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer.
ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest.
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro.
LncRNA-PEAK1 promotes neuronal apoptosis after intracerebral hemorrhage by miR-466i-5p/caspase 8 axis.
Mitochondrial division inhibitor (mdivi-1) inhibits proliferation and epithelial-mesenchymal transition via the NF-κB pathway in thyroid cancer cells.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia.
High expression of centromere protein N as novel biomarkers for gastric adenocarcinoma.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy.
Inhibition of autophagic flux by the curcumin analog EF-24 and its antiproliferative effect on MCF-7 cancer cells.
Perilla frutescens L. alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation.
The effect of regulating MCU expression on experimental ischemic brain injury.
Decreased autophagic activity of detrusor cells is involved in the inflammatory response of interstitial cystitis/bladder pain syndrome.
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway.
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy.
Roles of TRPV4 in Regulating Circulating Angiogenic Cells to Promote Coronary Microvascular Regeneration.
Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway.
Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Knockdown of KDM5B Leads to DNA Damage and Cell Cycle Arrest in Granulosa Cells via MTF1.
Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota.
Potential Effect of Glutamine in the Improvement of Intestinal Stem Cell Proliferation and the Alleviation of Burn-Induced Intestinal Injury via Activating YAP: A Preliminary Study.
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer.
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
[Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway].
[High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway].
The emerging role of lysine succinylation in ovarian aging.
Antioxidant, Immunostimulatory, and Anticancer Properties of Hydrolyzed Wheat Bran Mediated through Macrophages Stimulation.
AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer.
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway.
Renal Ischemia-reperfusion Injury Attenuated by Exosomes Extracted From Splenic Ischemic Preconditioning Models.
The preventive and therapeutic effect of repetitive transcranial magnetic stimulation on radiation-induced brain injury in mice.
Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.
Isoliquiritin Ameliorates Cisplatin-Induced Renal Proximal Tubular Cell Injury by Antagonizing Apoptosis, Oxidative Stress and Inflammation.
The Selenium Yeast vs Selenium Methionine on Cell Viability, Selenoprotein Profile and Redox Status via JNK/ P38 Pathway in Porcine Mammary Epithelial Cells.
6-Shogaol Inhibits Oxidative Stress-Induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 Axis.
Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy.
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling.
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.
MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B.
MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway.
LincRNA-p21 Upregulates Nuclear Orphan Receptor Nr4a2 and Aggravates Myocardial Ischemia/Reperfusion Injury via Targeting MiR-466i-5p.
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.
A Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer.
Bixin Prevents Colorectal Cancer Development through AMPK-Activated Endoplasmic Reticulum Stress.
MTMR14 Alleviates Chronic Obstructive Pulmonary Disease as a Regulator in Inflammation and Emphysema.
Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.
PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.
Development of a Costimulatory Molecule Signature to Predict Prognosis, Immune Landscape, and Response to Immune Therapy for Hepatocellular Carcinoma.
Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice.
Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Resveratrol Induces Apoptosis, Suppresses Migration, and Invasion of Cervical Cancer Cells by Inhibiting the Hedgehog Signaling Pathway.
Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells.
Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis.
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK.
Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer.
EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress.
Xiaotan Sanjie Decoction Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion through lncRNA-ATB and miR-200A.
Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo.
Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora.
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway.
Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis.
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway.
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m(6)A Modification of MAT2A Pre-mRNA by METTL16.
The lncRNA KIF9-AS1 Accelerates Hepatocellular Carcinoma Growth by Recruiting DNMT1 to Promote RAI2 DNA Methylation.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury.
SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis.
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats.
Propofol Upregulates MicroRNA-30b to Inhibit Excessive Autophagy and Apoptosis and Attenuates Ischemia/Reperfusion Injury In Vitro and in Patients.
Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells.
Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway.
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Protective Effects of Vitamin C against Neomycin-Induced Apoptosis in HEI-OC1 Auditory Cell.
Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1.
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.
Novel Application of Eupatilin for Effectively Attenuating Cisplatin-Induced Auditory Hair Cell Death via Mitochondrial Apoptosis Pathway.
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction.
Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.
Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Targeted Nanobubbles of PD-L1 mAb Combined with Doxorubicin as a Synergistic Tumor Repressor in Hepatocarcinoma.
Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.
Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy.
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Expression and potential role of FOSB in glioma.
The Ameliorative Effect of JNK Inhibitor D-JNKI-1 on Neomycin-Induced Apoptosis in HEI-OC1 Cells.
Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways.
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
CSTF2 Acts as a Prognostic Marker Correlated with Immune Infiltration in Hepatocellular Carcinoma.
BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53.
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Abscopal effects of thoracic X-ray radiation on spermatogenesis in mice.
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway.
Effect of ribose-glycated BSA on histone demethylation.
Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes.
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
ABCA12 Promotes Proliferation and Migration and Inhibits Apoptosis of Pancreatic Cancer Cells Through the AKT Signaling Pathway.
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
FGF2 Is Protective Towards Cisplatin-Induced KGN Cell Toxicity by Promoting FTO Expression and Autophagy.
Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1.
High expression of B4GALT1 is associated with poor prognosis in acute myeloid leukemia.
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke.
Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway.
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells.
HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance.
Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.
Number 2 Feibi Recipe Inhibits H(2)O(2)-Mediated Oxidative Stress Damage of Alveolar Epithelial Cells by Regulating the Balance of Mitophagy/Apoptosis.
Induction of Collagen I by CXCL10 in Ovarian Theca-Stroma Cells via the JNK Pathway.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
Comprehensive analysis of hypoxia-related genes for prognosis value, immune status, and therapy in osteosarcoma patients.
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway.
BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model.
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats.
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction.
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
Investigation of the inhibition effect of 1,2,3,4,6-pentagalloyl-β-D-glucose on gastric cancer cells based on a network pharmacology approach and experimental validation.
CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.
Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress.
The Novel lncRNA RP9P Promotes Colorectal Cancer Progression by Modulating miR-133a-3p/FOXQ1 Axis.
Hinokiflavone Inhibits Growth of Esophageal Squamous Cancer By Inducing Apoptosis via Regulation of the PI3K/AKT/mTOR Signaling Pathway.
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Knockdown of Annexin A2 Enhances Radiosensitivity by Increasing G2/M-Phase Arrest, Apoptosis and Activating the p38 MAPK-HSP27 Pathway in Nasopharyngeal Carcinoma.
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Therapeutic targeting of ARID1A and PI3K/AKT pathway alterations in cholangiocarcinoma.
A nanobody-based molecular toolkit for ubiquitin-proteasome system explores the main role of survivin subcellular localization.
A mitochondria-targeted nano-platform for pancreatic cancer therapy.
Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy.
TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.
A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells.
Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway.
Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.
Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock.
SERPINA5 promotes tumour cell proliferation by modulating the PI3K/AKT/mTOR signalling pathway in gastric cancer.
Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.
Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.
Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.
Chaihujialonggumulitang shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of oxidative stress and apoptosis.
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression.
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy.
A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model.
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer.
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome.
FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Zearalenone Promotes LPS-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Accelerates Bovine Mammary Epithelial Cell Apoptosis.
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma.
Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation.
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
Yajieshaba prevents lipopolysaccharide-induced intestinal barrier injuryanti-inflammatory and anti-apoptosis.
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Effect of NMB-regulated ERK1/2 and p65 signaling pathway on proliferation and apoptosis of cervical cancer.
Protective Effect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells.
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2.
Polymyxin B Reduces Brain Injury in Ischemic Stroke Rat Through a Mechanism Involving Targeting ESCRT-III Machinery and RIPK1/RIPK3/MLKL Pathway.
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model.
SCO-spondin-derived peptide NX210 rescues neurons from cerebral ischemia/reperfusion injury through modulating the Integrin-β1 mediated PI3K/Akt pathway.
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Xanthotoxol suppresses non-small cell lung cancer progression and might improve patients' prognosis.
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Ischemia-Reperfusion Injury and Promote Survival of Skin Flaps in Rats.
Indole-3-propionic Acid Attenuates HI-Related Blood-Brain Barrier Injury in Neonatal Rats by Modulating the PXR Signaling Pathway.
Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury.
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma.
Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils.
Polygonatum cyrtonema Hua Polysaccharides Protect BV2 Microglia Relief Oxidative Stress and Ferroptosis by Regulating NRF2/HO-1 Pathway.
Domino hepatocyte transplantation using explanted human livers with metabolic defects attenuates D-GalN/LPS-induced acute liver failure.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice.
MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats.
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM).
Knockdown of TTC9 inhibits the proliferation, migration and invasion, but induces the apoptosis of lung adenocarcinoma cells.
Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration.
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.
Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
A novel synthetic chalcone derivative, 2,4,6-trimethoxy-4'-nitrochalcone (Ch-19), exerted anti-tumor effects through stimulating ROS accumulation and inducing apoptosis in esophageal cancer cells.
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.
Effect of rapamycin treatment on oocyte in vitro maturation and embryonic development after parthenogenesis in yaks.
Ellagic Acid Alleviates Mice Intestinal Ischemia-Reperfusion Injury: A Study Based on Transcriptomics Combined with Functional Experiments.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression.
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice.
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.
Long-Term Consumption of Food-Derived Chlorogenic Acid Protects Mice against Acetaminophen-Induced Hepatotoxicity via Promoting PINK1-Dependent Mitophagy and Inhibiting Apoptosis.
The effect of lncRNA MIR155HG-modified MSCs and exosome delivery to synergistically attenuate vein graft intimal hyperplasia.
Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.
Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.
MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis.
Suffruticosol C-Mediated Autophagy and Cell Cycle Arrest via Inhibition of mTORC1 Signaling.
6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer.
WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC.
Reactive Oxygen Species- and Cell-Free DNA-Scavenging Mn(3)O(4) Nanozymes for Acute Kidney Injury Therapy.
CD93 promotes acute myeloid leukemia development and is a potential therapeutic target.
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Integrated strategy of network pharmacology, molecular docking, HPLC-DAD and mice model for exploring active ingredients and pharmacological mechanisms of Penthorum chinense Pursh against alcoholic liver injury.
Dietary N(ε)-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice.
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
DJ-1 Protein Inhibits Apoptosis in Cerebral Ischemia by Regulating the Notch1 and Nuclear Factor Erythroid2-Related Factor 2 Signaling Pathways.
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.
Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway.
Maslinic Acid Inhibits Myocardial Ischemia-Reperfusion Injury-Induced Apoptosis and Necroptosis via Promoting Autophagic Flux.
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB.
Novel chloroquine derivative suppresses melanoma cell growth by DNA damage through increasing ROS levels.
NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation.
LncRNA SOX2OT facilitates LPS-induced inflammatory injury by regulating intercellular adhesion molecule 1 (ICAM1) via sponging miR-215-5p.
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.
Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway.
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage.
Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow.
Label-free Raman spectroscopy characterizes signatures of inflammation and fibrosis in the silicosis.
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin.
Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment.
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.
Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1.
Dietary phillygenin supplementation ameliorates aflatoxin B(1)-induced oxidative stress, inflammation, and apoptosis in chicken liver.
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Chlorin e6 mediated photodynamic therapy triggers resistance through ATM-related DNA damage response in lung cancer cells.
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway.
PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer.
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis.
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Expressions and significances of CTSL, the target of COVID-19 on GBM.
In situ injectable hydrogel-loaded drugs induce anti-tumor immune responses in melanoma immunochemotherapy.
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Oxycodone relieves permeability damage and apoptosis of oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cells through ras homolog family member A (RhoA)/ Rho-associated coiled-coil containing kinases (ROCK)/ myosin light chain 2 (MLC2) signal.
Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice.
Blocking protease-activated receptor 4 alleviates liver injury induced by brain death.
Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Autophagy Promotes α-Amanitin-Induced Apoptosis of Hepa1-6 Liver Cells.
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway.
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy.
Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway.
Long noncoding RNA H19 mediates neural stem/progenitor cells proliferation, differentiation and apoptosis through the p53 signaling pathway after ischemic stroke.
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells.
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway.
Staphylococcus aureus Induces Goat Endometrial Epithelial Cells Apoptosis via the Autophagy and Endoplasmic Reticulum Stress Pathway.
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Interleukin-4 activates the PI3K/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells.
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Nephrotoxicity evaluation of 3-monochloropropane-1,2-diol exposure in Sprague-Dawley rats using data-independent acquisition-based quantitative proteomics analysis.
Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Inhibition of calpain reduces cell apoptosis by suppressing mitochondrial fission in acute viral myocarditis.
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
microRNA-486-5p is implicated in the cisplatin-induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1.
Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
A pH-Dependent rhodamine fluorophore with antiproliferative activity of bladder cancer in Vitro/Vivo and apoptosis mechanism.
Glis2 inhibits the epithelial-mesenchymal transition and apoptosis of renal tubule cells by regulating the β-catenin signalling pathway in diabetic kidney disease.
Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.
LncRNA SNHG16 promotes colorectal cancer proliferation by regulating ABCB1 expression through sponging miR-214-3p.
Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer.
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Anti-aging effect of phlorizin on D-galactose-induced aging in mice through antioxidant and anti-inflammatory activity, prevention of apoptosis, and regulation of the gut microbiota.
Comparative and mechanistic study of pharmacodynamic difference in anti-breast cancer activity between water and liquor extracts of Xiaojin Pills.
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis.
Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.
Metformin protects 5-Fu-induced chemotherapy oral mucositis by reducing endoplasmic reticulum stress in mice.
Protective effect of nicorandil against myocardial ischemia/reperfusion injury mediated via IL33/ST2 signaling pathway.
Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways.
Melatonin improves bisphenol A-induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK-BLV cells.
MicroRNA profiling reveals miR-145-5p inhibits goat myoblast differentiation by targeting the coding domain sequence of USP13.
Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway.
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.
Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β-catenin signaling pathway.
Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice.
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway.
Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim.
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.
Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells.
Revealing the mechanism of Jiegeng decoction attenuates bleomycin-induced pulmonary fibrosis via PI3K/Akt signaling pathway based on lipidomics and transcriptomics.
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN.
SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism.
Tiao-bu-fei-shen formula promotes downregulation of the caveolin 1-p38 mapk signaling pathway in COPD - Associated tracheobronchomalacia cell model.
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells.
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer.
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling.
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Antitumor activity of Koningic acid in thyroid cancer by inhibiting cellular glycolysis.
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury.
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Circular RNA circUSP13 sponges miR-29c to promote differentiation and inhibit apoptosis of goat myoblasts by targeting IGF1.
TRIM59 promotes osteosarcoma progression via activation of STAT3.
Molecular Mechanism of Aluminum-Induced Oxidative Damage and Apoptosis in Rat Cardiomyocytes.
Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice.
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m(6)A modification.
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.
Inhibition of the proliferation, invasion, migration, and epithelial-mesenchymal transition of prostate cancer cells through the action of ATP1A2 on the TGF-β/Smad pathway.
Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway.
Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway.
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Structural Variability of Lipoarabinomannan Modulates Innate Immune Responses within Infected Alveolar Epithelial Cells.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK/PGC-1α signaling pathway and also induces apoptosis and dysregulated mitophagy in the duck liver.
Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice.
Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension.
Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
Autophagy and apoptosis mediated nano-copper-induced testicular damage.
Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke.
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
Artemisia capillaris Thunb. water extract attenuates adriamycin-induced renal injury by regulating apoptosis through the ROS/MAPK axis.
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment.
Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
MiR-181c suppresses triple-negative breast cancer tumorigenesis by targeting MAP4K4.
Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells.
Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint.
ZFP36 protects against oxygen-glucose deprivation/reoxygenation-induced mitochondrial fragmentation and neuronal apoptosis through inhibiting NOX4-DRP1 pathway.
l-Argine regulates the proliferation, apoptosis and endocrine activity by alleviating oxidative stress in sheep endometrial epithelial cells.
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke.
Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats.
Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways.
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway.
Anticancer effects of myricetin derivatives in non-small cell lung cancer in vitro and in vivo.
Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia-reperfusion injury are mediated by regulating the PI3K/AKT pathway.
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression.
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression.
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway.
Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition - More Than Just ROS-inhibition.
FTO protects human granulosa cells from chemotherapy-induced cytotoxicity.
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy.
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy.
Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model.
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy.
QiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy.
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.
Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro.
Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway.
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX.
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Hesperidin partly ameliorates the decabromodiphenyl ether-induced reproductive toxicity in pubertal mice.
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization.
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Alfalfa saponins inhibit oxidative stress-induced cell apoptosis through the MAPK signaling pathway.
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
FBXL6 depletion restrains clear cell renal cell carcinoma progression.
Para‑hydroxybenzaldehyde against transient focal cerebral ischemia in rats via mitochondrial preservation.
Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control.
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress.
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress.
Effects of betaine on viability, apoptosis, function protein expression and oxidative status in heat-stressed IEC-6 cells.
USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway.
Exosome-transmitted S100A4 induces immunosuppression and non-small cell lung cancer development by activating STAT3.
Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1.
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.
Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury.
LncRNA HIF1A-AS1 Regulates the Cellular Function of HUVECs by Globally Regulating mRNA and miRNA Expression.
Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?
Long noncoding RNA HOTAIR facilitates pulmonary vascular endothelial cell apoptosis via DNMT1 mediated hypermethylation of Bcl-2 promoter in COPD.
Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
HIV-1 gp120 Protein Activates Cyclin-Dependent Kinase 1, a Possible Link to Central Nervous System Cell Death.
Fecal Microbiota Transplantation Alleviated Cerebral Ischemia Reperfusion Injury in Obese Rats.
Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts.
Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice.
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma.
Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis.
GYY4137 ameliorates sepsis-induced cardiomyopathy via NLRP3 pathway.
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function.
MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
Downstream Neighbor of Son Overexpression is Associated With Breast Cancer Progression and a Poor Prognosis.
Nonylphenol inhibited HIF-1alpha regulated aerobic glycolysis and induced ROS mediated apoptosis in rat Sertoli cells.
Effect of low energy shock wave on testicular microenvironment homeostasis in rats.
miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis.
Identification and verification of the role of crucial genes through which methionine restriction inhibits the progression of colon cancer cells.
Cyclometalated iridium(III) dithioformic acid complexes as mitochondria-targeted imaging and anticancer agents.
Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism.
Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways.
Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells.
CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-κB pathway in gastric cancer cells.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H(2)O(2)-induced cardiomyocyte injury.
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.
Myocardium-Targeted Micelle Nanomedicine That Salvages the Heart from Ischemia/Reperfusion Injury.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy.
Investigation of the effects of high cervical spinal cord electrical stimulation on improving neurological dysfunction and its potential mechanism in rats with traumatic brain injury.
Lianhuaqingwen alleviates p53-mediated apoptosis in alveolar epithelial cells to prevent LPS-induced ALI.
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy.
Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway.
Covalent Organic Framework (COF): A Drug and Carrier to Attenuate Retinal Ganglion Cells Death in an Acute Glaucoma Mouse Model.
Sparstolonin B inhibits pancreatic adenocarcinoma through the NF-κB signaling pathway.
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Acetyl CoA synthase 2 potentiates ATG5-induced autophagy against neuronal apoptosis after subarachnoid hemorrhage.
Melatonin Attenuates Ropivacaine-Induced Apoptosis by Inhibiting Excessive Mitophagy Through the Parkin/PINK1 Pathway in PC12 and HT22 Cells.
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer.
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier.
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling.
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway.
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway.
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer.
Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.
Network pharmacology analysis and experimental validation to explore the mechanism of Shenlian extract on myocardial ischemia.
Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice.
NaAsO(2) decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway.
Comprehensive analysis of abnormal expression, prognostic value and oncogenic role of the hub gene FN1 in pancreatic ductal adenocarcinoma via bioinformatic analysis and in vitro experiments.
Inhibitory effect and mechanism of action (MOA) of hirsutine on the proliferation of T-cell leukemia Jurkat clone E6-1 cells.
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
TGR5 Activation Ameliorates Mitochondrial Homeostasis via Regulating the PKCδ/Drp1-HK2 Signaling in Diabetic Retinopathy.
LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5.
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
Expression Level of ADAMTS1 in Granulosa Cells of PCOS Patients Is Related to Granulosa Cell Function, Oocyte Quality, and Embryo Development.
Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria.
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis.
Citric Acid Promoting B Lymphocyte Differentiation and Anti-epithelial Cells Apoptosis Mediate the Protective Effects of Hermetia illucens Feed in ETEC Induced Piglets Diarrhea.
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Secreted Frizzled-Related Protein 5 Protects Against Cardiac Rupture and Improves Cardiac Function Through Inhibiting Mitochondrial Dysfunction.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Erythropoietin Attenuates Experimental Contrast-Induced Nephrology: A Role for the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway.
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway.
EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells.
Shen-fu injection alleviates acute renal injury by reducing cytokine levels and modulating apoptosis in a porcine hemorrhagic shock model.
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Schisandrin Protects against Norepinephrine-Induced Myocardial Hypertrophic Injury by Inhibiting the JAK2/STAT3 Signaling Pathway.
Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats.
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38(-/-) Sepsis Mice.
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Exploring the Therapeutic Mechanism of Tingli Dazao Xiefei Decoction on Heart Failure Based on Network Pharmacology and Experimental Study.
Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway.
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
Imbalance of Autophagy and Apoptosis Induced by Oxidative Stress May Be Involved in Thyroid Damage Caused by Sleep Deprivation in Rats.
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Inhibition of α-Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice.
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Saikosaponin D Inhibits the Proliferation and Promotes the Apoptosis of Rat Hepatic Stellate Cells by Inducing Autophagosome Formation.
Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF.
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10.
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.
USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin.
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1α/IP(3)R signaling pathway.
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Vagal Nerve Stimulation Protects Against Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis.
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress.
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson's Disease Pathology.
Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats.
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments.
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells.
Gαi1 Promoted Proliferation, Migration and Invasion via Activating the Akt-mTOR/Erk-MAPK Signaling Pathway in Renal Cell Carcinoma.
Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma.
Salusin-β Mediates High Glucose-Induced Inflammation and Apoptosis in Retinal Capillary Endothelial Cells via a ROS-Dependent Pathway in Diabetic Retinopathy.
Microarray analysis reveals a potential role of lncRNA expression in remote ischemic preconditioning in myocardial ischemia-reperfusion injury.
lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis.
MALAT-1 is Associated with the Doxorubicin Resistance in U-2OS Osteosarcoma Cells.
SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling.
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation.
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway.
JieZe-1 Alleviates HSV-2 Infection-Induced Genital Herpes in Balb/c Mice by Inhibiting Cell Apoptosis via Inducing Autophagy.
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Ultrasound-Induced Destruction of Nitric Oxide-Loaded Microbubbles in the Treatment of Thrombus and Ischemia-Reperfusion Injury.
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology.
Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach.
The Abscopal Effects of Cranial Irradiation Induce Testicular Damage in Mice.
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas.
Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation.
Clemastine Fumarate Attenuates Myocardial Ischemia Reperfusion Injury Through Inhibition of Mast Cell Degranulation.
miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.
Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study.
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.
Case Report: 7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth.
Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF-κB Signaling Pathway.
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells.
SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease.
Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.
Knockdown of RIPK2 Inhibits Proliferation and Migration, and Induces Apoptosis via the NF-κB Signaling Pathway in Gastric Cancer.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
BLM interaction with EZH2 regulates MDM2 expression and is a poor prognostic biomarker for prostate cancer.
(125)I seed implantation brachytherapy for glottic carcinoma: an experimental and clinical study.
Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway.
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.
High-Risk HPV16 E6 Activates the cGMP/PKG Pathway Through Glycosyltransferase ST6GAL1 in Cervical Cancer Cells.
Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
Downregulating Long Non-coding RNAs CTBP1-AS2 Inhibits Colorectal Cancer Development by Modulating the miR-93-5p/TGF-β/SMAD2/3 Pathway.
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Homoharringtonine inhibits the progression of hepatocellular carcinoma by suppressing the PI3K/AKT/GSK3β/Slug signaling pathway.
Gastrodin protects against high glucose-induced cardiomyocyte toxicity via GSK-3β-mediated nuclear translocation of Nrf2.
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell.
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.
Polystyrene microplastics induce blood-testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats.
miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
Knockdown of PYCR1 suppressed the malignant phenotype of human hepatocellular carcinoma cells via inhibiting the AKT pathway activation.
Expression and purification of a recombinant ELRL-MAP30 with dual-targeting anti-tumor bioactivity.
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
Dual-enzymatically cross-linked gelatin hydrogel promotes neural differentiation and neurotrophin secretion of bone marrow-derived mesenchymal stem cells for treatment of moderate traumatic brain injury.
WAC, a novel GBM tumor suppressor, induces GBM cell apoptosis and promotes autophagy.
Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis.
Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway.
Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration.
Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Tetramethylpyrazine inhibits neutrophil extracellular traps formation and alleviates hepatic ischemia/reperfusion injury in rat liver transplantation.
IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.
miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway.
Systematic screening identifies a TEAD4-S100A13 axis modulating cisplatin sensitivity of oral squamous cell carcinoma cells.
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.
Arctigenin inhibits cholangiocarcinoma progression by regulating cell migration and cell viability via the N-cadherin and apoptosis pathway.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
The regulation of Ero1-alpha in homocysteine-induced macrophage apoptosis and vulnerable plaque formation in atherosclerosis.
Exosomes derived from idiopathic gingival fibroma fibroblasts regulate gingival fibroblast proliferation and apoptosis.
Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells.
Hsa_circ_0004058 inhibits apoptosis of SRA01/04 cells by promoting autophagy via miR-186/ATG7 axis.
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury.
Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway.
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis.
8-Formylophiopogonanone B induces ROS-mediated apoptosis in nasopharyngeal carcinoma CNE-1 cells.
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner.
Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase.
JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12.
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways.
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation.
Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
EF24 exerts cytotoxicity against NSCLC via inducing ROS accumulation.
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
HMGB1 could restrict 1,3-β-glucan induced mice lung inflammation by affecting Beclin1 and Bcl2 interaction and promoting the autophagy of epithelial cells.
Effect of Perinatal Vitamin D Deficiency on Lung Mesenchymal Stem Cell Differentiation and Injury Repair Potential.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Oxidative stress-mediated apoptosis is involved in bisphenol S-induced reproductive toxicity in male C57BL/6 mice.
N-acetylcysteine ameliorate cytotoxic injury in piglets sertoli cells induced by zearalenone and deoxynivalenol.
Moderate mechanical stress suppresses the IL-1β-induced chondrocyte apoptosis by regulating mitochondrial dynamics.
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice.
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide.
miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E(2) Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride.
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.
INHBA transfection regulates proliferation, apoptosis and hormone synthesis in sheep granulosa cells.
Apatinib combined with Keytruda treatment induces apoptosis of gastric carcinoma cells through CES4/miR-616-5p/DUSP2 axis.
Macrophages mediated delivery of chlorin e6 and treatment of lung cancer by photodynamic reprogramming.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis.
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Tβ4 ameliorates oxidative damage and apoptosis through ERK/MAPK and 5-HT1A signaling pathway in Aβ insulted SH-SY5Y cells.
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.
Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney.
3-Epipachysamine B suppresses proliferation and induces apoptosis of breast cancer cell via PI3K/AKT/mTOR signaling pathway.
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.
TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.
The biological characteristics of the canine adenovirus type 1 from fox and the transcriptome analysis of the infected MDCK cell.
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway.
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Chlorogenic acid enhances autophagy by upregulating lysosomal function to protect against SH-SY5Y cell injury induced by H(2)O(2).
Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer.
Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome.
Effects of SPATA6 on proliferation, apoptosis and steroidogenesis of Hu sheep Leydig cells in vitro.
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.
Chloroquine enhances catalpol's ability to promote apoptosis by inhibiting catalpol's autophagy-promoting effect on gastric cancer.
LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics.
Dehydroabietic Acid Is a Novel Survivin Inhibitor for Gastric Cancer.
Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia.
CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys.
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Protective effect of recombinant Lactobacillus plantarum against H(2)O(2)-induced oxidative stress in HUVEC cells.
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Hsa_circ_0056558 regulates cyclin-dependent kinase 6 by sponging microRNA-1290 to suppress the proliferation and differentiation in ankylosing spondylitis.
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis.
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades.
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Cordyceps acid alleviates lung cancer in nude mice.
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury.
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
miR-98-5p protects against cerebral ischemia/reperfusion injury through anti-apoptosis and anti-oxidative stress in mice.
The Phenoxyphenol Compound diTFPP Mediates Exogenous C(2)-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells.
Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential.
HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease.
The Effect of Hispidulin, a Flavonoid from Salvia plebeia, on Human Nasopharyngeal Carcinoma CNE-2Z Cell Proliferation, Migration, Invasion, and Apoptosis.
α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo.
Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids facilitates the repair of cardiotoxin-induced skeletal muscle injury in fat-1 mice.
Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells.
Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-κB/MAPK signaling pathways.
WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling.
Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma.
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
Temperature Variability Does Not Attenuate the Beneficial Effects of Therapeutic Hypothermia on Cellular Apoptosis and Endoplasmic Reticulum Stress in the Cerebral Cortex of a Swine Cardiac Arrest Model.
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein.
SEC61G is upregulated and required for tumor progression in human kidney cancer.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Venlafaxine and L-Thyroxine Treatment Combination: Impact on Metabolic and Synaptic Plasticity Changes in an Animal Model of Coexisting Depression and Hypothyroidism.
Anti-tumor effects of Solanum nigrum L. extraction on C6 high-grade glioma.
DNA methylation mediated RSPO2 to promote follicular development in mammals.
Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity.
TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression.
Hyper-O-GlcNAcylation impairs insulin response against reperfusion-induced myocardial injury and arrhythmias in obesity.
Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer.
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway.
Neuroprotective effects of bone marrow Sca-1(+) cells against age-related retinal degeneration in OPTN E50K mice.
The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS.
Hyaluronic acid/polyethyleneimine nanoparticles loaded with copper ion and disulfiram for esophageal cancer.
Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats.
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Hippocampal alpha-synuclein mediates depressive-like behaviors.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.
Amyloid-β (25-35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice.
Anti-CD19 mAb modified mesoporous titanium dioxide as exclusively targeting vector for efficient B-lymphoblastic leukemia therapy.
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Enteric glial cells exert neuroprotection from hyperglycemia-induced damage via Akt/GSK3β pathway.
Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients.
The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.
Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress.
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress.
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.
The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.
A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Long noncoding RNA GAS5 accelerates diabetic wound healing and promotes lymphangiogenesis via miR-217/Prox1 axis.
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling.
Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.
BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2.
Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway.
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
UHRF1 Knockdown Attenuates Cell Growth, Migration, and Invasion in Cutaneous Squamous Cell Carcinoma.
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.
Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer.
AG490 protects cerebral ischemia/reperfusion injury via inhibiting the JAK2/3 signaling pathway.
A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis.
Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury.
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation.
miR-335-5p suppresses gastric cancer progression by targeting MAPK10.
Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3.
Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice.
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.
A "dual-guide" bioinspired drug delivery strategy of a macrophage-based carrier against postoperative triple-negative breast cancer recurrence.
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
Cigarette smoke induced neural tube defects by down-regulating noggin expression.
Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor-mediated mRNA decay.
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Curcumin Ameliorates Copper-Induced Neurotoxicity Through Inhibiting Oxidative Stress and Mitochondrial Apoptosis in SH-SY5Y Cells.
Autophagy Induction Contributes to the Neuroprotective Impact of Intermittent Fasting on the Acutely Injured Spinal Cord.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.
Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice.
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Yak milk-derived exosomal microRNAs regulate intestinal epithelial cells on proliferation in hypoxic environment.
Targeting MUC1-C reverses the cisplatin resistance of esophageal squamous cell carcinoma in vitro and in vivo.
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.
Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
Protective effect of procyanidin A-type dimers against H(2)O(2)-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway.
MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
AK003290 Protects Myocardial Cells Against Apoptosis and Promotes Cardiac Function Recovery Via miR-539-3p/ErbB4 Axis in Ischemic-Reperfusion Injury.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Sinapic acid attenuates muscle atrophy in streptozotocin-induced diabetic mice.
Danshensu derivative ADTM ameliorates CCl(4)‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis.
RNF43 overexpression attenuates the Wnt/β-catenin signalling pathway to suppress tumour progression in cholangiocarcinoma.
Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats.
Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway.
TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression.
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
miR-142-3p and HMGB1 Are Negatively Regulated in Proliferation, Apoptosis, Migration, and Autophagy of Cartilage Endplate Cells.
MicroRNA-506 has a suppressive effect on the tumorigenesis of nonsmall-cell lung cancer by regulating tubby-like protein 3.
Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.
A novel circular RNA (hsa_circ_0059930)-mediated miRNA-mRNA axis in the lipopolysaccharide-induced acute lung injury model of MRC-5 cells.
MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma.
Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway.
Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis.
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury.
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling.
Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis.
TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.
Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway.
ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy.
EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B.
Ozone induces tolerance against cardiomyocytes oxygen-glucose deprivation/reperfusion through inhibition of autophagy pathway.
Emodin ameliorates acute pancreatitis-induced lung injury by suppressing NLRP3 inflammasome-mediated neutrophil recruitment.
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Vitamin E and selenium supplementation synergistically alleviate the injury induced by hydrogen peroxide in bovine granulosa cells.
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.
Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.
Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway.
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
The screening of drug-induced nephrotoxicity using gold nanocluster-based ratiometric fluorescent probes.
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice.
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway.
Knockdown of enhancer of rudimentary homolog expression attenuates proliferation, cell cycle and apoptosis of melanoma cells.
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells.
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Coaction of hepatic thioredoxin and glutathione systems in iron overload-induced oxidative stress.
CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Elevated Secretion of Aldosterone Increases TG/HDL-C Ratio and Potentiates The Ox-LDL-Induced Dysfunction of HUVEC.
The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells.
Morroniside protects OLN-93 cells against H(2)O(2)-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities.
Salidroside Attenuates Doxorubicin-Induced Cardiac Dysfunction Partially Through Activation of QKI/FoxO1 Pathway.
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
Preclinical Evaluation of Recombinant Human IL15 Protein Fused with Albumin Binding Domain on Anti-PD-L1 Immunotherapy Efficiency and Anti-Tumor Immunity in Colon Cancer and Melanoma.
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation.
Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.
Coibamide A kills cancer cells through inhibiting autophagy.
CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway.
Inhibition of Notch1 signaling reduces hepatocyte injury in nonalcoholic fatty liver disease via autophagy.
Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway.
Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury.
Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma.
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Sodium propionate protect the blood-milk barrier integrity, relieve lipopolysaccharide-induced inflammatory injury and cells apoptosis.
Macrophages-derived exosomal lncRNA LIFR-AS1 promotes osteosarcoma cell progression via miR-29a/NFIA axis.
Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer.
Inhibiting Heat Shock Protein 90 Protects Nucleus Pulposus-Derived Stem/Progenitor Cells From Compression-Induced Necroptosis and Apoptosis.
PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis.
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
miR-214 Protects Against Uric Acid-Induced Endothelial Cell Apoptosis.
miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL.
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
RGS12 is required for the maintenance of mitochondrial function during skeletal development.
Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice.
Shenmai Injection Supresses Glycolysis and Enhances Cisplatin Cytotoxicity in Cisplatin-Resistant A549/DDP Cells via the AKT-mTOR-c-Myc Signaling Pathway.
Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro.
Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.
Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy.
Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway.
Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model.
Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs.
Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
UFM1-Specific Ligase 1 Ligating Enzyme 1 Mediates Milk Protein and Fat Synthesis-Related Gene Expression via the JNK Signaling Pathway in Mouse Mammary Epithelial Cells.
Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway.
Overexpression of BMPER in Ovarian Cancer and the Mechanism by which It Promotes Malignant Biological Behavior in Tumor Cells.
Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression.
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway.
Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma.
Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis.
Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways.
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Septin4 promotes cell death in human colon cancer cells by interacting with BAX.
The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy.
Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis.
Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway.
Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1.
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
URM1 Promoted Tumor Growth and Suppressed Apoptosis via the JNK Signaling Pathway in Hepatocellular Carcinoma.
Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
Derlin-1 Promotes the Progression of Human Hepatocellular Carcinoma via the Activation of AKT Pathway.
β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways.
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
LncRNA MIR503HG Promotes High-Glucose-Induced Proximal Tubular Cell Apoptosis by Targeting miR-503-5p/Bcl-2 Pathway.
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways.
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Selaginellin B induces apoptosis and autophagy in pancreatic cancer cells via the JAK2/STAT3 signaling pathway.
Caspase-8 knockdown suppresses apoptosis, while induces autophagy and chemo-sensitivity in non-small cell lung cancer cells.
miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway.
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling.
Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth.
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.
Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells.
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway.
Long Noncoding RNA TCONS_00016406 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating the miR-687/PTEN Pathway.
Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission.
Isorhamnetin Enhances the Radiosensitivity of A549 Cells Through Interleukin-13 and the NF-κB Signaling Pathway.
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress.
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.
Amniotic Membrane Extract Protects Islets From Serum-Deprivation Induced Impairments and Improves Islet Transplantation Outcome.
Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux.
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Salvianolic Acid B Protects Against Fatty Acid-Induced Renal Tubular Injury via Inhibition of Endoplasmic Reticulum Stress.
Morroniside Inhibits H(2)O(2)-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro.
Polysaccharides of Dendrobium officinale Kimura & Migo Leaves Protect Against Ethanol-Induced Gastric Mucosal Injury via the AMPK/mTOR Signaling Pathway in Vitro and vivo.
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.
α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways.
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy.
AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway.
3D printed in vitro tumor tissue model of colorectal cancer.
Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer.
Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling.
Fusobacterium nucleatum Promotes the Development of Ulcerative Colitis by Inducing the Autophagic Cell Death of Intestinal Epithelial.
Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Hyperbaric oxygen treatment mitigates liver damage in mice with noise exposure.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells.
Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.
MiR-489 aggravates H2O2-induced apoptosis of cardiomyocytes via inhibiting IGF1.
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells.
MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis.
Inhibition of Endoplasmic Reticulum Stress-Mediated Autophagy Enhances the Anticancer Effect of Iodine-125 Seed Radiation on Esophageal Squamous Cell Carcinoma.
α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway.
Maternal exposure to Di-(2-ethylhexyl) phthalate (DEHP) activates the PI3K/Akt/mTOR signaling pathway in F1 and F2 generation adult mouse testis.
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Effects of seawater immersion on open traumatic brain injury in rabbit model.
Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells.
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Overexpression of microRNA-21-5p prevents the oxidative stress-induced apoptosis of RSC96 cells by suppressing autophagy.
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.
Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes from Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis.
Dynamin-related protein-1 promotes lung cancer A549 cells apoptosis through the F-actin/bax signaling pathway.
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma.
Autophagy plays a protective role during Pseudomonas aeruginosa-induced apoptosis via ROS-MAPK pathway.
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Effect of autophagy on irradiation‑induced damage in osteoblast‑like MC3T3‑E1 cells.
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.
Inhibitory effect of Lycium barbarum polysaccharide on sperm damage during cryopreservation.
Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract.
Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1.
Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons.
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice.
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Hepatoprotective effects of Di Wu Yang Gan: A medicinal food against CCl(4)-induced hepatotoxicity in vivo and in vitro.
Titanium Dioxide Nanoparticles Induced HeLa Cell Necrosis under UVA Radiation through the ROS-mPTP Pathway.
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat.
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
EZH2 expression and its role in spermatogonial stem cell self-renewal in goats.
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Knockdown of fatty acid binding protein 4 exacerbates Bacillus Calmette-Guerin infection-induced RAW264.7 cell apoptosis via the endoplasmic reticulum stress pathway.
CaMKII as a key regulator of contrast-induced nephropathy through mPTP opening in HK-2 cells.
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression.
LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts.
miR-130a promotes immature porcine Sertoli cell growth by activating SMAD5 through the TGF-β-PI3K/AKT signaling pathway.
Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC.
Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.
Eva-1 homolog A promotes papillary thyroid cancer progression and epithelial-mesenchymal transition via the Hippo signalling pathway.
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury.
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.
MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma.
Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.
Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Mycoplasma bovis-generated reactive oxygen species and induced apoptosis in bovine mammary epithelial cell cultures.
Gastrodin alleviates bone damage by modulating protein expression and tissue redox state.
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
[IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy].
USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway.
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
miR-362 knock-down promotes proliferation and inhibits apoptosis in porcine immature Sertoli cells by targeting the RMI1 gene.
Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.
Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway.
LINC00963 targeting miR-128-3p promotes acute kidney injury process by activating JAK2/STAT1 pathway.
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
The Association Between Thyroid Injury and Apoptosis, and Alterations of Bax, Bcl-2, and Caspase-3 mRNA/Protein Expression Induced by Nickel Sulfate in Wistar Rats.
Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters.
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer.
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
Lactoferrin Contributes a Renoprotective Effect in Acute Kidney Injury and Early Renal Fibrosis.
Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4(+) T cell apoptosis.
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Pinocembrin mitigates depressive-like behaviors induced by chronic unpredictable mild stress through ameliorating neuroinflammation and apoptosis.
circStrn3 is involved in bone cancer pain regulation in a rat model.
MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.
Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms.
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.
Butyrate alleviates oxidative stress by regulating NRF2 nuclear accumulation and H3K9/14 acetylation via GPR109A in bovine mammary epithelial cells and mammary glands.
MS-275 combined with cisplatin exerts synergistic antitumor effects in human esophageal squamous cell carcinoma cells.
Hsp90 inhibition aggravates adriamycin-induced podocyte injury through intrinsic apoptosis pathway.
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
Stimuli-Responsive Polysaccharide Enveloped Liposome for Targeting and Penetrating Delivery of survivin-shRNA into Breast Tumor.
Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke.
Camellia oil (Camellia oleifera Abel.) attenuates CCl(4)-induced liver fibrosis via suppressing hepatocyte apoptosis in mice.
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
LncRNA FAM66C inhibits pancreatic cancer progression by sponging miR-574-3p.
Danshen formula granule and salvianic acid A alleviate ethanol-induced neurotoxicity.
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Silencing of TPD52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating Akt pathway.
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract.
Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity.
C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium.
Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.
CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma.
The mechanism of PDA/PEI/5-Fu coated esophageal stent material on inhibiting cancer associated pathological cells.
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Long non-coding RNA HAL suppresses the migration and invasion of serous ovarian cancer by inhibiting EMT signaling pathway.
Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats.
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
PHLDA1 is a new therapeutic target of oxidative stress and ischemia reperfusion-induced myocardial injury.
LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p/IGF-1 axis in human granulosa-like tumor cell line KGN.
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Annexin A7 induction of neuronal apoptosis via effect on glutamate release in a rat model of subarachnoid hemorrhage.
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.
Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.
Neuroprotective effects of miR-532-5p against ischemic stroke.
Anti-human serum albumin autoantibody may be involved in the pathogenesis of autoimmune bullous skin diseases.
Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke.
miR-22 represses osteoblast viability with ESR1 presenting a direct target and indirectly inactivating p38 MAPK/JNK signaling.
Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway.
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.
Quantitative iTRAQ LC-MS/MS reveals muscular proteome profiles of deep pressure ulcers.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2.
IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro.
Long Noncoding RNA LNC_000898 Alleviates Cardiomyocyte Apoptosis and Promotes Cardiac Repair After Myocardial Infarction Through Modulating the miR-375/PDK1 Axis.
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice.
The roles of SHANK1 in the development of colon cancer.
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
A novel antitumor dithiocarbamate compound inhibits the EGFR/AKT signaling pathway and induces apoptosis in esophageal cancer cells.
lncRNA KCNQ1OT1 knockdown inhibits colorectal cancer cell proliferation, migration and invasiveness via the PI3K/AKT pathway.
Vitamin D3 mediates miR-15a-5p inhibition of liver cancer cell proliferation via targeting E2F3.
ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.
Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway.
Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis.
PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.
(Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p.
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1.
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
The pro-inflammatory effect of NR4A3 in osteoarthritis.
LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway.
TRB3 interacts with ERK and JNK and contributes to the proliferation, apoptosis, and migration of lung adenocarcinoma cells.
LINC00365-SCGB2A1 axis inhibits the viability of breast cancer through targeting NF-κB signaling.
Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells.
Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.
Enhanced UV Resistance Role of Death Domain-Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint.
The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer.
Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p.
Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine.
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.
Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Propofol facilitates migration and invasion of oral squamous cell carcinoma cells by upregulating SNAI1 expression.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Novel diosgenin derivatives containing 1,3,4-oxadiazole/thiadiazole moieties as potential antitumor agents: Design, synthesis and cytotoxic evaluation.
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
A randomized phase 2 trial of apatinib vs observation as maintenance treatment following first-line induction chemotherapy in extensive- stage small cell lung cancer.
Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78.
FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.
N-glycosylation of uterine endometrium determines its receptivity.
Pizotifen inhibits the proliferation and invasion of gastric cancer cells.
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
lncRNA SNHG3 facilitates acute myeloid leukemia cell growth via the regulation of miR-758-3p/SRGN axis.
A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis.
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment.
Oxidative Stress and Endoplasmic Reticulum Stress Are Involved in the Protective Effect of Alpha Lipoic Acid Against Heat Damage in Chicken Testes.
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Hyperbaric Oxygen Ameliorated Acute Pancreatitis in Rats via the Mitochondrial Pathway.
Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Screening active components from Rubus amabilis for pancreatic β-cells protection.
Simvastatin protects high glucose-induced H9c2 cells from injury by inducing autophagy.
PS48 promotes in vitro maturation and developmental competence of porcine oocytes through activating PI3K/Akt signalling pathway.
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.
Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma.
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells.
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of Notch/Wnt/Hedgehog signaling pathways.
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury.
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis.
Synchrotron FTIR microspectroscopy revealed apoptosis-induced biomolecular changes of cholangiocarcinoma cells treated with ursolic acid.
Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway.
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN.
Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents.
Identification and functional analyses of a cell-death inhibitor encoded by guinea pig cytomegalovirus gp38.1 in cell culture and in animals.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells.
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Pharmacological activation of the p53 pathway by a new compound CYZ2017 exerts anti-tumor effects.
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Acetylcholine ameliorated TNF-α-induced primary trophoblast malfunction via muscarinic receptors†.
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study.
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis.
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Functional characterization of the long noncoding RNA MIR22HG as a tumour suppressor in cervical cancer by targeting IGF2BP2.
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats.
Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway.
Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration.
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.
Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit.
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes.
RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation.
A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy.
Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Upregulation of miRNA-9-5p Promotes Angiogenesis after Traumatic Brain Injury by Inhibiting Ptch-1.
Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis.
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer.
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy.
RETRACTED: MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway.
Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1α/MAPK signaling pathway.
MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4.
CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells.
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Estradiol-17β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1.
METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway.
Effects of photoelectric therapy on proliferation and apoptosis of scar cells by regulating the expression of microRNA-206 and its related mechanisms.
Novel nortriterpenoids with new skeletons and limonoids from the fruits of Evodia rutaecarpa and their bioactivities.
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Targeting BAX ubiquitin-binding sites reveals that BAX activation is essential for its ubiquitin-dependent degradation.
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8.
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21(WAF1/CIP1).
Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis.
Protocadherin 8 (PCDH8) Inhibits Proliferation, Migration, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma.
Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene.
Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.
Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes.
Bishonokiol A Induces Multiple Cell Death in Human Breast Cancer MCF-7 Cells.
Selenium ameliorates cadmium-induced mouse leydig TM3 cell apoptosis via inhibiting the ROS/JNK /c-jun signaling pathway.
MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer.
Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets.
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.
Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.
Cinobufagin Promotes Cell Cycle Arrest and Apoptosis to Block Human Esophageal Squamous Cell Carcinoma Cells Growth via the p73 Signalling Pathway.
Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
UFL1 Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4/NF-κB Pathway in Bovine Mammary Epithelial Cells.
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
MicroRNA-155 Promotes Myocardial Infarction-Induced Apoptosis by Targeting RNA-Binding Protein QKI.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence.
Polysaccharides of Fructus corni Improve Ovarian Function in Mice with Aging-Associated Perimenopause Symptoms.
Inhibition of LINC00994 represses malignant behaviors of pancreatic cancer cells: interacting with miR-765-3p/RUNX2 axis.
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.
Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
RRM2 is a potential prognostic biomarker with functional significance in glioma.
Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Treatment With 2-BFI Attenuated Spinal Cord Injury by Inhibiting Oxidative Stress and Neuronal Apoptosis via the Nrf2 Signaling Pathway.
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway.
Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT.
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ.
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells.
DHT deteriorates the progression of monocrotaline-induced pulmonary arterial hypertension: effects of endogenous and exogenous androgen.
Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol.
Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt/mTOR pathway and regulating BDNF and PTEN expression.
The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.
Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies.
TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.
BHLHE41 promotes U87 and U251 cell proliferation via ERK/cyclinD1 signaling pathway.
UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway.
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin.
A Novel Resveratrol-Arsenic Trioxide Combination Treatment Synergistically Induces Apoptosis of Adriamycin-Selected Drug-Resistant Leukemia K562 Cells.
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy.
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Prazosin inhibits the growth and mobility of osteosarcoma cells.
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
The protective role of microRNA-140-5p in synovial injury of rats with knee osteoarthritis via inactivating the TLR4/Myd88/NF-κB signaling pathway.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.
Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
A dual-enzymatically cross-linked injectable gelatin hydrogel loaded with BMSC improves neurological function recovery of traumatic brain injury in rats.
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis.
Cypermethrin exposure reduces the ovarian reserve by causing mitochondrial dysfunction in granulosa cells.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro.
Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways.
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
Linc01105 acts as an oncogene in the development of neuroblastoma.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer.
Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.
LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma.
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.
Protective effect of 4-Methoxy benzyl alcohol on the neurovascular unit after cerebral ischemia reperfusion injury.
Qingjie Fuzheng Granule attenuates 5-fluorouracil-induced intestinal mucosal damage.
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Induction of Chemerin on Autophagy and Apoptosis in Dairy Cow Mammary Epithelial Cells.
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro.
Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia.
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis.
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis.
Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice.
FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a O(6)-methylguanine-DNA methyltransferase-dependent manner.
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1.
MicroRNA-129-5p alleviates nerve injury and inflammatory response of Alzheimer's disease via downregulating SOX6.
Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway.
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Response of the maternal hypothalamus to cold stress during late pregnancy in rats.
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway.
Activation of Nrf2 signaling by Icariin protects against 6-OHDA-induced neurotoxicity.
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Establishment and characterization of a radiation-induced dermatitis rat model.
SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.
MicroRNA‑1 downregulation induced by carvedilol protects cardiomyocytes against apoptosis by targeting heat shock protein 60.
Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.
Alkaloids from Piper nigrum Synergistically Enhanced the Effect of Paclitaxel against Paclitaxel-Resistant Cervical Cancer Cells through the Downregulation of Mcl-1.
Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Myc and SOD2.
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax.
Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.
Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Toxicity Effects of Methylene Blue on Rat Intervertebral Disc Annulus Fibrosus Cells.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer.
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
The attenuation of HIV-1 Tat-induced neurotoxicity by Salvianic acid A and Danshen granule.
Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways.
Acid sphingomyelinase mediates the noise-induced liver disorder in mice.
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload.
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats.
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation.
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Echinacoside Alleviates Hypoxic-Ischemic Brain Injury in Neonatal Rat by Enhancing Antioxidant Capacity and Inhibiting Apoptosis.
p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro.
Amentoflavone Induces Apoptosis and Reduces Expression of Anti-apoptotic and Metastasis-associated Proteins in Bladder Cancer.
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
HBOA ameliorates CCl(4)-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway.
Melatonin attenuates cadmium-induced ovulatory dysfunction by suppressing endoplasmic reticulum stress and cell apoptosis.
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients.
Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma.
In vivo tracking on longer retention of transplanted myocardin gene-modified adipose-derived stem cells to improve erectile dysfunction in diabetic rats.
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload.
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism.
Selective Serotonin Reuptake Inhibitors Aggravate Depression-Associated Dry Eye Via Activating the NF-κB Pathway.
Anti-breast Cancer Activity of SPG-56 from Sweet Potato in MCF-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis.
Autophagy and Apoptosis Interact to Modulate T-2 Toxin-Induced Toxicity in Liver Cells.
Role of ZIP8 in regulation of cisplatin sensitivity through Bcl-2.
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT/NF-κB signaling pathway.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Ebselen protects rat hearts against myocardial ischemia-reperfusion injury.
Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates.
Exogenous Tetranectin Protects Against 1-Methyl-4-Phenylpyridine-Induced Neurotoxicity by Inhibiting Apoptosis and Autophagy Through Ribosomal Protein S6 Kinase Beta-1.
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA.
Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.
κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Protective Effect of Koumine, an Alkaloid from Gelsemium Sempervirens, on Injury Induced by H₂O₂ in IPEC-J2 Cells.
Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats.
Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice.
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Silence of S1 RNA binding domain 1 represses cell growth and promotes apoptosis in human non-small cell lung cancer cells.
Protective effect of miR-20a against hypoxia/reoxygenation treatment on cardiomyocytes cell viability and cell apoptosis by targeting TLR4 and inhibiting p38 MAPK/JNK signaling.
Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway.
Anti-tumour effects of red blood cell membrane-camouflaged black phosphorous quantum dots combined with chemotherapy and anti-inflammatory therapy.
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Molecular mechanism of miR-204 regulates proliferation, apoptosis and autophagy of cervical cancer cells by targeting ATF2.
Notch1 Drives the Formation and Proliferation of Intrahepatic Cholangiocarcinoma.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Inhibition of cyclin-dependent kinase 5 activity alleviates diabetes-related cognitive deficits.
Transarterial Infusion of iRGD-Modified ZrO(2) Nanoparticles with Lipiodol Improves the Tissue Distribution of Doxorubicin and Its Antitumor Efficacy.
Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway.
Effects of kojic acid on boar sperm quality and anti-bacterial activity during liquid preservation at 17 C.
Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro.
miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.
Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy.
The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5.
Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression.
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent.
PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Downregulation of TMPRSS4 Enhances Triple-Negative Breast Cancer Cell Radiosensitivity Through Cell Cycle and Cell Apoptosis Process Impairment.
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis.
Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect.
Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF.
RING finger protein 10 is a potential drug target for diabetic vascular complications.
E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1.
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.
Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression.
Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
[Effect of the chemoprotectant tempol on anti-tumor activity of cisplatin].
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration, and invasiveness, and promotes apoptosis in pancreatic cancer cells.
SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway.
Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle and apoptosis in mouse spermatogenic cells.
Protective effects of ethyl gallate on H(2)O(2)-induced mitochondrial dysfunction in PC12 cells.
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Heme oxygenase 1 regulates apoptosis induced by heat stress in bovine ovarian granulosa cells via the ERK1/2 pathway.
Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.
Treatment with metformin prevents myocardial ischemia-reperfusion injury via STEAP4 signaling pathway.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway.
Activation of the MAPK signaling pathway induces upregulation of pro-apoptotic proteins in the hippocampi of cold stressed adolescent mice.
Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism.
Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells.
Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.
Effects of 220 MHz Pulsed Modulated Radiofrequency Field on the Sperm Quality in Rats.
Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells.
Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure.
β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study.
Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells.
Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3.
High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway.
CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8.
Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.
Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway.
MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress.
MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Transcription factor KLF13 inhibits AKT activation and suppresses the growth of prostate carcinoma cells.
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ.
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.
Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.
Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells.
SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.
Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction.
Erythropoietin attenuates motor neuron programmed cell death in a burn animal model.
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis.
CD300A inhibits tumor cell growth by downregulating AKT phosphorylation in human glioblastoma multiforme.
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer.
Knockdown of HOXA transcript at the distal tip suppresses the growth and invasion and induces apoptosis of oral tongue squamous carcinoma cells.
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury.
Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation.
Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin-Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis, Endothelial Dysfunction, and Corporal Fibrosis.
Effects of Guanfu total base on Bcl-2 and Bax expression and correlation with atrial fibrillation.
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing K(ATP) channel.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy.
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Cattle Encephalon Glycoside and Ignotin Reduce Early Brain Injury and Cognitive Dysfunction after Subarachnoid Hemorrhage in Rats.
RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo.
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Dual effects of baicalin on osteoclast differentiation and bone resorption.
Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.
β-Bourbonene attenuates proliferation and induces apoptosis of prostate cancer cells.
Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis.
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin.
Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment.
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy.
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.
β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors.
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.
Activation of α7 nicotinic acetylcholine receptor alleviates Aβ(1-42)-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.
Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.
An E-selectin targeting and MMP-2-responsive dextran-curcumin polymeric prodrug for targeted therapy of acute kidney injury.
Role of capsaicin sensitive sensory nerves in ischemia reperfusion-induced acute kidney injury in rats.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells.
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway.
The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Supplementary choline attenuates olive oil lipid emulsion-induced enterocyte apoptosis through suppression of CELF1/AIF pathway.
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways.
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Potent hydrazone derivatives targeting esophageal cancer cells.
Chronic oxycodone induces axonal degeneration in rat brain.
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Krüppel-like factor 4 promotes c-Met amplification-mediated gefitinib resistance in non-small-cell lung cancer.
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.
Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
Hyperglycemia-induced Bcl-2/Bax-mediated apoptosis of Schwann cells via mTORC1/S6K1 inhibition in diabetic peripheral neuropathy.
SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.
Atrazine exposure improves the proliferation of H22 cells in vitro and in vivo.
Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum.
PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis.
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease.
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins.
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Protective Effect of Selenoprotein X Against Oxidative Stress-Induced Cell Apoptosis in Human Hepatocyte (LO2) Cells via the p38 Pathway.
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Molecular mechanisms of Ellis‑van Creveld gene variations in ventricular septal defect.
Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.
Tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and GluN2B overexpression in anterior cingulate cortex.
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Propranolol enhanced the anti-tumor effect of sunitinib by inhibiting proliferation and inducing G0/G1/S phase arrest in malignant melanoma.
Exosomes derived from imatinib-resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug-resistant trait by delivering miR-365.
Proteasome Inhibitor Carbobenzoxy-L-Leucyl-L-Leucyl-L-Leucinal (MG132) Enhances Therapeutic Effect of Paclitaxel on Breast Cancer by Inhibiting Nuclear Factor (NF)-κB Signaling.
Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4.
MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer.
Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration.
TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.
Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid.
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
Propofol protects against endotoxin-induced myocardial injury by inhibiting NF-κB-mediated inflammation.
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway.
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.
Blocking FGFR4 exerts distinct anti-tumorigenic effects in esophageal squamous cell carcinoma.
Mild Hypothermia Protects Renal Function in Ischemia-reperfusion Kidney: An Experimental Study in Mice.
Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway.
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
MAN1B1 is associated with poor prognosis and modulates proliferation and apoptosis in bladder cancer.
Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway.
Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.
Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.
Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy.
Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPARγ after experimental subarachnoid hemorrhage.
Canonical Transient Receptor Potential Channel 3 Contributes to Febrile Seizure Inducing Neuronal Cell Death and Neuroinflammation.
HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Improvement of vascular dysfunction by argirein through inhibiting endothelial cell apoptosis associated with ET-1/Nox4 signal pathway in diabetic rats.
Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Endoplasmic Reticulum Stress Facilitates the Survival and Proliferation of Nucleus Pulposus Cells in TNF-α Stimulus by Activating Unfolded Protein Response.
CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca(2+) -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Celecoxib enhances sensitivity to chemotherapy drugs of T-cell lymphoma.
Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells.
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
PSMB8 regulates glioma cell migration, proliferation, and apoptosis through modulating ERK1/2 and PI3K/AKT signaling pathways.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
miR-501 is upregulated in cervical cancer and promotes cell proliferation, migration and invasion by targeting CYLD.
COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage.
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy.
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.
Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia.
N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression.
N-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression.
Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model.
Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Relaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro.
MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS.
Downregulation of UBC9 promotes apoptosis of activated human LX-2 hepatic stellate cells by suppressing the canonical NF-κB signaling pathway.
The effect of cavernous nerve traction on erectile function in rats.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice.
Propofol alleviates hepatic ischemia/reperfusion injury via the activation of the Sirt1 pathway.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis.
Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis.
Visfatin induces the apoptosis of endothelial progenitor cells via the induction of pro-inflammatory mediators through the NF-κB pathway.
Puerarin increases the chemosensitivity of hepatocellular carcinoma cells.
Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways.
The natural product fucoidan ameliorates hepatic ischemia-reperfusion injury in mice.
In vitro anticancer activities of osthole against renal cell carcinoma cells.
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
Enhanced antitumor activity in A431 cells via encapsulation of 20(R)-ginsenoside Rg3 in PLGA nanoparticles.
14,15-EET Suppresses Neuronal Apoptosis in Ischemia-Reperfusion Through the Mitochondrial Pathway.
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.
An autophagic mechanism is involved in the 6-hydroxydopamine-induced neurotoxicity in vivo.
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats.
Cysteine-rich buccal gland protein suppressed the proliferation, migration and invasion of hela cells through akt pathway.
Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide.
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations.
Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression.
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
Correlation between miR-19a inhibition and radiosensitivity in SiHa cervical cancer cells.
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level.
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin.
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
15-Deoxy-Δ(12,14)-prostaglandin J(2) alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy.
Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.
Clinical Significance and Tumor-Suppressive Function of miR-516b in Nonsmall Cell Lung Cancer.
The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.
Synthesis, characterization, and radioprotective activity of α,β-unsaturated aryl sulfone analogs and their Tempol conjugates.
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
The Anticonvulsant and Neuroprotective Effects of Oxysophocarpine on Pilocarpine-Induced Convulsions in Adult Male Mice.
Mitochondrial Dysfunction and Ca(2+) Overload in Injured Sertoli Cells Exposed to Bisphenol A.
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.
Beneficial effects of Lycium barbarum polysaccharide on spermatogenesis by improving antioxidant activity and inhibiting apoptosis in streptozotocin-induced diabetic male mice.
Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer.
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.
Acid sphingomyelinase/ceramide regulates carotid intima-media thickness in simulated weightless rats.
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
Charge reversible calcium phosphate lipid hybrid nanoparticle for siRNA delivery.
MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma.
Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway.
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-β1/Smad signaling pathway.
In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells.
Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.
Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells.
Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury.
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Hypertonic saline infusion suppresses apoptosis of hippocampal cells in a rat model of cardiopulmonary resuscitation.
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.
Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury.
Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction.
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells.
Triggering of apoptosis in osteosarcoma cells by graphene/single-walled carbon nanotube hybrids via the ROS-mediated mitochondrial pathway.
Targeted breast cancer therapy by harnessing the inherent blood group antigen immune system.
Propylene Glycol Alginate Sodium Sulfate Alleviates Cerulein-Induced Acute Pancreatitis by Modulating the MEK/ERK Pathway in Mice.
Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis.
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Doxepin Mitigates Noise-induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway.
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Autologous Adipose-Derived Stem Cells Reduce Burn-Induced Neuropathic Pain in a Rat Model.
BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cells.
The Effect of Selenium on the Cd-Induced Apoptosis via NO-Mediated Mitochondrial Apoptosis Pathway in Chicken Liver.
Treatment mechanism of matrine in combination with irinotecan for colon cancer.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fas and caspase-3.
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats.
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Epigallocatechin-3-gallate inhibits H(2)O(2)-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis.
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.
Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53.
The mir-675-5p regulates the progression and development of pancreatic cancer via the UBQLN1-ZEB1-mir200 axis.
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Lobaplatin for the treatment of SK-MES-1 lung squamous cell line in vitro and in vivo.
Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.
Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis.
ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin.
Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway.
Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK.
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells.
OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Models.
Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction.
Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model.
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP.
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
47kDa isoform of Annexin A7 affecting the apoptosis of mouse hepatocarcinoma cells line.
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma.
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance.
Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma.
Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Triazole fungicide tebuconazole disrupts human placental trophoblast cell functions.
The role of RhoA in vulvar squamous cell carcinoma: a carcinogenesis, progression, and target therapy marker.
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
β-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-κB Signaling Pathway.
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Suppression of SOX18 by siRNA inhibits cell growth and invasion of breast cancer cells.
Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.
Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats.
Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase.
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway.
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
The Role of the Y Box Binding Protein 1 C-Terminal Domain in Vascular Endothelial Cell Proliferation, Apoptosis, and Angiogenesis.
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer.
Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Effects of induced pluripotent stem cells-derived conditioned medium on the proliferation and anti-apoptosis of human adipose-derived stem cells.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.
Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α.
KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Naringin protects against lipopolysaccharide-induced cardiac injury in mice.
Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells.
Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats.
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
PACE4 regulates apoptosis in human pancreatic cancer Panc‑1 cells via the mitochondrial signaling pathway.
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.
Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction.
Level of circulated microRNA-421 in gastric carcinoma and related mechanisms.
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord.
A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.
Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells.
Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells.
Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice.
Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus.
Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death.
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
A Neuroprotective Sericin Hydrogel As an Effective Neuronal Cell Carrier for the Repair of Ischemic Stroke.
Progranulin protects against renal ischemia/reperfusion injury in mice.
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis.
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway.
Enantioselective apoptosis induced by individual isomers of bifenthrin in Hep G2 cells.
Knockdown of CkrL by shRNA deteriorates hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis and survival inhibition Via Bax and downregulation of P-Erk1/2.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Optimization of intrinsic and extrinsic tendon healing through controllable water-soluble mitomycin-C release from electrospun fibers by mediating adhesion-related gene expression.
Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Potent effects of dioscin against liver fibrosis.
Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.
Lycium barbarum polysaccharides protect human lens epithelial cells against oxidative stress-induced apoptosis and senescence.
PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.
The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways.
14-Thienyl methylene matrine (YYJ18), the derivative from matrine, induces apoptosis of human nasopharyngeal carcinoma cells by targeting MAPK and PI3K/Akt pathways in vitro.
The mitochondrial thioredoxin is required for liver development in zebrafish.
RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma.
Lipoxin A4 methyl ester ameliorates cognitive deficits induced by chronic cerebral hypoperfusion through activating ERK/Nrf2 signaling pathway in rats.
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats.
Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
A caspase-dependent pathway is involved in Wnt/β-catenin signaling promoted apoptosis in Bacillus Calmette-Guerin infected RAW264.7 macrophages.
Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of lewis cells via RAGE/TLR4-dependent signal pathways.
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.
Daphnoretin-induced apoptosis in HeLa cells: a possible mitochondria-dependent pathway.
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells.
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
The protective effect of Cold-inducible RNA-binding protein (CIRP) on testicular torsion/detorsion: an experimental study in mice.
Administration of cathepsin B inhibitor CA-074Me reduces inflammation and apoptosis in polymyositis.
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
Oxysophoridine protects against focal cerebral ischemic injury by inhibiting oxidative stress and apoptosis in mice.
Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer.
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.
Neuroprotective effect of Danshensu derivatives as anti-ischaemia agents on SH-SY5Y cells and rat brain.
The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.
Alantolactone induces activation of apoptosis in human hepatoma cells.
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism.
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.
The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion.
Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.
Involvement of GPR12 in the regulation of cell proliferation and survival.
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes.
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure.
Wang Y, Wang Y, Cui Y, He Y, Yang Y, Zhou W, Liu L, Wang H, Liu M, Wei Y, Huang Z, Wei X, Mao X
International journal of biological sciences 2026;22(4):1793-1806
International journal of biological sciences 2026;22(4):1793-1806
AVN944 Elicits Apoptotic Responses and Impedes Tumorigenic Potential in Ewing's Sarcoma Cells.
Lim H, Lee S, Kim G, Lee EJ, Kim J
International journal of biological sciences 2026;22(2):529-552
International journal of biological sciences 2026;22(2):529-552
Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity.
Chen J, Zhang Q, Huang J, He H, Bai Y, An Y, Hao M, Zhao W, Li W, Feng S, Yang S, Liao J, Wong YK, Dai L, Du Q, Luo P, Wang J
International journal of biological sciences 2026;22(1):481-499
International journal of biological sciences 2026;22(1):481-499
Knockdown of miR-21-5P targets and regulates PDCD4-induced apoptosis in ovarian granulosa cells and ameliorates in sulin resistance in polycystic ovary syndrom.
He H, Ning P, Chen X, Lin J
PloS one 2026;21(3):e0343735
PloS one 2026;21(3):e0343735
Exosome encapsulated albumin nanoparticles target delivery of DBET6 as a treatment for triple-negative breast cancer.
Yu H, Zhao J, Wu D, Yuan H
PloS one 2026;21(1):e0335890
PloS one 2026;21(1):e0335890
Glioma Cell Membrane-Coated CaCO(3) Nanoparticles for Localized Postoperative Chemo-Calcium Overload Therapy to Prevent Glioma Recurrence.
Hou S, Zhang C, Wang Y, Li X, Wang Z, Wang J, Yang M, Liang Z, Lin N
International journal of nanomedicine 2026;21:578002
International journal of nanomedicine 2026;21:578002
CD44 Receptor-Mediated Delivery of ROS/pH Dual-Sensitive Nanoparticles Based on Poly(Ethylene Glycol)-b-Poly(Doxorubicin)-b-Hyaluronic Acid Copolymer.
Kim TH, Kim W, Kim WJ, Park JS, Park SY, Jeong YL, Kim HJ, Kim SJ
International journal of nanomedicine 2026;21:569702
International journal of nanomedicine 2026;21:569702
Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4(+) T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
Li Y, Kong X, Cai H, Tian W, Ren Y, Xu F, Peng S, Niu J, Xin G, Wang J, Zhang H, Wang L
Mediators of inflammation 2026;2026(1):e2877539
Mediators of inflammation 2026;2026(1):e2877539
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Xie F, Feng J, Li K, Chen Y, Han L, Wu Y
Mediators of inflammation 2026;2026:5524066
Mediators of inflammation 2026;2026:5524066
Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
Jin W, Wu Y, Cheng X, Pan Y, He L, Xu Y, Xu J, Zhang X
Mediators of inflammation 2026;2026:5486971
Mediators of inflammation 2026;2026:5486971
Obacunone Promotes Functional Recovery After Spinal Cord Injury by Attenuating Neuroinflammation by Targeting the TLR4/MyD88/p38 MAPK Pathway.
Kuang W, Zhang M, Zhang J, Huang H, Chen Q, Yu C, Peng B, Sun W, Lin J, Cheng J, Zhu L
Drug design, development and therapy 2026;20:577707
Drug design, development and therapy 2026;20:577707
Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
Fan J, Liu Y, Zheng C, Liu J, Liu W, Geng R, Zhao A, Wang Y, Wang R, Qi Z
Journal of inflammation research 2026;19:580534
Journal of inflammation research 2026;19:580534
Combined Treatment with Shuyu Pills and Everolimus Suppresses Triple-Negative Breast Cancer Growth via the PI3K/AKT/mTOR Pathway.
Zhao J, Luo X, Li H, Cheng Y, Lin X, Xie S
Breast cancer (Dove Medical Press) 2026;18:580570
Breast cancer (Dove Medical Press) 2026;18:580570
TIGIT impairs NK cell antifibrotic activity through the IFNγ-IFI30 axis in schistosomiasis-induced liver fibrosis.
Peng H, Zhang J, Zhang X, Zhou H, Cui L, Xu F, Jiang T, Yin J, Hu Y, Shen Y, Lu S, Cao J
Frontiers in immunology 2026;17:1766930
Frontiers in immunology 2026;17:1766930
Dietary dihydroquercetin alleviates age-related cognitive impairment in association with modulation of apoptosis and pyroptosis pathways.
Zeng Y, Xu D, Li X, Jiang Q, Liang S
Frontiers in pharmacology 2026;17:1744898
Frontiers in pharmacology 2026;17:1744898
SLC31A1 knockdown mitigates post-MI heart failure via regulation of copper metabolism.
Wei Q, Zhou H, Sun J, Qin L
Frontiers in immunology 2026;17:1707203
Frontiers in immunology 2026;17:1707203
Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway.
Zhang L, Gong Y, Chen J, Li M, Wang X, Wang W, Ding Q, Li Y
Frontiers in immunology 2026;17:1561666
Frontiers in immunology 2026;17:1561666
Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2.
Wang X, Li J, Jiang C, Zhang C, Yuan L, Zhang T, Liu Y, Ma S, Kang P, Li D, Guan X, Chen J, Jia W
Theranostics 2026;16(6):3032-3049
Theranostics 2026;16(6):3032-3049
Electroacupuncture reduces calcium influx and inhibits endoplasmic reticulum stress by inhibiting the PKCδ-TRPA1 pathway to promote motor function recovery after spinal cord injury.
Zhang Y, Liang C, Huang Z, Hu Y, Mo Y, Ning S, Li Z, Wu Y, Zhang J, Li X, Wang Z
Burns & trauma 2026;14:tkaf066
Burns & trauma 2026;14:tkaf066
Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes.
Zhang Q, Zhao N, Wei S, Lu M, Chen K
Frontiers in cardiovascular medicine 2026;13:1670472
Frontiers in cardiovascular medicine 2026;13:1670472
Injectable Cu(2+) loaded rhein hydrogel for cross-amplifying osteosarcoma apoptosis and cuproptosis epitranscriptomically.
Zhu J, Zhou T, Tang X, Gao Y, Teng Q, Zhang Y, Lv Z, Chen X, Zou J, Shi H
Biomaterials 2026 Sep;332:124170
Biomaterials 2026 Sep;332:124170
Pressurized intraperitoneal cold atmospheric plasma as a novel therapeutic strategy for peritoneal metastatic carcinoma.
Min T, Zhang B, Ren K, Ma Y, Ma R, Peng Y, Wang X, Xie X, Deng X, Liu Y, Nan Y, Tong S, Zhang Y, Zhu K, Wei Y, Hao N, Liang C, Wang W, Zhang G, Dang C, Sun T, Zhang H
Journal of advanced research 2026 May;83:991-1004
Journal of advanced research 2026 May;83:991-1004
The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study.
Li Y, Que J, Xia Y, Wang L, Zhang P, Cheng Z, Gao B
Translational oncology 2026 May;67:102732
Translational oncology 2026 May;67:102732
PLOD2 Promotes Cutaneous Squamous Cell Carcinoma Progression in Association With STAT3-Related ERK and AKT Pathways.
Xian N, Wang Z, Wang B, Wang X, Zheng Y
Molecular carcinogenesis 2026 May;65(5):615-629
Molecular carcinogenesis 2026 May;65(5):615-629
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
miR-329-3p derived from mast cells-exosomes exacerbates intestinal ischemia-reperfusion injury by targeting ATG10 to regulate autophagy.
Liang Y, Sheng R, Deng H, Huang D, Xu K, Wang Y, Liu D
International journal of biological macromolecules 2026 May;361:152091
International journal of biological macromolecules 2026 May;361:152091
VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway.
Yang X, Fang W, Chang R, Ma L, Chen X, Li Y
Molecular medicine reports 2026 May;33(5)
Molecular medicine reports 2026 May;33(5)
Near-infrared photobiomodulation can alleviate chemotherapy-induced peripheral neuropathy-associated sensory abnormalities.
Ren Z, Fan H, Chen Y, Chang M, Jiang S, Liu G, Guo Y, Wang Z, Gu L, He D, Yang L
Journal of photochemistry and photobiology. B, Biology 2026 May;278:113411
Journal of photochemistry and photobiology. B, Biology 2026 May;278:113411
m⁶A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop.
Yi Q, Zhong K, Chen Z, Ouyang X, Zhu W, Liang L, Zhong J
Molecular immunology 2026 May;193:50-67
Molecular immunology 2026 May;193:50-67
Echinacoside regulates the IRE1/XBP1 signaling pathway through HSP72 to reduce endoplasmic reticulum stress and improve diabetic kidney disease.
Geng R, Ma C, Wen L, Dai W, Liu J, Yang J, Hu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158062
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158062
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.
You H, Li LG, Xiao CY, Wang X, Kong C, Leng F, Bai XF, Han N, Li TF, Wang MF
Molecular pharmaceutics 2026 May 4;23(5):3131-3145
Molecular pharmaceutics 2026 May 4;23(5):3131-3145
Exosomes derived from Bcl-2-engineered iPSC-cardiomyocytes mitigate aortic valve calcification and inhibit cardiomyocyte apoptosis.
Li N, Xiao R, Zhu L, Cai L, Zhang Z, Sun L, Shi H, Ye H, Shao G, Gao J
International journal of pharmaceutics 2026 May 20;697:126877
International journal of pharmaceutics 2026 May 20;697:126877
Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis.
Yan P, Kyaw ZO, Wang X, Li N, Xu Y, Gao S, Huan C
Journal of virology 2026 May 19;100(5):e0011726
Journal of virology 2026 May 19;100(5):e0011726
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis.
Hu N, Gao Y, Fan R, Xue Y, Fang S, Wu S, Luo T, Hu L, Zhang D, Zheng L
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:128007
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:128007
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
Taohong Siwu decoction and its components regulate the M1/M2 polarization of macrophages to alleviate inflammatory injury in sepsis via the RAGE.
Han X, Pang M, Hu C, Li Y, Xu T, Xu H, Ye H, Xie L, Shen A, Liu B, Zhang G, Zhou Y
Journal of ethnopharmacology 2026 May 10;362:121366
Journal of ethnopharmacology 2026 May 10;362:121366
Modified Banxia Xiexin Decoction promotes mitochondrial fission in colon cancer cells by inhibiting the CHD6-TMEM65 axis.
Wu Z, Xiao C, Li X, You F, Su L
Journal of ethnopharmacology 2026 May 10;362:121323
Journal of ethnopharmacology 2026 May 10;362:121323
The C3-C3aR axis drives rotenone-induced cognitive damage via synaptic engulfment, dark microglia and PANoptosis.
Liu J, Hou L, Ma Y, Tian L, Hong JS, Zhao J, Wang Q
Redox biology 2026 Mar;90:104062
Redox biology 2026 Mar;90:104062
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Zhang Y, Han Y, Li S, Shan R, Lin L, Gu Z, Wang R, Chen Y, Xiao J, An F, Hu C, He C
Redox biology 2026 Mar;90:103993
Redox biology 2026 Mar;90:103993
Therapeutic effect of oleanolic acid on hyperthyroid rats through TLR4/NF-κB pathway.
Zhong J, Zhou X, Zhang J, Zou B
Xenobiotica; the fate of foreign compounds in biological systems 2026 Mar;56(3):228-239
Xenobiotica; the fate of foreign compounds in biological systems 2026 Mar;56(3):228-239
Sulforaphane Attenuates Methamphetamine-Induced Neurotoxicity via Activation of the PI3K/AKT Pathway.
Li S, Zhang J, Li X, Zhang G, Ren L, Yang C, Niu S, Cui W, Wang Y, Yan J
Journal of biochemical and molecular toxicology 2026 Mar;40(3):e70769
Journal of biochemical and molecular toxicology 2026 Mar;40(3):e70769
BNIP3L-Mediated Mitophagy Inhibits Cadmium-Induced Apoptosis in the Rat Cerebral Cortex.
Wang L, Zhang Q, Hou Y, Miao W, Wen S
Journal of biochemical and molecular toxicology 2026 Mar;40(3):e70747
Journal of biochemical and molecular toxicology 2026 Mar;40(3):e70747
Lithospermic Acid Improves Doxorubicin-Induced Cardiomyopathy Through Sirtuin-3-Mediated Deacetylation of p53.
Zhao Y, Xu T, Ye C, Zhang K, Heng X, Huang S, Chen Y, Guo Y, Shao S, Wen Z, Shao C, Lu X, Sun N, Yang H
Phytotherapy research : PTR 2026 Mar;40(3):965-985
Phytotherapy research : PTR 2026 Mar;40(3):965-985
CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis.
Sun L, Shi S, Wang W, Zhang Y
The American journal of the medical sciences 2026 Mar;371(3):286-294
The American journal of the medical sciences 2026 Mar;371(3):286-294
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Dong D, Sun Y, Sui Q, Zhao Z, Ma H, Li K, Yu X
Inflammopharmacology 2026 Mar;34(3):1973-1990
Inflammopharmacology 2026 Mar;34(3):1973-1990
Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.
Xu H, Mi H, Cheng R, Gui T, Hu F, Yang Y, Cheng J, Xue Q
CNS neuroscience & therapeutics 2026 Mar;32(3):e70815
CNS neuroscience & therapeutics 2026 Mar;32(3):e70815
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Li W, Zhou D, Ji Y, Yang M, Yang Y, Dao M, He X, Jin X
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Ji K, Wei H, Wang R, Wu Y, Li C, Gao H, Zhao L
Aging cell 2026 Mar;25(3):e70423
Aging cell 2026 Mar;25(3):e70423
TPPU alleviates hepatic ischemia-reperfusion injury by regulating macrophage polarization.
Pan H, Lu J, Han T, Liang H, Zhang W, Hou W, Shen Z
Biochemical pharmacology 2026 Mar;245:117657
Biochemical pharmacology 2026 Mar;245:117657
Cell-free supernatant of Clostridium butyricum induces mitochondrial apoptosis and suppresses NF-κB pathway in colorectal cancer cells.
Liu M, Liu S, Xie W, Li G, Deng T
Immunobiology 2026 Mar;231(2):153172
Immunobiology 2026 Mar;231(2):153172
Vanadyl Acetylacetonate and Berberine Synergistically Ameliorate Diabetes-induced Vascular Dysfunction and Reduce Endothelial Toxicity through ERK and Akt Regulation.
Sun J, Shi N, Zhang X, Dong J, Zhao L, Wei T, Guan C, Li X, Yu X, Hou C
Biological trace element research 2026 Mar;204(3):1678-1692
Biological trace element research 2026 Mar;204(3):1678-1692
Alginate Oligosaccharide Alleviates Salmonella Typhimurium-Induced Liver Injury by Regulating Oxidative Stress, Apoptosis, and Inflammatory Signaling Pathway.
Liu Y, Zhang X, Ge Y, Liu H, Chen Y, Yang Y, Yang Y, Wu Z
Probiotics and antimicrobial proteins 2026 Mar;18(2):2699-2715
Probiotics and antimicrobial proteins 2026 Mar;18(2):2699-2715
A triple combination strategy for nasopharyngeal carcinoma: Aptamer-guided liposomal chemotherapy, engineered NK cells, and Fc-enhanced PD-L1 antibody therapy.
Yao C, Wang L, Liu W, Shi N, Liao Z, Fu Y, Ouyang J, Lei X, Huang Q, Li S, Zhouyang Y, Zhao P, Wang J, Xu H, Zhou W, Jiang X, Gao X, Ren C, Luo L
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1584-1604
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1584-1604
Qiangjing Tablets modulate oxidative stress and endoplasmic reticulum stress through the PI3K/Akt/NRF-2 signaling axis and regulate gut microbiota in ornidazole-induced asthenozoospermia rats.
Li G, Gao D, Chang D, Zhang P, Ma Z, Chen D, Gao X, Ye N, Huang X, You Y
Journal of traditional and complementary medicine 2026 Mar;16(2):178-190
Journal of traditional and complementary medicine 2026 Mar;16(2):178-190
Targeted Degradation of eEF2K by a Structure-Guided PROTAC Strategy for the Treatment of Triple-Negative Breast Cancer.
Cao S, Zhong C, Jiang S, Li Y, Xi Y, Xiao M, Jiang T, Wan X, Chen Z, Yu X, Cheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e20863
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e20863
Gallium-Doped MXene Nanozymes Protect Liver Through Multi-Death Pathway Blockade and Hepatocyte Regeneration.
Cai X, Deng J, Wang L, Su J, Xian D, Yan Y, Yang X, Wu C, Peng T, Ding Y, Quan G, Wang W, Zhou M, Lu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e09079
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e09079
Study on the Mechanism of Paeoniflorin, an Active Component of Paeonia lactiflora Pall., in Improving Skin Pigmentation by Inhibiting the TNF-α Signaling Pathway.
Yin K, Wang S, Wang W, Liu T, Qi D, Wang W, Rashed MMA, Duan H, He C, Zhang M, Liu H, Zhai K
Pharmaceuticals (Basel, Switzerland) 2026 Mar 9;19(3)
Pharmaceuticals (Basel, Switzerland) 2026 Mar 9;19(3)
Study on the Role of the AMPK/PGC-1α Pathway in Cold-Induced Vascular Endothelial Cell Apoptosis and Uterine Damage.
Bai S, La X, Yang Y, Li Y, Wang D, Ren Y, Fang H, Li X, Song X, Cheng X, Xu D
Biology 2026 Mar 6;15(5)
Biology 2026 Mar 6;15(5)
Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing.
Deng X, Ren K, Min T, Ma Y, Peng Y, Wang S, Zhang B, Xie X, Nan Y, Tong S, Liu Y, Zhang Y, Li K, Wang W, Hao N, Zhang G, Dang C, Sun T, Zhu K, Zhang H
Journal of advanced research 2026 Mar 6;
Journal of advanced research 2026 Mar 6;
A novel rhein derivative Y01 inhibits hepatocellular carcinoma by inducing apoptosis through regulating PI3K/AKT/mTOR pathway.
Ji M, Li M, Zhou Z, Yang L, Ran D, Yang T, Yang L, Tian W, Yang P
The Journal of pharmacy and pharmacology 2026 Mar 5;78(3)
The Journal of pharmacy and pharmacology 2026 Mar 5;78(3)
Citronellol potentiates sunitinib efficacy in renal cell carcinoma by targeting JAK2/STAT3 signaling pathway.
Sun Z, Chen Z, Cai Y, Yin G, Song Y, Jia X, Liu M
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 5;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 5;
Yixinshu attenuates myocardial infarction via SHP1/JAK2/STAT3-mediated regulation of mitochondrial function and apoptosis.
Wang X, Wang X, Liu Y, Cui Y, Chen K, Wu H, Zhang M, Liao M, Fu L, Shen X
Chinese medicine 2026 Mar 4;21(1)
Chinese medicine 2026 Mar 4;21(1)
Phellopterin Inhibits Inflammation and Relieves Cartilage Degradation by Suppressing MAPK Signaling in Osteoarthritis.
Sun C, Wang Y, Zhang K, Liu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71698
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71698
CSF1 regulates inflammation and apoptosis in intervertebral disc degeneration.
Zhang F, Wu W, Yuan Y, Wang Y, Zhang W
Scientific reports 2026 Mar 30;16(1)
Scientific reports 2026 Mar 30;16(1)
DUSP4 mitigates doxorubicin-induced cardiotoxicity via the p38 MAPK/MK2 signaling pathway.
Deng L, Zha Y, Zhu C, Li Y, He M, Zhang S
Biochimica et biophysica acta. Molecular cell research 2026 Mar 29;1873(5):120141
Biochimica et biophysica acta. Molecular cell research 2026 Mar 29;1873(5):120141
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis.
Yuan S, Wei N, Ma W, Hu M, Zhang B, Gao L, Gao C, Yang X, Meng Y, Liu J, Cui Y
Andrology 2026 Mar 27;
Andrology 2026 Mar 27;
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2.
Zhan Z, Jiang Y, Chen S, Yang Q, Pan G, Liu Y, Fang W, Chen R, Tang L, Lin C
Journal of ethnopharmacology 2026 Mar 25;359:121067
Journal of ethnopharmacology 2026 Mar 25;359:121067
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis.
Zhu W, Cui Y, Zhou Y, Zheng Y, Huang L, Jin L, Zhang Q, Chen P, Lin M, Ye J, Xiong Y, Huh JY, Hu X, Li X, Luo W, Liang G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 25;:e21164
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 25;:e21164
Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
Wang W, Zhou H, Tan S, Qin D, Wang S, Xu C, Lei X, Li W, Wang L, Fu S, Jia S, Xu B, Zha J
Cell death & disease 2026 Mar 23;17(1)
Cell death & disease 2026 Mar 23;17(1)
Ginsenoside Suppresses Triple-Negative Breast Cancer Growth and Synergizes With Programmed Cell Death Protein 1 (PD-1) Immunotherapy Through Gut Microbiota and Metabolic Regulation.
Luo N, Li X, Hu Y, Guo L, Zhang K
Phytotherapy research : PTR 2026 Mar 22;
Phytotherapy research : PTR 2026 Mar 22;
A novel chassis for high-quality recombinant protein expression: apoptosis pathway engineering via multi-gene knockout and efficacy improvement of CHO cells.
Wu Y, Cao Y, Guo Z, Ma Y, Zan X, Gu X, Zhang F, Chai C, Nui R, Shang Q, Wang W
Journal of biological engineering 2026 Mar 21;20(1)
Journal of biological engineering 2026 Mar 21;20(1)
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
SGK1 Is Upregulated in Retained Placenta and Mediates Estradiol Effects in Bovine Endometrial Cells.
Wang R, Wei M, Niu W, Chen J, Nan J, Zhang Y, Zhao X, Wang Q
Cells 2026 Mar 20;15(6)
Cells 2026 Mar 20;15(6)
LncRNA H19 overexpression protects against acute kidney injury after cardiopulmonary bypass via activating Pink1/Parkin-mediated mitophagy.
Zhang M, Liu M, Wang T, Du Y, Chen Y, Bai Y, Zhang Y, Xue D, Ji B, Wang G
Chinese medical journal 2026 Mar 20;139(6):880-890
Chinese medical journal 2026 Mar 20;139(6):880-890
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling.
Yu Z, Kuang J, Wan X, Liang C, Wu F, Shu Z, Liang W, Wan X, Gong J
In vitro cellular & developmental biology. Animal 2026 Mar 20;
In vitro cellular & developmental biology. Animal 2026 Mar 20;
PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
Lin S, Wu B, Sun S, Sun T
International journal of molecular sciences 2026 Mar 2;27(5)
International journal of molecular sciences 2026 Mar 2;27(5)
FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Li X, Zuo S, Zhang Y, Liu Z, Shen N, Ma Q, Sun M, Zhang B, Li M, Huang H, Gao M, Huang Z, Zhao H, Chen Y, Gao F, Fan W, Zhang Z, Hu Y, An Y, Li S, Liu M, Liu Y, Liu Y, Li C, Zhang Y, Li Y, Cao W, Wang F, Song Y, Xu L, Bian Z, Li W
Cell reports. Medicine 2026 Mar 17;7(3):102686
Cell reports. Medicine 2026 Mar 17;7(3):102686
Comprehensively exploring the roles of MAGEA1 in cryptorchidism and its related transcription factor regulatory network.
Chen J, Shen D, Kong J, Zhang Y, Ge W, Xian H
Journal of molecular histology 2026 Mar 17;57(2)
Journal of molecular histology 2026 Mar 17;57(2)
Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.
Li F, Li H, Jia Y, Ou L, Fang Y, Pan L, Liu H, Ning B
Journal of translational medicine 2026 Mar 17;24(1)
Journal of translational medicine 2026 Mar 17;24(1)
M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation.
Zhang MY, Ji DN, Qi WY, Wang S, Dai CY, Xu FY, Dong Z, Xiong C, Zhang BW, Wang Y, Guo XF, Zhang B, Cheng WZ, Zhang XY, Jin SD, Guan XX, Hong H, Zhou T, Li SF, Zhang R, Sun LH, Xuan LN, Jiang Y, Yang BF, Xu CQ
Signal transduction and targeted therapy 2026 Mar 17;11(1)
Signal transduction and targeted therapy 2026 Mar 17;11(1)
Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence.
Xu Y, Li X, Munoz A, Jiang L, Huang L, Zhou Y, Zhu L, Yang Y
Animal models and experimental medicine 2026 Mar 17;
Animal models and experimental medicine 2026 Mar 17;
Study on the effects and mechanisms of M2 macrophages on PYCR1-promoted biological behavior of hepatocellular carcinoma cells.
Jin X, Hou Y, Guo J, Zhang J, Wu W
Scientific reports 2026 Mar 16;16(1)
Scientific reports 2026 Mar 16;16(1)
Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation.
Liu J, Duan Y, Xiao Q, Deng S, Li A, Wu D, Wu J, Liu C, Yi H, Wang M, Shu G, Yin G
Cell death and differentiation 2026 Mar 14;
Cell death and differentiation 2026 Mar 14;
Enzalutamide effectively inhibits the growth of meningiomas via p21-dependent senescence induction.
Trasaktaweesakul T, Asavaritikrai P, Khuansonthi P, Jaturutthaweechot P, Naewwan N, Talabnin K, Talabnin C
Molecular biology reports 2026 Mar 13;53(1)
Molecular biology reports 2026 Mar 13;53(1)
Maresin-1 Alleviates Sepsis-Induced Liver Injury by Regulating Apoptosis and Autophagy via Activation of the PI3K/Akt Signaling Pathway in Mice.
Wang H, Sun M, Fan H
Current issues in molecular biology 2026 Mar 13;48(3)
Current issues in molecular biology 2026 Mar 13;48(3)
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
Zheng H, Tian S, Wu L, Jia G, Xiao Y, Yu X, Zuo Q, Zhou R, Min J, Wu Q, Xie H, Luo Q, Wu W
The journal of headache and pain 2026 Mar 11;27(1)
The journal of headache and pain 2026 Mar 11;27(1)
Dietary semen cuscuta improves laying performance by stabilizing mitochondria-associated membranes (MAMs) and inhibiting granulosa cell apoptosis in laying hens.
Si C, Chen Y, Liu L, Liu S, Zhang Z, Guo L, Zhao M, Chen Y, Shi Y, Shi W, Ma S
Poultry science 2026 Mar 10;105(6):106749
Poultry science 2026 Mar 10;105(6):106749
circKANSL1 promotes immature porcine Sertoli cell growth via recruiting the Vimentin to enhance its parental gene KANSL1 expression.
Yan S, Weng B, Xiang J, Chen B, Ran M
Theriogenology 2026 Mar 1;252:117772
Theriogenology 2026 Mar 1;252:117772
Butyrate protects against Klebsiella pneumoniae-induced oxidative stress in alveolar macrophages via p62-Keap1-Nrf2 pathway.
Meng B, Li H, Tang M, Zhu J, Yao R, Xu Y, Zhang Q, Zhu R, Guo Y, Xu Y, Shu Y, Yu L, Li Y, Yang Y, Liu Y, Wu T, Li J
Redox biology 2026 Jun;93:104156
Redox biology 2026 Jun;93:104156
Mesenchymal Stem Cell-Lysate Sustained-Release Nano-Hydrogel Alleviates Spinal Cord Injury by Inhibiting Ferroptosis and Mitochondrial Intrinsic Apoptosis.
Sun ML, Wu H, Liu SY, Jiang CL, Zhou H, Hou A
International dental journal 2026 Jun;76(3):109557
International dental journal 2026 Jun;76(3):109557
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Fu Z, Li M, Dong K, Feng J, Wang W
International journal of oncology 2026 Jun;68(6)
International journal of oncology 2026 Jun;68(6)
Silencing of MAT2A inhibits gastric cancer cell proliferation, migration, and invasion through activation of the p53 pathway.
Du Y, Li KX, You LB, Zhang JN, Chen Q, Xiong H, Wang JF, Zhou ZY, Zhang S
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Jun;28(6):2183-2197
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Jun;28(6):2183-2197
Skin commensal Cutibacterium acnes alleviates UVB-induced solar dermatitis via ceramide-mediated TLR4-MyD88-NF-κB.
Ma Y, Ni Z, Zhu L, Yang J, Zhang Y, Liu W, Wang R, Sun Y, Liu J, Zhang P, Yu L, Huangfu C, Gao Y, Zhou W
Free radical biology & medicine 2026 Jun;249:76-88
Free radical biology & medicine 2026 Jun;249:76-88
OXCT1-induced succinylation at K81 shields HADH from HSPA8-Mediated degradation in alveolar epithelial cells to attenuate lung ischemia-reperfusion injury.
Li J, Guan H, Miao P, Han Z, Ding C, Jin Z, Wei L
Free radical biology & medicine 2026 Jun;249:43-59
Free radical biology & medicine 2026 Jun;249:43-59
TIMM23-ERAL1 Axis: A novel regulator of mitochondrial apoptosis in hepatocellular carcinoma.
Chen Y, Qian Q, Li J, Hu S, Wen Y, Tu L, Tan L, Chen W, Wang L, Fang Y, Jiang W, Xu Q, Huang D, Li X
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168235
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168235
Characterization of cyclotide Vdif A from Viola diffusa inhibits non-small cell lung cancer cells via regulation of CKS2.
He F, He Q, Li Y, Ren J, Tang X, Mao K, Zhangsun D, Gao B, Luo S, Wu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158146
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158146
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Zhao Q, Zhang HJ, Han MM, Abiti J, Dong YJ, Wang JN, Lu JT, Wang W, Zhang X, Geng SL, Qiu LL, Wang XY, Hua ZC, Wang TY, Jia YL
Synthetic and systems biotechnology 2026 Jun;12:197-208
Synthetic and systems biotechnology 2026 Jun;12:197-208
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Han M, Shi S, Guan Z, Ma W, Wang X, Jiang H, Man S
Tissue & cell 2026 Jun;100:103379
Tissue & cell 2026 Jun;100:103379
Intermittent fasting attenuates ovarian chronic inflammation in obese mice by inhibiting the CXCL12-CXCR4 axis.
Chen X, Han Z, Yu X, Hao X
International immunopharmacology 2026 Jun 15;179:116603
International immunopharmacology 2026 Jun 15;179:116603
Exploring the mechanism of Bushen KaiXuan Tongluo formula in ameliorating diabetic kidney disease based on transcriptomics and animal experiments.
Xu M, Zhao B, Wang Y, Chang Y, Li Y, Qin L, Wang H, Jia X, Zheng G, Lv C, Liu T
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Jun 15;1278:125037
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Jun 15;1278:125037
Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.
Chen J, Chen Y, Zheng H, Ding T, Xiang Y, Zhou X, Wang W, Li J, Li Z, Peng C, Fu Q, Li T, Fu Y
Journal of ethnopharmacology 2026 Jun 12;364:121498
Journal of ethnopharmacology 2026 Jun 12;364:121498
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.
Wang T, Zhang J, Lu G, Han D, Mi T, Ma X, Wang L, He Z, Niu J
Free radical biology & medicine 2026 Jul;250:134-152
Free radical biology & medicine 2026 Jul;250:134-152
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis.
Lai X, Wang Y, Zhang J, Xie H, Wu S, Wang L
Biochemical pharmacology 2026 Jul;249:117877
Biochemical pharmacology 2026 Jul;249:117877
Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways.
Liu B, Wang X, Wang Y, Zhang T, Guo R, Chen X, Zhang Z
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130947
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130947
The function and molecular mechanism of HIF-1α interacted with p-STAT3 in promoting G6PD overexpression in chronic myelogenous leukemia cells.
Ni Y, Wang L, Li Y, Duan Y, Shao H, Dong Y, Zhang J, Xu Z, Yuan L, Dou Y, Bai Z, Cui K, Teng Z, Shahzad A, Liu W, Yang Z, Zhang Q
Cellular signalling 2026 Jul;143:112451
Cellular signalling 2026 Jul;143:112451
Metformin attenuates colitis via blocking STAT3 acetylation by reducing acetyl-CoA production.
Li X, Xiang Z, Wang X, He H, Xu M, Tan C, Wu X, Zhang J, Dong W
Journal of advanced research 2026 Jan;79:393-407
Journal of advanced research 2026 Jan;79:393-407
Aspirin's therapeutic mechanism against diesel particulate matter-induced lung injury revealed by network pharmacology and experimental models.
Zhang Y, Li B, Cao H, Gao J, Wang T, Chen Q, Tao X
Drug and chemical toxicology 2026 Jan;49(1):205-215
Drug and chemical toxicology 2026 Jan;49(1):205-215
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Wang H, Jiang R, Liu C, Chen F
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Mechanistic Insights Into Astragali Radix n-Butanol on Podocyte Injury via Cell Cycle Regulation.
Li A, Wei S, Cui T, Xing J, Liu G, Qin X
Biomedical chromatography : BMC 2026 Jan;40(1):e70294
Biomedical chromatography : BMC 2026 Jan;40(1):e70294
Screening of Antiaging Active Components of Morinda officinalis and the Mechanism of Enhanced Efficacy After Salt-Steaming.
Zhang Y, Dong K, Shan G, Lian J, Shi J, Jiang L, Jia T
Biomedical chromatography : BMC 2026 Jan;40(1):e70246
Biomedical chromatography : BMC 2026 Jan;40(1):e70246
Plantaginis Semen, a Novel Natural S1PR1 Agonist, Inhibits Oxidative Stress and Inflammation to Treat Lipopolysaccharide-Induced Acute Lung Injury.
Xu W, Wu J, Lu M, Yu H, Li C
Phytotherapy research : PTR 2026 Jan;40(1):351-369
Phytotherapy research : PTR 2026 Jan;40(1):351-369
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Zhang R, Tan X, Zhang Y, Ma Y, You Z, Huang Y, Yang L
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.
Bao Z, Yang J, Li J, Cai J, Zhai P, Zhao P, Zhao B, Chen Y, Wu X
Animal bioscience 2026 Jan;39(1):240640
Animal bioscience 2026 Jan;39(1):240640
Subcutaneous Implantation of Exogenous Melatonin Induces a Polarization Effect on the Weight of Scent Glands in Muskrat.
Liu D, Liu W, Cui Y, Yi K, Zhang Y, Bai S
Journal of experimental zoology. Part A, Ecological and integrative physiology 2026 Jan;345(1):58-71
Journal of experimental zoology. Part A, Ecological and integrative physiology 2026 Jan;345(1):58-71
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Xu J, Liu W, Chen L, Zhang J, Zhang D, Huang X, Zhang G
Cell death and differentiation 2026 Jan;33(1):126-139
Cell death and differentiation 2026 Jan;33(1):126-139
Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway.
Wang Y, Zhao M, Liu S, Zheng R, Gao T
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation.
Zhao N, Zhou X, Li Z, Liang L, Bao J, Chen X, Shu P, Zhong J
Journal of photochemistry and photobiology. B, Biology 2026 Jan;274:113343
Journal of photochemistry and photobiology. B, Biology 2026 Jan;274:113343
Hyperuricemia exacerbates acetaminophen hepatotoxicity via JNK activation and mitophagy reduction.
Liu Y, Peng B, Li D, Chen J, Lai Y, You Y, Jiang Z, Zhou X, Wu C, Chen L, Kwan HY, Yu L, Zuo D, Zhao X
Biochemical pharmacology 2026 Jan;243(Pt 1):117487
Biochemical pharmacology 2026 Jan;243(Pt 1):117487
Diterpenoids and sesquiterpenoids from Euphorbia helioscopia and their neuroprotective activity.
Zheng DK, Liu XJ, Chen X, Liu L, Mao SC
Phytochemistry 2026 Jan;241:114653
Phytochemistry 2026 Jan;241:114653
Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress.
Zhu W, Li Q, Ji Z, Wu D, Chen J, Zhao Y, Wu H
Biomedical reports 2026 Jan;24(1):3
Biomedical reports 2026 Jan;24(1):3
Effects of repetitive transcranial magnetic stimulation on apoptosis and MAPK/PI3K-AKT signaling pathways in rats with spinal cord injury.
Xu Q, Su J, Lei Q, Liu J, Wang J, Yang M, Song J, Chen H, Lu J
Brain research bulletin 2026 Jan;234:111687
Brain research bulletin 2026 Jan;234:111687
Pyraclostrobin induces brain oxidative stress, apoptosis and inflammation through mitochondrial phosphorylation-induced ROS activation of the p38 MAPK pathway.
Li Y, Chen J, Chen Y, Dong Q, Jin X, Zhao P, Dong Z
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106787
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106787
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway.
Han S, Pu Y, Liu Z
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106728
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106728
Macrophage migration inhibitory factor alleviates irradiation induced apoptosis of BMSCs through the LncRNA MEG3/NOX4 axis.
Hu K, Zhou H, Hu H, Bai Z, Mou L, Wu S, Shou Z, Liu C, Chen C
Open medicine (Warsaw, Poland) 2026 Jan;21(1):20251339
Open medicine (Warsaw, Poland) 2026 Jan;21(1):20251339
Unraveling the role of host kinase PIM1 in Toxoplasma gondii infection: Implications for therapies.
Pan L, Zhang F, Yang Y, Sun Y, Song L, Zhang F, Zhu J, Wang Y, Wang C, Luo Q, Zhang W, Yu L, Cao Y
PLoS neglected tropical diseases 2026 Jan;20(1):e0013915
PLoS neglected tropical diseases 2026 Jan;20(1):e0013915
Isoimperatorin inhibits cell proliferation and induces apoptosis via regulating PI3K/AKT pathway in acute lymphoblastic leukemia.
Xiao J, Wang Y
Molecular immunology 2026 Jan;189:181-191
Molecular immunology 2026 Jan;189:181-191
Canagliflozin inhibits p38MAPK signaling to protect tubular epithelial cell against pyroptosis in sepsis-induced acute kidney injury.
Zhu YF, Wang J, Bian RX, Guo CL, Song LG, Nie CY, Liu G
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120069
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120069
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels.
Cheng G, Qi C, Xu H, Wang X, Li M, Chen H, Zheng P, Liu Y, Liu J, Zhao X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159705
Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways.
Wu W, Bamba D, Zhang Z, Wu F, Li Y, Qi W, Liu Y, Zhang T, Su Y, Wang X, Wang H, Duan S, Ne J, Wang W, Liu J, Tang J, Li F, Wu Q, Li Y, Yang F, Yang L
Chinese herbal medicines 2026 Jan;18(1):178-187
Chinese herbal medicines 2026 Jan;18(1):178-187
SMART-guided discovery of Sarpagine-type monoterpene indole alkaloids from Rauvolfia vomitoria and the synergistic effects with cisplatin against human ovarian cancer cells.
Yang K, Zhang Y, Miao R, Luo C, Yuan X, Ma X, Wang N, Zhan G, Guo Z
Bioorganic chemistry 2026 Jan;168:109284
Bioorganic chemistry 2026 Jan;168:109284
Unraveling the neuroprotective mechanism of gastrodin against CRS-induced depression in adult male mice via Notch3: Integration of proteomics, transcriptomics, molecular docking, and cellular validation.
Xiang H, Tan C, Long M, Zhang J, Zou X, Cai G, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157705
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157705
Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells.
Wang X, Xu P, Luan S, Jiao Y, Gao Y, Zhao C, Fu P
Cancer medicine 2026 Jan;15(1):e71446
Cancer medicine 2026 Jan;15(1):e71446
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H(2)O(2)-Damaged PC12 Cells.
Zhang Z, Zhou Z, Zhang P, Huo Y
Immunity, inflammation and disease 2026 Jan;14(1):e70324
Immunity, inflammation and disease 2026 Jan;14(1):e70324
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Zhang S, Xie Y, Zhang L, Qi Y, Liao Q, Xu C, Yang S, Zhou H, Tan Q, Qi S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.
Cui S, Luo X, Fan G, Jiang J, Wang Y, Yang E, Ma J, Zhang Z, Wang Y, Wang J, Wang D, Wang H, Cheng L, Tian J, Dong Z, Liu Y, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(4):e09933
Injectable BMSC-Based Extracellular Matrix-Mimicking Microtissue for Myocardial Infarction Repair.
Yao L, An H, Fan C, Lan Q, Zhong H, Zhang Y, Zhou L, Hao P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e00299
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e00299
USP11-PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA-cGAS-STING Pathway After Intracerebral Hemorrhage.
He J, Qin Z, Cai Y, Liu H, Wang T, Hu Q, Xu Y, Yang P, Wu X, Qu Y, Guo W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14283
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e14283
Effect of selenium-enriched Ganoderma lucidum powder in testicular tissues, oxidative stress biomarkers and antiapoptotic capacities in roosters.
Chen R, Liu Y, Hu W, Yang J, Zhang M, Xu D, Liu L, Li X, Yang W, Liu B, Fan Q, Yang X, Li P
Poultry science 2026 Jan;105(1):106185
Poultry science 2026 Jan;105(1):106185
Ssc-miR-130b Inhibits Lipid Accumulation in Porcine Intramuscular Preadipocytes by Activating Apoptosis via Bcl-2/Bax/Caspase-3 Signaling Pathway.
Li L, Chen Y, Wang L, Cheng J, Lu Y, Pan S
Animal science journal = Nihon chikusan Gakkaiho 2026 Jan-Dec;97(1):e70164
Animal science journal = Nihon chikusan Gakkaiho 2026 Jan-Dec;97(1):e70164
FTO-Eci1 Axis Mediates Exercise-Induced Cardioprotection in Pressure Overload Mice.
Wang J, Chang Z, Lin S, Sha G, Zeng W, Huang Q, Deng Q, Wang S, Hu M, Xia J
Biomolecules 2026 Jan 7;16(1)
Biomolecules 2026 Jan 7;16(1)
Subchronic exposure to T-2 toxin triggered neurobehavioral damage in developing juvenile rats was associated with oxidative stress and mitochondrial pathway-induced apoptosis of hippocampal neurons.
Zhou J, Meng F, Li Q, Wang H, Zou N
Chemico-biological interactions 2026 Jan 5;423:111824
Chemico-biological interactions 2026 Jan 5;423:111824
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Zhang H, Chang A, Xu X, Peng H, Zhang K, Yang J, Li W, Wang X, Wang W, Yin X, Qu C, Dong X, Ni J
Current issues in molecular biology 2026 Jan 27;48(2)
Current issues in molecular biology 2026 Jan 27;48(2)
GJB2 c.109G > A mutation activating IFI27-mediated mitochondrial apoptosis pathway leading to hereditary non-syndromic hearing loss.
Chen Y, Zhao P, Lin Q, Zeng Y, Qiu X, Huang T, Tang J, Xu L
Scientific reports 2026 Jan 26;16(1):6240
Scientific reports 2026 Jan 26;16(1):6240
Rhodotorula mucilaginosa JAASSRY1 Ameliorates Cyclophosphamide-Induced Immunosuppression by Regulating Gut Microbiota and Activation of Spleen TLR4/MyD88/NF-κB Pathway.
Yang M, He Y, Miao X, Sun M, Niu H, Hua M, Li D, Xu H, Wang J
Journal of microbiology and biotechnology 2026 Jan 21;36:e2510031
Journal of microbiology and biotechnology 2026 Jan 21;36:e2510031
NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis.
Xiao H, Wang H, Yang H, Li F, Ma L, Ma H
ACS omega 2026 Jan 20;11(2):2499-2512
ACS omega 2026 Jan 20;11(2):2499-2512
Exploring the molecular function of LYPD3 from pan-cancer to lung cancer: based on bioinformatics and cellular experiments.
Shi YX, Yan JH, Dai PH
Mammalian genome : official journal of the International Mammalian Genome Society 2026 Jan 19;37(1):26
Mammalian genome : official journal of the International Mammalian Genome Society 2026 Jan 19;37(1):26
CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation.
Li N, Huang E, Wang R, Li J, Yuan X
Stem cell research & therapy 2026 Jan 17;17(1):83
Stem cell research & therapy 2026 Jan 17;17(1):83
Zhigancao decoction alleviates Parkinson's disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosis.
Zhang J, Yu X, Fang Y, Li W, Cui Q, Liu X, Jiang Y, Zhang Y, Xu C, Sun X, Lu Y
iScience 2026 Jan 16;29(1):114489
iScience 2026 Jan 16;29(1):114489
Pharmacologic Modulation of the PAR-2-ERK Axis by Statins Converts Inflammatory Survival Signalling into Apoptosis in Colorectal Cancer Cells.
Amiri L, Patnaik R, Varghese RL, Huda B, Banerjee Y
International journal of molecular sciences 2026 Jan 16;27(2)
International journal of molecular sciences 2026 Jan 16;27(2)
Lactate attenuates hepatic ischemia-reperfusion injury by reducing intrahepatic inflammation and suppressing hepatocyte-neutrophil interaction via the IL-33/ST2 pathway.
Fang P, Zhang Z, Zhu J, Xu H, Han X, Xu N, Wang X, Zhou L, Du X, Jin H, Zhang D, Sun G
Cell communication and signaling : CCS 2026 Jan 15;24(1):108
Cell communication and signaling : CCS 2026 Jan 15;24(1):108
IL-24 ameliorates cognitive dysfunction via the inhibition PERK-eIF2α Signaling pathway in Alzheimer's disease.
Du Y, Zheng X, Yue X, Fu P, Diao J, Zhang A, Cheng H, Yang H, Bi J, Zhou Q, Wang P
International immunopharmacology 2026 Jan 15;169:116039
International immunopharmacology 2026 Jan 15;169:116039
MMSA-1 is regulated by Wnt/TCF4 and involved in multiple myeloma progression and invasion via RAS/RAF signaling pathway.
Meng S, Liu H, Gu L, Wang J, Wang J, Zhao W
Annals of hematology 2026 Jan 15;105(1):11
Annals of hematology 2026 Jan 15;105(1):11
Ginsenoside Rb1 mitigates diabetes-induced erectile dysfunction in rats by reducing oxidative stress and modulating the PI3K/AKT/eNOS pathway.
Liu ZH, Chen WB, Li JZ, Wang XS, Liu L, Liu HW, Chen GZ, Pan C, Yuan MZ
Asian journal of andrology 2026 Jan 1;28(1):57-63
Asian journal of andrology 2026 Jan 1;28(1):57-63
Theacrine protects vascular endothelial cells against oxidative damage after ischemic stroke by inhibiting Rac1 and activating Nrf2 pathway.
Zhang Y, Li Y, Li X, Liao P, Chen W, Feng Y, Zhang X, Chen Y, Nan L, Li H, Yan G
International immunopharmacology 2026 Jan 1;168(Pt 2):115951
International immunopharmacology 2026 Jan 1;168(Pt 2):115951
Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway.
Liu Z, Yu Q, Zhou X, Ma H, Wei R, Xia J
International immunopharmacology 2026 Jan 1;168(Pt 2):115926
International immunopharmacology 2026 Jan 1;168(Pt 2):115926
Dental pulp stem cell-derived exosomes promote axonal repair in spinal cord injury by suppressing neuroinflammation and apoptosis.
Li F, Liao X, Huang Y, Zhou H, Nie X
Tissue & cell 2026 Feb;98:103175
Tissue & cell 2026 Feb;98:103175
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.
Yu M, Zhang Q, Shang W, Wei S, Wen H, Huo S, Li X, Li X, Zhang H, Tian Y
Tissue & cell 2026 Feb;98:103145
Tissue & cell 2026 Feb;98:103145
Gemfibrozil Prevents Myocardial Ischemia-Reperfusion Injury in Mice Through AMPK Activation.
Jiang Y, Wang W, Li Q, Xia T, Xia B, Huang C, Lu X, Yin L, You Q, Yang R
Clinical and experimental pharmacology & physiology 2026 Feb;53(2):e70106
Clinical and experimental pharmacology & physiology 2026 Feb;53(2):e70106
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer.
Zhao WH, Huang H, Ding C, Zhao ZX, Jia CY, Wang YJ, Hu ZX, Wang GN, Li YW, Liu JH, Liu HY, Chen J
Acta pharmacologica Sinica 2026 Feb;47(2):391-403
Acta pharmacologica Sinica 2026 Feb;47(2):391-403
Krüppel-like factor 15 ameliorates alcohol-induced liver injury in mice via regulation of the PFKFB3/AKT axis.
Chen H, Yang L, Li XF, Han SY, Zhao Q, Xiao RC, Ou ZY, Fang L, Du Y
Acta pharmacologica Sinica 2026 Feb;47(2):357-369
Acta pharmacologica Sinica 2026 Feb;47(2):357-369
Cycloastragenol Regulates Mitochondrial Homeostasis-Mediated Renal Tubular Injury to Ameliorate Diabetic Kidney Disease by Directly Targeting ERK to Modulate TFEB.
Gao G, Liu Z, Wang H, Wang P, Liu S, Liu R, Wu Y, Wang Z, Xu J, Zhang Z, Zhang X, Xie Z
Phytotherapy research : PTR 2026 Feb;40(2):455-472
Phytotherapy research : PTR 2026 Feb;40(2):455-472
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway.
Fu Y, Ye C, Zhu Y, Chen T, Li Z, Chen Y
Phytotherapy research : PTR 2026 Feb;40(2):420-435
Phytotherapy research : PTR 2026 Feb;40(2):420-435
ELF5 modulates casein synthesis in goat mammary epithelial cells via JAK2/STAT5 signaling pathway.
Guo Y, Ma C, Meng T, Tu T, Cui S, Ling Y, Zhang Y, Liu H, Song N
Animal bioscience 2026 Feb;39(2):250181-0
Animal bioscience 2026 Feb;39(2):250181-0
A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation.
Gong P, Wang Y, Qiu JH, Li G, Chen KW, Li Z, Wang X, Wang L
Materials today. Bio 2026 Feb;36:102627
Materials today. Bio 2026 Feb;36:102627
CACNB1 alleviates mepivacaine‑induced myocardial ischemia/reperfusion injury by promoting Nrf2 nuclear translocation.
Shao Q, Zhang J, Wang H
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
Novel Glycyrrhizinic Acid Derivative YCY-20 Inhibits Cerebral Ischemia/Reperfusion Induced Apoptosis via the AGE-RAGE/MAPK Pathway.
Luo J, Qin X, Chen J, Yu X, Liu Z, Lv J, Pan X, Chen Y, Wei L
CNS neuroscience & therapeutics 2026 Feb;32(2):e70792
CNS neuroscience & therapeutics 2026 Feb;32(2):e70792
Bacteroides acidifaciens alleviates high-fat diet-induced obesity-related osteoporosis by regulating gut microbiota and bile acid metabolism via the gut-bone axis.
Zheng C, Xie J, Tang F, Wang Z, Liu L, Pi Y, Zhong Y, He Z, Liu T, Zheng J, Luo J
Microbiological research 2026 Feb;303:128393
Microbiological research 2026 Feb;303:128393
Thymoquinone Protects Against Cardiac Hypertrophy via PPAR-γ/PI3K/Akt Pathway.
Qiu RB, Wu ZM, Xu ZQ, Hu LJ, Zhao ST, Zeng RY, Qiu ZC, Zhou LF, Lai SQ, Wang WJ, Wan L
Journal of cellular and molecular medicine 2026 Feb;30(3):e70911
Journal of cellular and molecular medicine 2026 Feb;30(3):e70911
Zinc Alleviates Oxidative Stress Injury of the Testis Induced by Zearalenone through Sirt3-Foxo3 Pathway in Mice.
Zhao Z, Yao J, Guo Z, Song L, Ma J, Song Y, Ma Y, Zhao J
Biological trace element research 2026 Feb;204(2):769-785
Biological trace element research 2026 Feb;204(2):769-785
OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis.
Pan Z, Kong L, Shi F, Ying K, Xie H, Wu X, Lin G, Yao J, Chen Z, Wang Y, Chen G, Zhu Q
Cellular signalling 2026 Feb;138:112217
Cellular signalling 2026 Feb;138:112217
DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.
He B, Deng M, Guan R, Mei J, Zou H, Tang Y, Yang Z, Zheng Z, Lin W, Li S, Guo R, Zhao R, Wei W
European journal of medical research 2026 Feb 9;
European journal of medical research 2026 Feb 9;
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.
Yang X, Wang R, Xu G, Yang Z, Yao X, Liu G, Yu J, Xu B, Luo H, Cao Y
Medical oncology (Northwood, London, England) 2026 Feb 7;43(3):146
Medical oncology (Northwood, London, England) 2026 Feb 7;43(3):146
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Ma CS, Han B, Guo JR, Guo JF, Shi CK, Liu YX, Yi WJ, Zhang LY, Deng AJ, Wang YS, He MT
Journal of translational medicine 2026 Feb 7;24(1)
Journal of translational medicine 2026 Feb 7;24(1)
COPD airway epithelial cells-derived extracellular vesicles contribute to endothelial dysfunction and atherosclerosis via the miR-141-3p/PDCD4 axis.
Wang Z, Shi J, Liang Y, Li D, Luo Y, Zhang Y, Chen Y, Li N, Gai X, Sun Y
Journal of nanobiotechnology 2026 Feb 6;24(1)
Journal of nanobiotechnology 2026 Feb 6;24(1)
UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation.
Shi H, Cai Y, Liu Y
Biological research 2026 Feb 5;59(1)
Biological research 2026 Feb 5;59(1)
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Sun Y, Wei T, Xu H, Li H, Zhou C, Liu X, Li Y, Huang S, Zhang Q, Duan X
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Ginsenoside Rg5 Targets PRDX1 to Disrupt Redox Homeostasis and Induce Mitochondria-Dependent Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.
Ye HL, Wang YN, Li GA, Jin XH, Wu GT, Li Y, Jin YH
Molecules (Basel, Switzerland) 2026 Feb 5;31(3)
Molecules (Basel, Switzerland) 2026 Feb 5;31(3)
Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.
Cai J, Zhao B, Bao Z, Li Y, Han X, Chen Y, Wu X
BMC veterinary research 2026 Feb 5;22(1)
BMC veterinary research 2026 Feb 5;22(1)
Bioinformatic analysis and cellular functional assays uncover the role of NXPH4 in breast cancer.
Yang DD, Xue ZK, Jia SQ, Liu CH, Yang R, Chen CL, Huang YZ, Zhao XC, Huang GL, Hou JX
Discover oncology 2026 Feb 5;17(1)
Discover oncology 2026 Feb 5;17(1)
Single-Nucleus RNA Sequencing Reveals SPP1(+) Macrophages Induce Cardiomyocyte Apoptosis to Promote Atrial Fibrillation Susceptibility.
Wang W, Dong Y, Yi H, He L, Jiang Y, Long L, Xia Z, Li J
Journal of cardiovascular development and disease 2026 Feb 5;13(2)
Journal of cardiovascular development and disease 2026 Feb 5;13(2)
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
Lidocaine potentiates thermal ablation in cholangiocarcinoma by modulating TRPV6-Driven Ca(2+)/PI3K/AKT/HSF-1 signaling pathway.
Chen PP, Lin YK, Xia MX, Feng HB, Pan YF, Tan YX, Xu MY, Xing XH, Yao XM, Hu B, Wang HY, Qin WH, Dong LW
Cancer letters 2026 Feb 28;639:218226
Cancer letters 2026 Feb 28;639:218226
Resveratrol and AG490 Overcome Glioblastoma Cells' Resistance to Monotherapy by Inhibiting JAK2/STAT3 Signalling Pathway.
Ullah A, Han C
Cancers 2026 Feb 28;18(5)
Cancers 2026 Feb 28;18(5)
Pulsatilla Saponin B4 Alleviates H(2)O(2)-Induced Oxidative Stress and Apoptosis via the AMPK/Nrf2 Pathway in Bovine Mammary Epithelial Cell Models.
Zhang H, Yi S, Ding P, Hao B, Shao D, Wang S
Antioxidants (Basel, Switzerland) 2026 Feb 27;15(3)
Antioxidants (Basel, Switzerland) 2026 Feb 27;15(3)
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W
Biology direct 2026 Feb 26;21(1)
Biology direct 2026 Feb 26;21(1)
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Yan Y, Ren X, Xiao Y, Li F, Guo J, Ji K, Hei Z, Zhang Z, Sun Y
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942
Cell reports 2026 Feb 24;45(2):116942
A novel molecule ZYZ329 targeting histone methyltransferase SMYD3 suppresses pathological angiogenesis via the driven mitochondrial ROS/HIF-1α/VEGFA axis.
Ye Q, Cai J, Lu X, Zhu Q, Li Q, Ren M, Ding Q, Mao Y, Zhu YZ
Journal of translational medicine 2026 Feb 24;24(1)
Journal of translational medicine 2026 Feb 24;24(1)
A stimuli-responsive mitochondria-targeted nanoplatform for glioblastoma therapy: modulating the blood-brain barrier and delivering precise chemotherapy.
Luo W, Zhang F, Wang K, Liu J, Chen W, Min Z, Chen X, Wu T, Yang Z, Wen L
Journal of nanobiotechnology 2026 Feb 21;24(1)
Journal of nanobiotechnology 2026 Feb 21;24(1)
DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.
Guan K, Zhao S, Zhang G, Wang Y, Song D, Ding Y
iScience 2026 Feb 20;29(2):114347
iScience 2026 Feb 20;29(2):114347
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Zhao Z, Fu J, Han J, Pan Y, Xue B, Sun X, Ma Y, Li B, Chen K, Li Z, Liang Z, Zhou X, Guo Y, Tu P
Journal of biological engineering 2026 Feb 2;20(1)
Journal of biological engineering 2026 Feb 2;20(1)
Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.
Wen Y, Song Y, Pan S, Zhang N, Tong X
Scientific reports 2026 Feb 2;16(1):6918
Scientific reports 2026 Feb 2;16(1):6918
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma.
Wang Y, Diao P, Lv P, Qi N, Wang Z, Yan E, Li J, Wang Y, Wang D, Wu Y, Cheng J
Cell reports. Medicine 2026 Feb 17;7(2):102622
Cell reports. Medicine 2026 Feb 17;7(2):102622
Growth differentiation factor 15 promotes the malignant progression of multiple myeloma via activation of PI3K/Akt/NF-κB signaling pathway.
Fan H, Wu Y, Peng Y, Wang L, Tu S, Peng H, Yang J, Li X, Shi Z, Li M, Song K
Journal of translational medicine 2026 Feb 17;24(1)
Journal of translational medicine 2026 Feb 17;24(1)
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
Zhu L, He C, Shi H, Shao G, Sun L
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway.
Wang Y, Chen W, Liu W, Zhang X, Wang Y, Dai N
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Feb 17;
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Feb 17;
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.
Wang H, Luo K, Li S, Jin D, Ou L, Liu C, Wu Q
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)
Integrated Analysis of Transcriptome and sRNA Sequencing Reveals Mmu-miR-503-5p Regulates the Aluminum Chloride Stress Response of GC-1spg Cells by Targeting Islr.
Huang J, Wei Z, Guo Y, Xie D, Zhou J, Yi S, Liu Z
Toxics 2026 Feb 15;14(2)
Toxics 2026 Feb 15;14(2)
Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.
Luo Z, Xu G, Li C, Sun Z, Chen H, Yang M, Ye Y, Chen Q, Xu B, Luo H, Sun B
Journal of medicinal chemistry 2026 Feb 12;69(3):3457-3476
Journal of medicinal chemistry 2026 Feb 12;69(3):3457-3476
14-3-3β knockdown inhibits migration and colony formation of esophageal squamous cell carcinoma cells and is associated with weakened p-AKT signaling.
Hu QH, Zhu MQ, Chen K, Huang JS, Tao Q, Guo ZB
Hereditas 2026 Feb 11;163(1)
Hereditas 2026 Feb 11;163(1)
Pseudolaric acid B promotes lung cancer cells ferroptosis depending on JNK/ERK-mediated upregulation of survivin.
Li Y, Yu C, Yang S, Sai B, Chen X, Chen P, Liu H, Jia J, Zhang Y, Sun R, Shi S
Scientific reports 2026 Feb 11;16(1)
Scientific reports 2026 Feb 11;16(1)
Qingyu Yangjing formula ameliorates cyclophosphamide-induced oligoasthenospermia by regulating the hypothalamic-pituitary-gonadal axis and inhibiting testicular oxidative stress and apoptosis in rats.
Li X, Qin L, Sun Y, Zou K, Zhao C, Xiao M, Yan S, Zhang X, Shen Y, Tian L, Liu S
Journal of ethnopharmacology 2026 Feb 10;356:120842
Journal of ethnopharmacology 2026 Feb 10;356:120842
Antioxidant properties of low-molecular-weight Ulva prolifera polysaccharides against H₂O₂-induced oxidative damage in BRL 3A cells and zebrafish.
Tan J, Zheng Y, Ahn G, Wang L, Mao X
Food chemistry 2026 Feb 1;501:147475
Food chemistry 2026 Feb 1;501:147475
Hippocampal GPR17 down regulation ameliorates CMS-induced depression-like behaviors in mice.
Xie Z, Fan B, Zhi TT, Wu Y, Yang Y, Wu L, Wu X
Neuropharmacology 2026 Feb 1;283:110757
Neuropharmacology 2026 Feb 1;283:110757
T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.
Lu C, Shao L, Li H, Gao X, Mei Y, Sun B
International immunopharmacology 2026 Feb 1;170:116100
International immunopharmacology 2026 Feb 1;170:116100
Hypoxia-preconditioned cardiomyocyte-derived extracellular vesicles alleviate myocardial ischemic injury by reprogramming macrophage polarization via the Fgl2/NF-κB pathway.
Zhang Z, Shen H, Zhang S, Zhou J, Zhang M, Wang Y, Zheng Y, Chang Y, Liang X, Hu X, Gao W
International immunopharmacology 2026 Feb 1;170:116077
International immunopharmacology 2026 Feb 1;170:116077
DNA Methylation-Regulated FAM107A Affects Colorectal Carcinogenesis by Inhibiting FOXM1.
Liu Y, Sun J, Shi Y, Wang L, Zhang X, Chen L
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2026 Dec;39(1):2633933
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2026 Dec;39(1):2633933
Identification of mitochondrial permeability transition-related gene signatures to predict lung adenocarcinoma survival and drug response.
Liu L, Gao M, He W, Wang M, Zhou S, Wang X, Shu Y
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-35
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-35
An oral-gut microbial metabolite links Fusobacterium nucleatum to aggravated myocardial ischemia-reperfusion injury.
Li Y, Xu Q, Zhu M, Wang W, Liu Y, Yang H, Liu Y
Gut microbes 2026 Dec 31;18(1):2662082
Gut microbes 2026 Dec 31;18(1):2662082
RFRP-3 suppresses ovarian granulosa cell function in Tan sheep via dual signaling pathways: PI3K/AKT/mTOR and MAPK/ERK1/2.
Wei S, Dai T, Song W, Ma Y, Dan X
Theriogenology 2026 Aug;260:117909
Theriogenology 2026 Aug;260:117909
INHBB promotes liver metastasis of colorectal cancer via regulation of TGF-β/Smad signaling, EMT and anoikis resistance.
Yang N, Dai D, Zhao J, Zhao H, Jiang H, Liu J, Liu F, Chen X
Tissue & cell 2026 Apr;99:103258
Tissue & cell 2026 Apr;99:103258
Scutellarin reduces apoptosis in R28 cells induced by continuous hydrostatic pressure combined with oxygen-glucose deprivation through the Keap1/Nrf2/NF-κB pathway.
Cui H, Huang Y, Xia X, Li J, Peng J, Yang Y, Peng Q
Tissue & cell 2026 Apr;99:103234
Tissue & cell 2026 Apr;99:103234
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling.
Deng Q, Liu Z, Ye Q, Liu J, Fu Z, Zhang X, Luo J, Lu Z, Yue P, Xiao J, Xiao Q
International journal of molecular medicine 2026 Apr;57(4)
International journal of molecular medicine 2026 Apr;57(4)
Integrated Network Pharmacology and Experimental Study on Shikonin-Induced Male Reproductive Toxicity.
Qian R, Wang H, Li J, Cui Y, He Y, Chen H, Liu S, Luo T
Journal of applied toxicology : JAT 2026 Apr;46(4):1302-1313
Journal of applied toxicology : JAT 2026 Apr;46(4):1302-1313
Excessive fluoride induces renal cell apoptosis and subsequent renal dysfunction.
Zhang Y, Xu Z, Xie P, Xiao Y, Dong S, Chen C, Chen Q
Toxicology letters 2026 Apr;418:111862
Toxicology letters 2026 Apr;418:111862
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Xu J, Wan W, Mu H, Gong S, Liu Y, Deng T
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Chrysophanol Attenuates Glucocorticoid-Induced Osteoporosis by Targeting the E74-Like Factor 5/Osteoglycin-Regulated PI3K/AKT/mTOR Signaling Axis: An In Vitro and In Vivo Study.
Chen R, Yang C, Chen C, Yang F, Xiao H, Yang A, Peng B, Geng B, Xia Y
Phytotherapy research : PTR 2026 Apr;40(4):2143-2165
Phytotherapy research : PTR 2026 Apr;40(4):2143-2165
ELAVL1 interacts with APP and promotes Aβ-induced apoptosis in Alzheimer's disease by activating Bcl-2/Bax signaling.
Fu J, Ding C, Li W, Lei J, Wang H, Meng L, Lin X, Chen W, Gao H
Experimental neurology 2026 Apr;398:115613
Experimental neurology 2026 Apr;398:115613
Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair.
Li Y, Hu J, Ran B, Zhong H, Zhong N, Zhong Y, Fu X, Liu X, Wu G, Zhong Q, Li J
Materials today. Bio 2026 Apr;37:102783
Materials today. Bio 2026 Apr;37:102783
Intestinal epithelial protection and gut microbiota modulation by Ganoderma lucidum proteoglycan are associated with its hypoglycemic potential in type 2 diabetes.
Zhang Q, Chen J, Zhang Y, Wang Y, Li J, Pan Y, Zhang Z, Yang H, He Y, Zhou P
International journal of biological macromolecules 2026 Apr;354:151441
International journal of biological macromolecules 2026 Apr;354:151441
The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.
Feng J, Gao S, Hu Y, Sheng W
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
CNS neuroscience & therapeutics 2026 Apr;32(4):e70811
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Ren J, Wu S, Su T, Li H, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Urinary microbiome and metabolomic profiling reveal propionic acid as an enhancer of BCG immunotherapy in bladder cancer.
Liu J, Luo Y, Chen L, Xiong W, An Y, Ma Z, Zhang D
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr;1872(4):168192
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr;1872(4):168192
Genistein suppresses renal fibrosis in chronic kidney disease through regulation of the CCAR2/SIRT1/p53 signaling axis.
Li T, Bai QX, Luo KM, Jia J, Wang L, Tan RZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157998
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157998
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
Sun F, She R, Yang T, Chen B, Liao Z, Liao J, Mei Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157928
Co-exposure to polystyrene nanoplastics and hexachlorocyclohexane induces enhanced human sperm toxicity in vitro.
Liu P, Wang D, Zeng Y, Wang H, Wan F, Wu J, Huang Y, Zeng L, Yan L
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr;141:109201
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr;141:109201
The Herbal Pair Daphniphyllum calycinum-Polygonum hydropiper Alleviates Gastric Mucosal Injury via Regulating Autophagy and Targeting the TLR4/NF-κB/NLRP3 Pathway.
Zhi Y, Zhou K, Huang X, Li Y, Zhu Y, Xie Y, Ren S
Food science & nutrition 2026 Apr;14(4):e71768
Food science & nutrition 2026 Apr;14(4):e71768
GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.
Li WW, Li QW, Yu J, Sui XN, Wang MM, Yin NN, Liu X
Odontology 2026 Apr;114(2):893-902
Odontology 2026 Apr;114(2):893-902
Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death.
Sang RX, Wang YQ, Wu XY, Li Z, Liu XM, Xie CZ, Qiao X, Feng YK, Xu JY
Journal of medicinal chemistry 2026 Apr 9;69(7):8148-8167
Journal of medicinal chemistry 2026 Apr 9;69(7):8148-8167
Radiomodulatory and antioxidant properties of a novel pyrazine-linked quinazolinone sulfonamide derivative: Insights into renal apoptosis.
Karam HM, Mekkawy MH, Abd-ElRaouf A, Soliman AM, Ghorab MM
Naunyn-Schmiedeberg's archives of pharmacology 2026 Apr 9;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Apr 9;
Novel transcription factor zinc finger 514 suppresses lung adenocarcinoma progression and enhances cisplatin sensitivity via transcriptional repression of COL1A1.
Sun S, Ma G, Cheng L, Zhang H, Fan G, Wu L, Zhang X, Xue F, Fu T, Ji X, Wan Q, Liu Y
British journal of cancer 2026 Apr 9;
British journal of cancer 2026 Apr 9;
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Xu B, Ji X, Li L, Zhu L, Wang L, Kang J, Yang S, Fan T
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
Ye J, Wang D, Pang H, Liu Q, Pan Z, Wang L, Liu B, He G
European journal of medicinal chemistry 2026 Apr 5;307:118633
European journal of medicinal chemistry 2026 Apr 5;307:118633
SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction.
Liu X, Zong Y, Liu K, Shi X, Zhao Z, Shan C, Sun Y
Cell reports 2026 Apr 4;45(4):117251
Cell reports 2026 Apr 4;45(4):117251
Selective Radioprotection by the Fusion Antioxidant Enzyme GS1XR Via an MMP-2/9-Cleavable Cell-Penetrating Switch.
He H, Chu J, Lin L, Lu L, Li C, Han Y, Pan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71768
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71768
Combining network pharmacology and experimental validation to study the action and mechanism of brusatol against lung adenocarcinoma.
Jin X, Yang S, Pan D, Jin B, Zhang Y, Yang C
Scientific reports 2026 Apr 3;
Scientific reports 2026 Apr 3;
Triple-Targeted Peptide-Photosensitizer-Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma.
He X, Liang X, Yu J, Rong J, Hu J, Xu C, Cai Z, Chen J, Zhang Y, Pu X, Sun P, Wu H, Sun B
ACS nano 2026 Apr 28;20(16):12577-12595
ACS nano 2026 Apr 28;20(16):12577-12595
Sugiol Alleviates Cerebral Ischemia/Reperfusion Injury in the Early Phase Involving the LRRK2/NF-κB Pathway.
Yang J, Gao L, Sun Y
Cell biochemistry and biophysics 2026 Apr 25;
Cell biochemistry and biophysics 2026 Apr 25;
Florfenicol impairs steroid hormone secretion in bovine ovarian granulosa cells: Involvement of the cAMP/PKA/StAR signaling pathway and oxidative stress.
Zhao J, Zhou X, You B, Cheng B, Hu J, Lu Y, Xu D, Zhang X, Yan C, Gao Q, Liu H, Jin Q
Theriogenology 2026 Apr 23;261:117956
Theriogenology 2026 Apr 23;261:117956
Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD(+) Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
Liu J, Guo X, Wang N, Zhang X, Wang X, Li G, Hou X, Yu L, Chen Y, Li R
Advanced materials (Deerfield Beach, Fla.) 2026 Apr 21;:e19122
Advanced materials (Deerfield Beach, Fla.) 2026 Apr 21;:e19122
Zona pellucida is required for oocyte actin cortex and oocyte-somatic cell interactions during oocyte growth.
Liang S, Xiang W, Quan R, Su J, Lv C, Huang H, Xiao H
Cell death discovery 2026 Apr 20;
Cell death discovery 2026 Apr 20;
Liquiritin Enhances Chemosensitivity to Doxorubicin in Breast Cancer by Promoting Ubiquitination-Mediated Degradation of MCL1.
Wang D, Sun Y, Tang T, Shi X
Molecular carcinogenesis 2026 Apr 17;
Molecular carcinogenesis 2026 Apr 17;
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Du W, Liu A, Li H, Ma X, Yang Y
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Aberrant expression of TRIM26 suppresses ferroptosis through regulating GPX4 protein stability in colorectal cancer.
Wu G, Zheng K, Xu S, Wang J, Xu J
Molecular biology reports 2026 Apr 16;53(1)
Molecular biology reports 2026 Apr 16;53(1)
Mechanisms Contributing to Inhibition of Retinal Ganglion Cell Apoptosis by AMPK in Experimental Glaucoma.
Gao Z, Yu H, Duan T, Huang Y, Li M, Yao F, Huang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71732
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71732
Targeting VDAC1-dependent mtDNA release attenuates fibroblast innate immune activation and vitiligo pathogenesis.
Lv J, Zhang H, Yu W, Jiang P, Yin C, Xu W, Cao Y, Gao R
International immunopharmacology 2026 Apr 15;175:116411
International immunopharmacology 2026 Apr 15;175:116411
Methylation of tenascin XB mediated by methyltransferase-like 3 can effectively suppress neural injury and cellular apoptosis induced by ischemic stroke.
Ding L, Feng X, Gao F
The International journal of neuroscience 2026 Apr 15;:1-13
The International journal of neuroscience 2026 Apr 15;:1-13
Phenethyl Isothiocyanate Suppresses Hepatocellular Carcinoma Progression and Immune Evasion via ZNF652 Regulation of PD-L1.
Ren D, Wu J, Zhu J, Xie C, Zhong C, Cao H, Han H, Zhu J
Phytotherapy research : PTR 2026 Apr 15;
Phytotherapy research : PTR 2026 Apr 15;
USP2 Attenuates Spermatogenic Cell Apoptosis Via PINK1/Parkin-Dependent Mitophagy in Varicocoele: A Functional Study.
Yao RJ, Xiao H, Zheng JH, Lin B, Liao SJ, He HH, Xu N, Zhou HL
Andrology 2026 Apr 10;
Andrology 2026 Apr 10;
Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway.
Jing J, Chen S, Wu X, Yang J, Liu X, Wang J, Wang J, Li Y, Zhang P, Tang Z
Neural regeneration research 2026 Apr 1;21(4):1574-1585
Neural regeneration research 2026 Apr 1;21(4):1574-1585
Inhibition of mitochondrial RNA polymerase sensitizes cancer cells to radiation by inhibiting mitochondrial respiration.
Tsunoda S, Osawa Y, Hosoya N
Journal of radiation research 2026 Apr 1;
Journal of radiation research 2026 Apr 1;
BFGF downregulates endoplasmic reticulum stress to alleviate HUVEC cell damage under high-glucose and inflammatory conditions.
Hu F, Shen W, Xu L, Xu H
Endokrynologia Polska 2025;76(3):290-300
Endokrynologia Polska 2025;76(3):290-300
FR429 from Polygonum capitatum Demonstrates Potential as an Anti-hepatic Injury Agent by Modulating PI3K/Akt Signaling Pathway.
Yang Y, He L, He M, Zhang X, Liao S, Zeng Z, Lin Y, Tu B
Biological & pharmaceutical bulletin 2025;48(4):372-382
Biological & pharmaceutical bulletin 2025;48(4):372-382
Effects of borneol on apoptosis of hypoxia/reoxygenation H9c2 cells and myocardial ischemia-reperfusion injury rats.
Zhang H, Dong J, Zhang J, Chen H, Liu T, Gan R, Wen J, Li Y
Acta cirurgica brasileira 2025;40:e402225
Acta cirurgica brasileira 2025;40:e402225
ZMIZ2/MCM3 Axis Participates in Triple-Negative Breast Cancer Progression.
Zou X, Sun M, Jiang X, Yu J, Li X, Nie B
Oncology research 2025;34(1):15
Oncology research 2025;34(1):15
ERRγ Promotes Multiple Myeloma Survival by Coordinating NF-κB Signaling and Mitochondrial Apoptosis Regulation.
Zhou X, Li Y, Jing Z, Yu W, Chen J
Oncology research 2025;33(9):2399-2420
Oncology research 2025;33(9):2399-2420
Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression.
Rong D, Su Y, Zeng Z, Yang Y, Lu H, Cao YU
Oncology research 2025;33(3):605-616
Oncology research 2025;33(3):605-616
NLR Risk Score for Predicting Patient Prognosis in Hepatocellular Carcinoma and Identification of Oncogenic Role of NLRP5 in Hepatocellular Carcinoma.
Tang M, He S, Meng B, Zhang Q, Li C, Sun Y, Sun W, Wang C, Kong Q, Liu Y, Hu L, Gao Y, Xie Q, Li J, Wu T
Oncology research 2025;33(10):3077-3100
Oncology research 2025;33(10):3077-3100
Qizhi Kebitong Formula Ameliorates Sciatic Nerve Injury in Streptozocin-induced Diabetic Mice through PERK/ATF4/CHOP Endoplasmic Reticulum Stress Signaling Pathway.
Yu H, Yang C, Wang G, Lv J, Li X, Qi W, Wang X
Current pharmaceutical design 2025;31(29):2370-2384
Current pharmaceutical design 2025;31(29):2370-2384
Effect of anemoside B4 on ameliorating cerebral ischemic/reperfusion injury.
Fei H, Huang X
Iranian journal of basic medical sciences 2025;28(1):49-55
Iranian journal of basic medical sciences 2025;28(1):49-55
Inhibition of autophagy promotes ultrasound‑targeted microbubble destruction-induced apoptosis of pancreatic cancer cells.
Chen N, Zhang X, Yang P, He X
International journal of medical sciences 2025;22(7):1708-1719
International journal of medical sciences 2025;22(7):1708-1719
Downregulation of lncRNA MNX1-AS1 promotes the ferroptosis and apoptosis of non-small cell lung cancer.
Chi X, Feng L, Wang L, Yu S, Wei M, Zhang Q, Liu X, Shao S
International journal of medical sciences 2025;22(5):1052-1063
International journal of medical sciences 2025;22(5):1052-1063
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling.
Zhang Z, Cheng D, Dang J, Wang X, Fan H, Liu D
International journal of medical sciences 2025;22(15):3906-3923
International journal of medical sciences 2025;22(15):3906-3923
Transcriptional enhanced associate domain factor 1 regulates cortactin-binding protein 2 N-terminal-like to control cell apoptosis in thyroid cancer.
Ma Q, Zhang L, Jiang S, Zhao W
CytoJournal 2025;22:74
CytoJournal 2025;22:74
Ailanthone inhibits bladder cancer tumor and cell proliferation, epithelial-mesenchymal transition, and activation of the Janus kinase/signal transducer and activator of transcription 3 signaling pathway.
Li J, Lv Y, Xue S, Li W, Zhang X
CytoJournal 2025;22:16
CytoJournal 2025;22:16
BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2.
Li S, Luo D, Liang Y, Zou Y, Pu H, Zheng M, Wang Y, Sun X, Zhu H, Zhu Y, Zhao L, Xiao J
International journal of biological sciences 2025;21(4):1666-1685
International journal of biological sciences 2025;21(4):1666-1685
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.
Li J, Han L, Wang T, Yang L, Zhou H
International journal of endocrinology 2025;2025:9927320
International journal of endocrinology 2025;2025:9927320
Astragaloside IV Alleviates H(2)O(2)-Induced Mitochondrial Dysfunction and Inhibits Mitophagy Via PI3K/AKT/mTOR Pathway.
Qi M, Wang Q, Sun R, Cheng Z, Li M, Fan X, Bai F, Yu J
Cardiovascular therapeutics 2025;2025:9549175
Cardiovascular therapeutics 2025;2025:9549175
SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.
Che J, Qiu Z, Hou H, Li Y, He L, Sun J, Zhang S, Li M, Pan S, Zhang W, Niu Y
Journal of tissue engineering and regenerative medicine 2025;2025:6659059
Journal of tissue engineering and regenerative medicine 2025;2025:6659059
Youthful systemic milieu in younger recipients alleviates acute kidney injury via attenuating apoptosis and oxidative stress in a rat kidney transplantation model.
Yu C, Zhang J, Pei J, Wu S, Wen S, Hua Y, Wei G
PloS one 2025;20(9):e0331020
PloS one 2025;20(9):e0331020
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration.
Zhang J, Zhou W, Liu Y, Hu C, Wang S, Xu J, Wei S
PloS one 2025;20(9):e0329560
PloS one 2025;20(9):e0329560
Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.
Liu X, Wang H, Wang K, Liu Y
PloS one 2025;20(7):e0322639
PloS one 2025;20(7):e0322639
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Wang Y, Liao Q, Mei X, Xu H, Luo L, Huang R, Tang Y, Zhou C
PloS one 2025;20(6):e0326687
PloS one 2025;20(6):e0326687
PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions.
Chen KY, Li XH, Chen D, Qian SD, Mei RH, Li Q, Yu XF, He XJ
PloS one 2025;20(6):e0325190
PloS one 2025;20(6):e0325190
Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis.
Yang J, Liu J, Liu X, Xu D, Zhang J
PloS one 2025;20(5):e0324909
PloS one 2025;20(5):e0324909
Enhancement of YTHDF2 plays a protective role in acute IRI models through downregulation of TUG1 expression.
He HF, Hou S, Ma XY, Huang SS, Yang B, Wang JK, Xu Y, Tan L, Li HY
PloS one 2025;20(4):e0319605
PloS one 2025;20(4):e0319605
Oncosis is the predominant type of cell death in rhabdomyolysis following exertional heat stroke.
Li C, Liu Y, Mao H, Yang W, Liu S, Shan Y
PloS one 2025;20(3):e0308586
PloS one 2025;20(3):e0308586
Exosomes from bone marrow mesenchymal stem cells protect melanocytes under vitiligo-related conditions through induction of NRF2/HO1 expression.
Sun X, Huang B, Ruan G, Xu A
PloS one 2025;20(12):e0338323
PloS one 2025;20(12):e0338323
Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells.
Armartmuntree N, Kittirat Y, Promraksa B, Loilome W, Dokduang H, Techasen A, Sansomchai P, Thanee M, O'Connor T, Kongthitilerd P, Padthaisong S
PloS one 2025;20(1):e0317111
PloS one 2025;20(1):e0317111
Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells.
Song S, Tai L, Zhou L, Jiang J, Zhao J
Open medicine (Warsaw, Poland) 2025;20(1):20241136
Open medicine (Warsaw, Poland) 2025;20(1):20241136
Lymph Node Exosomes Delivery Attenuates Myocardial Ischemia-Reperfusion Injury via Regulating PTEN-PI3K/Akt Pathway Mediated Myocardiocyte Apoptosis.
Qiao S, Wu B, Chen L, Ma L, Wang Y, Xu B, Gu R
International journal of nanomedicine 2025;20:4967-4981
International journal of nanomedicine 2025;20:4967-4981
Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer.
Wen Z, Luo S, Liu J, Huang Y, Chen G, Cai H
International journal of nanomedicine 2025;20:4235-4255
International journal of nanomedicine 2025;20:4235-4255
MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway.
Liu L, Li B, Zhang Y, Nie Y, Zhang W, Chen P, Huang C, Zhu X
Cellular and molecular gastroenterology and hepatology 2025;19(10):101548
Cellular and molecular gastroenterology and hepatology 2025;19(10):101548
6-Hydroxygenistein Ameliorates High Altitude Brain Injury via Activating PI3K/AKT Signaling Pathway Based on Transcriptomic Analysis and Experimental Validation.
Xin Y, Wang G, Yang C, Ma H, Jing L
Drug design, development and therapy 2025;19:8641-8656
Drug design, development and therapy 2025;19:8641-8656
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M
Drug design, development and therapy 2025;19:67-82
Drug design, development and therapy 2025;19:67-82
Mechanistic Exploration of Shugan Jianpi Formula for Treating Triple-Negative Breast Cancer Under Chronic Stress: A Network Pharmacology-Guided Experimental Study.
Liu F, Li L, Zhang Y, Zhang J, Tian X, Zhang D, Zhang N, Yan T, Shi S, Wu J, Jiang S
Drug design, development and therapy 2025;19:4585-4603
Drug design, development and therapy 2025;19:4585-4603
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity.
Xia C, Zhang J, Chen H, Zhou S, Jiang W, Zheng H, Lin Z, Tan Q, Sun W
Drug design, development and therapy 2025;19:3925-3947
Drug design, development and therapy 2025;19:3925-3947
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Sun J, Qi X, Yang C, Wang S, Jiang J, Wang L, Song J, Yu B, Sun M
Drug design, development and therapy 2025;19:2959-2977
Drug design, development and therapy 2025;19:2959-2977
Saikosaponin A Mediates the Anti-Acute Myeloid Leukemia Effect via the P-JNK Signaling Pathway Induced by Endoplasmic Reticulum Stress.
Sun XH, Chai YH, Bai XT, Li HX, Yang PP, Xi YM
Drug design, development and therapy 2025;19:1983-2001
Drug design, development and therapy 2025;19:1983-2001
Platycodin D Enhances Glioma Sensitivity to Temozolomide by Inhibition of the Wnt/β-Catenin Pathway.
Li H, Ouyang J, Wang X, Qian C
Drug design, development and therapy 2025;19:1811-1824
Drug design, development and therapy 2025;19:1811-1824
A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression.
Zhao H, Huang L, Liu J, Feng M, Liu Y, Li H, Gong S, Chen C, Zeng S, Ren W
Frontiers in cellular neuroscience 2025;19:1553309
Frontiers in cellular neuroscience 2025;19:1553309
GPR120/FFAR4 protects retinal vascular endothelial cells against high glucose injury via suppressing ROS-ERS mediated apoptosis.
Wang LZ, Yan JJ
International journal of ophthalmology 2025;18(3):383-389
International journal of ophthalmology 2025;18(3):383-389
Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury.
Xiang J, Shao S, Huang J, Yang N, Guo F, Tang B, Zhang L
Journal of inflammation research 2025;18:8033-8048
Journal of inflammation research 2025;18:8033-8048
Protective Effects of Irisin Against LPS-Induced Intestinal Injury and Its Influence on Gut Microbiota in Septic Mice.
Yang L, Liu M, Hu B, Yong K, Zhou J, Chen Y
Journal of inflammation research 2025;18:15081-15100
Journal of inflammation research 2025;18:15081-15100
Volatile Oil From Acorus Gramineus Rhizoma Synergizes with Crebanine to Alleviate Oxidative Stress and Endoplasmic Reticulum Stress in Myocardial Ischemia-Reperfusion Injury by Suppressing GRP78-PERK/ATF6-CHOP and MAPK-NF-κB-TNF-α Signaling Pathways.
Zha L, Cui L, Mei J, Pu J, Hao J, Fan X, Wang H, Fang H, Ma Y
Journal of inflammation research 2025;18:12929-12948
Journal of inflammation research 2025;18:12929-12948
Qijie Xiaopi Decoction Attenuates Gastric Mucosal Injury in PLGC Rats by Inducing Autophagy and Apoptosis Through PI3K/AKT/mTOR Pathway Inhibition.
Shan Y, Ma Y, Chen H, Zhao S, Shi M, Bai M, Hu J
Journal of inflammation research 2025;18:11979-11998
Journal of inflammation research 2025;18:11979-11998
Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis.
Zhao S, Chen R, An Y, Zhang Y, Ma C, Gao Y, Lu Y, Yang F, Bai X, Zhang J
Frontiers in aging neuroscience 2025;17:1522073
Frontiers in aging neuroscience 2025;17:1522073
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Yuan Q, Jiang H, Zhu M, Chu Y, Zhang Y, Bie J, Li L
Journal of Cancer 2025;16(3):765-783
Journal of Cancer 2025;16(3):765-783
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Luo Y, Wang Z, Li Y, Zhang L
Journal of Cancer 2025;16(3):708-719
Journal of Cancer 2025;16(3):708-719
Disulfidptosis-Associated CCNB2: A Prognostic Biomarker and Immune Microenvironment Modulator in Prostate Cancer.
Jiang W, Wang Q, Zhou J, Zhao Y, Qin X, Li X, Li H, Wang L, Wu G
Journal of Cancer 2025;16(13):3928-3941
Journal of Cancer 2025;16(13):3928-3941
Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.
Wu M, Chen C, Ren D, Du Z, Liu Z, Liu W
Frontiers in pharmacology 2025;16:1739201
Frontiers in pharmacology 2025;16:1739201
Berberine-taxifolin co-administration attenuates inflammatory response and intestinal barrier injury via nf-κB/NLRP3 suppression in colitis.
Miao G, Zhang D, Sui Z, Leng J, Deng Y, Gu X, Cao H
Frontiers in immunology 2025;16:1725084
Frontiers in immunology 2025;16:1725084
Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis.
Yang Y, Deng S, Liu T, Yin Q, Yang M, Zhang X, Jiang Z, Wang X, Zhang S, Zhang T, Wu D, Xu Y
Frontiers in immunology 2025;16:1720843
Frontiers in immunology 2025;16:1720843
Efferocytosis-associated genes serve as prognostic biomarkers for pancreatic ductal adenocarcinoma and identify P2RY6 as a therapeutic target.
Wang X, Wang W, Yang C, Wang P, Liu Y, Yu L, Zhang S, Yan X, Wang J
Frontiers in immunology 2025;16:1708441
Frontiers in immunology 2025;16:1708441
Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments.
Hao X, Mu J
Frontiers in pharmacology 2025;16:1701869
Frontiers in pharmacology 2025;16:1701869
Multi-omics analysis elucidates the therapeutic mechanisms of the Quzhi formula in metabolic dysfunction-associated steatohepatitis targeting gut microbiota, lipid metabolism, and the role of its metabolite fraxin.
Wu JX, Wu YL, Li MF, Liu N, Liu Y, Huang YP, Gan Y, Wang XY, Chai HS, Xu J, Xi Q, Guo XR, Sheng HM, Shen TT, Zhang Q
Frontiers in pharmacology 2025;16:1694242
Frontiers in pharmacology 2025;16:1694242
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Liang L, Nie X, Zhao N, Li M, Li M, Li Z, Wu M, Wu X, Lee CL, Shu P, Zhong J
Frontiers in pharmacology 2025;16:1686234
Frontiers in pharmacology 2025;16:1686234
HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.
Gong C, Wang D, Zhang Q
Frontiers in pharmacology 2025;16:1683575
Frontiers in pharmacology 2025;16:1683575
Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation.
Zhang D, Han L, Zhang W, Wang D, Huo D, Tan X, Su X, Wang M, Xu J, Cheng J, Wang J, Feng H
Frontiers in pharmacology 2025;16:1681929
Frontiers in pharmacology 2025;16:1681929
Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation.
Pei Z, Gao S, Yang J, Liu C, Pan Y
Frontiers in pharmacology 2025;16:1672570
Frontiers in pharmacology 2025;16:1672570
Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation.
Tian C, Ma A, Song T, Zhao F, Huang J, Gao J, Yan H, Chen X
Frontiers in pharmacology 2025;16:1671678
Frontiers in pharmacology 2025;16:1671678
Integrating bioinformatics and molecular experiments to reveal the critical role of the cellular energy metabolism-related marker PLA2G1B in COPD epithelial cells.
Shi J, Wang Z, Rao Y, Li D, Luo Y, Zhang Y, Pei Y, Gai X, Sun Y
Frontiers in immunology 2025;16:1666195
Frontiers in immunology 2025;16:1666195
Wuzi-Yanzong-Wan inhibits testicular mitochondrial apoptosis in rats by downregulating TAp73-Mediated P38 MAPK-ADAM17 pathway.
Liu Z, Ni X, Li J, Pan M, Xu F, Zhao H, Li L, Wang T
Frontiers in pharmacology 2025;16:1665356
Frontiers in pharmacology 2025;16:1665356
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Zhang C, Hu B, Wang C, Hou S, Lin N
Frontiers in immunology 2025;16:1662351
Frontiers in immunology 2025;16:1662351
Modulation of the lncRNA TCONS_00265853-miR-421-5p-CLOCK axis by Ziyin Buyang Formula in polycystic ovarian syndrome with circadian rhythm disruption: an integrated bioinformatics and experimental approach.
Huang H, Sun L, Jia F, Tan Y, Zhou Y
Frontiers in genetics 2025;16:1658812
Frontiers in genetics 2025;16:1658812
Loss of DJ-1 alleviates microglia-mediated neuroinflammation in Parkinson's disease via autophagy-lysosomal degradation of NLRP3.
Miao Q, Wang T, Wang H, Yu Y, Jin X
Frontiers in immunology 2025;16:1656729
Frontiers in immunology 2025;16:1656729
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Ruan LJ, Weng KQ, Zhang WY, Zhuang YN, Li J, Lin LM, Chen YT, Zeng YM
Frontiers in immunology 2025;16:1651270
Frontiers in immunology 2025;16:1651270
Cilostazol-inhibited RhoA/NF-κB signaling mitigates hippocampal inflammation and post-stroke depression.
Zhang Y, Li Y, Wu Y, Tan X, Ji T, Tang C
Frontiers in pharmacology 2025;16:1643343
Frontiers in pharmacology 2025;16:1643343
Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.
Aksüt Y, Şengelen A, Gürsoy DM, Öğütcü İ, Kuvet Ö, Pekmez M
Frontiers in pharmacology 2025;16:1643186
Frontiers in pharmacology 2025;16:1643186
The protective effect of Blautia coccoides in secondary injury of intracerebral hemorrhage.
Shao X, Zheng M, Ye C, Lu J, Li M, Su K, Lin H, He L, Qi X, Wang J
Frontiers in microbiology 2025;16:1616222
Frontiers in microbiology 2025;16:1616222
Pretreatment with Astragalus polysaccharide alleviates heat stroke-induced intestinal injury in mice.
Shan N, Wang L, Duan C, Wu Y, Jing Y, Fan H, Wang S, Wang Y, Wang S, Liu H, Cheng K, Liu L, Liu S, Zhuang R
Frontiers in pharmacology 2025;16:1612852
Frontiers in pharmacology 2025;16:1612852
Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.
Yang J, Wang Y, Xu Y, Jia X, Lu F
Frontiers in physiology 2025;16:1607873
Frontiers in physiology 2025;16:1607873
Jiannao Pills alleviate depression-like behavior in chronic unpredictable mild stress-induced mice through NF-κB/NLRP3 pathway.
Pan J, Liu J, Fan Q, Gao S, Liang Y, Zhang L
Frontiers in pharmacology 2025;16:1606445
Frontiers in pharmacology 2025;16:1606445
Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway.
Pang Y, Tian L, Liu Y, Guo Y, Zhao J, Wang Y, Wang M, Zhao W
Frontiers in endocrinology 2025;16:1606326
Frontiers in endocrinology 2025;16:1606326
The function of CD164 in breast cancer and its possibility as a molecular biomarker: bioinformatics analysis and experimental validation.
Li M, Mao J, Wang G, Chen J, Hong J, Wang X, Liang B, Song D
Frontiers in immunology 2025;16:1601547
Frontiers in immunology 2025;16:1601547
IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.
Xue Z, Yang D, Jin Z, Li Y, Yu Y, Zhao X, Huang Y, Jia S, Zhang T, Huang G, Hou J
Frontiers in genetics 2025;16:1584095
Frontiers in genetics 2025;16:1584095
Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly.
Liu Q, Chen Q, Wei H, Tang B, Tian B, Ma Z, Gu Q, Su X, Dong Y, Shi W, Luo C
Frontiers in immunology 2025;16:1578416
Frontiers in immunology 2025;16:1578416
Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice.
Tang R, Jiang L, Ji Q, Kang P, Liu Y, Miao P, Xu X, Tang M
Frontiers in pharmacology 2025;16:1572906
Frontiers in pharmacology 2025;16:1572906
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
Yang X, Wang X, Li K, Deng Q, Hou Y, Xi G, Lu K, Liu Z, Bai Y, Wu J, Yu J, Zhang P
Frontiers in immunology 2025;16:1569210
Frontiers in immunology 2025;16:1569210
Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.
Yang J, Zhang H, Ni L, He J
Frontiers in pharmacology 2025;16:1567762
Frontiers in pharmacology 2025;16:1567762
Licochalcone D mitigates intracerebral hemorrhage-induced ferroptosis of neurons through COX2 inhibition.
Song J, Qiao H, Dong S, Tang J, Li B, Zhou X, Lv S, Lv R
Frontiers in pharmacology 2025;16:1566724
Frontiers in pharmacology 2025;16:1566724
Anticancer effects of zinc ion-mediated DNA demethylation in oesophageal squamous cell carcinoma.
Zhou B, Wang C, Huang Y, Yang X, Ye T, Shen L, Lv Q, Mao W, Zhao A
Frontiers in pharmacology 2025;16:1559675
Frontiers in pharmacology 2025;16:1559675
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
Xi P, Zeng D, Chen M, Jiang L, Zhang Y, Qin D, Yao Z, He C
Frontiers in immunology 2025;16:1546242
Frontiers in immunology 2025;16:1546242
Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer.
Zhang LT, Zhou Y, Wang T, Chen B, Cai Z, Wang S, Tong G
Frontiers in pharmacology 2025;16:1541820
Frontiers in pharmacology 2025;16:1541820
Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway.
Wu Y, Wang B, Mao X, Chen W, Akber Aisa H
Frontiers in pharmacology 2025;16:1526952
Frontiers in pharmacology 2025;16:1526952
Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways.
Xu Y, Ning L, Si Y, Li X, Wang R, Ren Q
Frontiers in endocrinology 2025;16:1526109
Frontiers in endocrinology 2025;16:1526109
Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.
Zhang C, Huang P, Cheng H, Yuan X, Zhou M, Liu Y, Liu T, Chen D, Xu Q, Cai J
Frontiers in pharmacology 2025;16:1509317
Frontiers in pharmacology 2025;16:1509317
Genipin attenuates oxidative damage in periodontal tissues by alleviating mitochondrial dysfunction and abnormal glucose uptake through inhibition of UCP2.
Deng Y, Fu R, Shang Y, Hu M, Xin X, Hou Y, Yu W, Liu X
Frontiers in pharmacology 2025;16:1446574
Frontiers in pharmacology 2025;16:1446574
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Wang Y, Chai C, Lin W, Cao J, Li Z, Jin Y, Xu Y, Zhang J, Qu Y, Zhan J, Zhao T, Chen Y, Gao M, Huang C, Li M
Theranostics 2025;15(14):6665-6685
Theranostics 2025;15(14):6665-6685
Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway.
Zhu Y, Tang Z, Lu Z, Gao D, Pan H, Jiang H, Zhang Z, Zhang H
Frontiers in oncology 2025;15:1698721
Frontiers in oncology 2025;15:1698721
CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis.
Lu Y, Yao M, Wang D, Higuchi D, Lu H, Shang H, Dong B, Zhang J, Jin R, Liu T
Frontiers in oncology 2025;15:1671797
Frontiers in oncology 2025;15:1671797
HOXB7 drives bladder cancer progression via H-Ras/ERK signaling: a potential therapeutic target and prognostic biomarker.
Chen X, Jiang K, Chen K, An Y, Wang Q, Chen X, Zhang P, Zhong Q, Sun F
Frontiers in oncology 2025;15:1645803
Frontiers in oncology 2025;15:1645803
SATB2 promotes radiation resistance of esophageal squamous cell carcinoma by regulating epithelial-to-mesenchymal transition via the Wnt/β-catenin pathway.
Lin C, Wu Y, Qian Y, Li J, He Y, Yu H, Xie C, Su H
Frontiers in oncology 2025;15:1543426
Frontiers in oncology 2025;15:1543426
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
Yao L, Gu C, Ge R, Zhang X, Meng X, Wang L, Peng D, Li G
Frontiers in oncology 2025;15:1529868
Frontiers in oncology 2025;15:1529868
NCYM facilitates cell proliferation and invasion in Wilms tumor by regulating SIX1/β-catenin axis.
Wang Z, Ning F, Tu L, Yao Y, He J, Zhao Y
American journal of clinical and experimental urology 2025;13(5):316-331
American journal of clinical and experimental urology 2025;13(5):316-331
BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.
Liu L, Xiong L, Peng H, Deng Q, Liu K, Xia S
PeerJ 2025;13:e19477
PeerJ 2025;13:e19477
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.
Xiao K, Li M, Mu Y, Sun Y, Wang S, Chen S, Ma J, Cao M, Yang Y, Shao H, Ding X, Cui G, Du Z
Frontiers in bioengineering and biotechnology 2025;13:1668524
Frontiers in bioengineering and biotechnology 2025;13:1668524
Fibroblast growth factor 19 regulates polycystic ovary syndrome progression via FGFR4-ERK-NRF2 pathway.
Qu J, Qiu M, Wang J, Chen Z, Chen M, Teng X, Li Y
Frontiers in cell and developmental biology 2025;13:1626938
Frontiers in cell and developmental biology 2025;13:1626938
Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic-reperfusion injury by targeting the NOX2/AMPK pathway.
Chen Y, Guan B, Lu J, Yan X, Huang C, Qiu Y, Li X, Sun X, Chen L, Li W, Mao W, Sun Z, Xu B, Li S, Chen C
Frontiers in cell and developmental biology 2025;13:1623846
Frontiers in cell and developmental biology 2025;13:1623846
SNHG12 downregulation induces follicular dysplasia by modulating the glycolysis of granulosa cell in polycystic ovary syndrome.
Yan S, Qu B, Chen Y, Wu Q, Ding J, Qiu H
Frontiers in cell and developmental biology 2025;13:1585987
Frontiers in cell and developmental biology 2025;13:1585987
Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage.
Peng Y, Guo Y, Yang X, Liu Y, Xu X, Chen J, Liu X, Xie Z, Yu Z, Wu D, Chen Z
Frontiers in chemistry 2025;13:1544616
Frontiers in chemistry 2025;13:1544616
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Cheng W, Wang C, Ma M, Zhou Y
Frontiers in cell and developmental biology 2025;13:1529901
Frontiers in cell and developmental biology 2025;13:1529901
Exploring the role of febuxostat's drug target XOR in erectile dysfunction: insights from human genetics and rat models.
Chen Z, Li Y, Meng C, Li X, Liao H, Li X, Zeng Y, Li X, Zhou T, Deng Q
Frontiers in medicine 2025;12:1674086
Frontiers in medicine 2025;12:1674086
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Lu B, He J, Pan S, Wei J, Li B, Cao N, Huang Y, Tian Y, Cheong N, Chen Y, Xu D, Li W
Frontiers in veterinary science 2025;12:1672417
Frontiers in veterinary science 2025;12:1672417
Effects of all-trans retinoic acid and oxygen concentration on the proliferation and differentiation of subcutaneous adipocytes in yak.
Yasenjian S, Shan S, Zhe Y, Zhang Y, Chai Z
Frontiers in veterinary science 2025;12:1643818
Frontiers in veterinary science 2025;12:1643818
Knockdown of annexin A2 enhances the host cell apoptosis induced by Eimeria tenella.
Wang J, Wang M, Wang Y, Xu M, Liu Y, Zheng M, Zhao R, Bai R, Zhao Y, Zhang L, Lv X, Yang Y, Guan W, Cui X
Frontiers in veterinary science 2025;12:1595384
Frontiers in veterinary science 2025;12:1595384
Effect of transport stress on apoptosis and autophagy in goat lung cells.
Zhuo Y, Hu Y, Jin Y, Ye T, Yang Y, Liu B, Zheng W, Ding S, Yang X, Zheng L, Hu W, Fang M, Yi W, Xing W
Frontiers in veterinary science 2025;12:1585008
Frontiers in veterinary science 2025;12:1585008
Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.
Dawa ZM, Zhai T, Liu CC, Fan HN
Frontiers in medicine 2025;12:1503472
Frontiers in medicine 2025;12:1503472
Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.
Liu T, Kong J, Li Z, Xi S, Liu L
Drug development research 2025 Sep;86(6):e70150
Drug development research 2025 Sep;86(6):e70150
SNORA33 Promotes Clear Cell Renal Cell Carcinoma Development and Resistance to Sunitinib Through Triggering the JAK/STAT Pathway.
Sun J, Zhao S, Ren X, Du Q, Chang Q, Guo W, Qiu L, Yang L, Zhang N, Zhao Z, Fan Y, Liu J
IUBMB life 2025 Sep;77(9):e70058
IUBMB life 2025 Sep;77(9):e70058
3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis.
Feng Y, Lin Z, Wang H, Men Z, Shen J, Ma X
Science China. Life sciences 2025 Sep;68(9):2707-2722
Science China. Life sciences 2025 Sep;68(9):2707-2722
Human Neural Progenitor Cell-Derived Exosomes Deliver miR- 100 - 5p Targeting NOX4 mRNA to Alleviate Oxidative Stress in Acute Ischemia Injury.
Zhao X, Gu C, Wang M, Huang S, Gong X, Kang M, Zhang T, Shen J, Yang X, Xi Y, Pan J
Molecular neurobiology 2025 Sep;62(9):12344-12359
Molecular neurobiology 2025 Sep;62(9):12344-12359
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1.
Yan H, Li H, Yin DH, Zhang ZZ, Zhang QY, Ren ZY, Hu Y, Zheng GY, Liu Y, Ma WY, Liu YN, Wang XX, Cai BZ, Chen HY
Acta pharmacologica Sinica 2025 Sep;46(9):2393-2406
Acta pharmacologica Sinica 2025 Sep;46(9):2393-2406
Brucine Inhibits Gastric Cancer via Activation of Ferroptosis Through Regulating the NF-κB Signaling Pathway.
Zhang B, Yu C, Zhang S, Zhang M
Journal of biochemical and molecular toxicology 2025 Sep;39(9):e70479
Journal of biochemical and molecular toxicology 2025 Sep;39(9):e70479
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Wang Z, Sun Y, Wang C, Yao J, Hao R, Wang Y, Sun H
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Bacterial cellulose membrane integrating phase-transited lysozyme nanofilm loaded with biguanides for dressing treatment of atopic dermatitis.
Lin J, Yu H, Huang Y, Yuan J, Wang C, Bai B
International journal of biological macromolecules 2025 Sep;323(Pt 1):147047
International journal of biological macromolecules 2025 Sep;323(Pt 1):147047
Integrative spatial multi-omics identifies the TEK receptor tyrosine kinase as a central biomacromolecule of endothelial-immune interactions in glioblastoma.
Yu Z, Zhou Q, Wang XA, Liu H, Shang R, Shen Y, Zhang J, Gao A, Liang H
International journal of biological macromolecules 2025 Sep;322(Pt 3):146964
International journal of biological macromolecules 2025 Sep;322(Pt 3):146964
Regulation of macrophage phenotypes via NF-κB/NLRP3 and HIF1α/p53 pathways by fuco-galactoglucan from Agrocybe aegerita.
Li X, Shui M, Zhang X, Tang H, Guo H, Gu F, Xu H, Han B, Kou Y
International journal of biological macromolecules 2025 Sep;322(Pt 2):146559
International journal of biological macromolecules 2025 Sep;322(Pt 2):146559
Modeling Mycobacterium tuberculosis pathogenesis in lung epithelial organoids reveals strain-specific host responses and intercellular crosstalk.
Zhang R, Yao F, Huang Y, Liu W, Liao S, He J, Li S, Wang Z, Li L, Zhang G
The Journal of biological chemistry 2025 Sep;301(9):110534
The Journal of biological chemistry 2025 Sep;301(9):110534
Imipramine Inhibits Osteosarcoma Invasion via Src Inactivation and Caspase-Dependent Apoptosis.
Liu YC, Fang CJ, Hsu LC, Hsu FT, Hu MH
Journal of cellular and molecular medicine 2025 Sep;29(17):e70761
Journal of cellular and molecular medicine 2025 Sep;29(17):e70761
LncRNA H19 and miR-138 modulate retinal neovascularization and associated pathological features in hypoxia-induced disease models.
Yu Y, Di Y, Li P, Nie Q, Chen X, Wang A, Ren K
Experimental eye research 2025 Sep;258:110512
Experimental eye research 2025 Sep;258:110512
The m6A transferase METTL3 regulates high glucose-induced proliferation and apoptosis of human lens epithelial cells through the lncRNA TUG1/KHSRP/p38MAPK signaling axis.
Li Y, Yao Z, Gao X, Niu Y, Gao Z, Jiang S
Experimental eye research 2025 Sep;258:110492
Experimental eye research 2025 Sep;258:110492
Inhibition of USP5 Attenuates Atherosclerosis by Suppressing PDCD4-Mediated Endothelial Dysfunction: Evidence from In Vitro HUVEC and In Vivo Models.
Chen Y, Wang Y, Wu T, Guo X, Bai X, Wang L, Yan P, Zheng Z, Xiao L, Li L
Cardiovascular toxicology 2025 Sep;25(9):1272-1287
Cardiovascular toxicology 2025 Sep;25(9):1272-1287
The Age-Associated Long Noncoding RNA lnc81 Regulates Ovarian Granulosa Cell Proliferation and Apoptosis Through TEAD2-CCN1/2 Pathway in Mice.
Ma Z, Luo R, Xue Y, Zheng L, Zhou C, Fang S, Hu N, Wang H, Cheng X, Luo T, Hu L
Journal of cellular physiology 2025 Sep;240(9):e70090
Journal of cellular physiology 2025 Sep;240(9):e70090
Mst1 inhibition mitigates steroid-induced femoral head osteonecrosis by modulating autophagy in bone microvascular endothelial cells.
Zhang Y, Jiang T, Li B, Sun G, Wang Y, Jiang Y, Hua P, Mu X, Wang W, Zhang Q
Biochemical pharmacology 2025 Sep;239:117081
Biochemical pharmacology 2025 Sep;239:117081
Benserazide‑mediated targeting hexokinase 2 enhances the cytotoxicity of cisplatin in non-small cell lung cancer cell models.
Wang K, Wang S, Shan W, Huang S, Fang T, Zhou Y, Liu L, Sha O, Tam KY
Biochemical pharmacology 2025 Sep;239:117071
Biochemical pharmacology 2025 Sep;239:117071
Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.
Chen G, Wei M, Zhao CY, Zhang AY, Su JB, Ni ZR, Cai WW, Hou B, Du B, Liu MH, Xu GW, Yang L, Xu AJ, Wen YY, Wang J, Zou H, Zhuang YY, Xing HY, He T, Li YF, Lu QB, Zhu J, Zhu XX, Li KL, Sun HJ
Free radical biology & medicine 2025 Sep;237:542-557
Free radical biology & medicine 2025 Sep;237:542-557
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Li D, Duan H, Jiang Z, Zhou C, Cao C, Ni M, He L, Zhu X, Jin L, Liu W, Gu L, Li H, Liu D, Zhao X, Zhao G, Li J
Free radical biology & medicine 2025 Sep;237:270-284
Free radical biology & medicine 2025 Sep;237:270-284
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Duan T, Sun L, Xi Y, Li C, Zhao Q, Xu L, Yang M, Liu C, Xiao L, Deng T, Sun L
Free radical biology & medicine 2025 Sep;237:147-159
Free radical biology & medicine 2025 Sep;237:147-159
ESCRT III-mediated lysosomal repair improve renal tubular cell injury in cisplatin-induced AKI.
Tian Z, Wu Y, Yi B, Li L, Liu Y, Zhang H, Li A
Autophagy 2025 Sep;21(9):1927-1944
Autophagy 2025 Sep;21(9):1927-1944
Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS).
Liang C, Chen M, Mu Z, Tian X, Zhao W, Hu Y, Su J
Biological trace element research 2025 Sep;203(9):4648-4658
Biological trace element research 2025 Sep;203(9):4648-4658
Bioactive ROS-responsive nanotherapeutics attenuate intermittent hypoxia-induced cognitive impairment via NRF2/KEAP1/HO-1 signaling.
Huang Y, Xie H, Liu L, Zhao H, Li B, Zhang F
Neurochemistry international 2025 Sep;188:105997
Neurochemistry international 2025 Sep;188:105997
Synergistic mechanisms of Banxia Xiexin decoction in overcoming chemoresistance and enhancing chemosensitivity in colorectal cancer.
Yue Y, Chen M, Qin Y, Qian Y, Cui T, Liu T, Su L, Li Z, Yan S
Fitoterapia 2025 Sep;185:106711
Fitoterapia 2025 Sep;185:106711
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Shen L, Xu J, Wang Y, Yao J, He X
Fitoterapia 2025 Sep;185:106688
Fitoterapia 2025 Sep;185:106688
USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice.
Su JB, Chen G, Sun QY, Fu X, Wu LX, Qiu HB, Lv ZL, Hu JY, Wang Y, Zhuang YY, Sun HJ, Lu QB, Zhang JR, Zhu XX
Metabolism: clinical and experimental 2025 Sep;170:156326
Metabolism: clinical and experimental 2025 Sep;170:156326
Synthesis and biological evaluation of diosgenin derivatives as potential anti-breast cancer agents.
Huang X, Wang D, Shi X, Su W, Chen Y, Sun Y, Ma T, Zhu W, Liu Q, Ma L, Sun J, Fan S, Ma Y, Wang W, Zhang J
Bioorganic chemistry 2025 Sep;164:108809
Bioorganic chemistry 2025 Sep;164:108809
Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro.
Zhang L, Kong HW, Song XY, Sheng LS, Huang NN, Liu Y, Sun R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157037
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157037
Shoutai pill exhibits anti-miscarriage efficacy through tripartite modulation of gut microbiota, systemic metabolism, and maternal-fetal immunity: A multi-omics analysis.
Xu W, Li B, Ge Z, Li L, He X, Chen X, Chu C, Lv G, Chen S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156991
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156991
Ershiwuwei Shanhu pills alleviates cerebral ischemia injury in rats by regulating endoplasmic reticulum stress through GRP78/XBP1/CHOP pathway.
Han M, Fu J, Suonan Z, Wang Z, Bai B, Liang Y, Song Y, Zhang J, Tang C, Kuang T, Fan G, Cui Y, Du H, Li X, Tuo S, Zhong K, Kong B, He W, Nhamdriel T, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156969
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156969
DAPK1 induces motor neuron apoptosis in hSOD1(G93A)-linked amyotrophic lateral sclerosis via regulating the Xiap/JNK pathway.
Su X, Tan X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Feng H
Molecular and cellular neurosciences 2025 Sep;134:104029
Molecular and cellular neurosciences 2025 Sep;134:104029
Protective Effects of Ganoderma Triterpenoids Supplementation Against Myocardial Injury in Exhaustion Exercise Mice via Regulation of the Keap1/Nrf2/HO-1 Pathway.
Li J, Zhang L, Qin G, Liu W, Xu X, Zhu J, Zhao S, Qiu T
Food science & nutrition 2025 Sep;13(9):e70937
Food science & nutrition 2025 Sep;13(9):e70937
Knocking Down SKA1 Inhibits Hepatocellular Carcinoma Progression via Apoptosis: Integrating Single-Cell Transcriptomics With In Vivo and In Vitro Validation.
Luo Q, Zhang Q, Zheng Z, Jiang X
BioFactors (Oxford, England) 2025 Sep-Oct;51(5):e70044
BioFactors (Oxford, England) 2025 Sep-Oct;51(5):e70044
Protective effects of Ginkgolide B on myocardial ischemia reperfusion injury: role of the GAS6/Axl signaling pathway.
Liu H, Lei W, Ren Y, Tian J, Wang D, Tang Y, Zhou S, Huang C, Huang G, Yang Y, Liang Z
Chemico-biological interactions 2025 Sep 5;418:111607
Chemico-biological interactions 2025 Sep 5;418:111607
LncRNA LOXL1-AS1 promotes ovarian cancer progression by enhanced BRIP1 mRNA stability.
Wan S, Su C, Ding J, Liu J, He L, Liu L, Peng Q, Ni G, Zhu W
Medical oncology (Northwood, London, England) 2025 Sep 30;42(11):504
Medical oncology (Northwood, London, England) 2025 Sep 30;42(11):504
Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H(2)O(2)-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.
Yang RL, Yang YB, Wei HX, Zhang M, Yang K, Zhao YJ, Yan W, Yang Y, Zhang T
European journal of medical research 2025 Sep 30;30(1):919
European journal of medical research 2025 Sep 30;30(1):919
CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway.
Xu C, Li Z, Shan Y, She C, Yang Y, Zhou T, Xie Y, Ni B, Meng C, Shen G, Fu B, Sheng G, Wu L, Pei J, Zhao T, Gao S, Wang H, Deng C, Wang K, Chang A, Huang C, Shi L, Yang S, Yu J, Hao J, Wang X
Cancer biology & medicine 2025 Sep 30;22(12):1558-77
Cancer biology & medicine 2025 Sep 30;22(12):1558-77
Neochlorogenic acid inhibits gastric cancer cell growth through apoptosis and cell cycle arrest.
Sun W, Li Y, Xu M, Guan H, Shi R, Li S
Translational cancer research 2025 Sep 30;14(9):5297-5310
Translational cancer research 2025 Sep 30;14(9):5297-5310
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease.
Wang X, Zhang L, Tang R, Zhang W, Xie Y, Li K
Pharmaceuticals (Basel, Switzerland) 2025 Sep 27;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 27;18(10)
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
Wang B, Wang J, Qi C, Gao C, Wang Y, Zan Y, Tan Y, Wu Z, Jiang J, Suo J, Zhang J, Peng Z
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Guo A, Chen X, Bai Y, Dai Y, Yue H
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Mechanisms of Saposhnikovia divaricata in attenuating NaAsO(2)-induced neural injury via the PI3K/AKT pathway.
Gu D, Chen XL, He HL, Xia M, Huang JY, He GH, Wang XY, Chen YY, Kang WR, Sun BF, Liu XH, Zhou W, Zhuo XL, Pan JG
Scientific reports 2025 Sep 26;15(1):33303
Scientific reports 2025 Sep 26;15(1):33303
Self-Assembling Amphiphilic Peptides Target the VDAC1-Hexokinase-II Complex to Induce Apoptosis in Cervical Carcinoma Cells.
Sun W, Angelova A, Han X, Wang X, Angelov B, Chen Q, Li N, Zou A
Journal of medicinal chemistry 2025 Sep 25;68(18):18857-18868
Journal of medicinal chemistry 2025 Sep 25;68(18):18857-18868
Protective effects of Dachengqi Decoction in sepsis-associated liver injury based on network pharmacology analysis and experimental validation.
Liu Y, Lei Y, Shang L, Yu Z, Wang L, Zhou J, Pan G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120450
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120450
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Yang Z, Ji P, Zhang W, Li C, Wu F, Hua Y, Wei Y, Cao Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Xuebijing alleviates sepsis-induced acute lung injury by inhibiting alveolar epithelial cell apoptosis via cAMP/PKA signaling pathway.
Ren T, Chen Q, Xu J, Jiang H, Guo T, Wu Y, Xu Y, Dai L
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120370
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120370
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Xia C, Zhang J, Chen H, Jiang W, Zhou S, Zheng H, Sun W
International immunopharmacology 2025 Sep 23;162:115121
International immunopharmacology 2025 Sep 23;162:115121
Epalrestat, an aldose reductase inhibitor, mitigates doxorubicin-induced cardiotoxicity by inhibiting glycometabolism.
Zhu J, Wang H, Guan Y, Wang Y, Tan W, Wang J
International immunopharmacology 2025 Sep 23;162:115106
International immunopharmacology 2025 Sep 23;162:115106
7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway.
Tian Z, Tan TT, Hu YW, Yao JT, Kang XT, Zhou JY, Jia DX, Li QL, Liang RJ, Zhao LM, Zhu H, Zhao J, Hang PZ
Toxicology and applied pharmacology 2025 Sep 22;505:117578
Toxicology and applied pharmacology 2025 Sep 22;505:117578
Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.
Li T, Zhu K, Tong H, Sun Y, Zhu J, Qin Z, Chen J, Wu L, Zhang X, Wang A, Gou X, Yin H, He W
Journal of experimental & clinical cancer research : CR 2025 Sep 2;44(1):265
Journal of experimental & clinical cancer research : CR 2025 Sep 2;44(1):265
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
Jiang Y, Shi Y, Lv M, Wang T, Wang P, Yuan X, Gao F, Ma B
Cell biology and toxicology 2025 Sep 2;41(1):129
Cell biology and toxicology 2025 Sep 2;41(1):129
Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis.
Wang J, Qing B, Gu L, Chen H, Chen Y, Tang Y, Ge Z, Hu R, Yuan Y, Xia Z
Journal of translational medicine 2025 Sep 2;23(1):986
Journal of translational medicine 2025 Sep 2;23(1):986
Curcumin Inhibits Protease Activated Receptor 2-Induced ERK Phosphorylation Calcium Mobilization and Anti-Apoptotic Signaling in Inflammation-Driven Colorectal Cancer Cells.
Patnaik R, Varghese R, Al-Kabani A, Jannati S, Banerjee Y
Cells 2025 Sep 16;14(18)
Cells 2025 Sep 16;14(18)
Molecular engineering strategies for fabricating type-I mitochondria-targeted aggregation-induced emission photosensitizers for apoptosis-ferroptosis synergistically boosting photodynamic therapy.
Wang S, Qiu Y, Yu L, Lu K, Du B, Zhang J, Gong H, Ren A, Chen M, Zhang H, Zang XF, Ye X, Cai L, Quan YY, Huang ZS
Journal of colloid and interface science 2025 Sep 15;694:137680
Journal of colloid and interface science 2025 Sep 15;694:137680
Gremlin 1 regulates granulosa cell apoptosis through the TGF-β/SMAD signaling pathway during bovine follicular atresia.
Xu Y, Liu M, Yang T, Zhao B, Li Y, Wang J, Wang Y, Lin P, Chen H, Wang A, Jin Y, Tang K
Molecular and cellular endocrinology 2025 Sep 15;607:112605
Molecular and cellular endocrinology 2025 Sep 15;607:112605
Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.
Liu G, Kuang S, Zhong W, Yang A, Huang X, Xie Y, Zhang X, Li Y, Qin Q, Liu G
Journal of pharmaceutical and biomedical analysis 2025 Sep 15;263:116899
Journal of pharmaceutical and biomedical analysis 2025 Sep 15;263:116899
MSTRG.118323.5 targets BAG5 as a miR-200-y sponge to regulate Sertoli cells apoptosis via PI3K/AKT/mTOR pathways of Bactrian camels.
Nan J, Liu Y, Wang R, Yan Q, Zhang Y, Wang Q, Zhao X
International journal of biological macromolecules 2025 Sep 11;328(Pt 2):147638
International journal of biological macromolecules 2025 Sep 11;328(Pt 2):147638
Evodiamine protects against cardiac remodeling in heart failure through modulation of calcium signaling and CD47.
Guo L, Niu H, Li J, Shao X, Li N, Sun Y, Ma Y, Wang H
Biochemical and biophysical research communications 2025 Sep 1;777:152168
Biochemical and biophysical research communications 2025 Sep 1;777:152168
Polyethylene terephthalate (PET) microplastics induced male reproductive toxicity in mice by activating the p38-MAPK pathway.
Zhang X, Ma T, Sun J, Fang Y, Wang Y, Li X, Zhao Z, Su N, Liu M, Bai J, Liu J, Wu J
Ecotoxicology and environmental safety 2025 Sep 1;302:118756
Ecotoxicology and environmental safety 2025 Sep 1;302:118756
Protective role of RGS2 in PM2.5-induced ovarian injury in rats: Modulation of Gq/11 signaling to maintain granulosa cell [Ca(2 +) ]i stability.
Ma Z, Du X, Zhao C, Sun Y, Jia Y, Liang X, Yu X, Gao Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118537
Ecotoxicology and environmental safety 2025 Sep 1;302:118537
PADI1 aggravates endoplasmic reticulum stress in trophoblast cells by inhibiting the FAK-ERK signaling pathway.
Ning J, Yang S, Gao F, Wang L, Lin Z, Cheng D, Fan K
Tissue & cell 2025 Oct;96:102976
Tissue & cell 2025 Oct;96:102976
Dectin-1 Drives Diabetic Retinopathy via Inducing Microglia-Mediated Inflammation and Blood-Retinal Barrier Breakdown.
Zhang L, Zhang S, Li Y, Yang Z, Hu W, Bai H, Zhou W, Wang Z, Li M, Zhang S, Liao R
Developmental neurobiology 2025 Oct;85(4):e22997
Developmental neurobiology 2025 Oct;85(4):e22997
Sargentodoxa cuneata suppresses lung adenocarcinoma progression by enhancing cytotoxic CD8(+) T activity through the ACY1/ARG2 interaction.
Xu J, Yuan L, Wu H, Xu H, Yang B, Hu F
Cytotechnology 2025 Oct;77(5):185
Cytotechnology 2025 Oct;77(5):185
POM121 induces chemoresistance toward cisplatin in non-small cell lung cancer.
Li J, Sun W, Yan D, Hui K, Liu Y
Cytotechnology 2025 Oct;77(5):180
Cytotechnology 2025 Oct;77(5):180
Glycyrrhizic Acid Inhibits Hippocampal Neuron Apoptosis by Activating the PI3K/ AKT Signaling Pathway.
Fu G, Kang X, Lin S
Biochemical genetics 2025 Oct;63(5):4366-4381
Biochemical genetics 2025 Oct;63(5):4366-4381
Exercise Training Promotes Neural Remodeling and Vascular Regeneration in Cerebral Ischemic Rats Through the JNK/c-jun Signaling Pathway.
Zhao Z, Chen X, Zhuang Z, Chen J, Zheng Z, Wu W, Wu Z, Lin Q, Chen M, Liu J, Liu N, Chen R, Chen H
Molecular neurobiology 2025 Oct;62(10):13103-13118
Molecular neurobiology 2025 Oct;62(10):13103-13118
Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.
Yang X, Li K, Chen L, Wang L, Wang X, Lu K, Bai Y, Hou Y, Hou J, Wang C, Cheng X, Oldam J, Yu J, Wu J, Sun B
Molecular neurobiology 2025 Oct;62(10):12907-12923
Molecular neurobiology 2025 Oct;62(10):12907-12923
Early cardioprotective effects of SGLT2i on hypertensive cardiac remodeling via STIM1/Orai1-dependent calcium signaling: beyond blood pressure control.
Wu J, Jia Z, Wu X, Xue Y, Zheng P, Wang H, Zhao R
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):245-259
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):245-259
Chlorogenic Acid Improves Salicylic Acid-Induced Cochlear Injury by Reducing Oxidative Stress and Inflammatory Response Through TLR4/NF-κB Signalling Pathway.
Lin Y, Li L, Cheng J
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70067
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70067
Ribociclib derivative Rib-CA suppresses breast cancer progression via p53-dependent apoptosis.
Song M, Zhou Y, Yu X, Zhang B, Wang S, Asan K, Yang Z, Lin H, Wang J, Song X, Jiang Y, Chen S, Ji J, XiujunWang, Mou Y
Toxicology and applied pharmacology 2025 Oct;503:117475
Toxicology and applied pharmacology 2025 Oct;503:117475
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
Ren Q, Pan Y, Tian Z, Jiao G, Liu X
Cell biology international 2025 Oct;49(10):1245-1261
Cell biology international 2025 Oct;49(10):1245-1261
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
Guo N, Xia Y, He N, Zhang L, Liu J
Inflammation 2025 Oct;48(5):3282-3299
Inflammation 2025 Oct;48(5):3282-3299
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
Wang Y, Liu Y
Hearing research 2025 Oct;466:109386
Hearing research 2025 Oct;466:109386
OTUD1 deficiency attenuates myocardial ischemia/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation.
Luo Y, Li WX, Zheng QS, Yan JQ, Yang YD, Shen SR, Zhang QH, Liang G, Wang Y, Chen DD, Hu X, Luo W
Acta pharmacologica Sinica 2025 Oct;46(10):2649-2662
Acta pharmacologica Sinica 2025 Oct;46(10):2649-2662
Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation.
Kao GY, Xu Y, Zhang Y, Xu G
Current medical science 2025 Oct;45(5):1055-1067
Current medical science 2025 Oct;45(5):1055-1067
miR-140-3p Alleviates Pulmonary Arterial Smooth Muscle Cell Dysfunction via MAP2K6/p38 Pathway.
Chen L, Zhang JY, Huang L, Jin LL, Xie WP, Wang H, He MY, Kong H
Journal of biochemical and molecular toxicology 2025 Oct;39(10):e70532
Journal of biochemical and molecular toxicology 2025 Oct;39(10):e70532
Cinobufagin induced myocardial cell toxicity in H9c2 cells via inhibiting histone methyltransferase SMYD1 expression.
Wu H, Wang C, Zhang H, Zhang Q, Wang J, Wang Y, Chen L, Cheng S, Ying J, Xiang Y, Cheng Y, Ye J, Zhang L
Toxicology mechanisms and methods 2025 Oct;35(8):1089-1102
Toxicology mechanisms and methods 2025 Oct;35(8):1089-1102
Cationic microbubble loading hSIRT3 and hTIMP3 optimize cardiac-targeted delivery and myocardial protection in the porcine MI/R model.
Cai P, Chen K, Qin X, Jiang X, Jiao X, Liu K, Guo E, Li Z, Qiu X, Liu C, Sun L, Chuai J, Wu J, Chen W, Tian H
Materials today. Bio 2025 Oct;34:102234
Materials today. Bio 2025 Oct;34:102234
Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression.
Lee C, Huang S, Liu H, He X, Hao Y, Zeng L, Li Y, Lv Z, Xu Y, Guo R
Materials today. Bio 2025 Oct;34:102122
Materials today. Bio 2025 Oct;34:102122
Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration.
Miao G, Fortier TM, Liu H, Schafer DP, Fitzgerald KA, Mao J, Baehrecke EH
Nature structural & molecular biology 2025 Oct;32(10):2046-2059
Nature structural & molecular biology 2025 Oct;32(10):2046-2059
Quercetin induces immunogenic cell death against gastric cancer by targeting NR3C1.
Liu T, Wang Y, Peng M, Qi F, Liu Y, Ding H, Chen F
Toxicon : official journal of the International Society on Toxinology 2025 Oct;265:108477
Toxicon : official journal of the International Society on Toxinology 2025 Oct;265:108477
Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system.
Chen Y, Shen R, Zhou X, Xu D, Wu Q, Zhang J, Fang J
Free radical biology & medicine 2025 Oct;238:235-245
Free radical biology & medicine 2025 Oct;238:235-245
PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.
Zhang Z, Guo X, Liu Y, Ke P, Meng Y, Gu J, Hu L, Yuan Z, Duan R, Luo J, Xiao F
Free radical biology & medicine 2025 Oct;238:1-16
Free radical biology & medicine 2025 Oct;238:1-16
CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis.
Hua C, Zhang G, Yu W, Zhou J, Ru L, Xue G, Zheng L, Wang M, Wang Y, Yu D, Wang Q, Liu J, Wang R, Deng W, Tang R, Guo W
Pharmacological research 2025 Oct;220:107911
Pharmacological research 2025 Oct;220:107911
Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.
Chen W, Liu S, Zhou Y, Liu B, Wang W, Chen C, Lou Z, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Ran R, Gong CY, Wu ZL, Zhang SB, Zhang K, Zhou WM, Song W, Dong H, Shi YQ, Zhou KS, Zhang HH
The American journal of pathology 2025 Oct;195(10):1905-1920
The American journal of pathology 2025 Oct;195(10):1905-1920
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Wang M, Han Q, Zhang X, Dong X, Ran J, Wei F, Luo Y, Sun X
Chinese herbal medicines 2025 Oct;17(4):756-767
Chinese herbal medicines 2025 Oct;17(4):756-767
Hecogenin‑nitrogen mustard hybrids with improved anti-breast cancer activity: Design, synthesis, and biological evaluation.
Su W, Huang X, Ji X, Shi X, Song Y, Ma L, Zhu W, Wang X, Lin S, Ma Y, Wang W, Zhang J, Han C
Bioorganic chemistry 2025 Oct;165:109032
Bioorganic chemistry 2025 Oct;165:109032
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Zhao L, Wang J, Han Y, Wang Q, Yang W, Zhang Y, Lin Z, Zhu L, Piao J
Bioorganic chemistry 2025 Oct;165:109002
Bioorganic chemistry 2025 Oct;165:109002
Dihydrocapsaicin attenuates oxidative stress and apoptosis in acute myocardial infarction via promoting Raf-1/ASK1 complex formation.
Chen Y, Yu J, He H, Xu W, Yi B, Lin X, Yu Q, Lin Z, Lin J, Lin C, Cai C, Huang K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157126
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157126
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p/ACSL4 axis.
Feng J, Miao H, Xiao Z, Xu L, Wang Y, Cao X, Wang J, Wu Z, Xia P, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157113
Silibinin attenuates 3-nitropropionic acid-induced ovarian toxicity by alleviating oxidative stress and granulosa cell apoptosis.
Gai Y, Wu W, Wang H, Li Y, Li C, Wang Y, Zhao Y, Hu J, Luan X
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109027
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109027
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano-Fe(3)O(4) in spermatogonial GC-1 cells.
Cheng C, Cui Y, Wang Y, Huang J, Ma J, Luo T, Chen W
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109020
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109020
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
He Z, Feng YD, Zhang YX, Gao X, Liu JJ, Liu S, Wu GQ
Cellular signalling 2025 Oct;134:111932
Cellular signalling 2025 Oct;134:111932
Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.
Wang H, Jia Y, Ma B, Gao T, Wei H, Li D, Gu J, Chen O, Yue S
Cellular signalling 2025 Oct;134:111889
Cellular signalling 2025 Oct;134:111889
Radioprotective Efficacy of Jujube Aqueous Extract and Arbutin: Synergistic Antioxidant and Anti-Apoptotic Mechanisms in Radiation Injury.
Wang L, Yang H, Zhou X, Zhao Y, Li L, Wang N
Food science & nutrition 2025 Oct;13(10):e71073
Food science & nutrition 2025 Oct;13(10):e71073
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Gan H, Gong M, Wang L, Huang X, Chen Y, Hu Z, Li X, Zeng Q
Food science & nutrition 2025 Oct;13(10):e71064
Food science & nutrition 2025 Oct;13(10):e71064
(-)-Epigallocatechin Gallate Ameliorates Chronic Stress-Induced Depression-Like Behavior in Rats by Inhibiting the NF-κB/Caspase-1 Signaling Pathway and Reducing IL-1β and IL-18 Expression.
Wu G, Xu J, Wu W, Jin J, Li S, Huang Y, Zhang Z, Hu Y, Zhang Y, Liu Y, Xu Y, Zheng M, Xu C, Lu W, Wu H, Hu L
Food science & nutrition 2025 Oct;13(10):e70961
Food science & nutrition 2025 Oct;13(10):e70961
Glucose Deprivation-Induced Disulfidptosis via the SLC7A11-INF2 Axis: Pan-Cancer Prognostic Exploration and Therapeutic Validation.
Song Z, Yao Q, Huang L, Cui D, Xie J, Wu L, Huang J, Zhai B, Liu D, Xu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e08556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e08556
BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.
Peng X, Li Y, Tang F, Ma Y, Bai J, Li L, Zhang L
Cancer science 2025 Oct;116(10):2657-2676
Cancer science 2025 Oct;116(10):2657-2676
Arbutin improves lung injury in chicks induced by Mycoplasma gallisepticum infection.
Wan Z, Liu T, Cheng A, Li H, Lin R, Zhu E, Huang Y, Liu S, Tang Y, Shan C, Cheng Z
Poultry science 2025 Oct;104(10):105485
Poultry science 2025 Oct;104(10):105485
Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis.
Yichun C, Wen D, Weimeng J, Xin F, Fangyun S
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251404066
Dose-response : a publication of International Hormesis Society 2025 Oct-Dec;23(4):15593258251404066
Transcriptomic Investigation of FoxM1-Mediated Neuroprotection by hAEC-Derived Exosomes in an In Vitro Ischemic Stroke Model.
Wang D, Liu J, Wu L, Yang X, Fang Z, Sun Z, Chen D
Biology 2025 Oct 7;14(10)
Biology 2025 Oct 7;14(10)
Eimeria tenella AMA1 regulates host cell apoptosis through the mitochondrial pathway and the death receptor pathway.
Lv X, Wang L, Dong S, Yang Y, Zhang X, Xu T, Cui K, Niu Z, Zhao W, Bai R, Zhang L, Zheng M
Microbiology spectrum 2025 Oct 7;13(10):e0041625
Microbiology spectrum 2025 Oct 7;13(10):e0041625
Development of a CD9-Targeted Radiopharmaceutical for Imaging and Radionuclide Therapy in CD9-Positive Glioma.
Fan L, Shi X, Jiang H, Chen W, Liang M, Wang G, Li W, Wang F, Zhu R, Zhang M
Molecular pharmaceutics 2025 Oct 6;22(10):6368-6380
Molecular pharmaceutics 2025 Oct 6;22(10):6368-6380
Anti-ovarian cancer effects of forsythiaside A: insights from in vitro and in vivo studies.
Guan H, Li Y, Xu M, Sun W, Shi R, Li S
Translational cancer research 2025 Oct 31;14(10):6429-6441
Translational cancer research 2025 Oct 31;14(10):6429-6441
Reversal of Myofibroblast Apoptosis Resistance and Collagen Deposition by Phaseoloidin-Induced Autophagy Attenuates Pulmonary Fibrosis.
Li S, Qian J, Deng L, Liu W, Tang S, Xie W
Biomedicines 2025 Oct 31;13(11)
Biomedicines 2025 Oct 31;13(11)
Tanshinone IIA inhibits heat-induced growth of p53-mutant Huh-7 hepatocellular carcinoma by modulating osmotic homeostasis and glycolysis through targeting ALDH7A1.
Li H, Ju S, Wang J, Kuang D, Chen P, Zhang M, Qian R, Liang C, Han D, Duan X
Cell death discovery 2025 Oct 31;11(1):493
Cell death discovery 2025 Oct 31;11(1):493
Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway.
Lv M, Sun Q, Yu Y, Yu D
International immunopharmacology 2025 Oct 30;164:115394
International immunopharmacology 2025 Oct 30;164:115394
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Tsopmejio ISN, Tang S, Gao XF, Liu Z, Li XD, Qi MH, Zhu HY, Wang Z, Li W
International immunopharmacology 2025 Oct 30;164:115378
International immunopharmacology 2025 Oct 30;164:115378
3-n-butylphthalide improves cerebral ischemia/reperfusion injury by regulating neuronal mitochondrial biogenesis via AMPK/PGC-1α signaling pathway.
Li J, Zhu X
International immunopharmacology 2025 Oct 30;164:115343
International immunopharmacology 2025 Oct 30;164:115343
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Li H, Ouyang J, Zhang Y, Zhang Z, Sun M, Liu R, Qian C
Scientific reports 2025 Oct 29;15(1):37897
Scientific reports 2025 Oct 29;15(1):37897
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Ma X, Han L, Xu M, Feng Y, Liu C, Zhao Y, Zhang M, Xu G, Sun X
Current issues in molecular biology 2025 Oct 28;47(11)
Current issues in molecular biology 2025 Oct 28;47(11)
Mesenchymal stem cells inhibit mitochondrial fission by upregulating armadillo repeat containing 1, ameliorating oxidative stress in renal fibrosis.
Li T, Guo C, Liu Q, Jing F, Zhao M, Xiong H, Li C, Zhang W, Chen B
Stem cell research & therapy 2025 Oct 28;16(1):584
Stem cell research & therapy 2025 Oct 28;16(1):584
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.
Zhang Q, Wang J, He Y, Zhang K, Hong W, Han T
Journal of clinical and translational hepatology 2025 Oct 28;13(10):847-856
Journal of clinical and translational hepatology 2025 Oct 28;13(10):847-856
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Zhang X, Cui J, Sun J, Wang F, Fan B, Lu C
International journal of molecular sciences 2025 Oct 24;26(21)
International journal of molecular sciences 2025 Oct 24;26(21)
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice.
Zhu XX, Meng XY, Zhang AY, Zhao CY, Wei YT, Wen YY, Su JB, Fu X, Chen G, Xu AJ, Wang MY, Ji LM, Bao N, Bao ZY, Li N, Lu QB, Sun HJ
Nature communications 2025 Oct 24;16(1):9436
Nature communications 2025 Oct 24;16(1):9436
Fecal microbiota transplantation alleviated heat-induced colonic tissue damage, epithelial apoptosis, and oxidative stress.
Liu X, Liu C, Qian X, Zhang S, Yao Z, Chai Y, Shi Q, Yang W, Wang Q, Zhang L, Zeng X, Liu C, Wu Y, Sun Q
Applied and environmental microbiology 2025 Oct 22;91(10):e0097625
Applied and environmental microbiology 2025 Oct 22;91(10):e0097625
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice.
Wang P, Chen Y, Jiao Y, Zhu Y, Wang M, Ji D, Zou W, Cao Y, Liu Y, Liang D
Chemico-biological interactions 2025 Oct 22;420:111646
Chemico-biological interactions 2025 Oct 22;420:111646
Cephalomannine as in vitro and in vivo anticancer agent in mesothelioma cells: mechanisms of action.
Morani F, Dell'Anno I, Daga A, Doccini S, Bisceglia L, Gemignani F, Landi S
BMC cancer 2025 Oct 22;25(1):1625
BMC cancer 2025 Oct 22;25(1):1625
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Yu C, Wei X, Wang J, Wang L, Wang J
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Stigmasterol improves diabetic retinopathy by inhibiting VAMP7-mediated autophagy/mitophagy.
Wang Q, Zhang P, Ji F, Li Y, Lu P
Biochemical and biophysical research communications 2025 Oct 20;785:152653
Biochemical and biophysical research communications 2025 Oct 20;785:152653
TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.
Zhang X, Cheng S, Li W, Xu X, Huang X, Chen Z, Li Q, Huang W, Zhang L, Ouyang M
Cell communication and signaling : CCS 2025 Oct 2;23(1):414
Cell communication and signaling : CCS 2025 Oct 2;23(1):414
CDK11 Promotes Paclitaxel Resistance in Cervical Cancer by Regulating LATS1-Mediated Hippo Signaling Pathway Through Phosphorylation of NF2.
Zhang Y, Lu J, Qi M, Zhang X, Ou D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71085
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71085
PTEN-L dephosphorylates Parkin and Ub Ser65 to aggravate mitophagy dysfunction in prion disease cell models.
Li X, Li J, Gou F, Dai Y, Zhao M, Wang D, Sun Z, Wen P, Wang J, Fan Q, Ma T, Wang X, Zhao D, Yang L
Life sciences 2025 Oct 15;379:123860
Life sciences 2025 Oct 15;379:123860
Structural elucidation of an unusual acid heteropolysaccharide with moieties of glucuronogalactoarabinan and glucuronoarabinogalactan from young shoots of Aralia elata (Miq.) Seem.
Liang J, Ji MC, Jiang SL, Ban XT, Liu X, Shang XW, Zhang Y, Huang YX, Kuang HX, Xia YG
Carbohydrate polymers 2025 Oct 15;366:123794
Carbohydrate polymers 2025 Oct 15;366:123794
Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.
Zhao Q, Wu J, Yao J, Liu Z, Li C, Sun Q
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2025 Oct 15;339:126183
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2025 Oct 15;339:126183
Nitrite and microcystins co-exposure triggers PINK1-mediated mitophagy in spermatogonia.
Wang F, Fu Y, Liu H, Du X, Meng R, Ge K, Liang X, Yang J, Wang X, Guo F, Guo H, Zhang H
Ecotoxicology and environmental safety 2025 Oct 15;305:119239
Ecotoxicology and environmental safety 2025 Oct 15;305:119239
Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.
Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Ecotoxicology and environmental safety 2025 Oct 15;305:119228
Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.
Yang N, Li Y, Zhang J, Gao X, Zhang P, Li W
European journal of medical research 2025 Oct 15;30(1):975
European journal of medical research 2025 Oct 15;30(1):975
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Zhang Y, Wang YP, Guo S, Li TT, Wang QY, Zhang X, Zheng YM, Wen YQ, Meng FH, Zhang TJ
European journal of medicinal chemistry 2025 Oct 15;296:117895
European journal of medicinal chemistry 2025 Oct 15;296:117895
Nephroprotective mechanism of Kunkui Baoshen decoction in diabetic kidney disease: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway.
Song SY, Shan CC, Zhou PP, Xu WL, Tan Y, Zhou XQ, Huang LJ, Yan QH, Yu JY
World journal of diabetes 2025 Oct 15;16(10):109568
World journal of diabetes 2025 Oct 15;16(10):109568
Isorhynchophylline alleviates preeclampsia via PI3K/AKT/mTOR-mediated trophoblast oxidative stress inhibition.
Wang J, Li X, Zhu Y, Zhang X, Ye C, Zhuang Q, Wang Z, Liu D, Zhao G
European journal of pharmacology 2025 Oct 15;1005:178076
European journal of pharmacology 2025 Oct 15;1005:178076
EGR1 Mediates Riluzole-Induced Apoptosis in Osteosarcoma via the Yap/p73-Bax Signaling Axis.
Azeem SM, ChandThakuri S, Rao PP, Abbasi T, McFarlane J, Munira R, Porshe S, Rajasekhar VK, Healey JH, Mahajan SS
bioRxiv : the preprint server for biology 2025 Oct 15;
bioRxiv : the preprint server for biology 2025 Oct 15;
Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice.
Otani N, Oue T, Kobayashi Y, Kobayashi H, Tomita K, Kubo T
Biomedicines 2025 Oct 11;13(10)
Biomedicines 2025 Oct 11;13(10)
Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy.
Chen Z, Fang XG, Jia LJ, Feng Y, Cheng JH, Luo S, Wen S, Wei JR, Ma SN, Guo XR, Luo J
International immunopharmacology 2025 Oct 10;163:115247
International immunopharmacology 2025 Oct 10;163:115247
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy.
Lu M, Ye X, Deng X, Jiao F, Ren H, Xing Y
International immunopharmacology 2025 Oct 10;163:115240
International immunopharmacology 2025 Oct 10;163:115240
Long noncoding RNA ENST00000458139 promotes mitochondrial dysfunction and apoptosis of podocytes in diabetic kidney disease through binding with SNRPA1.
Yang M, Fan X, Lang Y, Hu J, Wang Q, Shen N, Zhang D, Chai S, Wang R, Lv Z
International immunopharmacology 2025 Oct 10;163:115232
International immunopharmacology 2025 Oct 10;163:115232
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Tong Y, Li Y, Bi Y, Liu Y, Peng X, He B, Wang X
Life sciences 2025 Oct 1;378:123830
Life sciences 2025 Oct 1;378:123830
Mangiferin targets PFKFB3 to inhibit glioblastoma progression by suppressing glycolysis and PI3K/AKT/mTOR signaling.
Xia J, Li X, Yao J, Song D, Gu Z, Zheng G, Tu C
Brain research bulletin 2025 Oct 1;230:111520
Brain research bulletin 2025 Oct 1;230:111520
Inhibition of DYRK1A can alleviate MPTP/MPP(+)-induced neuronal apoptosis and mitochondrial damage.
Cai Q, Xia H, Li P, Yao Y, Luo Q, Yang X
Brain research bulletin 2025 Oct 1;230:111516
Brain research bulletin 2025 Oct 1;230:111516
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.
Jiang Y, Lv M, Fan H, Shi Y, Wang T, Wang P, Yuan X, Gao F, Ma B
Animal models and experimental medicine 2025 Nov;8(11):2053-2068
Animal models and experimental medicine 2025 Nov;8(11):2053-2068
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
BFGF alleviates diabetic endothelial dysfunction by downregulating Endoplasmic reticulum stress.
Hu F, Li J, Zhang X, Fu Y, Mao Y, Tong S, Xu H
Acta diabetologica 2025 Nov;62(11):1859-1871
Acta diabetologica 2025 Nov;62(11):1859-1871
Exosomal gene signature in esophageal carcinoma: Insights from single-cell and bulk RNA sequencing.
Li H, Huang P, Wang Y, Zhang M, Gao D
Translational oncology 2025 Nov;61:102490
Translational oncology 2025 Nov;61:102490
Endoplasmic Reticulum Stress Is Involved in Prostaglandin F2α-Induced Goat Luteal Cell Apoptosis via the IRE1 Pathway.
Min X, Chen L, Wu Y, Zhang Y, Wang Y, Xiong X, Wen X
Reproduction in domestic animals = Zuchthygiene 2025 Nov;60(11):e70143
Reproduction in domestic animals = Zuchthygiene 2025 Nov;60(11):e70143
Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis.
Tang Y, Hu H, Chen S, Gong Y, Ge B
The Journal of international medical research 2025 Nov;53(11):3000605251396755
The Journal of international medical research 2025 Nov;53(11):3000605251396755
Caulerpin suppresses tumor-associated angiogenesis and tumor growth via Hippo signaling in cervical cancer.
Yang G, Mo Y, Rong H, Guo B, Zha Q, Shuai H, Wang M, Li P
Toxicology and applied pharmacology 2025 Nov;504:117541
Toxicology and applied pharmacology 2025 Nov;504:117541
Expression Patterns of Deubiquitinating Enzymes in Paclitaxel-Treated Lung Cancer Cells.
Kim HY, Choi HS, Baek KH
Cell biology international 2025 Nov;49(11):1507-1517
Cell biology international 2025 Nov;49(11):1507-1517
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Liu J, Zhang ZZ, Yu GR, Han X
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Zhang Q, Yang Z, Ou X, Zhang M, Ji R, Wu G
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Bone morphogenetic protein 1 as a macromolecular pan-cancer biomarker modulating the immune microenvironment and malignant phenotypes in glioblastoma.
Yu Z, Hu F, Nie C, Fang X, Shen Y, Shang R, Liu H, Zhou Q, Zhang H, Gao A, Liang H
International journal of biological macromolecules 2025 Nov;331(Pt 1):148136
International journal of biological macromolecules 2025 Nov;331(Pt 1):148136
Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia.
Wang P, Li M, Wang W, Sun W, Zhen W, Sun Q, Ning B, Su G, Wang X
Molecular medicine reports 2025 Nov;32(5)
Molecular medicine reports 2025 Nov;32(5)
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder.
Wang R, Wang M, Chen J, Sun M, Zhao P, Zheng X, Li D, Long C, Shen L, Wei G, Wu S
Biochemical pharmacology 2025 Nov;241:117177
Biochemical pharmacology 2025 Nov;241:117177
PPM1G promotes chemoresistance in triple negative breast cancer by enhancing YAP signaling.
Huang W, Chen X, Wu H, Zhang C, Zhong W, Li X, Ouyang Y, Chen X, Song L, Wang X, Hu K, Xiong Z
Pharmacological research 2025 Nov;221:107978
Pharmacological research 2025 Nov;221:107978
Chrysin inhibits PEDV replication by antagonizing apoptosis via the ROS/JNK/p53 axis.
Zhi Y, Ren Y, Xia X, Tian Q, Meng Y, Tao S
Microbial pathogenesis 2025 Nov;208:107957
Microbial pathogenesis 2025 Nov;208:107957
Protective Effect of Vinegar Powder on (60)Coγ Radiation-Injured Mice and Its Potential Mechanism.
Huang H, Shi Y, Liu X, Hao L, Zhu J, Lu J
The Journal of nutrition 2025 Nov;155(11):3663-3675
The Journal of nutrition 2025 Nov;155(11):3663-3675
DST-3, a novel cryptotanshinone derivate, attenuates glutamate excitotoxicity after ischemic stroke via CREB-Homer1 axis activation.
Dai Y, Yu J, He G, Liang M, Wen YZ, Guan R, Ye X, Guo Y, Lu J, Chen J, Liu P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157223
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157223
Calcitriol/Vitamin D receptor ameliorates fructose-induced enteritis-hepatitis axis dysregulation in mice.
Yu J, Zhu H, Yu X, Liu Y, Zhang J, Jiang L, Zhang X
The Journal of nutritional biochemistry 2025 Nov;145:110017
The Journal of nutritional biochemistry 2025 Nov;145:110017
SIRT3 deficiency aggravates mitochondrial metabolic disorder and podocyte injury in DKD via MPC2 acetylation.
Feng J, Feng L, Yan Y, Ye H, Tang K, Guo X, Ma Y
Cellular signalling 2025 Nov;135:112029
Cellular signalling 2025 Nov;135:112029
PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis.
Zhang Z, Yang Z, Ge H, Liu C, Fan R, Yuan C, You S, Hong C
Cellular signalling 2025 Nov;135:111999
Cellular signalling 2025 Nov;135:111999
Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke.
Gan H, Zhang M, Duan Y, Palahati A, He Q, Tan J, Li Y, Zhai X, Zhao J
Genes & diseases 2025 Nov;12(6):101614
Genes & diseases 2025 Nov;12(6):101614
Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia-Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling-Mediated Neutrophil Extracellular Traps Formation.
Tian H, Xiong Y, Zhan J, Lu Z, Zhang Y, Leng Y, Huang Q, Xia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09952
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09952
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.
Xie Y, Zhou Z, Song J, Wang C, Ding Y, Qiu Y, Fang L, Cheng H
Cancer science 2025 Nov;116(11):3196-3208
Cancer science 2025 Nov;116(11):3196-3208
Hypoglycemic effect and the post-treatment benefits of carrot pulp fermented by Lactobacillus casei NCU215 in type 2 diabetic mice: insights from gut microbiota regulation and restoration of pancreatic islet function.
Kang X, Xiong T, Yazhou X, Chen Y, Ruan Y, Guan Q
Journal of the science of food and agriculture 2025 Nov;105(14):7826-7839
Journal of the science of food and agriculture 2025 Nov;105(14):7826-7839
Dietary supplementation with selenium yeast mitigates diquat-induced oxidative damage in oviductal magnum of hens.
Yang J, Liu Y, Hu W, Wang Y, Chen R, Xu D, Liu L, Zheng L, Liu B, Fan Q, Zheng W, Yang X, Liu L
Poultry science 2025 Nov;104(11):105882
Poultry science 2025 Nov;104(11):105882
The impact of STAiR18 on multiple myeloma survival rates.
Wu Y, Wang H, Luo J, Lin J, Wu Y, Zheng S, Gao Y, Chen J, Che F, Shi J, Zhong L
Journal of translational medicine 2025 Nov 7;23(1):1243
Journal of translational medicine 2025 Nov 7;23(1):1243
Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis.
Duan J, Zhao N, Wang S, Li X, Li B, Cao G
Animals : an open access journal from MDPI 2025 Nov 3;15(21)
Animals : an open access journal from MDPI 2025 Nov 3;15(21)
Hydrogen Sulfide Attenuates Cisplatin-Induced Acute Kidney Injury via Dual Inhibition of Apoptosis and Pyroptosis.
Han Z, Jia Y, Yan D, Xue Y, Deng T, Wang P, Xiao L, Wang X
Biomedicines 2025 Nov 3;13(11)
Biomedicines 2025 Nov 3;13(11)
Neuroprotective effects of hyperbaric oxygen therapy on vascular cognitive impairment in hypoperfused mice via miR-137-3p/TRAF3 pathway.
Yang L, Zhu HZ, Xie L, Yang J, Wei HT, Yu QT, Li H, Yang M, Li Z
Translational psychiatry 2025 Nov 29;15(1):537
Translational psychiatry 2025 Nov 29;15(1):537
REDD1 Affects Proliferation, Apoptosis, Migration, and Colony Formation via p-ERK and p-JNK Signaling in Lung Adenocarcinoma Cells Under Hypoxia.
Fang X, Wang X, Liu X, He Y
Biomedicines 2025 Nov 28;13(12)
Biomedicines 2025 Nov 28;13(12)
H(2)S-Activated Theranostic Platform for Precise Photoablation of Colorectal Tumors with NIR-II Dual-Modal Phototherapy.
Wu K, Sun L, Wu H, Zheng X, Xue Y, Zhang Z, Ma S, Zhao C, Liu Y, Gu X
Journal of medicinal chemistry 2025 Nov 27;68(22):24684-24700
Journal of medicinal chemistry 2025 Nov 27;68(22):24684-24700
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Tang Z, Guo C, Wen N, Jin H, Dong Y, Xu B, Ma X, Han L, Liu J
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway.
Yang Q, Shi Y, Li W, Xiong X, Chen Q, Zheng M
Biology direct 2025 Nov 27;20(1):113
Biology direct 2025 Nov 27;20(1):113
Panax notoginseng saponins suppress the PI3K/AKT pathway to enhance autophagy and apoptosis in pulmonary fibrosis.
Hou J, Li L, Sun CB, Li TG, Zhang SQ, Liang PT, Jin YL, Yuan JL, Li L, Yan JY, Fu Y, Yang ZS
Scientific reports 2025 Nov 27;15(1):43622
Scientific reports 2025 Nov 27;15(1):43622
ADRA2A contributes to airway inflammation and apoptosis in asthma through the ERK signaling in vitro and in vivo.
Zhou F, Cai J, Chen L, Tan X, Li C
Journal of inflammation (London, England) 2025 Nov 26;22(1):55
Journal of inflammation (London, England) 2025 Nov 26;22(1):55
Exercise-derived peptide confers protection against septic cardiomyopathy by enhancing CCAAT/enhancer binding protein β-mediated autophagy.
Huang X, Xu K, Wang Y, Xiao Q, Ci H, Fu X, Li Y, Zhuang F, Cai Z, Zhou G, Huo H, He B, Wang X, Shen L
Cellular and molecular life sciences : CMLS 2025 Nov 25;82(1):421
Cellular and molecular life sciences : CMLS 2025 Nov 25;82(1):421
Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites.
Qi X, Deng M, Li M, Ma W, Zhou Y
Metabolic brain disease 2025 Nov 25;40(8):325
Metabolic brain disease 2025 Nov 25;40(8):325
Saponins from Dioscorea nipponinca Makino rehabilitate UVB-induced skin photoaging by inhibiting oxidative stress and apoptosis via targeting STAT3.
Cai Q, Zhang Q, Zhang Y, Xue X, Han L, Peng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157452
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157452
Jianpi Huayu decoction exerts antitumor effects in pancreatic cancer via SCD1-mediated lipid metabolism remodeling/ferroptosis axis.
Chen X, Ren Y, Yao R, Liu S, Fang C, Luo R, Shi H, Zhu X, Lai Y, Zhao X, Zhong C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157389
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157389
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Glycyrrhetinic acid orchestrates ERS-pyroptosis crosstalk to elicit immunogenic cell death in hepatocellular carcinoma.
Bian M, Ji J, Lian N, Li Y, Zhu W, Cao P, Zhang F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157309
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157309
Gastrodin Injection Relieves Hypoxic-Ischemic Brain Injury in Newborn Rats by Regulating the P62/Nrf2/HO-1 Pathway.
Wu S, Ren Z, Yang M, Xiong Y, Li X, Wu X, Xu J, Chen M
Molecular neurobiology 2025 Nov 24;63(1):150
Molecular neurobiology 2025 Nov 24;63(1):150
hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability.
Ji K, Zhou L, Zhang T, Fan H, Xie G, Man W, Wang C, Tian Y, Chen L, Wang G, Liu M, Zhu B, Zhang W, Yu G
Cell death discovery 2025 Nov 24;11(1):542
Cell death discovery 2025 Nov 24;11(1):542
Trofinetide Improves Cognitive Function in APP/PS1 Mice by Suppressing Inflammation and Apoptosis.
Chen M, Ning Y, Yang H, Jia J
Molecular neurobiology 2025 Nov 21;63(1):129
Molecular neurobiology 2025 Nov 21;63(1):129
Human OPN-derived peptide SV prevents BPD model through interacting with KIF5B to repair mitochondrial damage and inhibit apoptosis.
Yan R, Zhang H, Zhang P, Lv M, Pu Y, Yu L, Jin W, Zhang L, Zhou Y
iScience 2025 Nov 21;28(11):113691
iScience 2025 Nov 21;28(11):113691
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Zheng Y, Fu Z, Yang S, Ma Q, Liu X, Wang Y, Geng T, Hao J, Li X
Medicine 2025 Nov 21;104(47):e46122
Medicine 2025 Nov 21;104(47):e46122
Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer.
Feng Y, Zhou S, Yang B, Yang J, Wang S, Yu Z, Quan C, Chen J
Discover oncology 2025 Nov 19;16(1):2134
Discover oncology 2025 Nov 19;16(1):2134
Integrated analysis of Corylin from Psoralea Corylifolia inhibiting osteoporosis via MAPK pathway.
Liu N, Yang Z, Yanzhang R, Shen R, Yi W, Teng J
Scientific reports 2025 Nov 19;15(1):40724
Scientific reports 2025 Nov 19;15(1):40724
Silibinin mitigates AKI-to-CKD transition via MAPK and PI3K/AKT signaling pathways in Ischemia-Reperfusion injury.
Dong S, Jian J, Xiong Y, Wang J, Lu Q, Li W, Wan S, Wang L
Scientific reports 2025 Nov 18;15(1):40609
Scientific reports 2025 Nov 18;15(1):40609
Influenza a(H1N1) virus infection impairs syncytiotrophoblast functions by promoting ferroptosis through the TNF-α/ISG15/EGR1 axis.
Zhao Y, Wang Y, Huang K, Wang F, Wang Y
Virology journal 2025 Nov 17;22(1):379
Virology journal 2025 Nov 17;22(1):379
TIM3 attenuates morphine antinociceptive tolerance and microglial neuroinflammation by suppressing the TRAF6/NF-κB pathway in male mice.
Yang H, Shen T, Qi Z, Yang Z, Zhang M, Jiang J, Sun Z, Lu C
Neuropharmacology 2025 Nov 15;279:110638
Neuropharmacology 2025 Nov 15;279:110638
Monotropein alleviates sepsis-associated encephalopathy by targeting matrix metalloproteinase-9.
Xin Y, Guan T, Wang G, Xiang Y, Li M, Zhao Y, Zhao P
Neuropharmacology 2025 Nov 15;279:110636
Neuropharmacology 2025 Nov 15;279:110636
CDC5L facilitates cardiomyocyte proliferation and ameliorates myocardial ischemia-reperfusion injury via modulation of the FGF10-YAP axis.
Wei T, Wan T, Sun Y, Liang Y, Lin Z, Shen S, Zhang Q, Chen M, Li Y
Acta biochimica et biophysica Sinica 2025 Nov 14;57(12):2110-23
Acta biochimica et biophysica Sinica 2025 Nov 14;57(12):2110-23
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
Tulahong A, Xu X, Zhou T, Ruze R, Yuan Z, Qiao P, Jiang T, Aji T, Shao Y
International immunopharmacology 2025 Nov 14;165:115508
International immunopharmacology 2025 Nov 14;165:115508
CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis.
Li Y, Li H, Chen X, Li X, Su J, Yang S, Xiao W, Deng Z
Cellular & molecular biology letters 2025 Nov 13;30(1):135
Cellular & molecular biology letters 2025 Nov 13;30(1):135
Single-atom Ca nanozyme induces glioma death through Ca(2+)-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment.
Jin Z, Li X, Hou X, Hu J, Zhuo Y, Shi J, Xu T, Zhao Q, Jing Z
Journal of nanobiotechnology 2025 Nov 13;23(1):716
Journal of nanobiotechnology 2025 Nov 13;23(1):716
Mechanism of the traditional Chinese medicine SMBJ alleviates diabetes mellitus-induced Leydig cell dysfunction in rats testes.
Zhang W, Liu Y, Tong L, Jin Y, Gao C, Cui Y, Jin B, Sun D
Scientific reports 2025 Nov 12;15(1):39656
Scientific reports 2025 Nov 12;15(1):39656
GABA treatment promoting cell apoptosis in meningioma correlates with EGFR/BCL-2/BAX axis.
Yang X, Wang L, Wu H, Li C, Zhang L
Journal of neuro-oncology 2025 Nov 11;176(1):78
Journal of neuro-oncology 2025 Nov 11;176(1):78
Optimization strategies for reversible myocardial injury caused by ultrasonic cavitation effects using an orthogonal experimental design.
Zhao L, Li X, Huang D, Zhao Y, Cao H, Liao C, Yuan Y, Xi X, Li S, Zhang B
Scientific reports 2025 Nov 11;15(1):39471
Scientific reports 2025 Nov 11;15(1):39471
Targeting the p38/MAPK pathway to induce apoptosis: a multidimensional mechanistic exploration of Mentha and its active compound diosmetin against liver cancer.
Song Y, Du Y, Li W, Fan Y, Zhang Y, Shen H, Cheng L, Wang J, Deng F, Tang B
Scientific reports 2025 Nov 11;15(1):39432
Scientific reports 2025 Nov 11;15(1):39432
WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.
Zhang Y, Li N, Zhang D, Zhang H
Human cell 2025 Nov 10;39(1):3
Human cell 2025 Nov 10;39(1):3
Wuling San ameliorates cerebral ischemia-reperfusion injury via suppression of the TRPM2/NLRP3 pathway.
Li H, Tao D, Chen Y, Deng Y, Wei W, Xue X
European journal of medical research 2025 Nov 10;30(1):1096
European journal of medical research 2025 Nov 10;30(1):1096
Precision hyperthermia-induced HSP20 inhibits gastric cancer cell invasion, migration, and proliferation.
Sun Q, Long Z, Wang Y, Ren J, Wang D
Discover oncology 2025 Nov 10;16(1):2070
Discover oncology 2025 Nov 10;16(1):2070
Targeting cuproptosis by FDX1 in acetaminophen-induced liver injury.
Liu Y, Yang Y, Peng B, Ou Z, Zuo A, Jiang Z, Wu C, Kwan HY, Ma K, Yu L, Zhao X
Chemico-biological interactions 2025 Nov 1;421:111753
Chemico-biological interactions 2025 Nov 1;421:111753
Phytosphingosine suppresses gastric cancer through SFRP4/β-catenin axis-mediated Wnt signaling pathway inhibition.
Liu Y, Guo R, Xue C, Zhang X, Xiao F, Zhao X, Zhu Z, Li K
Chemico-biological interactions 2025 Nov 1;421:111749
Chemico-biological interactions 2025 Nov 1;421:111749
Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.
Zhu Z, Shi L, Li H, Wang X, Gao J, Cheng L, Zhang X
Briefings in bioinformatics 2025 Nov 1;26(6)
Briefings in bioinformatics 2025 Nov 1;26(6)
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Li ZD, Kang S, Li H, Yu P, Xie R, Li C, Jing Q, Gong Z, Li L, Li Z, Geng M, Zhang Z, Li Y, Chang YZ
Redox biology 2025 May;82:103611
Redox biology 2025 May;82:103611
Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study.
Zhang J, Guo J, Qian Y, Yu L, Ma J, Gu B, Tang W, Li Y, Li H, Wu W
Cancer reports (Hoboken, N.J.) 2025 May;8(5):e70220
Cancer reports (Hoboken, N.J.) 2025 May;8(5):e70220
The antitumor effects and apoptotic mechanism of 20(S)-Protopanaxadiol in acute myeloid leukemia.
Zhang Y, Ma S, Xu Y, Wu S, Wu S, Liu M, Guo Y, Zhan Y
Journal of ginseng research 2025 May;49(3):306-314
Journal of ginseng research 2025 May;49(3):306-314
eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53.
Li DY, Hu XX, Tian ZR, Ning QW, Liu JQ, Yue Y, Yuan W, Meng B, Li JL, Zhang Y, Pan ZW, Zhuang YT, Lu YJ
Acta pharmacologica Sinica 2025 May;46(5):1236-1249
Acta pharmacologica Sinica 2025 May;46(5):1236-1249
Daidzein Attenuates Cadmium-Induced Neurotoxicity via Inhibiting Apoptosis and Mitophagy in the Cerebral Cortex of Sprague-Dawley Rats.
Wen S, Zhao Y, Wang L, Yuan Y
Journal of biochemical and molecular toxicology 2025 May;39(5):e70299
Journal of biochemical and molecular toxicology 2025 May;39(5):e70299
Menstrual Blood-Derived Endometrial Stem Cells Ameliorate Ovarian Senescence by Relieving Oxidative Stress-Induced Inflammation.
Song H, Zhang R, Liu Y, Wu J, Fan W, Wu J, Liu Y, Lin J
Reproductive sciences (Thousand Oaks, Calif.) 2025 May;32(5):1566-1579
Reproductive sciences (Thousand Oaks, Calif.) 2025 May;32(5):1566-1579
Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure.
Tong L, Wang Q, Zhang Y, Lai F, Xu J, Yin W, Zhang S, Wei G, Yin J, Yi H, Storm G, Wang Z, Huang R, Xu T, Wang JW
Biomaterials 2025 May;316:122976
Biomaterials 2025 May;316:122976
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549
International journal of biological macromolecules 2025 May;310(Pt 4):143549
Host genetic variation governs PCV2 susceptibility through CXCL13 and ELK1-mediated immune regulation.
Liu G, Gao Y, Cheng Y, Wang W, Li X, Wu Y, Gao F, Zhou ZW, Sun Y, Jiang Y, Yang N, Shu Y, Sun L
International journal of biological macromolecules 2025 May;310(Pt 3):143170
International journal of biological macromolecules 2025 May;310(Pt 3):143170
Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy.
Li Y, Wang Y, Yao H, Li Z, Wang L, Song S, Li J, Li Y, Yang M, Zhang K, Han Y, Zhao Y, Yao S, Li Q, Ma Z, Xu D, Zhao Z
International journal of biological macromolecules 2025 May;310(Pt 2):143119
International journal of biological macromolecules 2025 May;310(Pt 2):143119
Investigating the molecular mechanism of purslane‑based vitiligo treatment using network pharmacology, molecular docking and in vitro analyses.
Zhang X, Meng L, Ran X, Li S, Wen C
Molecular medicine reports 2025 May;31(5)
Molecular medicine reports 2025 May;31(5)
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer.
Yang C, Ma H, Liang Z, Zhuang Y, Hu L, Zhang K, Huang L, Li M, Zhang S, Zhen Y
International journal of biological macromolecules 2025 May;308(Pt 1):142272
International journal of biological macromolecules 2025 May;308(Pt 1):142272
Targeting mRNA export complex macromolecules THO subunits (Thoc2 and Thoc5) for somatic cell reprograming.
Rehman A, Wang H, Li C, Fatima I, Noor F, Ding Y, He Z, Dong H, Ni Y, Meng Y, Qasim M, Shi X, Liao M
International journal of biological macromolecules 2025 May;307(Pt 3):142072
International journal of biological macromolecules 2025 May;307(Pt 3):142072
A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep.
Cai Y, Xu H, Deng K, Yang H, Zhao B, Zhang C, Li S, Wei Z, Wang Z, Wang F, Zhang Y
International journal of biological macromolecules 2025 May;306(Pt 1):141271
International journal of biological macromolecules 2025 May;306(Pt 1):141271
HKDC1 promotes colorectal cancer progression by regulating RCOR1 expression to activate the Wnt/β-catenin pathway, enhancing proliferation, migration, and epithelial-mesenchymal transition.
Huang S, Pang Q, Zhang Y, Cao J
The Journal of biological chemistry 2025 May;301(5):108478
The Journal of biological chemistry 2025 May;301(5):108478
PDZK1 regulated by miR-145-5p protects against endothelial cell apoptosis and diabetic retinopathy by targeting mitochondrial function.
An M, Huang J, Zhao J, Wang L, Liu Y
Experimental eye research 2025 May;254:110314
Experimental eye research 2025 May;254:110314
Five racemic phthalides from the aerial parts of Lycopodiastrum casuarinoides and their neuroprotective activities.
Liu Y, Chen X, Liu XJ, Liu R, Hu HL, Min SX, Huang CH, Liu L, Tan GS
Phytochemistry 2025 May;233:114384
Phytochemistry 2025 May;233:114384
Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway.
Wang S, Yang Y, Lin J, Zhang W, Yang C, Zhang R, Zhou C, Zhang L, Wang X, Liu J, Jin X, Ma Y
Free radical biology & medicine 2025 May;232:72-85
Free radical biology & medicine 2025 May;232:72-85
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
Zhao Z, Wang R, Ge H, Hou L, Hatano T, Hattori N, Su H, Wang Q, Zhao J
Free radical biology & medicine 2025 May;232:56-71
Free radical biology & medicine 2025 May;232:56-71
EPIC-1042 alleviates cerebral ischemic/reperfusion injury through TAX1BP1-induced mitophagy.
Ju J, Cheng C, Cui L, Hong B, Zhan Q, Wang Q, Cui X, Su D, Huang Y, Kang C
Free radical biology & medicine 2025 May;232:367-381
Free radical biology & medicine 2025 May;232:367-381
Formosanin C inhibits triple-negative breast cancer progression by suppressing the phosphorylation of STAT3 and the polarization of M2 macrophages.
Dai YW, Wu ZX, Cheng Y, Wu HD, Chen JW, Lv LX, Wang ZQ, Li HF, Yan CZ, Bao JX, Liu CH, Dai XX
Breast cancer research and treatment 2025 May;211(1):71-89
Breast cancer research and treatment 2025 May;211(1):71-89
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice.
Huang Z, Pan Y, Ma K, Luo H, Zong Q, Wu Z, Zhu Z, Guan Y
Applied biochemistry and biotechnology 2025 May;197(5):3026-3047
Applied biochemistry and biotechnology 2025 May;197(5):3026-3047
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Ou Y, Zhang K, Shuai Q, Wang C, Hu H, Cao L, Qi C, Guo M, Li Z, Shi J, Liu Y, Zuo S, Chen X, Wang Y, Feng M, Wang H, Sun P, Shi Y, Yang G, Yang S
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome.
Xin W, Yang H, Heng X, Xu T, Zhang K, Zhao Y, Liu Y, Han D, Wu Y, Zhang W, He M, Pu L, Shen Y, Qu X, Sun N, Ye C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156624
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156624
Mg(2+)-Loaded Black Phosphorus Nanosheet Protects against Cerebral Ischemic Injury through Anti-Oxidative and Anti-Inflammatory Effects.
Wang M, Xia X, Li Y, Zhang K, Cheng X, Wen X, Zhao L, Guo X, Song F, Cheng A
Advanced healthcare materials 2025 May;14(13):e2500929
Advanced healthcare materials 2025 May;14(13):e2500929
Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway.
Li C, Luo H, Chen M, Lin F, Ren X, Huang Y, Zhou L
Reproductive toxicology (Elmsford, N.Y.) 2025 May;134:108882
Reproductive toxicology (Elmsford, N.Y.) 2025 May;134:108882
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Xi H, Shan W, Li M, Wang Z, Li Y
Andrology 2025 May;13(4):911-920
Andrology 2025 May;13(4):911-920
Study on the effects and mechanism of RRM2 on three gynecological malignancies.
Yang L, Zhang H, Wang J, Ge J, Hao R, Yu J, Zheng B
Cellular signalling 2025 May;129:111674
Cellular signalling 2025 May;129:111674
LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese.
Xiao X, Liu H, Yao R, Li Y, Liao X, Liu Y, Zhou Y, Wang J, Tang B, Jiao B, Li J, Shen L, Luo S
The journal of prevention of Alzheimer's disease 2025 May;12(5):100087
The journal of prevention of Alzheimer's disease 2025 May;12(5):100087
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
He D, Chen S, Wang X, Wen X, Gong C, Liu L, He G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2412953
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2412953
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway.
Ma CS, Han B, Meng SC, Bai M, Yi WJ, Zhang LY, Duan MY, Wang YJ, He MT
International immunopharmacology 2025 May 8;154:114518
International immunopharmacology 2025 May 8;154:114518
Rilmenidine attenuates intracerebral hemorrhage by regulating autophagy flux and apoptosis via the HO-1/Fe(2+)/ERK pathway.
Hua Q, Lu M, Li Z, Song P, Gao L, Zhou L, Zhang J, Cai Q
Neuroscience 2025 May 7;573:382-398
Neuroscience 2025 May 7;573:382-398
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
Sun C, Du Z, Yang W, Wang Q
Discover oncology 2025 May 30;16(1):952
Discover oncology 2025 May 30;16(1):952
Effect of periplocin on malignant behavior of oral squamous cell carcinoma cells.
Zhao Q, Lu Y, Lu H, Wang D, Shang H, Yao M, Liu T
Translational cancer research 2025 May 30;14(5):2722-2736
Translational cancer research 2025 May 30;14(5):2722-2736
GPR35 prevents drug-induced liver injury via the Gαs-cAMP-PKA axis in macrophages.
Zhao X, Li Y, Yang L, Chen X, Zhang J, Chen T, Wang H, Li F, Cheng C, Wu J, Cong J, Yin W, Li J, Wang X
Cellular and molecular life sciences : CMLS 2025 May 29;82(1):219
Cellular and molecular life sciences : CMLS 2025 May 29;82(1):219
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Xu H, Cai Y, Yang H, Zhang C, Liu W, Zhao B, Wang F, Zhang Y
Communications biology 2025 May 29;8(1):824
Communications biology 2025 May 29;8(1):824
Mechanistic Insights into T-2 Toxin-Induced Thymic Epithelial Cell Injury and Immunotoxicity via the ROS-NF-κB-NLRP3 Signaling Axis.
Zhang Y, Chen M, Niu R, Guo D, Sun Z
Journal of agricultural and food chemistry 2025 May 28;73(21):12961-12977
Journal of agricultural and food chemistry 2025 May 28;73(21):12961-12977
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Chu Z, Chen Y, Xie D, Song C, Yang L, Qin T, Zhai Z, Cao Z, Xu Y, Sun T
Journal of ethnopharmacology 2025 May 28;348:119879
Journal of ethnopharmacology 2025 May 28;348:119879
Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
Zhang X, Wang L, Huang L, Cao G, Huang C, Duan Y, Lyu W
Journal of ethnopharmacology 2025 May 28;348:119793
Journal of ethnopharmacology 2025 May 28;348:119793
Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.
Yang K, Zhang X, Yang K, Liu S, Zhang J, Fu Y, Liu T, Wu K, Li J, Liu C, Huang Q, Qu K
Molecular medicine (Cambridge, Mass.) 2025 May 27;31(1):209
Molecular medicine (Cambridge, Mass.) 2025 May 27;31(1):209
Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer.
Dong Z, Chang X, Luo X, Li H, Deng M, Huang Z, Chen T, Chen Y, Sun B, Wu Y, Wu R, Wu Q, Zhu J, Zheng J
Scientific reports 2025 May 24;15(1):18115
Scientific reports 2025 May 24;15(1):18115
miRNA-1229-5p promotes migration and invasion and suppresses apoptosis of endometrial cells via the STMN1/p38 MAPK axis in endometriosis.
Liu L, Wang L, Hao N, Du N, Li Y, Kang S
Gene 2025 May 20;950:149385
Gene 2025 May 20;950:149385
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
Li C, Liu S, Gao J, Xu Y, Peng Q, Weng D, Wang D, Yang W, Yi P, Lin Z, Chen J
Gene 2025 May 20;950:149369
Gene 2025 May 20;950:149369
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.
Zhang Q, Ma S, Kang X, Liu Y, Ma F, Yu F, Luo X, Li G, Hao Y, Zhang H, Liu B, Jiang Y
Journal of nanobiotechnology 2025 May 20;23(1):365
Journal of nanobiotechnology 2025 May 20;23(1):365
Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.
Lin Y, Zhang Y, Huang T, Chen J, Li G, Zhang B, Xu L, Wang K, He H, Chen H, Liu D, Guo S, He X, Lan P
Cancer research 2025 May 2;85(9):1663-1679
Cancer research 2025 May 2;85(9):1663-1679
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.
Wang Z, Yu C, Xie G, Tao K, Yin Z, Lv Q
Molecular medicine (Cambridge, Mass.) 2025 May 2;31(1):163
Molecular medicine (Cambridge, Mass.) 2025 May 2;31(1):163
Inflammation-responsive biomimetic nanoparticles with epigallocatechin-3-gallate for acute lung injury therapy via autophagy enhancement.
Han Y, Liu T, Wei R, Dai C, Huang X, Hu D
iScience 2025 May 16;28(5):112318
iScience 2025 May 16;28(5):112318
Polysaccharides from Dicliptera chinensis (L.) Juss. Attenuates drug-induced liver injury by phosphorylating AMPK and thus facilitating the entry of FOXO3 into the cell nucleus.
Yang C, Zhong M, Jiao X, Cao H, Qin Y, Xu H, Guo F, Tang Z, Lv T, Guan L, Wang Y, Gao Y, Zhang K
International immunopharmacology 2025 May 16;155:114633
International immunopharmacology 2025 May 16;155:114633
Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-κB and MAPK pathways.
Wu Z, Wang J, Chen K, Yu Q, Zhou X, Wu L, Sun C
International immunopharmacology 2025 May 16;155:114630
International immunopharmacology 2025 May 16;155:114630
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Ning Q, Liu J, Liu S, Zou Q, Li K, Li Z
International immunopharmacology 2025 May 16;155:114610
International immunopharmacology 2025 May 16;155:114610
Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-κB.
Liu Y, Zhao W, Lv X, Wu G, Zhou X, Tian H, Qv X, Sun H, He Y, Zhang Y, Wang C, Tian J
International immunopharmacology 2025 May 16;155:114588
International immunopharmacology 2025 May 16;155:114588
Long noncoding RNA SNHG5 promotes 5-fluorouracil resistance in colorectal cancer by regulating miR-26b/p-glycoprotein axis.
Wang B, Zhou Q, Cheng CE, Gu YJ, Jiang TW, Qiu JM, Wei GN, Feng YD, Ren LH, Shi RH
World journal of gastrointestinal oncology 2025 May 15;17(5):102417
World journal of gastrointestinal oncology 2025 May 15;17(5):102417
Corynoxeine Supplementation Ameliorates Colistin-Induced Kidney Oxidative Stress and Inflammation in Mice.
Liu Y, Zhang R, Velkov T, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2025 May 15;14(5)
Antioxidants (Basel, Switzerland) 2025 May 15;14(5)
Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages.
Jin Z, Wei Y, Zhou Z, Fan Z, Huang Y, Liu D
Journal of agricultural and food chemistry 2025 May 14;73(19):11730-11755
Journal of agricultural and food chemistry 2025 May 14;73(19):11730-11755
Phytochemical characterization and pharmacological mechanisms of Huazhuo Sanjie Chubi Decoction in treating gouty arthritis: A multivariant approach.
Chen X, Zhong X, Guo J, Jin T, Guan H, Lin J, Zeng M, Zhang Y, Lin Y, Chang D, Zheng Y, Zhou X, Huang M, Su Y
Journal of ethnopharmacology 2025 May 12;347:119731
Journal of ethnopharmacology 2025 May 12;347:119731
Integrating metabolomics and network pharmacology to investigate Mu Jin Powder prevents ethanol-induced gastric ulcer in rats.
Shi JX, Huo JN, Luo X, Zhang Q, Han LY, Wu X, Bao YR, Wang S, Li TJ, Dong BQ, Meng XS
Journal of ethnopharmacology 2025 May 12;347:119730
Journal of ethnopharmacology 2025 May 12;347:119730
Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia.
Feng X, Qin Y, Feng Y, Zhuo Y
Discover oncology 2025 May 12;16(1):739
Discover oncology 2025 May 12;16(1):739
Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species.
Yousuf W, Siddiqui NZ, Ali P, Cheng S, Ansari I, Song J, Dai M, Qiu Z, Zhu Y, Zhang Y, Liu S, Zhang Y, Liu Z, Liu H
Cells 2025 May 12;14(10)
Cells 2025 May 12;14(10)
Liraglutide Inhibits Autophagy to Ameliorate Post-Cardiac Arrest Brain Injury and Ferroptosis in Rats.
Xing C, Fan X, Liu M, Chen Y, Jia J, Li W, Yu H, Zhou J
Neurochemical research 2025 May 11;50(3):161
Neurochemical research 2025 May 11;50(3):161
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.
Ding J, Zhang S, Li Q, Xia B, Wu J, Lu X, Huang C, Yuan X, You Q
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 May 1;29(3):307-319
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 May 1;29(3):307-319
Inhibition of microRNA-139-5p by glucagon-like peptide-1 ameliorates oxidative stress-induced vascular endothelial cell damage via targeting SOD1/GCLc.
Zhang J, Mo J, Liu Y, Meng X, Tang W, Fu L, Xiong J, Mo Z
Endocrine connections 2025 May 1;14(5)
Endocrine connections 2025 May 1;14(5)
Protective role of vitamin D receptor against mitochondrial calcium overload from PM(2.5)-Induced injury in renal tubular cells.
Lu M, Zhan Z, Li D, Chen H, Li A, Hu J, Huang Z, Yi B
Redox biology 2025 Mar;80:103518
Redox biology 2025 Mar;80:103518
DANCR knockdown alleviates neuroinflammation and functional recovery after spinal cord injury via regulating the ACTN4 / STAT3 axis.
Xia B, Yu C, Liu J, Lin J, Lyu J, Wang X, Zhu L
Archives of biochemistry and biophysics 2025 Mar;765:110293
Archives of biochemistry and biophysics 2025 Mar;765:110293
TUBB4A Inhibits Glioma Development by Regulating ROS-PINK1/Parkin-Mitophagy Pathway.
Xi X, Chen S, Zhao X, Zhou Z, Zhu S, Ren X, Wang X, Wu J, Mu S, Li X, Shan E, Cui Y
Molecular neurobiology 2025 Mar;62(3):3125-3142
Molecular neurobiology 2025 Mar;62(3):3125-3142
17β-Trenbolone Exposure Enhances Muscle Activity and Exacerbates Parkinson's Disease Progression in Male Mice.
Zuo X, Bai HJ, Zhao QL, Zhang SH, Zhao X, Feng XZ
Molecular neurobiology 2025 Mar;62(3):3053-3066
Molecular neurobiology 2025 Mar;62(3):3053-3066
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells.
Wang Q, Zhang C, Yu B, Zhang Y, Guo Y
Free radical research 2025 Mar;59(3):250-261
Free radical research 2025 Mar;59(3):250-261
Terazosin, a repurposed GPR119 agonist, ameliorates mitophagy and β-cell function in NAFPD by inhibiting MST1-Foxo3a signalling pathway.
Zhang C, Li J, Wang L, Ma J, Li X, Wu Y, Ren Y, Yang Y, Song H, Li J, Yang Y
Cell proliferation 2025 Mar;58(3):e13764
Cell proliferation 2025 Mar;58(3):e13764
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop.
Yu ST, Sun ZY, Li N, Qu ZZ, Wang CH, Ju TT, Liu YQ, Mei ZT, Liu KW, Lu MX, Huang M, Li Y, Dou SK, Jiang JH, Zhang YZ, Huang CH, Pang XC, Jia YQ, Dong XH, Wu F, Zhang Y, Li WH, Yang BF, Du WJ
Acta pharmacologica Sinica 2025 Mar;46(3):592-605
Acta pharmacologica Sinica 2025 Mar;46(3):592-605
Berberine Inhibits Migration and Apoptosis of Rat Podocytes in Diabetic Nephropathy via the Novel lncRNA LOC102549726 Related Pathway.
Wang C, Wu H, Xie Y, Wang J, Huang L, Ni X, Deng S, Zhang Y, Chen X, Zhang H, Yuan S, Tang L
Phytotherapy research : PTR 2025 Mar;39(3):1615-1631
Phytotherapy research : PTR 2025 Mar;39(3):1615-1631
Pubescenoside D Ameliorates Myocardial Ischemia-Reperfusion Injury via Preventing the Dissociation of HK2 and Promoting Mitophagy by Targeting GSK-3β.
Xiao J, Wu P, Wang L, Luo J, Wang Y, Cheng Y, Zhang R, Liu Z
Phytotherapy research : PTR 2025 Mar;39(3):1578-1591
Phytotherapy research : PTR 2025 Mar;39(3):1578-1591
Mangiferin Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the GAS6/Axl Signaling Pathway.
Zhao A, Lei W, Tian J, Wu X, Li M, Zhang Y, Wu X, Xu X, Tang J, Yang Y, Jin Z
Phytotherapy research : PTR 2025 Mar;39(3):1388-1402
Phytotherapy research : PTR 2025 Mar;39(3):1388-1402
Oleanolic acid improves the in vitro developmental competence of early porcine embryos by reducing oxidative stress and ameliorating mitochondrial function.
Dong YW, Qu HX, Wang YQ, Qi JJ, Wei HK, Sun BX, Sun H, Liang S
Animal bioscience 2025 Mar;38(3):431-443
Animal bioscience 2025 Mar;38(3):431-443
Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2.
Zhang XN, Li YY, Lyu SC, Jia QJ, Zhang JP, Liu LT
Chinese journal of integrative medicine 2025 Mar;31(3):240-250
Chinese journal of integrative medicine 2025 Mar;31(3):240-250
NGR1 reduces neuronal apoptosis through regulation of ITGA11 following subarachnoid hemorrhage.
Hou Y, Zhang L, Ma W, Jiang Y
Molecular medicine reports 2025 Mar;31(3)
Molecular medicine reports 2025 Mar;31(3)
Mild hypothermia (35°C) reduces myocardial ischemia-reperfusion injury and attenuates hypoxia induced apoptosis of H9C2 cardiomyocytes by changing the phosphorylation level of Connexin43 (Cx43) protein.
Lu Y, Wang F, Xiao N, Fan Z, Xiong L, Kou J, Wang T, Li D
African health sciences 2025 Mar;25(1):205-229
African health sciences 2025 Mar;25(1):205-229
MicroRNA-9-5p regulates apoptosis of human osteoarthritis chondrocytes through suppressing TnC.
Yi X, Lei J, Hua Y, Chen C, Yang J
African health sciences 2025 Mar;25(1):179-192
African health sciences 2025 Mar;25(1):179-192
Selenium triggers AMPK-mTOR pathway to modulate autophagy related to oxidative stress of sheep Leydig cells.
Ma L, Li K, Guo Y, Liu J, Dong J, Li J, Ren Y, Shi L
Reproductive biology 2025 Mar;25(1):100973
Reproductive biology 2025 Mar;25(1):100973
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
DEF6 regulates renal ischemia reperfusion injury through suppressing the WWP2 mediated ubiquitination of PARP1.
Hu H, Liu Y, Han S, Guo J, Zhou J, Qiu T
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167681
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167681
Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.
Feng X, Ma Y, Zhao Y, Zhao Z, Song Z, Lin L, Wang W
Molecular immunology 2025 Mar;179:94-105
Molecular immunology 2025 Mar;179:94-105
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Lian X, Guo Z, Liu J, Zeng W
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
A Preliminary Study of Effect of Melatonin on Inflammation and Hypoxia-Related Factors in a Mouse Model of Elastase-Induced Intracranial Aneurysm.
NarenYa, Feng Y, Su Y, Chen L, Liu Y, Sun Z, Ma Z
Brain and behavior 2025 Mar;15(3):e70371
Brain and behavior 2025 Mar;15(3):e70371
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism.
Wu X, Wu X, Wang Z, Tian X, Zhang C, Cao G, Gu Y, Yan T
Drug delivery and translational research 2025 Mar;15(3):925-938
Drug delivery and translational research 2025 Mar;15(3):925-938
Trojan Horse-Like Biohybrid Nanozyme for Ameliorating Liver Ischemia-Reperfusion Injury.
Zheng DF, Zha XJ, Jiang EL, Qiu Y, Yang W, Xiao WD
Advanced healthcare materials 2025 Mar;14(7):e2404458
Advanced healthcare materials 2025 Mar;14(7):e2404458
Allium Macrostemon Bge. Attenuates the Cognitive Decline of Aging Mice by Enhancing BDNF/TrkB Pathway.
Sheng R, Zhao M, Pu K, Zhou Y, Zeng L, Chen Y, Wang P, Liu X, Xu S
Food science & nutrition 2025 Mar;13(3):e70010
Food science & nutrition 2025 Mar;13(3):e70010
SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.
Liu W, Ni Y, Wang W, Cui K, Duan Q, Bai Z, Shahzad A, Liu X, Dong Y, Xu Z, Zhang J, Peng D, Teng Z, Gao Y, Yang Z, Zhang Q
Cellular signalling 2025 Mar;127:111591
Cellular signalling 2025 Mar;127:111591
Pelvic vasectomy and its protective effects on rat testis function.
Yang H, Chen Y, Cheng X, Wu J, Huang R, Qian B, Wang G
Basic and clinical andrology 2025 Mar 7;35(1):9
Basic and clinical andrology 2025 Mar 7;35(1):9
AKR1C3 protects cardiomyocytes against hypoxia-induced cell apoptosis through the Nrf-2/NF-κB pathway.
Zhang W, Tian W, Xia X, Tian H, Sun T
Acta biochimica et biophysica Sinica 2025 Mar 6;57(7):1151-1163
Acta biochimica et biophysica Sinica 2025 Mar 6;57(7):1151-1163
Clemastine fumarate alleviates endoplasmic reticulum stress through the Nur77/GFPT2/CHOP pathway after ischemia/reperfusion in rat hearts.
He Y, Sun F, Song C, Liu Y, Wang R, Wang Y, Sun X, Juan Z, Wang Y
International immunopharmacology 2025 Mar 6;149:114242
International immunopharmacology 2025 Mar 6;149:114242
Cornuside as a promising therapeutic agent for diabetic kidney disease: Targeting regulation of Ca(2+) disorder-mediated renal tubular epithelial cells apoptosis.
Gao G, Su X, Liu S, Wang P, Chen JJ, Liu T, Xu J, Zhang Z, Zhang X, Xie Z
International immunopharmacology 2025 Mar 6;149:114190
International immunopharmacology 2025 Mar 6;149:114190
Impact of POU3F4 mutation on cochlear development and auditory function.
Dang J, Bian P, Chen C, Chen C, Shan W, Cai L, Li Y, Tan H, Xu B, Guan M, Guo Y
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
Cell communication and signaling : CCS 2025 Mar 5;23(1):121
The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1.
Peng B, Quan Z, Liang L, Liu M, Hu K, Chen S, Xie Q, Qin J, Chen J, Liao L, He S, Li Z
Scientific reports 2025 Mar 5;15(1):7672
Scientific reports 2025 Mar 5;15(1):7672
C-reactive protein-induced injury in Mycoplasma pneumoniae-infected lung epithelial cells is mediated by the P38 MAPK/mitochondrial apoptosis pathway.
Li L, Zhang Y, Zhao L, Shi Y
Microbiology spectrum 2025 Mar 4;13(3):e0162624
Microbiology spectrum 2025 Mar 4;13(3):e0162624
Single-Cell Sequencing Reveals the Heterogeneity of Hepatic Natural Killer Cells and Identifies the Cytotoxic Natural Killer Subset in Schistosomiasis Mice.
Xu F, Gao Y, Li T, Jiang T, Wu X, Yu Z, Zhang J, Hu Y, Cao J
International journal of molecular sciences 2025 Mar 30;26(7)
International journal of molecular sciences 2025 Mar 30;26(7)
Probiotic nanovesicles encapsulating baicalin: a strategy to overcome colorectal cancer.
Li Y, Zhao X, Wang D, Wang R, Zhu R, You X, Liu X, Li Y
Letters in applied microbiology 2025 Mar 3;78(3)
Letters in applied microbiology 2025 Mar 3;78(3)
Mechanistic Insights into Salvigenin for Glucocorticoid-Induced Femoral Head Osteonecrosis: A Network Pharmacology and Experimental Study.
Zhu Z, Zhong Y, He R, Zhong C, Chen J, Peng H
Biomedicines 2025 Mar 3;13(3)
Biomedicines 2025 Mar 3;13(3)
N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway.
Yang Y, Zhang X, Yang J, Wu Z, Li J, Song R, Meng C, Zhu G
Veterinary sciences 2025 Mar 3;12(3)
Veterinary sciences 2025 Mar 3;12(3)
Phenolics and Phenolic Glycosides from Wrightia pubescens and Their Hepatoprotective Activities.
Chen X, Yi P, Lv H, Zhang M, Yang J, Zhang Z, Zhao Z, Mu Y, Han L, Huang X
Journal of natural products 2025 Mar 28;88(3):631-643
Journal of natural products 2025 Mar 28;88(3):631-643
Bio-SS-TS as a Targeted Antitumor Drug Exerts an Anti-Liver Cancer Effect by Enhancing Mitochondria-Dependent Apoptosis.
Li J, Qin Y, Li M, Shang J, Chen H, Liu Y, Liu B, Zhou P, Zhao T, Wang G, Ge C, Zhang Y, Jia H, Ren F
Biological procedures online 2025 Mar 28;27(1):11
Biological procedures online 2025 Mar 28;27(1):11
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis.
Pekmez M, Mete ŞB, Aksüt Y, Öğütcü İ, Baştürk FN, Gerçek YC, Şengelen A
Medical oncology (Northwood, London, England) 2025 Mar 25;42(5):136
Medical oncology (Northwood, London, England) 2025 Mar 25;42(5):136
Berberine Exerts Neuroprotective Effects in Alzheimer's Disease by Switching Microglia M1/M2 Polarization Through PI3K-AKT Signaling.
Hu Y, Zhang P, Wang X
Physiological research 2025 Mar 24;74(1):129-140
Physiological research 2025 Mar 24;74(1):129-140
Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.
Bo C, Liu X, Liu Y, Xu L, Huang Q
European journal of medical research 2025 Mar 20;30(1):189
European journal of medical research 2025 Mar 20;30(1):189
MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells.
Chen J, Ji Z, Wu D, Wei S, Zhu W, Peng G, Hu M, Zhao Y, Wu H
Scientific reports 2025 Mar 17;15(1):9148
Scientific reports 2025 Mar 17;15(1):9148
S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis.
Han F, Dong Y, Liu Q, Song L, Guo H, Zhu L, Sun B, Zhao W, Chen L
Free radical biology & medicine 2025 Mar 16;230:66-78
Free radical biology & medicine 2025 Mar 16;230:66-78
MiR-222-3p loaded stem cell nanovesicles repair myocardial ischemia damage via inhibiting mitochondrial oxidative stress.
Liu M, Wang L, Liu Z, Liu D, Li T, Ding L, Zeng S, Wang Z, Wang J, Zhang F, Zhang J, Zhang L, Li M, Liu G, Wang X, Zheng M
Life sciences 2025 Mar 15;365:123447
Life sciences 2025 Mar 15;365:123447
The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway.
Zhang H, Xu Z, Xu Z, Bian S, Qiao N, Wang X, Zhang M, Zhang M, Zhen X, Wu D, Xu H
European journal of medicinal chemistry 2025 Mar 15;286:117291
European journal of medicinal chemistry 2025 Mar 15;286:117291
The mechanism of Se in regulating the proliferation and apoptosis of sheep Leydig cells through the miR-200a/NRF2 pathway.
Li K, Wang X, Ma L, Ren Y, Shi L
Theriogenology 2025 Mar 15;235:103-113
Theriogenology 2025 Mar 15;235:103-113
Exercise preconditioning increases circulating exosome miR-124 expression and alleviates apoptosis in rats with cerebral ischemia-reperfusion injury.
Song W, Teng L, Wang H, Pang R, Liang R, Zhu L
Brain research 2025 Mar 15;1851:149457
Brain research 2025 Mar 15;1851:149457
LXRα agonists ameliorates acute rejection after liver transplantation via ABCA1/MAPK and PI3K/AKT/mTOR signaling axis in macrophages.
Qin X, Hu D, Li Q, Zhang S, Qin Z, Wang L, Liao R, Wu Z, Liu Y
Molecular medicine (Cambridge, Mass.) 2025 Mar 14;31(1):99
Molecular medicine (Cambridge, Mass.) 2025 Mar 14;31(1):99
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Mechanism of Marsdenia tenacissima in treating breast cancer by targeting the MAPK signaling pathway: Utilising metabolomics, network pharmacology, and In vivo experiments for verification.
Su X, Li R, Zhang Z, Lu L, Wang S, Liu T
Journal of ethnopharmacology 2025 Mar 13;343:119477
Journal of ethnopharmacology 2025 Mar 13;343:119477
Dual-responsive stem cell microspheres modified with BDNF for enhanced neural repair in diabetic erectile dysfunction.
Pan X, Xing X, Ji Z, Zhang J, Chen Q, Yin W, Zang Y, Yang Y, Liu Z, Xu Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Mar 10;379:409-420
Journal of controlled release : official journal of the Controlled Release Society 2025 Mar 10;379:409-420
Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.
Ji X, Ding H, Zhou F, Zhang F, Wu D
Ecotoxicology and environmental safety 2025 Mar 1;292:117938
Ecotoxicology and environmental safety 2025 Mar 1;292:117938
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.
Ding X, Chen C, Zhao H, Dai B, Ye L, Song T, Huang S, Wang J, You T
Neural regeneration research 2025 Mar 1;20(3):858-872
Neural regeneration research 2025 Mar 1;20(3):858-872
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
Guo D, Pang Y, Wang W, Feng Y, Wang L, Sun Y, Hao J, Li F, Zhao S
Cells 2025 Mar 1;14(5)
Cells 2025 Mar 1;14(5)
Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway.
Wang F, Li J, Zhang Z, Huang G, Zhang X, Liu Q, Xiao W, Liu F, Sun J, Liu Y, Ma Y, Zhuang R, Du Y, Wang X, Gao C, Gu X
Tissue & cell 2025 Jun;94:102795
Tissue & cell 2025 Jun;94:102795
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
Zhang B, Hou J, Dong L, Sun M, Dong Y, Dong Y
Cytotechnology 2025 Jun;77(3):121
Cytotechnology 2025 Jun;77(3):121
LINC02154 Promotes Esophageal Squamous Cell Carcinoma Progression via the PI3K-AKT-mTOR Signaling Pathway by Interacting With IGF2BP2.
Zhang M, Zhang C, Zhou F, Yang R, Feng Y, Ji Y, Ren H, Ming L
Molecular carcinogenesis 2025 Jun;64(6):985-996
Molecular carcinogenesis 2025 Jun;64(6):985-996
OSBP Participates in Neural Damage Repair by Regulating Lysosome Transport Under Oxidative Stress.
Fei M, Luo S, Gao C, Huang X, Wang L, Jin T, Liu M, Zhou M, Wang H
Molecular neurobiology 2025 Jun;62(6):7557-7575
Molecular neurobiology 2025 Jun;62(6):7557-7575
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Lin J, Sun Y, Huang H, Yu C, Kuang W, Wang Y, Zhu L
Molecular neurobiology 2025 Jun;62(6):7054-7074
Molecular neurobiology 2025 Jun;62(6):7054-7074
Melatonin ameliorates PM2.5-induced airway inflammation and apoptosis by PERK/eIF2α/ATF4/CHOP in chronic obstructive pulmonary disease mice.
Shi M, Liu K, Li X, Zeng XL, Liu XJ
Toxicology and applied pharmacology 2025 Jun;499:117314
Toxicology and applied pharmacology 2025 Jun;499:117314
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Madecassoside mitigates acute myocardial infarction injury by activating the PKCB/SPARC signaling pathway.
Wang P, Yang JQ, Xu DD, Zhang SJ, Lu S, Ji Y
Acta pharmacologica Sinica 2025 Jun;46(6):1624-1638
Acta pharmacologica Sinica 2025 Jun;46(6):1624-1638
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Weijia LI, Jing LU, Chao MA, Mengmeng L, Ke P, Hongyan C, Zhe L, Guangfu L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Zhao HM, Mu LQ, Wang J, Chen RZ, Li Y, Zhao L, Zhao Y, Liu LN
Current medical science 2025 Jun;45(3):469-480
Current medical science 2025 Jun;45(3):469-480
Nab-Paclitaxel Promotes Radiosensitization by Inducing DNA Damage and Inhibiting Macrophage M2 Polarization in Cholangiocarcinoma.
Wang N, Mei X, Cao Y, Wang L, Xie H, Jia J, Xiao Y, Han J, Huang A, Ma H
Cancer biotherapy & radiopharmaceuticals 2025 Jun;40(5):352-363
Cancer biotherapy & radiopharmaceuticals 2025 Jun;40(5):352-363
Elucidating the anticancer potential of dendrobine in renal cell carcinoma treatment.
Jia X, Chen Z, Chen X, Zhang H, Sun Z, Wang Z, Liu M
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7517-7528
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7517-7528
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Zhang M, Liu R, Jiang W, Li H, Zhang S, Cheng W, Ye X, He J, Liu Y, Jing A, Song Y, Wang D, Liu X, Zhang B, Wang X, Ji J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Combined Ribociclib and NU7026 administration enhances radio-sensitivity by inhibiting DNA repair in prostate cancer.
Sun J, Wang Y, Ma S, Zhang W, Yang L, Zhang B, Tang Q
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7075-7085
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7075-7085
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Wei HK, Qi JJ, Wang YQ, Qu HX, Yan CX, Li TT, Wang Y, Sun H, Sun BX, Liang S
Animal bioscience 2025 Jun;38(6):1160-1174
Animal bioscience 2025 Jun;38(6):1160-1174
Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma.
Zhao Q, Liu S, Bi T, Wang T, Chen L, Huang J, Yang X, Dai X, Liu Z, Sun Q
Materials today. Bio 2025 Jun;32:101940
Materials today. Bio 2025 Jun;32:101940
Fe-curcumin nanozymes-mediated reactive oxygen species scavenging and anti-apoptotic effects on age-related cataracts.
Gao X, Li K, Huang Y, Long Z, Xiang Y, Zheng W, Cheng H, Cao H, Wan W, Zheng S, Wang X, Hu K
Materials today. Bio 2025 Jun;32:101850
Materials today. Bio 2025 Jun;32:101850
Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects.
Li X, Zhang J, Zhang Y, Guo L, Gao M, Wang Y, Qiu W, Yuan Y, Zhu J, Liu B, Xiong H, Xu T, Xu R
Materials today. Bio 2025 Jun;32:101639
Materials today. Bio 2025 Jun;32:101639
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Luo B, Cai M, Huang H, Zhang Y, Chen P, Ji R, Wang F, Liao P, Xian M
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.
Hu L, Ma H, Yang C, Wang K, Ji X, Xu T, Xu H, Zhao Y, Zhen Y
International journal of biological macromolecules 2025 Jun;311(Pt 4):144083
International journal of biological macromolecules 2025 Jun;311(Pt 4):144083
Polygonatum cyrtonema polysaccharide alleviates dopaminergic neuron apoptosis in Parkinson's disease mouse model via inhibiting oxidative stress and endoplasmic reticulum stress.
Li QM, Xu H, Zha XQ, Zhang FY, Luo JP
International journal of biological macromolecules 2025 Jun;311(Pt 3):143986
International journal of biological macromolecules 2025 Jun;311(Pt 3):143986
Single-Cell RNA Sequencing and Spatial Transcriptomics Reveal a Novel Mechanism of Oligodendrocyte-Neuron Interaction in Cognitive Decline After High-Altitude Cerebral Edema.
Lv W, Ma Y, Li D, Xiong K, Cui J, Pan S, Zhang N, Li Y, Chen Y, Guo D
CNS neuroscience & therapeutics 2025 Jun;31(6):e70485
CNS neuroscience & therapeutics 2025 Jun;31(6):e70485
Potential of recombinant CAV1-Fc in the treatment of ApxI toxin-induced damage by Actinobacillus pleuropneumoniae.
Hu Y, Zhang M, Yang G, Guo H, Jiang C, Zhou P, Chen Y, Zhang M, Ghonaim AH, Li W, He Q
Veterinary microbiology 2025 Jun;305:110504
Veterinary microbiology 2025 Jun;305:110504
Inhibition of SIRT1/HSF1 pathway contributes to doxorubicin-induced nephrotoxicity in ovarian tumor-bearing mice.
Chen M, Zhao Y, Hu S, Yuan JB, Xie KJ, Cai SN, Zhu XY, Du JK, Xu PB
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1572-1588
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1572-1588
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Zhou Y, Chen W, Feng S, Liu S, Chen C, Yao B, Shen XL
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
CCDC134 enhances ovarian reserve function and angiogenesis by directly interacting with INHA in a mouse model of premature ovarian insufficiency.
Cui X, Li H, Zhu X, Huang X, Xue T, Wang S, Jing X
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1311-1330
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1311-1330
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
Li W, Yin Q, Qiu Y, Liu J, Wang J, Li C, Zhang D, Zhang P, Lv H, Lv Y, Wang Y
Cancer genetics 2025 Jun;294-295:156-170
Cancer genetics 2025 Jun;294-295:156-170
LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis.
Liu B, Lu T, Zhang G, Dong X, Yu M, Cai H
Journal of cellular and molecular medicine 2025 Jun;29(11):e70652
Journal of cellular and molecular medicine 2025 Jun;29(11):e70652
Tripterygium wilfordii polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner.
Ren PY, Zhang JY, Zhao L, Sun XJ
Journal of Asian natural products research 2025 Jun;27(6):929-949
Journal of Asian natural products research 2025 Jun;27(6):929-949
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate.
Li P, Wu M, Wang R, Zhang G, Kang L, Guan H, Ji M
Experimental eye research 2025 Jun;255:110361
Experimental eye research 2025 Jun;255:110361
Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.
Fang L, Li W, Zhao H, Wang W, Gao H, Wang P, Zhang X, Lv R, Xu F, Chen J, Lyu L, Chen Y
Biochemical pharmacology 2025 Jun;236:116870
Biochemical pharmacology 2025 Jun;236:116870
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Luo Z, Zheng S, Hu Z, Li P, Zeng J, Lu Y, Ali M, Chen Z, Wang Q, Qi F
Free radical biology & medicine 2025 Jun;233:302-316
Free radical biology & medicine 2025 Jun;233:302-316
Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice.
Ding Y, Yao S, Guo S, Meng W, Li J, Wang F, Zhang J, Chang YZ, Gao G
Pharmacological research 2025 Jun;216:107778
Pharmacological research 2025 Jun;216:107778
Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1.
Ren J, Xie L, Zhu X, Chen X, Wei L, Xu D, Qiao K, Min S, Ding Y, Tan Y
Cytokine 2025 Jun;190:156930
Cytokine 2025 Jun;190:156930
Macrophages-derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression.
Tu M, Liu AM, Huang W, Wang D, Chen HQ, Hu XY
Journal of cell communication and signaling 2025 Jun;19(2):e70008
Journal of cell communication and signaling 2025 Jun;19(2):e70008
Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2.
Wu H, Ning Y, Sun Z, Ji J, Lu M, Jiao X, Xu X, Ding X, Cheng X, Yu X
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167754
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167754
Curcumol Ameliorates Cisplatin-induced Nephrotoxicity by Targeting TAK1 and Inhibiting MAPK and NF-κB Pathways.
Jin X, Yuan M, Wang L, Zha H, Zheng Z, Xu Z, Shi J, Liang G, Zhou Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156752
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156752
Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury.
Xu C, Wang H, Wang H, Man J, Deng Y, Li Y, Cheng K, Niu J, Gui H, Fu S, Yang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156672
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156672
Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway.
Li X, Hua D, Wu D, Hong W, Kang Y, Tang L, Yang Q, Wang X, Li B, Li R, Chen Z, Cui G
Cancer medicine 2025 Jun;14(11):e70987
Cancer medicine 2025 Jun;14(11):e70987
Hsp70 incompletely disaggregates misfolded K488X-menin to promote tumourigenesis in a family with multiple endocrine neoplasia type 1.
Zeng Z, Zhang Q, Liang T, Xiong Y, Liu Z, Zhang J, Yang P, Yang J, Lu Q, Shen D, Tian H, Zhou Z, Fang W, Zhang M, Liu Q, Gao B, Wei Y, Zhou D
Cellular signalling 2025 Jun;130:111681
Cellular signalling 2025 Jun;130:111681
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
Cheng N, Luo Q, Yang Y, Shao N, Nie T, Deng X, Chen J, Zhang S, Huang Y, Hu K, Luo L, Xiao Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(24):e2410590
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(24):e2410590
Luteolin ameliorates kainic acid-induced seizure by modulating GADD45B and reducing oxidative stress in hippocampal neurons.
Luo C, Wang Z, Liao J, Fu C, Zhang F, Zhao J
Neuropeptides 2025 Jun;111:102524
Neuropeptides 2025 Jun;111:102524
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Feng X, Tian Y, Guo X, Lei JH, Yu J, Zheng C, Chen M, Ding RB, Kwok HF, Luo S, Bao J
Biomolecules 2025 Jun 8;15(6)
Biomolecules 2025 Jun 8;15(6)
Polypyrrole-ferric phosphate-methotrexate nanoparticles enhance apoptosis/ferroptosis of M1 macrophages via autophagy blockage for rheumatoid arthritis treatment.
Liu H, Wan H, Zhang A, Ouyang Y, Lu X, Wu M, Hu N, Pan J, Guo D, Li ZA, Xie D
Journal of nanobiotechnology 2025 Jun 7;23(1):428
Journal of nanobiotechnology 2025 Jun 7;23(1):428
Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria.
Wang Y, Cui Y, Liu Z, Liu L, Huang Z, Wang Q, Mao X
European journal of pharmacology 2025 Jun 5;996:177572
European journal of pharmacology 2025 Jun 5;996:177572
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.
Wang Y, Jiang L, Tian JJ, Zhu LL, Dai HJ, Guo C, Zhou LY, Wang L, Lu Y, Zhang Y
Neurochemical research 2025 Jun 5;50(3):180
Neurochemical research 2025 Jun 5;50(3):180
Ergosterol Protects Canine MDCK Cells from Gentamicin-Induced Damage by Modulating Autophagy and Apoptosis.
Qin Z, Xie L, Wang Y, Zhang N, Bi H, Song M, Xu C
Metabolites 2025 Jun 5;15(6)
Metabolites 2025 Jun 5;15(6)
GPR43 regulates mitochondrial apoptosis through the cyclophilin D pathway in Alzheimer's disease.
Wang X, Wu S, Deng Z, Yan M, Wang D, Yang M, Zhong F, Song J, Chen L, Chen Y, Tian Q, Yu W, Lü Y
Molecular medicine (Cambridge, Mass.) 2025 Jun 4;31(1):219
Molecular medicine (Cambridge, Mass.) 2025 Jun 4;31(1):219
Huangqi fuling decoction inhibits the invasion and metastasis of gastric cancer via the TNF signaling pathway.
Luo Y, Ruan J, Zhang J, Zhang S, Zhang M, Tian Y, Wang W, Wang J, Ma C, Wang J
Scientific reports 2025 Jun 4;15(1):19628
Scientific reports 2025 Jun 4;15(1):19628
Characterization of T cell proliferation-associated hepatocellular carcinoma subtypes, predictive signatures, and candidate targets.
Yang Q, Liu L, Zhu Y, Shen Z, Xu Y, Zhang M, Chen X
Journal of gastrointestinal oncology 2025 Jun 30;16(3):1127-1143
Journal of gastrointestinal oncology 2025 Jun 30;16(3):1127-1143
TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.
Shi Y, Huang M, Zhou W, Zhao Y, Zhao J, Zhong B, French SW, Tang X, Liu H
Journal of translational medicine 2025 Jun 3;23(1):621
Journal of translational medicine 2025 Jun 3;23(1):621
Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.
Xiao W, Yang Y, Bai L, Yang P, Li R, Yang D, Li F, Quan L, Liang Q, Yan Y, Qi T, Liang F
Journal of neuroinflammation 2025 Jun 28;22(1):168
Journal of neuroinflammation 2025 Jun 28;22(1):168
Pharmacological Intervention with 4-Phenylbutyrate Ameliorates TiAl6V4 Nanoparticles-Induced Inflammatory Osteolysis by Promoting Macrophage Apoptosis.
Liu G, Gong H, Bai T, Fu Y, Li X, Lu J, Zhao J, Chen J
Bioengineering (Basel, Switzerland) 2025 Jun 27;12(7)
Bioengineering (Basel, Switzerland) 2025 Jun 27;12(7)
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Wu M, Wu X, Sun H, Wang W, Zhang L, Liu X, Zhang Y, Zhang X, Liu J, Shen B, Zhou T
Science advances 2025 Jun 27;11(26):eadq9643
Science advances 2025 Jun 27;11(26):eadq9643
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
Chuanxiong-Danggui herb pair alleviated cognitive deficits of APP/PS1 mice by promoting mitophagy.
Pu K, Yang S, Sheng R, Chen J, Dai Y, Wood IC, Zhong Z, Xu S
Journal of ethnopharmacology 2025 Jun 26;350:119988
Journal of ethnopharmacology 2025 Jun 26;350:119988
Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway.
Qiu XF, He CM, Zeng YM, Deng XL, Liang GL, Zhong MX, Zou M, Xiong XJ, Zhang JD, Ye Y, Niu Q, Chen XL
iScience 2025 Jun 20;28(6):112634
iScience 2025 Jun 20;28(6):112634
Photothermal Hyperthermia Suppresses Liver Tumor Growth Via Hippo Signaling Pathway-Dependent Inhibition of Cell Proliferation and Induction of Apoptosis.
Li J, Qin Y, Yang Y, Chen H, Li M, Liu Y, Liu B, Shang J, Zhang Y, Han T, Hu Y, Ren F
Biological procedures online 2025 Jun 17;27(1):22
Biological procedures online 2025 Jun 17;27(1):22
Human neural stem cell-derived small extracellular vesicles enhance functional recovery after ischemic stroke through the miR-362-3p/MCAM/Wnt/β-catenin axis.
Zhu Z, Zhang G, Ahmed W, Feng J, Wang C, Zhang Y, Wu G, Hong C, Zhang Q, Feng T, Liu J, Zhao A, Chen L
International immunopharmacology 2025 Jun 17;158:114826
International immunopharmacology 2025 Jun 17;158:114826
Development of Theranostic (177)Lu-Labeled Polymeric Nanoparticles ((177)Lu-PNPs) for the Treatment of Head and Neck Cancer.
Hsieh HH, Su SP, Chan YH, Chiang HK, Lee YJ, Wu CY
ACS applied bio materials 2025 Jun 16;8(6):5266-5275
ACS applied bio materials 2025 Jun 16;8(6):5266-5275
The miR-21-5p/DUSP8/MAPK signaling pathway mediates inflammation and apoptosis in vascular endothelial cells induced by intermittent hypoxia and contributes to the protective effects of N-acetylcysteine.
Zhao Y, Lv R, He Y, Dong N, Wang X, Pu J, Yu Q
European journal of pharmacology 2025 Jun 15;997:177462
European journal of pharmacology 2025 Jun 15;997:177462
The development of pyridazinone-based andrographolide derivatives as anti-cancer agents with the ability of inhibiting the TFAP4/Wnt/β-catenin signaling pathway.
Zhang H, Xu Z, Xu Z, Bian S, Qiao N, Wang X, Zhang M, Guo F, Cui Y, Zheng F, Liu J, Wu D, Xu H
Bioorganic chemistry 2025 Jun 15;160:108440
Bioorganic chemistry 2025 Jun 15;160:108440
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
Zeng F, Wang M, Li Z, Zhang Y
Medicine 2025 Jun 13;104(24):e42763
Medicine 2025 Jun 13;104(24):e42763
KLF4 mediates the contradictory effects of phenylethyl isothiocyanate in gastric cancer intervention.
Zhang Q, Yang C, Zhou B, Gao X, Zhong C, Shi Y, Cao H, Zhu M
Medical oncology (Northwood, London, England) 2025 Jun 12;42(7):253
Medical oncology (Northwood, London, England) 2025 Jun 12;42(7):253
PELI2 inhibits colorectal cancer development through MAPK signaling pathway.
Liu J, Hu S, Zhao L, Yang Y, Wu G, Duan Y, Ma X, Wang P, Zhang Z, Zong H
Molecular medicine (Cambridge, Mass.) 2025 Jun 12;31(1):235
Molecular medicine (Cambridge, Mass.) 2025 Jun 12;31(1):235
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62
Bone research 2025 Jun 12;13(1):62
A Carrier-Free Triple-Drug Co-Assembled Nanoformulation for Synergistic Treatment of Cerebral Ischemia-Reperfusion Injury.
Guo Y, Jia M, He Q, Zeng J, Zhang Y, Gao Y, Zhao Z, Malashicheva A, Miao W, Zhao J, Wang G, Wang Y
ACS applied materials & interfaces 2025 Jun 11;17(23):33618-33632
ACS applied materials & interfaces 2025 Jun 11;17(23):33618-33632
Poly-lysine-modified recombinant protein nanocages for effective delivery of small activating RNA.
Xu L, Li S, Wan S, Liu Z, Zhong Y, Qian X, Qin J, Cai L, Huang H
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113638
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113638
Molecular mechanism of rapamycin-induced autophagy activation to attenuate smoking-induced COPD.
Wang L, Jia J, Yu X, Luo M, Li J, Khan GJ, He C, Duan H, Zhai K
Biochemical and biophysical research communications 2025 Jun 1;764:151819
Biochemical and biophysical research communications 2025 Jun 1;764:151819
Muscle-derived factor alleviated cognitive impairment caused by intestinal ischemia-reperfusion.
Tan Y, Mu G, Wang F, Fan X, Yang C, Shi Z, Bai Y, Xie B, Yu X, Feng J, Jia J, Wang X, Chen Y, Zhou J
Redox biology 2025 Jul;84:103682
Redox biology 2025 Jul;84:103682
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Wang X, Sun X, Zhang X, Shen N, Xia J, Wang L, Ye S
Archives of biochemistry and biophysics 2025 Jul;769:110433
Archives of biochemistry and biophysics 2025 Jul;769:110433
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Ding Y, Zhang L, Zhao W, Wang T, Shi Y, Zhuang C, Qu Z
Molecular nutrition & food research 2025 Jul;69(13):e70103
Molecular nutrition & food research 2025 Jul;69(13):e70103
MiR-124 Delivered by Extracellular Vesicles from Mesenchymal Stem Cell Exerts Neuroprotective Effects by Stabilizing the p62-Keap1-Nrf2 Pathway after Spinal Cord Injury in Rats.
Fang C, Qian J, Tu BZ, Xia X, Jia CY, Shen CL
Molecular neurobiology 2025 Jul;62(7):8328-8340
Molecular neurobiology 2025 Jul;62(7):8328-8340
Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia.
Zhang R, Xie Y, Zhang M, Li Z, Guo L, Wei H, Li X, Xin J, Yang Z, Wen Y, Hao J, Li X, Yin X, Jiang W, Bi H, Guo D
Experimental & molecular medicine 2025 Jul;57(7):1536-1554
Experimental & molecular medicine 2025 Jul;57(7):1536-1554
Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11.
Zhou P, Sun F, Lin P, Yan Y, Liu J, Zhou Y, He T, Liu P, Wang J, Sun H, Ma H
Translational oncology 2025 Jul;57:102404
Translational oncology 2025 Jul;57:102404
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response.
Zhang QH, Jin LM, Lin MS, Wang MX, Cui YQ, Ye JX, Xiong YQ, Luo W, Zhu WW, Liang G
Acta pharmacologica Sinica 2025 Jul;46(7):1946-1957
Acta pharmacologica Sinica 2025 Jul;46(7):1946-1957
Metformin Improves Palmitate-Induced Follicular Granulosa Cell Dysfunction by Activating ULK1-Mediated Autophagy.
Heng N, Hao H, Hu Y, Wang Y, Wang H, He W, Zhu N, Wang R, Xuan X, Zhu H, Zhao S, Wang F
Reproductive sciences (Thousand Oaks, Calif.) 2025 Jul;32(7):2442-2452
Reproductive sciences (Thousand Oaks, Calif.) 2025 Jul;32(7):2442-2452
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Wang H, Cheng G, Zhang S, Qu H, Zhao X, Yang A, Sun X, Pan H
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Ma MQ, Yang C, Jin SY, Yang Y, Pan YY, Lin XH
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Exploration of the Potential Bioactive Compounds and Functional Mechanism of Chaihu Sanshen Capsule in Ameliorating Myocardial Ischaemia-Reperfusion Injury: A Serum Pharmaco-Chemistry With Network Pharmacology Analysis.
Wang W, Zhang Z, Liu R, Zheng Y, Hu Y, Li X, Shen Z, Yuan H, Liu J
Journal of cellular and molecular medicine 2025 Jul;29(14):e70666
Journal of cellular and molecular medicine 2025 Jul;29(14):e70666
Neutralization of IL-33 ameliorates septic myocardial injury through anti-inflammatory, anti-oxidative, and anti-apoptotic by regulating the NF-κB/STAT3/SOCS3 signaling pathway.
Weng D, Shi W, Hu Y, Su Y, Li A, Wei S, Guo S
Biochemical pharmacology 2025 Jul;237:116954
Biochemical pharmacology 2025 Jul;237:116954
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Xiang J, Yue H, Jiang D, Zheng S, Wu Z
Biochemical pharmacology 2025 Jul;237:116929
Biochemical pharmacology 2025 Jul;237:116929
Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro.
Wang H, Wang Y, Zhong Y, Yu B, Liu D, Jia C, Wu J, Zeng G, Wang Q, Liu F, Sheng C, Huang L
Free radical biology & medicine 2025 Jul;234:233-247
Free radical biology & medicine 2025 Jul;234:233-247
Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.
Xie S, Yin M, Xiang M, Shao L, Zhang N, Shi L, Zhang J, Yu G
Biological trace element research 2025 Jul;203(7):3820-3832
Biological trace element research 2025 Jul;203(7):3820-3832
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
Du C, Zhu Y, Duan J, Yang Y, Ren Y, Mu L, Yan Z, Li G, Wang H, Shi Y, Yao F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118217
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118217
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Li XJ, Huang KX, Wang KX, Liu R, Wang DC, Liang YR, Hao EJ, Wang Y, Guo HM
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
CD11b Blockade Ameliorates Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil and Monocyte Infiltration.
Fu P, Han X, Lin QY, Wang N, Sun FF, Zhang YL, Li HH, Zhang B
Journal of the American Heart Association 2025 Jul;14(13):e038142
Journal of the American Heart Association 2025 Jul;14(13):e038142
ALA Alleviates Liver Damage in Septic Mice Through PI3K/AKT Signaling Pathway.
Song Y, Mao Y, Sui Q, Zhao Z, Dong D
Food science & nutrition 2025 Jul;13(7):e70599
Food science & nutrition 2025 Jul;13(7):e70599
A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma.
Xu R, Zhu S, Zhang W, Xu H, Tu C, Wang H, Wang L, He N, Liu T, Guo X, Ren X, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2500632
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2500632
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization.
Xuan C, Chen D, Zhang S, Li C, Fang Q, Chen D, Liu J, Jiang X, Zhang Y, Shen W, Cai G, Chen X, Li P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414587
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414587
Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α.
Gao T, Tang Y, Zeng T, Wang J, Zhang X, Liu Q, Guan X, Tang X, Lu G, Li J, Liu M, Zhang D, Lv S, Gu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414504
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414504
Embryonic stem cell-derived small extracellular vesicles alleviate lead-induced cochlear spiral ganglion neurons injury by activating PI3 K/AKT signaling pathway.
Wang L, Bai Y, Sun Y, Li L, He Y, Li G, Liu D, Huang Z, Song J, Wu H, Li H, Wu X
Science progress 2025 Jul-Sep;108(3):368504251358007
Science progress 2025 Jul-Sep;108(3):368504251358007
Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule (CP) on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification.
Wang S, Lai Y, Huang H, Yuan J, Li S, Hui M, Wang P, Chen B, Liu Z, Qian J, Zhang Q
Acta biochimica et biophysica Sinica 2025 Jul 9;57(11):1803-1813
Acta biochimica et biophysica Sinica 2025 Jul 9;57(11):1803-1813
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction.
Lu Z, Chai Q, Dai W, Yu B, Lv Q, Qiu F, Gao J, Zhang J, Shen X, Chen S, Shen Z, Shang M, Zhang W, Fu G, Jin Q, Zhao Y, Jia F
Journal of nanobiotechnology 2025 Jul 8;23(1):496
Journal of nanobiotechnology 2025 Jul 8;23(1):496
HOXD13 knockdown attenuates apoptosis in prostate cancer via the upregulation of MDM2/p53 signaling.
Ma Y, Qi P, Ren Z, Liu R, Wei S, Zhang A
Cell division 2025 Jul 6;20(1):18
Cell division 2025 Jul 6;20(1):18
Targeting Eg5 using Arry520 combats gastric cancer by inducing monopolar spindles.
He N, Wei X, Sun R, Zhang G, Zhao J, Jiang X, Long B, Yu Z, Shi W, Jiao Z
Gene 2025 Jul 5;955:149458
Gene 2025 Jul 5;955:149458
Galangin Regulates Oxidative Stress Levels in Porcine Embryos Through Interaction with the Neh1 Domain of Nrf2.
Chi ZC, Shi SM, Liu LY, Qu LY, Li JH, Jia GL, He YY, Li LX, Jin YX, Zhang MJ, Yu XF
Antioxidants (Basel, Switzerland) 2025 Jul 4;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 4;14(7)
Neferine induces cell growth inhibition and apoptosis via ROS-mediated activation of p38 in pancreatic ductal adenocarcinoma cells.
Zhou X, Chen M, Xing R, Yang F, Liu H, Liang S
Journal of molecular histology 2025 Jul 31;56(4):246
Journal of molecular histology 2025 Jul 31;56(4):246
EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines.
Xu B, Liang X, Liu W, Wu B, Wang Q, Kai G, Han C, Sun B, Dong B, Dong C, Wang L
Hereditas 2025 Jul 31;162(1):148
Hereditas 2025 Jul 31;162(1):148
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
Su J, Zhao Y, Li M, Chen G, Liu C, Idris A, Ma Z, Zhang H
Scientific reports 2025 Jul 30;15(1):27850
Scientific reports 2025 Jul 30;15(1):27850
RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis.
Feng J, Zheng B, Wang J, Xu Q, Ouyang Q, Li H, Jia T, Wang Y, Cai T, Feng Y, Zhang X, Li X, Ma X
Translational andrology and urology 2025 Jul 30;14(7):1849-1864
Translational andrology and urology 2025 Jul 30;14(7):1849-1864
miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis.
Huang SH, Liu ZM, Chen SJ, Tu PY, Tien YC, Lu CC, Wang CC, Chen LM, Shen PC
Cartilage 2025 Jul 30;:19476035251361679
Cartilage 2025 Jul 30;:19476035251361679
Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer.
Ma X, Cheng M, Jia Y, Zhang K, Zhang H, Feng D, Xu W, Qiao G
Cell death discovery 2025 Jul 3;11(1):305
Cell death discovery 2025 Jul 3;11(1):305
Annexin A2: regulating glioma's fate and a potential therapeutic target.
Liu W, Zhao X, Regmi M, Shamsutdinova MI, Shamsutdinov M, Liu S, Dai Y, Wang Y, Liu H, Wu J, Yang J, Yang C, Sino-Uzbek Regenerative Therapy Consortium (SURE)
Medical oncology (Northwood, London, England) 2025 Jul 28;42(9):386
Medical oncology (Northwood, London, England) 2025 Jul 28;42(9):386
Xanthosine alleviates myocardial ischemia-reperfusion injury through attenuation of cardiomyocyte ferroptosis.
Xu Y, Zhou W, Fan Z, Cheng Y, Xiao Y, Liu Y, Li X, Ji Z, Fan Y, Ma G
Cellular & molecular biology letters 2025 Jul 28;30(1):93
Cellular & molecular biology letters 2025 Jul 28;30(1):93
Gallic Acid and Taurine Attenuate Thiamethoxam-Induced Hepatotoxicity in Rats by Modulating SIRT-1/PGC-1α, NF-κB/iNOS, and p53/Bax/Caspase-3 Pathways.
Elazab ST, Safhi FA, Al-Akeel RK, Deraz RH, Sarkar S, Gamal Eldin REA
Pharmaceuticals (Basel, Switzerland) 2025 Jul 25;18(8)
Pharmaceuticals (Basel, Switzerland) 2025 Jul 25;18(8)
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment.
Wang X, Wang C, Ma Y, Piao Y, Shi Y, Yang S, Li J, Fan Y
Journal of medicinal chemistry 2025 Jul 24;68(14):14569-14593
Journal of medicinal chemistry 2025 Jul 24;68(14):14569-14593
Mechanistic exploration of Dahuang Zhechong Pill against hepatic fibrosis via integrated serum pharmacochemistry, UHPLC-ESI-QTOF-MS/MS, network pharmacology, and molecular docking with cellular and zebrafish validation.
Li M, Deng K, Li Y, Xiang L, Wang Y, Shi H, Kuang S, Wen J, Zhou C, Lv Z, Huang S
Journal of ethnopharmacology 2025 Jul 24;351:120102
Journal of ethnopharmacology 2025 Jul 24;351:120102
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Zhao Z, Li J, Song N, Gao H, Liu D, Jin Z, Chen Y, Guo X, Liu Z, Yang X
Journal of ethnopharmacology 2025 Jul 24;351:119967
Journal of ethnopharmacology 2025 Jul 24;351:119967
Heat stress affects expression levels of circadian clock gene Bmal1 and cyclins in rat thoracic aortic endothelial cells.
Chang X, Zhang H, Cao H, Hou L, Meng X, Tao H, Luo Y, Li G
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Jul 20;45(7):1353-1362
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Jul 20;45(7):1353-1362
Non-invasive assessment of stem cell DNA integrity in response to environmental stressors.
Wang J, Zhou Y, Zhuo L, Yan B, Ma L
Scientific reports 2025 Jul 2;15(1):22960
Scientific reports 2025 Jul 2;15(1):22960
A LINC00472-encoded polypeptide impedes migration and proliferation through modulation of the HDAC2/SP1 axis in non-small cell lung cancer cells.
Xu L, Kuang H, Peng H, Wu S, Bai Y, Jia X, Yao W
Cancer cell international 2025 Jul 16;25(1):263
Cancer cell international 2025 Jul 16;25(1):263
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Zheng W, Liu Y, Liu J, Zhao Y, Wang P, Wang Y, Wang Y, Lu Z, Liu X, Shi Y, Zhou N, González FE, Sun H, Zhou D, Xu X
Journal of colloid and interface science 2025 Jul 15;690:137337
Journal of colloid and interface science 2025 Jul 15;690:137337
Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway.
Tu Y, Xiong Y, Liu O, Peng Y
Experimental cell research 2025 Jul 15;450(2):114658
Experimental cell research 2025 Jul 15;450(2):114658
MS275 Inhibits Neuroblastoma Cell Growth by Mediating H3K27ac/PROX1 Axis In Silico and In Vitro.
Yuan C, Li C, Lu J, Liao S, Wu R, Li D, Huang M, Gong D, Wu W, Yu X, Fei S, Si W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70797
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70797
p-phenoxyphenol impaired male fertility by disrupting the testicular function and local microenvironment.
Han X, Jiang D, Li Q, Li P, Chao L, Yang Y
Ecotoxicology and environmental safety 2025 Jul 15;300:118436
Ecotoxicology and environmental safety 2025 Jul 15;300:118436
SIRT5 alleviates oxidative stress of boar sperm induced by cryopreservation through IDH2 and SOD2 pathway.
Ali MA, Zhang Y, Ni Q, Huang AQ, Dou S, Tang Y, Xu X, Zeng C
Theriogenology 2025 Jul 15;241:117424
Theriogenology 2025 Jul 15;241:117424
Organic cation transporter 3 on neuronal mitochondria mediates MPP(+)-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner.
Guan A, Han S, Liang S, Shen W, Guo M, Cui M
BMC biology 2025 Jul 15;23(1):214
BMC biology 2025 Jul 15;23(1):214
Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.
Gao Y, Bao S, Wen B, Li H, Guo Q, Li A, Bao L, Li M, Han B
Functional & integrative genomics 2025 Jul 11;25(1):154
Functional & integrative genomics 2025 Jul 11;25(1):154
Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death.
Du J, Wang X, Zeng Y, Feng J, Yang L, Huang Y, Deng G
Scientific reports 2025 Jul 11;15(1):25012
Scientific reports 2025 Jul 11;15(1):25012
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Ye Y, Shen F, Yan M, Zhan C, Lv J, Zou M, Wang Z, Ning S, Gao Y, Wu J, Li W
Cell death & disease 2025 Jul 10;16(1):509
Cell death & disease 2025 Jul 10;16(1):509
Biomimetic cancer cell membrane engineered lipid nanoparticles for enhanced chemotherapy of homologous malignant tumor.
Zhang F, Luo W, Min Z, Wu L, Wang Z, Wang Y, Liao W, Liu Y, Chen W, Wen L
BMC cancer 2025 Jul 1;25(1):1071
BMC cancer 2025 Jul 1;25(1):1071
Hsa_circ_0016662 acts as a prognostic biomarker and promotes the progression of hepatocellular carcinoma via autophagy regulation.
Deng G, He Y, Gan B, Liao C, Luo X, Zheng C, Mao L
Journal of translational medicine 2025 Jul 1;23(1):714
Journal of translational medicine 2025 Jul 1;23(1):714
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
Li S, Jiang Z, Wei W, Deng S, Duan T
Journal of translational medicine 2025 Jul 1;23(1):703
Journal of translational medicine 2025 Jul 1;23(1):703
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.
Mu Y, Zhang N, Wei D, Yang G, Yao L, Xu X, Li Y, Xue J, Zhang Z, Chen T
Neural regeneration research 2025 Jul 1;20(7):2116-2128
Neural regeneration research 2025 Jul 1;20(7):2116-2128
Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy.
Hao T, Guo H, Wang C, Jing S, Zhang W, Zeng Y, Hou J, Song Z, Li W
ACS nano 2025 Jul 1;19(25):23315-23333
ACS nano 2025 Jul 1;19(25):23315-23333
Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation.
Ren X, Mei Q, Zhou Y, Jiang L, Liu F, Wang J
BMC research notes 2025 Jul 1;18(1):263
BMC research notes 2025 Jul 1;18(1):263
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Chen Y, Shen J, Yuan M, Li H, Li Y, Zheng S, Han B, Zhang C, Liu S, Sun Q, Wu J
Journal of advanced research 2025 Jan;67:331-348
Journal of advanced research 2025 Jan;67:331-348
Selective Activation of G Protein-Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage.
Liang Y, Fu W, Tang Y, Ye H, Wang Y, Sun C, Xiang Y, Xiong W, Cui M, Chen Y, Wang T, Deng Y
Molecular neurobiology 2025 Jan;62(1):871-884
Molecular neurobiology 2025 Jan;62(1):871-884
Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology.
Han W, Xie L, Ding C, Dai D, Wang N, Ren J, Chen H, Zhu S, Xiao J, Xu H
Molecular neurobiology 2025 Jan;62(1):1031-1046
Molecular neurobiology 2025 Jan;62(1):1031-1046
Protective effect of ginseng extract and total ginsenosides on hematopoietic stem cell damage by inhibiting cell apoptosis and regulating the intestinal microflora.
Liang Z, Gao X, Jing C, Yuan T, Zhang L, Yin Y, Ou J, Li X, Qi W, Zhao D, Su H, Zhang H
International journal of molecular medicine 2025 Jan;55(1)
International journal of molecular medicine 2025 Jan;55(1)
Irisin alters D-galactose-induced apoptosis by increasing caveolin-1 expression in C2C12 myoblasts and skeletal muscle fibroblasts.
Wu Y, Wu Y, Yu J, Zhang Y, Dai X, Chen J, Sun Y, Yang Y, Zhao K, Xiao Q
Molecular and cellular biochemistry 2025 Jan;480(1):577-588
Molecular and cellular biochemistry 2025 Jan;480(1):577-588
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Ji M, Weng S, Li X, Xiao Q, Tong Y, Zhou Y, Luo T, Liu Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Gypenoside XLIX alleviates sepsis-associated encephalopathy by targeting PPAR-α.
Zhao P, Zhang W, Zhou X, Zhao Y, Li A, Sun Y
Experimental neurology 2025 Jan;383:115027
Experimental neurology 2025 Jan;383:115027
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease.
Xie A, Cheng G, Wu J, Li Z, Yu G, Zhu X, Chen T
Biomaterials 2025 Jan;312:122749
Biomaterials 2025 Jan;312:122749
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
Huang Y, Zhang Y, Liu Y, Jin Y, Yang H
The Journal of biological chemistry 2025 Jan;301(1):108111
The Journal of biological chemistry 2025 Jan;301(1):108111
Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells.
Bostancı F, Şengelen A, Aksüt Y, Yıldırım E, Öğütcü İ, Yücel O, Emik S, Gürdağ G, Pekmez M
Pharmaceutical development and technology 2025 Jan;30(1):25-36
Pharmaceutical development and technology 2025 Jan;30(1):25-36
Diagnostic and prognostic potential of FBXO8 expression in kidney renal clear cell carcinoma and its regulation of renal adenocarcinoma cells.
Luo Z, Wu X, Xie J, Tang H, Chen J, Ye D, Dou S, Chen S
Cancer genetics 2025 Jan;290-291:6-15
Cancer genetics 2025 Jan;290-291:6-15
A novel protein encoded by circARHGAP12 attenuates DNA damage and apoptosis by regulating MDC1 in intestinal ischemia/reperfusion injury.
Liu D, Zhao X, Wang Z, Wang G, Chen Z, Ning S, Feng D, Sun X, Sun R, Yao J, Tian X
International journal of biological macromolecules 2025 Jan;286:138374
International journal of biological macromolecules 2025 Jan;286:138374
LINC00942 Alleviates NaAsO(2)-induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p.
Ma M, Zhang J, Li S, Zhang M, Chen W, Li L, Li S
Biological trace element research 2025 Jan;203(1):167-177
Biological trace element research 2025 Jan;203(1):167-177
Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity.
Liu Z, Gao H, Li G, Yu Y, Cui M, Peng H, Guan X, Zhang X, Zhang Z, Shen X, Chen S, Li D, Chen L, Xiao Y, Chen W, Liu L, Wang Q
Environment international 2025 Jan;195:109234
Environment international 2025 Jan;195:109234
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Guo L, Chen W, Yue J, Gao M, Zhang J, Huang Y, Xiong H, Li X, Wang Y, Yuan Y, Chen L, Fei F, Xu R
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Protective role of Yougui Yin in experimental knee osteoarthritis: From the perspective of macrophage polarization.
Wu Z, Xu K, Chen M, Wang S, Ma Y
Prostaglandins & other lipid mediators 2025 Jan;176:106940
Prostaglandins & other lipid mediators 2025 Jan;176:106940
Sini decoction alleviates inflammation injury after myocardial infarction through regulating arachidonic acid metabolism.
Long C, Zhou Q, Xu M, Ding X, Zhang X, Zhang Y, Tang Y, Tan G
Chinese herbal medicines 2025 Jan;17(1):148-155
Chinese herbal medicines 2025 Jan;17(1):148-155
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer.
Yang J, Wang H, Li B, Liu J, Zhang X, Wang Y, Peng J, Gao L, Wang X, Hu S, Zhang W, Hong L
Metabolism: clinical and experimental 2025 Jan;162:156041
Metabolism: clinical and experimental 2025 Jan;162:156041
Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
Han H, Yang M, Wen Z, Mei F, Chen Q, Ma Y, Lai X, Zhang Y, Fang R, Yin T, Sun S, Wang X, Qi J, Lin H, Yang Y
Bioorganic chemistry 2025 Jan;154:107981
Bioorganic chemistry 2025 Jan;154:107981
PINK1 modulates Prdx2 to reduce lipotoxicity-induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction.
Zhang H, Xu T, Mei X, Zhao Q, Yang Q, Zeng X, Ma Z, Zhou H, Zeng Q, Xu D, Ren H
Clinical and translational medicine 2025 Jan;15(1):e70166
Clinical and translational medicine 2025 Jan;15(1):e70166
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Bi T, Zhao Q, Wang T, Huang R, Liu B, Liu X, Wang Y, Sun Q, Yang Y, Liu Z
Advanced healthcare materials 2025 Jan;14(2):e2403473
Advanced healthcare materials 2025 Jan;14(2):e2403473
Cyclovirobuxine D inhibits triple-negative breast cancer via YAP/TAZ suppression and activation of the FOXO3a/PINK1-Parkin pathway-induced mitophagy.
Wang ZQ, Wu ZX, Chen JW, Li HF, Wu HD, Bao JX, Cheng Y, Dai YW, Wang OC, Dai XX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156287
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156287
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Liu W, Hu J, Wang Y, Gan T, Ding Y, Wang X, Xu Q, Xiong J, Xiong N, Lu S, Wang Y, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats.
Zhang T, Zhang T, Yu H, Chi L
Immunity, inflammation and disease 2025 Jan;13(1):e70110
Immunity, inflammation and disease 2025 Jan;13(1):e70110
MFGE8 promotes gastric cancer progression by activating the IL-6/JAK/STAT3 signaling.
Ding LL, Zhang M, Zhang T, Liu H, Liu PF
Cellular signalling 2025 Jan;125:111486
Cellular signalling 2025 Jan;125:111486
HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide.
Cao S, Li Y, Chen L, Lei X, Feng X, Li Y
Poultry science 2025 Jan;104(1):104571
Poultry science 2025 Jan;104(1):104571
Long non-coding RNA LINC01224 plays an oncogenic role in endometrial cancer via miR-4673/TPX2 axis and activating Wnt/β-catenin signaling pathway.
Lv S, Zhang X, Lang F, Wu Y, Zhang C, Qi Q, Jiang J
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2153
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2153
Anti-tumor Effects of Hedyotis diffusa Willd on Cervical Cancer: Inhibition of Proliferation, Migration, and Induction of Apoptosis.
Yang S, Zeng L, Deng C, Tian X, Sun W, Ji C, Zhang Q
Iranian journal of pharmaceutical research : IJPR 2025 Jan-Dec;24(1):e159390
Iranian journal of pharmaceutical research : IJPR 2025 Jan-Dec;24(1):e159390
ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress.
Carter JL, Su Y, Al-Antary ET, Zhao J, Qiao X, Wang G, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Buck SA, Hüttemann M, Allen JE, Prabhu VV, Yang J, Taub JW, Ge Y
Journal of experimental & clinical cancer research : CR 2025 Jan 9;44(1):10
Journal of experimental & clinical cancer research : CR 2025 Jan 9;44(1):10
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
Liu W, Lu J, Li J, Wang L, Chen Y, Wu Y, Zhang Z, Zhang J, Gao F, Jia C, Bao Y, Yang X, Song Z
International journal of molecular sciences 2025 Jan 9;26(2)
International journal of molecular sciences 2025 Jan 9;26(2)
Vitamin A enhances PI3K/Akt signaling and mitigates enterocyte apoptosis in a mouse model of necrotizing enterocolitis.
Su Q, Chen L, Liu D, Xu Y, Feng J, Yu J, Zhang Z, Yu Z
Pediatric surgery international 2025 Jan 8;41(1):61
Pediatric surgery international 2025 Jan 8;41(1):61
CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.
Yang K, Wang Y, Jian Y, Wang B, Du H, Xia Y, Bi J, Guo M, Li Z, Wang N
Cancer cell international 2025 Jan 8;25(1):8
Cancer cell international 2025 Jan 8;25(1):8
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway.
Wang D, Zhao X, Li J, Song Y, Chen W, Cai X, Liu R, Chen Z
Metabolic brain disease 2025 Jan 7;40(1):91
Metabolic brain disease 2025 Jan 7;40(1):91
Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function.
Sun L, Huang J, Dou X, Dong Z, Li Y, Tan S, Yu R, Li C, Zhao W
Animals : an open access journal from MDPI 2025 Jan 7;15(2)
Animals : an open access journal from MDPI 2025 Jan 7;15(2)
hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1.
Wang Y, Liu C, Wang N, Weng D, Zhao Y, Yang H, Wang H, Xu S, Gao J, Lang C, Fan Z, Yu L, He Z
Stem cell research & therapy 2025 Jan 5;16(1):2
Stem cell research & therapy 2025 Jan 5;16(1):2
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Liu H, Guo Z, Zang Z, Jia B, Zhou Y, Zhang H, Fu Q
Journal of ethnopharmacology 2025 Jan 31;340:119273
Journal of ethnopharmacology 2025 Jan 31;340:119273
Taraxasterol extracted from Ixeridium gramineum (Fisch.) Tzvel. Attenuated D-GalN/LPS-induced fulminant hepatitis by modulating the JAK/STAT and TNF signalling pathways.
Wang G, Yin Y, Lv R, Ling X, Cao H, Liu H, Wu J, Gao Y, Zhang K, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119256
Journal of ethnopharmacology 2025 Jan 31;340:119256
Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.
Tian W, Song P, Zang J, Zhao J, Liu Y, Wang C, Fang H, Wang H, Zhao Y, Liu X, Gao Y, Cao L
Journal of ethnopharmacology 2025 Jan 31;340:119169
Journal of ethnopharmacology 2025 Jan 31;340:119169
Osteoking inhibits apoptosis of BMSCs in osteoporotic rats via PI3K/AKT signaling pathway.
Huang G, Yin W, Zhao X, Xu M, Wang P, Li R, Zhou L, Tang W, Jiao J
Journal of ethnopharmacology 2025 Jan 31;340:118961
Journal of ethnopharmacology 2025 Jan 31;340:118961
Revealing the molecular mechanism of baohuoside I for the treatment of breast cancer based on network pharmacology and molecular docking.
Mu J, Li Y, Chen Q, Xiao Y, Hu M, He Z, Zeng J, Ding Y, Song P, He X, Yang X, Zhang X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118918
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118918
Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota.
Li B, Liu M, Du W, Wang S, Xu Z, Zhang X, Zhang Y, Hua S
BMC veterinary research 2025 Jan 29;21(1):39
BMC veterinary research 2025 Jan 29;21(1):39
N(6)-methyladenosine in 28S rRNA promotes oncogenic mRNA translation and tyrosine catabolism.
Chen B, Li L, Huang Y, Ma J, Ji F, Chen Y, Wu L, Peng H
Cell reports 2025 Jan 28;44(1):115139
Cell reports 2025 Jan 28;44(1):115139
Formononetin ameliorates polycystic ovary syndrome through suppressing NLRP3 inflammasome.
Liu Z, Wang RH, Wang KH
Molecular medicine (Cambridge, Mass.) 2025 Jan 27;31(1):27
Molecular medicine (Cambridge, Mass.) 2025 Jan 27;31(1):27
Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.
Liu T, Wang Y, An XZ, Liu J, Wu Y, Xiang Y, Zhang YJ, Huang L, Li JC, Li YZ, Yu J
Scientific reports 2025 Jan 25;15(1):3280
Scientific reports 2025 Jan 25;15(1):3280
Icaritin alleviates motor impairment and osteoporosis in Parkinson's disease mice via the ER-PI3K/Akt pathway.
Lin X, Zhou X, Liu X, Xia L, Cai J, Huang N, Luo Y, Wu W
Scientific reports 2025 Jan 25;15(1):3190
Scientific reports 2025 Jan 25;15(1):3190
Integrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy.
Yang Y, Zheng W, Zhang J, Guo J, Liu Q, Wang H, Xu F, Bao Z
ACS applied bio materials 2025 Jan 20;8(1):676-687
ACS applied bio materials 2025 Jan 20;8(1):676-687
Intermittent Fasting Improves Sevoflurane-Induced Cognitive Dysfunction in Rats Through SIRT1-Mediated Autophagy.
Sun FW, Tian Y
Neurochemical research 2025 Jan 20;50(1):81
Neurochemical research 2025 Jan 20;50(1):81
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy.
Ma L, Yao L, Zhang Z, Hao B
Human cell 2025 Jan 20;38(2):46
Human cell 2025 Jan 20;38(2):46
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Yu Z, Wang X, Hu Y, Wang X, Zhu Z, Xu X, Wang Y, Zhang A
Balkan medical journal 2025 Jan 2;42(1):27-36
Balkan medical journal 2025 Jan 2;42(1):27-36
Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma.
Gao D, Lv Y, Hong F, Wu D, Wang T, Gao G, Lin Z, Yang R, Hu J, He A, Zhang P
Scientific reports 2025 Jan 2;15(1):70
Scientific reports 2025 Jan 2;15(1):70
DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a.
Ma T, Li YM, Ren PY, Wang SQ, Liu XL, Lv WB, Hou WG, Zuo WQ, Lin WQ, Sima J, Geng AQ
Zoological research 2025 Jan 18;46(1):87-102
Zoological research 2025 Jan 18;46(1):87-102
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Huang S, Wang H, Cao J, Pang Q
Scientific reports 2025 Jan 18;15(1):2394
Scientific reports 2025 Jan 18;15(1):2394
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development.
Zhang H, Zhang L, Wu Z
Cell division 2025 Jan 17;20(1):1
Cell division 2025 Jan 17;20(1):1
FHOD3 shows clinical significance in progression of ovarian cancer through regulation of caspase-3 signaling pathway.
Huang Y, Zhang Y, Shen Z, Xu J, Sheng J
Gene 2025 Jan 15;933:148943
Gene 2025 Jan 15;933:148943
Heat Tolerance-Associated circRNA3685 Regulates Apoptosis and Autophagy in Bovine Mammary Epithelial Cells via Sponging bta-miR-138.
Zhang C, Hu L, Wang S, Chen G, Brito LF, Li B, Xu Q, Wang Y
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1656-1671
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1656-1671
Changes in meat quality of Esox Lucius during postmortem storage: Based on the lysosomal-mitochondrial apoptotic pathway.
Li H, Fan X, Guo X, Yan W, Yu X, Deng X, Zhang J
Food chemistry 2025 Jan 15;463(Pt 4):141522
Food chemistry 2025 Jan 15;463(Pt 4):141522
Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer.
Li Z, He T, Xing Z, Zhu J, Wu W, Su A
Experimental cell research 2025 Jan 15;444(2):114373
Experimental cell research 2025 Jan 15;444(2):114373
Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Zhang P, Zhou Z, Yao J, Jiang Y, Lei H, Xie Z, Li J, Zhao X, Zhu L, Wan M, Liu L, Tang W
Ecotoxicology and environmental safety 2025 Jan 15;290:117747
Ecotoxicology and environmental safety 2025 Jan 15;290:117747
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.
Luo S, Li J, Zhou Y, Zhai Z, Li Q, Huang Z, He W, Zhong K, Kong B, Xia Z, Kwok HF, Zhu L
Ecotoxicology and environmental safety 2025 Jan 15;290:117594
Ecotoxicology and environmental safety 2025 Jan 15;290:117594
Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress.
Deng H, Taishi Y, Wang G, Kong Y, Zhang R, Zheng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117566
Ecotoxicology and environmental safety 2025 Jan 15;290:117566
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Zhang RH, Chen T, Xiong QQ, Wang S, Chen GQ, Zhang WL, Yuan HF, Zhao YL, Liu T, Huang Y, Zhou M, Yang CL, Liao SG, Li YJ
European journal of medicinal chemistry 2025 Jan 15;282:117059
European journal of medicinal chemistry 2025 Jan 15;282:117059
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src.
Guo X, Yang L, An X, Hu M, Shen Y, Wang N, Xu Y, Gui D
Chinese medicine 2025 Jan 15;20(1):10
Chinese medicine 2025 Jan 15;20(1):10
Identification of Novel 58-5p and SREBF1 Interaction and Effects on Apoptosis of Ovine Ovarian Granulosa Cell.
Yang R, Wang Y, Yue S, Liu Y, Zhang Y, Duan C
International journal of molecular sciences 2025 Jan 11;26(2)
International journal of molecular sciences 2025 Jan 11;26(2)
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
Teng Y, Zhao H, Xue G, Zhang G, Huang Y, Guo W, Zou K, Zou L
Journal of translational medicine 2025 Jan 11;23(1):44
Journal of translational medicine 2025 Jan 11;23(1):44
Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.
Ren R, Zhou X, Jia T, Wang B, Liu A, Gao M, Song J, Wang L, Jing Y, Yu L, Shen H, Zhang X
Scientific reports 2025 Jan 11;15(1):1747
Scientific reports 2025 Jan 11;15(1):1747
RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.
Zhang N, Yang J, Zhao Y, Li W, Zhao B, Li R, He Z, Gu S
Cell death discovery 2025 Jan 10;11(1):4
Cell death discovery 2025 Jan 10;11(1):4
Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis.
Li C, Pang G, Zhao W, Liu Y, Huang X, Chen W, Zhao X, Liu T, Wang P, Fan X, Gao M, Cong M
Hepatology communications 2025 Jan 1;9(1)
Hepatology communications 2025 Jan 1;9(1)
SMP30 alleviates cerebral ischemia/reperfusion-induced neuronal injury by inhibiting HDAC4/PSD-95 to preserve mitochondrial function.
Chen R, Qian L, Zhang Q, Qin J, Chen X, Xu X
Journal of neuropathology and experimental neurology 2025 Jan 1;84(1):59-73
Journal of neuropathology and experimental neurology 2025 Jan 1;84(1):59-73
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
Zhao B, Tan WL, Yu BB, Fan J, Liu C, Liu J, Liu Z
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Molecular and cellular endocrinology 2025 Jan 1;595:112392
COPS5 regulates osteosarcoma progression by upregulating KHSRP to promote Per2 mRNA decay.
Bu J, Xu X, Luo Y, Liu J, Yao X
Experimental cell research 2025 Jan 1;444(1):114358
Experimental cell research 2025 Jan 1;444(1):114358
Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance.
Qiu T, Zhi Y, Zhang J, Wang N, Yao X, Yang G, Jiang L, Lv L, Sun X
Ecotoxicology and environmental safety 2025 Jan 1;289:117641
Ecotoxicology and environmental safety 2025 Jan 1;289:117641
Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression.
Chen M, Zhang Y, Zhao Y, Cao K, Niu R, Guo D, Sun Z
Ecotoxicology and environmental safety 2025 Jan 1;289:117476
Ecotoxicology and environmental safety 2025 Jan 1;289:117476
Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy.
Shi J, Liang M, Qiu Y, Zhang J, Wang S, Fang H, Jiang Y, Ye X, Luo Y, Huang ZS, Quan YY
Talanta 2025 Jan 1;282:127074
Talanta 2025 Jan 1;282:127074
Oxidative stress and apoptosis of the spinal cord in a rat model of retinoic acid-induced neural tube defects.
Wu P, Shen N, Feng S, Liu W, Wang J, Wang C
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2025 Feb;85(1):e10399
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2025 Feb;85(1):e10399
Omaveloxolone Ameliorates Cognitive Deficits by Inhibiting Apoptosis and Neuroinflammation in APP/PS1 Mice.
Liu Z, Jia J
Molecular neurobiology 2025 Feb;62(2):2191-2202
Molecular neurobiology 2025 Feb;62(2):2191-2202
Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy.
Sun S, Yang S, Cheng Y, Fang T, Qu J, Tian L, Zhang M, Wu S, Sun B, Chen L
International journal of molecular medicine 2025 Feb;55(2)
International journal of molecular medicine 2025 Feb;55(2)
METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway.
Huang R, Feng X, Zhou T, Lu J, Wang Y, Zhang S, Zhang W
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Feb;54(2):91-99
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Feb;54(2):91-99
Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway.
Ma J, Yue S, Liu Y, Gong L, He P, Yang Y, Fu Z, Han D, Hu Q, Liao F, Xu L
Toxicology and applied pharmacology 2025 Feb;495:117213
Toxicology and applied pharmacology 2025 Feb;495:117213
Multi-omics analysis explore the mechanism of deoxynivalenol inhibiting rabbit appetite through microbial-gut-brain axis.
Yuan X, Chen W, Li R, Guo H, Wang C
Ecotoxicology and environmental safety 2025 Feb;291:117849
Ecotoxicology and environmental safety 2025 Feb;291:117849
High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.
Song Y, Wang X, Zhang H, Ma R, Kang Y, Di X, Feng Z, Ni C, Zhao F, Zhuang H, Zhang J
Ecotoxicology and environmental safety 2025 Feb;291:117833
Ecotoxicology and environmental safety 2025 Feb;291:117833
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Xu M, Chen J, Gao L, Cai S, Dong H
Ecotoxicology and environmental safety 2025 Feb;291:117828
Ecotoxicology and environmental safety 2025 Feb;291:117828
Geniposide Protects Against Myocardial Infarction Injury via the Restoration in Gut Microbiota and Gut-Brain Axis.
Chen J, Zhu T, Yang J, Shen M, Wang D, Gu B, Xu J, Zhang M, Hao X, Tang Z, Tong J, Du Y, Zhang B, Li H, Xu M
Journal of cellular and molecular medicine 2025 Feb;29(3):e70406
Journal of cellular and molecular medicine 2025 Feb;29(3):e70406
Selenium yeast alleviates diquat-induced oxidative stress and testicular damage in roosters.
Xiong N, Liu S, Hu W, Liu Y, Ding X, Xu D, Ling Y, Fang M, Liu B, Zheng L, Zheng W, Wu B
Animal reproduction science 2025 Feb;273:107760
Animal reproduction science 2025 Feb;273:107760
oar-miR-411a-5p Promotes Proliferation and Differentiation in Hu Sheep Myoblasts Under Heat Stress by Targeting SMAD2.
Lu J, Liu Y, Li H
Journal of cellular physiology 2025 Feb;240(2):e31515
Journal of cellular physiology 2025 Feb;240(2):e31515
Aβ -induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases.
Zhang W, Ding F, Rong X, Ren Q, Hasegawa T, Liu H, Li M
Aging cell 2025 Feb;24(2):e14374
Aging cell 2025 Feb;24(2):e14374
E3 ubiquitin ligase ITCH-mediated proteasomal degradation of WBP2 sensitizes breast cancer cells to chemotherapy through restraining AMOTL2/c-JUN axis.
Zhu M, Zhong W, Wong S, Luo X, Hong Z, Lin J, Wu J, Zhou Y, Qi Z, Chen S
Biochemical pharmacology 2025 Feb;232:116720
Biochemical pharmacology 2025 Feb;232:116720
Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke.
Zhang K, Wu G, Chen Y, Hu Q, Li Y, Jiang X, Gu C, Zhang N, Zhao F
Nitric oxide : biology and chemistry 2025 Feb;154:115-127
Nitric oxide : biology and chemistry 2025 Feb;154:115-127
N(6)-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Zhang Y, Shen G, Zhang D, Meng T, Lv Z, Chen L, Li J, Li K
Clinical and translational medicine 2025 Feb;15(2):e70228
Clinical and translational medicine 2025 Feb;15(2):e70228
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Deng Z, Guo J, Zhu Z, Qing Q, Wan D, Lei P, Liu Q, Huang B
Toxicology research 2025 Feb;14(1):tfae202
Toxicology research 2025 Feb;14(1):tfae202
Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway.
Gao G, Zhang X, Cui Z, Fan M, Yan Y, Huang Y, Shi Y, Ma H, Wang Z, Su Y, Zhang Z, Xie Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156366
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156366
Insulin-like growth factor-1 promotes the testicular sperm production by improving germ cell survival and proliferation in high-fat diet-treated male mice.
Liu G, Liu D, Zhu M, Zhang M, Li C, Xu X, Pan F
Andrology 2025 Feb;13(2):342-358
Andrology 2025 Feb;13(2):342-358
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors.
Zeng J, Luo Z, Zhao T, Xia C, Liu F, Li N, Qu L, Wang C
Chemical biology & drug design 2025 Feb;105(2):e70067
Chemical biology & drug design 2025 Feb;105(2):e70067
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis.
Xu Y, Meng W, Dai Y, Xu L, Ding N, Zhang J, Zhuang X
Cell death discovery 2025 Feb 8;11(1):54
Cell death discovery 2025 Feb 8;11(1):54
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8(+) T-cell antitumor activity via the non-canonical P53/STING pathway.
Wu J, Liu N, Chen J, Tao Q, Lu C, Li Q, Chen X, Peng C
Journal for immunotherapy of cancer 2025 Feb 6;13(2)
Journal for immunotherapy of cancer 2025 Feb 6;13(2)
Experimental study on the inhibitory effect of Halofuginone on NSCLC.
Han Y, Liu S, Zhu J, Liu P, Meng Z, Li Y, Li S, Fan F, Zhang M, Liu H
European journal of pharmacology 2025 Feb 5;988:177221
European journal of pharmacology 2025 Feb 5;988:177221
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Zeng L, Wang Y, Huang Y, Yang W, Zhou P, Wan Y, Tao K, Li R
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Lin Z, Feng Y, Wang J, Men Z, Ma X
Microbiome 2025 Feb 4;13(1):36
Microbiome 2025 Feb 4;13(1):36
Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma.
Qiu L, Gao Q, Liao Y, Li X, Li C
Journal of translational medicine 2025 Feb 3;23(1):145
Journal of translational medicine 2025 Feb 3;23(1):145
Inhibition of the FEN1-PBX1 axis elicits cellular senescence in breast cancer via the increased intracellular reactive oxygen species levels.
Wu M, Wu B, Huang X, Wang Z, Zhu M, Zhu Y, Yu L, Liu J
Journal of translational medicine 2025 Feb 28;23(1):248
Journal of translational medicine 2025 Feb 28;23(1):248
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.
Chen X, Wang B, Al Mamun A, Du K, Wang S, Hu Q, Chen X, Lu Y, Du A, Wu Y, Shao J, Wang S, Jiang C, Zhou K, Hu S, Xiao J
Journal of nanobiotechnology 2025 Feb 28;23(1):152
Journal of nanobiotechnology 2025 Feb 28;23(1):152
Discovery of Novel Aromatic Urea-Imidazole Salt Derivatives for Cancer Therapy via Targeting ERK1/2.
Wang M, Yang S, Li X, Zheng Y, Bai Y, Luo W, Zhu G, Chang J, Zhu B
Journal of medicinal chemistry 2025 Feb 27;68(4):4101-4132
Journal of medicinal chemistry 2025 Feb 27;68(4):4101-4132
Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer.
Du X, Luo W, Li H, Gu Q, Huang P, Wang C, Li N, Liu F, Xia C
Molecular cancer 2025 Feb 27;24(1):59
Molecular cancer 2025 Feb 27;24(1):59
Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity.
Liu Y, Song J, Guo Y, Li S, Yuan M, Tang J, Wang Y, Li M, Guo Y, Guo L
International journal of pharmaceutics 2025 Feb 25;671:125289
International journal of pharmaceutics 2025 Feb 25;671:125289
Trp31 Residue of Trx-1 Is Essential for Maintaining Antioxidant Activity and Cellular Redox Defense Against Oxidative Stress.
He Z, Yan Y, Guo X, Wang T, Liu X, Ding RB, Fu Y, Bao J, Qi X
Antioxidants (Basel, Switzerland) 2025 Feb 24;14(3)
Antioxidants (Basel, Switzerland) 2025 Feb 24;14(3)
Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury.
Rao Z, Tang Y, Zhu J, Lu Z, Chen Z, Wang J, Bao Y, Mukondiwa AV, Wang C, Wang X, Luo Y, Li X
Nanomaterials (Basel, Switzerland) 2025 Feb 23;15(5)
Nanomaterials (Basel, Switzerland) 2025 Feb 23;15(5)
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
Sheng Q, Yu Q, Lu S, Yang M, Fan X, Su H, Kong Z, Gao Y, Wang R, Lv Z
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
The Natural Antherea pernyi Sericin Protein Suppresses Gastric Cancer Formation by Inhibiting Cell Proliferation and Inducing Cell Apoptosis.
Wei QQ, Xiao Y, Wu Q, Jing C, Dong ZQ, Chen P, Pan MH
International journal of molecular sciences 2025 Feb 22;26(5)
International journal of molecular sciences 2025 Feb 22;26(5)
Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer.
Wang Y, Peng Y, Hao W, He C, Gao X, Liang P, Zhao H, Wang Y, Wang L, Yu Z, Liu Z
iScience 2025 Feb 21;28(2):111505
iScience 2025 Feb 21;28(2):111505
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Zhang R, Zhang Z, Xie L, Yu Z, Gao R, Zhang ZR, Zhang Y, Wei X, Chen Y, Jiao S, Gao Y, Guo JP
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10.
Tong W, Xie X, Shu Z, Nie J, Yang X, Yang F, Liu Z, Liu J
Journal of translational medicine 2025 Feb 21;23(1):220
Journal of translational medicine 2025 Feb 21;23(1):220
Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis.
Li M, Jiao J, Jiang W, Yu T, Wang Y, Wang Z, Wu M
International immunopharmacology 2025 Feb 20;148:114126
International immunopharmacology 2025 Feb 20;148:114126
Mogroside V ameliorates astrocyte inflammation induced by cerebral ischemia through suppressing TLR4/TRADD pathway.
Chen M, Li L, Qin Y, Teng H, Lu C, Mai R, Zhu Z, Mo J, Qi Z
International immunopharmacology 2025 Feb 20;148:114085
International immunopharmacology 2025 Feb 20;148:114085
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
Wu Y, Zhang Z, Ren M, Chen Y, Zhang J, Li J, Gao F, Bao Y, Huang Y, Yang X, Song Z
Cells 2025 Feb 2;14(3)
Cells 2025 Feb 2;14(3)
Efficient Photosensitizer Delivery by Neutrophils for Targeted Photodynamic Therapy of Glioblastoma.
Wen R, Liu Y, Tian X, Xu Y, Chen X
Pharmaceuticals (Basel, Switzerland) 2025 Feb 19;18(2)
Pharmaceuticals (Basel, Switzerland) 2025 Feb 19;18(2)
Tributyl Phosphate Induced Male Reproductive Toxicity in Mice.
Wang J, Cui Y, Wang Y, Li Y, He Y, Luo T
Environmental science & technology 2025 Feb 18;59(6):3000-3012
Environmental science & technology 2025 Feb 18;59(6):3000-3012
Low-intensity pulsed ultrasound promotes proliferation and differentiation of neural stem cells to enhance spinal cord injury recovery.
Liao YH, Tian MH, Zhou WY, He BQ, Tang C, Tang Q, Ye RP, Zhong DJ
Molecular biology reports 2025 Feb 18;52(1):245
Molecular biology reports 2025 Feb 18;52(1):245
Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.
Meng X, Li Y, Meng L, Yang C, Xia C, Wang X, Wang F
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857
PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development.
Zhang X, Wang S, Liang L, Hu F, Zhang X, Cui X, Zhang Z, Wu X
Journal of molecular histology 2025 Feb 17;56(2):91
Journal of molecular histology 2025 Feb 17;56(2):91
Estrogen Promotes Endometrial Cancer Development by Modulating ZNF626, SLK, and RFWD3 Gene Expression and Inducing Immune Inflammatory Changes.
Fan J, Zhang M, Wu H, Ye Z, Wang L
Biomedicines 2025 Feb 17;13(2)
Biomedicines 2025 Feb 17;13(2)
CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury.
Huang H, Jiang NN, Lu GW, Xu F, Sun LL, Zhu J, Dong Z, Zhang ZJ, Liu S
Free radical biology & medicine 2025 Feb 16;228:44-61
Free radical biology & medicine 2025 Feb 16;228:44-61
Intranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R/GRP75/VDAC1 on MAMs.
Liu H, Jiang Y, Cong L, Zhang X, Zhou Y, Pan X, Liu S, Wang R, Cao X
Free radical biology & medicine 2025 Feb 16;228:240-250
Free radical biology & medicine 2025 Feb 16;228:240-250
MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells.
Jing F, Wang Q, Xu Y, Dong J, Huang H, Li Y
Brain research 2025 Feb 15;1849:149349
Brain research 2025 Feb 15;1849:149349
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Fu H, Wu S, Shen H, Luo K, Huang Z, Lu N, Li Y, Lan Q, Xian Y
Heliyon 2025 Feb 15;11(3):e42095
Heliyon 2025 Feb 15;11(3):e42095
A novel 5'tRNA-derived fragment tRF-Tyr inhibits tumor progression by targeting hnRNPD in gastric cancer.
Cui H, Liu Z, Peng L, Liu L, Xie X, Zhang Y, Gao Z, Zhang C, Yu X, Hu Y, Liu J, Shang L, Li L
Cell communication and signaling : CCS 2025 Feb 14;23(1):88
Cell communication and signaling : CCS 2025 Feb 14;23(1):88
Periplaneta americana Extract Protects Glutamate-Induced Nerve Cell Damage by Inhibiting N-Methyl-D-Aspartate Receptor Activation.
Zhou Y, Yang X, Hong C, Guan T, Xiao P, Yang Y, Zhang C, He Z
Biology 2025 Feb 13;14(2)
Biology 2025 Feb 13;14(2)
Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Hsu KY, Majeed A, Ho CT, Pan MH
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3494-3506
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3494-3506
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
Wang C, Cheng H, Dong X, Zhan Y, Liu Y, Wu N, Tang R, He H, Cao Y, Yang L, Ren J, Li X, Li P
Journal of nanobiotechnology 2025 Feb 12;23(1):104
Journal of nanobiotechnology 2025 Feb 12;23(1):104
Inhibition Effects and Mechanism Study of rAj-HRP30, a Recombinant Histidine-Rich Peptide from Apostichopus japonicus, on the Viability of Pancreatic Ductal Adenocarcinoma Cells Panc01 and Panc02.
Song Y, Gao S, Jiang J, Zhang Y, Zhang J, Wang X, Lv L, Zhou Z, Wang J
International journal of molecular sciences 2025 Feb 11;26(4)
International journal of molecular sciences 2025 Feb 11;26(4)
Methylase METTL3 regulates oxidative stress-induced osteoblast apoptosis through Wnt/β-catenin signaling pathway.
Yang P, Wang H, Meng L, Kou Y, Bu J, Li M
Journal of molecular histology 2025 Feb 10;56(2):86
Journal of molecular histology 2025 Feb 10;56(2):86
Network pharmacology, molecular docking and biological verification to explore the potential anti-prostate cancer mechanisms of Tripterygium wilfordii Hook. F.
Sang Y, Hu Y, Zhang Y, Chen L, Lu Y, Gao L, Lu Y, Cao X, Zhang Y, Chen G
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119071
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119071
Raddeanin A suppresses intracellular (5)Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma.
Liu X, Xie X, Wang K, Liu X, Gong J, Yang Z, Li J
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119036
Journal of ethnopharmacology 2025 Feb 10;338(Pt 2):119036
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice.
Wu Y, Yang Y, Du C, Peng X, Fan W, Chang B, Shan C
Scientific reports 2025 Feb 10;15(1):4918
Scientific reports 2025 Feb 10;15(1):4918
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
Yang Z, Gao Y, Li D, Zhao L, Du Y
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
RhFGF21 protected PC12 cells against mitochondrial apoptosis triggered by H(2)O(2) via the AKT-mediated ROS signaling pathway.
Lin J, Wu J, Xu Y, Zhao Y, Ye S
Experimental cell research 2025 Feb 1;445(1):114417
Experimental cell research 2025 Feb 1;445(1):114417
Ginsenoside Rg1 Alleviates Hydrogen Peroxide-Induced Autophagy and Apoptosis in Ovarian Granulosa Cells.
Li X, Weng SQ, Li QH, Ji M, Zhou Y, Xiao Q, Luo T, Liu ZX
Cell biochemistry and biophysics 2025 Dec;83(4):4781-4792
Cell biochemistry and biophysics 2025 Dec;83(4):4781-4792
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.
Ma Y, Sun T, Ren K, Ma R, Min T, Wang X, Yuan Y, Xie X, Zhang B, Deng X, Peng Y, Liu Y, Nan Y, Wang W, Zhou Z, Xu G, Li K, Zhu K, Hao N, Dang C, Zhang G, Zhang H
Journal of advanced research 2025 Dec;78:555-571
Journal of advanced research 2025 Dec;78:555-571
MAP6D1 Silencing alleviates high glucose-induced injury of trophoblast cells during gestational diabetes mellitus.
Li X, Zhu Y, Jiang X, Liu S, Hu J, Zhang M, Bai M, Xu X, Yao H
Cytotechnology 2025 Dec;77(6):193
Cytotechnology 2025 Dec;77(6):193
Comparative Evaluation of Biocompatibility between Conventional and Computer-Aided Design/Computer-Aided Manufacturing Dental Polymers Using a Golden Hamster Model.
Wei X, Shangguan H, Wu L, Gao L, Pan Y, Cheng Y, Cheng H, Wang Y
International dental journal 2025 Dec;75(6):103958
International dental journal 2025 Dec;75(6):103958
Harmine derivative H-2-168 induces the death of Echinococcus granulosus by regulating mitochondrial fusion and fission.
Gong Y, Zhao M, Pan M, Zhao Y, Liu J, Wen H, Wang J
Pharmaceutical biology 2025 Dec;63(1):188-200
Pharmaceutical biology 2025 Dec;63(1):188-200
Cancer-associated fibroblast-derived extracellular vesicles regulate lipophagy through PLIN2 to modulate dormancy in salivary gland adenoid cystic carcinoma cells.
Dou Z, Zhang X, Meng K, Li M, Pang X, Wang W, Shi R, Liang X, Tang Y
Experimental & molecular medicine 2025 Dec;57(12):2852-2868
Experimental & molecular medicine 2025 Dec;57(12):2852-2868
Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8(+) T cells by granzyme B and perforin.
Zhang C, Wang Y, Yu Y, Pang Y, Xiao X, Hao L
Annals of medicine 2025 Dec;57(1):2439539
Annals of medicine 2025 Dec;57(1):2439539
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Jia G, Li J, Jiang M, Liu N, Ding N, Jiang X, Zhang G, Tan X, Kang Y, Zhang L, Wang F, Zhang Y
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Arfgef3 knockout ameliorates ischemia reperfusion-induced acute kidney injury via mitochondrial dysfunction alleviation in mice.
Wang L, Yao L, Xie D, Ding W
Renal failure 2025 Dec;47(1):2572359
Renal failure 2025 Dec;47(1):2572359
Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress.
Zhang L, Zhang G, Mao W, Sun S, Tao S, Gao Y, Zhang N, Jiang G, Chen M, Lu X, Chen S
Renal failure 2025 Dec;47(1):2483986
Renal failure 2025 Dec;47(1):2483986
Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.
Chen J, Chen C, Lv C, Feng R, Zhong W, Liu Y, Zhou S, Zhao M
Renal failure 2025 Dec;47(1):2463572
Renal failure 2025 Dec;47(1):2463572
TM4SF1 as a Prognostic Biomarker and Therapeutic Target in Cervical Cancer.
Deng JX, Zhang LY, Ouyang ZQ, Guo T, Shen FJ, Zheng HY
Current medical science 2025 Dec;45(6):1367-1381
Current medical science 2025 Dec;45(6):1367-1381
Design, synthesis, and bioevaluation of pyrazole-containing tubulin polymerisation inhibitors based on conformational constraint strategy.
Sun Z, Wang J, Li F, Huang L, Zheng S, Guan Q, Wang Z, Zhang W
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2545004
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2545004
Stemness reducible effects of glyasperin A against NCCIT teratocarcinomas.
Nguyen TN, Trieu HP, Nguyen TC, Do TP, Le HNH, Tran LNK, Chu HH, Nguyen TN, Pham VC, Nguyen TKO, Do TT
Naunyn-Schmiedeberg's archives of pharmacology 2025 Dec;398(12):17225-17237
Naunyn-Schmiedeberg's archives of pharmacology 2025 Dec;398(12):17225-17237
Kirenol Ameliorates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation.
Pan L, Fu M, Tang XL, Ling Y, Su Y, Ge J
Cardiovascular drugs and therapy 2025 Dec;39(6):1259-1273
Cardiovascular drugs and therapy 2025 Dec;39(6):1259-1273
Study on the Stereoselective Pharmacokinetics and Neuroprotective Effects on HT22 Cells of Pinocembrin Enantiomers.
Chen L, Chen X, Huang D, Liu Y, Zhang Y, Li H
Chirality 2025 Dec;37(12):e70063
Chirality 2025 Dec;37(12):e70063
Enhanced oral nanomedicine utilizing biomineralized oncolytic virus for synergistic gastrointestinal cancer therapy.
Hu Z, Sun Y, Yu S, Zheng F, Yan Z, Lu N, Ye L, Yuan S, Zhu Y, Deng J, Wang J, Bai Y
Materials today. Bio 2025 Dec;35:102583
Materials today. Bio 2025 Dec;35:102583
Bovine tubulin cofactor D (TBCD) disrupts tubulin dimers and inhibits tumor growth via the TNF-α signaling pathways-mediated ROS production.
Wang H, Guo J, Yang J, Wu X, Wu F, Wu H, Zhan Y, Zhang H
International journal of biological macromolecules 2025 Dec;334(Pt 1):148987
International journal of biological macromolecules 2025 Dec;334(Pt 1):148987
CD44 and αV-integrins dual-targeting bimetallic nanozymes for lung adenocarcinoma therapy via NIR-enhanced ferroptosis/apoptosis.
He J, Li T, Pan X, Deng Z, Huang J, Mo X, Shen X, Qin X, Yang X, Gao M, Yang J
Biomaterials 2025 Dec;323:123407
Biomaterials 2025 Dec;323:123407
Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice.
Ni Y, Jiang X, Wang S, Pu T, Yan T, Yu A, Liu Q
Molecular medicine reports 2025 Dec;32(6)
Molecular medicine reports 2025 Dec;32(6)
Effect of hesperidin on nanocopper induced PANoptosis in chicken kidney through RIPK1/ZBP1 pathway.
Li H, Zhu H, Zhao L, Wu H, Li S, Tang Z, Liao J, Guo J
Veterinary journal (London, England : 1997) 2025 Dec;314:106466
Veterinary journal (London, England : 1997) 2025 Dec;314:106466
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.
Chen Y, Qiang G, Jin L, Sun Y, Zhang G, Hu F, Feng J, Wei F, Zeng S, Xue L, Zeng H, Ma S
Redox report : communications in free radical research 2025 Dec;30(1):2588086
Redox report : communications in free radical research 2025 Dec;30(1):2588086
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
Yang K, Zhu G, Peng T, Cheng Y, Guo X
Redox report : communications in free radical research 2025 Dec;30(1):2550412
Redox report : communications in free radical research 2025 Dec;30(1):2550412
ASIC1a Promotes nucleus pulposus derived stem cells apoptosis through modulation of SIRT3-dependent mitochondrial redox homeostasis in intervertebral disc degeneration.
Zhang ZG, Kang L, Zhou LP, Wang YX, Jia CY, Zhao CH, Zhang B, Wang JQ, Zhang HQ, Zhang RJ, Shen CL
Redox report : communications in free radical research 2025 Dec;30(1):2504120
Redox report : communications in free radical research 2025 Dec;30(1):2504120
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Yao H, Wu R, Du D, Ai F, Yang F, Li Y, Qi S
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Therapeutic Effects of Phyllanthus urinaria L on Cisplatin-Induced Acute Kidney Injury: Anti-Inflammatory, Anti-Apoptotic, and Anti-Oxidative Action.
Guo Q, Li P, Chen M, Yu Y, Shen L, Long C, Liu X, Wei G, Zhang D
Pediatric discovery 2025 Dec;3(4):e70000
Pediatric discovery 2025 Dec;3(4):e70000
Polydatin's neuroprotective mechanism in optic nerve injury: targeting mitochondrial function and glial cell activation.
Hu B, Wang X, Wang X, Zhou S, Yan Y, Yang J, Ma B, Kang Q, Zhang Z, Wang R
Experimental eye research 2025 Dec;261:110685
Experimental eye research 2025 Dec;261:110685
Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury.
Long Z, Zhang J, Feng J, He T
Experimental eye research 2025 Dec;261:110649
Experimental eye research 2025 Dec;261:110649
Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis.
Wu S, Ma X, Zhang X, Du K, Shi C, Almaamari AA, Han B, Su S, Liu Y
Cancer biology & therapy 2025 Dec;26(1):2445220
Cancer biology & therapy 2025 Dec;26(1):2445220
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.
Tan SM, Luo L, He YF, Li W, Wan XX
Cancer biology & therapy 2025 Dec;26(1):2442556
Cancer biology & therapy 2025 Dec;26(1):2442556
Macrophage extracellular traps impair intestinal barrier function in DSS-induced colitis in mice by inducing intestinal epithelial cell apoptosis.
Zhou Z, Miao X, Shen Y, Wang P, Shi R, Fan H, Yang Y, Guo M, Wu J
Biochemical pharmacology 2025 Dec;242(Pt 3):117406
Biochemical pharmacology 2025 Dec;242(Pt 3):117406
Juglone targets MMP-1 to inhibit gastric cancer progression.
Zhou F, Xie Y, Li X, Peng P
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Molecular insights into α-Lactalbumin-Chlorogenic acid interaction: Peptide design and anti-inflammatory mechanisms.
Zheng S, Han C, Zhang T, Zeng X, Bao W, Pan D, Tu M, Wu Z
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 2):117365
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 2):117365
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway.
Zhu C, Zhang M, Yang W, Gao A, Yu X, Su X, Chen R, Guo M
Epigenetics 2025 Dec;20(1):2512764
Epigenetics 2025 Dec;20(1):2512764
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2-mediated pathway.
Yuan J, Chen Y, Wu S, Shi H, Dong Y, Han Y, Cui W
Journal of cell communication and signaling 2025 Dec;19(4):e70032
Journal of cell communication and signaling 2025 Dec;19(4):e70032
Acyl-CoA dehydrogenase long chain acts as a tumor-suppressive factor in lung adenocarcinoma progression.
Wei T, Fu G, Zhao J, Cao F, Guo D
Cell adhesion & migration 2025 Dec;19(1):2495676
Cell adhesion & migration 2025 Dec;19(1):2495676
Appropriate doses of ionizing radiation facilitate the proliferation and anti-tumor effects of γδ T cells through ERK and p38MAPK pathways in vitro.
Wang LL, Yang Y, Feng YB, Zhao HQ, Hong Q, Chen FX, Chen L, Sun LQ, Lü XT, Sun F, Feng H, Chen K, Liu ZH, Guo LL, Zhou ZH
Molecular immunology 2025 Dec;188:80-88
Molecular immunology 2025 Dec;188:80-88
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice.
Liu Y, Wang Z, Zhang Y, Zhao T, Zhang Q, Huang W, Lu B
Gut microbes 2025 Dec;17(1):2537753
Gut microbes 2025 Dec;17(1):2537753
Fusobacterium nucleatum exacerbates colitis via STAT3 activation induced by Acetyl-CoA accumulation.
Xiang Z, Li X, Wang X, Deng B, He H, Xu M, Wu X, Tan C, Liu Y, Yu B, Zhang J, Dong W
Gut microbes 2025 Dec;17(1):2489070
Gut microbes 2025 Dec;17(1):2489070
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Zhang M, Xiang Y, Li C, Xu C, Chen G, Long R, Chen C, Liu Y, Ye F
Bioorganic chemistry 2025 Dec;167:109186
Bioorganic chemistry 2025 Dec;167:109186
Design, synthesis, and evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as anti-HCC agents targeting Nur77.
Hu S, Li X, Yu M, Zhang H, Wang X, Qi C, Huang S, Xu Z, Hu H, Chen S, Fang M, Zeng J
Bioorganic chemistry 2025 Dec;167:109113
Bioorganic chemistry 2025 Dec;167:109113
YTHDC2 promotes sepsis-induced cardiomyopathy by activating apoptosis and NF-κB pathway.
Wang W, Zhang TN, Wang ZM, Yang N, Liu CF
Virulence 2025 Dec;16(1):2597565
Virulence 2025 Dec;16(1):2597565
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction.
Cheng J, Chen S, Geng M, Wei X, Meng S, Gong L, Chen K, Wang Z, Liu Y, Li X, Li A, Li X, Dai L
Advanced healthcare materials 2025 Dec;14(32):e2501507
Advanced healthcare materials 2025 Dec;14(32):e2501507
Fibroblast-secreted ADAMTSL2 promotes cardiac repair after myocardial infarction by activating LRP6/β-catenin signaling.
Wang W, He Y, Liang D, Zhou L, Yang T, Gu L, Du C, Wang S, Wang H, Wang L, Wang Q
Cellular signalling 2025 Dec;136:112144
Cellular signalling 2025 Dec;136:112144
YAP regulates the hypertrophy and apoptosis of antler chondrocytes through maintaining calcium homeostasis and mitochondrial function.
Li BY, Yang ZQ, Xing YF, Zhang QL, Wang CH, Yue ZP, Guo B
Cellular signalling 2025 Dec;136:112137
Cellular signalling 2025 Dec;136:112137
Puerarin alleviates liver injury induced by heat-stress through regulating oxidative stress and apoptosis in broilers.
Xu G, Ma F, Li Y, Miao J, Zhang X, Xiong Y, He S
Journal of thermal biology 2025 Dec;134:104317
Journal of thermal biology 2025 Dec;134:104317
MICU1 attenuates neuronal apoptosis after subarachnoid hemorrhage by inhibiting mitochondrial calcium overload and damage.
Wang J, Cui Y, Ding PF, Zhang JT, Liu XZ, Gao S, Chen XX, Peng Z, Li XJ, Wu LY, Gao YY, Hang CH, Li W
Cell calcium 2025 Dec;132:103080
Cell calcium 2025 Dec;132:103080
Skullcapflavone II Inhibits SLC1A4-Mediated L-Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer.
Zhao J, Ma YB, Xia RH, Jiang ZC, Zhou Y, Wang YN, Yang MY, Dai JJ, Zhu T, Pan LB, Yuan L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e17225
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e17225
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
Zhang Y, Tang D, Yang C, Lin C, Yuan Y, He M, Chen Y, Mao Z, Ying Y, Ma X, Kong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.
Wu H, Guo Z, Hu P, Du J, Wang P, Ma J, Zhao B, Wei J, Li Z
Food & function 2025 Dec 8;16(24):9593-9608
Food & function 2025 Dec 8;16(24):9593-9608
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Zhang Z, Zhang J, Li L, Zong L
Molecular neurobiology 2025 Dec 5;63(1):256
Molecular neurobiology 2025 Dec 5;63(1):256
Neuroprotective peptide OL-FS13 attenuates cardiac apoptosis and myocardial infarction injury through Nrf2/HO-1 pathway.
Wang H, Zhou K, Chen X, Tong Y, Jiang Q, She Q, Xiao J
Clinical and experimental hypertension (New York, N.Y. : 1993) 2025 Dec 31;47(1):2556422
Clinical and experimental hypertension (New York, N.Y. : 1993) 2025 Dec 31;47(1):2556422
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux.
Li M, Wang X, Hong J, Guan X, Chen Y, Zhou H, Wang X, Liang B, Gao X, Wu Y, Song D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71369
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71369
Albiflorin enhances the antitumor effects of propofol in hepatocellular carcinoma cells by inhibiting the Wnt/β-catenin signaling activation.
Ji T, Ye L, Xu C, Ma C, Yin G
Translational cancer research 2025 Dec 31;14(12):8875-8888
Translational cancer research 2025 Dec 31;14(12):8875-8888
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
Xiufang L, Zhongqing W, Huidan W, Ye Z, Xu H, Wei C, Haicui W, Fang L
Journal of ovarian research 2025 Dec 30;19(1):37
Journal of ovarian research 2025 Dec 30;19(1):37
Regulation of Melatonin on AQP4 Expression in Brain of SD Newborn Rats with Bilirubin Encephalopathy and Protection Mechanism.
Xue K, Cheng X, Qian W, Mistry H, Fan P, Hu J, Chen C, Zhang L, Vazirinasab P, Huang J, Lu W, Xu J, Zhu S, Qiu G, Ran J, Gan S
Molecular neurobiology 2025 Dec 3;63(1):239
Molecular neurobiology 2025 Dec 3;63(1):239
The Role of Chaf1b in Maintaining Glioma Stem Cell Stemness and Regulating Microglial Polarization.
He YL, Niu L, Wang C, Liao ZP, Liu K, Gao S, Du AC, Liu WG, Jia J, Zhang YB, Yin H, Yuan GQ, Pan YW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Dec 3;45(49)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Dec 3;45(49)
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.
Xie T, Fan X, Yu T, Zhu Q, Zhang Q, Li N, Wang T, Qian Y, Deng K, Xin H, Li Y, Huang X
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):7
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):7
EXOSC3 knockdown induces G1/S phase arrest to suppress hepatocellular carcinoma cell proliferation.
Chen YM, Huo YX, Wei WS, Liu YX, Wang SH, Jiang L, Rong-He, Zhang HL, Jiang LH
Scientific reports 2025 Dec 29;15(1):44684
Scientific reports 2025 Dec 29;15(1):44684
Apigenin Alleviates Zearalenone-Induced Oxidative Stress and Apoptosis in Swine Testis Cells Through the Wnt Signaling Pathway.
Guo C, Zhang Y, Wang Y, Sun Y, Ning H, Gao J, Guo F, Ji P, Zhang L, Liu G, Wang B
Antioxidants (Basel, Switzerland) 2025 Dec 29;15(1)
Antioxidants (Basel, Switzerland) 2025 Dec 29;15(1)
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN
World journal of stem cells 2025 Dec 26;17(12):112207
World journal of stem cells 2025 Dec 26;17(12):112207
Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway.
Zhang L, Liu Y, Liu R, Wang W, Li R
Scientific reports 2025 Dec 26;16(1):3723
Scientific reports 2025 Dec 26;16(1):3723
Alkaloids isolated from Scutellaria Barbata D. Don trigger apoptosis and inhibit migration by modulating the p38-p53 pathway in ovarian cancer.
Gao B, Sui X, Choe H, Yang Y, Liu Y, Xia L, Li P, Chen Y, Huo Y, Zhao Z, Ding K, Ma J, Zhao D, Zhang L
Journal of ovarian research 2025 Dec 24;18(1):301
Journal of ovarian research 2025 Dec 24;18(1):301
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
Wang HG, Lu MX, Sheng ML, Lou YB, Xiao YC, Guo A, Yu ZH
Scientific reports 2025 Dec 24;15(1):44516
Scientific reports 2025 Dec 24;15(1):44516
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
Li J, Meng F, Qian X, Chen S
Scientific reports 2025 Dec 23;16(1):2568
Scientific reports 2025 Dec 23;16(1):2568
[Dietary secoisolariciresinol diglucoside alleviates chronic kidney disease in offspring rats caused by maternal trans-fatty acid exposure by regulating the Bcl-2/Bax/caspase-3 signaling axis].
Ma S, Chen M, Wu T, Zhao W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2658-2666
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Dec 20;45(12):2658-2666
Sodium butyrate attenuates sodium fluoride-induced cardiac injury in rats via modulating oxidative stress, inflammation, and apoptosis.
Meng L, Yan N, Li X, Sun Z, Qin M, Liu S, Duan X, Zhao Y, Zhang Z, Li Q, Shao B, Ren F, Wang Z
Scientific reports 2025 Dec 2;16(1):1369
Scientific reports 2025 Dec 2;16(1):1369
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
Long noncoding RNA BMPR1B-DT promotes anoikis and reduces proliferation in ovarian cancer.
Li Y, Chen X, Xu Y, Huang S, Zhou C, Tang Z, Liu Y, Chen J, Chen H, Yang Y, He S
BMC cancer 2025 Dec 18;26(1):118
BMC cancer 2025 Dec 18;26(1):118
ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancer.
Fu X, Zhu Y, Lu X, Gao X, Xin L, Ren Y, Liu X, Ge L, Hao J, Yao Z, Shi L, Yang J
Cell death & disease 2025 Dec 18;17(1):119
Cell death & disease 2025 Dec 18;17(1):119
A Scorpion Peptide Exerts Selective Anti-Leukemia Effects Through Disrupting Cell Membranes and Triggering Bax/Bcl-2-Related Apoptosis Pathway.
Dong X, Yi S, Yang Y, Wang Y, Wang L, Huang J, Zeng Y, Liu Z
Biomolecules 2025 Dec 18;15(12)
Biomolecules 2025 Dec 18;15(12)
CCL8 suppresses ovarian cancer progression via M1 macrophage polarization and NF-κB-mediated apoptosis.
Fang J, Zhao X, Wang J, Yang Y, Xiao Y
Scientific reports 2025 Dec 17;16(1):2960
Scientific reports 2025 Dec 17;16(1):2960
Transcription factor EGR2 drives cataract formation through IGFBP3-mediated oxidative injury in lens epithelial cells.
Li W, Zou Y, Zheng W, Zhang J, Cen C, Li R, Cheng H, Hou S, Wan W, Liang L, Kang J, Zheng S, Hu K
Free radical biology & medicine 2025 Dec 16;241:773-788
Free radical biology & medicine 2025 Dec 16;241:773-788
Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy.
Zhu L, Huang M, He L, Rong Z
Free radical biology & medicine 2025 Dec 16;241:150-160
Free radical biology & medicine 2025 Dec 16;241:150-160
Interleukin-38 Ameliorates Atherosclerosis by Inhibiting Macrophage M1-like Polarization and Apoptosis.
Li Z, Li X, Shen R, Wang Y, Yu J, Pan C, Cai Y, Dong Q, Yu K, Zeng Q
Biomolecules 2025 Dec 16;15(12)
Biomolecules 2025 Dec 16;15(12)
Loss of the miR-221/222 Cluster Promotes the Pathogenesis of Osteoarthritis in Inflamed Mouse Chondrocytes and Osteoarthritis Models.
Liu X, Feng F, Jin Y, Ma C, Zhu Q, You Y, Gao M, Li X, Niu X, Wang J
Inflammation 2025 Dec 15;49(1):2
Inflammation 2025 Dec 15;49(1):2
Resveratrol Derivatives with a Urea Backbone Exert Anticancer Effects against Liver Cancer via Apoptosis Induction and Metastasis Inhibition.
Hua W, Cheng Y, Li F, Li Y, Lu Z, Li L, Wang D, Liu J
Journal of agricultural and food chemistry 2025 Dec 10;73(49):31429-31443
Journal of agricultural and food chemistry 2025 Dec 10;73(49):31429-31443
Exosomal miR-223-3p from mesenchymal stem cells targets FBXW7 to inhibit intervertebral disc degeneration: mechanism insights.
Chen R, Cao K, Gong Y, Zhu Y, Pan W, Zhou Q
Journal of orthopaedic surgery and research 2025 Dec 10;21(1)
Journal of orthopaedic surgery and research 2025 Dec 10;21(1)
Astragaloside IV improves cognitive impairment in diabetes by inhibiting calpain-1/NLRP3 mediated microglial activation.
Wang X, Jiang H, Wang H, Zhao C, Ba X
International immunopharmacology 2025 Dec 10;167:115682
International immunopharmacology 2025 Dec 10;167:115682
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Hao J, Zheng J, Liu C, Lu J, Tan M, Li J, Mao J, Yu Y, Wang H, Zhang Y, Shen H
International immunopharmacology 2025 Dec 10;167:115594
International immunopharmacology 2025 Dec 10;167:115594
Liproxstatin-1 Protects SH-SY5Y Cells by Inhibiting H(2)O(2)-Induced Excessive Mitophagy and Apoptosis.
Yan T, Ding F, Fang Z, Zhao Y
International journal of molecular sciences 2025 Dec 1;26(23)
International journal of molecular sciences 2025 Dec 1;26(23)
HIC2 suppresses glioblastoma progression via transcriptional repression of SEMA3A and inhibition of TGF-β signaling.
Zhang L, Yang J, Ke X, Huang N, Zhou D, Cai H
Free radical biology & medicine 2025 Dec 1;240:674-684
Free radical biology & medicine 2025 Dec 1;240:674-684
Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel.
Zhao C, Zhang P, Yang X, Liu M, Guan Z, Ma B, Duan X, Su C
Free radical biology & medicine 2025 Dec 1;240:222-237
Free radical biology & medicine 2025 Dec 1;240:222-237
Apelin-13/APJ promotes neural stem cells to repair ischemic stroke.
Li S, Yuan S, Yang S, Zhou C, Zhong Y, Huang Z, Meng C, Pei L, Xie Y, Chen X, Wu H, Guo Y, Long H, Wang T
Tissue & cell 2025 Aug;95:102872
Tissue & cell 2025 Aug;95:102872
The Synergic Inhibition of Wilforlide A With Cisplatin in Lung Cancer Is Mediated Through Caspase-3 and NFκB Signaling.
Peng Z, Xiao X, Lu X, Cao D, Fang H, Yang Z, He D
IUBMB life 2025 Aug;77(8):e70043
IUBMB life 2025 Aug;77(8):e70043
Mechanism of lncRNA WARS2-IT1 promoting angiogenesis of glioma through miR-299-3P/VEGFA axis and activating PI3K/AKT signaling pathway.
Hu M, Gu W, Huai Y, Wang C, Mei J
Cytotechnology 2025 Aug;77(4):157
Cytotechnology 2025 Aug;77(4):157
Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury.
Chen S, Yao H, Lou Y, Wang H, Xie B, Wu J, Qi X, Wang Y, Wu P, Zhang R, Liu Z, Cheng Y
Journal of advanced research 2025 Aug;74:571-587
Journal of advanced research 2025 Aug;74:571-587
cPDS Promotes Cell Apoptosis by Reducing the Translational Efficiency of BIRC3 mRNA in HCC.
Liu Y, Liu Q, Huang T, Zhang S, Zhou Z, Gu C, Lu C
Digestive diseases and sciences 2025 Aug;70(8):2706-2718
Digestive diseases and sciences 2025 Aug;70(8):2706-2718
GPR30 Inhibits Neuronal Apoptosis After Subarachnoid Hemorrhage by Activating the Wnt/β-Catenin Pathway in a m6A-dependent Manner.
Peng J, He J, Hu X, Xia Y
Molecular neurobiology 2025 Aug;62(8):9638-9650
Molecular neurobiology 2025 Aug;62(8):9638-9650
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Chen H, Duan Z, Jia Q, Zhang X, Xu D, Zheng L, Qi Z, Yang Y, Yang L, Wu C
Molecular neurobiology 2025 Aug;62(8):10834-10855
Molecular neurobiology 2025 Aug;62(8):10834-10855
5-Methoxytryptophan improves cerebrovascular injury induced by chronic kidney disease through NF-κB pathway.
Zhou X, Sun Y, Yang G
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):774-788
In vitro cellular & developmental biology. Animal 2025 Aug;61(7):774-788
Cadmium treatment induces oxidative damage and apoptosis in vitro skeletal muscle cells.
Wenhong L, Yang J, Zhao Y, Zhang N, Zhao B, Rongxian L, Shiyan G, Zuoshun H
Toxicology 2025 Aug;515:154139
Toxicology 2025 Aug;515:154139
USP39 Depletion Plays Repressive Roles in Laryngeal Squamous Cell Carcinoma Development.
Xie W, Zhang L, Hu X, Zhong Y, Li Z
Cell biology international 2025 Aug;49(8):1003-1014
Cell biology international 2025 Aug;49(8):1003-1014
Andrographolide Attenuates Myocardial Ischemia-Reperfusion Injury in Mice by Up-Regulating PPAR-α.
Zhang S, Ye Y, Li Q, Zhao J, Song R, Huang C, Lu X, Huang C, Yin L, You Q
Inflammation 2025 Aug;48(4):2341-2354
Inflammation 2025 Aug;48(4):2341-2354
Inhibition of FKBP5 Alleviates Inflammation and Intestinal Barrier Dysfunction in Sepsis.
Li J, Apizi A, Song T, Kamilijiang P, Yu X, Chai R, Yu Z
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2025 Aug;45(8):290-299
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2025 Aug;45(8):290-299
P5CS deacetylation mediated by SIRT2 facilitates tumor growth by enhancing mitochondrial respiration in hepatocellular carcinoma.
Geng X, Li M, Zhang L, Cai Y, Chen X, Mu X, Wang J, Liu B
Oncogene 2025 Aug;44(31):2746-2761
Oncogene 2025 Aug;44(31):2746-2761
Investigation of the Protective Effect of Red-Light-Intervened Dendrobium officinale on Rats With Gastric Injury Based on Serum Metabolomics.
Luo H, Dong X, Chen L, Xie F, Xu L, Zhang M, Zhu H, Teng J, Dai Z, Yu X
Biomedical chromatography : BMC 2025 Aug;39(8):e70135
Biomedical chromatography : BMC 2025 Aug;39(8):e70135
Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression.
Chen H, Yang Q, Li M, Ren M, Liu S, An G, Ren Y, Liu P, Du L, Sun X, Jin X
Materials today. Bio 2025 Aug;33:102052
Materials today. Bio 2025 Aug;33:102052
Dissolvable microneedle-assisted transdermal administration of diacerein nanoparticles achieved satisfactory therapeutic effects in tendon-bone insertion repair by reducing oxidative stress and inflammation.
Sun J, Chen QZ, Hong AZ, Ju F, Wang HL, Zhang B, Liu W, Sun YC, Tan J, Yang QQ, Zhou YL
Materials today. Bio 2025 Aug;33:101999
Materials today. Bio 2025 Aug;33:101999
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
Lu Y, Wei S, Wang S, Zhang J, Xu Y, Huang C, Pan W, Wang Z
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein.
Zhu L, Yao Z, Liu Y, Shao S, Zhou W, Ding J, Mao B, Shao C, Cui F
International journal of biological macromolecules 2025 Aug;319(Pt 3):145408
International journal of biological macromolecules 2025 Aug;319(Pt 3):145408
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
He H, Huang C, Huang H, Lan N, Liu S, Luo Y, Zheng L, Liu G, Qin Z, Zhao J
Biomaterials 2025 Aug;319:123210
Biomaterials 2025 Aug;319:123210
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Yasheng M, Ji Y, He Y, Yi Q, Zhang H, Shan W, Wang K, Zhang J, Li Y, Meng F, Zhang M, Mo JQ, Wei S, Guan MX
The Journal of biological chemistry 2025 Aug;301(8):110464
The Journal of biological chemistry 2025 Aug;301(8):110464
Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF-κB/COX-2 Signalling Pathways.
Tang H, Dai Q, Zhao Z, Ge W, Li D, Chang Z, Pi P, Li J, Sun Z
Journal of cellular and molecular medicine 2025 Aug;29(15):e70778
Journal of cellular and molecular medicine 2025 Aug;29(15):e70778
TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
Long SJ, Zheng QY, Xu F, Li GQ, Chen J, Chen WJ, Xu JM, Gao XL, Liang SJ, Xu GL
Journal of cellular and molecular medicine 2025 Aug;29(15):e70774
Journal of cellular and molecular medicine 2025 Aug;29(15):e70774
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
Zhang L, Gao A, Peng K
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons.
Luo D, Sun B, Wang W, Zhang A
Biological trace element research 2025 Aug;203(8):4224-4239
Biological trace element research 2025 Aug;203(8):4224-4239
l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids.
Liu A, Wang B, Wang M, Tang R, Xu W, Xiao W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Aug;202:115497
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Aug;202:115497
Methyl alcohol extract of marine green alga Enteromorpha linza (Linnaeus) J. Agardh. induces reactive oxygen species-dependent growth arrest and apoptosis in human hepatocellular carcinoma Hep3B cells.
Choi EO, Kim GY, Hwang HJ, Choi YH
Nutrition research and practice 2025 Aug;19(4):497-510
Nutrition research and practice 2025 Aug;19(4):497-510
ARHGAP11A is a potential prognostic biomarker and therapeutic target for pancreatic adenocarcinoma.
Shu QA, Huang XD, Wu J, Liang XR, Wang YL, Yu JM, Wang ZW, Liu N, Wang JH, Xie N
The international journal of biochemistry & cell biology 2025 Aug;185:106804
The international journal of biochemistry & cell biology 2025 Aug;185:106804
Dehydroabietic acid protects against cerebral ischaemia-reperfusion injury by modulating microglia-mediated neuroinflammation via targeting PKCδ.
Li L, Tang H, She L, Lin Z, Yu Q, Zeng Y, Chen L, Chen F, Liang G, Zhao X, Cho N, Wang Y
British journal of pharmacology 2025 Aug;182(16):3818-3837
British journal of pharmacology 2025 Aug;182(16):3818-3837
Mechanism of sulforaphane in treatment of pancreatic cancer cell based on network pharmacology and in vitro experiments.
Ren Z, Feng J, Yang M, Feng D, Wang X, Liu W
Bioorganic chemistry 2025 Aug;163:108754
Bioorganic chemistry 2025 Aug;163:108754
Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis.
Lee W, Song G, Bae H
Bioorganic chemistry 2025 Aug;163:108636
Bioorganic chemistry 2025 Aug;163:108636
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging.
Jiang P, Song R, Hu Y, He X, Zhang Z, Wei X, Wang Z, Guo DA, Chen H
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4285-4299
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4285-4299
Guggulsterone suppresses osteosarcoma progression by inhibiting glycolysis through MAPK signaling pathway.
Wang Q, Yuan X, Li H, Li J, Wu Z, Zhang W, Fang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156949
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156949
Diminution of HSP75 disrupts intestinal epithelial barrier by inciting mPTP opening in ulcerative colitis.
Liang H, Bai X, Zhu R, Song H, Miao Y, Wen Y, Niu J, Zhang F
Cellular signalling 2025 Aug;132:111837
Cellular signalling 2025 Aug;132:111837
Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts.
Lu J, Liu Y, Li H
Journal of thermal biology 2025 Aug;132:104223
Journal of thermal biology 2025 Aug;132:104223
CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.
Wang Y, Chang F, Li Z, Duan C, Sun X, Wang S, Wei D, Li W, Qian Y, Cao S, Zhao J, Lei D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e14961
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e14961
Melatonin mitigates arsenic and fluoride-induced cardiotoxicity in chickens by maintaining mitochondrial homeostasis.
Yuan X, Wen B, Hu X, Yang M, Han L, Zhao S, Zhang J, Ma Y
Poultry science 2025 Aug;104(8):105325
Poultry science 2025 Aug;104(8):105325
Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma.
Sun F, Liu J, Gao S, Zhang M, Sun X, Tian Y, Wang S
Scientific reports 2025 Aug 8;15(1):29111
Scientific reports 2025 Aug 8;15(1):29111
Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway.
Zhao R, Ma Y, Li S, Li J
Biomolecules 2025 Aug 6;15(8)
Biomolecules 2025 Aug 6;15(8)
G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.
Cheng L, Li S, Cui Z, Sun X, Gong M, Chen Y, Meng L, Liao Y
Clinical & experimental metastasis 2025 Aug 4;42(5):44
Clinical & experimental metastasis 2025 Aug 4;42(5):44
FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization.
Li Z, Ma J, Guan H, Lai J, Xu F, Cao G
Cell biology and toxicology 2025 Aug 4;41(1):123
Cell biology and toxicology 2025 Aug 4;41(1):123
Mechanistic insights into the anti-tumor effects of neochlorogenic acid in hepatocellular carcinoma: in vitro and in vivo studies.
Xu M, Li Y, Sun W, Guan H, Shi R, Li S
Journal of gastrointestinal oncology 2025 Aug 30;16(4):1699-1710
Journal of gastrointestinal oncology 2025 Aug 30;16(4):1699-1710
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
Ha H, Wang J, Zhang X, Du Y, Xiong W, Li S, Shang P
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice.
Nie J, Mei C, Wei A, Wang Y, Fan C, Huang Y, Jiang M, Che H, Chen T, Tian J, Li Y, Huang X, Zhang X
Communications biology 2025 Aug 29;8(1):1308
Communications biology 2025 Aug 29;8(1):1308
Integrated network pharmacology and metabolomics to explore the mechanism of Kadsura coccinea root in alleviating acetaminophen-induced liver injury.
Wang YS, Liu SQ, Yao YX, Zhang S, Li DH, Li HY, Yu HH, Yuan HW, Wang W, Li B, Yang YP
Journal of ethnopharmacology 2025 Aug 29;352:120278
Journal of ethnopharmacology 2025 Aug 29;352:120278
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
Qian H, Bai C, Jia X, Yang Y, Tian X, Wang X
Journal of ethnopharmacology 2025 Aug 29;352:120200
Journal of ethnopharmacology 2025 Aug 29;352:120200
HIF-1α protects cigarette-induced airway epithelial cell apoptosis in COPD by activating REDD1.
Hua J, Liu L, He B, Hu W, Wu Y, Han Y, Zhang J
International immunopharmacology 2025 Aug 28;161:115062
International immunopharmacology 2025 Aug 28;161:115062
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Xie X, Tong W, Xie Y, Jiang H, Jiang A, Huang J, Liu Z, Yu J
Cell death & disease 2025 Aug 28;16(1):655
Cell death & disease 2025 Aug 28;16(1):655
Pacific Oyster-Derived Alcohol Dehydrogenase Activating Peptide Leu-Gln-Pro-Pro-Arg Ameliorates Alcoholic Liver Disease by Enhancing Alcohol Metabolism and Suppressing Mitochondrial-Mediated Apoptosis.
Chen Y, Zhang X, Gao J, Cao W, Qin X, Lin H, Chen Z, Zheng H, Zhu G, Zheng Z
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21422-21431
Journal of agricultural and food chemistry 2025 Aug 27;73(34):21422-21431
TGF-β-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation.
Jia J
Current issues in molecular biology 2025 Aug 27;47(9)
Current issues in molecular biology 2025 Aug 27;47(9)
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
Zhu S, Zhang X, Liu W, Zhou Z, Xiong S, Chen X, Peng C
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.
Gong MQ, Hu YY, Zhang YQ, Wang XD
BMC pregnancy and childbirth 2025 Aug 27;25(1):891
BMC pregnancy and childbirth 2025 Aug 27;25(1):891
PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models.
Xu H, Sun J, Zhao Y, Zhou Y, Wang K, Liu X, Yang J, Wu P, Wang S, Kastelic JP, Qu W, Zhang L, Gu X
Chemico-biological interactions 2025 Aug 25;417:111558
Chemico-biological interactions 2025 Aug 25;417:111558
SIRT3 Acetylation Regulates Mitophagy to Alleviate Deoxynivalenol-Induced Apoptosis in Porcine Alveolar Macrophages Cells.
Fan P, Deng H, Wang Y, Ren Z, Deng J
International journal of molecular sciences 2025 Aug 25;26(17)
International journal of molecular sciences 2025 Aug 25;26(17)
Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy.
Chen Y, Feng X, Li Z, Wang X, Xiong W, Liu J, Wang G, Xu W, Jin R, Zhang L, Qian Z
Journal of translational medicine 2025 Aug 19;23(1):938
Journal of translational medicine 2025 Aug 19;23(1):938
Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications.
Lu WM, Yan J, Liu ZJ, Wu Y, Cui QR, Feng J, Chen Y, Zhu GZ, Peng T, Zhou J, Lu GD
Parasites & vectors 2025 Aug 19;18(1):353
Parasites & vectors 2025 Aug 19;18(1):353
Oxypalmatine promotes apoptosis and protective autophagy in lung cancer cells via the PI3K/AKT pathway.
Qiao G, Huang Z, Zhou Y, Shi J
Cancer cell international 2025 Aug 18;25(1):307
Cancer cell international 2025 Aug 18;25(1):307
Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment.
Gang Q, Lun Y, Zhang X, Uzokov J, Jiang H, He Y, Shen S, Wang S, Erhart P, Böckler D, Li Y, Han Y, Zhang J
Communications biology 2025 Aug 15;8(1):1230
Communications biology 2025 Aug 15;8(1):1230
Mitochondrial-dependent apoptosis and STAT3 activation induced by oxidative stress in pemphigus vulgaris.
Liang JP, Xu JM, Ou YJ, Xu YJ, Wu SM, Chen JB
Scientific reports 2025 Aug 14;15(1):29900
Scientific reports 2025 Aug 14;15(1):29900
PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Su T, Si Y
Tissue & cell 2025 Apr;93:102739
Tissue & cell 2025 Apr;93:102739
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Wang C, Liu Z, Xie X, Li Y, Sun L
Tissue & cell 2025 Apr;93:102646
Tissue & cell 2025 Apr;93:102646
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Chen L, Zeng L, Pan S, Zu L, Pan H, Fan L
Cytotechnology 2025 Apr;77(2):76
Cytotechnology 2025 Apr;77(2):76
Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy.
Zheng J, Zhang A, Du Q, Li C, Zhao Z, Li L, Zhang Z, Qin X, Li Y, Wang KN, Yu N
Journal of colloid and interface science 2025 Apr;683(Pt 1):420-431
Journal of colloid and interface science 2025 Apr;683(Pt 1):420-431
Mechanisms of Differential Sensitivity to Ethanol-Induced Apoptosis in Mouse Spinal Cord at Different Developmental Stages-Akt/GSK Signaling and BAX.
Sun S, Wang Z, Xu X, Ding X, Xu J, Nan X, Li X, Xu J, Ren Z
Molecular neurobiology 2025 Apr;62(4):4301-4318
Molecular neurobiology 2025 Apr;62(4):4301-4318
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
Li S, Wang L, Wen Y, Han J, Hou J, Hou Z, Xie J, Li H, Li X, Yang Y, Feng R
Virology 2025 Apr;605:110451
Virology 2025 Apr;605:110451
EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib.
Attiogbe MKI, Huang TT, Zhao HY, Wang HY, Cao L, Yan PP, Zhang SQ, Cao YX
Toxicology and applied pharmacology 2025 Apr;497:117280
Toxicology and applied pharmacology 2025 Apr;497:117280
Yishen Tongluo formula ameliorates kidney injury modulating inflammation and apoptosis in streptozotocin-induced diabetic kidney disease mice.
Jiayao Y, Suhui WU, Yufan M, Hanbing LI, Genlin LI, Jiangyan XU
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Apr;45(2):254-265
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Apr;45(2):254-265
Low molecular weight heparins promote migration and invasion of trophoblast cells through regulating the PI3K/AKT signaling pathway.
Zhou Q, Zhao Y, Fu X
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4645-4656
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4645-4656
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy.
Sun W, Wang R, Gong K, Wang L, Li F, Deng J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4571-4582
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4571-4582
Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma.
Wang MF, Guo J, Yuan SJ, Li K, Zhang Q, Lei HM, Wu JL, Zhao L, Xu YH, Chen X
Biomaterials 2025 Apr;315:122913
Biomaterials 2025 Apr;315:122913
Oxidized Low-Density Lipoprotein Decreases the Survival of Bone Marrow Stem Cells via Inhibition of Bcl-2 Expression.
Li X, Li Y, Yu H, Men LL, Deng G, Liu Z, Du JL
Tissue engineering. Part A 2025 Apr;31(7-8):325-333
Tissue engineering. Part A 2025 Apr;31(7-8):325-333
Plasma-Derived Exosomal i-tRF-LeuCAA as Biomarker for Glioma Diagnosis and Promoter of Epithelial-Mesenchymal Transition via TPM4 Regulation.
Liu H, Hu W, Zhang L, Li Z, Liu J, Chen L
CNS neuroscience & therapeutics 2025 Apr;31(4):e70356
CNS neuroscience & therapeutics 2025 Apr;31(4):e70356
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Ma YN, Jiang XM, Hu XQ, Wang L, Gao JJ, Liu H, Qi FH, Song PP, Tang W
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury.
Yang L, Liu Y, Tao C, Cao Z, Guo S, Wei Z, Wang Y, Liu T, Chen L, Xiong K, Luo X, Ran J, Han W
Materials today. Bio 2025 Apr;31:101529
Materials today. Bio 2025 Apr;31:101529
Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair.
Wang P, Chen Z, Li P, Al Mamun A, Ning S, Zhang J, Tang C, Sun T, Xiao J, Wei X, Wu F
Materials today. Bio 2025 Apr;31:101518
Materials today. Bio 2025 Apr;31:101518
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.
Zhang X, Ma L, Liu X, Zhou X, Wang A, Lai Y, Zhang J, Li Y, Chen S
Materials today. Bio 2025 Apr;31:101469
Materials today. Bio 2025 Apr;31:101469
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Zhou MY, Liu BQ, Gao X, Zhang SJ, Jiang Y, Yang T, Sun JB, Zhang X, Liao Y
International journal of biological macromolecules 2025 Apr;300:140270
International journal of biological macromolecules 2025 Apr;300:140270
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Wang G, Li Z, Han W, Tian Q, Liu C, Jiang S, Xiang X, Zhao X, Wang L, Liao J, Li M
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia.
Liu N, Sun Y, Liu J, Zhang Y, Yi X, Yan W, Cui X, Guo T, Zhao W, Han S, Ma W, Cao Y, Chen L
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):842-860
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):842-860
Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: in vitro insights and in silico modelling of proapoptotic gene product-compound interactions.
Saini D, Chaudhary PK, Chaudhary JK, Kaur H, Verma GK, Pramanik SD, Roy P, Mirza-Shariff AA, Prasad R
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):805-825
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):805-825
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
Zhang BH, Chen H, Yang R, Jiang Z, Huang S, Chen Z, Liu C, Wang L, Liu XH
The FEBS journal 2025 Apr;292(8):2119-2144
The FEBS journal 2025 Apr;292(8):2119-2144
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein.
Hu F, Tong S, Xu H
The Journal of membrane biology 2025 Apr;258(2):123-133
The Journal of membrane biology 2025 Apr;258(2):123-133
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists.
Lin H, Cui S, Xu X, Chen Q, Ge J, Ai D, Zhu J, Tao Y, Wang L, Ruan L, Ge W
Bioorganic chemistry 2025 Apr;157:108307
Bioorganic chemistry 2025 Apr;157:108307
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Yu H, Chen K, Li X, Liang J, Jin Y, Bao Y, Chen H, Gou Y, Lu K, Wu L, Lin Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Xin-Ji-Er-Kang balances mitochondrial fusion and fission to protect cardiomyocytes in mice with heart failure by regulating the ERα/SIRT3 pathway.
Cai WW, Qin YY, Ge F, Zhou Q, Huang L, Yang PB, Xia J, Li KK, Hou YF, Wu JM, Wang DY, You Y, Lu WJ, Gao S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156420
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156420
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis.
Wang Y, Chen X, Chen Y, Sun Q, Wang H
Archives of physiology and biochemistry 2025 Apr;131(2):188-198
Archives of physiology and biochemistry 2025 Apr;131(2):188-198
HUWE1-Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury.
Yang Y, Wang P, Zhou K, Zhang W, Liu S, Ouyang J, Bai M, Ding G, Huang S, Jia Z, Zhang A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2412250
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2412250
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway.
Tao Z, Li P, Tang Y, Yang W, Li Y, Yang J, Tian J, Zhang Y, Zou Y, Xu B, Zhao X
Neurochemical research 2025 Apr 9;50(2):138
Neurochemical research 2025 Apr 9;50(2):138
MIS18BP1 promotes bladder cancer cell proliferation and growth via inactivating P53 signaling pathway.
Cao W, Tan X, Li X, Wang Y, Zhai Y, Zhang Z, Yuan J, Song W
Medical oncology (Northwood, London, England) 2025 Apr 9;42(5):156
Medical oncology (Northwood, London, England) 2025 Apr 9;42(5):156
Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2.
Zhang L, Fang F, Liu D, Xia G, Feng T, Lv J, Qi J, Li T, Liu H, Xu T, Wu F, Song C, Li W, Wang X, Chang X, Wang H, Wang T, Qian Z
Respiratory research 2025 Apr 9;26(1):131
Respiratory research 2025 Apr 9;26(1):131
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer.
Ren N, Chen H, Huang Y, Jin J, Zhang S, Yan R, Li M, Zheng L, Zou S, Li Y, Tan W, Lin D
Cancer biology & medicine 2025 Apr 8;22(3):266-83
Cancer biology & medicine 2025 Apr 8;22(3):266-83
Targeted Regulation of HSP70 by the ARP2/3 Complex in Mammary Epithelial Cells and Its Impact on Host Cell Apoptosis.
Yang T, Fang B, Chen Y, Bao D, Zhang J, Liu P, Duan Z, He Y, Zhao X, Zhang QW, Dong WT, Zhang Y
Biomolecules 2025 Apr 7;15(4)
Biomolecules 2025 Apr 7;15(4)
SO(2) derivatives impair ovarian function by inhibiting Serpine1/NF-κB pathway-mediated ovarian granulosa cell survival.
Wu S, Zhang X, Lu Y, Ma Y, Qi X, Wang X, Tan J
Journal of hazardous materials 2025 Apr 5;487:137116
Journal of hazardous materials 2025 Apr 5;487:137116
Xifeng Jiannao pill mitigates MPTP-induced neuronal apoptosis by reducing inflammation and oxidative stress via MAPK signaling.
Han X, He G, Wang J, Lou H, Chen L, Zhang L, Liu B, Wu D, Liu X, Wang S, Zhang C, Guo L
Metabolic brain disease 2025 Apr 4;40(4):170
Metabolic brain disease 2025 Apr 4;40(4):170
Zearalenone Depresses Lactation Capacity Through the ROS-Mediated PI3K/AKT Pathway.
Chen H, Qiu D, Miao X, Yang W, He Q, Ren H, Zhang L, Ruan H, Zhang J, Zhang N
Animals : an open access journal from MDPI 2025 Apr 4;15(7)
Animals : an open access journal from MDPI 2025 Apr 4;15(7)
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
Cao C, Xu W, Lei J, Zheng Y, Zhang A, Xu A, Lin F, Zhou M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting.
Wang C, Su Y, Shi J, Feng G
Journal of molecular histology 2025 Apr 28;56(3):146
Journal of molecular histology 2025 Apr 28;56(3):146
UFBP1 Ameliorates Heat Stress-Induced Apoptosis via Mitochondria-Mediated Pathway in Bovine Mammary Epithelial Cells.
Li Y, Yu R, Tan S, Jiang Y, Sun L, Shen M, Zhang C, Chen K, Li C
Animals : an open access journal from MDPI 2025 Apr 27;15(9)
Animals : an open access journal from MDPI 2025 Apr 27;15(9)
Sulforaphane Inhibits LPS-induced Macrophage PANoptosis via TLR4/NFκB Pathway: A Potential Therapeutic Strategy for Acute Lung Injury.
Wang Y, Liu H, Feng Y, Wu S, He J, Cao L
The Tohoku journal of experimental medicine 2025 Apr 26;265(4):239-248
The Tohoku journal of experimental medicine 2025 Apr 26;265(4):239-248
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
Liu Y, Wang Y, Wang X, Zeng W, Zhang Z, Zhang Z, Qi Z
Pharmaceutics 2025 Apr 26;17(5)
Pharmaceutics 2025 Apr 26;17(5)
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
Wu H, Zhang Z, Xue Y, Guo J, Ouyang Z, Cao Z, Guo W, Zhang Q, Wang M, Gu X
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
Neutrophil extracellular traps induced by neoadjuvant chemotherapy of breast cancer promotes vascular endothelial damage.
Kong L, Hu S, Zhao Y, Huang Y, Xiang X, Yu Y, Mao X, Xie K, Zhu X, Xu P
Breast cancer research : BCR 2025 Apr 23;27(1):61
Breast cancer research : BCR 2025 Apr 23;27(1):61
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation.
Chu J, Song J, Fan Z, Zhang R, Wang Q, Yi K, Gong Q, Liu B
Pharmaceuticals (Basel, Switzerland) 2025 Apr 22;18(5)
Pharmaceuticals (Basel, Switzerland) 2025 Apr 22;18(5)
HPV11E6/E7 induces nasal epithelial hyperplasia through JAK2/STAT3 signaling pathway.
Zhang Y, Tian K, Zheng L, Zhu G, Zhao R, Zhou E, Xue X, Huang S, Chen X, Hu B, Yao W
European journal of medical research 2025 Apr 2;30(1):224
European journal of medical research 2025 Apr 2;30(1):224
Lactobacillus murinus ZNL-13 Modulates Intestinal Barrier Damage and Gut Microbiota in Cyclophosphamide-Induced Immunosuppressed Mice.
Dong Y, Zhang L, Qiu D, Yao R, Jia H, Wang H, Zhou L, Zhang J, Zhang N
Foods (Basel, Switzerland) 2025 Apr 19;14(8)
Foods (Basel, Switzerland) 2025 Apr 19;14(8)
SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis.
Guo W, Wang S, Yang Z, Dong Y, Xia Z, Xue W, Zhang C
European journal of medical research 2025 Apr 18;30(1):306
European journal of medical research 2025 Apr 18;30(1):306
Canolol Alleviates Ethanol-Induced Gastric Ulcer by Inhibiting p38 MAPK/NF-κB/NLRP3 Pathway.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9103-9111
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9103-9111
Synthesis of AgInS(2) quantum dots loaded with celastrol for induction of apoptosis and autophagy in hepatocellular carcinoma cells.
Gong Q, Zhu T, Zhang L, Wu H, Miao Y, Hu Y
Discover oncology 2025 Apr 16;16(1):538
Discover oncology 2025 Apr 16;16(1):538
Anethole trithione mitigates LPS/D-Gal-induced acute liver injury by suppressing ROS production and NF-κB activity.
He Z, Tan X, Yuan M, Chen L, Meng Y, Wang Q, Hu J, Qiu Z, Yang Y
International immunopharmacology 2025 Apr 16;152:114371
International immunopharmacology 2025 Apr 16;152:114371
Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity.
Zhou X, Zhu D, Wu D, Li G, Liang H, Zhang W, Wu Y, Xu H, Zhang Z, Tong B, Song Y, Wang K, Feng X, Lei J, Wang H, Zhang X, Ma L, Chen Y, Wei J, Ou Z, Peng S, Wu X, Tan L, Wang B, Yang C
Cell reports. Medicine 2025 Apr 15;6(4):102079
Cell reports. Medicine 2025 Apr 15;6(4):102079
RAF1 promotes anlotinib resistance in non-small cell lung cancer by inhibiting apoptosis.
Wu S, Hu C, Hu P, He W, Hui K, Jiang X
Journal of cancer research and clinical oncology 2025 Apr 14;151(4):138
Journal of cancer research and clinical oncology 2025 Apr 14;151(4):138
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.
Li Y, Zhai F, Kong L, Zhu J, Li H, Jin X
Discover oncology 2025 Apr 12;16(1):520
Discover oncology 2025 Apr 12;16(1):520
Effect of 1-DNJ on Oxidative Stress-Induced Apoptosis in Porcine Ovarian GCs Through Modulation of the PERK-ATF4/MFN2 Signaling Pathway.
Xing W, Li M, Wang B, Huo L, Tian W, Ge F, Shen M, Sun L, Liu J, Yu S
Antioxidants (Basel, Switzerland) 2025 Apr 11;14(4)
Antioxidants (Basel, Switzerland) 2025 Apr 11;14(4)
Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress.
Fu H, Wang Y, Huang B, Liang Z, Li Y, Cao Z, Wu J, Zhao Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:892-909
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:892-909
Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway.
Jin K, Shen C, Yu W, Lin J, Zhu J, Tao H, Liu B
Chemico-biological interactions 2025 Apr 1;410:111420
Chemico-biological interactions 2025 Apr 1;410:111420
Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.
Liu Y, Zhou R, Guo Y, Hu B, Xie L, An Y, Wen J, Liu Z, Zhou M, Kuang W, Xiao Y, Wang M, Xie G, Zhou H, Lu R, Peng H, Huang Y
Cell metabolism 2025 Apr 1;37(4):824-841.e8
Cell metabolism 2025 Apr 1;37(4):824-841.e8
Lack of ALCAT1 enhances the protective effects of aerobic exercise on kidney in HFpEF mice.
Zhang L, Feng L, Zhao Y, Geng Y, Liu R, Ma Y, Bo W, Xi Y, Tian Z
Life sciences 2025 Apr 1;366-367:123500
Life sciences 2025 Apr 1;366-367:123500
Idebenone improves mitochondrial respiratory activity and attenuates oxidative damage via the SIRT3-SOD2 pathway in a prion disease cell model.
Sun Z, Wen P, Yang D, Li J, Li Z, Zhao M, Wang D, Gou F, Wang J, Fan Q, Dai Y, Ji Y, Li X, Tu Y, Ma T, Wang X, Zhao D, Yang L
Life sciences 2025 Apr 1;366-367:123481
Life sciences 2025 Apr 1;366-367:123481
The novel miR_146-Tfdp2 axis antagonizes METH induced neuron apoptosis and cell cycle abnormalities in tree shrew.
Zhang S, Wang C, Liu J, Liu L, Miao L, Wang H, Tian Y, Cheng H, Li J, Zeng X
Neuropharmacology 2025 Apr 1;267:110300
Neuropharmacology 2025 Apr 1;267:110300
A Hybrid Manganese Nanoparticle Simultaneously Eliminates Cancer Stem Cells and Activates STING Pathway to Potentiate Cancer Immunotherapy.
Wu Y, Diao P, Peng Y, Yang Y, Wang Y, Lv P, Li J, Wang D, Cai T, Cheng J
ACS nano 2025 Apr 1;19(12):12237-12252
ACS nano 2025 Apr 1;19(12):12237-12252
REGγ deficiency ameliorates hepatic ischemia and reperfusion injury in a mitochondrial p66shc dependent manner in mice.
Guo L, Yang Q, Zhu J, Li J
Translational gastroenterology and hepatology 2024;9:62
Translational gastroenterology and hepatology 2024;9:62
Role of cyclophilin A in aggravation of myocardial ischemia reperfusion injury via regulation of apoptosis mediated by thioredoxin-interacting protein.
Mahesutihan M, Yan J, Midilibieke H, Yu L, Dawulin R, Yang WX, Wulasihan M
Clinical hemorheology and microcirculation 2024;87(4):491-513
Clinical hemorheology and microcirculation 2024;87(4):491-513
Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis.
Zhu P, Wu Z, Yang Z, Tang T, Liao Y, Zhao W, Huang Y, Chen T, Li J, Nong C, Wu Z, Hu G, Liu Y, Chen Y
Research (Washington, D.C.) 2024;7:0344
Research (Washington, D.C.) 2024;7:0344
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Cheng C, Li J, Zhang D, Xu D, Yu W
International heart journal 2024;65(6):1137-1143
International heart journal 2024;65(6):1137-1143
Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.
Ma L, Zhang T, Wang R, Li C, Yu J, Wang G, Cai H, Li T, Zhang Y, Li Y, Xie P
International heart journal 2024;65(4):730-737
International heart journal 2024;65(4):730-737
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Gao XF, Ji BY, Zhang JJ, Wang Z, Jiang S, Hu JN, Gong XJ, Zhang JT, Tsopmejio ISN, Li W
The American journal of Chinese medicine 2024;52(5):1427-1449
The American journal of Chinese medicine 2024;52(5):1427-1449
Metformin alleviates lung ischemia-reperfusion injury in a rat lung transplantation model.
Yu H, Wang J, Liu M, Hu C, Sun J, Xu B, Lu S, Huang D, Pang Q, Hu C
Experimental lung research 2024;50(1):15-24
Experimental lung research 2024;50(1):15-24
Lobetyolin Suppresses the Proliferation of Hepatocellular Carcinoma through Activating DUSP1-ERK1/2 Signaling Pathway.
Hu J, Wang D, Wang F, Lin P
Biological & pharmaceutical bulletin 2024;47(10):1751-1758
Biological & pharmaceutical bulletin 2024;47(10):1751-1758
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Gong D, Dong Z, Chen X, Chen H, Lin H
Acta cirurgica brasileira 2024;39:e396124
Acta cirurgica brasileira 2024;39:e396124
Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation.
Chen L, Yin Y, Liu C, Liu J, Zheng M, Tang Y, Yang Q, Liu J, Chen F, Liu L, Liu G
Iranian journal of basic medical sciences 2024;27(3):343-351
Iranian journal of basic medical sciences 2024;27(3):343-351
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Xiang C, Lu Y, Hao R, Wei Y, Hu Y, Yu G
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Iranian journal of basic medical sciences 2024;27(12):1547-1557
CAPN5 attenuates cigarette smoke extract-induced apoptosis and inflammation in BEAS-2B cells.
Li H, Ma Y, Li T, Zeng Z, Luo L, Liu X, Li Y, Chen Y
Tobacco induced diseases 2024;22
Tobacco induced diseases 2024;22
Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes.
Hao N, Yong H, Zhang F, Liu C, Qiu Y, Shi Y, Li C, Wang F
International journal of medical sciences 2024;21(2):306-318
International journal of medical sciences 2024;21(2):306-318
Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis.
Wang J, Jia N, Zhu K, Xu K, Yan M, Lan M, Liu J, Liu B, Shen T, He Q
Analytical cellular pathology (Amsterdam) 2024;2024:8753898
Analytical cellular pathology (Amsterdam) 2024;2024:8753898
Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis.
Zhang J, Guo J, Gu B, Wang F, Li Y, Shang L, Jiang W, Ma J, Wu W
Analytical cellular pathology (Amsterdam) 2024;2024:7752299
Analytical cellular pathology (Amsterdam) 2024;2024:7752299
Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.
Sun J, Yao C, Luo W, Ge X, Zheng W, Sun C, Zhang Y
Journal of tissue engineering and regenerative medicine 2024;2024:3870988
Journal of tissue engineering and regenerative medicine 2024;2024:3870988
The Effect Mechanism of N6-adenosine Methylation (m6A) in Melatonin Regulated LPS-induced Colon Inflammation.
Li Y, Ma B, Wang Z, Chen Y, Dong Y
International journal of biological sciences 2024;20(7):2491-2506
International journal of biological sciences 2024;20(7):2491-2506
Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
Liu X, Zhang Q, Wang P, Peng X, An Y, Chen J, Huang J, Qin S, He H, Hao M, Tian J, Yi L, Lei M, Luo P, Wang J, Zhang X
International journal of biological sciences 2024;20(12):4601-4617
International journal of biological sciences 2024;20(12):4601-4617
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296
International journal of biological sciences 2024;20(11):4277-4296
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Li Z, Jia B, Guo Z, Zhang K, Zhao D, Li Z, Fu Q
PloS one 2024;19(7):e0306926
PloS one 2024;19(7):e0306926
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
Lv M, Li X, Yin Z, Yang H, Zhou B
PloS one 2024;19(4):e0294227
PloS one 2024;19(4):e0294227
MiR-204-5p regulates SIRT1 to promote the endoplasmic reticulum stress-induced apoptosis of inner ear cells in C57BL/6 mice with hearing loss.
Hu Y, Luo X, Chen H, Ke J, Feng M, Yuan W
PloS one 2024;19(11):e0309892
PloS one 2024;19(11):e0309892
Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease.
Hao W, Lin F, Kong W, Shi H, Dong H, Guan Z, Liu G, Wang X, Wang L, Liu M, Jiang Y
Open medicine (Warsaw, Poland) 2024;19(1):20241070
Open medicine (Warsaw, Poland) 2024;19(1):20241070
ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis.
Wang H, Zhao W, Wang D, Chen J
Open medicine (Warsaw, Poland) 2024;19(1):20240941
Open medicine (Warsaw, Poland) 2024;19(1):20240941
Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.
Yang Y, Yang S, Zhang B, Wang J, Meng D, Cui L, Zhang L
International journal of nanomedicine 2024;19:8949-8970
International journal of nanomedicine 2024;19:8949-8970
Mitochondrial Targeted Cerium Oxide Nanoclusters for Radiation Protection and Promoting Hematopoiesis.
Yang L, Ran H, Yin Y, Liu J, Lu B, Ran X, Luo S, Wang W, Yang Z, Li R
International journal of nanomedicine 2024;19:6463-6483
International journal of nanomedicine 2024;19:6463-6483
Synergistic Effect of Layered Double Hydroxides Nanodosage Form to Induce Apoptosis and Ferroptosis in Breast Cancer.
Pang S, Geng C, Fan Z, Hou M, Mao H, Tao S, Wang J, Wu Y, Wei K, Li Y, Yan L, Yang Q, Chen C, Wang W
International journal of nanomedicine 2024;19:4199-4215
International journal of nanomedicine 2024;19:4199-4215
Anti-Cancer Potency of Copper-Doped Carbon Quantum Dots Against Breast Cancer Progression.
Wang M, Lan S, Zhang W, Jin Q, Du H, Sun X, He L, Meng X, Su L, Liu G
International journal of nanomedicine 2024;19:1985-2004
International journal of nanomedicine 2024;19:1985-2004
Effective-Component Compatibility of Bufei Yishen Formula III Suppresses Mitochondrial Oxidative Damage in COPD: Via Pkm2/Nrf2 Pathway.
Liu Y, Zhang L, Zhao J, Lu R, Shao X, Xu K, Li J, Tian Y
International journal of chronic obstructive pulmonary disease 2024;19:1905-1920
International journal of chronic obstructive pulmonary disease 2024;19:1905-1920
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Wang D, Wang J, Yin Z, Gong K, Zhang S, Zha Z, Duan Y
International journal of nanomedicine 2024;19:10839-10856
International journal of nanomedicine 2024;19:10839-10856
Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice.
Luo Y, Sun S, Zhang Y, Liu S, Zeng H, Li JE, Huang J, Fang L, Yang S, Yu P, Liu J
Drug design, development and therapy 2024;18:5685-5700
Drug design, development and therapy 2024;18:5685-5700
Combining Network Pharmacology and Transcriptomics to Investigate the Mechanisms of Yujiang Paidu Decoction in the Treatment of Chronic Rhinosinusitis with Nasal Polyps.
Li Y, Yin Y, Xiong J, Zhang Z, Li L, Zhang B, Zhang F, Mao D
Drug design, development and therapy 2024;18:3791-3809
Drug design, development and therapy 2024;18:3791-3809
Short-Term Preconditioning with Insulin and Glucose Efficiently Protected the Kidney Against Ischemia-Reperfusion Injury via the P-AKT-Bax-Caspase-3 Signaling Pathway in Mice.
Sun L, Bing H, Zhang C, Lin L, Lian H, Chu Q, Jin X
Drug design, development and therapy 2024;18:2461-2474
Drug design, development and therapy 2024;18:2461-2474
Nepetoidin B Alleviates Liver Ischemia/Reperfusion Injury via Regulating MKP5 and JNK/P38 Pathway.
Yu Q, Mei C, Cui M, He Q, Liu X, Du X
Drug design, development and therapy 2024;18:2301-2315
Drug design, development and therapy 2024;18:2301-2315
α-Synuclein-mediated mitochondrial translocation of cofilin-1 leads to oxidative stress and cell apoptosis in PD.
Yan M, Zhang Q, Chen Y, Zhu C, Wang D, Tan J, He B, Li Q, Deng X, Wan Y
Frontiers in neuroscience 2024;18:1420507
Frontiers in neuroscience 2024;18:1420507
Propofol and Dexmedetomidine Ameliorate Endotoxemia-Associated Encephalopathy via Inhibiting Ferroptosis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Drug design, development and therapy 2024;18:1349-1368
Drug design, development and therapy 2024;18:1349-1368
Tuina Promotes Repair of Chronic Cervical Muscle Injury by Regulating Satellite Cell Proliferation and Differentiation and Inhibiting Myocyte Apoptosis.
Zhang J, Qu S, Huang Y, Zhang X, Tong X, Fang Y, Rao T, Liu K, Lin J, Lin Y, Zeng C, Zhang G, Jing X, Liao J, Kan Y
Journal of pain research 2024;17:3419-3429
Journal of pain research 2024;17:3419-3429
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.
Guo N, Xia Y, He N, Cheng H, Zhang L, Liu J
Journal of inflammation research 2024;17:10255-10272
Journal of inflammation research 2024;17:10255-10272
Ligustrazine alleviates spinal cord injury-induced neuropathic pain by inhibiting the TLR4/NF-κB signaling pathway.
Jin H, He Y, Liu T, Yang T, Sun X, Chen Y, Shen F
American journal of translational research 2024;16(8):3557-3571
American journal of translational research 2024;16(8):3557-3571
Integrating network pharmacology with experimental validation to investigate the mechanism of Wuwei Zishen formula in improving perimenopausal syndrome.
Fu X, Wang H, Gai M, Dai Y, Chang J, Zhang H
American journal of translational research 2024;16(6):2190-2211
American journal of translational research 2024;16(6):2190-2211
PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.
Zhong J, Huang K, Xie S, Tan A, Peng J, Nie D, Ma L, Li Y
Journal of Cancer 2024;15(9):2538-2548
Journal of Cancer 2024;15(9):2538-2548
KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer.
Lu Y, Zhao X, Yuan M, Zhao M, Liu K, Zhang M, Qiu X, Yu X, Liu X, Wei D, Xie J, Cheng Z
Journal of Cancer 2024;15(9):2475-2485
Journal of Cancer 2024;15(9):2475-2485
CENPW knockdown inhibits progression of bladder cancer through inducing cell cycle arrest and apoptosis.
Zhang P, Yang Q, Chen X, Chen X, Wang Q, Chen K, An Y, Jiang K, Sun F
Journal of Cancer 2024;15(3):858-870
Journal of Cancer 2024;15(3):858-870
TXNDC12 inhibits pancreatic tumor cells ferroptosis by regulating GSH/GGT7 and promotes its growth and metastasis.
Xu X, Hei Y, Wang B, Tian S, Chen X, Zhang J, Wang F
Journal of Cancer 2024;15(12):3913-3929
Journal of Cancer 2024;15(12):3913-3929
CSF2 Impairs Nrf2 Signaling through the Akt/Mtor Pathway in the Development of Bladder Cancer.
Yu X, Li S, Ke S, Ye C, Wang Q, Wang H, Wang L
Journal of Cancer 2024;15(11):3242-3253
Journal of Cancer 2024;15(11):3242-3253
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity.
Zhang W, Teng H, Zhao T, Eglitis RI, Wang X, Yu Z, Qu S, Wang H, Zhao Y, Fan B, Liu S, Zhao Y
Frontiers in pharmacology 2024;15:1518810
Frontiers in pharmacology 2024;15:1518810
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Qin Y, Gao Y, Wu D, Liu QQ, Su C, Liu G, Yang L, Zhao MG, Yao JY
Frontiers in pharmacology 2024;15:1509482
Frontiers in pharmacology 2024;15:1509482
CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway.
Qu H, Fang Y, Zhang F, Liu W, Xia S, Duan W, Zou K
Frontiers in pharmacology 2024;15:1502165
Frontiers in pharmacology 2024;15:1502165
Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.
Xu AL, Shen Z, Wang SH, Luan HY, Xu Y, Kang ZC, Liao ZQ, Liu J, Duan XL, Bian WH, Sun H, Xie X
Frontiers in pharmacology 2024;15:1496380
Frontiers in pharmacology 2024;15:1496380
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota.
Shen Y, Gao Y, Yang G, Zhao Z, Zhao Y, Gao L, Li S
Frontiers in pharmacology 2024;15:1496346
Frontiers in pharmacology 2024;15:1496346
Molecular targets and mechanisms of Sijunzi decoction in the treatment of Parkinson's disease: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation.
Jiang Y, Wu W, Xie L, Zhou Y, Yang K, Wu D, Xu W, Fang R, Ge J
Frontiers in pharmacology 2024;15:1487474
Frontiers in pharmacology 2024;15:1487474
Japanese encephalitis virus infection induces mitochondrial-mediated apoptosis through the proapoptotic protein BAX.
Yang K, Li X, Yang S, Zheng Y, Cao S, Yan Q, Huang X, Wen Y, Zhao Q, Du S, Lang Y, Zhao S, Wu R
Frontiers in microbiology 2024;15:1485667
Frontiers in microbiology 2024;15:1485667
Targeting autophagy: polydatin's role in inducing cell death in AML.
Fu P, Luo Q, Wang C, Chen L, Dong C, Yang K, Wu G
Frontiers in pharmacology 2024;15:1470217
Frontiers in pharmacology 2024;15:1470217
The NEDD4/FLRT2 axis regulates NSCLC cell stemness.
Yang Y, Yan F, Gao Z, Li H, Wen S, Li Q, Li J, Huang N, Zhao W
Frontiers in pharmacology 2024;15:1459978
Frontiers in pharmacology 2024;15:1459978
Comprehensive analysis of lactylation-related gene sets and mitochondrial functions in gastric adenocarcinoma: implications for prognosis and therapeutic strategies.
Yin X, Xing W, Yi N, Zhou Y, Chen Y, Jiang Z, Ma C, Xia C
Frontiers in immunology 2024;15:1451725
Frontiers in immunology 2024;15:1451725
Overexpression of endothelial S1pr2 promotes blood-brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models.
Cheng H, Men Y, An Y, Yu J, Zhang G, Li J, Wang X, Sun G, Wu Y
Frontiers in pharmacology 2024;15:1448570
Frontiers in pharmacology 2024;15:1448570
YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes.
Feng ZW, Yang CF, Xiao HF, Yuan F, Chen F, Zhang B, Zhang J, Tan M, Guo MG
Frontiers in immunology 2024;15:1440398
Frontiers in immunology 2024;15:1440398
Host factor RBMX2 promotes epithelial cell apoptosis by downregulating APAF-1's Retention Intron after Mycobacterium bovis infection.
Wang C, Jiang Y, Yang Z, Xu H, Khalid AK, Iftakhar T, Peng Y, Lu L, Zhang L, Bermudez L, Guo A, Chen Y
Frontiers in immunology 2024;15:1431207
Frontiers in immunology 2024;15:1431207
Screening mitochondria-related biomarkers in skin and plasma of atopic dermatitis patients by bioinformatics analysis and machine learning.
Yu H, Lin J, Yuan J, Sun X, Wang C, Bai B
Frontiers in immunology 2024;15:1367602
Frontiers in immunology 2024;15:1367602
The therapeutic mechanism of Compound Lurong Jiangu Capsule for the treatment of cadmium-induced osteoporosis: network pharmacology and experimental verification.
Zhou YS, Huang J, Cao WX, Yu AX, Li P, Liang JL, Leng XY, Jin J, Yu P, Liu J
Frontiers in endocrinology 2024;15:1331488
Frontiers in endocrinology 2024;15:1331488
YY1-induced lncRNA00511 promotes melanoma progression via the miR-150-5p/ADAM19 axis.
Chen YN, Fu XR, Guo H, Fu XY, Shi KS, Gao T, Yu HQ
American journal of cancer research 2024;14(2):809-831
American journal of cancer research 2024;14(2):809-831
Identification of key programmed cell death genes for predicting prognosis and treatment sensitivity in colorectal cancer.
Ma JY, Wang YX, Zhao ZY, Xiong ZY, Zhang ZL, Cai J, Guo JW
Frontiers in oncology 2024;14:1483987
Frontiers in oncology 2024;14:1483987
Neoadjuvant immunotherapy plus chemotherapy for squamous cell carcinoma of the paranasal sinus: a case report.
Sun Y, Yang G, Sun R, Cao F
Frontiers in oncology 2024;14:1462993
Frontiers in oncology 2024;14:1462993
Hyperosmotic cold shock mouse melanoma cells encapsulated with doxorubicin for targeted treatment of melanoma.
Kong W, Wang C, Wang H, Liu H, Mu J, Jiang J, Zhang C
Frontiers in oncology 2024;14:1403719
Frontiers in oncology 2024;14:1403719
Decreased expression of LncRNA CRYM-AS1 promotes apoptosis through the Hippo-YAP1 signaling pathway leading to diabetic erectile dysfunction.
Zhang ZB, Chen Y, Huang ZS, Du ZJ, Wang W, Tang BW, Yuan SS, Chen DL, Zhu SG, Chen J
American journal of clinical and experimental urology 2024;12(5):226-239
American journal of clinical and experimental urology 2024;12(5):226-239
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C
Burns & trauma 2024;12:tkad062
Burns & trauma 2024;12:tkad062
Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
Du J, Liu W, Song Y, Zhang Y, Dong C, Xiong S, Huang Z, Wang T, Ding J, He Q, Yu Z, Ma X
Burns & trauma 2024;12:tkad057
Burns & trauma 2024;12:tkad057
Hsa_circ_0001615 downregulation inhibits esophageal cancer development through miR-142-5p/β-catenin.
Dai Y, Xu Q, Xia M, Chen C, Xiong X, Yang X, Wang W
PeerJ 2024;12:e17089
PeerJ 2024;12:e17089
The long noncoding RNA MIR4435-2HG enhances the migration, promotion, and glycolysis of nonsmall cell lung cancer cells by targeting the miR-371a-5p/SOX2/PI3K/Akt axis.
Yang J, Su Y, Wang Y, Gao K, Li C, Li M
SAGE open medicine 2024;12:20503121241289290
SAGE open medicine 2024;12:20503121241289290
New molecular mechanisms of quercetin in improving recurrent spontaneous abortion based on in-depth network pharmacology and molecular docking.
Wang D, Li X, Li Y, Wang R, Wang C, Li Y
Frontiers in chemistry 2024;12:1407667
Frontiers in chemistry 2024;12:1407667
Listeria monocytogenes: possible mechanism of infection of goat uterus and its effects on uterine autophagy and cell apoptosis.
Hong H, Hu Y, Shi S, Liu B, Zheng W, Bo R, Xu Z, Wu Y, Cao Y
Frontiers in veterinary science 2024;11:1413523
Frontiers in veterinary science 2024;11:1413523
Iguratimod Alleviates Experimental Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.
Zhang Q, Yang XR, Deng Y
Cell biochemistry and biophysics 2024 Sep;82(3):2275-2283
Cell biochemistry and biophysics 2024 Sep;82(3):2275-2283
HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway.
Deng B, He X, Wang Z, Kang J, Zhang G, Li L, Kang X
In vitro cellular & developmental biology. Animal 2024 Sep;60(8):868-878
In vitro cellular & developmental biology. Animal 2024 Sep;60(8):868-878
ACAT1 suppresses clear cell renal cell carcinoma progression by AMPK mediated fatty acid metabolism.
Zheng M, Zhang S, Zhou J, Lin M, Liao Y
Translational oncology 2024 Sep;47:102043
Translational oncology 2024 Sep;47:102043
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress.
Wang K, Wang Y, Wan H, Wang J, Hu L, Huang S, Sheng M, Wu J, Han X, Yu Y, Chen P, Chen F
Genes & genomics 2024 Sep;46(9):1013-1022
Genes & genomics 2024 Sep;46(9):1013-1022
Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury.
Lin J, Sun Y, Xia B, Wang Y, Xie C, Wang J, Hu J, Zhu L
Neuroscience bulletin 2024 Sep;40(9):1230-1244
Neuroscience bulletin 2024 Sep;40(9):1230-1244
The protective effects of Axitinib on blood-brain barrier dysfunction and ischemia-reperfusion injury in acute ischemic stroke.
Wang K, Zhou W, Wen L, Jin X, Meng T, Li S, Hong Y, Xu Y, Yuan H, Hu F
Experimental neurology 2024 Sep;379:114870
Experimental neurology 2024 Sep;379:114870
Activation of Piezo1 by intracranial hypertension induced neuronal apoptosis via activating hippo pathway.
Zeng J, Fang Z, Duan J, Zhang Z, Wang Y, Wang Y, Chen L, Wang J, Liu F
CNS neuroscience & therapeutics 2024 Sep;30(9):e14872
CNS neuroscience & therapeutics 2024 Sep;30(9):e14872
HSPB8 attenuates lipopolysaccharide‑mediated acute lung injury in A549 cells by activating mitophagy.
Zhou X, Wang M, Sun M, Yao N
Molecular medicine reports 2024 Sep;30(3)
Molecular medicine reports 2024 Sep;30(3)
ESF1 positively regulates MDM2 and promotes tumorigenesis.
Zhang P, Sun C, Yin T, Guo J, Chong D, Tang Y, Liu Y, Li Y, Gu Y, Lu L
International journal of biological macromolecules 2024 Sep;276(Pt 1):133652
International journal of biological macromolecules 2024 Sep;276(Pt 1):133652
Full-length GSDME mediates pyroptosis independent from cleavage.
Zhou B, Jiang ZH, Dai MR, Ai YL, Xiao L, Zhong CQ, Wu LZ, Chen QT, Chen HZ, Wu Q
Nature cell biology 2024 Sep;26(9):1545-1557
Nature cell biology 2024 Sep;26(9):1545-1557
ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats.
Jiang L, Yang S, Deng L, Luo J, Zhang X, Chen S, Dong Z
Biochemical pharmacology 2024 Sep;227:116446
Biochemical pharmacology 2024 Sep;227:116446
Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis.
Xu X, Zhu W, Miao M, Bai M, Fan J, Niu Y, Li Y, Zhang A, Jia Z, Wu M
Chinese journal of natural medicines 2024 Sep;22(9):808-821
Chinese journal of natural medicines 2024 Sep;22(9):808-821
The effects and mechanisms of AM1241 in alleviating cerebral ischemia-reperfusion injury.
Li S, Yang P, Wu Z, Huang W, Zhu X, Zhong L
Brain research bulletin 2024 Sep;215:111025
Brain research bulletin 2024 Sep;215:111025
Pyrimidine compounds BY4003 and BY4008 inhibit glioblastoma cells growth via modulating JAK3/STAT3 signaling pathway.
Ahmad N, Chen L, Yuan Z, Ma X, Yang X, Wang Y, Zhao Y, Jin H, Khaidamah N, Wang J, Lu J, Liu Z, Wu M, Wang Q, Qi Y, Wang C, Zhao Y, Piao Y, Huang R, Diao Y, Deng S, Shu X
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00431
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00431
Aerobic exercise alleviates skeletal muscle aging in male rats by inhibiting apoptosis via regulation of the Trx system.
Bao F, Zhao X, You J, Liu Y, Xu Z, Wu Y, Wu Y, Xu Z, Yu L, Li J, Wei Y
Experimental gerontology 2024 Sep;194:112523
Experimental gerontology 2024 Sep;194:112523
NCI677397 targeting USP24-mediated induction of lipid peroxidation induces ferroptosis in drug-resistant cancer cells.
Wang SA, Wu YC, Yang FM, Hsu FL, Zhang K, Hung JJ
Molecular oncology 2024 Sep;18(9):2255-2276
Molecular oncology 2024 Sep;18(9):2255-2276
Targeting metabolic reprogramming to overcome drug resistance in advanced bladder cancer: insights from gemcitabine- and cisplatin-resistant models.
Kawahara I, Yoshino H, Fukumoto W, Arima J, Saito S, Li G, Fukuda I, Mitsuke A, Sakaguchi T, Inoguchi S, Matsushita R, Nakagawa M, Tatarano S, Yamada Y, Enokida H
Molecular oncology 2024 Sep;18(9):2196-2211
Molecular oncology 2024 Sep;18(9):2196-2211
PKC-δ Promotes IL-1β-Induced Apoptosis of Rat Chondrocytes and Via Activating JNK and P38 MAPK Pathways.
Lu J, Yu M, Li J
Cartilage 2024 Sep;15(3):315-327
Cartilage 2024 Sep;15(3):315-327
Combining the novel FLT3 and MERTK dual inhibitor MRX-2843 with venetoclax results in promising antileukemic activity against FLT3-ITD AML.
Wu S, Liu F, Gai Y, Carter J, Edwards H, Hüttemann M, Wang G, Li C, Taub JW, Wang Y, Ge Y
Leukemia research 2024 Sep;144:107547
Leukemia research 2024 Sep;144:107547
Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.
Ji XY, Feng JT, Zhou ZY, Zhang YY, Ma SZ, Wang XQ, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155853
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155853
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Zhu C, Zhang M, Gong S, Du J, Ma L, Liu Y, Li Y, Yu J, Liu N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Isotoosendanin exerts anti-tumor effects in NSCLC by enhancing the stability of SHP-2 and inhibiting the JAK/STAT3 pathway.
Shu C, Chen Y, Wu Z, Zhang W, Zhao J, Wang Y, Zeng Y, Li J, Zhu J, Yan Z, Liu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155832
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155832
Gastrodin relieves Parkinson's disease-related motor deficits by facilitating the MEK-dependent VMAT2 to maintain dopamine homeostasis.
Zhao M, Zhou Y, Sheng R, Zhang H, Xiang J, Wang J, Li P, Ma T, Liu P, Chen Q, Wen W, Xu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155819
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155819
B. glomerulata promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT/mTOR pathway.
Xu Z, Li Y, Pi P, Yi Y, Tang H, Zhang Z, Xiong H, Lei B, Shi Y, Li J, Sun Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155817
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155817
Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k/akt pathway-mediated apoptosis, autophagy and ferroptosis.
Yan S, Bao S, Chen T, Chen J, Zhang J, Hu X, Liang Y, Zhou X, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155791
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155791
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Zhang M, Li L, Zhang W, Li M, Yan G, Tang C
Cellular signalling 2024 Sep;121:111296
Cellular signalling 2024 Sep;121:111296
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Luo Z, Zheng S, Liu J, Qi F
Cellular signalling 2024 Sep;121:111275
Cellular signalling 2024 Sep;121:111275
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis.
Qiu P, Chang Y, Chen X, Wang S, Nie H, Hong Y, Zhang M, Wang H, Xiao C, Chen Y, Liu L, Zhao Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2403461
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2403461
Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway.
Duan H, Wang F, Wang K, Yang S, Zhang R, Xue C, Zhang L, Ma X, Du X, Kang J, Zhang Y, Zhao X, Hu J, Xiao L
Journal of animal science and biotechnology 2024 Sep 5;15(1):119
Journal of animal science and biotechnology 2024 Sep 5;15(1):119
PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT.
Zhang W, Li W, Yin C, Feng C, Liu B, Xu H, Jin X, Tu C, Li Z
Cancer research 2024 Sep 4;84(17):2873-2887
Cancer research 2024 Sep 4;84(17):2873-2887
CD226 implicated in Akt-dependent apoptosis of CD4(+) T cell contributes to asthmatic pathogenesis.
Zhang Y, Xie Y, Zhang X, Duan C, Ma J, Wang Y, Wu Y, Shan N, Cheng K, Zhuang R, Bian K
Cell death & disease 2024 Sep 30;15(9):705
Cell death & disease 2024 Sep 30;15(9):705
LncRNA OIP5-AS1 regulates ferroptosis and mitochondrial dysfunction-mediated apoptosis in spinal cord injury by targeting the miR-128-3p/Nrf2 axis.
Jiang Z, Zhang W, Zhang J
Heliyon 2024 Sep 30;10(18):e37704
Heliyon 2024 Sep 30;10(18):e37704
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.
Wang YN, Chen XL, Yang J, Gong XX, Zhang HF, Zhang YM, Zeng DF, Chen PS, Chen HB
Placenta 2024 Sep 26;155:32-41
Placenta 2024 Sep 26;155:32-41
Tetrahydroberberine Prevents Ovariectomy-Induced Bone Loss by Inhibiting RANKL-Induced Osteoclastogenesis and Promoting Osteoclast Apoptosis.
Wu Q, Liang H, Wang C, Chen Y, Yu C, Luo J, Cai L, Miao J, Xu J, Jin H, Wang X
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20383-20395
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20383-20395
Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis.
Wang J, Li M, Wu W, Zhang H, Yang Y, Usman M, Aernouts B, Loor JJ, Xu C
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20321-20330
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20321-20330
Palliative effect of rotating magnetic field on glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating osteoblast differentiation.
Yang H, Nie S, Zhou C, Li M, Yu Q, Mo Y, Wei Y, Wang X
Biochemical and biophysical research communications 2024 Sep 17;725:150265
Biochemical and biophysical research communications 2024 Sep 17;725:150265
Dietary bitter ginger-derived zerumbone improved memory performance during aging through inhibition of the PERK/CHOP-dependent endoplasmic reticulum stress pathway.
Yang C, Zhao M, Chen Y, Song J, Wang D, Zou M, Liu J, Wen W, Xu S
Food & function 2024 Sep 16;15(18):9070-9084
Food & function 2024 Sep 16;15(18):9070-9084
Establishment of XRD fourier fingerprint identification method of realgar decoction pieces and its anti-tumor activity in tumor-in-situ transplanted mice.
Qian X, Wang Y, Liu Z, Fang F, Ma Y, Zhou L, Pan Y, Meng X, Yan B, Zhu X, Wang X, Zhao J, Liu S
Journal of ethnopharmacology 2024 Sep 15;331:118303
Journal of ethnopharmacology 2024 Sep 15;331:118303
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Duan ZW, Liu Y, Zhang PP, Hu JY, Mo ZX, Liu WQ, Ma X, Zhou XH, Wang XH, Hu XH, Wei SL
Journal of ethnopharmacology 2024 Sep 15;331:118293
Journal of ethnopharmacology 2024 Sep 15;331:118293
Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway.
Cao Z, Ma N, Shan M, Wang S, Du J, Cheng J, Sun P, Sun N, Jin L, Fan K, Yin W, Li H, Yin C, Sun Y
International journal of molecular sciences 2024 Sep 14;25(18)
International journal of molecular sciences 2024 Sep 14;25(18)
Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway.
He J, Ao C, Li M, Deng T, Zheng S, Zhang K, Tu C, Ouyang Y, Lang R, Jiang Y, Yang Y, Li C, Wu D
Stem cell research & therapy 2024 Sep 13;15(1):300
Stem cell research & therapy 2024 Sep 13;15(1):300
Chitosan-Modified AgNPs Efficiently Inhibit Swine Coronavirus-Induced Host Cell Infections via Targeting the Spike Protein.
Wang D, Yin C, Bai Y, Zhou M, Wang N, Tong C, Yang Y, Liu B
Biomolecules 2024 Sep 13;14(9)
Biomolecules 2024 Sep 13;14(9)
Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.
Zhao X, Zhong C, Zhu R, Gong R, Liu B, He L, Tian S, Jin J, Jiang T, Chen JL, Wan X, Liu W, Jiang S, Deng P, Cheng Y, Ye N
Journal of medicinal chemistry 2024 Sep 12;67(17):15837-15861
Journal of medicinal chemistry 2024 Sep 12;67(17):15837-15861
A New Class of Gold(I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2.
Bannwart F, Richter LF, Stifel S, Rueter J, Lode HN, Correia JDG, Kühn FE, Prokop A
Journal of medicinal chemistry 2024 Sep 12;67(17):15494-15508
Journal of medicinal chemistry 2024 Sep 12;67(17):15494-15508
DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk.
Shi J, Wang Y, Liang T, Wang X, Xie J, Huang R, Xu X, Wei X
Chinese medicine 2024 Sep 12;19(1):125
Chinese medicine 2024 Sep 12;19(1):125
CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway.
Hou C, Yang Y, Wang P, Xie H, Jin S, Zhao L, Wu G, Xing H, Chen H, Liu B, Du C, Sun X, He L
Cell death & disease 2024 Sep 11;15(9):666
Cell death & disease 2024 Sep 11;15(9):666
Minocycline alleviates lipopolysaccharide-induced cardiotoxicity by suppressing the NLRP3/Caspase-1 signaling pathway.
Li H, Li X, Xu G, Zhan F
Scientific reports 2024 Sep 11;14(1):21180
Scientific reports 2024 Sep 11;14(1):21180
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Niu Q, Li D, Guo W, Feng Z, Han Z, Yang Y
BMC endocrine disorders 2024 Sep 10;24(1):184
BMC endocrine disorders 2024 Sep 10;24(1):184
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
Ye P, Liu H, Qin Y, Li Z, Huang Z, Bu X, Peng Q, Duan N, Wang W, Wang X
Chemico-biological interactions 2024 Sep 1;400:111166
Chemico-biological interactions 2024 Sep 1;400:111166
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Sun Y, Li R, Li W, Zhang N, Liu G, Zhao B, Mei Z, Gu S, He Z
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Role of secreted frizzled-related protein 5 in granulosa cells of hu sheep ovaries.
Yang F, Li X, Zhou L, Cai Y, Kang Z, Liu Z, Yao X, Wang F
Theriogenology 2024 Sep 1;225:142-151
Theriogenology 2024 Sep 1;225:142-151
IGF-1 inhibits inflammation and accelerates angiogenesis via Ras/PI3K/IKK/NF-κB signaling pathways to promote wound healing.
Zhang X, Hu F, Li J, Chen L, Mao YF, Li QB, Nie CY, Lin C, Xiao J
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Sep 1;200:106847
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Sep 1;200:106847
Win-win integration: A mitochondria targeted AIE photosensitizer for hypochlorite detection and type I & type II photodynamic therapy.
Ni J, Yu L, Wang Y, Yang T, Bai Y, Zheng B, Liang M, Ye X, Quan YY, Lin F, Huang ZS
Analytica chimica acta 2024 Sep 1;1320:343035
Analytica chimica acta 2024 Sep 1;1320:343035
Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway.
Fei X, Li Z, Pan Z, Liang Y, Tan C, Cheng D, Yang Q
Cancer chemotherapy and pharmacology 2024 Oct;94(4):599-613
Cancer chemotherapy and pharmacology 2024 Oct;94(4):599-613
LncRNA PCIF1 promotes aerobic glycolysis in A549/DDP cells by competitively binding miR-326 to regulate PKM expression.
Zhong W, Wang C, Sun Y
Molecular and cellular probes 2024 Oct;77:101977
Molecular and cellular probes 2024 Oct;77:101977
Inhibiting lncRNA NEAT1 Increases Glioblastoma Response to TMZ by Reducing Connexin 43 Expression.
Liang J, Xie JX, He J, Li Y, Wei D, Zhou R, Wei G, Liu X, Chen Q, Li D
Cancer reports (Hoboken, N.J.) 2024 Oct;7(10):e70031
Cancer reports (Hoboken, N.J.) 2024 Oct;7(10):e70031
Ginsenoside Rg1 treats chronic heart failure by downregulating ERK1/2 protein phosphorylation.
Peng L, Li S, Cai H, Chen X, Tang Y
In vitro cellular & developmental biology. Animal 2024 Oct;60(9):1085-1098
In vitro cellular & developmental biology. Animal 2024 Oct;60(9):1085-1098
HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA.
Jin T, Wang Z, Fan F, Wei W, Zhou C, Zhang Z, Gao Y, Li W, Zhu L, Hao J
Neurochemical research 2024 Oct;49(10):2699-2724
Neurochemical research 2024 Oct;49(10):2699-2724
Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway.
Zhao Z, Wu Q, Xu Y, Qin Y, Pan R, Meng Q, Li S
Journal of bone oncology 2024 Oct;48:100631
Journal of bone oncology 2024 Oct;48:100631
Mangiferin activates the nuclear factor erythroid 2-related factor pathway to protect SOD1-G93A induced NSC-34 motor neurons from oxidative stress and apoptosis.
Su B, He Z, Liu J, Li M, Huang X
Journal of biochemical and molecular toxicology 2024 Oct;38(10):e23849
Journal of biochemical and molecular toxicology 2024 Oct;38(10):e23849
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Ding SM, Shi LG, Xing F, Cui SS, Cheng HR, Liu Y, Ji DM, Liang D, Cao YX, Liu YJ
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation.
Shen Z, Zhao L, Yoo SA, Lin Z, Zhang Y, Yang W, Piao J
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1810-1823
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1810-1823
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives.
Sun X, Chen J, Huang D, Ding F, Zhao L, Li HM, Wang XS, Zhang YX, Wu CZ
Molecular diversity 2024 Oct;28(5):2749-2758
Molecular diversity 2024 Oct;28(5):2749-2758
Lenvatinib acts on platelet‑derived growth factor receptor β to suppress the malignant behaviors of gastric cancer cells.
Tong X, Du J, Jiang Q, Wu Q, Zhao S, Chen S
Oncology letters 2024 Oct;28(4):483
Oncology letters 2024 Oct;28(4):483
The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1.
Feng Y, Zhang Z, Yang H, Miao F, Li Y, Zhang M, Cao Y, Li M
Journal of cellular and molecular medicine 2024 Oct;28(20):e70106
Journal of cellular and molecular medicine 2024 Oct;28(20):e70106
Study on the mechanism of macrophages activated by phosphoesterified rehmanniae polysaccharide on human gastric cancer cells.
Liu X, Yang F, Ren P, Lv W, Chen B, Niu B, Ren Y, Wang L, Sun M, Zuo Z, Li J, Geng A
International journal of biological macromolecules 2024 Oct;277(Pt 1):133952
International journal of biological macromolecules 2024 Oct;277(Pt 1):133952
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax.
Zhao J, Wu S, Wang D, Edwards H, Thibodeau J, Kim S, Stemmer P, Wang G, Jin J, Savasan S, Taub JW, Ge Y
Biochemical pharmacology 2024 Oct;228:116065
Biochemical pharmacology 2024 Oct;228:116065
Huperzine A targets Apolipoprotein E: A potential therapeutic drug for diabetic nephropathy based on omics analysis.
Chen X, Zhang Y, Cao Z, Wang Y, Liao M, Guan Y, Zhu C, Wang W, Huang W, Li W, Xiao Y, Li Y, Yin J, Ding Y, Peng Q, Hu L
Pharmacological research 2024 Oct;208:107392
Pharmacological research 2024 Oct;208:107392
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Pan F, Yang W, Zhao T, Liu K, Zhao S, Zhao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis.
Wang J, Gui R, Li Y, Li Z, Li Z, Liu S, Zhang M, Qian L, Fan X, Xiong Y
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119822
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119822
Methylglyoxal induces endothelial cell apoptosis and coronary microvascular dysfunction through regulating AR-cPLA(2) signaling.
Wan R, Zhou J, Mao R, Zheng Y, Zhou F, Pan L, Hong Y, Jin L, Li S, Zhu C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167437
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167437
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Huang L, Ye Y, Sun Y, Zhou Z, Deng T, Liu Y, Wu R, Wang K, Yao C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Preparation of photo-controlled release ROS-responsive Ce6/elemene co-loaded liposomes and study on the effect on enhancing apoptosis of NMIBC.
Zhang X, Mei W, Guo D, Sun J, Shi Y, Zhang X, Zou J, Cheng J, Luan F, Zhai B, Tian H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117398
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117398
Effects of exogenous hydrogen sulfide and honokiol intervention on the proliferation, apoptosis, and calcium signaling pathway of rat enteric glial cells.
Liu P, Zhang X, Zhao N, Dai J, Liang G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117290
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117290
A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus.
Wang L, Yin H, Jiang J, Li Q, Gao C, Li W, Zhang B, Xin Y, Li H, Zhao M, Lu Q
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4560-4576
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4560-4576
The expression and role of SUZ12 in lung adenocarcinoma.
Hu X, Hu C, Zhong P
Cancer medicine 2024 Oct;13(19):e70190
Cancer medicine 2024 Oct;13(19):e70190
Modified EBP-bFGF targeting endogenous renal extracellular matrix protects against renal ischemia-reperfusion injury in rats.
Li X, Shi C, Zhou R, Chen X, Xu Q, Zhao C, Ma M, Ao X, Liu Y
Journal of biomedical materials research. Part A 2024 Oct;112(10):1827-1839
Journal of biomedical materials research. Part A 2024 Oct;112(10):1827-1839
N-Acetylcysteine assists muscle development in offspring of mice subjected to maternal heat stress during pregnancy.
Lu J, Zhao P, Ding X, Liu Y, Li H
Journal of the science of food and agriculture 2024 Oct;104(13):7895-7906
Journal of the science of food and agriculture 2024 Oct;104(13):7895-7906
Effect of dapagliflozin on pulmonary vascular remodeling in rats with chronic hypoxic pulmonary arterial hypertension.
Xu Y, Liang W, Huo J, Zhang T, Feng T, Li M, Zhu Z, Zhou P, Zhu S, Lu Y, Wang L
Journal of receptor and signal transduction research 2024 Oct-Dec;44(5-6):174-180
Journal of receptor and signal transduction research 2024 Oct-Dec;44(5-6):174-180
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Li J, Feng L, Yuan Y, He T, Zou X, Su B, Liu K, Yang X
World journal of surgical oncology 2024 Oct 8;22(1):268
World journal of surgical oncology 2024 Oct 8;22(1):268
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Yang J, Cong N, Shi D, Chen S, Zhang Z, Zhao P
Journal of ethnopharmacology 2024 Oct 5;332:118366
Journal of ethnopharmacology 2024 Oct 5;332:118366
Flavopiridol induces cell cycle arrest and apoptosis by interfering with CDK1 signaling pathway in human ovarian granulosa cells.
Li XZ, Song W, Zhao ZH, Lu YH, Xu GL, Yang LJ, Yin S, Sun QY, Chen LN
Scientific reports 2024 Oct 31;14(1):26239
Scientific reports 2024 Oct 31;14(1):26239
PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms.
Cao T, Wang J
Translational cancer research 2024 Oct 31;13(10):5627-5648
Translational cancer research 2024 Oct 31;13(10):5627-5648
MiR-155-5p regulates autophagy and apoptosis of glioma cells through RICTOR.
Guo Z, Tian JJ, Wang Y, Jiang L, Chen Y, Dai HJ, Wang L, Zhang Y
Translational cancer research 2024 Oct 31;13(10):5509-5521
Translational cancer research 2024 Oct 31;13(10):5509-5521
Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages.
Ren Y, You X, Zhu R, Li D, Wang C, He Z, Hu Y, Li Y, Liu X, Li Y
Microbiology spectrum 2024 Oct 3;12(10):e0414623
Microbiology spectrum 2024 Oct 3;12(10):e0414623
Mechanistic insights into xanthomicrol as the active anti-HCC ingredient of Phytolacca acinosa Roxb.: A network pharmacology analysis and transcriptomics integrated experimental verification.
Liu J, Zhou Y, Zhou P, He T, Liu P, Wang J, Lin P, Hou J, Sun H, Ma H
Journal of ethnopharmacology 2024 Oct 28;333:118467
Journal of ethnopharmacology 2024 Oct 28;333:118467
Mechanism of Zhishi Xiebai Guizhi decoction to treat atherosclerosis: Insights into experiments, network pharmacology and molecular docking.
Zhang Z, Gao J, Wang J, Mi Z, Li H, Dai Z, Pan Y, Dong J, Chen S, Lu S, Tan X, Chen H
Journal of ethnopharmacology 2024 Oct 28;333:118466
Journal of ethnopharmacology 2024 Oct 28;333:118466
Taohong Siwu decoction alleviates cognitive impairment by suppressing endoplasmic reticulum stress and apoptosis signaling pathway in vascular dementia rats.
Fan LL, Fang H, Zheng JY, Qiu YH, Wu GL, Cai YF, Chen YB, Zhang SJ
Journal of ethnopharmacology 2024 Oct 28;333:118407
Journal of ethnopharmacology 2024 Oct 28;333:118407
Erianin inhibits the progression of pancreatic cancer by directly targeting AKT and ASK1.
Liu R, Qiu M, Deng X, Zhang M, Gao Z, Wang Y, Mei H, Zhai M, Zhang Q, Hao J, Yang Z, Wang H
Cancer cell international 2024 Oct 25;24(1):348
Cancer cell international 2024 Oct 25;24(1):348
Promotion of Raf-1/ASK1 complex formation by corylin inhibits cell apoptosis in myocardial ischemia/reperfusion injury.
Huang K, Cai C, He H, Yi B, Xu W, Lin Z, Lv X, Liu R, Zheng C, Zhou Y, Lin J
International immunopharmacology 2024 Oct 25;140:112921
International immunopharmacology 2024 Oct 25;140:112921
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway.
Liu Y, Chen C, Hao Z, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
MYO6 contributes to tumor progression and enzalutamide resistance in castration-resistant prostate cancer by activating the focal adhesion signaling pathway.
Zheng S, Hong Z, Tan Y, Wang Y, Li J, Zhang Z, Feng T, Hong Z, Lin G, Ye D
Cell communication and signaling : CCS 2024 Oct 24;22(1):517
Cell communication and signaling : CCS 2024 Oct 24;22(1):517
Synergistic effects of bloom helicase (BLM) inhibitor AO/854 with cisplatin in prostate cancer.
Ma X, Tian F, Xiao Y, Huang M, Song D, Chen X, Xu H
Scientific reports 2024 Oct 23;14(1):24962
Scientific reports 2024 Oct 23;14(1):24962
Gentiopicroside Attenuates Lithium/Pilocarpine-Induced Epilepsy Seizures by Down-Regulating NR2B/CaMKII/CREB and TLR4/NF-κB Signaling Pathways in the Hippocampus of Mice.
Tian MM, Liu G, Du J, Liu Y, Wei W, Lan XB, Hai DM, Ma L, Yu JQ, Liu N
Pharmaceuticals (Basel, Switzerland) 2024 Oct 22;17(11)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 22;17(11)
Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway.
Wang H, Wei Z, Xu C, Fang F, Wang Z, Zhong Y, Wang X
Scientific reports 2024 Oct 21;14(1):24787
Scientific reports 2024 Oct 21;14(1):24787
Fluid shear stress-mediated Piezo1 alleviates osteocyte apoptosis by activating the PI3K/Akt pathway.
Zhan H, Xie D, Yan Z, Yi Z, Xiang D, Niu Y, Liang X, Geng B, Wu M, Xia Y, Jiang J
Biochemical and biophysical research communications 2024 Oct 20;730:150391
Biochemical and biophysical research communications 2024 Oct 20;730:150391
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Yang Y, Liu X, Liu W, Zhou X, Zhang Z, Hu Y, Liu P, Li X, Liu H, Li S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.
Long B, Zhou H, Xiao L, Jiang X, Li J, Ma Z, He N, Xin W, Zhang B, Zhu X, Yu Z, Jiao Z
Chinese medical journal 2024 Oct 20;137(20):2437-2451
Chinese medical journal 2024 Oct 20;137(20):2437-2451
Regorafenib promotes antitumor progression in melanoma by reducing RRM2.
Xuan X, Li Y, Huang C, Zhang Y
iScience 2024 Oct 18;27(10):110993
iScience 2024 Oct 18;27(10):110993
Apoptosis, Mitochondrial Autophagy, Fission, and Fusion Maintain Mitochondrial Homeostasis in Mouse Liver Under Tail Suspension Conditions.
Li LF, Yu J, Li R, Li SS, Huang JY, Wang MD, Jiang LN, Xu JH, Wang Z
International journal of molecular sciences 2024 Oct 18;25(20)
International journal of molecular sciences 2024 Oct 18;25(20)
The deubiquitinase OTUD3 stabilizes IRP2 expression to reduce hippocampal neuron ferroptosis via the p53/PTGS2 pathway to ameliorate cerebral ischemia-reperfusion injury.
Hou D, Hu Y, Yun T, Li H, Yang G, Yu D
European journal of medical research 2024 Oct 17;29(1):498
European journal of medical research 2024 Oct 17;29(1):498
Elevated circulating LncRNA NORAD fosters endothelial cell growth and averts ferroptosis by modulating the miR-106a/CCND1 axis in CAD patients.
He T, Pu J, Ge H, Liu T, Lv X, Zhang Y, Cao J, Yu H, Lu Z, Du F
Scientific reports 2024 Oct 16;14(1):24223
Scientific reports 2024 Oct 16;14(1):24223
Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1.
Wang S, Li X, Wang T, Sun Z, Feng E, Jin Y
Communications biology 2024 Oct 15;7(1):1330
Communications biology 2024 Oct 15;7(1):1330
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease.
Yang X, Liu H, Cheng S, Pan C, Cai Q, Chu X, Shi S, Wei W, He D, Cheng B, Wen Y, Jia Y, Tinkov AA, Skalny AV, Zhang F
Ecotoxicology and environmental safety 2024 Oct 15;285:117148
Ecotoxicology and environmental safety 2024 Oct 15;285:117148
Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure.
Xu T, Du T, Zhuang X, He X, Yan Y, Wu J, Zhou H, Li Y, Liao X, He J, Liu C, Dong Y, Ou J, Lin S, Chen D, Huang ZP
Journal of the American Heart Association 2024 Oct 15;13(20):e035714
Journal of the American Heart Association 2024 Oct 15;13(20):e035714
LncRNA Pvt1 aggravates cardiomyocyte apoptosis via the microRNA-216/Ccnd3 axis.
Hu Y, Luo M, Xue Y, Lv D, Huang L, Li X, Shen J
Heliyon 2024 Oct 15;10(19):e38261
Heliyon 2024 Oct 15;10(19):e38261
A quinoline-2-thione derivative as a novel chemotherapy drug candidate displays anti-tumor activity in vitro and in vivo.
Zhao JJ, Zhao J, Lin F, Xu LL, Chen ZG, Jiang YQ, Zhao GA
BMC cancer 2024 Oct 13;24(1):1272
BMC cancer 2024 Oct 13;24(1):1272
Discovery of SIRT1-Activating Hydrogen Sulfide Donating Derivatives for Efficient Resistant of Myocardial Ischemic Injury.
Wang S, Feng D, Wang W, Zheng C, Liang C, Li S, Li H, Xu F, Cao H, Hua H, Cheng M, Li D
Journal of medicinal chemistry 2024 Oct 10;67(19):17657-17675
Journal of medicinal chemistry 2024 Oct 10;67(19):17657-17675
Downregulation of CASC15 attenuates the symptoms of polycystic ovary syndrome by affecting granulosa cell proliferation and regulating ovarian follicular development.
Zhang T, Fang J, Hu J, Kong Y, Jiang R, Wang H, Yang G, Yao G
Molecular and cellular endocrinology 2024 Oct 1;592:112322
Molecular and cellular endocrinology 2024 Oct 1;592:112322
Deficiency in the Rab25 gene leads to a decline in male fertility and testicular injury: Impact on the regulation of germ cell proliferation and apoptosis.
Zhang Q, Zhang Z, Liu Z, Wang C, Chen H, Shen L, Long C, Wei G, Liu X
Experimental cell research 2024 Oct 1;442(2):114285
Experimental cell research 2024 Oct 1;442(2):114285
Regulation of cervical cancer via G15-mediated inhibition of G protein-coupled estrogen receptor.
Zhu Z, Nie X, Deng L, Ding J, Chen J, Zhu J, Yin X, Guo B, Zhang F
Anti-cancer drugs 2024 Oct 1;35(9):817-829
Anti-cancer drugs 2024 Oct 1;35(9):817-829
Donafenib inhibits PARP1 expression and induces DNA damage, in combination with PARP1 inhibitors promotes apoptosis in liver cancer cells.
Jiang J, Yang P, Xu X, Yuan H, Zhu H
Anti-cancer drugs 2024 Oct 1;35(9):789-805
Anti-cancer drugs 2024 Oct 1;35(9):789-805
Fluorene-9-bisphenol impaired male fertility through disrupting the testicular function and local microenvironment.
Jiang D, Yang Y, Han X, Li Q, Li P, Xu Y, Chao L
Ecotoxicology and environmental safety 2024 Oct 1;284:116880
Ecotoxicology and environmental safety 2024 Oct 1;284:116880
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Li Y, Wang Y, Jiang Z, Yang C, Wu Y, Wu A, Zhang Q, Liu X, Xiao B, Feng Y, Wu J, Liang Z, Yuan Z
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
RBM5 induces motor neuron apoptosis in hSOD1(G93A)-related amyotrophic lateral sclerosis by inhibiting Rac1/AKT pathways.
Tan X, Su X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Feng H
Brain research bulletin 2024 Oct 1;216:111049
Brain research bulletin 2024 Oct 1;216:111049
The effect of repetitive magnetic stimulation on neuronal apoptosis and PI3K/Akt protein expression in rats with incomplete spinal cord injury.
Su J, Zhou F, Hu M, Xu Q, Huang Y, Chen S, Zhou H, Chen H
Journal of neurophysiology 2024 Oct 1;132(4):1211-1222
Journal of neurophysiology 2024 Oct 1;132(4):1211-1222
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Lan X, Wang Q, Liu Y, You Q, Wei W, Zhu C, Hai D, Cai Z, Yu J, Zhang J, Liu N
Redox biology 2024 Nov;77:103406
Redox biology 2024 Nov;77:103406
Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress.
Shen Z, Wang J, Chen Y, Fang P, Yuan A, Chen AF, Yan X, Lyu Y, Pu J
Redox biology 2024 Nov;77:103397
Redox biology 2024 Nov;77:103397
Surface nanocoating-based universal platform for programmed delivery of microorganisms in complicated digestive tract.
Du Y, Guo HL, Su X, Guo M, Li B, Wang H, Gao X, Yuan Q, Teng Y, Wang T, Zheng B
Journal of colloid and interface science 2024 Nov;673:765-780
Journal of colloid and interface science 2024 Nov;673:765-780
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
Combined treatment with Aronia berry extract and oligomeric proanthocyanidins exhibit a synergistic anticancer efficacy through LMNB1-AKT signaling pathways in colorectal cancer.
Li Y, Xu C, Weng W, Goel A
Molecular carcinogenesis 2024 Nov;63(11):2145-2157
Molecular carcinogenesis 2024 Nov;63(11):2145-2157
Resolvin E1 and Inhibition of BLT2 Signaling Attenuate the Inflammatory Response and Improve One-Lung Ventilation-Induced Lung Injury.
Ji L, Liu G, Yu G, Xia C, Liu S, Lan Y
Immunological investigations 2024 Nov;53(8):1293-1307
Immunological investigations 2024 Nov;53(8):1293-1307
Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway.
Liu S, Li J, Wang W, Zhang Y, Li S, Li T, Jiang J, Zhao F
Toxicology 2024 Nov;508:153925
Toxicology 2024 Nov;508:153925
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
Du J, Zhou P, Zhao X, He YT, He CS, Wang RY
Toxicology and applied pharmacology 2024 Nov;492:117127
Toxicology and applied pharmacology 2024 Nov;492:117127
PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes.
Liu Y, Wei Y, Jin X, Cai H, Chen Q, Zhang X
Diabetes & metabolism journal 2024 Nov;48(6):1058-1072
Diabetes & metabolism journal 2024 Nov;48(6):1058-1072
Naringin Induces ROS-Stimulated G(1) Cell-Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Cells.
Chen CH, Tien N, Yao CH, Chen SJ, Bau DT, Pandey S, Yang HL, Hseu YC, Chen SS, Lin ML
Environmental toxicology 2024 Nov;39(11):5059-5073
Environmental toxicology 2024 Nov;39(11):5059-5073
Silver Nanoparticles Loaded With Oleuropein Alleviates LPS-Induced Acute Lung Injury by Modulating the TLR4/P2X7 Receptor-Mediated Inflammation and Apoptosis in Rats.
Yakut S, Gelen V, Kara H, Özkanlar S, Yeşildağ A
Environmental toxicology 2024 Nov;39(11):4960-4973
Environmental toxicology 2024 Nov;39(11):4960-4973
Ferulic Acid Protects Human Lens Epithelial Cells Against UVA-Induced Oxidative Damage by Downregulating the DNA Demethylation of the Keap1 Promoter.
Ling X, Zhu L, Yan Y, Qian H, Kang Z, Ye W, Xie Z, Xue C
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70031
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70031
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao C, Liu H
Cell death and differentiation 2024 Nov;31(11):1410-1421
Cell death and differentiation 2024 Nov;31(11):1410-1421
High levels of mitochondrial dynamics, autophagy, and apoptosis contribute to stable testicular status in hibernating Daurian ground squirrels.
Wang Z, Wang MD, Wang XC, Chen L, Li LF, Jiang LN, Xu JH, Kai Dang
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2024 Nov;297:111705
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2024 Nov;297:111705
A novel format of TNF-α binding affibody molecule ameliorate coronary artery endothelial injury in a mouse model of Kawasaki disease.
Zhu J, Yu H, Xie L, Shuai D, Huang Z, Chen Y, Ni C, Jia C, Rong X, Zhang L, Chu M
International journal of biological macromolecules 2024 Nov;281(Pt 1):136255
International journal of biological macromolecules 2024 Nov;281(Pt 1):136255
The dual role of ATG7: Regulation of autophagy and apoptosis in porcine ovarian follicular granulosa cells.
Xing W, Wang B, Li M, Qi N, Liu J
Animal reproduction science 2024 Nov;270:107601
Animal reproduction science 2024 Nov;270:107601
β-Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway.
Zhuang H, Ren X, Zhang Y, Li H, Zhou P
Aging cell 2024 Nov;23(11):e14294
Aging cell 2024 Nov;23(11):e14294
Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer.
Wu J, Zhang R, Yin Z, Chen X, Mao R, Zheng X, Yuan M, Li H, Lu Y, Liu S, Gao X, Sun Q
Pharmacological research 2024 Nov;209:107476
Pharmacological research 2024 Nov;209:107476
Small Nuclear Ribonucleoprotein Polypeptides B and B1 Promote Osteosarcoma Progression via Activating the Ataxia-Telangiectasia Mutated Signaling Pathway through Ribonucleotide Reductase Subunit M2.
Shi Y, Wang Z, Zhang J, He P, Yang M, Zhao C, Li B, Qian M
The American journal of pathology 2024 Nov;194(11):2163-2178
The American journal of pathology 2024 Nov;194(11):2163-2178
L-NRB alleviates amyotrophic lateral sclerosis by regulating P11-Htr4 signaling pathway.
Pan Y, Sun X, Tian Y, Yu M, Luo Y, Sun X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117588
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117588
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer.
Xu C, Huang X, Hu Q, Xue W, Zhou K, Li X, Nan Y, Ju D, Wang Z, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117550
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117550
Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy.
Li D, Yuan X, Ma J, Lu T, Zhang J, Liu H, Zhang G, Wang Y, Liu X, Xie Q, Zhou L, Xu M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117510
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117510
Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury.
Guo Q, Liu Q, Zhou S, Lin Y, Lv A, Zhang L, Li L, Huang F
Neurochemistry international 2024 Nov;180:105885
Neurochemistry international 2024 Nov;180:105885
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Zhu J, Lin Y, Li G, He Y, Su Z, Tang Y, Zhang Y, Xu Q, Yao Z, Zhou H, Liu B, Cai X
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Wang N, Liu Y, Peng D, Zhang Q, Zhang Z, Xu L, Yin L, Zhao X, Lu Z, Peng J
Advanced healthcare materials 2024 Nov;13(28):e2401646
Advanced healthcare materials 2024 Nov;13(28):e2401646
CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.
Yang Y, Wang Z, Wang N, Yang J, Yang L
Cancer medicine 2024 Nov;13(21):e70286
Cancer medicine 2024 Nov;13(21):e70286
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Huang G, Zhang J, Xu Y, Wu F, Fu Y, Zhang X, Yin H, You Y, Zhao P, Liu W, Shen J, Yin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis.
Sun Z, He W, Meng H, Ji Z, Qu J, Yu G
Respiratory research 2024 Nov 9;25(1):401
Respiratory research 2024 Nov 9;25(1):401
Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma.
Dong H, Sun K, Wang X, Cui M, Ma Y, Li K, Duan W, Zhang H, Zhang L, Sheng Z, He M, Zhang B
Acta biochimica et biophysica Sinica 2024 Nov 8;57(3):403-414
Acta biochimica et biophysica Sinica 2024 Nov 8;57(3):403-414
Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation.
Su HX, Xu LL, Li PB, Bi HL, Jiang WX, Li HH
Cell death & disease 2024 Nov 8;15(11):803
Cell death & disease 2024 Nov 8;15(11):803
NEDD4L Suppresses Proliferation and Promotes Apoptosis by Ubiquitinating RAC2 Expression and Acts as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.
Qi M, Tu J, He R, Fei X, Zhao Y
International journal of molecular sciences 2024 Nov 6;25(22)
International journal of molecular sciences 2024 Nov 6;25(22)
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Hua D, Huang W, Xie Q, Xu W, Tang L, Liu M, Wu X, Zhang Q, Cao X, Li P, Sheng Y
Communications biology 2024 Nov 5;7(1):1441
Communications biology 2024 Nov 5;7(1):1441
The Inhibitory Effect and Mechanism of the Histidine-Rich Peptide rAj-HRP from Apostichopus japonicus on Human Colon Cancer HCT116 Cells.
Zhang Y, Gao S, Mao J, Song Y, Wang X, Jiang J, Lv L, Zhou Z, Wang J
Molecules (Basel, Switzerland) 2024 Nov 4;29(21)
Molecules (Basel, Switzerland) 2024 Nov 4;29(21)
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
PTGS2/GRP78 Activation Triggers Endoplasmic Reticulum Stress Leading to Lipid Metabolism Disruption and Cell Apoptosis, Exacerbating Damage in Bovine Mastitis.
Chen Y, Fang B, Liu X, Bai W, Liu P, Duan Z, Lu T, Zhang Q, Dong W, Zhang Y
Biomolecules 2024 Nov 29;14(12)
Biomolecules 2024 Nov 29;14(12)
HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis.
Zou HM, Yu J, Ruan YY, Xie Y, An XM, Chen PL, Luo YQ, Shi MJ, Liu M, Xu LF, Liu J, Guo B, Zhang F
Lupus science & medicine 2024 Nov 27;11(2)
Lupus science & medicine 2024 Nov 27;11(2)
Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12.
Xie Y, Yang Z, Chen W, Zhong C, Li M, Zhang L, Cheng T, Deng Q, Wang H, Ju J, Du Z, Liang H
Cell & bioscience 2024 Nov 22;14(1):142
Cell & bioscience 2024 Nov 22;14(1):142
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.
Wei J, Chai Q, Qin Y, Li L, Guo C, Lu Z, Liu H
Molecular medicine (Cambridge, Mass.) 2024 Nov 21;30(1):224
Molecular medicine (Cambridge, Mass.) 2024 Nov 21;30(1):224
Effect and underlying mechanism of a photochemotherapy dual-function nanodrug delivery system for head and neck squamous cell carcinoma.
Lin Q, Liu HM, Wu LZ, Yu DD, Hua CY, Zou Y, Jiao WE, Li XP, Chen SM
Journal of translational medicine 2024 Nov 19;22(1):1043
Journal of translational medicine 2024 Nov 19;22(1):1043
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway.
Ni J, Zhang Q, Jiang L, Wang H, Zhang C, Deng J
Scientific reports 2024 Nov 16;14(1):28327
Scientific reports 2024 Nov 16;14(1):28327
Ankrd1 regulates endogenous cardiac regeneration in mice by modulating cyclin D1.
Liu L, Jiang Q, Du C, Yang T, Zhou L, Chen J, Gu L, Wang Q, Wang Z, Wang H, Wang L
European journal of pharmacology 2024 Nov 15;983:177005
European journal of pharmacology 2024 Nov 15;983:177005
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury.
Zhu X, Lin Q, Yang Y, Li S, Shao X, Zhang W, Cai H, Li J, Wu J, Zhang K, Qi C, Zhang M, Che X, Gu L, Ni Z
Cellular and molecular life sciences : CMLS 2024 Nov 15;81(1):454
Cellular and molecular life sciences : CMLS 2024 Nov 15;81(1):454
Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.
Bai L, Chen Q, Li Y, Wu F, Jin M, Chen Y, Teng X, Jin S, Fan H, Wu Y
Physiological research 2024 Nov 15;73(5):779-789
Physiological research 2024 Nov 15;73(5):779-789
DNA Damage-Sensitized metal phenolic nanosynergists potentiate Low-Power phototherapy for osteosarcoma therapy.
Song C, Wu F, Yao S, Chen H, Chen R, Chen X, Lin L, Xu X, Xie L
Journal of colloid and interface science 2024 Nov 15;674:1025-1036
Journal of colloid and interface science 2024 Nov 15;674:1025-1036
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q
Life sciences 2024 Nov 15;357:123084
Life sciences 2024 Nov 15;357:123084
Gastrodin against oxidative stress-inflammation crosstalk via inhibiting mtDNA/TLR9 and JAK2/STAT3 signaling to ameliorate ischemic stroke injury.
Zhang M, Zhang Y, Peng J, Huang Y, Gong Z, Lu H, Han L, Wang D
International immunopharmacology 2024 Nov 15;141:113012
International immunopharmacology 2024 Nov 15;141:113012
SHANK2-AS3: A potential biomarker for Parkinson's disease and its role in neuronal apoptosis via NF-κB signaling in SH-SY5Y cells.
Huang Q, Qin D, Chen C, Kang Y, Chen H, Xu M, Fu R, Dong X
Heliyon 2024 Nov 15;10(21):e38822
Heliyon 2024 Nov 15;10(21):e38822
Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) Against Non-Small-Cell Lung Cancer: Elucidating Effective Ingredients and Mechanism of Action.
Cao Y, Hao Z, Liu M, Xue J, Wang Y, Wang Y, Li J, Lu Y, Wang C, Shi J
Pharmaceuticals (Basel, Switzerland) 2024 Nov 11;17(11)
Pharmaceuticals (Basel, Switzerland) 2024 Nov 11;17(11)
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
Li J, Zhu X, Ye S, Dong Q, Hou J, Liu J, She W
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
The attenuating effects of serine against cadmium induced immunotoxicity through regulating M1/M2 and Th1/Th2 balance in spleen of C57BL/6 mice.
Wang X, Ali W, Zhang K, Ma Y, Zou H, Tong X, Zhu J, Song R, Zhao H, Liu Z, Dong W
Ecotoxicology and environmental safety 2024 Nov 1;286:117216
Ecotoxicology and environmental safety 2024 Nov 1;286:117216
Proteomic Analysis Reveals Major Proteins and Pathways That Mediate the Effect of 17-β-Estradiol in Cell Division and Apoptosis in Breast Cancer MCF7 Cells.
Zhou Z, Sicairos B, Zhou J, Du Y
Journal of proteome research 2024 Nov 1;23(11):4835-4848
Journal of proteome research 2024 Nov 1;23(11):4835-4848
Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury.
Cao J, Yu X, Liu J, Fu J, Wang B, Wu C, Zhang S, Chen H, Wang Z, Xu Y, Sui T, Chang J, Cao X
Neural regeneration research 2024 Nov 1;19(11):2499-2512
Neural regeneration research 2024 Nov 1;19(11):2499-2512
Luteolin prevents cadmium-induced PC12 cell death by suppressing the Akt/mTOR signaling pathway.
Zhang X, Xu W, Li H, Ruan D, Chen S, Chu N, Zhen Q, Wang Y
Medicine 2024 Nov 1;103(44):e40372
Medicine 2024 Nov 1;103(44):e40372
Chlorogenic acid improves the development of porcine parthenogenetic embryos by regulating oxidative stress and ameliorating mitochondrial function.
Qu HX, Wang YQ, Dong YW, Qi JJ, Wei HK, Zhang Y, Sun H, Sun BX, Liang S
Reproduction in domestic animals = Zuchthygiene 2024 May;59(5):e14596
Reproduction in domestic animals = Zuchthygiene 2024 May;59(5):e14596
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Song X, Wang L, Cai P, Xu Y, Liu Q, Fan D
Toxicology and applied pharmacology 2024 May;486:116938
Toxicology and applied pharmacology 2024 May;486:116938
Flavokawain B inhibits NF-κB inflammatory signaling pathway activation in inflammatory bowel disease by targeting TLR2.
Chen Y, Jin T, Zhang M, Hong B, Jin B, Hu C, Wang J, Chen Y, Zhang L, Wang Y, Huang L
Toxicology and applied pharmacology 2024 May;486:116922
Toxicology and applied pharmacology 2024 May;486:116922
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.
Xu Y, Zhou Y, Yi X, Nie X
Cell biology international 2024 May;48(5):626-637
Cell biology international 2024 May;48(5):626-637
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap.
Lai Y, Yang N, Chen X, Ma X, Chen Z, Dong C, Yu G, Huang Y, Shi D, Fang P, Fu K, Jiang R, Mao C, Ding J, Gao W
Phytotherapy research : PTR 2024 May;38(5):2539-2559
Phytotherapy research : PTR 2024 May;38(5):2539-2559
Carnosol alleviates sepsis-induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2-related factor 2/sirtuin-3 signaling pathway to attenuate oxidative damage.
Li X, Wang S, Luo M, Wang M, Wu S, Liu C, Wang F, Li Y
Phytotherapy research : PTR 2024 May;38(5):2182-2197
Phytotherapy research : PTR 2024 May;38(5):2182-2197
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.
Yao L, Cong R, Zhou X, Zhou X, Ji C, Wei X, Meng X, Song N
International journal of impotence research 2024 May;36(3):283-290
International journal of impotence research 2024 May;36(3):283-290
Selective Organ-Targeting Hafnium Oxide Nanoparticles with Multienzyme-Mimetic Activities Attenuate Radiation-Induced Tissue Damage.
Liu D, Cao F, Xu Z, Zhao C, Liu Z, Pang J, Liu ZX, Moghiseh M, Butler A, Liang S, Fan W, Yang J
Advanced materials (Deerfield Beach, Fla.) 2024 May;36(19):e2308098
Advanced materials (Deerfield Beach, Fla.) 2024 May;36(19):e2308098
Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
Hu Y, Li Q, Qian Z, BeiXiao, Luo K, Luo N
Reproductive sciences (Thousand Oaks, Calif.) 2024 May;31(5):1311-1322
Reproductive sciences (Thousand Oaks, Calif.) 2024 May;31(5):1311-1322
miR-148a-3p regulates proliferation and apoptosis of idiopathic gingival fibroma by targeting NPTX1.
Sun Y, Xie L, Ren X, Ran L, He H, Kong F, Yang S, Zhang M
Oral diseases 2024 May;30(4):2136-2149
Oral diseases 2024 May;30(4):2136-2149
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Lan Y, Tian F, Tang H, Pu P, He Q, Duan L
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma.
Ren K, Ling X, Chen L, Li Z, Huang T
Journal of cellular and molecular medicine 2024 May;28(9):e18346
Journal of cellular and molecular medicine 2024 May;28(9):e18346
ARF6 promotes Streptococcus suis suilysin induced apoptosis in HBMECs.
Jiang C, Zhou P, Zhang X, Ma N, Hu Y, Zhang M, Ghonaim AH, Li H, Dong L, Zeng W, Li C, Lang Y, Sun Y, He Q, Li W
International journal of biological macromolecules 2024 May;268(Pt 2):131839
International journal of biological macromolecules 2024 May;268(Pt 2):131839
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Duan L, Hao Z, Ji R, Li X, Wang H, Su Y, Guan F, Ma S
International journal of biological macromolecules 2024 May;268(Pt 1):131739
International journal of biological macromolecules 2024 May;268(Pt 1):131739
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation.
Li X, Ji R, Duan L, Hao Z, Su Y, Wang H, Guan F, Ma S
International journal of biological macromolecules 2024 May;267(Pt 2):131520
International journal of biological macromolecules 2024 May;267(Pt 2):131520
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Yin HT, Hui-Lu, Yang JH, Li Q, Li M, Zhao QQ, Wen ZP
Biochemical pharmacology 2024 May;223:116113
Biochemical pharmacology 2024 May;223:116113
Heme oxygenase 1 (HO1) regulates autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway of yak Sertoli cells.
Yan Q, Wang Q, Nan J, Chen T, Wang J, Zhang Y, Yuan L
Theriogenology 2024 May;220:96-107
Theriogenology 2024 May;220:96-107
Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation.
Chu Y, Li Q, He Y, Li H, Wang Q, Li S, Wang J, Wang W, Ju S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114629
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114629
Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage.
Jiao B, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114594
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114594
Identification of MACC1 as a potential biomarker for pulmonary arterial hypertension based on bioinformatics and machine learning.
Zhou X, Liang B, Lin W, Zha L
Computers in biology and medicine 2024 May;173:108372
Computers in biology and medicine 2024 May;173:108372
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Wang J, Wang X, Chen F, Ning Q, Liu Y, Zhu Y, Wei W, Leng M, Wang Z, Jin P, Li Q
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways.
Pan G, Wu Y, Liu Y, Zhou F, Li S, Yang S
Journal of traditional and complementary medicine 2024 May;14(3):256-265
Journal of traditional and complementary medicine 2024 May;14(3):256-265
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Chen X, Wang B, Zhou Y, Wu X, Du A, Al Mamun A, Xu Y, Wang S, Jiang C, Xie L, Zhou K, Hu S, Xiao J
Advanced healthcare materials 2024 May;13(12):e2303462
Advanced healthcare materials 2024 May;13(12):e2303462
Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis.
Li W, Cao J, Zhang Y, Ling G, Tan N, Wei Y, Zhang Y, Wang X, Qian W, Jiang J, Zhang J, Wang W, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155473
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155473
Non-oxidized and oxidized flaxseed orbitides differently induce HepG2 cell apoptosis: involvement of cellular uptake and membrane death receptor DR4.
Peng C, Li J, Zhao A, Yu S, Zheng L, Deng ZY
Journal of the science of food and agriculture 2024 May;104(7):4296-4308
Journal of the science of food and agriculture 2024 May;104(7):4296-4308
Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma.
Zhang J, Shi X, Wang M, Zhai R, Wang M, Gong Z, Ni Z, Xu T, Zhu W, Liu L
Journal of cancer research and clinical oncology 2024 May 7;150(5):240
Journal of cancer research and clinical oncology 2024 May 7;150(5):240
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Jiang S, Ma F, Lou J, Li J, Shang X, Li Y, Wu J, Xu S
European journal of pharmacology 2024 May 5;970:176455
European journal of pharmacology 2024 May 5;970:176455
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo signaling pathway.
Wang L, Wang L, Wang R, Xu T, Wang J, Cui Z, Cheng F, Wang W, Yang X
Heliyon 2024 May 30;10(10):e31639
Heliyon 2024 May 30;10(10):e31639
Icariside I reduces breast cancer proliferation, apoptosis, invasion, and metastasis probably through inhibiting IL-6/STAT3 signaling pathway.
Hou M, Li H, He T, Hui S, Dai W, Hou X, Zhao J, Zhao J, Wen J, Kan W, Xiao X, Zhan X, Bai Z
The Journal of pharmacy and pharmacology 2024 May 3;76(5):499-513
The Journal of pharmacy and pharmacology 2024 May 3;76(5):499-513
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
Guo X, He L, Xu W, Wang W, Feng X, Fu Y, Zhang X, Ding RB, Qi X, Bao J, Luo S
Marine drugs 2024 May 29;22(6)
Marine drugs 2024 May 29;22(6)
miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia.
Liu J, Bao B, Li T, Yang Z, Du Y, Zhang R, Xin J, Hao J, Wang G, Bi H, Guo D
Journal of translational medicine 2024 May 28;22(1):511
Journal of translational medicine 2024 May 28;22(1):511
Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.
Yang L, Ruan Y, Chen B, Zhu Y, Xu H
Scientific reports 2024 May 28;14(1):12181
Scientific reports 2024 May 28;14(1):12181
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy.
Ding SA, Liu H, Zheng R, Ge Y, Fu Z, Mei J, Tang M
Cell biology and toxicology 2024 May 27;40(1):40
Cell biology and toxicology 2024 May 27;40(1):40
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Ge Y, Wu X, Cai Y, Hu Q, Wang J, Zhang S, Zhao B, Cui W, Wu Y, Wang Q, Feng T, Liu H, Qu Y, Ge S
Cell death & disease 2024 May 27;15(5):364
Cell death & disease 2024 May 27;15(5):364
Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway.
Wang JB, Du MW, Zheng Y
World journal of stem cells 2024 May 26;16(5):591-603
World journal of stem cells 2024 May 26;16(5):591-603
miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL.
Wang Z, Yin X, Yang P, Gong B, Liu H
Acta biochimica et biophysica Sinica 2024 May 25;56(5):675-687
Acta biochimica et biophysica Sinica 2024 May 25;56(5):675-687
Salvianolic acid A alleviates H(2)O(2)-induced endothelial oxidative injury via miR-204-5p.
Qiao X, Cao S, Chen S, Guo Y, Chen N, Zheng Y, Jin B
Scientific reports 2024 May 24;14(1):11931
Scientific reports 2024 May 24;14(1):11931
Rotenone activates the LKB1-AMPK-ULK1 signaling pathway to induce autophagy and apoptosis in rat thoracic aortic endothelial cells.
Chang X, Li Z, Tian M, Deng Z, Zhu L, Li G
BMC pharmacology & toxicology 2024 May 23;25(1):33
BMC pharmacology & toxicology 2024 May 23;25(1):33
Targeted Drug Therapy for Senescent Cells Alleviates Unilateral Ureteral Obstruction-Induced Renal Injury in Rats.
Li T, Yang K, Tong Y, Guo S, Gao W, Zou X
Pharmaceutics 2024 May 23;16(6)
Pharmaceutics 2024 May 23;16(6)
YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells.
Yu Y, Chu C, Wang K, Li Y, Mao Z, Hu L, Wang J, Yu Y, Sun H, Chen F
Respiratory research 2024 May 18;25(1):212
Respiratory research 2024 May 18;25(1):212
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma.
Zhao H, Meng L, Du P, Liao X, Mo X, Gong M, Chen J, Liao Y
Biological research 2024 May 17;57(1):30
Biological research 2024 May 17;57(1):30
Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways.
Wang T, Zhang M, Gong X, Chen W, Peng Y, Liao C, Xu H, Li Q, Shen G, Ren H, Zhu Y, Zhang B, Mao J, Wei L, Chen Y, Yang X
iScience 2024 May 17;27(5):109741
iScience 2024 May 17;27(5):109741
Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells.
Xu S, Li Z, Xin X, An F
Marine drugs 2024 May 17;22(5)
Marine drugs 2024 May 17;22(5)
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Cao Y, Luo Y, Wang L, Li R, Di H, Gu T, Cao Y, Zeng T, Zhu J, Chen L, An D, Ma Y, Xu W, Tian Y, Lu L
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Huang WT, Chen XJ, Lin YK, Shi JF, Li H, Wu HD, Jiang RL, Chen S, Wang X, Tan XX, Chen KY, Wang P
European journal of pharmacology 2024 May 15;971:176521
European journal of pharmacology 2024 May 15;971:176521
ADPN Regulates Oxidative Stress-Induced Follicular Atresia in Geese by Modulating Granulosa Cell Apoptosis and Autophagy.
Zheng Y, Qiu Y, Wang Q, Gao M, Cao Z, Luan X
International journal of molecular sciences 2024 May 15;25(10)
International journal of molecular sciences 2024 May 15;25(10)
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Yan Y, Bai S, Han H, Dai J, Niu L, Wang H, Dong Q, Yin H, Yuan G, Pan Y
Cell communication and signaling : CCS 2024 May 15;22(1):272
Cell communication and signaling : CCS 2024 May 15;22(1):272
Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure-Activity Relationship and Potential Target.
Zhang D, He X, Wang T, Xing Y, Xiu Z, Bao Y, Dong Y
Molecules (Basel, Switzerland) 2024 May 14;29(10)
Molecules (Basel, Switzerland) 2024 May 14;29(10)
Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology.
Liu Q, Luo Z, Sun M, Li W, Liu S
Aging 2024 May 13;16(9):7979-7999
Aging 2024 May 13;16(9):7979-7999
Efficacy and Safety of Asparagusic Acid against Echinococcus multilocularis In Vitro and in a Murine Infection Model.
Lu Z, Wang Y, Liu C, Fan H
Tropical medicine and infectious disease 2024 May 11;9(5)
Tropical medicine and infectious disease 2024 May 11;9(5)
PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells.
Liu Y, Gu F, Gao J, Gu Y, Li Z, Lu D, Zhang Y
Cell division 2024 May 11;19(1):18
Cell division 2024 May 11;19(1):18
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma.
Pan B, Cheng J, Tan W, Wu X, Fan Q, Fan L, Jiang M, Yu R, Cheng X, Deng Y
Aging 2024 May 10;16(9):8171-8197
Aging 2024 May 10;16(9):8171-8197
Esculin suppresses the PERK-eIF2α-CHOP pathway by enhancing SIRT1 expression in oxidative stress-induced rat chondrocytes, mitigating osteoarthritis progression in a rat model.
Cheng Z, Liu Z, Liu C, Yang A, Miao H, Bai X
International immunopharmacology 2024 May 10;132:112061
International immunopharmacology 2024 May 10;132:112061
Cadmium exacerbates liver injury by remodeling ceramide metabolism: Multiomics and laboratory evidence.
Xie D, Yan J, Zhang H, Zhang H, Nie G, Zhu X, Li X
The Science of the total environment 2024 May 1;923:171405
The Science of the total environment 2024 May 1;923:171405
A unique circ_0067716/EIF4A3 double-negative feedback loop impacts malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.
Zhao S, Xiao M, Li L, Zhang H, Shan M, Cui S, Zhang L, Zhang G, Wu S, Jin C, Yang J, Lu X
The Science of the total environment 2024 May 1;923:171349
The Science of the total environment 2024 May 1;923:171349
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Xiang K, Liu Y, Zhu R, Xu Y, Sun D, Yang Y, Yan Y, Yang B, Li H, Chen L
Food chemistry 2024 May 1;439:138136
Food chemistry 2024 May 1;439:138136
Betulinic acid inhibits the proliferation of human laryngeal carcinoma cells through reactive oxygen species-mediate mitochondrial apoptotic pathway.
Zhang H, Zhou M, Ye C, Qin J, Lu X, Wang C, Wang X, Jin X
Toxicology in vitro : an international journal published in association with BIBRA 2024 Mar;95:105756
Toxicology in vitro : an international journal published in association with BIBRA 2024 Mar;95:105756
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H
Archives of biochemistry and biophysics 2024 Mar;753:109892
Archives of biochemistry and biophysics 2024 Mar;753:109892
Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis.
Tan M, Mao J, Zheng J, Meng Y, Li J, Hao J, Shen H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Mar;73(3):415-432
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Mar;73(3):415-432
Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, Li Y, Tang H
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101063
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
Li Z, Zhang F, Huang L, Deng J, Pan Y, Xu T, Liu J, Gao N, Duan R, Shao C, Wu C, Wang M, Lu L
Neurochemical research 2024 Mar;49(3):670-683
Neurochemical research 2024 Mar;49(3):670-683
Minocycline attenuates the bilirubin-induced developmental neurotoxicity through the regulation of innate immunity and oxidative stress in zebrafish embryos.
Xiong G, Hu T, Yang Y, Zhang H, Han M, Wang J, Jing Y, Liu H, Liao X, Liu Y
Toxicology and applied pharmacology 2024 Mar;484:116859
Toxicology and applied pharmacology 2024 Mar;484:116859
Pterostilbene protects against H(2) O(2) -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Di W, Zhao A, Li X, Chen J, Dai Y, Li J, Lei W, Yang Y, Lu H
Cell biochemistry and function 2024 Mar;42(2):e3956
Cell biochemistry and function 2024 Mar;42(2):e3956
Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.
Peng S, Liang W, Liu Z, Ye S, Peng Z, Zhong Z, Ye Q
Human cell 2024 Mar;37(2):420-434
Human cell 2024 Mar;37(2):420-434
RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats.
Ni H, Kan X, Rui Q, Zhang Y, Zhai W, Zhang B, Yu Z
CNS neuroscience & therapeutics 2024 Mar;30(3):e14691
CNS neuroscience & therapeutics 2024 Mar;30(3):e14691
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Xu X, Li Y, Xu R, Meng Y, Li Z, Zuo D, Wu Y
The FEBS journal 2024 Mar;291(6):1199-1219
The FEBS journal 2024 Mar;291(6):1199-1219
Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Cao Y, Su H, Zeng J, Xie Y, Liu Z, Liu F, Qiu Y, Yi F, Lin J, Hammes HP, Zhang C
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50
Long noncoding RNA LINC00675 drives malignancy in acute myeloid leukemia via the miR-6809 -CDK6 axis.
Long X, Jiang H, Liu Z, Liu J, Hu R
Pathology, research and practice 2024 Mar;255:155221
Pathology, research and practice 2024 Mar;255:155221
Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart.
Lu T, Li D, Yuan X, Wang Z, Shao Z, Feng X, Yang C, Liu H, Zhang G, Wang Y, Liu X, Zhou L, Xu M
Cardiovascular toxicology 2024 Mar;24(3):291-301
Cardiovascular toxicology 2024 Mar;24(3):291-301
NCAPD2 promotes the malignant progression of oral squamous cell carcinoma via the Wnt/β-catenin pathway.
Ma P, Yu H, Zhu M, Liu L, Cheng L, Han Z, Jin W
Cell cycle (Georgetown, Tex.) 2024 Mar;23(5):588-601
Cell cycle (Georgetown, Tex.) 2024 Mar;23(5):588-601
Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice.
Liu Z, Sun M, Liu W, Feng F, Li X, Jin C, Zhang Y, Wang J
Biochemical pharmacology 2024 Mar;221:116033
Biochemical pharmacology 2024 Mar;221:116033
Homoharringtonine induces apoptosis of mammary carcinoma cells by inhibiting the AKT/mTOR signaling pathway.
Zhang X, Mei C, Liang Z, Zhi Y, Xu H, Wang H, Dong H
Veterinary and comparative oncology 2024 Mar;22(1):57-69
Veterinary and comparative oncology 2024 Mar;22(1):57-69
Golden bifid treatment regulates gut microbiota and serum metabolites to improve myocardial dysfunction in cecal ligation and puncture-induced sepsis mice.
Wu R, Xu J, Zeng H, Fan Y, Li H, Peng T, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167049
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167049
Ramelteon alleviates myocardial ischemia/reperfusion injury (MIRI) through Sirt3--dependent regulation of cardiomyocyte apoptosis.
Yang Z, Xie Y, Li M, Chen W, Zhong C, Ju J, Deng Q, Wang H, Cheng T, Zhang L, Du W, Liang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116229
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116229
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury.
Xiao T, Wei J, Cai D, Wang Y, Cui Z, Chen Q, Gu Q, Zou A, Mao L, Chi B, Ji Y, Wang Q, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116224
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116224
Synthesis, antitumor activity evaluation of 2-selenocyano-3-selenocyanoalkyloxyestradiols with a bisselenocyanate structure.
Huang Y, Cheng Y, Wei M, Peng Z, Tian W, Liu Z, Li J, Cui J
Bioorganic chemistry 2024 Mar;144:107149
Bioorganic chemistry 2024 Mar;144:107149
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer.
Shi MY, Wang Y, Shi Y, Tian R, Chen X, Zhang H, Wang K, Chen Z, Chen R
Genes & diseases 2024 Mar;11(2):978-992
Genes & diseases 2024 Mar;11(2):978-992
Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration.
Peng Y, Chen X, Zhang Q, Liu S, Wu W, Li K, Lin H, Qing X, Xiao Y, Wang B, Quan D, Feng S, Rao Z, Bai Y, Shao Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2304761
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2304761
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Chen X, Xiang W, Li L, Xu K
International journal of toxicology 2024 Mar-Apr;43(2):134-145
International journal of toxicology 2024 Mar-Apr;43(2):134-145
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke.
Xie J, Zhang Y, Li B, Xi W, Wang Y, Li L, Liu C, Shen L, Han B, Kong Y, Yao H, Zhang Z
Journal of translational medicine 2024 Mar 7;22(1):248
Journal of translational medicine 2024 Mar 7;22(1):248
Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma.
Zhang F, Chen J, Luo W, Wen C, Mao W, Yang Y, Liu C, Xu Y, Chen W, Wen L
International journal of pharmaceutics 2024 Mar 5;652:123865
International journal of pharmaceutics 2024 Mar 5;652:123865
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Wang X, Liu Z, Deng S, Zhou J, Li X, Huang J, Chen J, Ji C, Deng Y, Hu Y
International immunopharmacology 2024 Mar 30;130:111755
International immunopharmacology 2024 Mar 30;130:111755
Combined metabolomic and proteomic analysis of sepsis related acute liver injury and its pathogenesis research.
Zhang J, Wang X, Peng Y, Wei J, Luo Y, Luan F, Li H, Zhou Y, Wang C, Yu K
International immunopharmacology 2024 Mar 30;130:111666
International immunopharmacology 2024 Mar 30;130:111666
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice.
He DW, Liu DZ, Luo XZ, Chen CB, Lu CH, Na N, Huang F
Biological chemistry 2024 Mar 25;405(3):167-176
Biological chemistry 2024 Mar 25;405(3):167-176
Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin.
Li Z, Zhu H, Liu H, Liu D, Liu J, Zhang Y, Qin Z, Xu Y, Peng Y, Ruan L, Li J, He Y, Liu B, Long Y
Journal of nanobiotechnology 2024 Mar 25;22(1):129
Journal of nanobiotechnology 2024 Mar 25;22(1):129
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Li XY, Yin X, Lu JJ, Li QR, Xing WQ, Han Q, Ji H, Li SZ, Yang HM, Guo JR, Wang ZQ, Xu B
Cells 2024 Mar 25;13(7)
Cells 2024 Mar 25;13(7)
Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.
Luo Y, Chang T, Huang S, Xiang J, Tang S, Shen H
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)
Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia.
Li F, Miao J, Liu R, Zhang R, He A
Journal of cancer research and clinical oncology 2024 Mar 20;150(3):144
Journal of cancer research and clinical oncology 2024 Mar 20;150(3):144
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.
Chen G, Li X, Zhou X, Li Y, Yu H, Peng X, Bai X, Zhang C, Feng Z, Mei Y, Li L, Liu Y, Gou X, Jiang Y
Scientific reports 2024 Mar 20;14(1):6720
Scientific reports 2024 Mar 20;14(1):6720
Pan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis.
Wang ZQ, Wu ZX, Wang ZP, Bao JX, Wu HD, Xu DY, Li HF, Xu YY, Wu RX, Dai XX
BMC cancer 2024 Mar 19;24(1):353
BMC cancer 2024 Mar 19;24(1):353
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Xin X, Liu J, Liu X, Xin Y, Hou Y, Xiang X, Deng Y, Yang B, Yu W
ACS nano 2024 Mar 19;18(11):8307-8324
ACS nano 2024 Mar 19;18(11):8307-8324
Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
Huang Y, Wu Z, Peng Z, Liu A, Yuan W, Han D, Peng J
BMC cancer 2024 Mar 18;24(1):345
BMC cancer 2024 Mar 18;24(1):345
The effect of selenium on the proliferation of bovine endometrial epithelial cells in a lipopolysaccharide-induced damage model.
Li H, Wang H, Cui L, Liu K, Guo L, Li J, Dong J
BMC veterinary research 2024 Mar 18;20(1):109
BMC veterinary research 2024 Mar 18;20(1):109
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway.
Zhang Z, Zhang Q, Liu Z, Wang C, Chen H, Luo X, Shen L, Long C, Wei G, Liu X
Experimental cell research 2024 Mar 15;436(2):113980
Experimental cell research 2024 Mar 15;436(2):113980
Metformin switches cell death modes to soothe the apical periodontitis via ZBP1.
Liu H, Liu YX, Fan W, Fan B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23549
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23549
IL-13 alleviates acute kidney injury and promotes regeneration via activating the JAK-STAT signaling pathway in a rat kidney transplantation model.
Yu C, Zhang J, Pei J, Luo J, Hong Y, Tian X, Liu Z, Zhu C, Long C, Shen L, He X, Wen S, Liu X, Wu S, Hua Y, Wei G
Life sciences 2024 Mar 15;341:122476
Life sciences 2024 Mar 15;341:122476
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
Wang W, Zhou C, Ma Z, Zeng L, Wang H, Cheng X, Zhang C, Xue Y, Yuan Y, Li J, Hu L, Huang J, Luo T, Zheng L
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.
Wang R, Cheng F, Yang X
Journal of ovarian research 2024 Mar 15;17(1):62
Journal of ovarian research 2024 Mar 15;17(1):62
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells.
Zhang JW, Huang LY, Li YN, Tian Y, Yu J, Wang XF
World journal of gastrointestinal oncology 2024 Mar 15;16(3):991-1005
World journal of gastrointestinal oncology 2024 Mar 15;16(3):991-1005
Trilobolide-6-O-isobutyrate exerts anti-tumor effects on cholangiocarcinoma cells through inhibiting JAK/STAT3 signaling pathway.
Zhang HX, Fan R, Chen QE, Zhang LJ, Hui Y, Xu P, Li SY, Chen GY, Chen WH, Shen DY
Heliyon 2024 Mar 15;10(5):e27217
Heliyon 2024 Mar 15;10(5):e27217
Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis.
Ou QL, Cheng L, Chang YL, Liu JH, Zhang SF
Heliyon 2024 Mar 15;10(5):e27082
Heliyon 2024 Mar 15;10(5):e27082
Network pharmacology prediction, molecular docking and in vitro experiment explored the potential mechanism of Gaoyuan'an capsule in improving hypoxia tolerance.
Jin T, Liu X, Wang Y, Qi Y, Li X, Wang L, He X
The pharmacogenomics journal 2024 Mar 14;24(2):8
The pharmacogenomics journal 2024 Mar 14;24(2):8
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Cen Q, Chen J, Guo J, Chen M, Wang H, Wu S, Zhang H, Xie X, Li Y
Journal of translational medicine 2024 Mar 14;22(1):278
Journal of translational medicine 2024 Mar 14;22(1):278
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling.
Zhao L, Yang H, Li M, Xiao M, Li X, Cheng L, Cheng W, Chen M, Zhao Y
Journal of animal science and biotechnology 2024 Mar 14;15(1):47
Journal of animal science and biotechnology 2024 Mar 14;15(1):47
Effects of Dityrosine on Lactic Acid Metabolism in Mice Gastrocnemius Muscle During Endurance Exercise via the Oxidative Stress-Induced Mitochondria Damage.
Xia Q, Lan J, Pan Y, Wang Y, Song T, Yang Y, Tian X, Chen L, Gu Z, Ding YY
Journal of agricultural and food chemistry 2024 Mar 13;72(10):5269-5282
Journal of agricultural and food chemistry 2024 Mar 13;72(10):5269-5282
Red fluorescent BODIPY-based nanoparticles for targeted cancer imaging-guided photodynamic therapy.
Kim C, Mai DK, Kim WJ, Badon IW, Jo J, Kang D, Kim SJ, Kim HJ, Yang J
Biomaterials science 2024 Mar 12;12(6):1536-1548
Biomaterials science 2024 Mar 12;12(6):1536-1548
ATP5me alleviates high glucose-induced myocardial cell injury.
Hou Q, Yan F, Li X, Liu H, Yang X, Dong X
International immunopharmacology 2024 Mar 10;129:111626
International immunopharmacology 2024 Mar 10;129:111626
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity.
Wang X, Zhang F, Niu L, Yan J, Liu H, Wang D, Hui J, Dai H, Song J, Zhang Z
Journal of affective disorders 2024 Mar 1;348:265-274
Journal of affective disorders 2024 Mar 1;348:265-274
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
An oxidized dextran-composite self-healing coated magnesium scaffold reduces apoptosis to induce bone regeneration.
Shi Z, Yang F, Hu Y, Pang Q, Shi L, Du T, Cao Y, Song B, Yu X, Cao Z, Ye Z, Liu C, Yu R, Chen X, Zhu Y, Pang Q
Carbohydrate polymers 2024 Mar 1;327:121666
Carbohydrate polymers 2024 Mar 1;327:121666
Jiangqi Pingxiao formula regulates dendritic cell apoptosis in an autophagy-dependent manner through the AMPK/mTOR pathway in a murine model of OVA-induced asthma.
Shan Y, Wu J, Dai X, Yuan C, Jiang J, Yan H, Tang L, Dong Y, Ren L, Pan Q, Ji J, Zhao X
Journal of ethnopharmacology 2024 Mar 1;321:117405
Journal of ethnopharmacology 2024 Mar 1;321:117405
Effects of gas signaling molecule SO(2) in cardiac functions of hyperthyroid rats.
Yang Q, Yang T, Liu X, Liu S, Liu W, Nie L, Chu C, Yang J
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2024 Mar 1;28(2):129-143
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2024 Mar 1;28(2):129-143
The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis.
Tian K, Zheng L, Yuan T, Chen X, Chen Q, Xue X, Huang S, He W, Jin M, Zhang Y
Cancer cell international 2024 Mar 1;24(1):91
Cancer cell international 2024 Mar 1;24(1):91
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
Li D, Zhou L, Liu Z, Zhang Z, Mao W, Shi W, Zhu M, Wang F, Wan Y
Theriogenology 2024 Mar 1;216:20-29
Theriogenology 2024 Mar 1;216:20-29
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.
Zhou C, Li D, He J, Luo T, Liu Y, Xue Y, Huang J, Zheng L, Li J
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)
DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
Li M, Wu X, Chen M, Hao S, Yu Y, Li X, Zhao E, Xu M, Yu Z, Wang Z, Xu N, Jin C, Yin Y
Haematologica 2024 Mar 1;109(3):751-764
Haematologica 2024 Mar 1;109(3):751-764
SEP-363856 exerts neuroprotection through the PI3K/AKT/GSK-3β signaling pathway in a dual-hit neurodevelopmental model of schizophrenia-like mice.
Li M, Liu Y, Sun M, Yang Y, Zhang L, Liu Y, Li F, Liu H
Drug development research 2024 Jun;85(4):e22225
Drug development research 2024 Jun;85(4):e22225
Beneficial effects of human umbilical cord mesenchymal stem cell (HUCMSC) transplantation on cyclophosphamide (CTX)-induced premature ovarian failure (POF) in Tibetan miniature pigs.
Cai J, Liang X, Sun Y, Bao S
Transplant immunology 2024 Jun;84:102051
Transplant immunology 2024 Jun;84:102051
GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis.
Zhou T, Zhang L, He L, Lan Y, Ding L, Li L, Wang Z
Molecular neurobiology 2024 Jun;61(6):3369-3383
Molecular neurobiology 2024 Jun;61(6):3369-3383
RGS2 attenuates alveolar macrophage damage by inhibiting the Gq/11-Ca(2+) pathway during cowshed PM2.5 exposure, and aberrant RGS2 expression is associated with TLR2/4 activation.
Ma Z, Du X, Sun Y, Sun K, Zhang X, Wang L, Zhu Y, Basang W, Gao Y
Toxicology and applied pharmacology 2024 Jun;487:116976
Toxicology and applied pharmacology 2024 Jun;487:116976
Dual-specificity phosphatase 26 protects against kidney injury caused by ischaemia-reperfusion through restraint of TAK1-JNK/p38-mediated apoptosis and inflammation of renal tubular epithelial cells.
Xiang H, Li Z, Li Y, Zheng J, Dou M, Xue W, Wu X
Toxicology and applied pharmacology 2024 Jun;487:116954
Toxicology and applied pharmacology 2024 Jun;487:116954
Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression.
An X, Wu W, Wang P, Mahmut A, Guo J, Dong J, Gong W, Liu B, Yang L, Ma Y, Xu X, Chen J, Cao W, Jiang Q
Biomedical journal 2024 Jun;47(3):100651
Biomedical journal 2024 Jun;47(3):100651
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Yan X, Li Z, Chen H, Yang F, Tian Q, Zhang Y
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Chen L, Duan F, Ge F, Tian L, Li Y, Li Y, Zhu Q, Zhou Q, Lin H
Metabolic brain disease 2024 Jun;39(5):871-884
Metabolic brain disease 2024 Jun;39(5):871-884
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Exosomes Derived from Mesenchymal Stem Cells Increase the Viability of Damaged Endometrial Cells via the miR-99b-5p/PCSK9 Axis.
Li L, An J, Wang Y, Liu L, Wang Y, Zhang X
Stem cells and development 2024 Jun;33(11-12):290-305
Stem cells and development 2024 Jun;33(11-12):290-305
Menstrual Blood-Derived Endometrial Stem Cell Transplantation Improves Male Reproductive Dysfunction in T1D Mice by Enhancing Antioxidative Capacity.
Lu Y, Liu R, Kang X, Zhang S, Sun Y, Fan W, Cheng H, Liu Y, Lin J
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jun;31(6):1719-1731
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jun;31(6):1719-1731
Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Li J, Mo JR, Hu SY, Dong X, Li JW, Yang LY, Wu YJ
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis.
Xie J, Yan J, Ji K, Guo Y, Xu S, Shen D, Li C, Gao H, Zhao L
International journal of biological macromolecules 2024 Jun;271(Pt 2):132667
International journal of biological macromolecules 2024 Jun;271(Pt 2):132667
Structural characterization and improves cognitive disorder in ageing mice of a glucomannan from Dendrobium huoshanense.
Zhang X, Ge R, Wu J, Cai X, Deng G, Lv J, Ma M, Yu N, Yao L, Peng D
International journal of biological macromolecules 2024 Jun;269(Pt 1):131995
International journal of biological macromolecules 2024 Jun;269(Pt 1):131995
A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis.
Hong J, Li Y, Chen L, Han D, Li Y, Mi X, Liu K, Wang Q, Song Y, Liu T, Yang N, Liu Y, Li Z, Guo X
Biochemical pharmacology 2024 Jun;224:116261
Biochemical pharmacology 2024 Jun;224:116261
The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels.
Li H, Yuan C, Wang H, Cui L, Liu K, Guo L, Li J, Dong J
Biological trace element research 2024 Jun;202(6):2564-2576
Biological trace element research 2024 Jun;202(6):2564-2576
POSTN knockdown suppresses IL-1β-induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF-κB pathway and alleviates intervertebral disc degeneration.
Wang Z, Zhu D, Yang F, Chen H, Kang J, Liu W, Lin A, Kang X
Journal of cell communication and signaling 2024 Jun;18(2):e12030
Journal of cell communication and signaling 2024 Jun;18(2):e12030
12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.
Yang C, Xing S, Wei X, Lu J, Zhao G, Ma X, Dai Z, Liang X, Huang W, Liu Y, Jiang X, Zhu D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116736
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116736
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation.
Wang H, Chen L, Zhang R, Zhang G, Liu J, Guo F
Fitoterapia 2024 Jun;175:105957
Fitoterapia 2024 Jun;175:105957
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
Zhang T, Wang X, Wang D, Lei M, Hu Y, Chen Z, Li Y, Luo Y, Zhang L, Zhu Y
Biomaterials advances 2024 Jun;160:213859
Biomaterials advances 2024 Jun;160:213859
13-Oxyingenol-dodecanoate inhibits the growth of non-small cell lung cancer cells by targeting ULK1.
Wang XY, Wang YJ, Guo BW, Hou ZL, Zhang GX, Han Z, Liu Q, Yao GD, Song SJ
Bioorganic chemistry 2024 Jun;147:107367
Bioorganic chemistry 2024 Jun;147:107367
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.
Villareal LB, Falcon DM, Xie L, Xue X
British journal of cancer 2024 Jun;130(12):1904-1915
British journal of cancer 2024 Jun;130(12):1904-1915
Neobractatin induces pyroptosis of esophageal cancer cells by TOM20/BAX signaling pathway.
Li Z, Bao Z, Tan J, Chen G, Ye B, Zhao J, Zhang L, Xu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155547
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155547
The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy.
Duan H, Yang S, Yang S, Zeng J, Yan Z, Zhang L, Ma X, Dong W, Zhang Y, Zhao X, Hu J, Xiao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155468
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155468
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Tao X, Pan X, Zhao G, Xue M, Rui Y
Food science & nutrition 2024 Jun;12(6):3893-3909
Food science & nutrition 2024 Jun;12(6):3893-3909
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Wang Y, Wang S, Wang Y, Wang C, Tang Y, Zhang C, Hou S, Yu D, Lin N
Cellular signalling 2024 Jun;118:111137
Cellular signalling 2024 Jun;118:111137
Melatonin alleviates endoplasmic reticulum stress and follicular granulosa cell apoptosis by regulating ATF4 to activate mTOR signaling pathway in chickens.
Hao EY, Liu XL, Chen XY, Xue H, Su BF, Chen YF, Wang DH, Shi L, Bai K, Hou F, Hou JK, Bao HL, Chen H
Poultry science 2024 Jun;103(6):103656
Poultry science 2024 Jun;103(6):103656
Mechanistic study of heat shock protein 60-mediated apoptosis in DF-1 cells.
Li Y, Cao S, Li Y
Poultry science 2024 Jun;103(6):103619
Poultry science 2024 Jun;103(6):103619
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Hu Y, Hao R, Li D, Lu Y, Yu G
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling.
Zhu W, Wu C, Liu Z, Zhao S, Cheng X, Huang J
Cancer cell international 2024 Jun 6;24(1):201
Cancer cell international 2024 Jun 6;24(1):201
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553
European journal of pharmacology 2024 Jun 5;972:176553
Medicinal cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway.
Shen B, Wang Z, Yu H, Shen X, Li L, Ru Y, Yang C, Du G, Lai C, Gao Y
Behavioural brain research 2024 Jun 5;467:115005
Behavioural brain research 2024 Jun 5;467:115005
Icariin improves oxidative stress injury during ischemic stroke via inhibiting mPTP opening.
Zhou Z, Li W, Ni L, Wang T, Huang Y, Yu Y, Hu M, Liu Y, Wang J, Huang X, Wang Y
Molecular medicine (Cambridge, Mass.) 2024 Jun 5;30(1):77
Molecular medicine (Cambridge, Mass.) 2024 Jun 5;30(1):77
Hypoxia-inducible factor prolyl hydroxylase inhibitor alleviates heatstroke-induced acute kidney injury by activating BNIP3-mediated mitophagy.
Wang L, Song Y, Zhang P, Chen W, Xiao F, Zhou P, Yang X, Dai H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23723
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23723
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Ding SM, Shi LG, Cao ZP, Zhu NN, Liu YY, Wang MY, Cui SS, Cheng HR, Liang D, Cao YX, Liu YJ
Heliyon 2024 Jun 30;10(12):e33132
Heliyon 2024 Jun 30;10(12):e33132
Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway.
Li Y, Tian M, Pires Sanches JG, Zhang Q, Hou L, Zhang J
International journal of molecular sciences 2024 Jun 29;25(13)
International journal of molecular sciences 2024 Jun 29;25(13)
Thonzonium bromide inhibits progression of malignant pleural mesothelioma through regulation of ERK1/2 and p38 pathways and mitochondrial uncoupling.
Dell'Anno I, Morani F, Patergnani S, Daga A, Pinton P, Giorgi C, Mutti L, Gemignani F, Landi S
Cancer cell international 2024 Jun 29;24(1):226
Cancer cell international 2024 Jun 29;24(1):226
WZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis.
Yan T, Jiang Q, Ni G, Ma H, Meng Y, Kang G, Xu M, Peng F, Li H, Chen X, Wang M
Cancer cell international 2024 Jun 27;24(1):221
Cancer cell international 2024 Jun 27;24(1):221
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Wang Q, Li A, Yu H, Wang C, Wang T, Zhang J
International journal of molecular sciences 2024 Jun 26;25(13)
International journal of molecular sciences 2024 Jun 26;25(13)
Lumbrokinase Extracted from Earthworms Synergizes with Bevacizumab and Chemotherapeutics in Treating Non-Small Cell Lung Cancer by Targeted Inactivation of BPTF/VEGF and NF-κB/COX-2 Signaling.
Hua C, Guo Z, Dai M, Zhou J, Ge H, Xue G, Xu F, Ru L, Lv K, Zhang G, Zheng L, Wang M, Teng Y, Yu W, Guo W
Biomolecules 2024 Jun 23;14(7)
Biomolecules 2024 Jun 23;14(7)
Topiramate suppresses peri-infarct spreading depolarization and improves outcomes in a rat model of photothrombotic stroke.
Wang Y, Yen S, Ian Shih YY, Lai CW, Chen YL, Chen LT, Chen H, Liao LD
iScience 2024 Jun 21;27(6):110033
iScience 2024 Jun 21;27(6):110033
Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway.
Xi C, Zhang G, Sun N, Liu M, Ju N, Shen C, Song H, Luo Q, Qiu Z
iScience 2024 Jun 21;27(6):109829
iScience 2024 Jun 21;27(6):109829
Network pharmacology and biochemical experiments reveal the antiapoptotic mechanism of huperzine A for treating diabetic retinopathy.
Zhang Y, Huang W, Tian Q, Bai G, Wu W, Yin H, Hu L, Chen X
The British journal of ophthalmology 2024 Jun 20;108(7):989-998
The British journal of ophthalmology 2024 Jun 20;108(7):989-998
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Zou S, Wu Y, Wen M, Liu J, Chen M, Yuan J, Zhou B
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma.
Liu M, Bai R, Zhang G, Liu X, Wang Z, He K, Gan X, Zhou X, Yin P, Zheng Y, Wang G
Scientific reports 2024 Jun 19;14(1):14113
Scientific reports 2024 Jun 19;14(1):14113
Association of mitochondrial phosphoenolpyruvate carboxykinase with prognosis and immune regulation in hepatocellular carcinoma.
Li C, Zhang ED, Ye Y, Xiao Z, Huang H, Zeng Z
Scientific reports 2024 Jun 18;14(1):14051
Scientific reports 2024 Jun 18;14(1):14051
Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice.
Du L, Chen C, Yang YH, Zheng Y, Li H, Wu ZJ, Wu H, Miyashita K, Su GH
Food & function 2024 Jun 17;15(12):6359-6373
Food & function 2024 Jun 17;15(12):6359-6373
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Feng X, Zheng Y, Mao N, Shen M, Chu L, Fang Y, Pang M, Wang Z, Lin Z
International immunopharmacology 2024 Jun 15;134:112257
International immunopharmacology 2024 Jun 15;134:112257
Bradykinin protects nucleus pulposus cells from tert-butyl hydroperoxide-induced damage and delays intervertebral disc degeneration.
Qiu X, Ma C, Luo Z, Zhang Y, Kang J, Zhu D, Wang Z, Li L, Wei Z, Wang Z, Kang X
International immunopharmacology 2024 Jun 15;134:112161
International immunopharmacology 2024 Jun 15;134:112161
SIAH2 is specifically expressed during cervical carcinogenesis, and closely relates to the abnormal proliferation of cervical epithelial cells.
Jing LP, Li M, Xia XY, Zheng X, Chen JY, He J, Zhuang XW
Heliyon 2024 Jun 15;10(11):e31487
Heliyon 2024 Jun 15;10(11):e31487
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
Yang F, Duan Y, Li Y, Zhu D, Wang Z, Luo Z, Zhang Y, Zhang G, He X, Kang X
Molecular medicine (Cambridge, Mass.) 2024 Jun 14;30(1):87
Molecular medicine (Cambridge, Mass.) 2024 Jun 14;30(1):87
Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy.
Bai J, Feng Z, Chen Y, Li Y, Zhang L, Li L
Discover oncology 2024 Jun 10;15(1):217
Discover oncology 2024 Jun 10;15(1):217
Intestinal microbiota via NLRP3 inflammasome dependent neuronal pyroptosis mediates anxiety-like behaviour in mice exposed to 3.5 GHz radiofrequency radiation.
Zhou GQ, Wang X, Gao P, Qin TZ, Guo L, Zhang ZW, Huang ZF, Lin JJ, Jing YT, Wang HN, Wang CP, Ding GR
The Science of the total environment 2024 Jun 1;927:172391
The Science of the total environment 2024 Jun 1;927:172391
Stereo-selective cardiac toxicity induced by metconazole via oxidative stress and the wnt/β-catenin signaling pathway in zebrafish embryos.
Liu L, Wang F, Zhang Z, Fan B, Luo Y, Li L, Zhang Y, Yan Z, Kong Z, Francis F, Li M
Environmental pollution (Barking, Essex : 1987) 2024 Jun 1;350:124034
Environmental pollution (Barking, Essex : 1987) 2024 Jun 1;350:124034
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Su W, Guo Y, Wang Q, Ma L, Zhang Q, Zhang Y, Geng Y, Jin T, Guo J, Yang R, Niu Z, Ren L, Wang Y, Ning Z, Li W, He W, Sun J, Li T, Li Z, Shan H, Liang H
Experimental & molecular medicine 2024 Jul;56(7):1643-1654
Experimental & molecular medicine 2024 Jul;56(7):1643-1654
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Fang Z, Lu M, Huang R, Wang G, Yushanjiang F, Jiang X, Li J
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function.
Cheng W, Wei B, Liu W, Jin L, Guo S, Ding M, Liu Y, Fan H, Li R, Zhang X, He X, Li X, Duan C
Experimental neurology 2024 Jul;377:114778
Experimental neurology 2024 Jul;377:114778
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Guo L, Li K, Ma Y, Niu H, Li J, Shao X, Li N, Sun Y, Wang H
Human cell 2024 Jul;37(4):972-985
Human cell 2024 Jul;37(4):972-985
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke.
Liu Y, Leng C, Li Y, Zhou M, Ye X, Li C, Xia X, Sun B, Shu X, Liu W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Jul;33(7):107736
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Jul;33(7):107736
GPX7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by IL‑1β, via a mechanism mediated by ferroptosis.
Chen B, Fu W, Jie C, Zhang G, Li Z, Liu Y, Zhou S
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
Overexpressed FKBP5 mediates colorectal cancer progression and sensitivity to FK506 treatment via the NF-κB signaling pathway.
Liu T, Wang C, Xia Z
The FEBS journal 2024 Jul;291(14):3128-3146
The FEBS journal 2024 Jul;291(14):3128-3146
Therapeutic potential of vitamin D3 in mitigating high glucose‑induced renal damage: Mechanistic insights into oxidative stress inhibition and TXNIP/NLRP3 signaling pathway blockade.
Li G, He S, Liu T, Zheng N
Experimental and therapeutic medicine 2024 Jul;28(1):277
Experimental and therapeutic medicine 2024 Jul;28(1):277
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis.
Zhao Y, Chen Y, Liu Z, Zhou L, Huang J, Luo X, Luo Y, Li J, Lin Y, Lai J, Liu J
Free radical biology & medicine 2024 Jul;219:1-16
Free radical biology & medicine 2024 Jul;219:1-16
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
Yan M, Su L, Wu K, Mei Y, Liu Z, Chen Y, Zeng W, Xiao Y, Zhang J, Cai G, Bai Y
Pharmacological research 2024 Jul;205:107235
Pharmacological research 2024 Jul;205:107235
Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice.
Wang Y, Liu Y, Xie Y, Luan J, Liu R, Zhu Y, Ma Y, Fan Y, Sun Y, Shang W, Han F
Journal of otology 2024 Jul;19(3):133-139
Journal of otology 2024 Jul;19(3):133-139
Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice.
Wu Y, Zhang H, Wang Y, Zhang Y, Hong Z, Wang D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116869
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116869
Estradiol contributes to sex differences in resilience to sepsis-induced metabolic dysregulation and dysfunction in the heart via GPER-1-mediated PPARδ/NLRP3 signaling.
Adu-Amankwaah J, Adekunle AO, Tang Z, Bushi A, Tan R, Fu L, Gong Z, Ma Z, Mprah R, Ndzie Noah ML, Wowui PI, Ong'achwa Machuki J, Pan X, Li T, Sun H
Metabolism: clinical and experimental 2024 Jul;156:155934
Metabolism: clinical and experimental 2024 Jul;156:155934
The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows.
Hu L, Fang H, Abbas Z, Luo H, Brito LF, Wang Y, Xu Q
Journal of dairy science 2024 Jul;107(7):5132-5149
Journal of dairy science 2024 Jul;107(7):5132-5149
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation.
Liu Y, Ji T, Jiang H, Chen M, Liu W, Zhang Z, He X
Journal of inflammation (London, England) 2024 Jul 9;21(1):25
Journal of inflammation (London, England) 2024 Jul 9;21(1):25
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
Zhang H, Han B, Tian S, Gong Y, Chen L, Liu L
Aging 2024 Jul 9;16(13):11103-11116
Aging 2024 Jul 9;16(13):11103-11116
FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells.
Pan Z, Ke C, Zheng H, Guo X, Gao W, Huang X, Chen C, Xiong Y, Zheng S, Zheng F, Hu W
Journal of cancer research and clinical oncology 2024 Jul 8;150(7):338
Journal of cancer research and clinical oncology 2024 Jul 8;150(7):338
Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction.
Wang Q, Ge L, Guo J, Zhang H, Chen T, Lian F, Li L, Xu Y, Xu J, Chen N, Zhang Y, Ruan Z, Xiao J, Zhang H, Yang L
ACS biomaterials science & engineering 2024 Jul 8;10(7):4480-4495
ACS biomaterials science & engineering 2024 Jul 8;10(7):4480-4495
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Su S, Liu L, Fu Q, Ma M, Yang N, Pan T, Geng S, Yu XF, Zhu J
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Eurochevalierines A-I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5.
Zhang Y, Li Q, Zhang J, Chen M, Li X, Qiao Y, Wang K, Qi C, Zhang Y
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16801-16811
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16801-16811
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
Xi H, Wang Z, Li M, Duan X, Li Y
International journal of molecular sciences 2024 Jul 30;25(15)
International journal of molecular sciences 2024 Jul 30;25(15)
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
Zhang R, Wen Y, Liu J, Hao J, Peng Y, Zhang M, Xie Y, Yang Z, Yin X, Shi Y, Bi H, Guo D
Journal of translational medicine 2024 Jul 30;22(1):710
Journal of translational medicine 2024 Jul 30;22(1):710
Quercetin attenuated ropivacaine-induced neurotoxicity in SH-SY5Y cells through upregulating Pim1 and enhancing autophagy.
Liu Y, Ren L, Sun Y, Yan J, Gong G
Heliyon 2024 Jul 30;10(14):e33829
Heliyon 2024 Jul 30;10(14):e33829
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Hu M, Hu L, Yang T, Zhou B, Feng X, Fan Z, Shan Z
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Deciphering the Effects of the PYCR Family on Cell Function, Prognostic Value, Immune Infiltration in ccRCC and Pan-Cancer.
Chen H, Chen Q, Chen J, Mao Y, Duan L, Ye D, Cheng W, Chen J, Gao X, Lin R, Lin W, Zhang M, Qi Y
International journal of molecular sciences 2024 Jul 25;25(15)
International journal of molecular sciences 2024 Jul 25;25(15)
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model.
Fang B, Yang T, Chen Y, Duan Z, Hu J, Wang Q, He Y, Zhang Y, Dong W, Zhang Q, Zhao X
Biomolecules 2024 Jul 25;14(8)
Biomolecules 2024 Jul 25;14(8)
Gut-derived metabolite 3-methylxanthine enhances cisplatin-induced apoptosis via dopamine receptor D1 in a mouse model of ovarian cancer.
Mai Z, Han Y, Liang D, Mai F, Zheng H, Li P, Li Y, Ma C, Chen Y, Li W, Zhang S, Feng Y, Chen X, Wang Y
mSystems 2024 Jul 23;9(7):e0130123
mSystems 2024 Jul 23;9(7):e0130123
Enhanced therapeutic impact of Shikonin-encapsulated exosomes in the inhibition of colorectal cancer progression.
Lu Y, Zhou H, Han C, Gong Y, Li Y, Xia Y, Liang B, Yang H, Wang Z
Nanotechnology 2024 Jul 23;35(41)
Nanotechnology 2024 Jul 23;35(41)
Hypoxia-enhanced YAP1-EIF4A3 interaction drives circ_0007386 circularization by competing with CRIM1 pre-mRNA linear splicing and promotes non-small cell lung cancer progression.
Li L, Liu D, Chen T, Wei C, Qiao Y, Liu W, Liang Y, Liang Z, Chen C, Li D, Wu B, Zhao X, Huang D, Wu D
Journal of experimental & clinical cancer research : CR 2024 Jul 20;43(1):200
Journal of experimental & clinical cancer research : CR 2024 Jul 20;43(1):200
Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
Shao M, Qiu Y, Shen M, Liu W, Feng D, Luo Z, Zhou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23749
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23749
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T
Journal of ethnopharmacology 2024 Jul 15;329:118107
Journal of ethnopharmacology 2024 Jul 15;329:118107
Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.
Zhao X, Fan C, Qie T, Fu X, Chen X, Wang Y, Wu Y, Fu X, Shi K, Yan W, Yu H
Reproductive biology and endocrinology : RB&E 2024 Jul 15;22(1):82
Reproductive biology and endocrinology : RB&E 2024 Jul 15;22(1):82
PRAME promotes proliferation of multiple myeloma cells through CTMP/Akt/p21/CCND3 axis by ubiquitinating CTMP and p21.
Sun K, Yang L, Wang F, Liu Y, Xu N, Shi ZY, Chen WM, Li K, Qin YZ
Heliyon 2024 Jul 15;10(13):e34094
Heliyon 2024 Jul 15;10(13):e34094
CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs).
Huang X, Jie S, Li W, Liu C
Heliyon 2024 Jul 15;10(13):e33867
Heliyon 2024 Jul 15;10(13):e33867
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Wu J, Song Y, Wang J, Wang T, Yang L, Shi Y, Song B, Yu Z
Heliyon 2024 Jul 15;10(13):e33802
Heliyon 2024 Jul 15;10(13):e33802
Apple polysaccharide improves age-matched cognitive impairment and intestinal aging through microbiota-gut-brain axis.
Zhang W, Zhong Y, Wang Z, Tang F, Zheng C
Scientific reports 2024 Jul 13;14(1):16215
Scientific reports 2024 Jul 13;14(1):16215
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration.
Du T, Li G, Zong Q, Luo H, Pan Y, Ma K
Immunity & ageing : I & A 2024 Jul 12;21(1):47
Immunity & ageing : I & A 2024 Jul 12;21(1):47
Ultrasound-responsive Bi(2)MoO(6)-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer.
Cheng S, Zhou T, Luo Y, Zhang J, Dong K, Zhang Q, Shu W, Zhang T, Zhang Q, Shi R, Yao Y, Wang H
Journal of nanobiotechnology 2024 Jul 11;22(1):408
Journal of nanobiotechnology 2024 Jul 11;22(1):408
Targeting of G protein-coupled receptor 39 alleviates angiotensin II-induced renal damage by reducing ribonucleotide reductase M2.
Hua D, Huang W, Xu W, Zhang Y, Xie Q, Li P, Sheng Y
Experimental cell research 2024 Jul 1;440(1):114102
Experimental cell research 2024 Jul 1;440(1):114102
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway.
Xie C, Zhou X, Chen W, Ren D, Li X, Jiang R, Zhong C, Zhu J
Chemico-biological interactions 2024 Jul 1;397:111083
Chemico-biological interactions 2024 Jul 1;397:111083
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Li M, Tang S, Velkov T, Shen J, Dai C
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Caveolin-1 scaffolding domain-derived peptide enhances erectile function by regulating oxidative stress, mitochondrial dysfunction, and apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury.
Xi Y, Feng Z, Xia T, Hong Y, Wu J, Chen J, Ge Y, Xiao H
Life sciences 2024 Jul 1;348:122694
Life sciences 2024 Jul 1;348:122694
Melatonin Exerts an Anti-Panoptoic Role in Spinal Cord Ischemia-Reperfusion Injured Rats.
Xie L, Wu H, Shi W, Zhang J, Huang X, Yu T
Advanced biology 2024 Jan;8(1):e2300424
Advanced biology 2024 Jan;8(1):e2300424
Oridonin suppresses the growth of glioblastoma cells via inhibiting Hippo/YAP axis.
Wang C, Zhang Y, Jiang Q, Chen S, Zhang L, Qiu H
Archives of biochemistry and biophysics 2024 Jan;751:109845
Archives of biochemistry and biophysics 2024 Jan;751:109845
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.
Li F, Liu J, Miao J, Hong F, Liu R, Lv Y, Yang Y, He A, Wang J
DNA and cell biology 2024 Jan;43(1):39-55
DNA and cell biology 2024 Jan;43(1):39-55
miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ(1-40) -induced SH-SY5Y cells by increasing NEP expression.
Chen H, Huang Z, Lei A, Yu X, Shen M, Wu D
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23624
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23624
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.
Liu Z, Feng C, Li C, He T, Wu G, Fu C, Li H, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332
Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer.
Wang X, Lu H, Luo F, Wang D, Wang A, Wang X, Feng W, Wang X, Su J, Liu M, Xia G
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:112-131
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:112-131
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling.
Zhang Q, Tian L, Hu Y, Jiang W, Wang X, Chen L, Cheng S, Ying J, Jiang B, Zhang L
Toxicology mechanisms and methods 2024 Jan;34(1):20-31
Toxicology mechanisms and methods 2024 Jan;34(1):20-31
Chemo-immunotherapy by dual-enzyme responsive peptide self-assembling abolish melanoma.
Wang Y, Xie L, Li X, Wang L, Yang Z
Bioactive materials 2024 Jan;31:549-562
Bioactive materials 2024 Jan;31:549-562
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Wang W, Yu R, Wu C, Li Q, Chen J, Xiao Y, Chen H, Song J, Ji M, Zuo Z
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity.
Ren J, Wu H, Lu Z, Qin Q, Jiao X, Meng G, Liu W, Li G
International journal of biological macromolecules 2024 Jan;256(Pt 1):128383
International journal of biological macromolecules 2024 Jan;256(Pt 1):128383
CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression.
Zhou Z, Ye Q, Ren H, Zhang Y, Han B, Yao H, Bai Y
International journal of biological macromolecules 2024 Jan;254(Pt 3):127922
International journal of biological macromolecules 2024 Jan;254(Pt 3):127922
The P38MAPK/ATF2 signaling pathway is involved in PND in mice.
Zhu M, Long S, Tao Y, Zhang Z, Zhou Z, Wang X, Chen W
Experimental brain research 2024 Jan;242(1):109-121
Experimental brain research 2024 Jan;242(1):109-121
Carfilzomib suppressed LDHA-mediated metabolic reprogramming by targeting ATF3 in esophageal squamous cell carcinoma.
Chen L, Shi H, Zhang W, Zhu Y, Chen H, Wu Z, Qi H, Liu J, Zhong M, Shi X, Wang T, Li Q
Biochemical pharmacology 2024 Jan;219:115939
Biochemical pharmacology 2024 Jan;219:115939
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Zhou L, Cai E, Liu H, Cheng H, Ye X, Zhu H, Chang X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54
Molecular immunology 2024 Jan;165:42-54
CircMAP3K5 promotes cardiomyocyte apoptosis in diabetic cardiomyopathy by regulating miR-22-3p/DAPK2 Axis.
Shen M, Wu Y, Li L, Zhang L, Liu G, Wang R
Journal of diabetes 2024 Jan;16(1):e13471
Journal of diabetes 2024 Jan;16(1):e13471
hUC-MSC-EV-miR-24 enhances the protective effect of dexmedetomidine preconditioning against myocardial ischemia-reperfusion injury through the KEAP1/Nrf2/HO-1 signaling.
Hou Z, Yang F, Chen K, Wang Y, Qin J, Liang F
Drug delivery and translational research 2024 Jan;14(1):143-157
Drug delivery and translational research 2024 Jan;14(1):143-157
The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition.
Lu CS, Wu CY, Wang YH, Hu QQ, Sun RY, Pan MJ, Lu XY, Zhu T, Luo S, Yang HJ, Wang D, Wang HW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155217
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155217
Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC.
Xu F, Zang T, Chen H, Zhou C, Wang R, Yu Y, Shen L, Qian J, Ge J
Cellular signalling 2024 Jan;113:110937
Cellular signalling 2024 Jan;113:110937
Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway.
Fan J, Zhang Z, Chen H, Chen D, Yuan W, Li J, Zeng Y, Zhou S, Zhang S, Zhang G, Xiong J, Zhou L, Xu J, Liu W, Xu Y
Genes & diseases 2024 Jan;11(1):430-448
Genes & diseases 2024 Jan;11(1):430-448
Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR.
Xi S, Ding W, Weng D, Zeng Y, Gao K, Wu Q, Huang G, Li Y, Yue H
Chemical biology & drug design 2024 Jan;103(1):e14417
Chemical biology & drug design 2024 Jan;103(1):e14417
let-7g sensitized liver cancer cells to 5-fluorouracil by downregulating ABCC10 expression.
Chen Y, Zhang B, Zhong C, Zhou Y, Xue L, Luo C, Yi L, Gong Q, Long Y
Chemical biology & drug design 2024 Jan;103(1):e14396
Chemical biology & drug design 2024 Jan;103(1):e14396
Ganoderic acid A slows osteoarthritis progression by attenuating endoplasmic reticulum stress and blocking NF-Κb pathway.
Liu Y, Zhou C, Tan J, Wu T, Pan C, Liu J, Cheng X
Chemical biology & drug design 2024 Jan;103(1):e14382
Chemical biology & drug design 2024 Jan;103(1):e14382
Hsa_circ_0013561 promotes progression of nasopharyngeal carcinoma by activating JAK2/STAT3 signaling pathway.
Kaisai T, Mantang Z, Tailei Y, Liying Z, Xiaoping C, Mingming J, Yi Z
Brazilian journal of otorhinolaryngology 2024 Jan-Feb;90(1):101362
Brazilian journal of otorhinolaryngology 2024 Jan-Feb;90(1):101362
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cai Y, Yang H, Wan Z, Chen PY, Wang ZB, Guo JJ, Wang D, Wang F, Zhang Y
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Peng L, Yang R, Wang Z, Jian H, Tan X, Li J, He Z, Huang R, Zeng P, Gao W
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling.
Hu Y, Liu Y, Wang H, Wang X
Human & experimental toxicology 2024 Jan-Dec;43:9603271241306396
Human & experimental toxicology 2024 Jan-Dec;43:9603271241306396
Arsenic-induced downregulation of BRWD3 suppresses proliferation and induces apoptosis in lung adenocarcinoma cells through the p53 and p65 pathways.
Zhu Y, Xiao M, Zhao R, Yang X, Wu K, Liu X, Chen X, Guo L, Liu J, Chen X, Liu N, He Y, Zhang Y
Human & experimental toxicology 2024 Jan-Dec;43:9603271241279166
Human & experimental toxicology 2024 Jan-Dec;43:9603271241279166
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Tian X, Wei J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells.
Jedram O, Maphanao P, Karnchanapandh K, Mahalapbutr P, Thanan R, Sakonsinsiri C
ACS omega 2024 Jan 9;9(1):1278-1286
ACS omega 2024 Jan 9;9(1):1278-1286
Celastrol Alleviates Mitochondrial Oxidative Stress and Brain Injury After Intracerebral Hemorrhage by Promoting OPA1-Dependent Mitochondrial Fusion.
Diao C, Yang Z, Hu Q, Yao P, Qu X, Li C, Zhang S, Zhou J
Neuroscience 2024 Jan 9;536:79-91
Neuroscience 2024 Jan 9;536:79-91
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma.
Wang J, Ma C, Tang Z, Sun Z, Qaed E, Chi X, Wang J, Jamalat Y, Geng Z, Tang Z, Yao Q
Cancer cell international 2024 Jan 7;24(1):17
Cancer cell international 2024 Jan 7;24(1):17
Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.
Li A, Chen AJ, Xu J, Wen ZY, Bai GL, Wang ZY, Jiang YX, Wang P
Molecular biology reports 2024 Jan 6;51(1):80
Molecular biology reports 2024 Jan 6;51(1):80
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway.
Chen K, Yu G
European journal of pharmacology 2024 Jan 5;962:176251
European journal of pharmacology 2024 Jan 5;962:176251
Unlocking the role of EIF5A: A potential diagnostic marker regulating the cell cycle and showing negative correlation with immune infiltration in lung adenocarcinoma.
Yang Z, Yuan H, He H, Qi S, Zhu X, Hu X, Jin M, Zhang XX, Yuan ZG
International immunopharmacology 2024 Jan 5;126:111227
International immunopharmacology 2024 Jan 5;126:111227
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183
International immunopharmacology 2024 Jan 5;126:111183
Protective effect of apelin-13 on ventilator-induced acute lung injury.
Lian S, Zhang X, Shen Y, He S, Chen Z, Zhou L, Jiang W
Molecular biology reports 2024 Jan 4;51(1):74
Molecular biology reports 2024 Jan 4;51(1):74
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer.
Zhu Q, Cao Y, Yuan J, Hu Y
Cancer immunology, immunotherapy : CII 2024 Jan 31;73(2):39
Cancer immunology, immunotherapy : CII 2024 Jan 31;73(2):39
Targeting ENPP1 depletion may be a promising therapeutic strategy for treating oral squamous cell carcinoma via cytotoxic autophagy-related apoptosis.
Ma C, Zhao J, Zhou L, Jia C, Shi Y, Li X, Jihu K, Zhang T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23420
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23420
Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline.
Zhang X, Zheng H, Ni Z, Shen Y, Wang D, Li W, Zhao L, Li C, Gao H
Cerebral cortex (New York, N.Y. : 1991) 2024 Jan 31;34(2)
Cerebral cortex (New York, N.Y. : 1991) 2024 Jan 31;34(2)
Sinensetin suppresses breast cancer cell progression via Wnt/β-catenin pathway inhibition.
Zhu S, Meng L, Wei P, Gu G, Duan K
Translational cancer research 2024 Jan 31;13(1):348-362
Translational cancer research 2024 Jan 31;13(1):348-362
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Jin H, Liu C, Liu X, Wang H, Zhang Y, Liu Y, Li J, Yu Z, Liu HX
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
The lncRNA GAS5 upregulates ANXA2 to mediate the macrophage inflammatory response during atherosclerosis development.
Xue Y, Hu Y, Yu S, Zhu W, Liu L, Luo M, Luo S, Shen J, Huang L, Liu J, Lv D, Zhang W, Wang J, Li X
Heliyon 2024 Jan 30;10(2):e24103
Heliyon 2024 Jan 30;10(2):e24103
Study of the effect of keap1 on oxidative stress in human umbilical cord mesenchymal stem cells.
Deng H, Chen Y, Liu H, Wang L, Xu H, Tan B, Yi Q, Wang R, He B, Tian J, Zhu J
Molecular biology reports 2024 Jan 3;51(1):67
Molecular biology reports 2024 Jan 3;51(1):67
The effect and mechanism of selenium supplementation on the proliferation capacity of bovine endometrial epithelial cells exposed to lipopolysaccharide in vitro under high cortisol background.
Li H, Dong J, Cui L, Liu K, Guo L, Li J, Wang H
Journal of animal science 2024 Jan 3;102
Journal of animal science 2024 Jan 3;102
Circ-phkb promotes cell apoptosis and inflammation in LPS-induced alveolar macrophages via the TLR4/MyD88/NF-kB/CCL2 axis.
Wei X, Yi X, Liu J, Sui X, Li L, Li M, Lv H, Yi H
Respiratory research 2024 Jan 29;25(1):62
Respiratory research 2024 Jan 29;25(1):62
Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
Jiang W, Hou Q, Xu H, Yang K, Wang X, Zhang K, Zeng Y, Li W, Wang B, Luo G, Zhao X, Shen H, Xu Y, Wu X
Journal of medicinal chemistry 2024 Jan 25;67(2):1513-1532
Journal of medicinal chemistry 2024 Jan 25;67(2):1513-1532
Astaxanthin Inhibits H(2)O(2)-Induced Excessive Mitophagy and Apoptosis in SH-SY5Y Cells by Regulation of Akt/mTOR Activation.
Yan T, Ding F, Zhang Y, Wang Y, Wang Y, Zhang Y, Zhu F, Zhang G, Zheng X, Jia G, Zhou F, Zhao Y, Zhao Y
Marine drugs 2024 Jan 24;22(2)
Marine drugs 2024 Jan 24;22(2)
circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression.
Li S, Qiu C, Sun D, Yang S, Wang L
European journal of medical research 2024 Jan 20;29(1):67
European journal of medical research 2024 Jan 20;29(1):67
Cath-KP, a novel peptide derived from frog skin, prevents oxidative stress damage in a Parkinson's disease model.
Lu H, Chai J, Xu Z, Wu J, He S, Liao H, Huang P, Huang X, Chen X, Jiang H, Qu S, Xu X
Zoological research 2024 Jan 18;45(1):108-124
Zoological research 2024 Jan 18;45(1):108-124
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response.
Lin N, Sun L, Chai J, Qi H, Zhao Y, Ma J, Xia M, Hu X
Cancer cell international 2024 Jan 18;24(1):38
Cancer cell international 2024 Jan 18;24(1):38
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway.
Qaed E, Alyafeai E, Al-Maamari A, Zaky MY, Almoiliqy M, Al-Hamyari B, Qaid A, Yafei S, Aldahmash W, Mahyoub MA, Wang F, Kang L, Tang Z, Zhang J
Journal of molecular neuroscience : MN 2024 Jan 17;74(1):11
Journal of molecular neuroscience : MN 2024 Jan 17;74(1):11
DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis.
Jin H, Yang Y, Zhu X, Zhou Y, Xu Y, Li J, Qi C, Shao X, Wu J, Wu S, Cai H, Gu L, Mou S, Ni Z, Li S, Lin Q
Cell death & disease 2024 Jan 17;15(1):63
Cell death & disease 2024 Jan 17;15(1):63
Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction.
Chen Q, Chen Q, Song Y, Xiang Y, Li Q, Sang Y, Zhang L, Bai L, Zhu Y
Molecular and cellular endocrinology 2024 Jan 15;580:112084
Molecular and cellular endocrinology 2024 Jan 15;580:112084
Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway.
Peng ML, Zhang LJ, Luo Y, Xu SY, Long XM, Ao JL, Liao SG, Zhu QF, He X, Xu GB
Molecules (Basel, Switzerland) 2024 Jan 15;29(2)
Molecules (Basel, Switzerland) 2024 Jan 15;29(2)
Autophagic and apoptotic proteins in goat corpus luteum and the effect of Adiponectin/AdipoRon on luteal cell autophagy and apoptosis.
Li H, Pei X, Yu H, Wang W, Mao D
Theriogenology 2024 Jan 15;214:245-256
Theriogenology 2024 Jan 15;214:245-256
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway.
Di X, Pan Y, Yan J, Liu J, Wen D, Jiang H, Zhang S
Heliyon 2024 Jan 15;10(1):e23165
Heliyon 2024 Jan 15;10(1):e23165
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth.
Zuo Y, Bai J, Bai H, Tian S, Sun H, Shi Z, Yu P, Gao G, Li Y, Chang YZ
Cell death & disease 2024 Jan 13;15(1):49
Cell death & disease 2024 Jan 13;15(1):49
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Gentiopicroside inhibits the progression of gastric cancer through modulating EGFR/PI3K/AKT signaling pathway.
Chen Q, Zhang T, Li B, Zhu Z, Ma X, Zhang Y, Li L, Zhu J, Zhang G
European journal of medical research 2024 Jan 11;29(1):47
European journal of medical research 2024 Jan 11;29(1):47
E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis.
Huang Y, Chen T, Jiang M, Xiong C, Mei C, Nie J, Zhang Q, Zhu Q, Huang X, Zhang X, Li Y
Cell death & disease 2024 Jan 11;15(1):29
Cell death & disease 2024 Jan 11;15(1):29
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Hu W, Xie N, Pan M, Zhang Q, Zhang H, Wang F, Qu F
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Mechanism of Xiaojianzhong decoction in alleviating aspirin-induced gastric mucosal injury revealed by transcriptomics and metabolomics.
Chen T, Chen J, Bao SC, Zhang JX, Wei HL, Zhou XY, Hu X, Liang Y, Li JT, Yan SG
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116910
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116910
Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation.
Yang T, Liu X, Zhou Y, Du L, Fu Y, Luo Y, Zhang W, Feng Z, Ge J, Mei Z
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116898
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116898
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Li Y, Zhong G, Li L, Li T, Li H, Li Y, Zhang H, Pan J, Hu L, Liao J, Yu W, Tang Z
The Science of the total environment 2024 Jan 1;906:167825
The Science of the total environment 2024 Jan 1;906:167825
Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression.
Zhou Y, Xiao Y, Liu H, Chen Q, Zhu L, Zeng L, Liu X, Pan Y, Zhang J, Fu J, Shao C
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C60-C73
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C60-C73
Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy.
Zhao G, Zhang T, Li J, Li L, Chen P, Zhang C, Li K, Cui C
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C214-C228
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C214-C228
Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO/cGMP pathway.
Zhao CB, Chen WB, Wang WZ, Gong FX, Fan CQ, Li Y, Lan T, Wang WJ, Yuan MZ
Asian journal of andrology 2024 Jan 1;26(1):57-66
Asian journal of andrology 2024 Jan 1;26(1):57-66
Hypomethylating agent decitabine sensitizes diffuse large B-cell lymphoma to venetoclax.
Zhu F, Crombie JL, Ni W, Hoang NM, Garg S, Hackett L, Chong SJF, Collins MC, Rui L, Griffin J, Davids MS
Haematologica 2024 Jan 1;109(1):186-199
Haematologica 2024 Jan 1;109(1):186-199
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB
Archives of biochemistry and biophysics 2024 Feb;752:109855
Archives of biochemistry and biophysics 2024 Feb;752:109855
Alisol A Exerts Neuroprotective Effects Against HFD-Induced Pathological Brain Aging via the SIRT3-NF-κB/MAPK Pathway.
Lu T, Ding L, Zheng X, Li Y, Wei W, Liu W, Tao J, Xue X
Molecular neurobiology 2024 Feb;61(2):753-771
Molecular neurobiology 2024 Feb;61(2):753-771
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.
Li L, Xin L, Yang X, Zou Z
Journal of molecular histology 2024 Feb;55(1):97-108
Journal of molecular histology 2024 Feb;55(1):97-108
Aucubin provides protection against cerebral ischaemia-reperfusion injury by suppressing neuronal apoptosis, oxidative stress, and inflammation through the modulation of the AKT-GSK-3β-Nrf2 signal cascade.
Yang F, Lian Q, Zhang X, Sun F, Jia S, Zhao W
Toxicology and applied pharmacology 2024 Feb;483:116829
Toxicology and applied pharmacology 2024 Feb;483:116829
Synergistic effect of adavosertib and fimepinostat on acute myeloid leukemia cells by enhancing the induction of DNA damage.
Wang Y, Lin X, Wang Y, Wang G
Investigational new drugs 2024 Feb;42(1):70-79
Investigational new drugs 2024 Feb;42(1):70-79
Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2.
Bai W, Liu D, Cheng Q, Yang X, Zhu L, Qin L, Fang J
Translational oncology 2024 Feb;40:101850
Translational oncology 2024 Feb;40:101850
Iron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases.
Li J, Ding Y, Zhang J, Zhang Y, Cui Y, Zhang Y, Chang S, Chang YZ, Gao G
CNS neuroscience & therapeutics 2024 Feb;30(2):e14394
CNS neuroscience & therapeutics 2024 Feb;30(2):e14394
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Xu M, Li F, Xu X, Hu N, Miao J, Zhao Y, Ji S, Wang Y, Wang L
Ecotoxicology and environmental safety 2024 Feb;271:115989
Ecotoxicology and environmental safety 2024 Feb;271:115989
Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands.
Tian W, Zhong W, Yang Z, Chen L, Lin S, Li Y, Wang Y, Yang P, Long X
Journal of inorganic biochemistry 2024 Feb;251:112434
Journal of inorganic biochemistry 2024 Feb;251:112434
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation.
Hu Z, Xu D, Meng H, Liu W, Zheng Q, Wang J
Biochemical pharmacology 2024 Feb;220:115992
Biochemical pharmacology 2024 Feb;220:115992
Activation of the melanocortin-1 receptor attenuates neuronal apoptosis after traumatic brain injury by upregulating Merlin expression.
Lu J, Wang J, Ni H, Li B, Yang J, Zhu J, Qian J, Gao R, Xu R
Brain research bulletin 2024 Feb;207:110870
Brain research bulletin 2024 Feb;207:110870
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Zhang W, Sun J, Liu F, Li S, Wang X, Su L, Liu G
Biological trace element research 2024 Feb;202(2):624-642
Biological trace element research 2024 Feb;202(2):624-642
GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition.
Li M, Wang X, Chen X, Hong J, Du Y, Song D
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166925
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166925
The augmentation of cytotoxic immune cell functionality through physical exertion bolsters the potency of chemotherapy in models of mammary carcinoma.
Qin B, He Z, Xie L, Feng S, Ye J, Gui J, Sun X, Sang M
Cancer medicine 2024 Feb;13(3):e6951
Cancer medicine 2024 Feb;13(3):e6951
Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.
Yang R, Hu N, Liu TY, Qu Y, Liu J, Wang JH, Yang BF, Li CL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155326
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155326
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Meng M, Wang J, Wang C, Zhao J, Wang H, Zhang Y, Sun H, Liu M
Calcified tissue international 2024 Feb;114(2):182-199
Calcified tissue international 2024 Feb;114(2):182-199
Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer.
Zhong C, Zhu R, Jiang T, Tian S, Zhao X, Wan X, Jiang S, Chen Z, Gong R, He L, Yang JM, Ye N, Cheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2305035
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(5):e2305035
Sinigrin improves cerebral ischaemia-reperfusion injury by inhibiting the TLR4 pathway-mediated oxidative stress.
Guo S, Lei Q, Yang Q, Chen R
Chemical biology & drug design 2024 Feb;103(2):e14480
Chemical biology & drug design 2024 Feb;103(2):e14480
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.
Zhou J, Yao L, Su Y, Tian L
Chemical biology & drug design 2024 Feb;103(2):e14473
Chemical biology & drug design 2024 Feb;103(2):e14473
USF2 promotes autophagy and proliferation in chronic lymphocytic leukemia by inhibiting STUB1-induced NFAT5 ubiquitination.
Chen B, Zhao Y, Xu S, Jiang F, Nie Y, Tang A, Zhou Q
Annals of hematology 2024 Feb;103(2):533-544
Annals of hematology 2024 Feb;103(2):533-544
Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
Li J, Liu Y, He J, Wu Z, Wang F, Huang J, Zheng L, Luo T
Journal of ovarian research 2024 Feb 6;17(1):35
Journal of ovarian research 2024 Feb 6;17(1):35
Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway.
Mi T, Zhang Z, Zhanghuang C, Jin L, Tan X, Liu J, Wu X, Li M, Wang J, Wang Z, Guo P, He D
European journal of pharmacology 2024 Feb 5;964:176291
European journal of pharmacology 2024 Feb 5;964:176291
Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway.
Wu M, Liu X, Yu Q, Shi J, Guo W, Zhang S
European journal of pharmacology 2024 Feb 5;964:176224
European journal of pharmacology 2024 Feb 5;964:176224
Inhibiting Liver Autophagy and Promoting Hepatocyte Apoptosis by Schistosoma japonicum Infection.
Yu Z, Jiang T, Xu F, Zhang J, Hu Y, Cao J
Tropical medicine and infectious disease 2024 Feb 4;9(2)
Tropical medicine and infectious disease 2024 Feb 4;9(2)
Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice.
Yang YH, Chen C, Zheng Y, Wu ZJ, Zhou MQ, Liu XY, Miyashita K, Duan DL, Du L
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4142-4154
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4142-4154
Rapid Discovery of Aβ(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Li QM, Han HH, Zang DD, Zha XQ, Zhou A, Zhang FY, Luo JP
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4127-4141
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4127-4141
Integrin α(4) Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction.
Yuan Z, Tan J, Wang J
International journal of stem cells 2024 Feb 28;17(1):70-79
International journal of stem cells 2024 Feb 28;17(1):70-79
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6.
Wang X, Li X, Zhou J, Lei Z, Yang X
Chemico-biological interactions 2024 Feb 25;390:110890
Chemico-biological interactions 2024 Feb 25;390:110890
Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Tan W, Li Y, Ma L, Fu X, Long Q, Yan F, Li W, Liu X, Ding H, Wang Y, Zhang W
Scientific reports 2024 Feb 23;14(1):4465
Scientific reports 2024 Feb 23;14(1):4465
Atractylenolide II Suppresses Glycolysis and Induces Apoptosis by Blocking the PADI3-ERK Signaling Pathway in Endometrial Cancer Cells.
Tian S, Ren L, Liu C, Wang Z
Molecules (Basel, Switzerland) 2024 Feb 21;29(5)
Molecules (Basel, Switzerland) 2024 Feb 21;29(5)
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.
Wei J, Chen Y, Feng T, Wei Y, Yang C, Zhang C, Li W, Liu G
Functional & integrative genomics 2024 Feb 20;24(2):37
Functional & integrative genomics 2024 Feb 20;24(2):37
Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice.
Fu Y, Zhang YL, Liu RQ, Xu MM, Xie JL, Zhang XL, Xie GM, Han YT, Zhang XM, Zhang WT, Zhang J, Zhang J
Journal of nanobiotechnology 2024 Feb 17;22(1):66
Journal of nanobiotechnology 2024 Feb 17;22(1):66
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis.
He Y, Zhu G, Li X, Zhou M, Guan MX
iScience 2024 Feb 16;27(2):108883
iScience 2024 Feb 16;27(2):108883
Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer.
Ning JY, Ma B, Huang JY, Han L, Shao YH, Wang FY
Journal of pharmaceutical and biomedical analysis 2024 Feb 15;239:115883
Journal of pharmaceutical and biomedical analysis 2024 Feb 15;239:115883
Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis.
Zhang X, Hu Q, Jiang B, Xie F, Zhang Z, Hafezi-Moghadam A, Sun D
International immunopharmacology 2024 Feb 15;128:111480
International immunopharmacology 2024 Feb 15;128:111480
Puerarin Ameliorated PCOS through Preventing Mitochondrial Dysfunction Dependent on the Maintenance of Intracellular Calcium Homeostasis.
Wang YS, Li BY, Xing YF, Huang JC, Chen ZS, Yue L, Zou YG, Guo B
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Journal of agricultural and food chemistry 2024 Feb 14;72(6):2963-2976
Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types.
He Y, Lu F, Jiang C, Gong F, Wu Z, Ostrikov K
Scientific reports 2024 Feb 13;14(1):3599
Scientific reports 2024 Feb 13;14(1):3599
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
Zhang F, Hao Y, Yang N, Liu M, Luo Y, Zhang Y, Zhou J, Liu H, Li J
BMC cancer 2024 Feb 12;24(1):198
BMC cancer 2024 Feb 12;24(1):198
Baicalein improves Na(2)SeO(3) induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat.
Hu N, Jin FY, Gao MM, Liu LJ, Wang JH, Yang BF, Li CL
Journal of ethnopharmacology 2024 Feb 10;320:117433
Journal of ethnopharmacology 2024 Feb 10;320:117433
Jingfang Granule mitigates Coxsackievirus B3-induced myocardial damage by modulating mucolipin 1 expression.
Sun B, Lin L, Yao T, Yao J, Zhang G, Li Y, Li C
Journal of ethnopharmacology 2024 Feb 10;320:117396
Journal of ethnopharmacology 2024 Feb 10;320:117396
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.
Zhao L, Miao H, Quan M, Wang S, Zhang Y, Zhou H, Zhang X, Lin Z, Piao J
Chemico-biological interactions 2024 Feb 1;389:110866
Chemico-biological interactions 2024 Feb 1;389:110866
miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4.
Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
Reproductive biology and endocrinology : RB&E 2024 Feb 1;22(1):17
IGF-PLGA microspheres promote angiogenesis and accelerate skin flap repair and healing by inhibiting oxidative stress and regulating the Ang 1/Tie 2 signaling pathway.
Hu F, Huang K, Zhang H, Hu W, Tong S, Xu H
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Feb 1;193:106687
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Feb 1;193:106687
Curcumin triggers the Wnt/β-catenin pathway and shields neurons from injury caused by intermittent hypoxia.
He Y, Zhao Y, Lv RJ, Dong N, Wang X, Yu Q, Yue HM
Tissue & cell 2024 Dec;91:102587
Tissue & cell 2024 Dec;91:102587
MiR-200b-3p elevates 5-FU sensitivity in cholangiocarcinoma cells via autophagy inhibition by targeting KLF4.
Peng F, He R, Liu Y, Xie Y, Xiong G, Li X, Wang M, Zhao C, Zhang H, Xu S, Qin R
Non-coding RNA research 2024 Dec;9(4):1098-1110
Non-coding RNA research 2024 Dec;9(4):1098-1110
Quercetin attenuates cadmium-induced hepatotoxicity by suppressing oxidative stress and apoptosis in rat.
Shi Y, Wang K, Ling H, Mao J, Xu B, Liu Z, Wang J
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 Dec;86:127554
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 Dec;86:127554
Effects of sulforaphane on prostate cancer stem cells-like properties: In vitro and molecular docking studies.
Xuan Y, Xu J, Que H, Zhu J
Archives of biochemistry and biophysics 2024 Dec;762:110216
Archives of biochemistry and biophysics 2024 Dec;762:110216
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
Ge X, Gu Y, Wang W, Guo W, Wang P, Du P
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress.
Deng X, Zhang Y, He X, Li L, Yue Z, Liang Y, Huang Y
Journal of bioenergetics and biomembranes 2024 Dec;56(6):619-630
Journal of bioenergetics and biomembranes 2024 Dec;56(6):619-630
Erxian decoction ameliorates myocardial tissue damage through activating PI3K/AKT signaling pathway in ovariectomized rats.
Yang Y, Liu H, Hu J, Ma Y, Li P, Zhang Z, Chen Y
Annals of medicine 2024 Dec;56(1):2411013
Annals of medicine 2024 Dec;56(1):2411013
In silico and in vivo verification of the mechanism of formononetin in treating hepatocellular carcinoma.
Ma G, Pang X, Ran Y, Chen W, Zhou Y, Li X, Liu B, Li F, Hu S
Annals of medicine 2024 Dec;56(1):2404550
Annals of medicine 2024 Dec;56(1):2404550
Exploring the roles and therapeutic implications of melatonin-mediated KLF6 in the development of intracranial aneurysm.
Liu Y, Su Y, Chen L, Li A, Ma Z
Annals of medicine 2024 Dec;56(1):2397568
Annals of medicine 2024 Dec;56(1):2397568
Focused Ultrasound Combined With Microbubbles Attenuate Symptoms in Heroin-Addicted Mice.
Feng Y, Sun J, Wang T, Zheng Y, Zhao Y, Li Y, Lai S, Xu Y, Zhu M
Ultrasound in medicine & biology 2024 Dec;50(12):1764-1776
Ultrasound in medicine & biology 2024 Dec;50(12):1764-1776
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Gao S, Cheng Q, Hu Y, Fan X, Liang C, Niu C, Kang Q, Wei T
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction.
Zhang Y, Lv L, Zhou Z, Zhang H, Li Q, Yang S, Wen Y, Wang Q, Feng J, Lu W, Jia W, Wen JG
Renal failure 2024 Dec;46(2):2415519
Renal failure 2024 Dec;46(2):2415519
miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis.
Li H, Duan J, Zhang T, Fu Y, Xu Y, Miao H, Ge X
Renal failure 2024 Dec;46(1):2322688
Renal failure 2024 Dec;46(1):2322688
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).
Chen L, Cheng S, Ying J, Zhang Q, Wang C, Wu H, Wang Y, Zhang H, Wang J, Ye J, Zhang L
Toxicology letters 2024 Dec;402:44-55
Toxicology letters 2024 Dec;402:44-55
Exposure to Polypropylene Microplastics Causes Cardiomyocyte Apoptosis Through Oxidative Stress and Activation of the MAPK-Nrf2 Signaling Pathway.
Lu T, Yuan X, Sui C, Yang C, Li D, Liu H, Zhang G, Li G, Li S, Zhang J, Zhou L, Xu M
Environmental toxicology 2024 Dec;39(12):5371-5381
Environmental toxicology 2024 Dec;39(12):5371-5381
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
Chen J, Zhao L, Xu MF, Huang D, Sun XL, Zhang YX, Li HM, Wu CZ
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2292006
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2292006
LncRNA 93358 Aggravates the Apoptosis of Myocardial Cells After Ischemia-Reperfusion by Mediating the PI3K/AKT/mTOR Pathway.
Cai J, Zhang Z, Chen L, Wang X, Zhong Y, Xie D, Liao W
Journal of biochemical and molecular toxicology 2024 Dec;38(12):e70085
Journal of biochemical and molecular toxicology 2024 Dec;38(12):e70085
A cisplatin and disulphiram co-loaded inclusion complex overcomes drug resistance by inhibiting cancer cell stemness in non-small cell lung cancer.
Ye W, Lv H, Zhang Q, Zhao J, Zhao X, Zhao G, Yan C, Sun F, Zhao Z, Jia X
Journal of drug targeting 2024 Dec;32(2):159-171
Journal of drug targeting 2024 Dec;32(2):159-171
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
Cai S, Ding R, Zhang H, Chen Q, Yu F, Xia Y, Chen Q, Miao X, Zhou B, Chen J, Liao L, Cheng X, Fu X
Materials today. Bio 2024 Dec;29:101323
Materials today. Bio 2024 Dec;29:101323
Angelica sinensis polysaccharides mitigate cadmium-induced apoptosis in layer chicken chondrocytes by inhibiting the JNK signaling pathway.
Tong X, Wang G, Zhao X, Zhou J, Wang P, Xia H, Bian J, Liu X, Yuan Y, Zou H, Liu Z, Gu J
International journal of biological macromolecules 2024 Dec;282(Pt 5):137106
International journal of biological macromolecules 2024 Dec;282(Pt 5):137106
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Xing Y, Ge J, Wang Y, Zhou X, Yuan Z, Lv M, Zhao M, Liu L, Gong D, Geng T, Xie K
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
Self-assembled metal-polyphenolic based multifunctional nanomedicine to improve therapy treatment of pancreatic cancer by inhibition of glutamine metabolism.
Dai Y, Li J, Wang T, Zhang X, Du P, Dong Y, Jiao Z
Colloids and surfaces. B, Biointerfaces 2024 Dec;244:114162
Colloids and surfaces. B, Biointerfaces 2024 Dec;244:114162
Tanshinone IIA Exerts Cardioprotective Effects Through Improving Gut-Brain Axis Post-Myocardial Infarction.
Zhu T, Chen J, Zhang M, Tang Z, Tong J, Hao X, Li H, Xu J, Yang J
Cardiovascular toxicology 2024 Dec;24(12):1317-1334
Cardiovascular toxicology 2024 Dec;24(12):1317-1334
Critical role of apoptosis in MeCP2-mediated epithelial-mesenchymal transition of ARPE-19 cells.
Zhang Y, Wu F, Guo S, Yin R, Yuan M, Li X, Zhao X, Li X
Journal of cellular physiology 2024 Dec;239(12):e31429
Journal of cellular physiology 2024 Dec;239(12):e31429
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Liu W, Dou C, Zhang C, Chen P, Zhang S, Wang R, Han Q, Zhao H, Li D
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.
Liu F, Lv LF, Bi FF, Pan QM, Jing ZH, Cui C, Cao M, Yu T, Li J, He YJ, Xiao HW, Tian H, Wu Y, Shan HL, Zhou YH
Biochemical pharmacology 2024 Dec;230(Pt 2):116597
Biochemical pharmacology 2024 Dec;230(Pt 2):116597
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Zhang G, Wen F, Li Y, Sun P, Li Y, Hu Z, Wang H, Ma Y, Liang G, Chen L, Yang K, Hu J
Theriogenology 2024 Dec;230:330-340
Theriogenology 2024 Dec;230:330-340
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
Wang YQ, Dong YW, Qu HX, Qi JJ, Yan CX, Wei HK, Sun H, Sun BX, Liang S
Theriogenology 2024 Dec;230:203-211
Theriogenology 2024 Dec;230:203-211
Mechanism of ginsenoside Rb(3) against OGD/R damage based on metabonomic and PCR array analyses.
Li F, Tao J, Zhou M, Yu X, Xiao T, Wang C, Duan X
Biomedical reports 2024 Dec;21(6):187
Biomedical reports 2024 Dec;21(6):187
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Fang H, Xu M, Zhang J, Qin H, Tang H, He Y, Guo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
Ma J, Dong D, Qi H, Li J, Yu H, Hu X, Sun L, Shen L
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167453
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167453
In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent.
Zhu H, Li H, Ji Y, Hou M, Yang Q, Liang L, Li W
Bioorganic chemistry 2024 Dec;153:107949
Bioorganic chemistry 2024 Dec;153:107949
Altingia chinensis petroleum ether extract suppresses NSCLC via induction of apoptosis, attenuation of EMT, and downregulation of PI3K/Akt pathway.
Qin Y, Zhang D, Shangguan C, Xu C, Li S, Li Y, Liu Y, Jiang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156218
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156218
Chidan Tuihuang granule modulates gut microbiota to influence NOD1/RIPK2 pathway in cholestatic liver injury recovery.
Chen Y, Hu Q, Zhang W, Gong Q, Yan J, Wang Z, Zhou Z, Ma X, Li Y, Lu X, Efferth T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156164
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156164
Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection.
Zhang Q, Sun G, Yue F, Liu Z, Li P, Zhu Y, Zhu Y, Niu R, Sun Z, Wang X, Zhang G
Poultry science 2024 Dec;103(12):104389
Poultry science 2024 Dec;103(12):104389
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.
Su Q, Chen K, Ren J, Zhang Y, Han X, Leong SW, Wang J, Wu Q, Tu K, Sarwar A, Zhang Y
Journal of molecular medicine (Berlin, Germany) 2024 Dec;102(12):1471-1484
Journal of molecular medicine (Berlin, Germany) 2024 Dec;102(12):1471-1484
Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.
Yang J, Cai JH, Wu TX, Gao ZQ, Zhou C, Wu Q, Ji MJ
Journal of ethnopharmacology 2024 Dec 5;335:118697
Journal of ethnopharmacology 2024 Dec 5;335:118697
Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.
Mo J, Liao W, Du J, Huang X, Li Y, Su A, Zhong L, Gong M, Wang P, Liu Z, Kuang H, Wang L
Journal of ethnopharmacology 2024 Dec 5;335:118636
Journal of ethnopharmacology 2024 Dec 5;335:118636
Mechanistic study of quercetin in the treatment of hepatocellular carcinoma with diabetes via MEK/ERK pathway.
Lin F, Zhou W, Yuan X, Liu S, He Z
International immunopharmacology 2024 Dec 5;142(Pt B):113194
International immunopharmacology 2024 Dec 5;142(Pt B):113194
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress.
Guo X, Wang P, Wei H, Yan J, Zhang D, Qian Y, Guo B
International immunopharmacology 2024 Dec 5;142(Pt B):113134
International immunopharmacology 2024 Dec 5;142(Pt B):113134
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Identification of a nomogram predicting overall survival based on ADAP2-related apoptosis genes in gliomas.
Zhang C, Wang J, Niu Z, Zhang K, Wang C, Wang S, Hou S, Yu D, Lin N
International immunopharmacology 2024 Dec 5;142(Pt A):113084
International immunopharmacology 2024 Dec 5;142(Pt A):113084
Tenovin-6 exhibits inhibitory effects on the growth of Sonic Hedgehog (SHH) medulloblastoma, as evidenced by both in vitro and in vivo studies.
Wang B, Xu T, Qiu C, Yu L, Xu S, Zhao X, Xu C, Tan F, Sheng H, Zhang N
International immunopharmacology 2024 Dec 5;142(Pt A):113075
International immunopharmacology 2024 Dec 5;142(Pt A):113075
Long-term hypothermia amplified neuroprotection by antagonizing intracranial pressure rebound after severe traumatic brain injury in rats.
Sun X, Xu S, Wang J, Li X, Sun H, Zhao W
Neuroreport 2024 Dec 4;35(17):1107-1116
Neuroreport 2024 Dec 4;35(17):1107-1116
Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.
Yang Y, Shen J, Deng P, Chen P
Cancer biology & therapy 2024 Dec 31;25(1):2380023
Cancer biology & therapy 2024 Dec 31;25(1):2380023
miR-10b-5p promotes tumor growth by regulating cell metabolism in liver cancer via targeting SLC38A2.
Xia M, Chen J, Hu Y, Qu B, Bu Q, Shen H
Cancer biology & therapy 2024 Dec 31;25(1):2315651
Cancer biology & therapy 2024 Dec 31;25(1):2315651
MiR-490-3p promotes cell apoptosis and cell-cycle arrest in osteosarcoma via the modulation of CDCA8/ATF3 by targeting NUSAP1.
Wang H, Wang H, Liu Z, Wu P, Dai R, Hong D, Nakamura T, Ren W
Translational pediatrics 2024 Dec 31;13(12):2242-2253
Translational pediatrics 2024 Dec 31;13(12):2242-2253
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Huang X, Bao Y, Yang F, Li X, Wang F, Zhang C
Biology 2024 Dec 30;14(1)
Biology 2024 Dec 30;14(1)
Falcarindiol improves functional recovery and alleviates neuroinflammation after spinal cord injury by inhibiting STAT/MAPK signaling pathways.
Cao L, Huang X, Zhu J, Xiao J, Xie L
Biochemical and biophysical research communications 2024 Dec 3;736:150860
Biochemical and biophysical research communications 2024 Dec 3;736:150860
Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTOR signaling pathway.
Huang K, Fang J, Sun W, Zeng Y, Shi B, Ren B, Bi H, Shuai L
Scientific reports 2024 Dec 3;14(1):30099
Scientific reports 2024 Dec 3;14(1):30099
Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve.
Zhou Z, Li Y, Ding J, Sun S, Cheng W, Yu J, Cai Z, Ni Z, Yu C
Scientific reports 2024 Dec 28;14(1):30681
Scientific reports 2024 Dec 28;14(1):30681
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
Zheng Z, Zeng Y, Bao X, Huang C, Guo F, Xu F, Luo Z
Journal of experimental & clinical cancer research : CR 2024 Dec 26;43(1):330
Journal of experimental & clinical cancer research : CR 2024 Dec 26;43(1):330
The Pathogenic Role of Expanded CD8⁺CD28(null) Angiogenic T Cells in ANCA-Associated Vasculitis.
Shen H, Miao J, Sun H, Zhang K, Liu R, Li Z, Zhang L, Zhang P, Wang J, Zhang B, Chen L, Zheng Z, Zhu P
Biomedicines 2024 Dec 26;13(1)
Biomedicines 2024 Dec 26;13(1)
Curcumin activates the Wnt/β-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: A study based on network pharmacology and experimental verification.
He Y, Zhao Y, Lv RJ, Dong N, Wang X, Yu Q, Yue HM
International immunopharmacology 2024 Dec 25;143(Pt 1):113299
International immunopharmacology 2024 Dec 25;143(Pt 1):113299
Colorectal cancer cell-derived exosomal miRNA-372-5p induces immune escape from colorectal cancer via PTEN/AKT/NF-κB/PD-L1 pathway.
Wu Y, Xiao Y, Ding Y, Ran R, Wei K, Tao S, Mao H, Wang J, Pang S, Shi J, Zhu C, Wan W, Yang Q, Chen C
International immunopharmacology 2024 Dec 25;143(Pt 1):113261
International immunopharmacology 2024 Dec 25;143(Pt 1):113261
Excess Ub-K48 Induces Neuronal Apoptosis in Alzheimer's Disease.
Li Q, Yuan Y, Huang S, Di G, Chen H, Zhuang Y, Fang W, Huang Y, Tao Y, Jiang J, Xu Z
Journal of integrative neuroscience 2024 Dec 24;23(12):223
Journal of integrative neuroscience 2024 Dec 24;23(12):223
Ku70 silencing aggravates oxygen-glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes.
Xie X, Liu J
Histochemistry and cell biology 2024 Dec 23;163(1):20
Histochemistry and cell biology 2024 Dec 23;163(1):20
Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways.
Dong J, Wang Z, Fei F, Jiang Y, Jiang Y, Guo L, Liu K, Cui L, Meng X, Li J, Wang H
Veterinary sciences 2024 Dec 21;11(12)
Veterinary sciences 2024 Dec 21;11(12)
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Lin S, Li T, Zhang B, Wang P
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
Liu Y, Xu Y, Hao Q, Shi L, Chen Y, Liu Y, Li M, Zhang Y, Li T, Li Y, Jiang Z, Liu Y, Wang C, Bian Z, Yang L, Wang S
Cell death & disease 2024 Dec 20;15(12):921
Cell death & disease 2024 Dec 20;15(12):921
Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways.
Gong G, Chen X, Zhang X, Yin J, Wan W
Scientific reports 2024 Dec 20;14(1):30576
Scientific reports 2024 Dec 20;14(1):30576
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway.
Bao L, Wu Y, Ren Z, Huang Y, Jiang Y, Li K, Xu X, Ye Y, Gui Z
Biology direct 2024 Dec 19;19(1):139
Biology direct 2024 Dec 19;19(1):139
Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.
Li W, Lu M, Shang J, Zhou J, Lin L, Liu Y, Zhao D, Zhu X
Stem cell research & therapy 2024 Dec 18;15(1):484
Stem cell research & therapy 2024 Dec 18;15(1):484
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Qiu H, Gao L, Shi W, Wang J, Li B, Ke S, Chen J, Gong Y, Wu Y, Zhao W, Chen Y
Cancer letters 2024 Dec 16;611:217401
Cancer letters 2024 Dec 16;611:217401
Taxifolin attenuates hepatic ischemia-reperfusion injury by enhancing PINK1/Parkin-mediated mitophagy.
Zhang R, Fang Q, Yao L, Yu X, Liu X, Zhan M, Liu D, Yan Q, Du J, Chen L
European journal of pharmacology 2024 Dec 15;985:177100
European journal of pharmacology 2024 Dec 15;985:177100
Transcription factor PRRX1-activated ANXA6 facilitates EGFR-PKCα complex formation and enhances cisplatin sensitivity in bladder cancer.
Cao J, Chen S, Wang J, Fan X, Liu S, Li X, Yang L
Life sciences 2024 Dec 15;359:123228
Life sciences 2024 Dec 15;359:123228
Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression.
Zhou YC, Wang QQ, Zhou GY, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK
World journal of gastrointestinal oncology 2024 Dec 15;16(12):4700-4715
World journal of gastrointestinal oncology 2024 Dec 15;16(12):4700-4715
Prenatal exposure to environmentally relevant levels of PAHs inhibits spermatogenesis in adult mice and the mechanism involved.
Ou K, Zhang S, Lei X, Liu X, Zhang N, Wang C, Yuan X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124914
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124914
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
Fang P, Cheng S, Lai Y, Ma X, Lu K, Lu J, Li G, Yang E, Yang N, Gao W, Jiang R
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor.
Pu C, Liu Y, Lan S, Fan H, Liu L, Liu J, Guo Y
Bioorganic & medicinal chemistry 2024 Dec 1;115:117970
Bioorganic & medicinal chemistry 2024 Dec 1;115:117970
H(2)S-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K/AKT pathway.
Li H, Ma Q, Jia Y, Wang C, Wu J, Wang S, Hua H, Lu J, Li D
Bioorganic & medicinal chemistry 2024 Dec 1;115:117968
Bioorganic & medicinal chemistry 2024 Dec 1;115:117968
Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Wang Y, Yang J, Chang X, Xue Y, Liu G, Zhang T, Chen W, Fan W, Tian J, Ren X
Molecular nutrition & food research 2024 Aug;68(16):e2400215
Molecular nutrition & food research 2024 Aug;68(16):e2400215
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Gao C, Shang J, Sun Z, Xia M, Gao D, Sun R, Li W, Wang F, Zhang J
Molecular neurobiology 2024 Aug;61(8):5047-5070
Molecular neurobiology 2024 Aug;61(8):5047-5070
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
Lv S, Jiang H, Yu L, Zhang Y, Sun L, Xu J
Journal of molecular histology 2024 Aug;55(4):391-401
Journal of molecular histology 2024 Aug;55(4):391-401
Long noncoding RNA ANRIL alleviates hypoxia-induced pulmonary microvascular endothelial cell damage.
Qi Y, Chen M, Zhang T, Zhao B, Jin T, Yuan D
European journal of clinical investigation 2024 Aug;54(8):e14202
European journal of clinical investigation 2024 Aug;54(8):e14202
Digitoxin inhibits ICC cell properties via the NF‑κB/ST6GAL1 signaling pathway.
Zhan Y, Wang R, Huang C, Xu X, Xiao X, Wu L, Wei J, Long T, Gao C
Oncology reports 2024 Aug;52(2)
Oncology reports 2024 Aug;52(2)
Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells.
Liu X, Li R, Xiu Z, Tang S, Duan Y
Toxicology 2024 Aug;506:153861
Toxicology 2024 Aug;506:153861
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Neurochemical research 2024 Aug;49(8):2131-2147
Neurochemical research 2024 Aug;49(8):2131-2147
Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma.
Li L, Wei KL, Liu MS, Wang QL, Zeng TF, Chen RZ, Xia XW, Zhang HT
Photodiagnosis and photodynamic therapy 2024 Aug;48:104231
Photodiagnosis and photodynamic therapy 2024 Aug;48:104231
Mometasone furoate inhibits tumor progression and promotes apoptosis through activation of the AMPK/mTOR signaling pathway in osteosarcoma.
Li Z, Fei X, Pan Z, Liang Y, Yang Q, Cheng D
Journal of bone oncology 2024 Aug;47:100618
Journal of bone oncology 2024 Aug;47:100618
Succinylation of 14-3-3 theta by CPT1A promotes survival and paclitaxel resistance in nasal type extranodal natural killer/T-cell lymphoma.
Cui X, Cao C, Li X, Lin B, Yan A, Yang Y
Translational oncology 2024 Aug;46:102006
Translational oncology 2024 Aug;46:102006
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
Gu T, Wen Y, Zhou Q, Yuan W, Guo H, Chang WL, Yang Q
Mycotoxin research 2024 Aug;40(3):419-432
Mycotoxin research 2024 Aug;40(3):419-432
Downregulation of circ-RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3).
Cheng D, Chu F, Liang F, Zhang N, Wang J, Yue W
Environmental toxicology 2024 Aug;39(8):4249-4260
Environmental toxicology 2024 Aug;39(8):4249-4260
SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response.
Fu X, Duan Z, Lu X, Zhu Y, Ren Y, Zhang W, Sun X, Ge L, Yang J
Cancer biotherapy & radiopharmaceuticals 2024 Aug;39(6):425-434
Cancer biotherapy & radiopharmaceuticals 2024 Aug;39(6):425-434
miR-181d targets BCL2 to regulate HCT-8 cell apoptosis and parasite burden in response to Cryptosporidium parvum infection via the intrinsic apoptosis pathway.
Li J, Feng R, Zhang X, Hou W, Zhang Y, Li J, Li X, Jian F, Zhang L, Zhang S, Wang R
Veterinary parasitology 2024 Aug;330:110237
Veterinary parasitology 2024 Aug;330:110237
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
Pu Y, Yang J, Pan Q, Li C, Wang L, Xie X, Chen X, Xiao F, Chen G
The Journal of biological chemistry 2024 Aug;300(8):107530
The Journal of biological chemistry 2024 Aug;300(8):107530
Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration.
Dai C, Man Y, Zhang L, Zhang X, Xie C, Wang S, Zhang Y, Guo Q, Zou L, Hong H, Jiang L, Shi Y
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1211-1231
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1211-1231
Maintaining calcium homeostasis as a strategy to alleviate nephrotoxicity caused by evodiamine.
Yang CQ, Lai CC, Pan JC, Gao J, Shen BY, Ru Y, Shen X, Liu Y, Shen NN, Li BW, Wang YG, Gao Y
Ecotoxicology and environmental safety 2024 Aug;281:116563
Ecotoxicology and environmental safety 2024 Aug;281:116563
3,3'-Diindolylmethane inhibits the proliferation of esophageal squamous cell carcinoma cells via downregulation of STIM1.
Xiong C, Tang Y, Li F, Ye Y, Li X, Lin J, Dai S
Oncology letters 2024 Aug;28(2):339
Oncology letters 2024 Aug;28(2):339
SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1α.
Hui Y, Xia K, Zhong J, Zhang Y, Qiu Q, Chen Z, Wang L, Liu X
Journal of cellular and molecular medicine 2024 Aug;28(16):e70043
Journal of cellular and molecular medicine 2024 Aug;28(16):e70043
Age-related changes in the mitochondrial, synthesis of steroids, and cellular homeostasis of the chicken ovary.
Zhan XZ, Luo P, Zhang C, Zhang LJ, Shen X, Jiang DL, Liu WJ
Animal reproduction science 2024 Aug;267:107540
Animal reproduction science 2024 Aug;267:107540
Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway.
Deng ZH, Chen YX, Xue-Gao, Yang JY, Wei XY, Zhang GX, Qian JX
Biochemical pharmacology 2024 Aug;226:116382
Biochemical pharmacology 2024 Aug;226:116382
Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer.
Chen M, Liu Y, Li Y, Liu X
Acta biomaterialia 2024 Aug;184:368-382
Acta biomaterialia 2024 Aug;184:368-382
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Liang JH, Yu H, Xia CP, Zheng YH, Zhang Z, Chen Y, Raza MA, Wu L, Yan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Isorhamnetin improves diabetes-induced erectile dysfunction in rats through activation of the PI3K/AKT/eNOS signaling pathway.
Mao Y, Zha Y, Zang Y, Gao Y, Sun J, Liu Y, Wang Z, Wei Z, Wang M, Yang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116987
miR-200a-3p-enriched MSC-derived extracellular vesicles reverse erectile function in diabetic rats by targeting Keap1.
Zhang J, Zhao D, Zang Z, Ruan Z, Fu Q, Zhang K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116964
Novel meroterpene-like compounds inhibit ferroptosis through Fe(2+) chelation.
Lou S, Liu YX, Xia C, Zhang Q, Deng L, Tang JJ
The international journal of biochemistry & cell biology 2024 Aug;173:106610
The international journal of biochemistry & cell biology 2024 Aug;173:106610
MiR-23b-3p alleviates Sjögren's syndrome by targeting SOX6 and inhibiting the NF-κB signaling.
Cai Y, Zhang Y, Wang S, Changyong E
Molecular immunology 2024 Aug;172:68-75
Molecular immunology 2024 Aug;172:68-75
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Zhu G, Li Y, Gao H, Li X, Fan H, Fan L
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
N-acetylcysteine stimulates the proliferation and differentiation in heat-stressed skeletal muscle cells.
Lu J, Zhao P, Ding X, Li H
Journal of thermal biology 2024 Aug;124:103958
Journal of thermal biology 2024 Aug;124:103958
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Canadine Platinum(IV) Complexes Targeting Epithelial-Mesenchymal Transition as Antiproliferative and Antimetastatic Agents.
Chen Y, Zhang M, He Y, Li S, Feng S, Liu Z, Zhang N, Liu M, Wang Q
Journal of medicinal chemistry 2024 Aug 8;67(15):12868-12886
Journal of medicinal chemistry 2024 Aug 8;67(15):12868-12886
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.
Hao EJ, Zhao Y, Yu M, Li XJ, Wang KX, Su FY, Liang YR, Wang Y, Guo HM
Journal of medicinal chemistry 2024 Aug 8;67(15):12553-12570
Journal of medicinal chemistry 2024 Aug 8;67(15):12553-12570
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Wang Y, Gong J, Heng N, Hu Y, Wang R, Wang H, He W, Zhu N, Hu Z, Hao H, Zhu H, Zhao S
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
The Effects of trans-10, cis-12 Conjugated Linoleic Acid on the Production Performance of Dairy Cows and the Expression and Transcription Regulation of Lipid Metabolism-Related Genes in Bovine Mammary Epithelial Cells.
Guo Y, Wei Z, Zhang Y, Cao J
ACS omega 2024 Aug 6;9(31):34161-34174
ACS omega 2024 Aug 6;9(31):34161-34174
Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone.
Yu Y, Qin X, Chen X, Nie H, Li J, Yao J
Biochemical and biophysical research communications 2024 Aug 6;720:150065
Biochemical and biophysical research communications 2024 Aug 6;720:150065
Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.
Chen W, Yang KB, Zhang YZ, Lin ZS, Chen JW, Qi SF, Wu CF, Feng GK, Yang DJ, Chen M, Zhu XF, Li X
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Journal of experimental & clinical cancer research : CR 2024 Aug 30;43(1):248
Bacillus subtilis alleviates excessive apoptosis of intestinal epithelial cells in intrauterine growth restriction suckling piglets via the members of Bcl-2 and caspase families.
Xie Z, Yun Y, Yu G, Zhang X, Zhang H, Wang T, Zhang L
Journal of the science of food and agriculture 2024 Aug 30;104(11):6924-6932
Journal of the science of food and agriculture 2024 Aug 30;104(11):6924-6932
Synergistic effects of plasma-activated medium in combination with Baicalin against neuronal damage.
Zhu J, Liu Q, Chen Y, Zhang J, Xu Q, Wu Z
Heliyon 2024 Aug 30;10(16):e36079
Heliyon 2024 Aug 30;10(16):e36079
Gastrin-related circRNA_0017065 promotes the proliferation and metastasis of colorectal cancer through the miR-3174/RBFOX2 axis.
Wang X, Sun T, Fan J, Zuo X, Mao J
Biology direct 2024 Aug 29;19(1):75
Biology direct 2024 Aug 29;19(1):75
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Li J, Liu Q, Liu S, Xin H, Zhang X, Guo N
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Revealing the Mechanism of Esculin in Treating Renal Cell Carcinoma Based on Network Pharmacology and Experimental Validation.
Chen Z, Wang C, Cai Y, Xu A, Han C, Tong Y, Cheng S, Liu M
Biomolecules 2024 Aug 22;14(8)
Biomolecules 2024 Aug 22;14(8)
Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage.
Kan T, Li H, Hou L, Cui J, Wang Y, Sun L, Wang L, Yan M, Yu Z
iScience 2024 Aug 16;27(8):110507
iScience 2024 Aug 16;27(8):110507
Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis.
Wang X, Tang P, Gong Y, Yao H, Liang M, Qu H, Han X, Zheng Q, Shi Z, Li D, Jiang Q
iScience 2024 Aug 16;27(8):110382
iScience 2024 Aug 16;27(8):110382
CCR5 antagonist maraviroc alleviates doxorubicin-induced neuroinflammation and neurobehavioral deficiency by regulating NF-κB/NLRP3 signaling in a breast cancer mouse model.
Wu Y, Che J, Dong J, Zhang X, Deng Y, Chen W, Zhang J
Neuropharmacology 2024 Aug 15;254:109981
Neuropharmacology 2024 Aug 15;254:109981
2,3-Diphosphoglyceric Acid Alleviating Hypoxic-Ischemic Brain Damage through p38 MAPK Modulation.
Ni J, Zhao J, Chen H, Liu W, Le M, Guo X, Dong X
International journal of molecular sciences 2024 Aug 15;25(16)
International journal of molecular sciences 2024 Aug 15;25(16)
Effect of acacetin on inhibition of apoptosis in Helicobacter pylori-infected gastric epithelial cell line.
Yao QX, Li ZY, Kang HL, He X, Kang M
World journal of gastrointestinal oncology 2024 Aug 15;16(8):3624-3634
World journal of gastrointestinal oncology 2024 Aug 15;16(8):3624-3634
MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma.
Cao L, Jing X, Liu L, Wang H, Zhu J, Zhou J, Peng H, Zhang J, Li F, Wang X, Zhao L
Heliyon 2024 Aug 15;10(15):e35695
Heliyon 2024 Aug 15;10(15):e35695
Exploration of the mechanism of fraxetin in treating acute myeloid leukemia based on network pharmacology and experimental verification.
Chai Y, Sun X, Zhou Q, Li H, Xi Y
Heliyon 2024 Aug 15;10(15):e34717
Heliyon 2024 Aug 15;10(15):e34717
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
Ji R, Hao Z, Wang H, Su Y, Yang W, Li X, Duan L, Guan F, Ma S
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17964-17976
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17964-17976
Mitochondria-Targeted Multifunctional Nanoprodrugs by Inhibiting Metabolic Reprogramming for Combating Cisplatin-Resistant Lung Cancer.
Lu H, Tong W, Jiang M, Liu H, Meng C, Wang K, Mu X
ACS nano 2024 Aug 13;18(32):21156-21170
ACS nano 2024 Aug 13;18(32):21156-21170
Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics.
Hu B, Wang C, Wu Y, Han C, Liu J, Chen R, Wang T
Journal of ethnopharmacology 2024 Aug 10;330:118228
Journal of ethnopharmacology 2024 Aug 10;330:118228
Leonurus japonicus Houtt. modulates neuronal apoptosis in intracerebral hemorrhage: Insights from network pharmacology and molecular docking.
Wu JW, Gao W, Shen LP, Chen YL, Du SQ, Du ZY, Zhao XD, Lu XJ
Journal of ethnopharmacology 2024 Aug 10;330:118223
Journal of ethnopharmacology 2024 Aug 10;330:118223
FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway.
Cheng F, Wang J, Wang R, Pan R, Cui Z, Wang L, Wang L, Yang X
Molecular and cellular endocrinology 2024 Aug 1;589:112248
Molecular and cellular endocrinology 2024 Aug 1;589:112248
Dihydrocelastrol induces cell death and suppresses angiogenesis through BCR/AP-1/junb signalling in diffuse large B cell lymphoma.
Lai Y, Guo S, Tang Q, Chang G, Zhang H, Li B, Feng Q, Hu K, Xu Z, Gao X, Zhang Q, Yi H, Song D, Zhang Y, Peng Y, Cai H, Zhu W, Shi J
Archives of biochemistry and biophysics 2024 Apr;754:109929
Archives of biochemistry and biophysics 2024 Apr;754:109929
Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis.
Wei W, Zhao G, Li Q, Zhang J, Wei H, Shen C, Zhao B, Ji Z, Wang L, Guo Y, Jin P
Aesthetic plastic surgery 2024 Apr;48(7):1473-1486
Aesthetic plastic surgery 2024 Apr;48(7):1473-1486
A novel 2-iminobenzimidazole compound, XYA1353, displays in vitro and in vivo anti-myeloma activity via targeting NF-κB signaling.
Gao J, Zhou J, Zhang M, Zhang Y, Zeng Y, Li S, Xu K, Yao R
Molecular and cellular biochemistry 2024 Apr;479(4):843-857
Molecular and cellular biochemistry 2024 Apr;479(4):843-857
LncRNA LOXL1-AS1 promotes proliferation and invasion and inhibits apoptosis in retinoblastoma by regulating the MAPK signaling pathway.
Wu W, Zhang Y, Xu C, Yang H, Liu S, Huang G
Molecular and cellular biochemistry 2024 Apr;479(4):1011-1022
Molecular and cellular biochemistry 2024 Apr;479(4):1011-1022
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Wang N, Guo W, Liu T, Chen X, Lin M
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
Biotechnology & genetic engineering reviews 2024 Apr;40(1):519-539
IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
Wang J, Wu Z, Huang Y, Jin L, Xu J, Yao Z, Ouyang X, Zhou Z, Mao S, Cao J, Lai B, Shen W
Environmental toxicology 2024 Apr;39(4):2390-2404
Environmental toxicology 2024 Apr;39(4):2390-2404
Pimpinellin ameliorates macrophage inflammation by promoting RNF146-mediated PARP1 ubiquitination.
Yang L, Du M, Liu K, Wang P, Zhu J, Li F, Wang Z, Huang K, Liang M
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Phytotherapy research : PTR 2024 Apr;38(4):1783-1798
Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro.
Zuo Z, Li Q, Zhou S, Yu R, Wu C, Chen J, Xiao Y, Chen H, Song J, Pan Y, Wang W
Phytotherapy research : PTR 2024 Apr;38(4):1761-1780
Phytotherapy research : PTR 2024 Apr;38(4):1761-1780
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers.
Li L, Zhong G, Li Y, Li T, Huo Y, Ma F, Li Y, Zhang H, Pan J, Hu L, Liao J, Tang Z
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2024 Apr;37(2):421-432
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2024 Apr;37(2):421-432
Nicotine suppresses crystalline silica-induced astrocyte activation and neuronal death by inhibiting NF-κB in the mouse hippocampus.
Cao H, Li B, Mu M, Li S, Chen H, Tao H, Wang W, Zou Y, Zhao Y, Liu Y, Tao X
CNS neuroscience & therapeutics 2024 Apr;30(4):e14508
CNS neuroscience & therapeutics 2024 Apr;30(4):e14508
Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet.
Xiao G, Wei Y, Xie R, Tsang Y, Gu J, Shen D, Ding M, Yuan J, Xu D, Fei J
The FEBS journal 2024 Apr;291(8):1699-1718
The FEBS journal 2024 Apr;291(8):1699-1718
Investigation of GPR143 as a promising novel marker for the progression of skin cutaneous melanoma through bioinformatic analyses and cell experiments.
Bai R, Yin P, Xing Z, Wu S, Zhang W, Ma X, Gan X, Liang Y, Zang Q, Lei H, Wei Y, Zhang C, Dai B, Zheng Y
Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):372-392
Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):372-392
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
Li X, Li B, Meng X, Yu F, Yu X, Zhao W, Wang Y, Gao H, Cheng M, Zhong L
Journal of medicinal food 2024 Apr;27(4):312-329
Journal of medicinal food 2024 Apr;27(4):312-329
Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection.
Xue S, Leng S, Zhang F, Dang Z, Su G, Yu W
Experimental and therapeutic medicine 2024 Apr;27(4):145
Experimental and therapeutic medicine 2024 Apr;27(4):145
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease.
Cao G, Kang T, Li N, Li P
Experimental and therapeutic medicine 2024 Apr;27(4):135
Experimental and therapeutic medicine 2024 Apr;27(4):135
Chloroxine inhibits pancreatic cancer progression through targeted antagonization of the PI3K/AKT/mTOR signaling pathway.
Lin M, Xiao Y, Dai Y, Mao Y, Xu L, Zhang Q, Chen Z
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Apr;26(4):951-965
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Apr;26(4):951-965
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110
Biochemical pharmacology 2024 Apr;222:116110
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Zhou Q, Shi D, Tang YD, Zhang L, Hu B, Zheng C, Huang L, Weng C
PLoS pathogens 2024 Apr;20(4):e1012146
PLoS pathogens 2024 Apr;20(4):e1012146
Mn-Anti-CTLA4-CREKA-Sericin Nanotheragnostics for Enhanced Magnetic Resonance Imaging and Tumor Immunotherapy.
Huang Z, Wang Y, Su C, Li W, Wu M, Li W, Wu J, Xia Q, He H
Small (Weinheim an der Bergstrasse, Germany) 2024 Apr;20(15):e2306912
Small (Weinheim an der Bergstrasse, Germany) 2024 Apr;20(15):e2306912
STAT3 ameliorates truncated tau-induced cognitive deficits.
Zhang B, Wan H, Maierwufu M, Liu Q, Li T, He Y, Wang X, Liu G, Hong X, Feng Q
Neural regeneration research 2024 Apr;19(4):915-922
Neural regeneration research 2024 Apr;19(4):915-922
Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling.
Du C, Zhao S, Shan T, Han X, Jiang Q, Chen J, Gu L, Wei T, Yang T, Wang S, Wang H, Guo X, Wang L
Journal of molecular and cellular cardiology 2024 Apr;189:66-82
Journal of molecular and cellular cardiology 2024 Apr;189:66-82
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Yang N, Yu G, Lai Y, Zhao J, Chen Z, Chen L, Fu Y, Fang P, Gao W, Cai Y, Li Z, Xiao J, Zhou K, Ding J
British journal of pharmacology 2024 Apr;181(7):1068-1090
British journal of pharmacology 2024 Apr;181(7):1068-1090
Histone deacetylase 9-mediated phenotypic transformation of vascular smooth muscle cells is a potential target for treating aortic aneurysm/dissection.
Dang Z, Li H, Xue S, Shao B, Ning Y, Su G, Zhang F, Yu W, Leng S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116396
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116396
Human amniotic mesenchymal stromal cell-derived exosomes promote neuronal function by inhibiting excessive apoptosis in a hypoxia/ischemia-induced cerebral palsy model: A preclinical study.
Zhou Y, He LN, Wang LN, Chen KY, Qian SD, Li XH, Zang J, Wang DM, Yu XF, Gao J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116321
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116321
Triphenylphosphonium-linked derivative of hecogenin with enhanced antiproliferative activity: Design, synthesis, and biological evaluation.
Zhang J, Zhu W, Ma Y, Huang X, Su W, Sun Y, Liu Q, Ma T, Ma L, Sun J, Fan S, Wang X, Lin S, Wang W, Han C
Bioorganic chemistry 2024 Apr;145:107210
Bioorganic chemistry 2024 Apr;145:107210
Knocking down GRAMD1C expression reduces 6-OHDA-induced apoptosis in PC12 cells.
He H, Zhang B, Wang X, Chen L
Toxicology research 2024 Apr;13(2):tfae051
Toxicology research 2024 Apr;13(2):tfae051
Regulatory mechanism of perinatal nonylphenol exposure on cardiac mitochondrial autophagy and the PINK1/Parkin signaling pathway in male offspring rats.
Yang X, Xu J, Xu Y, Wang C, Lin F, Yu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155434
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155434
Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy-Ferroptosis Combined Therapy for Gastric Cancer.
Sun B, Zheng X, Zhang X, Zhang H, Jiang Y
ACS omega 2024 Apr 9;9(14):16676-16686
ACS omega 2024 Apr 9;9(14):16676-16686
NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16.
Guo D, Zhang M, Wei T, Zhang X, Shi X, Tang H, Ding M, Li J, Zhang S, Guo W
Cellular and molecular life sciences : CMLS 2024 Apr 6;81(1):167
Cellular and molecular life sciences : CMLS 2024 Apr 6;81(1):167
Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells.
Liu M, Lu J, Hu J, Chen Y, Deng X, Wang J, Zhang S, Guo J, Li W, Guan S
Journal of hazardous materials 2024 Apr 5;467:133719
Journal of hazardous materials 2024 Apr 5;467:133719
Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
Fan Y, Zhang W, Huang X, Fan M, Shi C, Zhao L, Pi G, Zhang H, Ni S
Nature communications 2024 Apr 5;15(1):2939
Nature communications 2024 Apr 5;15(1):2939
Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.
Guo L, Yue M, Ma C, Wang Y, Hou J, Li H
Heliyon 2024 Apr 30;10(8):e29361
Heliyon 2024 Apr 30;10(8):e29361
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.
Liu H, Zheng Y, Kan S, Hao M, Jiang H, Li S, Li R, Wang Y, Wang D, Liu W
Heliyon 2024 Apr 30;10(8):e29291
Heliyon 2024 Apr 30;10(8):e29291
The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis.
Wen E, Cao Y, He S, Zhang Y, You L, Wang T, Wang Z, He J, Feng Y
Journal of nanobiotechnology 2024 Apr 3;22(1):148
Journal of nanobiotechnology 2024 Apr 3;22(1):148
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.
Yang L, Ruan Y, Xu H
BMC cancer 2024 Apr 29;24(1):544
BMC cancer 2024 Apr 29;24(1):544
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y
Cancer letters 2024 Apr 28;588:216802
Cancer letters 2024 Apr 28;588:216802
Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.
He Y, Jiang S, Cui Y, Liang J, Zhong Y, Sun Y, Moran MF, Huang Z, He G, Mao X
Cancer letters 2024 Apr 28;588:216797
Cancer letters 2024 Apr 28;588:216797
Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.
Xu ZH, Dang Y, Dong Y, Dong CY, Liu Y, Chen X, Yao Z, Shi JP
Journal of ethnopharmacology 2024 Apr 24;324:117758
Journal of ethnopharmacology 2024 Apr 24;324:117758
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
Deng X, Ren J, Chen K, Zhang J, Zhang Q, Zeng J, Li T, Tang Q, Lin J, Zhu J
Journal of neuroinflammation 2024 Apr 24;21(1):106
Journal of neuroinflammation 2024 Apr 24;21(1):106
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway.
Zhang F, Cui M, Zhang L, Ma B, Guo F, Wang G
Pediatric research 2024 Apr 24;
Pediatric research 2024 Apr 24;
Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer.
Li XQ, Cheng XJ, Wu J, Wu KF, Liu T
Cellular & molecular biology letters 2024 Apr 23;29(1):58
Cellular & molecular biology letters 2024 Apr 23;29(1):58
Icariin ameliorates LPS-induced acute lung injury in mice via complement C5a-C5aR1 and TLR4 signaling pathways.
Guo J, Zhang QY, Xu L, Li M, Sun QY
International immunopharmacology 2024 Apr 20;131:111802
International immunopharmacology 2024 Apr 20;131:111802
6-Gingerol attenuates hepatic ischemia/reperfusion injury through regulating MKP5-mediated P38/JNK pathway.
Yu Q, Li J, Cui M, Mei C, He Q, Du X
Scientific reports 2024 Apr 2;14(1):7747
Scientific reports 2024 Apr 2;14(1):7747
B-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer.
Hui YJ, Yu TT, Li LG, Peng XC, Di MJ, Liu H, Gu WL, Li TF, Zhao KL, Wang WX
Scientific reports 2024 Apr 2;14(1):7733
Scientific reports 2024 Apr 2;14(1):7733
Acupuncture Extended the Thrombolysis Window by Suppressing Blood-Brain Barrier Disruption and Regulating Autophagy-Apoptosis Balance after Ischemic Stroke.
Zhang Z, Lu T, Li S, Zhao R, Li H, Zhang X, Li Y, Xia Y, Ni G
Brain sciences 2024 Apr 19;14(4)
Brain sciences 2024 Apr 19;14(4)
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
TDCPP and TiO(2) NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.
Wang L, Wang B, Zhang X, Yang Z, Zhang X, Gong H, Song Y, Zhang K, Sun M
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123740
BMSCs attenuate radiation-induced brain injury induced hippocampal neuronal apoptosis through a PI3K/Akt/Bax/Bcl-2 signaling pathway.
Xu K, Liu Z, Pan S, Zhang N, Wu S, Yang G, Song X, Teng Y, Tong X
Brain research 2024 Apr 15;1829:148795
Brain research 2024 Apr 15;1829:148795
Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis.
Peng Y, Guo M, Luo M, Lv D, Liao K, Luo S, Zhang B
Heliyon 2024 Apr 15;10(7):e29160
Heliyon 2024 Apr 15;10(7):e29160
Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage.
Yang C, Jiang Z, Gao X, Yang H, Su J, Weng R, Ni W, Gu Y
Amino acids 2024 Apr 14;56(1):31
Amino acids 2024 Apr 14;56(1):31
Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson's disease.
Guo Q, Wang Y, Yu L, Guan L, Ji X, Li X, Pang G, Ren Z, Ye L, Cheng H
Journal of translational medicine 2024 Apr 12;22(1):350
Journal of translational medicine 2024 Apr 12;22(1):350
Rat Hepatocytes Protect against Lead-Cadmium-Triggered Apoptosis Based on Autophagy Activation.
Xue J, Liu H, Yin T, Zhou X, Song X, Zou Y, Li L, Jia R, Fu Y, Zhao X, Yin Z
Toxics 2024 Apr 12;12(4)
Toxics 2024 Apr 12;12(4)
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.
Sun M, Chang H, Jiang F, Zhang W, Yang Q, Wang X, Lv G, Lin H, Luo H, Lin Z, Wang Y
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)
Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
Luo P, An Y, He J, Xing X, Zhang Q, Liu X, Chen Y, Yuan H, Chen J, Wong YK, Huang J, Gong Z, Du Q, Xiao W, Wang J
Cancer letters 2024 Apr 10;587:216621
Cancer letters 2024 Apr 10;587:216621
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Dong M, Yang Z, Gao Q, Deng Q, Li L, Chen H
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
Wang N, Zhang Q, Wang Z, Liu Y, Yang S, Zhao X, Peng J
Carbohydrate polymers 2024 Apr 1;329:121795
Carbohydrate polymers 2024 Apr 1;329:121795
Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome.
Jiao B, Zhang H, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y
Ecotoxicology and environmental safety 2024 Apr 1;274:116174
Ecotoxicology and environmental safety 2024 Apr 1;274:116174
Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis.
Huo D, Liang W, Wang D, Liu Q, Wang H, Wang Y, Zhang C, Cong C, Su X, Tan X, Zhang W, Han L, Zhang D, Wang M, Feng H
Neuropharmacology 2024 Apr 1;247:109812
Neuropharmacology 2024 Apr 1;247:109812
Construction and validation of a hypoxia-related gene signature to predict the prognosis of breast cancer.
Qiu C, Wang W, Xu S, Li Y, Zhu J, Zhang Y, Lei C, Li W, Li H, Li X
BMC cancer 2024 Apr 1;24(1):402
BMC cancer 2024 Apr 1;24(1):402
CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression.
Ju L, Luo Y, Cui X, Zhang H, Chen L, Yao M
Scientific reports 2024 Apr 1;14(1):7632
Scientific reports 2024 Apr 1;14(1):7632
Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate.
Cao W, Lu X, Zhong C, Wu J
Nutrition and cancer 2023;75(3):980-991
Nutrition and cancer 2023;75(3):980-991
Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog.
Zhang T, Cao W, Sun H, Yu D, Zhong C
Nutrition and cancer 2023;75(3):971-979
Nutrition and cancer 2023;75(3):971-979
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells.
He NN, Wang JA, Huang D, Sun XL, Ding F, Zhao L, Zhang YX, Li HM, Wu CZ
Chemical & pharmaceutical bulletin 2023;71(11):798-803
Chemical & pharmaceutical bulletin 2023;71(11):798-803
Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
Ji L, Shi X, Wang G, Wu H, Hu Z
Folia histochemica et cytobiologica 2023;61(1):34-46
Folia histochemica et cytobiologica 2023;61(1):34-46
Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts from Sanghuangporusvaninii.
Gao H, Yin C, Li C, Li Y, Shi D, Fan X, Yao F, Wu W, Li J
Current research in food science 2023;6:100519
Current research in food science 2023;6:100519
Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal.
Xia K, Wang T, Chen Z, Guo J, Yu B, Chen Q, Qiu T, Zhou J, Zheng S
Research (Washington, D.C.) 2023;6:0256
Research (Washington, D.C.) 2023;6:0256
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Pileggi CA, Parmar G, Elkhatib H, Stewart CM, Alecu I, Côté M, Bennett SAL, Sandhu JK, Cuperlovic-Culf M, Harper ME
Current research in neurobiology 2023;5:100112
Current research in neurobiology 2023;5:100112
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Zhou H, Xu L, Shi Y, Gu S, Wu N, Liu F, Huang Y, Qian Z, Xue W, Wang X, Chen F
Biological & pharmaceutical bulletin 2023;46(1):42-51
Biological & pharmaceutical bulletin 2023;46(1):42-51
Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway.
Zhang D, Shen F, Ma S, Nan S, Ma Y, Ren L, Li H, Yu Q
Iranian journal of basic medical sciences 2023;26(6):653-661
Iranian journal of basic medical sciences 2023;26(6):653-661
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
Lu Y, Zi C, Zhang L, Cui B, Li L, Ma J
Combinatorial chemistry & high throughput screening 2023;26(6):1204-1213
Combinatorial chemistry & high throughput screening 2023;26(6):1204-1213
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Liu N, Fan Y, Li Y, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y, Yang X
Current neuropharmacology 2023;21(12):2550-2562
Current neuropharmacology 2023;21(12):2550-2562
MiR-125b-5p/STAT3 Axis Regulates Drug Resistance in Osteosarcoma Cells by Acting on ABC Transporters.
Yang Y, Chen Y, Liu J, Zhang B, Yang L, Xue J, Zhang Z, Qin L, Bian R
Stem cells international 2023;2023:9997676
Stem cells international 2023;2023:9997676
Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway.
Yu J, Zhao Y, Xu L, Li W, Zhang H, Ping F, Li Y
Mediators of inflammation 2023;2023:8974960
Mediators of inflammation 2023;2023:8974960
Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells.
Wu X, Wang A, Xu L, Li M, Zhai Q, Wang W, Li C, Jin L
Cardiovascular therapeutics 2023;2023:8817431
Cardiovascular therapeutics 2023;2023:8817431
Study on Neuroprotective Mechanism of Houshiheisan in Ischemic Stroke Based on Transcriptomics and Experimental Verification.
Cheng H, Zhang Y, Guo X, Wang X, Wang H, Zhao H, Wang L, Zou H, Zhang Q
Evidence-based complementary and alternative medicine : eCAM 2023;2023:8673136
Evidence-based complementary and alternative medicine : eCAM 2023;2023:8673136
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
Duan SF, Zhang MM, Dong Q, Yang B, Liu W, Zhang X, Yu HL, Zhang SH, Khan NH, Wu DD, Zhang XJ, Cen J
Journal of oncology 2023;2023:8456852
Journal of oncology 2023;2023:8456852
P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD(+)/Sirt3 Pathway.
Wu Y, Hu Q, Wu X, Cai YN, Zhang YZ, Wu YX, Zhu G, Luo JN, Cheng HB, Yu JG, Wang XL, Gao L, Gao GD
Oxidative medicine and cellular longevity 2023;2023:7857760
Oxidative medicine and cellular longevity 2023;2023:7857760
Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.
Chi B, Zou A, Mao L, Cai D, Xiao T, Wang Y, Wang Q, Ji Y, Sun L
Oxidative medicine and cellular longevity 2023;2023:7747727
Oxidative medicine and cellular longevity 2023;2023:7747727
miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R.
Huang Z, Luo Y, Chen C, Zhou C, Su Z, Cai C, Li X, Wu W
Canadian journal of gastroenterology & hepatology 2023;2023:6882851
Canadian journal of gastroenterology & hepatology 2023;2023:6882851
Mini-αA Upregulates the miR-155-5p Target Gene CDK2 and Plays an Antiapoptotic Role in Retinal Pigment Epithelial Cells during Oxidative Stress.
Chen Q, Lin H, Li S, Deng X, Zhang J
Journal of ophthalmology 2023;2023:6713094
Journal of ophthalmology 2023;2023:6713094
Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage.
Du N, Zhang B, Zhang Y
Canadian respiratory journal 2023;2023:4533504
Canadian respiratory journal 2023;2023:4533504
Exosomes from Adipose-Derived Stem Cells Alleviate Dexamethasone-Induced Bone Loss by Regulating the Nrf2/HO-1 Axis.
Yao XW, Liu ZY, Ma NF, Jiang WK, Zhou Z, Chen B, Guan WG, Yan JJ, Yang M
Oxidative medicine and cellular longevity 2023;2023:3602962
Oxidative medicine and cellular longevity 2023;2023:3602962
Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
Zhengbiao Z, Liang C, Zhi Z, Youmin P
Computational and mathematical methods in medicine 2023;2023:1318817
Computational and mathematical methods in medicine 2023;2023:1318817
Resveratrol Suppresses Bupivacaine-Induced Spinal Neurotoxicity in Rats by Inhibiting Endoplasmic Reticulum Stress via SIRT1 Modulation.
Luo Y, Zhao Y, Lai J, Wei L, Zhou G, Yu Y, Liu J
BioMed research international 2023;2023:1176232
BioMed research international 2023;2023:1176232
Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells.
Zhu L, Yao Z, Luo Q, Liu Y, Zhao W, Shao C, Shao S, Cui F
International journal of medical sciences 2023;20(8):1038-1045
International journal of medical sciences 2023;20(8):1038-1045
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Li S, Liu H, Liu W, Shi N, Zhao M, Wanggou S, Luo W, Wang L, Zhu B, Zuo X, Xie W, Zhao C, Zhou Y, Luo L, Gao X, Jiang X, Ren C
International journal of biological sciences 2023;19(3):916-935
International journal of biological sciences 2023;19(3):916-935
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Xu WN, Liu C, Zheng HL, Xu HX, Yang RZ, Jiang SD, Zhu LX
International journal of biological sciences 2023;19(2):571-592
International journal of biological sciences 2023;19(2):571-592
Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis.
Zhang GH, Chin KL, Yan SY, Pare R
PloS one 2023;18(10):e0287817
PloS one 2023;18(10):e0287817
Bacterial lipoprotein plays an important role in the macrophage autophagy and apoptosis induced by Salmonella typhimurium and Staphylococcus aureus.
Jiang S, He J, Zhang L, Zhao Q, Zhao S
Open life sciences 2023;18(1):20220739
Open life sciences 2023;18(1):20220739
Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway.
Tang X, Guo Y, Zhang S, Wang X, Teng Y, Jin Q, Jin Q, Shen W, Wang R
Drug design, development and therapy 2023;17:389-402
Drug design, development and therapy 2023;17:389-402
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88.
Luan C, Lu Z, Chen J, Chen M, Zhao R, Li X
Drug design, development and therapy 2023;17:2821-2839
Drug design, development and therapy 2023;17:2821-2839
Fenofibrate Attenuates Renal Tubular Cell Apoptosis by Up-Regulating MCAD in Diabetic Kidney Disease.
Tang C, Deng X, Qu J, Miao Y, Tian L, Zhang M, Li X, Sun B, Chen L
Drug design, development and therapy 2023;17:1503-1514
Drug design, development and therapy 2023;17:1503-1514
Neuroplastin 65 deficiency reduces amyloid plaque formation and cognitive deficits in an Alzheimer's disease mouse model.
Wu DD, Cheng J, Zheng YN, Liu YT, Hou SX, Liu LF, Huang L, Yuan QL
Frontiers in cellular neuroscience 2023;17:1129773
Frontiers in cellular neuroscience 2023;17:1129773
Esomeprazole Alleviates Cisplatin Resistance by Inhibiting the AKT/mTOR Pathway in Ovarian Cancer Cells.
Duan J, Zhang Z, Du J, Zhang J, Li M, Li C
OncoTargets and therapy 2023;16:425-440
OncoTargets and therapy 2023;16:425-440
NEK6 Promotes the Progression of Osteosarcoma Through Activating STAT3 Signaling Pathway by Down-Regulation of miR-26a-5p.
Zhu M, Sun Y, Xue H, Wu G, Wang Z, Shi J, Ma J, Gu B, Yan X
International journal of general medicine 2023;16:2831-2848
International journal of general medicine 2023;16:2831-2848
MALAT1 knockdown alleviates myocardial injury in mice with severe acute pancreatitis via the miR-374a/Sp1/Wnt/β-catenin pathway.
Sun Y, Gu R, Shen Z, Ye Y
American journal of translational research 2023;15(6):3928-3941
American journal of translational research 2023;15(6):3928-3941
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Zhang T, Liu MQ, Xie GS, Wu DM, Luo PW, Liu T, Deng SH, Wang YY, He S, Zhou Y, Zhou J, Xu Y
Journal of Cancer 2023;14(8):1350-1361
Journal of Cancer 2023;14(8):1350-1361
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Wang Y, He Q, Rong K, Zhu M, Zhao X, Zheng P, Mi Y
Frontiers in pharmacology 2023;14:1338260
Frontiers in pharmacology 2023;14:1338260
Integration of RRBS and RNA-seq unravels the regulatory role of DNMT3A in porcine Sertoli cell proliferation.
Xu D, Yan S, Jin H, Chen C, Tang X, Wang X, Li Y, Fei F, Yang A
Frontiers in genetics 2023;14:1302351
Frontiers in genetics 2023;14:1302351
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Yang HW, Lan Y, Li A, Wu H, Song ZW, Wan AL, Wang Y, Li SB, Ji S, Wang ZC, Wu XY, Lan T
Frontiers in pharmacology 2023;14:1288883
Frontiers in pharmacology 2023;14:1288883
18-α-glycyrrhetinic acid alleviates oxidative damage in periodontal tissue by modulating the interaction of Cx43 and JNK/NF-κB pathways.
Cao N, Liu X, Hou Y, Deng Y, Xin Y, Xin X, Xiang X, Liu X, Yu W
Frontiers in pharmacology 2023;14:1221053
Frontiers in pharmacology 2023;14:1221053
Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling.
Wu L, Lin Y, Gao S, Wang Y, Pan H, Wang Z, Pozzolini M, Yang F, Zhang H, Yang Y, Xiao L, Xu Y
Frontiers in pharmacology 2023;14:1200843
Frontiers in pharmacology 2023;14:1200843
Pterostilbene attenuates microglial inflammation and brain injury after intracerebral hemorrhage in an OPA1-dependent manner.
Wu Y, Hu Q, Wang X, Cheng H, Yu J, Li Y, Luo J, Zhang Q, Wu J, Zhang G
Frontiers in immunology 2023;14:1172334
Frontiers in immunology 2023;14:1172334
The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats.
Ma P, Huang N, Tang J, Zhou Z, Xu J, Chen Y, Zhang M, Huang Q, Cheng Y
Frontiers in pharmacology 2023;14:1098228
Frontiers in pharmacology 2023;14:1098228
Adjuvant therapy with Huatan Sanjie Granules improves the prognosis of patients with primary liver cancer: a cohort study and the investigation of its mechanism of action based on network pharmacology.
Yuan J, Abdurahman A, Cui N, Hao T, Zou J, Liu L, Wu Y
Frontiers in pharmacology 2023;14:1091177
Frontiers in pharmacology 2023;14:1091177
Promotion of colorectal cancer cell death by ezetimibe via mTOR signaling-dependent mitochondrial dysfunction.
Zheng Y, Yang W, Jia Y, Ji J, Wu L, Feng J, Li Y, Cheng Z, Zhang J, Li J, Dai W, Xu X, Wu J, Zhou Y, Guo C
Frontiers in pharmacology 2023;14:1081980
Frontiers in pharmacology 2023;14:1081980
Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway.
Liu Y, Mo J, Liang F, Jiang S, Xiong J, Meng X, Mo Z
Frontiers in pharmacology 2023;14:1062664
Frontiers in pharmacology 2023;14:1062664
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Jia M, Zhou KY, Deng LJ, Fang S
American journal of cancer research 2023;13(7):3013-3026
American journal of cancer research 2023;13(7):3013-3026
Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma.
Chen P, Cai X, Mu G, Duan Y, Jing C, Yang Z, Yang C, Wang X
Theranostics 2023;13(7):2140-2153
Theranostics 2023;13(7):2140-2153
CYR61 promotes colorectal carcinoma progression via activating epithelial-mesenchymal transition.
Rasool S, Ismaeel QA, Arif SH
American journal of cancer research 2023;13(10):4872-4887
American journal of cancer research 2023;13(10):4872-4887
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism.
Duan C, Hou L, Deng X, Wu J, Qian W, Han C, Hou X
Frontiers in cellular and infection microbiology 2023;13:1190602
Frontiers in cellular and infection microbiology 2023;13:1190602
Triptolide inhibits the progression of Glioblastoma U251 cells via targeting PROX1.
Yuan C, Liao Y, Liao S, Huang M, Li D, Wu W, Quan Y, Li L, Yu X, Si W
Frontiers in oncology 2023;13:1077640
Frontiers in oncology 2023;13:1077640
A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors.
Ding Q, Li R, Wang Q, Yu L, Zi F
Frontiers in oncology 2023;13:1049147
Frontiers in oncology 2023;13:1049147
EXOSC10 is a novel hepatocellular carcinoma prognostic biomarker: a comprehensive bioinformatics analysis and experiment verification.
Meng ZY, Fan YC, Zhang CS, Zhang LL, Wu T, Nong MY, Wang T, Chen C, Jiang LH
PeerJ 2023;11:e15860
PeerJ 2023;11:e15860
Combined effects of EMP and RF field on emotional behavior in mice.
Qin T, Liu L, Wang X, Guo L, Lin J, Du J, Xue Y, Lai P, Jing Y, Ding G
Frontiers in public health 2023;11:1087161
Frontiers in public health 2023;11:1087161
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.
Jin Z, Liu Y
Heliyon 2023 Sep;9(9):e19816
Heliyon 2023 Sep;9(9):e19816
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Tan C, Shi W, Zhang Y, Liu C, Hu T, Chen D, Huang J
Life science alliance 2023 Sep;6(9)
Life science alliance 2023 Sep;6(9)
Knockdown of NF-κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway.
Xu X, Hou D, Wang Y, Zhang J, Hei Y, Wang B, Tian S, Zhang Y, Wang F
Molecular biology reports 2023 Sep;50(9):7501-7513
Molecular biology reports 2023 Sep;50(9):7501-7513
TGF-β3 Protects Neurons Against Intermittent Hypoxia-Induced Oxidative Stress and Apoptosis Through Activation of the Nrf-2/KEAP1/HO-1 Pathway via Binding to TGF-βRI.
Huang Y, Liu Z, Wang X, Li Y, Liu L, Li B
Neurochemical research 2023 Sep;48(9):2808-2825
Neurochemical research 2023 Sep;48(9):2808-2825
Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng-Nian-Shu in perimenopausal syndrome.
Lv X, Xu Q, Zhang Z, Wang J, Wan M, Zhang X, Wu B, Yan T, Jia Y
Journal of separation science 2023 Sep;46(17):e2300011
Journal of separation science 2023 Sep;46(17):e2300011
Baicalin promotes random-pattern skin flap survival by inducing autophagy via AMPK-regulated TFEB nuclear transcription.
Zhang L, Yu G, Yu Q, Wang L, Wu L, Tao Z, Ding J, Lin D
Phytotherapy research : PTR 2023 Sep;37(9):3926-3938
Phytotherapy research : PTR 2023 Sep;37(9):3926-3938
Apelin-Overexpressing Neural Stem Cells in Conjunction with a Silk Fibroin Nanofiber Scaffold for the Treatment of Traumatic Brain Injury.
Li T, Tang Q, Xu J, Ye X, Chen K, Zhong J, Zhu J, Lu S, Zhu T
Stem cells and development 2023 Sep;32(17-18):539-553
Stem cells and development 2023 Sep;32(17-18):539-553
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway.
Miao J, Chen B, Xiao Y, Huang R, Xiao X, Lu S, Zhang L, Wang X, Ouyang Y, Chen X, Chen Q, Xiang Y, Guo X, Deng X, Wang L, Mai H, Zhao C
Cancer gene therapy 2023 Sep;30(9):1249-1259
Cancer gene therapy 2023 Sep;30(9):1249-1259
Downregulation of ACC expression suppresses cell viability and migration in the malignant progression of breast cancer.
Jin M, Yuan C, Duan S, Zeng B, Pan L
Experimental and therapeutic medicine 2023 Sep;26(3):445
Experimental and therapeutic medicine 2023 Sep;26(3):445
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
Sun T, Liu Z
Pathology, research and practice 2023 Sep;249:154719
Pathology, research and practice 2023 Sep;249:154719
Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.
Cui Y, Zhang W, Yang P, Zhu S, Luo S, Li M
Free radical biology & medicine 2023 Sep;206:33-49
Free radical biology & medicine 2023 Sep;206:33-49
Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats.
Guo S, Chen J, Yang Y, Li X, Tang Y, Gui Y, Chen J, Xu J
Neurospine 2023 Sep;20(3):1011-1027
Neurospine 2023 Sep;20(3):1011-1027
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway.
Meng HW, Shen ZB, Meng XS, Leng-Wei, Yin ZQ, Wang XR, Zou TF, Liu ZG, Wang TX, Zhang S, Chen YL, Yang XX, Li QS, Duan YJ
Bioorganic chemistry 2023 Sep;138:106654
Bioorganic chemistry 2023 Sep;138:106654
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.
Zhang W, Chen H, Xu Z, Zhang X, Tan X, He N, Shen J, Dong J
International immunopharmacology 2023 Sep;122:110563
International immunopharmacology 2023 Sep;122:110563
Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway.
Li Y, Hu S, Chen Y, Zhang X, Gao H, Tian J, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154924
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154924
Loss and recovery of myocardial mitochondria in mice under different tail suspension time: Apoptosis and mitochondrial fission, fusion and autophagy.
Wang Z, Wang XC, Chen YF, Wang CL, Chen L, Jiang MY, Liu XW, Zhang XX, Feng YZ, Xu JH
Experimental physiology 2023 Sep;108(9):1189-1202
Experimental physiology 2023 Sep;108(9):1189-1202
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Wang Z, Zhu D, Zhang Y, Xia F, Zhu J, Dai J, Zhuge X
Microbial cell factories 2023 Sep 9;22(1):177
Microbial cell factories 2023 Sep 9;22(1):177
Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels.
Al-Zahaby SA, Farag MR, Alagawany M, Taha HSA, Varoni MV, Crescenzo G, Mawed SA
Animals : an open access journal from MDPI 2023 Sep 9;13(18)
Animals : an open access journal from MDPI 2023 Sep 9;13(18)
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.
Chen J, Lin Y, Zheng S, Chen Q, Tang S, Zhong X
Journal of translational medicine 2023 Sep 6;21(1):600
Journal of translational medicine 2023 Sep 6;21(1):600
Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia.
Chen YX, Yang H, Wang DS, Yao YT, Chen TT, Tao L, Chen Y, Shen XC
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Biochemical and biophysical research communications 2023 Sep 3;671:246-254
Resveratrol-Coated Gold Nanoflowers for CT Imaging and Apoptosis/Photothermal Synergistic Therapy of Malignant Melanoma.
Yang T, Ren H, Zhang W, Rong L, Zhang D
ACS omega 2023 Sep 26;8(38):34629-34639
ACS omega 2023 Sep 26;8(38):34629-34639
Oryza sativa L. Indica Seed Coat Ameliorated Concanavalin A-Induced Acute Hepatitis in Mice via MDM2/p53 and PKCα/MAPK1 Signaling Pathways.
Zhao Z, Li Y, Guo S, Chen Y, Yin H, Li Y, Cheng G, Tian L
International journal of molecular sciences 2023 Sep 25;24(19)
International journal of molecular sciences 2023 Sep 25;24(19)
Comprehensive Analysis of the Transcriptome-Wide m(6)A Methylome in Shaziling Pig Testicular Development.
Chen C, Tang X, Yan S, Yang A, Xiang J, Deng Y, Yin Y, Chen B, Gu J
International journal of molecular sciences 2023 Sep 23;24(19)
International journal of molecular sciences 2023 Sep 23;24(19)
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
Fang Z, Wang Y, Huang B, Chen X, Jiang R, Yin M
Cell death & disease 2023 Sep 22;14(9):627
Cell death & disease 2023 Sep 22;14(9):627
Progranulin promoted the proliferation, metastasis, and suppressed apoptosis via JAK2-STAT3/4 signaling pathway in papillary thyroid carcinoma.
Dong Y, Tan H, Wang L, Liu Z
Cancer cell international 2023 Sep 2;23(1):191
Cancer cell international 2023 Sep 2;23(1):191
Stereospecificity of Ginsenoside AD-1 and AD-2 Showed Anticancer Activity via Inducing Mitochondrial Dysfunction and Reactive Oxygen Species Mediate Cell Apoptosis.
Wang X, Ding M, Zhao H, Zhou M, Lu X, Sun Y, Zhang Q, Zhao Y, Wang R
Molecules (Basel, Switzerland) 2023 Sep 19;28(18)
Molecules (Basel, Switzerland) 2023 Sep 19;28(18)
CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation.
Luo L, Li T, Zeng Z, Li H, He X, Chen Y
Cell death & disease 2023 Sep 19;14(9):614
Cell death & disease 2023 Sep 19;14(9):614
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
Wang L, Cheng F, Pan R, Cui Z, She J, Zhang Y, Yang X
International journal of molecular sciences 2023 Sep 18;24(18)
International journal of molecular sciences 2023 Sep 18;24(18)
A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy.
Urade R, Chang WT, Ko CC, Li RN, Yang HM, Chen HY, Huang LY, Chang MY, Wu CY, Chiu CC
Life sciences 2023 Sep 15;329:121835
Life sciences 2023 Sep 15;329:121835
Tat-P combined with GAPR1 releases Beclin1 to promote autophagy and improve Bronchopulmonary dysplasia model.
Zhou Y, Zhu Y, Jin W, Yan R, Fang Y, Zhang F, Tang T, Chen S, Chen J, Zhang F, Yu Z, Zang L, Yu Z
iScience 2023 Sep 15;26(9):107509
iScience 2023 Sep 15;26(9):107509
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Zhang B, Chen ZY, Jiang Z, Huang S, Liu XH, Wang L
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
POFUT1 promotes gastric cancer progression through Notch/Wnt dual signaling pathways dependent on the parafibromin-NICD1-β-catenin complex.
Dong S, Wang Z, Xiong W
Journal of the Chinese Medical Association : JCMA 2023 Sep 1;86(9):806-817
Journal of the Chinese Medical Association : JCMA 2023 Sep 1;86(9):806-817
Long-term iTBS Improves Neural Functional Recovery by Reducing the Inflammatory Response and Inhibiting Neuronal Apoptosis Via miR-34c-5p/p53/Bax Signaling Pathway in Cerebral Ischemic Rats.
Hu S, Wang X, Yang X, Ouyang S, Pan X, Fu Y, Wu S
Neuroscience 2023 Sep 1;527:37-51
Neuroscience 2023 Sep 1;527:37-51
Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.
Li Z, Jin T, Yang R, Guo J, Niu Z, Gao H, Song X, Zhang Q, Ning Z, Ren L, Wang Y, Fan X, Liang H, Li T, He W
Experimental cell research 2023 Sep 1;430(1):113685
Experimental cell research 2023 Sep 1;430(1):113685
Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway.
Liu Z, Wang X, Li J, Yang X, Huang J, Ji C, Li X, Li L, Zhou J, Hu Y
Chemico-biological interactions 2023 Sep 1;382:110602
Chemico-biological interactions 2023 Sep 1;382:110602
Identification and evaluation of a novel PARP1 inhibitor for the treatment of triple-negative breast cancer.
Gong R, Ma Z, He L, Jiang S, Cao D, Cheng Y
Chemico-biological interactions 2023 Sep 1;382:110567
Chemico-biological interactions 2023 Sep 1;382:110567
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Yang Z, Wu S, He S, Han L, Zhou M, Yang J, Chen J, Wu G
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
Honokiol alleviates radiation-induced premature ovarian failure via enhancing Nrf2.
Xin L, Li F, Yu H, Xiong Q, Hou Q, Meng Y
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13769
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13769
Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis.
Feng R, Liu J, Yang Z, Yao T, Ye P, Li X, Zhang J, Jiang H
Molecular neurobiology 2023 Oct;60(10):6001-6017
Molecular neurobiology 2023 Oct;60(10):6001-6017
The role of HIF-1α-mediated autophagy in ionizing radiation-induced testicular injury.
Xu R, Shen S, Wang D, Ye J, Song S, Wang Z, Yue Z
Journal of molecular histology 2023 Oct;54(5):439-451
Journal of molecular histology 2023 Oct;54(5):439-451
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis.
Xiao Y, Yu Y, Hu L, Yang Y, Yuan Y, Zhang W, Luo J, Yu L
Inflammation 2023 Oct;46(5):1684-1696
Inflammation 2023 Oct;46(5):1684-1696
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
Liu Y, Yan Z, Ren Y, Wang W, Ke Y, Wang Y, Qi R
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Oct;41(5):284-296
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Oct;41(5):284-296
The role of NADPH oxidase 1 in alcohol-induced oxidative stress injury of intestinal epithelial cells.
Chen L, Chu H, Hu L, Li Z, Yang L, Hou X
Cell biology and toxicology 2023 Oct;39(5):2345-2364
Cell biology and toxicology 2023 Oct;39(5):2345-2364
miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a.
Hou D, Pei C, Yu D, Yang G
Metabolic brain disease 2023 Oct;38(7):2327-2338
Metabolic brain disease 2023 Oct;38(7):2327-2338
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
Zhao B, Qiao H, Zhao Y, Gao Z, Wang W, Cui Y, Li J, Guo Z, Chuai X, Chiu S
Virologica Sinica 2023 Oct;38(5):680-689
Virologica Sinica 2023 Oct;38(5):680-689
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Tian Y, Ma J, Wang M, Yi X, Guo S, Wang H, Zhang H, Wang H, Yang Y, Zhang B, Du J, Shi Q, Gao T, Li C, Guo W
Experimental dermatology 2023 Oct;32(10):1633-1643
Experimental dermatology 2023 Oct;32(10):1633-1643
The effect of small molecule inhibitor NSC348884 on nucleophosmin 1-mutated acute myeloid leukemia cells.
Zhu JF, Han LL, Ma Y, Wang YX, Zhang F
European review for medical and pharmacological sciences 2023 Oct;27(19):9145-9151
European review for medical and pharmacological sciences 2023 Oct;27(19):9145-9151
Effect of doramectin on programmed cell death pathway in glioma cells.
Du S, Liang H, Zhou L, Chen C, Sun R, Zhang J, Meng X, Gao A
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 Oct;25(10):2871-2883
Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms.
Carter JL, Su Y, Qiao X, Zhao J, Wang G, Howard M, Edwards H, Bao X, Li J, Hüttemann M, Yang J, Taub JW, Ge Y
Biochemical pharmacology 2023 Oct;216:115759
Biochemical pharmacology 2023 Oct;216:115759
Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder.
Xiong F, Jiang K, Wu Y, Lou C, Ding C, Zhang W, Zhang X, Li C, Zheng H, Gao H
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166725
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166725
Myeloid-specific deletion of Capns1 attenuates myocardial infarction injury via restoring mitochondrial function and inhibiting inflammasome activation.
Xiao Z, Wei X, Li M, Yang K, Chen R, Su Y, Yu Z, Liang Y, Ge J
Journal of molecular and cellular cardiology 2023 Oct;183:54-66
Journal of molecular and cellular cardiology 2023 Oct;183:54-66
Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway.
Pan M, Wang Z, Wang Y, Jiang X, Fan Y, Gong F, Sun Y, Wang D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115333
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.
Yin Z, You S, Zhang S, Zhang L, Wu B, Huang X, Lu S, Cao L, Zhang Y, Li D, Zhang X, Liu J, Sun Y, Zhang N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115228
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115228
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Zhang M, Zhu LZ, Yang CJ, Yan JX, Wang ZP, Bai YP, Peng LZ, Luo HB, Zhang ZJ, Li L, Xu CR, Liu YQ
Bioorganic chemistry 2023 Oct;139:106652
Bioorganic chemistry 2023 Oct;139:106652
Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM(2.5) exposure by downregulating the PGC-1α/SIRT3 signaling pathway.
Huang L, Xu J, Duan K, Bao T, Cheng Y, Zhang H, Zhang Y, Lin Y, Li F
Toxicology research 2023 Oct;12(5):756-764
Toxicology research 2023 Oct;12(5):756-764
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Li C, Han S, Zhu J, Cheng F
Cellular signalling 2023 Oct;110:110801
Cellular signalling 2023 Oct;110:110801
Retinal Microenvironment-Protected Rhein-GFFYE Nanofibers Attenuate Retinal Ischemia-Reperfusion Injury via Inhibiting Oxidative Stress and Regulating Microglial/Macrophage M1/M2 Polarization.
Zhang Z, Peng S, Xu T, Liu J, Zhao L, Xu H, Zhang W, Zhu Y, Yang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2302909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2302909
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity.
Chen X, Liu C, Zhao H, Zhong Y, Xu Y, Wang Y
Biology direct 2023 Oct 9;18(1):63
Biology direct 2023 Oct 9;18(1):63
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway.
Chen J, Lin X, Liu K, He J, Li X, Zhang C, Deng Y, Luo L, Tao C, Wang Q
European journal of pharmacology 2023 Oct 5;956:175871
European journal of pharmacology 2023 Oct 5;956:175871
Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer.
Zhou A, Zhou C, Wang D, Qian M, Huang L
Journal of ethnopharmacology 2023 Oct 5;314:116576
Journal of ethnopharmacology 2023 Oct 5;314:116576
A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo.
Xue Z, Zhou M, Liu Y, Qin H, Li Y, Zhu Y, Yang J
Journal of ethnopharmacology 2023 Oct 5;314:116544
Journal of ethnopharmacology 2023 Oct 5;314:116544
Moschus ameliorates glutamate-induced cellular damage by regulating autophagy and apoptosis pathway.
Xie D, Song C, Qin T, Zhai Z, Cai J, Dai J, Sun T, Xu Y
Scientific reports 2023 Oct 30;13(1):18586
Scientific reports 2023 Oct 30;13(1):18586
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration.
Ren X, Zhuang H, Zhang Y, Zhou P
Journal of nanobiotechnology 2023 Oct 3;21(1):359
Journal of nanobiotechnology 2023 Oct 3;21(1):359
Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway.
Li H, Zhang C, Zhou Y, Deng Y, Zheng X, Xue X
Aging 2023 Oct 26;15(20):11639-11653
Aging 2023 Oct 26;15(20):11639-11653
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
BMP7 alleviates trigeminal neuralgia by reducing oligodendrocyte apoptosis and demyelination.
Chen K, Wei X, Wang R, Yang L, Zou D, Wang Y
The journal of headache and pain 2023 Oct 24;24(1):143
The journal of headache and pain 2023 Oct 24;24(1):143
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Li X, Liu Z, He Z, Wang X, Li R, Wang J, Ma G, Zhang P, Ma C
BMC endocrine disorders 2023 Oct 23;23(1):230
BMC endocrine disorders 2023 Oct 23;23(1):230
Development of novel cytoprotective small compounds inhibiting mitochondria-dependent cell death.
Matsuyama M, Ortega JT, Fedorov Y, Scott-McKean J, Muller-Greven J, Buck M, Adams D, Jastrzebska B, Greenlee W, Matsuyama S
iScience 2023 Oct 20;26(10):107916
iScience 2023 Oct 20;26(10):107916
Focused low-intensity pulsed ultrasound alleviates osteoarthritis via restoring impaired FUNDC1-mediated mitophagy.
Ye H, Li D, Wei X, Yu L, Jia L
iScience 2023 Oct 20;26(10):107772
iScience 2023 Oct 20;26(10):107772
The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Cai Y, Sun H, Song X, Zhao J, Xu D, Liu M
Aging 2023 Oct 19;15(20):11471-11488
Aging 2023 Oct 19;15(20):11471-11488
Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells.
Zhang X, Zhang D, Li H, Liu Z, Yang Y, Li J, Tang L, Tao J, Liu H, Shen M
Antioxidants (Basel, Switzerland) 2023 Oct 19;12(10)
Antioxidants (Basel, Switzerland) 2023 Oct 19;12(10)
[Mechanism of nuclear protein 1 in the resistance to axitinib in clear cell renal cell carcinoma].
Liu YC, Wu ZL, Ge LY, DU T, Wu YQ, Song YM, Liu C, Ma LL
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2023 Oct 18;55(5):781-792
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2023 Oct 18;55(5):781-792
Mutation of the ETS1 3'UTR interacts with miR-216a-3p to regulate granulosa cell apoptosis in sheep.
Yang F, Liu Y, Wang P, Wang X, Chu M, Wang P
Theriogenology 2023 Oct 15;210:133-142
Theriogenology 2023 Oct 15;210:133-142
The effects of protein-rich extract from Rhizoma Gastrodiae against cerebral ischemia/reperfusion injury via regulating MAPK and PI3K/AKT signaling pathway.
Duan X, Song N, Ma K, Tong Y, Yang L
Brain research bulletin 2023 Oct 15;203:110772
Brain research bulletin 2023 Oct 15;203:110772
The Yeast and Hypha Phases of Candida krusei Induce the Apoptosis of Bovine Mammary Epithelial Cells via Distinct Signaling Pathways.
Miao Y, Ding T, Liu Y, Zhou X, Du J
Animals : an open access journal from MDPI 2023 Oct 15;13(20)
Animals : an open access journal from MDPI 2023 Oct 15;13(20)
Dendrobium officinale polysaccharide Converts M2 into M1 Subtype Macrophage Polarization via the STAT6/PPAR-r and JAGGED1/NOTCH1 Signaling Pathways to Inhibit Gastric Cancer.
Zhao Y, Lu X, Huang H, Yao Y, Liu H, Sun Y
Molecules (Basel, Switzerland) 2023 Oct 12;28(20)
Molecules (Basel, Switzerland) 2023 Oct 12;28(20)
METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
Yi J, Peng F, Zhao J, Gong X
Scientific reports 2023 Oct 12;13(1):17292
Scientific reports 2023 Oct 12;13(1):17292
Peptide Characterization of Bovine Myocardium Hydrolysates and Its Ameliorative Effects on Doxorubicin-Induced Myocardial Injury in H9c2 Cells and in Mice.
Li W, Lv M, Zhang T, Zhou M, Zheng L, Song T, Zhao M
Journal of agricultural and food chemistry 2023 Oct 11;71(40):14562-14574
Journal of agricultural and food chemistry 2023 Oct 11;71(40):14562-14574
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Ke W, Wang B, Liao Z, Song Y, Li G, Ma L, Wang K, Li S, Hua W, Yang C
Journal of translational medicine 2023 Oct 10;21(1):711
Journal of translational medicine 2023 Oct 10;21(1):711
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Wang H, He D, Li Z, Gao X, Yang S, Cui M, Ye B, Huang B, Fu S, Liu D
Chemico-biological interactions 2023 Oct 1;384:110726
Chemico-biological interactions 2023 Oct 1;384:110726
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Liu Z, Huang J, Wang X, Deng S, Zhou J, Gong Z, Li X, Wang Y, Yang J, Hu Y
Chemico-biological interactions 2023 Oct 1;384:110724
Chemico-biological interactions 2023 Oct 1;384:110724
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.
Zhang T, Bai J, Chen G, Chen Z, Zeng S, Yang Y, Wu Z
Chemico-biological interactions 2023 Oct 1;384:110695
Chemico-biological interactions 2023 Oct 1;384:110695
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis.
Ma R, Sun T, Wang X, Ren K, Min T, Xie X, Wang D, Li K, Zhang Y, Zhu K, Mo C, Dang C, Yang Y, Zhang H
Ecotoxicology and environmental safety 2023 Oct 1;264:115475
Ecotoxicology and environmental safety 2023 Oct 1;264:115475
FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Zhang W, Lin W, Zeng X, Zhang M, Chen Q, Tang Y, Sun J, Liang B, Zha L, Yu Z
Aging and disease 2023 Oct 1;14(5):1927-1944
Aging and disease 2023 Oct 1;14(5):1927-1944
Dendrobium mixture ameliorates hepatic injury induced by insulin resistance in vitro and in vivo through the downregulation of AGE/RAGE/Akt signaling pathway.
Zhuang S, Zhou X, Yang X, Chang D, Chen T, Sun Y, Wang C, Zhang C, Jiang J, Chen Y, Lin X, Wang X, Yu W, Lin X, He C, Zheng Y, Zhang J, Shi H
Heliyon 2023 Nov;9(11):e22007
Heliyon 2023 Nov;9(11):e22007
Rutaecarpine Mitigates Cognitive Impairment by Balancing Mitochondrial Function Through Activation of the AMPK/PGC1α Pathway.
Gong M, Jia J
Molecular neurobiology 2023 Nov;60(11):6598-6612
Molecular neurobiology 2023 Nov;60(11):6598-6612
Suppression of the gut microbiota-bile acid-FGF19 axis in patients with atrial fibrillation.
Zuo K, Fang C, Gao Y, Fu Y, Wang H, Li J, Zhong J, Yang X, Xu L
Cell proliferation 2023 Nov;56(11):e13488
Cell proliferation 2023 Nov;56(11):e13488
The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice.
Li ZF, Feng JK, Zhao XC, Liu W, Gu SA, Li R, Lu YL, Mao RJ, Xia LL, Dong LL, Zhang LW, Ruan JY, Liu J, Li GF, Li T, Sun R, Qiu SL, Zheng ZZ, Dong T
Transplantation proceedings 2023 Nov;55(9):2232-2240
Transplantation proceedings 2023 Nov;55(9):2232-2240
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer.
Yang K, Wang JQ, Li K, Chen SN, Yu F
Oncology reports 2023 Nov;50(5)
Oncology reports 2023 Nov;50(5)
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.
Hu H, Wang Y, Dong Y, Wang L, Chen Y, Zhou Y, Sun L
Molecular biology reports 2023 Nov;50(11):8985-8993
Molecular biology reports 2023 Nov;50(11):8985-8993
Decrease of Cellular Communication Network Factor 1 (CCN1) Attenuates PTZ-Kindled Epilepsy in Mice.
Liao Y, Huang S, Zhang Y, Zhang H, Zhao H
Cellular and molecular neurobiology 2023 Nov;43(8):4279-4293
Cellular and molecular neurobiology 2023 Nov;43(8):4279-4293
Polydatin inhibited TNF-α-induced apoptosis of skeletal muscle cells through AKT-mediated p38 MAPK and NF-κB pathways.
Liu Y, Xie F, Lu C, Zhou Z, Li S, Zhong J, Li Q, Shao X
General physiology and biophysics 2023 Nov;42(6):521-529
General physiology and biophysics 2023 Nov;42(6):521-529
Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.
Zhang J, Yuan H, Li W, Chen S, Liu S, Li C, Yao X
Mycotoxin research 2023 Nov;39(4):347-364
Mycotoxin research 2023 Nov;39(4):347-364
Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix.
Liu R, Liu Z, Chen H, He S, Wang S, Dai J, Li X
Phytotherapy research : PTR 2023 Nov;37(11):5205-5222
Phytotherapy research : PTR 2023 Nov;37(11):5205-5222
Phenothiazines reduced autophagy in ischemic stroke through endoplasmic reticulum (ER) stress-associated PERK-eIF2α pathway.
Lv S, Geng X, Yun HJ, Ding Y
Experimental neurology 2023 Nov;369:114524
Experimental neurology 2023 Nov;369:114524
Plasma metabonomic study on the effect of Para‑hydroxybenzaldehyde intervention in a rat model of transient focal cerebral ischemia.
Yu X, Luo Y, Yang L, Duan X
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF-κB pathway in grass carp.
Li S, Xie J, Li K, Bai Y, Jiang Z, Xiong X
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109734
An HPK1 inhibitor enhanced the tumour response to anti-PD-1 immunotherapy in non-Hodgkin's lymphoma.
Yang L, Zhao Q, Chen T, Liu W, Qiu X, Chen J, Huang S, Huang R, Dong L
Clinical and experimental medicine 2023 Nov;23(7):3767-3780
Clinical and experimental medicine 2023 Nov;23(7):3767-3780
Glutathione Might Attenuate Arsenic-Induced Liver Injury by Modulating the Foxa2-XIAP Axis to Reduce Oxidative Stress and Mitochondrial Apoptosis.
Zhang H, Jin B, Liu L, Li H, Zheng X, Li M, He R, Wang K
Biological trace element research 2023 Nov;201(11):5201-5212
Biological trace element research 2023 Nov;201(11):5201-5212
A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.
Zhou X, Zhou A, Tian Z, Chen W, Xu Y, Ning X, Chen K
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(45):e2302952
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(45):e2302952
The novel lncRNA-9802/miR-1646 axis affects cell proliferation of DF-1 by regulating Bax/Bcl-2 signaling pathway.
Han S, Zhao S, Zhao Y, Liu M, Han L, Han L
Research in veterinary science 2023 Nov;164:105047
Research in veterinary science 2023 Nov;164:105047
The role of the Gas6/TAM signal pathway in the LPS-induced pulmonary epithelial cells injury.
Cheng Y, Yang X, Wang Y, Ding Q, Huang Y, Zhang C
Molecular immunology 2023 Nov;163:181-187
Molecular immunology 2023 Nov;163:181-187
The eNOS-induced leonurine's new role in improving the survival of random skin flap.
Chen T, Chen H, Fu Y, Liu X, Huang H, Li Z, Li S
International immunopharmacology 2023 Nov;124(Pt B):111037
International immunopharmacology 2023 Nov;124(Pt B):111037
Trans-anethole pretreatment ameliorates hepatic ischemia-reperfusion injury via regulation of soluble epoxide hydrolase.
Lu J, Hou W, Yang S, Chen D, Wang F, Liu L, Shen Z
International immunopharmacology 2023 Nov;124(Pt A):110809
International immunopharmacology 2023 Nov;124(Pt A):110809
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
Wang Y, Fu M, Xiao W, Zhao Y, Yuan P, Zhang X, Wu W
Advanced healthcare materials 2023 Nov;12(29):e2301247
Advanced healthcare materials 2023 Nov;12(29):e2301247
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.
Ran L, Mou X, Peng Z, Li X, Li M, Xu D, Yang Z, Sun X, Yin T
Scientific reports 2023 Nov 9;13(1):19477
Scientific reports 2023 Nov 9;13(1):19477
Cholestanol accelerates α-synuclein aggregation and spreading by activating asparagine endopeptidase.
Yu T, Nie S, Bu L, Liu M, He J, Niu X, Feng H, Guo J, Tang B, Zhang Z, Ye K, Jiang H, Chen L, Zhang Z
JCI insight 2023 Nov 8;8(21)
JCI insight 2023 Nov 8;8(21)
Activation of the p53 signaling pathway by piRNA-MW557525 overexpression induces a G0/G1 phase arrest thus inhibiting neuroblastoma growth.
Mi T, Tan X, Wang Z, Zhang Z, Jin L, Wang J, Li M, Wu X, He D
European journal of medical research 2023 Nov 8;28(1):503
European journal of medical research 2023 Nov 8;28(1):503
Endoplasmic Reticulum-Targeted Aggregation-Induced Emission Luminogen for Synergetic Tumor Ablation with Glibenclamide.
Wu Y, Chen X, Zhu L, Wang D, Li X, Song J, Wang D, Yu X, Li Y, Tang BZ
ACS applied materials & interfaces 2023 Nov 8;15(44):50821-50835
ACS applied materials & interfaces 2023 Nov 8;15(44):50821-50835
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis.
Yin YJ, Zhang YH, Wang Y, Jiang H, Zhang JB, Liang S, Yuan B
Aging 2023 Nov 8;15(21):12497-12512
Aging 2023 Nov 8;15(21):12497-12512
Shenmai injection ameliorates doxorubicin-induced myocardial injury by suppressing autophagy-apoptosis via miR-30a.
Li Y, Fan L, Wang X, Lv S
Aging 2023 Nov 7;15(21):12400-12412
Aging 2023 Nov 7;15(21):12400-12412
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer.
Xu C, Zhu M, Wang Q, Cui J, Huang Y, Huang X, Huang J, Gai J, Li G, Qiao P, Zeng X, Ju D, Wan Y, Zhang X
Journal of nanobiotechnology 2023 Nov 6;21(1):410
Journal of nanobiotechnology 2023 Nov 6;21(1):410
MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer.
Wang C, Lin H, Zhao W, Liang Y, Chen Y, Wang C
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 30;69(12):232-241
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 30;69(12):232-241
Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication.
Cao X, Li Q, Li X, Liu Q, Liu K, Deng T, Weng X, Yu Q, Deng W, Yu J, Wang Q, Xiao G, Xu X
AAPS PharmSciTech 2023 Nov 28;24(8):241
AAPS PharmSciTech 2023 Nov 28;24(8):241
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration.
Sun Y, Sun Y, Chen S, Yu Y, Ma Y, Sun F
Journal of nanobiotechnology 2023 Nov 25;21(1):449
Journal of nanobiotechnology 2023 Nov 25;21(1):449
DJ1 Ameliorates AD-like Pathology in the Hippocampus of APP/PS1 Mice.
Peng YY, Li MX, Li WJ, Xue Y, Miao YF, Wang YL, Fan XC, Tang LL, Song HL, Zhang Q, Li X
Biomedical and environmental sciences : BES 2023 Nov 20;36(11):1028-1044
Biomedical and environmental sciences : BES 2023 Nov 20;36(11):1028-1044
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Cheng H, Sun Y, Yu X, Zhou D, Ding J, Wang S, Ma F
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury.
Guo M, Shen D, Su Y, Xu J, Zhao S, Zhang W, Wang Y, Jiang W, Wang J, Geng X, Ding X, Xu X
iScience 2023 Nov 17;26(11):108211
iScience 2023 Nov 17;26(11):108211
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
Cai T, Chen S, Wu C, Lou C, Wang W, Lin C, Jiang H, Xu X
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice.
Yu J, Zhao B, Pi Q, Zhou G, Cheng Z, Qu C, Wang X, Kong L, Luo S, Du D, Guo Y
Respiratory research 2023 Nov 17;24(1):288
Respiratory research 2023 Nov 17;24(1):288
The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.
Li Y, Cao H, Qiu D, Wang N, Wang Y, Wen T, Wang J, Zhu H
Cancer cell international 2023 Nov 16;23(1):272
Cancer cell international 2023 Nov 16;23(1):272
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
Methylcrotonyl-CoA carboxylase subunit 1 (MCCA) regulates multidrug resistance in multiple myeloma.
Feng Y, Huang J, Wang F, Lin Z, Luo H, Li Q, Wang X, Liu X, Zhai X, Gao Q, Li L, Zhang Y, Wen J, Zhang L, Niu T, Zheng Y
Life sciences 2023 Nov 15;333:122157
Life sciences 2023 Nov 15;333:122157
Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells.
Luo H, Yang Y, Zhang H, Ren L, Han X, Lin Y, Wu M, Hou Y
Ecotoxicology and environmental safety 2023 Nov 15;267:115652
Ecotoxicology and environmental safety 2023 Nov 15;267:115652
Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines.
K C PB, Maharjan A, Acharya M, Lee D, Kusma S, Gautam R, Kwon JT, Kim C, Kim K, Kim H, Heo Y
The Science of the total environment 2023 Nov 1;897:165295
The Science of the total environment 2023 Nov 1;897:165295
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y
Cancer letters 2023 Nov 1;576:216420
Cancer letters 2023 Nov 1;576:216420
The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer.
Yin Y, Guan X, Li G, Chen C, Duan Y, Yu Z
Toxicology and applied pharmacology 2023 Nov 1;478:116698
Toxicology and applied pharmacology 2023 Nov 1;478:116698
Agrocybe cylindracea fucoglucogalactan induced lysosome-mediated apoptosis of colorectal cancer cell through H3K27ac-regulated cathepsin D.
Wang Z, Chen K, Zhang K, He K, Zhang D, Guo X, Huang T, Hu J, Zhou X, Nie S
Carbohydrate polymers 2023 Nov 1;319:121208
Carbohydrate polymers 2023 Nov 1;319:121208
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
Li Y, Zhong G, He T, Quan J, Liu S, Liu Z, Tang Z, Yu W
Ecotoxicology and environmental safety 2023 Nov 1;266:115542
Ecotoxicology and environmental safety 2023 Nov 1;266:115542
Tumor necrosis factor-α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways.
Yang Z, Zhang F, Abdul M, Jiang J, Li Y, Li Y, Yin C, Xing Y, Liu S, Lu C
Neuropharmacology 2023 Nov 1;238:109667
Neuropharmacology 2023 Nov 1;238:109667
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Zhu Z, Li X, Wang X, Zuo X, Ma Y, Gao X, Liang Z, Zhang Z, Song Z, Ding T, Ju C, Li P, Li K, Zhang J, Quan H, Wang Z, Hu X
Bioengineering & translational medicine 2023 May;8(3):e10473
Bioengineering & translational medicine 2023 May;8(3):e10473
Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity.
Gu T, Xu C, Meng X, Gao D, Jiang G, Yin A, Liu Q, Zhang L
Journal of molecular neuroscience : MN 2023 May;73(4-5):225-236
Journal of molecular neuroscience : MN 2023 May;73(4-5):225-236
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
Wang DY, Zhang J, Li HX, Zhang YX, Jing MR, Cai CB, Wang D, Qi HW, Wang YZ, Chen HJ, Li T, Zhai YK, Ji XY, Wu DD
Molecular carcinogenesis 2023 May;62(5):652-664
Molecular carcinogenesis 2023 May;62(5):652-664
TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro.
Peng X, Guo H, Zhang X, Yang Z, Ruganzu JB, Yang Z, Wu X, Bi W, Ji S, Yang W
Molecular neurobiology 2023 May;60(5):2470-2485
Molecular neurobiology 2023 May;60(5):2470-2485
Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling.
Chen B, Wu J, Hu S, Liu Q, Yang H, You Y
Neurochemical research 2023 May;48(5):1504-1515
Neurochemical research 2023 May;48(5):1504-1515
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Zhang HF, Liu HM, Xiang JY, Zhou XC, Wang D, Chen RY, Tan WL, Liang LQ, Liu LL, Shi MJ, Zhang F, Xiao Y, Zhou YX, Zhang T, Tang L, Guo B, Wang YY
Acta pharmacologica Sinica 2023 May;44(5):1051-1065
Acta pharmacologica Sinica 2023 May;44(5):1051-1065
The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target.
Xu Y, Hirachan S, Shen Y, Huang Q, Bhandari A, Xia E
Environmental toxicology 2023 May;38(5):1100-1117
Environmental toxicology 2023 May;38(5):1100-1117
Shenlian extract decreases mitochondrial autophagy to regulate mitochondrial function in microvascular to alleviate coronary artery no-reflow.
Li JJ, Wang YJ, Wang CM, Li YJ, Yang Q, Cai WY, Chen Y, Zhu XX
Phytotherapy research : PTR 2023 May;37(5):1864-1882
Phytotherapy research : PTR 2023 May;37(5):1864-1882
TRPM8 promotes hepatocellular carcinoma progression by inducing SNORA55 mediated nuclear-mitochondrial communication.
Fu J, Liu G, Zhang X, Lei X, Liu Q, Qian K, Tong Q, Qin W, Li Z, Cao Z, Zhang J, Liu C, Wang Z, Liu Z, Liang XM, Yamamoto H, Xu X
Cancer gene therapy 2023 May;30(5):738-751
Cancer gene therapy 2023 May;30(5):738-751
miR-27a-3p relieves heat stress-induced mitochondrial damage and aberrant milk protein synthesis through MEK/ERK pathway in BMECs.
Wang Y, Wu J, Xia SW, Zhao F, Ding Q, Ye XM, Zhong JF, Chen KL, Wang HL
Cell stress & chaperones 2023 May;28(3):265-274
Cell stress & chaperones 2023 May;28(3):265-274
Experimental study of the effects of absorbable gelatin sponge and non‑absorbable polyvinyl alcohol particle material used in transcatheter arterial embolization on liver tissues.
Liu J, Wang S, Xue X, Hu T, Peng X, Huang J, Zhou S
Experimental and therapeutic medicine 2023 May;25(5):229
Experimental and therapeutic medicine 2023 May;25(5):229
Inhibitory effect and mechanism of hirsuteine on NCI‑H1299 lung cancer cell lines.
Yun X, Qin H, Du B, Peng Y, Liu Y, Yang B
Oncology letters 2023 May;25(5):202
Oncology letters 2023 May;25(5):202
Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization.
Yu Y, Xia LK, Di Y, Nie QZ, Chen XL
Neural regeneration research 2023 May;18(5):1132-1138
Neural regeneration research 2023 May;18(5):1132-1138
Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1.
Zhuang H, Ren X, Zhang Y, Jiang F, Zhou P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113726
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113726
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
Yang C, Wang ZQ, Zhang ZC, Lou G, Jin WL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway.
Wang X, Jia J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114473
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114473
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
Dong Y, Han F, Su Y, Sun B, Zhao W, Pan C
International immunopharmacology 2023 May;118:110056
International immunopharmacology 2023 May;118:110056
C1q/tumor necrosis factor-related protein-9 exerts antioxidant and anti-inflammatory effects on oxygen-glucose deprivation/reoxygenation-stimulated neurons by modulating the Akt-GSK-3β-Nrf2 cascade via AdipoR1.
Wang J, Ren B, Yang Y, Li Y
International immunopharmacology 2023 May;118:110045
International immunopharmacology 2023 May;118:110045
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627
World journal of gastroenterology 2023 May 7;29(17):2616-2627
Inhibition of AGEs-RAGE-PP2A Axis Alleviates Cognitive Impairment after Chronic Heart Failure.
Li S, Wang L, Wang J, Liang B, Gao W, Huang Y, Deng B, Liu Q, Zhou Z, Zhang L, Xian S, Wang L, Liu J, Wang Z
Cellular and molecular biology (Noisy-le-Grand, France) 2023 May 31;69(5):179-185
Cellular and molecular biology (Noisy-le-Grand, France) 2023 May 31;69(5):179-185
Porphin e6 complex loaded with gold nanorod mesoporous silica enhances photodynamic therapy in ovarian cancer cells in vitro.
Sun Q, Suo Y, Lv H, Wang Q, Yin H
Lasers in medical science 2023 May 3;38(1):115
Lasers in medical science 2023 May 3;38(1):115
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma.
Luo M, Huang M, Yang N, Zhu Y, Huang P, Xu Z, Wang W, Cai L
Bone research 2023 May 29;11(1):28
Bone research 2023 May 29;11(1):28
A Novel Mitovirus PsMV2 Facilitates the Virulence of Wheat Stripe Rust Fungus.
Zhang Y, Guo H, Zhou S, Chen D, Xu G, Kang Z, Zheng L
Viruses 2023 May 28;15(6)
Viruses 2023 May 28;15(6)
Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.
Liu DN, Liu M, Zhang SS, Shang YF, Zhang WF, Song FH, Zhang HW, Du GH, Wang YH
Marine drugs 2023 May 27;21(6)
Marine drugs 2023 May 27;21(6)
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Li W, Tao C, Mao M, Zhu K
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer.
Li X, Jiang S, Jiang T, Sun X, Guan Y, Fan S, Cheng Y
Cancers 2023 May 26;15(11)
Cancers 2023 May 26;15(11)
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Zhang X, Wang S, Jin Y, Wang J, Wang R, Yang X, Zhang S, Yan T, Jia Y
Journal of ethnopharmacology 2023 May 23;308:116253
Journal of ethnopharmacology 2023 May 23;308:116253
The therapeutic mechanism of Yuye decoction on type 2 diabetes mellitus based on network pharmacology and experimental verification.
Guo F, Yao L, Zhang W, Chen P, Hao R, Huang X, Jiang J, Wu S
Journal of ethnopharmacology 2023 May 23;308:116222
Journal of ethnopharmacology 2023 May 23;308:116222
Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.
Zhang ZH, Zhou XM, Zhang X
Brain sciences 2023 May 18;13(5)
Brain sciences 2023 May 18;13(5)
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Zhang Z, Guo L, Yang F, Peng S, Wang D, Lai X, Su B, Xie H
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Zhang Q, Ye J, Zhang Z, Hu Y, Wang X, Jiang W, Guo X, Chen L, Cheng S, Li J, Zhang L
Toxicology letters 2023 May 15;381:27-35
Toxicology letters 2023 May 15;381:27-35
Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives.
Wang C, Zhu M, Long X, Wang Q, Wang Z, Ouyang G
International journal of molecular sciences 2023 May 12;24(10)
International journal of molecular sciences 2023 May 12;24(10)
20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis.
Zhang Q, Yang X, Liu J, Song J, Zhang S, Chen L, Zhang M
Food & function 2023 May 11;14(9):4191-4203
Food & function 2023 May 11;14(9):4191-4203
Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway.
Chen F, Cui JJ, Jiang DC, Wang HZ, Zhuang W, Feng YN, Lin XL, Xi SY
Journal of ethnopharmacology 2023 May 10;307:116252
Journal of ethnopharmacology 2023 May 10;307:116252
The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts.
Xi T, Wang R, Pi D, Ouyang J, Yang J
Experimental cell research 2023 May 1;426(1):113556
Experimental cell research 2023 May 1;426(1):113556
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via modulating the PKCα/Cx43 signaling pathway.
Wang Q, Ma Y, Li Y, He Z, Feng B
Chemico-biological interactions 2023 May 1;376:110451
Chemico-biological interactions 2023 May 1;376:110451
MicroRNA-22-3p Regulates the Apoptosis of Lens Epithelial Cells Through Targeting KLF6 in Diabetic Cataracts.
Yin X, Chen L, Shen J, Bi Z, Chen C, Zhao X, Liu S, Li Y
Translational vision science & technology 2023 May 1;12(5):9
Translational vision science & technology 2023 May 1;12(5):9
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Wang G, Shen X, Song X, Wang N, Wo X, Gao Y
Neurotoxicology 2023 Mar;95:12-22
Neurotoxicology 2023 Mar;95:12-22
Electroacupuncture alleviates early brain injury via modulating microglia polarization and suppressing neuroinflammation in a rat model of subarachnoid hemorrhage.
Wang Y, Yang X, Cao Y, Li X, Xu R, Yan J, Guo Z, Sun S, Sun X, Wu Y
Heliyon 2023 Mar;9(3):e14475
Heliyon 2023 Mar;9(3):e14475
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Liu X, Liu Y, Chen L, Zhang Z, Cui L, Wei T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Study on the effect of 5-aminolevulinic acid-mediated photodynamic therapy combined with cisplatin on human ovarian cancer OVCAR-3 cells.
Lv H, Suo Y, Sun Q, Fan J, Wang Q
Advances in medical sciences 2023 Mar;68(1):147-156
Advances in medical sciences 2023 Mar;68(1):147-156
Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway.
Zhang L, Zhou T, Ji Q, He L, Lan Y, Ding L, Li L, Wang Z
Molecular biology reports 2023 Mar;50(3):2545-2557
Molecular biology reports 2023 Mar;50(3):2545-2557
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
Fu J, Yu L, Yu Q, Yu N, Xu F, Li S
Journal of ginseng research 2023 Mar;47(2):274-282
Journal of ginseng research 2023 Mar;47(2):274-282
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells.
Qu Y, Zong S, Wang Z, Du P, Wen Y, Li H, Wu N, Xiao H
Drug and chemical toxicology 2023 Mar;46(2):369-379
Drug and chemical toxicology 2023 Mar;46(2):369-379
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects.
He X, Guo X, Deng B, Kang J, Liu W, Zhang G, Wang Y, Yang Y, Kang X
Experimental neurology 2023 Mar;361:114301
Experimental neurology 2023 Mar;361:114301
Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p.
Wang R, Zhao J, Liu C, Li S, Liu W, Cao Q
Reproductive biology 2023 Mar;23(1):100735
Reproductive biology 2023 Mar;23(1):100735
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
Wang J, Zhao J, Ma F, Gong L, Lu Y, Xiao W, Tang H, Gao C, Chen Y, Ma J, Gao Z, Yan J, Han S
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(11):e2204238
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(11):e2204238
miR‑222-3p reduces neuronal cell apoptosis and alleviates spinal cord injury by inhibiting Bbc3 and Bim.
Zhang Q, Li G, Kong J, Dai J, Fan Z, Li J
Neuroscience research 2023 Mar;188:39-50
Neuroscience research 2023 Mar;188:39-50
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Zhang L, Ma X, Shi R, Zhang L, Zhao R, Duan R, Qin Y, Gao S, Li X, Duan J, Li J
British journal of pharmacology 2023 Mar;180(5):628-646
British journal of pharmacology 2023 Mar;180(5):628-646
Neuroprotective effects of oxymatrine on hypoxic-ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway.
Lan XB, Ni YS, Liu N, Wei W, Liu Y, Yang JM, Ma L, Bai R, Zhang J, Yu JQ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114266
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Mar;159:114266
GDNF-Loaded Polydopamine Nanoparticles-Based Anisotropic Scaffolds Promote Spinal Cord Repair by Modulating Inhibitory Microenvironment.
Ma J, Li J, Wang X, Li M, Teng W, Tao Z, Xie J, Ma Y, Shi Q, Li B, Saijilafu
Advanced healthcare materials 2023 Mar;12(8):e2202377
Advanced healthcare materials 2023 Mar;12(8):e2202377
Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling.
Feng F, Zhao Z, Cai X, Heng X, Ma X
Cancer medicine 2023 Mar;12(5):5889-5907
Cancer medicine 2023 Mar;12(5):5889-5907
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
Jiang Y, Li Y, Zhang Y, Hu D, Zhang S, Wang C, Huang S, Zhang A, Jia Z, You R
International immunopharmacology 2023 Mar;116:109847
International immunopharmacology 2023 Mar;116:109847
Dioscin ameliorates silica-aggravated systemic lupus erythematosus via suppressing apoptosis and improving LC3-associated phagocytosis in MRL/lpr mice.
Zhang P, Lei X, Ou L, Cheng Y, Miao Q, Li C, Chen Y
International immunopharmacology 2023 Mar;116:109814
International immunopharmacology 2023 Mar;116:109814
pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway.
Zong Q, Pan Y, Liu Y, Wu Z, Huang Z, Zhang Y, Ma K
International immunopharmacology 2023 Mar;116:109727
International immunopharmacology 2023 Mar;116:109727
SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.
Yang J, Chen X
Immunity, inflammation and disease 2023 Mar;11(3):e809
Immunity, inflammation and disease 2023 Mar;11(3):e809
SKA1 is overexpressed in laryngocarcinoma and modulates cell growth via P53 signaling pathway.
Li Z, Liu J, Peng H, Li C, Liu Y, Xie W
Cell cycle (Georgetown, Tex.) 2023 Mar-Mar;22(6):693-704
Cell cycle (Georgetown, Tex.) 2023 Mar-Mar;22(6):693-704
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
Zhao H, Tang S, Tao Q, Ming T, Lei J, Liang Y, Peng Y, Wang M, Liu M, Yang H, Ren S, Xu H
Journal of agricultural and food chemistry 2023 Mar 8;71(9):3981-3993
Journal of agricultural and food chemistry 2023 Mar 8;71(9):3981-3993
Autophagy-Targeted Calcium Phosphate Nanoparticles Enable Transarterial Chemoembolization for Enhanced Cancer Therapy.
Yuan G, Xu Y, Bai X, Wang W, Wu X, Chen J, Li J, Jia X, Gu Z, Zhang X, Hu W, Wang J, Liu Y, Zhu XM
ACS applied materials & interfaces 2023 Mar 8;15(9):11431-11443
ACS applied materials & interfaces 2023 Mar 8;15(9):11431-11443
Semaglutide inhibits ischemia/reperfusion-induced cardiomyocyte apoptosis through activating PKG/PKCε/ERK1/2 pathway.
Zhu Q, Luo Y, Wen Y, Wang D, Li J, Fan Z
Biochemical and biophysical research communications 2023 Mar 5;647:1-8
Biochemical and biophysical research communications 2023 Mar 5;647:1-8
The Wnt/β-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury.
Chen Z, He S, Lian S, Shen Y, Jiang W, Zhou L, Zhou L, Zhang X
Bioscience reports 2023 Mar 31;43(3)
Bioscience reports 2023 Mar 31;43(3)
PTMA binds to HMGB1 to regulate mitochondrial oxidative phosphorylation and thus affect the malignant progression of esophageal squamous cell carcinoma.
Chen S, He R, Lin X, Zhang W, Chen H, Xu R, Kang M
Journal of thoracic disease 2023 Mar 31;15(3):1302-1318
Journal of thoracic disease 2023 Mar 31;15(3):1302-1318
CPT1A modulates PI3K/Akt/mTOR pathway to promote preeclampsia.
Chen M, Chao B, Xu J, Liu Z, Tao Y, He J, Wang J, Yang H, Luo X, Qi H
Placenta 2023 Mar 3;133:23-31
Placenta 2023 Mar 3;133:23-31
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation.
Yang A, Yan S, Yin Y, Chen C, Tang X, Ran M, Chen B
International journal of molecular sciences 2023 Mar 24;24(7)
International journal of molecular sciences 2023 Mar 24;24(7)
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Tian Y, Che H, Yang J, Jin Y, Yu H, Wang C, Fu Y, Li N, Zhang J
Toxins 2023 Mar 21;15(3)
Toxins 2023 Mar 21;15(3)
Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.
Wan W, Miao Y, Niu Y, Zhu K, Ma Y, Pan M, Ma B, Wei Q
Stem cell research & therapy 2023 Mar 20;14(1):46
Stem cell research & therapy 2023 Mar 20;14(1):46
Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes.
Li J, Hui Y, Xu Z, Tan J, Yin K, Kuang L, Tang Y, Wei J, Zhong Q, Zheng T
iScience 2023 Mar 17;26(3):106271
iScience 2023 Mar 17;26(3):106271
The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway.
Ge F, Gao X, Zhou X, Li J, Ma X, Huang M, Wuken S, Tu P, An C, Chai X
Chinese medicine 2023 Mar 17;18(1):29
Chinese medicine 2023 Mar 17;18(1):29
Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway.
Wu ZS, Luo HL, Chuang YC, Lee WC, Wang HJ, Chancellor MB
Biomedicines 2023 Mar 17;11(3)
Biomedicines 2023 Mar 17;11(3)
Dietary Lactobacillus reuteri prevent from inflammation mediated apoptosis of liver via improving intestinal microbiota and bile acid metabolism.
Lin Z, Wu J, Wang J, Levesque CL, Ma X
Food chemistry 2023 Mar 15;404(Pt B):134643
Food chemistry 2023 Mar 15;404(Pt B):134643
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
Li Y, She W, Xu X, Liu Y, Wang X, Tian S, Li S, Wang M, Yu C, Liu P, Huang T, Wei Y
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
MiR-214-3p may alleviate T-2 toxin-induced chondrocyte apoptosis and matrix degradation by regulating NF-κB signaling pathway in vitro.
Liu L, Zhang H, Jin B, Li H, Zheng X, Li X, Li M, Li M, Nian S, Wang K
Toxicon : official journal of the International Society on Toxinology 2023 Mar 15;225:107049
Toxicon : official journal of the International Society on Toxinology 2023 Mar 15;225:107049
Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.
Feng L, Luo G, Li Y, Zhang C, Liu Y, Liu Y, Chen H, He D, Zhu Y, Gan L
Veterinary research 2023 Mar 14;54(1):25
Veterinary research 2023 Mar 14;54(1):25
Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.
Zhao C, Liu Z, Chang CC, Chen YC, Zhang Q, Zhang XD, Andreou C, Pang J, Liu ZX, Wang DY, Kircher MF, Yang J
ACS nano 2023 Mar 14;17(5):4261-4278
ACS nano 2023 Mar 14;17(5):4261-4278
Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.
Rahman KU, Yang S, Azam N, Yuan Z, Yu J, Zhao C, Feng B
Cancers 2023 Mar 11;15(6)
Cancers 2023 Mar 11;15(6)
Mechanism Repositioning Based on Integrative Pharmacology: Anti-Inflammatory Effect of Safflower in Myocardial Ischemia-Reperfusion Injury.
Zhao F, Jiang H, Zhang T, Chen H, Li W, Li X, Wang P, Xu H
International journal of molecular sciences 2023 Mar 10;24(6)
International journal of molecular sciences 2023 Mar 10;24(6)
Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells.
Tao Y, Wu Y, Jiang C, Wang Q, Geng X, Chen L, Zhou S, Wang X, Han M, Du D, Ding B, Li X
Journal of hypertension 2023 Mar 1;41(3):393-401
Journal of hypertension 2023 Mar 1;41(3):393-401
Dexpramipexole ameliorates cognitive deficits in sepsis-associated encephalopathy through suppressing mitochondria-mediated pyroptosis and apoptosis.
Zhang Y, Fu Q, Ruan J, Shi C, Lu W, Wu J, Zhou Z
Neuroreport 2023 Mar 1;34(4):220-231
Neuroreport 2023 Mar 1;34(4):220-231
Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.
Fang X, Zhang X, Zhang Y, Zhang X, Shan M, Guan S, Qiu Z, Zhu D, Luo H
Journal of ethnopharmacology 2023 Mar 1;303:115978
Journal of ethnopharmacology 2023 Mar 1;303:115978
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells.
Yao J, Takenaga K, Koshikawa N, Kida Y, Lin J, Watanabe T, Maru Y, Hippo Y, Yamamoto S, Zhu Y, Nagase H
International journal of cancer 2023 Mar 1;152(5):962-976
International journal of cancer 2023 Mar 1;152(5):962-976
Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival.
Li D, Zhao S, Zhu B, Zhao W, Ding Y, Li X, Fu D, Yu H, Wang B, Pan T
Drug development research 2023 Jun;84(4):736-746
Drug development research 2023 Jun;84(4):736-746
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S
Molecular carcinogenesis 2023 Jun;62(6):866-881
Molecular carcinogenesis 2023 Jun;62(6):866-881
miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.
Wang X, Yang J, Li H, Mu H, Zeng L, Cai S, Su P, Li H, Zhang L, Xiang W
Redox biology 2023 Jun;62:102684
Redox biology 2023 Jun;62:102684
Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.
Xu T, Gao P, Huang Y, Wu M, Yi J, Zhou Z, Zhao X, Jiang T, Liu H, Qin T, Yang Z, Wang X, Bao T, Chen J, Zhao S, Yin G
Redox biology 2023 Jun;62:102682
Redox biology 2023 Jun;62:102682
Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2.
Fu F, Chen C, Du K, Li LS, Li R, Lei TY, Deng Q, Wang D, Yu QX, Yang X, Han J, Pan M, Zhen L, Zhang LN, Li J, Li FT, Zhang YL, Jing XY, Li FC, Li DZ, Liao C
Molecular neurobiology 2023 Jun;60(6):2986-3003
Molecular neurobiology 2023 Jun;60(6):2986-3003
taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.
Zhou Q, Zheng Z, Wang X, Li W, Wang L, Yin C, Zhang Q, Wang Q
Neurochemical research 2023 Jun;48(6):1848-1863
Neurochemical research 2023 Jun;48(6):1848-1863
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation.
Cheng Y, Fan H, Liu K, Liu J, Zou H, You Z
Cell biology international 2023 Jun;47(6):1092-1105
Cell biology international 2023 Jun;47(6):1092-1105
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway.
Song QQ, Lin LP, Chen YL, Qian JC, Wei K, Su JW, Ding JH, Lu M, Liu Y, Tan RX, Hu G
Acta pharmacologica Sinica 2023 Jun;44(6):1262-1276
Acta pharmacologica Sinica 2023 Jun;44(6):1262-1276
Hypobaric Hypoxia Aggravates Renal Injury by Inducing the Formation of Neutrophil Extracellular Traps through the NF-κB Signaling Pathway.
Wei JY, Hu MY, Chen XQ, Wei JS, Chen J, Qin XK, Lei FY, Zou JS, Zhu SQ, Qin YH
Current medical science 2023 Jun;43(3):469-477
Current medical science 2023 Jun;43(3):469-477
Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis.
Wei Y, Sun L, Liu C, Li L
Naunyn-Schmiedeberg's archives of pharmacology 2023 Jun;396(6):1155-1169
Naunyn-Schmiedeberg's archives of pharmacology 2023 Jun;396(6):1155-1169
Hawthorn fruit extract protect against MC-LR-induced hepatotoxicity by attenuating oxidative stress and apoptosis.
Wang Y, Guo Y, Liu H, Du X, Shi L, Wang W, Zhang S
Environmental toxicology 2023 Jun;38(6):1239-1250
Environmental toxicology 2023 Jun;38(6):1239-1250
Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance.
Zhang M, Wang L, Jin H, Zhao N, Liu Y, Lan S, Liu S, Zhang H
Journal of controlled release : official journal of the Controlled Release Society 2023 Jun;358:612-625
Journal of controlled release : official journal of the Controlled Release Society 2023 Jun;358:612-625
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Liu Z, Xiang H, Deng Q, Fu W, Li Y, Yu Z, Qiu Y, Mei Z, Xu L
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
Nephrology (Carlton, Vic.) 2023 Jun;28(6):315-327
1,4,5,6,7,8‑Hexahydropyrido[4,3‑d]pyrimidine inhibits HepG2 cell proliferation, migration and invasion, and induces apoptosis through the upregulation of miR‑26b‑5p by targeting CDK8.
Luo H, Yang Y, Zhou Y, Bai X, Hou Y
Oncology letters 2023 Jun;25(6):260
Oncology letters 2023 Jun;25(6):260
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
αCGRP deficiency aggravates pulmonary fibrosis by activating the PPARγ signaling pathway.
Lv X, Chen Q, Zhang Z, Du K, Huang Y, Li X, Zeng Y
Genes and immunity 2023 Jun;24(3):139-148
Genes and immunity 2023 Jun;24(3):139-148
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, Xue NJ, Chen Y, Zhang BR, Pu JL
Aging cell 2023 Jun;22(6):e13834
Aging cell 2023 Jun;22(6):e13834
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Wang HL, Cheng YC, Yeh TH, Liu HF, Weng YH, Chen RS, Chen YC, Lu JC, Hwang TL, Wei KC, Liu YC, Wang YT, Hsu CC, Chiu TJ, Chiu CC
Biochemical pharmacology 2023 Jun;212:115524
Biochemical pharmacology 2023 Jun;212:115524
Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway.
Yang Y, Mei C, Xian H, Zhang X, Li J, Liang ZX, Zhi Y, Ma Y, Wang HJ
Veterinary and comparative oncology 2023 Jun;21(2):315-326
Veterinary and comparative oncology 2023 Jun;21(2):315-326
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
Deng H, Chen W, Zhang B, Zhang Y, Han L, Zhang Q, Yao S, Wang H, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3(+)CD4(+)T cells against PAHs carcinogenicity.
Chen C, Lim D, Cai Z, Zhang F, Liu G, Dong C, Feng Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113783
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113783
Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
Zhang C, Wang M, Ying Y, Meng F, Gao H, Zeng S, Zhu Y, Liu A, Zhang Z, Xu C
Cancer medicine 2023 Jun;12(11):12581-12592
Cancer medicine 2023 Jun;12(11):12581-12592
Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin.
Wan J, Zhu Z, He Z, Wu H, Chen A, Zhu W, Cheng P
International immunopharmacology 2023 Jun;119:110261
International immunopharmacology 2023 Jun;119:110261
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
Xue K, Zhang G, Zhou Y, Wang K, Yao Z, Chen J, Zhang Y, Li Z, Li Z, Zheng Z, Feng Y, Mao C, Lin C, Xia W
International immunopharmacology 2023 Jun;119:110204
International immunopharmacology 2023 Jun;119:110204
TWIST1 rescue calcium overload and apoptosis induced by inflammatory microenvironment in S. aureus-induced osteomyelitis.
Wang Y, Dai G, Lin Z, Cheng C, Zhou X, Song M, Chen P, Ma S, Hu Y, Liu G, Yu B
International immunopharmacology 2023 Jun;119:110153
International immunopharmacology 2023 Jun;119:110153
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Yu J, Zhao X, Yan X, Li W, Liu Y, Wang J, Wang J, Yang Y, Hao Y, Liang Z, Tao Y, Yuan Y, Du Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy.
Peng X, Tang S, Tang D, Zhou D, Li Y, Chen Q, Wan F, Lukas H, Han H, Zhang X, Gao W, Wu S
Science advances 2023 Jun 9;9(23):eadh1736
Science advances 2023 Jun 9;9(23):eadh1736
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Wu Y, Duan Z, Qu L, Zhang Y, Zhu C, Fan D
Food & function 2023 Jun 6;14(11):5167-5181
Food & function 2023 Jun 6;14(11):5167-5181
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
SNORD6 promotes cervical cancer progression by accelerating E6-mediated p53 degradation.
Li Q, Xie B, Chen X, Lu B, Chen S, Sheng X, Zhao Y
Cell death discovery 2023 Jun 27;9(1):192
Cell death discovery 2023 Jun 27;9(1):192
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells.
Liu X, Zhao T, Shi Z, Hu C, Li Q, Sun C
Molecules (Basel, Switzerland) 2023 Jun 23;28(13)
Molecules (Basel, Switzerland) 2023 Jun 23;28(13)
Effect of Lactobacillus delbrueckii subsp. lactis on vaginal radiotherapy for gynecological cancer.
Bi Z, Wang Q, Yang T, Liu Y, Yuan J, Li L, Guo Y
Scientific reports 2023 Jun 21;13(1):10105
Scientific reports 2023 Jun 21;13(1):10105
[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].
Zheng Q, Shao Y, Zheng W, Zou Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jun 20;43(6):873-878
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jun 20;43(6):873-878
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Duan S, Xia Y, Tian X, Cui J, Zhang X, Yang Q, Zhao T, Lin Y, Zhang F, Zhang X, Cen J
Carbohydrate polymers 2023 Jun 15;310:120695
Carbohydrate polymers 2023 Jun 15;310:120695
Sodium houttuyfonate exerts its neuroprotection effect by inhibiting the M1 microglia polarization in a TLR4/NF-κB signal pathway.
Tang W, Liu L, Yan Y, Xia Y
Brain research 2023 Jun 15;1809:148358
Brain research 2023 Jun 15;1809:148358
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p.
Chen X, He H, Long B, Wei B, Yang P, Huang X, Wang Q, Lin J, Tang H
Biological research 2023 Jun 12;56(1):31
Biological research 2023 Jun 12;56(1):31
Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner.
Sabry R, Williams M, LaMarre J, Favetta LA
Experimental cell research 2023 Jun 1;427(1):113574
Experimental cell research 2023 Jun 1;427(1):113574
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Li C, Hao J, Qiu H, Xin H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
The Aldose Reductase Inhibitor Epalrestat Maintains Blood-Brain Barrier Integrity by Enhancing Endothelial Cell Function during Cerebral Ischemia.
Zhang T, Wu J, Yao X, Zhang Y, Wang Y, Han Y, Wu Y, Xu Z, Lan J, Han S, Zou H, Sun Q, Wang D, Zhang J, Wang G
Molecular neurobiology 2023 Jul;60(7):3741-3757
Molecular neurobiology 2023 Jul;60(7):3741-3757
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Liang JP, He YM, Cui YL, Sun YN, He GS, Zhu ZG, Mao XL
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Li J, Xiao X, Ou Y, Cao L, Guo M, Qi C, Wang Z, Liu Y, Shuai Q, Wang H, Sun P, Shi Y, Yang G, Yang S
Cancer communications (London, England) 2023 Jul;43(7):765-787
Cancer communications (London, England) 2023 Jul;43(7):765-787
Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p.
Ni Z, Liu W, Pan G, Mao A, Liu J, Zhang Q, Li J, Liu L, Li H
Environmental toxicology 2023 Jul;38(7):1712-1722
Environmental toxicology 2023 Jul;38(7):1712-1722
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Liang C, Yi K, Zhou X, Li X, Zhong C, Cao H, Xie C, Zhu J
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
ATPIF1 alleviates oxygen glucose deprivation/reoxygenation-induced astrocyte injury in vitro: A rat model of ischemic brain injury.
Wei Z, Wu R, Zhang L, Xu P
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):791-802
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):791-802
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.
Kuang H, Sun X, Liu Y, Tang M, Wei Y, Shi Y, Li R, Xiao G, Kang J, Wang F, Peng J, Xu H, Zhou F
The FEBS journal 2023 Jul;290(14):3664-3687
The FEBS journal 2023 Jul;290(14):3664-3687
Periostin regulates LPS-induced apoptosis via Nrf2/HO-1 pathway in periodontal ligament fibroblasts.
Jiang Y, Yang P, Li C, Lu Y, Kou Y, Liu H, Guo J, Li M
Oral diseases 2023 Jul;29(5):2188-2204
Oral diseases 2023 Jul;29(5):2188-2204
Thioredoxin1 is a target to attenuate diabetes‑induced RPE cell dysfunction in human ARPE19 cells by alleviating oxidative stress.
Qi H, Liu T, Liu J, Teng Q, Ma Z, Wang S, Wen S, Zhang C, Ren X, Kong H, Kong L
Molecular medicine reports 2023 Jul;28(1)
Molecular medicine reports 2023 Jul;28(1)
CX3CL1/CX3CR1 axis alleviates inflammation and apoptosis in human nucleus pulpous cells via M2 macrophage polarization.
Gao XW, Hu HL, Xie MH, Tang CX, Ou J, Lu ZH
Experimental and therapeutic medicine 2023 Jul;26(1):359
Experimental and therapeutic medicine 2023 Jul;26(1):359
Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments.
Zhou L, Peng F, Li J, Gong H
Experimental and therapeutic medicine 2023 Jul;26(1):325
Experimental and therapeutic medicine 2023 Jul;26(1):325
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Kogami M, Abe S, Nakamura H, Aoshiba K
Oncology letters 2023 Jul;26(1):313
Oncology letters 2023 Jul;26(1):313
Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression.
Zhang J, Liu Y, Wang X, Wang Z, Xing E, Li J, Wang D
Oncology letters 2023 Jul;26(1):307
Oncology letters 2023 Jul;26(1):307
Integration of proteomics and network toxicology reveals the mechanism of mercury chloride induced hepatotoxicity, in mice and HepG2 cells.
Cao X, Mao K, Zhang Y, Yang M, Liu H, Wang X, Hao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113820
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113820
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Qin Y, Shi Y, Yu Q, Yang S, Wang Y, Dai X, Li G, Cheng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Chen G, She W, Yu C, Rouzi T, Li X, Ma L, Zhang N, Jiang H, Liu X, Wu J, Wang Q, Shen H, Zhou F
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p.
Duan J, Li H, Wang C, Yao J, Jin Y, Zhao J, Zhang Y, Liu M, Sun H
International immunopharmacology 2023 Jul;120:110319
International immunopharmacology 2023 Jul;120:110319
Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.
Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295
International immunopharmacology 2023 Jul;120:110295
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
Chen Z, Song Y, Li P, Gao W
Cellular signalling 2023 Jul;107:110685
Cellular signalling 2023 Jul;107:110685
The protective effect of lncRNA NEAT1/miR-122-5p/Wnt1 axis on hippocampal damage in hepatic ischemic reperfusion young mice.
Dong Z, Jia L, Han W, Wang Y, Sheng M, Ren Y, Weng Y, Li H, Yu W
Cellular signalling 2023 Jul;107:110668
Cellular signalling 2023 Jul;107:110668
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Wang Y, Ying X, Wang Y, Zou Z, Yuan A, Xiao Z, Geng N, Qiao Z, Li W, Lu X, Pu J
Cellular signalling 2023 Jul;107:110655
Cellular signalling 2023 Jul;107:110655
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Ge J, Song J, Sun B, Yang X, Du B, Sun X, Zhang J, Ge J, Xie H
Mutation research 2023 Jul-Dec;827:111829
Mutation research 2023 Jul-Dec;827:111829
Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury.
Hu H, Cheng X, Li F, Guan Z, Xu J, Wu D, Gao Y, Zhan X, Wang P, Zhou H, Rao Z, Cheng F
Cell death discovery 2023 Jul 8;9(1):236
Cell death discovery 2023 Jul 8;9(1):236
Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1.
Liu C, Gao X, Lou J, Li H, Chen Y, Chen M, Zhang Y, Hu Z, Chang X, Luo M, Zhai Y, Li C
Arthritis research & therapy 2023 Jul 7;25(1):117
Arthritis research & therapy 2023 Jul 7;25(1):117
Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.
Zhou W, Wang C, Zhang B, Gou S
European journal of pharmacology 2023 Jul 5;950:175751
European journal of pharmacology 2023 Jul 5;950:175751
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Shen ZB, Meng HW, Meng XS, Lv ZK, Fang MY, Zhang LL, Lv ZL, Li MS, Liu AK, Han JH, Li QS, Duan YJ
European journal of medicinal chemistry 2023 Jul 5;255:115417
European journal of medicinal chemistry 2023 Jul 5;255:115417
Downregulation of CLDN6 inhibits cell migration and invasion and promotes apoptosis by regulation of the JAK2/STAT3 signaling pathway in hepatocellular carcinoma.
He Z, Fan F, Xu Z, Zhang M, Zhao R, Ke X, Wang Q, Yan S, Zheng H
Translational cancer research 2023 Jul 31;12(7):1753-1764
Translational cancer research 2023 Jul 31;12(7):1753-1764
Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.
Liu C, Wu J, Li M, Gao R, Zhang X, Ye-Lehmann S, Song J, Zhu T, Chen C
Journal of neuroinflammation 2023 Jul 28;20(1):175
Journal of neuroinflammation 2023 Jul 28;20(1):175
USP18 overexpression protects against spinal cord ischemia/reperfusion injury via regulating autophagy.
Yuan L, Xu J, Qin F, Yi X, Zhong Z, Gu X, Gong G
Neuroscience letters 2023 Jul 27;810:137359
Neuroscience letters 2023 Jul 27;810:137359
Neobavaisoflavone induces pyroptosis of liver cancer cells via Tom20 sensing the activated ROS signal.
Li Y, Zhao R, Xiu Z, Yang X, Zhu Y, Han J, Li S, Li Y, Sun L, Li X, Jin N, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154869
SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes.
Chang Y, Wang C, Zhu J, Zheng S, Sun S, Wu Y, Jiang X, Li L, Ma R, Li G
Journal of translational medicine 2023 Jul 22;21(1):494
Journal of translational medicine 2023 Jul 22;21(1):494
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
Pei Z, Zhou R, Yao W, Dong S, Liu Y, Gao Z
iScience 2023 Jul 21;26(7):107080
iScience 2023 Jul 21;26(7):107080
Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression.
Zhang CT, Qin DL, Cao XY, Kan JS, Huang XX, Gao DS, Gao J
iScience 2023 Jul 21;26(7):107049
iScience 2023 Jul 21;26(7):107049
NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling.
Tong Q, Yan D, Cao Y, Dong X, Abula Y, Yang H, Kong P, Yi M
Scientific reports 2023 Jul 21;13(1):11795
Scientific reports 2023 Jul 21;13(1):11795
Novel Protein C6ORF120 Promotes Apoptosis through Mitochondria-dependent Pathway in CD4 (+)T Lymphocytes.
Liu H, Wang X, Wang P, Wang YQ, Yi YY, Li X
Biomedical and environmental sciences : BES 2023 Jul 20;36(7):639-643
Biomedical and environmental sciences : BES 2023 Jul 20;36(7):639-643
NCOA7 Regulates Growth and Metastasis of Clear Cell Renal Cell Carcinoma via MAPK/ERK Signaling Pathway.
Guo J, Ke S, Chen Q, Zhou J, Guo J, Qiu T
International journal of molecular sciences 2023 Jul 18;24(14)
International journal of molecular sciences 2023 Jul 18;24(14)
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Xu W, Yuan Y, Tian Y, Cheng C, Chen Y, Zeng L, Yuan Y, Li D, Zheng L, Luo T
Journal of hazardous materials 2023 Jul 15;454:131470
Journal of hazardous materials 2023 Jul 15;454:131470
MiR-29c-5p regulates the function of buffalo granulosa cells to induce follicular atresia by targeting INHBA.
Cheng J, Wei Y, Zhao Z, Xing Q, Gao Z, Cheng J, Yu C, Pan Y, Yang Y, Shi D, Deng Y
Theriogenology 2023 Jul 15;205:50-62
Theriogenology 2023 Jul 15;205:50-62
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Wan Q, Xu J, Zhu C, Liu X, Tu Y, Lei J, Yu J
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Yue P, Lv X, You J, Zou Y, Luo J, Lu Z, Cao H, Liu Z, Fan X, Ye Q
Cellular & molecular biology letters 2023 Jul 12;28(1):55
Cellular & molecular biology letters 2023 Jul 12;28(1):55
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Gao Q, Flint TR, Young L, Connell CM, Lukey MJ, Goncalves MD, White EP, Venkitaraman AR, Janowitz T
Cell metabolism 2023 Jul 11;35(7):1147-1162.e7
Cell metabolism 2023 Jul 11;35(7):1147-1162.e7
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells.
Gao Y, Liu T, Liu J, Yang Y, Sun K, Li Z, Zhai X, Zuo D
Chemico-biological interactions 2023 Jul 1;379:110516
Chemico-biological interactions 2023 Jul 1;379:110516
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma.
Chen X, Zhang L, Wang X, Xu L, Sun J, Liu Y, Liu X, Kalvakolanu DV, Guo B
Anti-cancer drugs 2023 Jul 1;34(6):715-724
Anti-cancer drugs 2023 Jul 1;34(6):715-724
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Lin JP, Huang MH, Sun ZT, Chen L, Lei YH, Huang YQ, Qi M, Fan SR, Chen SG, Chung CW, Chan MC, Liu JS, Hu M, Chen MF, Ye WC, Chen YY, Deng LJ
Life sciences 2023 Jul 1;324:121715
Life sciences 2023 Jul 1;324:121715
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Liu WY, Li Y, Li Y, Xu LZ, Jia JP
Molecular neurobiology 2023 Jan;60(1):133-144
Molecular neurobiology 2023 Jan;60(1):133-144
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus.
Yin H, Chen XT, Chi QN, Ma YN, Fu XY, Du SS, Qi YK, Wang KW
Acta pharmacologica Sinica 2023 Jan;44(1):201-210
Acta pharmacologica Sinica 2023 Jan;44(1):201-210
Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study.
Li H, Wang C, Jin Y, Cai Y, Yao J, Meng Q, Wu J, Wang H, Sun H, Liu M
Phytotherapy research : PTR 2023 Jan;37(1):231-251
Phytotherapy research : PTR 2023 Jan;37(1):231-251
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway.
Ma T, Zhang H, Li T, Bai J, Wu Z, Cai T, Chen Y, Xia X, Du Y, Fu W
Phytotherapy research : PTR 2023 Jan;37(1):181-194
Phytotherapy research : PTR 2023 Jan;37(1):181-194
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Zhang L, Zhang X, Che D, Zeng L, Zhang Y, Nan K, Zhang X, Zhang H, Guo Z
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Melatonin Increases Proliferation and Decreases Apoptosis of GC-1 spg Cells by Upregulating the Expression of circTec.
Xu C, Yang H, Li C, Wu Z, Ma Y
Reproductive sciences (Thousand Oaks, Calif.) 2023 Jan;30(1):135-144
Reproductive sciences (Thousand Oaks, Calif.) 2023 Jan;30(1):135-144
Metabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury.
Luo Y, Chen P, Yang L, Duan X
Molecular medicine reports 2023 Jan;27(1)
Molecular medicine reports 2023 Jan;27(1)
Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway.
Ye Z, Xia Y, Li L, Li B, Chen W, Han S, Zhou X, Chen L, Yu W, Ruan Y, Cheng F
Translational oncology 2023 Jan;27:101578
Translational oncology 2023 Jan;27:101578
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Protective Mechanism of Ethyl Gallate against Intestinal Ischemia-Reperfusion Injury in Mice by in Vivo and in Vitro Studies Based on Transcriptomics.
Fan S, Feng X, Li K, Li B, Diao Y
Chemistry & biodiversity 2023 Jan;20(1):e202200643
Chemistry & biodiversity 2023 Jan;20(1):e202200643
Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease.
Wang L, Zhou BQ, Li YH, Jiang QQ, Cong WH, Chen KJ, Wen XM, Wu ZZ
Neural regeneration research 2023 Jan;18(1):226-232
Neural regeneration research 2023 Jan;18(1):226-232
Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.
Liu C, Liu Z, Fang Y, Liao Z, Zhang Z, Yuan X, Yu T, Yang Y, Xiong M, Zhang X, Zhang G, Meng L, Zhang Z
Environment international 2023 Jan;171:107696
Environment international 2023 Jan;171:107696
Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.
Feng Y, Yang L, Ma X, Huang Z, Zong X, Citadin CT, Lin HW, Zhang Q
Neurochemistry international 2023 Jan;162:105464
Neurochemistry international 2023 Jan;162:105464
CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L
The international journal of biochemistry & cell biology 2023 Jan;154:106344
The international journal of biochemistry & cell biology 2023 Jan;154:106344
HAPLN3 inhibits apoptosis and promotes EMT of clear cell renal cell carcinoma via ERK and Bcl-2 signal pathways.
Ding Y, Xiong S, Chen X, Pan Q, Fan J, Guo J
Journal of cancer research and clinical oncology 2023 Jan;149(1):79-90
Journal of cancer research and clinical oncology 2023 Jan;149(1):79-90
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Li Y, Shen B, Lv C, Zhu X, Naren Q, Xu D, Chen H, Wu F
International immunopharmacology 2023 Jan;114:109489
International immunopharmacology 2023 Jan;114:109489
Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis.
Wu H, Yuan J, Yin H, Jing B, Sun C, Nguepi Tsopmejio IS, Jin Z, Song H
Poultry science 2023 Jan;102(1):102261
Poultry science 2023 Jan;102(1):102261
Heat enhances the inhibitory effect of lipopolysaccharide on duck granulosa cell proliferation and steroid biosynthesis in vitro.
Luo P, Huang XB, Zhan XZ, Yang C, Deng ZC, Zhang C, Fu XL, Tian YB, Huang YM, Liu WJ
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13851
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13851
Berberine enhances autophagic flux by activating the Nrf2 signaling pathway in bovine endometrial epithelial cells to resist LPS-induced apoptosis.
Fu K, Chen H, Mei L, Wang J, Gong B, Li Y, Cao R
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13847
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13847
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.
Yu H, Peng Y, Dong W, Shen B, Yang G, Nie Q, Tian Y, Qin L, Song C, Chen B, Zhao Y, Li L, Hong S
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Zhang Z, Pi R, Jiang Y, Ahmad M, Luo H, Luo J, Yang J, Sun B
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells.
Feng YB, Chen L, Chen FX, Yang Y, Chen GH, Zhou ZH, Xu CF
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231161174
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231161174
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
Liu Y, She W, Li Y, Wang M, Liu Y, Ning B, Xu T, Huang T, Wei Y
Journal of translational medicine 2023 Jan 7;21(1):7
Journal of translational medicine 2023 Jan 7;21(1):7
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Shao D, Gao Z, Zhao Y, Fan M, Zhao X, Wei Q, Pan M, Ma B
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
MitoQ Protects Ovarian Organoids against Oxidative Stress during Oogenesis and Folliculogenesis In Vitro.
Wang J, Du H, Ma L, Feng M, Li L, Zhao X, Dai Y
International journal of molecular sciences 2023 Jan 4;24(2)
International journal of molecular sciences 2023 Jan 4;24(2)
Network and experimental pharmacology on mechanism of Si-Wu-tang improving ovarian function in a mouse model of premature ovarian failure induced by cyclophosphamide.
Liu X, Song Y, Zhou F, Zhang C, Li F, Hu R, Ma W, Song K, Tang Z, Zhang M
Journal of ethnopharmacology 2023 Jan 30;301:115842
Journal of ethnopharmacology 2023 Jan 30;301:115842
Exploring the synergic mechanism of Ligusticum striatum DC. and borneol in attenuating BMECs injury and maintaining tight junctions against cerebral ischaemia based on the HIF-1α/VEGF signalling pathway.
Song X, Xing W, Zhang X, Wang X, Ji J, Lu J, Yu B, Ruan M
Journal of ethnopharmacology 2023 Jan 30;301:115764
Journal of ethnopharmacology 2023 Jan 30;301:115764
Alginate Oligosaccharides Prevent Dextran-Sulfate-Sodium-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Modulating Gut Microbiota.
Wu A, Gao Y, Kan R, Ren P, Xue C, Kong B, Tang Q
Foods (Basel, Switzerland) 2023 Jan 3;12(1)
Foods (Basel, Switzerland) 2023 Jan 3;12(1)
5-Hydroxytryptophan inhibits β-casein biosynthesis and promotes goat mammary epithelial cell apoptosis through the JAK2/STAT5a axis and the HTR7.
Du W, Zhang ZF, Xiao JY, Wang Y, Liu WY, Zheng HL
Journal of animal science 2023 Jan 3;101
Journal of animal science 2023 Jan 3;101
Daidzein ameliorates doxorubicin-induced cardiac injury by inhibiting autophagy and apoptosis in rats.
Wu J, Li K, Liu Y, Feng A, Liu C, Adu-Amankwaah J, Ji M, Ma Y, Hao Y, Bu H, Sun H
Food & function 2023 Jan 23;14(2):934-945
Food & function 2023 Jan 23;14(2):934-945
Glucotropaeolin Promotes Apoptosis by Calcium Dysregulation and Attenuates Cell Migration with FOXM1 Suppression in Pancreatic Cancer Cells.
Lee W, Song G, Bae H
Antioxidants (Basel, Switzerland) 2023 Jan 23;12(2)
Antioxidants (Basel, Switzerland) 2023 Jan 23;12(2)
Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism.
Zhang Y, Wu F, Teng F, Guo S, Li H
International journal of molecular sciences 2023 Jan 20;24(3)
International journal of molecular sciences 2023 Jan 20;24(3)
Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway.
Cheng B, Chu X, Liu R, Ma X, Wang M, Zhang J, Jiao P, Gao Q, Ma W, Zhang Y, Zhao C, Zhou D, Xiao S
Molecular pharmaceutics 2023 Jan 2;20(1):701-710
Molecular pharmaceutics 2023 Jan 2;20(1):701-710
Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Hu J, Jiang W, Zuo J, Shi D, Chen X, Yang X, Zhang W, Ma L, Liu Z, Xing Q
Communications biology 2023 Jan 17;6(1):59
Communications biology 2023 Jan 17;6(1):59
O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury.
Xuefei Y, Dongyan L, Tianming L, Hejuan Z, Jianhua F
Respiratory research 2023 Jan 16;24(1):16
Respiratory research 2023 Jan 16;24(1):16
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Zhang B, Liu S, Sun Y, Xu D
Toxicology 2023 Jan 15;484:153392
Toxicology 2023 Jan 15;484:153392
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Gu S, Wu G, Lu D, Wang Y, Tang L, Zhang W
Toxicology letters 2023 Jan 15;373:172-183
Toxicology letters 2023 Jan 15;373:172-183
Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
Zhang N, Wang F, Zhu L, Chang R, Mok SRS, Peixoto RD, Tang W, Chen Z
Annals of translational medicine 2023 Jan 15;11(1):12
Annals of translational medicine 2023 Jan 15;11(1):12
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
Hu A, Liu J, Wang Y, Zhang M, Guo Y, Qin Y, Liu T, Men Y, Chen Q, Liu T
Scientific reports 2023 Jan 13;13(1):693
Scientific reports 2023 Jan 13;13(1):693
The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer.
Smok-Kalwat J, Mertowska P, Mertowski S, Smolak K, Kozińska A, Koszałka F, Kwaśniewski W, Grywalska E, Góźdź S
International journal of molecular sciences 2023 Jan 12;24(2)
International journal of molecular sciences 2023 Jan 12;24(2)
Dioscin reduced chemoresistance for colon cancer and analysis of sensitizing targets.
Li R, Qin J, Wang Z, Lv F, Guo J, Zhu H, Huang Y
Biochemical and biophysical research communications 2023 Jan 1;638:94-102
Biochemical and biophysical research communications 2023 Jan 1;638:94-102
ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d -GALACTOSE-INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3.
Zhang X, Li F, Ma J, Zhang X, Yin Y
Shock (Augusta, Ga.) 2023 Jan 1;59(1):91-98
Shock (Augusta, Ga.) 2023 Jan 1;59(1):91-98
Effects of chronic realgar exposure on liver lipidome in mice and identification sensitive lipid biomarker model for realgar-induced liver damage.
Huo T, Zhang W, Yang J, Li J, Zhang Y, Guo H, Wu X, Li A, Feng C, Jiang H
Toxicology letters 2023 Jan 1;372:1-13
Toxicology letters 2023 Jan 1;372:1-13
Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1α-BNIP3 mediated mitophagy.
Lin J, Guo Z, Zheng Z, Hou L, Xu J, Liu Q, Du T, Guo F, Jing X
Life sciences 2023 Jan 1;312:121172
Life sciences 2023 Jan 1;312:121172
Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle.
Lyu S, Zhai Y, Zhu X, Shi Q, Chen F, Zhang G, Zhang Z, Wang E
Theriogenology 2023 Jan 1;195:77-84
Theriogenology 2023 Jan 1;195:77-84
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model.
Zhao JK, Hou SJ, Zhao JW, Yu HL, Duan SR
Translational neuroscience 2023 Jan 1;14(1):20220298
Translational neuroscience 2023 Jan 1;14(1):20220298
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Yang J, Han F, Wu G, Dong Y, Su H, Xu J, Li J
Digestive diseases and sciences 2023 Feb;68(2):478-486
Digestive diseases and sciences 2023 Feb;68(2):478-486
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Pang H, Lei D, Huang J, Guo Y, Fan C
Molecular and cellular probes 2023 Feb;67:101896
Molecular and cellular probes 2023 Feb;67:101896
Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1.
Jian Y, Yang Y, Cheng L, Yang X, Liu H, Li W, Wan Y, Yang D
Cell proliferation 2023 Feb;56(2):e13362
Cell proliferation 2023 Feb;56(2):e13362
Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus.
Zhang X, Cui Y, Song X, Jin X, Sheng X, Xu X, Li T, Chen H, Gao L
Environmental toxicology 2023 Feb;38(2):300-311
Environmental toxicology 2023 Feb;38(2):300-311
Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway.
Chen J, Jiang Z, Liu X, Wang K, Fan W, Chen T, Li Z, Lin D
Phytotherapy research : PTR 2023 Feb;37(2):424-437
Phytotherapy research : PTR 2023 Feb;37(2):424-437
DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370.
Zhou X, He Y, Pan X, Quan H, He B, Li Y, Bai G, Li N, Zhang Z, Zhang H, Li J, Yuan X
Cell death and differentiation 2023 Feb;30(2):576-588
Cell death and differentiation 2023 Feb;30(2):576-588
Corilagin alleviates intestinal ischemia/reperfusion injury by relieving oxidative stress and apoptosis via AMPK/Sirt1-autophagy pathway.
Li B, Li W, Zheng M, Wang Y, Diao Y, Mou X, Liu J
Experimental biology and medicine (Maywood, N.J.) 2023 Feb;248(4):317-326
Experimental biology and medicine (Maywood, N.J.) 2023 Feb;248(4):317-326
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Chen B, Zheng D, Liu C, Bhandari A, Hirachan S, Shen C, Mainali S, Li H, Jiang W, Xu J, Zhang X, Tang K, Zhang W
Pathology, research and practice 2023 Feb;242:154325
Pathology, research and practice 2023 Feb;242:154325
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Li Y, She W, Guo T, Huang T, Liu Y, Liu P, Xu X, Wang X, Wang M, Yu C, Liu Y, Wei Y
Biochemical pharmacology 2023 Feb;208:115404
Biochemical pharmacology 2023 Feb;208:115404
Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke.
Zhu ZH, Jia F, Ahmed W, Zhang GL, Wang H, Lin CQ, Chen WH, Chen LK
Neural regeneration research 2023 Feb;18(2):404-409
Neural regeneration research 2023 Feb;18(2):404-409
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons.
Yan WT, Zhao WJ, Hu XM, Ban XX, Ning WY, Wan H, Zhang Q, Xiong K
Neural regeneration research 2023 Feb;18(2):357-363
Neural regeneration research 2023 Feb;18(2):357-363
Polyphenol-driven facile assembly of a nanosized acid fibroblast growth factor-containing coacervate accelerates the healing of diabetic wounds.
Tong MQ, Lu CT, Huang LT, Yang JJ, Yang ST, Chen HB, Xue PP, Luo LZ, Yao Q, Xu HL, Zhao YZ
Acta biomaterialia 2023 Feb;157:467-486
Acta biomaterialia 2023 Feb;157:467-486
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Fu Y, Song Y, Zhang J, Wei LP, Sun XR
Journal of reproductive immunology 2023 Feb;155:103784
Journal of reproductive immunology 2023 Feb;155:103784
Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.
Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597
Taxifolin ameliorates cigarette smoke-induced chronic obstructive pulmonary disease via inhibiting inflammation and apoptosis.
Liu X, Ma Y, Luo L, Zeng Z, Zong D, Chen Y
International immunopharmacology 2023 Feb;115:109577
International immunopharmacology 2023 Feb;115:109577
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Gong MJ, Zhang HB, Lou M, Wang YS, Ma RP, Hu ZZ, Zheng GX, Zhang Y
Immunity, inflammation and disease 2023 Feb;11(2):e788
Immunity, inflammation and disease 2023 Feb;11(2):e788
Low temperature exposure inhibits proliferation and induces apoptosis of bovine subcutaneous preadipocytes via p38 MAPK/JNK activation.
Li T, Bai H, Yang L, Hao W, Wei S, Yan P
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110813
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110813
Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway.
Lei Z, Ali I, Yang M, Yang C, Li Y, Li L
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
Antioxidants (Basel, Switzerland) 2023 Feb 9;12(2)
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
Li WY, Yang F, Li X, Wang LW, Wang Y
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
Spleen Toxicity of Organophosphorus Flame Retardant TDCPP in Mice and the Related Mechanisms.
Cao L, Wei L, Du Q, Su Y, Ye S, Liu K
Toxics 2023 Feb 27;11(3)
Toxics 2023 Feb 27;11(3)
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Wu J, Xiao D, Yu K, Shalamu K, He B, Zhang M
Acta biochimica et biophysica Sinica 2023 Feb 25;55(2):285-294
Acta biochimica et biophysica Sinica 2023 Feb 25;55(2):285-294
Dual regulation of Akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis.
Xie Z, Xu J, Xiao D, Lei J, Yu J
Acta biochimica et biophysica Sinica 2023 Feb 25;55(1):62-71
Acta biochimica et biophysica Sinica 2023 Feb 25;55(1):62-71
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148
Cell death & disease 2023 Feb 21;14(2):148
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening.
Deng L, Yang L, Zhu S, Li M, Wang Y, Cao X, Wang Q, Guo L
Cell death discovery 2023 Feb 2;9(1):40
Cell death discovery 2023 Feb 2;9(1):40
Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis.
Zhao X, Chen Y, Zhang W, Zhang H, Hu Y, Yang F, Zhang Y, Song X
Veterinary sciences 2023 Feb 2;10(2)
Veterinary sciences 2023 Feb 2;10(2)
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia.
Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Flint TR, Connell CM, Lukey MJ, White EP, Coll AP, Venkitaraman AR, Janowitz T
bioRxiv : the preprint server for biology 2023 Feb 18;
bioRxiv : the preprint server for biology 2023 Feb 18;
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Tsai TH, Su YF, Tsai CY, Wu CH, Lee KT, Hsu YC
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain.
Ren X, Zhuang H, Li B, Jiang F, Zhang Y, Zhou P
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Yang CS, Guo XS, Yue YY, Wang Y, Jin XL
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: Novel perspectives on the mechanism underlying DEHP genotoxicity in male germ cells.
Fu H, Zhu X, Di Q, Sun J, Jiang Q, Xu Q
The Science of the total environment 2023 Feb 10;859(Pt 2):160432
The Science of the total environment 2023 Feb 10;859(Pt 2):160432
Piceatannol and 3'-Hydroxypterostilbene Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Lin WS, Chueh TL, Nagabhushanam K, Ho CT, Pan MH
Journal of agricultural and food chemistry 2023 Feb 1;71(4):1994-2005
Journal of agricultural and food chemistry 2023 Feb 1;71(4):1994-2005
Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.
Liu WC, Chiu HW, Chou CL, Chiu YJ, Lee YH
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871
Environmental pollution (Barking, Essex : 1987) 2023 Feb 1;318:120871
Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation.
Cheng XF, He ST, Zhong GQ, Meng JJ, Wang M, Bi Q, Tu RH
BMC cardiovascular disorders 2023 Feb 1;23(1):58
BMC cardiovascular disorders 2023 Feb 1;23(1):58
Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction.
Hao T, Ji G, Qian M, Li QX, Huang H, Deng S, Liu P, Deng W, Wei Y, He J, Wang S, Gao W, Li T, Cheng J, Tian J, Pan L, Gao F, Li Z, Zhao Q
Science advances 2023 Dec;9(48):eadi9967
Science advances 2023 Dec;9(48):eadi9967
Ursolic acid induces apoptosis and pyroptosis in Reh cells by upregulating of the JNK signalling pathway based on network pharmacology and experimental validation.
Luo Y, Xiang J, Tang S, Huang S, Zhou Y, Shen H
Heliyon 2023 Dec;9(12):e23079
Heliyon 2023 Dec;9(12):e23079
Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner.
Li J, Zhou L, Jiang Y, Gao H, Maierhaba T, Gong H
Molecular and cellular probes 2023 Dec;72:101937
Molecular and cellular probes 2023 Dec;72:101937
Simvastatin inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma through KLF2 signal.
Kou Y, Zhang Y, Rong X, Yang P, Wang C, Zhou Q, Liu H, Liu B, Li M
Journal of oral biosciences 2023 Dec;65(4):347-355
Journal of oral biosciences 2023 Dec;65(4):347-355
TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
Liu Z, Shang F, Li N, Dong W
In vitro cellular & developmental biology. Animal 2023 Dec;59(10):796-810
In vitro cellular & developmental biology. Animal 2023 Dec;59(10):796-810
Endonuclease G promotes preeclampsia by regulating the Wnt signaling pathway.
Yang J, Kou X
Autoimmunity 2023 Dec;56(1):2182741
Autoimmunity 2023 Dec;56(1):2182741
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells.
Huang J, Wei W, Kang F, Tan S, Li Y, Lu X, Wang N
Genes & genomics 2023 Dec;45(12):1575-1586
Genes & genomics 2023 Dec;45(12):1575-1586
CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis.
Kuang L, Lu A, Yao S
Renal failure 2023 Dec;45(1):2236219
Renal failure 2023 Dec;45(1):2236219
Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway.
Liu C, Cao Q, Chen Y, Chen X, Zhu Y, Zhang Z, Wei W
Journal of receptor and signal transduction research 2023 Dec;43(2):62-71
Journal of receptor and signal transduction research 2023 Dec;43(2):62-71
Effects and possible mechanisms of combined exposure to noise and carbon monoxide on male reproductive system in rats.
Li Y, Zhang Z, Wang J, Liu C, Liu Y, Jiang X, Chen Q, Ao L, Cao J, Sun L, Han F, Liu J
Environmental toxicology 2023 Dec;38(12):2926-2938
Environmental toxicology 2023 Dec;38(12):2926-2938
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Uqcr11 alleviates oxidative stress and apoptosis after traumatic brain injury.
Lin Y, Zhang J, Lu D, Zhang Y, Xu J, Wang S, Cheng X, Qin J, Zhang L, Li H, Zhang X, Li W
Experimental neurology 2023 Dec;370:114582
Experimental neurology 2023 Dec;370:114582
Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle.
Li QR, Xu HZ, Xiao RC, Liu B, Ma TQ, Yu TT, Li LG, Wang MF, Zhao L, Chen X, Li TF
Platelets 2023 Dec;34(1):2166677
Platelets 2023 Dec;34(1):2166677
BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway.
Xiao P, Chen X, Dong Z, Fan W, Chen Y, Su J, Wang Q, Ma L
Hematology (Amsterdam, Netherlands) 2023 Dec;28(1):2231739
Hematology (Amsterdam, Netherlands) 2023 Dec;28(1):2231739
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.
Wang T, Zhou Y, Bao H, Liu B, Wang M, Wang L, Pan T
Journal of cellular and molecular medicine 2023 Dec;27(23):3897-3910
Journal of cellular and molecular medicine 2023 Dec;27(23):3897-3910
Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).
Zhang H, Ran M, Jiang L, Sun X, Qiu T, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
Ecotoxicology and environmental safety 2023 Dec;268:115711
Ecotoxicology and environmental safety 2023 Dec;268:115711
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.
Peng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2023 Dec;268:115685
Ecotoxicology and environmental safety 2023 Dec;268:115685
Inhibition of S100A9 alleviates neurogenic pulmonary edema after subarachnoid hemorrhage.
Wang G, Hou G, Tian Q, Liu C, Guo Y, Wei H, Zhang Z, Li M
Biochemical pharmacology 2023 Dec;218:115905
Biochemical pharmacology 2023 Dec;218:115905
Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by enhancing necroptosis and apoptosis.
Hu S, Huang M, Mao S, Yang M, Ju H, Liu Z, Cheng M, Wu G
Biochemical pharmacology 2023 Dec;218:115903
Biochemical pharmacology 2023 Dec;218:115903
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Wang R, Li J, Fu Y, Li Y, Qi Y, Li C, Gao F, Li C
Biochemical pharmacology 2023 Dec;218:115874
Biochemical pharmacology 2023 Dec;218:115874
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Wang H, Yang G, Zhang X, Zhang H, Liu Y, Wang C, Miao L, Li Y, Huang Y, Teng H, Wang S, Cheng H, Zeng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Riboflavin protects against heart failure via SCAD-dependent DJ-1-Keap1-Nrf2 signalling pathway.
Xu Q, Cao Y, Zhong X, Qin X, Feng J, Peng H, Su Y, Ma Z, Zhou S
British journal of pharmacology 2023 Dec;180(23):3024-3044
British journal of pharmacology 2023 Dec;180(23):3024-3044
Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
Yan J, Xie J, Xu S, Guo Y, Ji K, Li C, Gao H, Zhao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737
Inhibiting NF-κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer.
Li W, Han F, Tang K, Ding C, Xiong F, Xiao Y, Li C, Liang Q, Lee KY, Lee IS, Gao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115725
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115725
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells.
Mao W, Wang Z, Wen S, Lin Y, Gu J, Sun J, Wang H, Cao Q, Xu Y, Xu X, Cai X
Virulence 2023 Dec;14(1):2287339
Virulence 2023 Dec;14(1):2287339
Eicosapentaenoic acid enhances the sensitivity of osteosarcoma to cisplatin by inducing ferroptosis through the DNA-PKcs/AKT/NRF2 pathway and reducing PD-L1 expression to attenuate immune evasion.
Zhang Y, Shen G, Meng T, Lv Z, Li X, Li J, Li K
International immunopharmacology 2023 Dec;125(Pt B):111181
International immunopharmacology 2023 Dec;125(Pt B):111181
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Meng T, Zhang D, Zhang Y, Tian P, Chen J, Liu A, Li Y, Song C, Zheng Y, Su G
International immunopharmacology 2023 Dec;125(Pt A):110978
International immunopharmacology 2023 Dec;125(Pt A):110978
Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway.
Hou X, Zhou C, Liang Z, Qiu H, Zhou Z, Zheng H, Li Z, Wang Y, Qi X, Lu L, Cao Y, Zheng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155093
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155093
Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis.
Bao S, Chen T, Chen J, Zhang J, Zhang G, Hui Y, Li J, Yan S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155078
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155078
Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer.
Wang J, Wang S, Wang J, Huang J, Lu H, Pan B, Pan H, Song Y, Deng Q, Jin X, Shi G
Cancer medicine 2023 Dec;12(24):22381-22394
Cancer medicine 2023 Dec;12(24):22381-22394
Umbelliferone attenuates cisplatin-induced acute kidney injury by inhibiting oxidative stress and inflammation via NRF2.
Yang Z, Ning R, Liu Q, Zang R, Liu S, Sun S
Physiological reports 2023 Dec;11(23):e15879
Physiological reports 2023 Dec;11(23):e15879
Probiotic-fermented Qushi decoction alleviates reserpine-induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
Zeng W, Chen Y, Zhang H, Peng L, Li Y, Liu B, Liang H, Du B, Li P
Journal of the science of food and agriculture 2023 Dec;103(15):7702-7711
Journal of the science of food and agriculture 2023 Dec;103(15):7702-7711
Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an Aβ 1-42 -induced Alzheimer's disease rat model by activating BDNF/TrkB signaling transduction.
Gu Z, Lv X, Guo Y, Qi M, Ge B
Neuroreport 2023 Dec 6;34(17):825-833
Neuroreport 2023 Dec 6;34(17):825-833
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Chen Y, He Z, Yang S, Chen C, Xiong W, He Y, Liu S
Journal of translational medicine 2023 Dec 6;21(1):886
Journal of translational medicine 2023 Dec 6;21(1):886
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Yi Y, Tianxin Y, Zhangchi L, Cui Z, Weiguo W, Bo Y
European journal of pharmacology 2023 Dec 5;960:176169
European journal of pharmacology 2023 Dec 5;960:176169
Cynanchum komarovii extract for the treatment of rheumatoid arthritis by acting on synovial cells in vitro and in vivo.
Hao F, Tao L, Liu J, Ma Y, Zhang J, Wang W, Yan W, Wang B, Wang X, Chen X, Ma Y, Fan H, Zhao X, Wang Z, Bai C
Journal of ethnopharmacology 2023 Dec 5;317:116825
Journal of ethnopharmacology 2023 Dec 5;317:116825
Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated m(6)A modification of SIRT3 mRNA.
Zhang Y, Wang R, Tan H, Wu K, Hu Y, Diao H, Wang D, Tang X, Leng M, Li X, Cai Z, Luo D, Shao X, Yan M, Chen Y, Rong X, Guo J
Journal of ethnopharmacology 2023 Dec 5;317:116766
Journal of ethnopharmacology 2023 Dec 5;317:116766
Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A.
Zhang J, Liu Y, An C, Liu C, Ma S, Zhang Q, Ding H, Shao J, Xue W
Foods (Basel, Switzerland) 2023 Dec 5;12(24)
Foods (Basel, Switzerland) 2023 Dec 5;12(24)
Choline induced cardiac dysfunction by inhibiting the production of endogenous hydrogen sulfide in spontaneously hypertensive rats.
Zhang W, Zhang Y, Xia Y, Feng G, Wang Y, Wei C, Tang A, Song K, Qiu R, Wu Y, Jin S
Physiological research 2023 Dec 31;72(6):719-730
Physiological research 2023 Dec 31;72(6):719-730
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Chen X, Fu K, Lai Y, Dong C, Chen Z, Huang Y, Li G, Jiang R, Wu H, Wang A, Huang S, Shen L, Gao W, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling.
Chen Y, Yin H, Sun J, Zhang G, Zhang Y, Zeng H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115822
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115822
Astragaloside IV enhances the sensitivity of breast cancer stem cells to paclitaxel by inhibiting stemness.
Huang P, Li H, Ren L, Xie H, Chen L, Liang Y, Hu Y, Selistre-de-Araujo HS, Boussios S, Jhawar SR, Cui R, Zuo Q, Chen Q
Translational cancer research 2023 Dec 31;12(12):3703-3717
Translational cancer research 2023 Dec 31;12(12):3703-3717
Ramelteon attenuates renal ischemia and reperfusion injury through reducing mitochondrial fission and fusion and inflammation.
Chen P, Liu W, Wei Y
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
Translational andrology and urology 2023 Dec 31;12(12):1859-1870
Canthaxanthin Attenuates the Vascular Aging or Endothelial Cell Senescence by Inhibiting Inflammation and Oxidative Stress in Mice.
Wang Z, Li L, Liao S, Huang R, Jiang Y, Fei J, Cai L, Zhang K
Frontiers in bioscience (Landmark edition) 2023 Dec 29;28(12):367
Frontiers in bioscience (Landmark edition) 2023 Dec 29;28(12):367
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Cheng J, Yan Z, Jiang K, Liu C, Xu D, Lyu X, Hu X, Zhang S, Zhou Y, Li J, Zhao Y
Journal of medicinal chemistry 2023 Dec 28;66(24):16991-17025
Journal of medicinal chemistry 2023 Dec 28;66(24):16991-17025
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.
Luo F, Tang Y, Zheng L, Yang Y, Gao H, Tian S, Chen H, Tang C, Tang S, Man Q, Wu Y
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy.
Zhang Q, Wang X, Zhao Y, Cheng Z, Fang D, Liu Y, Tian G, Li M, Luo Z
ACS nano 2023 Dec 26;17(24):25419-25438
ACS nano 2023 Dec 26;17(24):25419-25438
Mesenchymal stem cell exosomes inhibit nucleus pulposus cell apoptosis via the miR-125b-5p/TRAF6/NF-κB pathway axis.
Duan Y, Yu C, Kuang W, Li J, Qiu S, Ni S, Chen Z
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1938-1949
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1938-1949
Mitochondrion-targeted carboxymethyl chitosan hybrid nanoparticles loaded with Coenzyme Q10 protect cardiac grafts against cold ischaemia‒reperfusion injury in heart transplantation.
Yuan S, Che Y, Wang Z, Xing K, Xie X, Chen Y
Journal of translational medicine 2023 Dec 20;21(1):925
Journal of translational medicine 2023 Dec 20;21(1):925
Reactive Oxygen Species Damage Bovine Endometrial Epithelial Cells via the Cytochrome C-mPTP Pathway.
Song P, Sun M, Liu C, Liu J, Lin P, Chen H, Zhou D, Tang K, Wang A, Jin Y
Antioxidants (Basel, Switzerland) 2023 Dec 16;12(12)
Antioxidants (Basel, Switzerland) 2023 Dec 16;12(12)
PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer.
Wang C, Xu YH, Xu HZ, Li K, Zhang Q, Shi L, Zhao L, Chen X
Journal of nanobiotechnology 2023 Dec 11;21(1):476
Journal of nanobiotechnology 2023 Dec 11;21(1):476
TMEM44-AS1 promotes esophageal squamous cell carcinoma progression by regulating the IGF2BP2-GPX4 axis in modulating ferroptosis.
Yang R, Wan J, Ma L, Zhou F, Yang Z, Li Z, Zhang M, Ming L
Cell death discovery 2023 Dec 1;9(1):431
Cell death discovery 2023 Dec 1;9(1):431
Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathy.
Chen H, Liu Y, Zhang T, Huang T, Lang Y, Sheng Q, Liu Y, Kong Z, Gao Y, Lu S, Yang M, Li X, Wang R, Lv Z
Molecular and cellular endocrinology 2023 Dec 1;578:112065
Molecular and cellular endocrinology 2023 Dec 1;578:112065
Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway.
Li H, Chen Y, Ding M, Yan Z, Guo W, Guo R
Chemico-biological interactions 2023 Dec 1;386:110763
Chemico-biological interactions 2023 Dec 1;386:110763
Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer.
Geng P, Zhao J, Li Q, Wang X, Qin W, Wang T, Shi X, Liu X, Chen J, Qiu H, Xu G
International journal of molecular sciences 2023 Dec 1;24(23)
International journal of molecular sciences 2023 Dec 1;24(23)
Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats.
Wang Y, Liu Z, Ma G, Xu Y, Li Y
Tissue & cell 2023 Aug;83:102146
Tissue & cell 2023 Aug;83:102146
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Li P, Dai S, Gao X, Li W
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Natural killer cells strengthen antitumor activity of cisplatin by immunomodulation and ameliorate cisplatin-induced side effects.
Wang Z, Yang Z, Qu C, Li J, Wang X
International urology and nephrology 2023 Aug;55(8):1957-1970
International urology and nephrology 2023 Aug;55(8):1957-1970
hsa_circ_0000417 downregulation suppresses androgen receptor expression and apoptotic signals in human foreskin fibroblasts via sponging miR-6756-5p.
Huang J, Su C, Lu P, Zhao X, Liu Y, Xie Q, Chen C
Molecular biology reports 2023 Aug;50(8):6769-6781
Molecular biology reports 2023 Aug;50(8):6769-6781
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.
Gao J, Su G, Chen W, Wu Q, Liu J, Liu J, Chai M, Dong Y, Wang H, Chen L, Zhang Z, Wang M
Clinical and experimental pharmacology & physiology 2023 Aug;50(8):647-663
Clinical and experimental pharmacology & physiology 2023 Aug;50(8):647-663
The MyD88 inhibitor, ST2825, induces cell cycle arrest and apoptosis by suppressing the activation of the NF‑κB/AKT1/p21 pathway in pancreatic cancer.
Lu S, He T, Zhang Y, Zhou B, Zhang Q, Yan S
Oncology reports 2023 Aug;50(2)
Oncology reports 2023 Aug;50(2)
Effect of evernic acid on human breast cancer MCF-7 and MDA-MB-453 cell lines via thioredoxin reductase 1: A molecular approach.
Kalın ŞN, Altay A, Budak H
Journal of applied toxicology : JAT 2023 Aug;43(8):1148-1158
Journal of applied toxicology : JAT 2023 Aug;43(8):1148-1158
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway.
Chen Y, Zhang Y, Wang X, Qiao S
Journal of biochemical and molecular toxicology 2023 Aug;37(8):e23387
Journal of biochemical and molecular toxicology 2023 Aug;37(8):e23387
A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression.
Wen R, Zhang TN, Zhang T, Tong YJ, Song WL, Liu YP, Yang N, Liu CF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23063
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23063
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
He P, He Y, Ma J, Liu Y, Liu C, Baoping Y, Dong W
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
miR-101-5p overexpression suppresses the proliferation of goat spermatogonial stem cells by targeting EZH2.
Cai Y, Liu Z, Zhang G, Yang Y, Zhang Y, Wang F, Deng M
Animal reproduction science 2023 Aug;255:107281
Animal reproduction science 2023 Aug;255:107281
Role of Autophagy and Apoptosis in Aluminum Exposure-Induced Liver Injury in Rats.
Wei X, Li D, Luo Y, Wu B
Biological trace element research 2023 Aug;201(8):3971-3980
Biological trace element research 2023 Aug;201(8):3971-3980
Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.
Chen X, Song QL, Wang JY, Ji R, Li ZH, Cao ML, Mu XF, Guo DY, Zhang Y, Yang J
The American journal of pathology 2023 Aug;193(8):1059-1071
The American journal of pathology 2023 Aug;193(8):1059-1071
Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
Lu D, Wang Y, Liu G, Wang S, Duan A, Wang Z, Wang J, Sun X, Wu Y, Wang Z
Neurobiology of disease 2023 Aug;184:106228
Neurobiology of disease 2023 Aug;184:106228
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Yidian W, Jihe K, Xudong G, Daxue Z, Mingqiang L, Xuewen K
World neurosurgery 2023 Aug;176:e109-e124
World neurosurgery 2023 Aug;176:e109-e124
Immunosensitivity mediated by downregulated AKT1-SKP2 induces anti-PD-1-associated thyroid immune injury.
Wu Y, Li J, Yang X, Hou B, Qiao H
International immunopharmacology 2023 Aug;121:110452
International immunopharmacology 2023 Aug;121:110452
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Wan D, Zhu Z, Zhou J, Deng Z, Lei P, Liu Q, Sun X, Huang B
Toxicology research 2023 Aug;12(4):635-647
Toxicology research 2023 Aug;12(4):635-647
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer medicine 2023 Aug;12(15):16337-16358
Cancer medicine 2023 Aug;12(15):16337-16358
New murine model of alcoholic hepatitis in obesity-induced metabolic-associated fatty liver disease.
Cheng Y, Lin S, Ren T, Zhang J, Shi Y, Chen Y, Chen Y
Experimental animals 2023 Aug 7;72(3):389-401
Experimental animals 2023 Aug 7;72(3):389-401
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.
Li X, Sung P, Zhang D, Yan L
Physiological research 2023 Aug 31;72(4):497-510
Physiological research 2023 Aug 31;72(4):497-510
Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway.
Chang R, Jia H, Dong Z, Xu Q, Liu L, Majigsuren Z, Batbaatar T, Xu C, Yang Q, Sun X
Journal of agricultural and food chemistry 2023 Aug 30;71(34):12645-12656
Journal of agricultural and food chemistry 2023 Aug 30;71(34):12645-12656
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
Zhang X, Xiao Y, Huang Q
International journal of biological macromolecules 2023 Aug 30;247:125747
International journal of biological macromolecules 2023 Aug 30;247:125747
PHF23 promotes NSCLC proliferation, metastasis, and chemoresistance via stabilization of ACTN4 and activation of the ERK pathway.
Cheng M, Cao H, Yao P, Guan J, Wu P, Ji H, Jiang S, Yuan Y, Fu L, Zheng Q, Li Q
Cell death & disease 2023 Aug 25;14(8):558
Cell death & disease 2023 Aug 25;14(8):558
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
Hou B, Li D, Wang D, Jiang C, Wang G, Wang D, Yan G, Guo X, Zhao L, Wan Z, Fan C, Cao W, Ren H
Neuroscience 2023 Aug 21;526:74-84
Neuroscience 2023 Aug 21;526:74-84
NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis.
Wang H, Zhao P, Zhang Y, Chen Z, Bao H, Qian W, Wu J, Xing Z, Hu X, Jin K, Zhuge Q, Yang J
Cell death discovery 2023 Aug 15;9(1):297
Cell death discovery 2023 Aug 15;9(1):297
Silibinin exerts neuroprotective effects against cerebral hypoxia/reoxygenation injury by activating the GAS6/Axl pathway.
Li W, Zhang Z, Li J, Mu J, Sun M, Wu X, Niu X, Yang Y, Yan H, Xu X, Xue C, Qian L, Tian Y
Toxicology 2023 Aug 15;495:153598
Toxicology 2023 Aug 15;495:153598
Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer.
Liu Z, Ke S, Wang Q, Gu X, Zhai G, Shao H, He M, Guo J
Experimental cell research 2023 Aug 15;429(2):113686
Experimental cell research 2023 Aug 15;429(2):113686
ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
Jia Y, Huang X, Shi H, Wang M, Chen J, Zhang H, Hou D, Jing H, Du J, Han H, Zhang J
Experimental cell research 2023 Aug 15;429(2):113629
Experimental cell research 2023 Aug 15;429(2):113629
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Zhang X, Liu T, Hou X, Zhou Z, Zhang F, Ma H, Wu X, Jiang J
Scientific reports 2023 Aug 14;13(1):13213
Scientific reports 2023 Aug 14;13(1):13213
Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest.
Yan T, Yang H, Xu C, Liu J, Meng Y, Jiang Q, Li J, Kang G, Zhou L, Xiao S, Xue Y, Xu J, Chen X, Che F
Cancer cell international 2023 Aug 11;23(1):163
Cancer cell international 2023 Aug 11;23(1):163
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Tang H, Zheng Z, Wang H, Wang L, Zhao G, Wang P
Nutrients 2023 Aug 11;15(16)
Nutrients 2023 Aug 11;15(16)
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.
Zhou M, Gao Y, Wu S, Chen J, Ding J, Wang Y, Yang J
Biology of reproduction 2023 Aug 10;109(2):204-214
Biology of reproduction 2023 Aug 10;109(2):204-214
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Jiang C, Shen J, Wang C, Huang Y, Wang L, Yang Y, Hu W, Li P, Wu H
Toxicology letters 2023 Aug 1;384:86-95
Toxicology letters 2023 Aug 1;384:86-95
LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway.
Bai Y, Hei N, Gao M, Dong X, Li M, Jiang S, Zhang L
Toxicology letters 2023 Aug 1;384:30-43
Toxicology letters 2023 Aug 1;384:30-43
SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro.
Du P, Liu T, Luo P, Li H, Tang W, Zong S, Xiao H
Archives of toxicology 2023 Apr;97(4):1147-1162
Archives of toxicology 2023 Apr;97(4):1147-1162
LncRNA-PEAK1 promotes neuronal apoptosis after intracerebral hemorrhage by miR-466i-5p/caspase 8 axis.
Chen JX, Zhi JW, Wang YP, Ning B
Heliyon 2023 Apr;9(4):e15091
Heliyon 2023 Apr;9(4):e15091
Mitochondrial division inhibitor (mdivi-1) inhibits proliferation and epithelial-mesenchymal transition via the NF-κB pathway in thyroid cancer cells.
Zhang L, Sun L, Wang L, Wang J, Wang D, Jiang J, Zhang J, Zhou Q
Toxicology in vitro : an international journal published in association with BIBRA 2023 Apr;88:105552
Toxicology in vitro : an international journal published in association with BIBRA 2023 Apr;88:105552
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
Long F, Hu L, Chen Y, Duan X, Xie K, Feng J, Wang M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Apr;72(4):731-744
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Apr;72(4):731-744
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia.
Wang Y, Wang D, Wang Y, Yang H, Wang G, Wu S
Neoplasma 2023 Apr;70(2):287-293
Neoplasma 2023 Apr;70(2):287-293
High expression of centromere protein N as novel biomarkers for gastric adenocarcinoma.
Wang X, Zhang K, Fu C, Wu F, Zhang J, Han B, Pan H, Luan L
Cancer reports (Hoboken, N.J.) 2023 Apr;6(4):e1798
Cancer reports (Hoboken, N.J.) 2023 Apr;6(4):e1798
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy.
Li L, Song JJ, Zhang MX, Zhang HW, Zhu HY, Guo W, Pan CL, Liu X, Xu L, Zhang ZY
Acta pharmacologica Sinica 2023 Apr;44(4):726-740
Acta pharmacologica Sinica 2023 Apr;44(4):726-740
Inhibition of autophagic flux by the curcumin analog EF-24 and its antiproliferative effect on MCF-7 cancer cells.
Li J, Wang SH, Liu YT, Zhang Q, Zhou GZ
Journal of biochemical and molecular toxicology 2023 Apr;37(4):e23307
Journal of biochemical and molecular toxicology 2023 Apr;37(4):e23307
Perilla frutescens L. alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation.
Yong C, Huang G, Ge H, Zhu Y, Yang Y, Yu Y, Tian F, Gao K, Zhou E
Phytotherapy research : PTR 2023 Apr;37(4):1274-1292
Phytotherapy research : PTR 2023 Apr;37(4):1274-1292
The effect of regulating MCU expression on experimental ischemic brain injury.
Qin J, Liu L, Liu L, Zhou Z, Zhou Y, Zhang K, Wang B, Lu H, Ran J, Ma T, Zhang Y, Li Z, Liu X
Experimental neurology 2023 Apr;362:114329
Experimental neurology 2023 Apr;362:114329
Decreased autophagic activity of detrusor cells is involved in the inflammatory response of interstitial cystitis/bladder pain syndrome.
Zhao J, Lu Q, Yang Z, Sun B, Zhu J, Zhang H, Yang C, Yi S, Dong X
International urogynecology journal 2023 Apr;34(4):843-851
International urogynecology journal 2023 Apr;34(4):843-851
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Liang Z, Yang Y, Wu X, Lu C, Zhao H, Chen K, Zhao A, Li X, Xu J
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Angiotensin-(1-9) prevents angiotensin II-induced endothelial apoptosis through CNPY2/PERK pathway.
Guo CL, Liu HM, Li B, Lu ZY
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):379-396
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):379-396
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Qian X, Xiong S, Chen Q, Zhang J, Xie J
Experimental and therapeutic medicine 2023 Apr;25(4):150
Experimental and therapeutic medicine 2023 Apr;25(4):150
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Zhang L, Xue K, Fan P, Chen C, Hu J, Huang J, Lu W, Xu J, Xu S, Ran J, Zhu S, Gan S
Experimental eye research 2023 Apr;229:109416
Experimental eye research 2023 Apr;229:109416
Apolipoprotein E2 inhibits mitochondrial apoptosis in pancreatic cancer cells through ERK1/2/CREB/BCL-2 signaling.
Wang H, Zhou HC, Ren RL, Du SX, Guo ZK, Shen XH
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Apr;22(2):179-189
Hydrogen sulfide regulates SERCA2a SUMOylation by S-Sulfhydration of SENP1 to ameliorate cardiac systole-diastole function in diabetic cardiomyopathy.
Peng S, Wang M, Zhang S, Liu N, Li Q, Kang J, Chen L, Li M, Pang K, Huang J, Lu F, Zhao D, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114200
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114200
Roles of TRPV4 in Regulating Circulating Angiogenic Cells to Promote Coronary Microvascular Regeneration.
Yang W, Wang H, Guo Q, Xu X, Guo T, Sun L
Journal of cardiovascular translational research 2023 Apr;16(2):414-426
Journal of cardiovascular translational research 2023 Apr;16(2):414-426
Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway.
Zhao H, Lv J, Meng L, Lv J, Li Z
International immunopharmacology 2023 Apr;117:109980
International immunopharmacology 2023 Apr;117:109980
Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy.
Han N, Yang ZY, Xie ZX, Xu HZ, Yu TT, Li QR, Li LG, Peng XC, Yang XX, Hu J, Xu X, Chen X, Wang MF, Li TF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154682
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Apr;112:154682
Knockdown of KDM5B Leads to DNA Damage and Cell Cycle Arrest in Granulosa Cells via MTF1.
Yang Y, Cai Y, Guo J, Dai K, Liu L, Chen Z, Wang F, Deng M
Current issues in molecular biology 2023 Apr 7;45(4):3219-3237
Current issues in molecular biology 2023 Apr 7;45(4):3219-3237
Astragalus polysaccharide attenuates bleomycin-induced pulmonary fibrosis by inhibiting TLR4/ NF-κB signaling pathway and regulating gut microbiota.
Wei Y, Qi M, Liu C, Li L
European journal of pharmacology 2023 Apr 5;944:175594
European journal of pharmacology 2023 Apr 5;944:175594
Potential Effect of Glutamine in the Improvement of Intestinal Stem Cell Proliferation and the Alleviation of Burn-Induced Intestinal Injury via Activating YAP: A Preliminary Study.
Chen X, Zhang P, Zhang Y, Fan S, Wei Y, Yang Z, Wang F, Peng X
Nutrients 2023 Apr 4;15(7)
Nutrients 2023 Apr 4;15(7)
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Zhong Y, Wang L, Jin R, Liu J, Luo R, Zhang Y, Zhu L, Peng X
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer.
Yang H, Pu L, Li R, Zhu R
Journal of gastrointestinal oncology 2023 Apr 29;14(2):900-912
Journal of gastrointestinal oncology 2023 Apr 29;14(2):900-912
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
[Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway].
Wu J, Deng Z, Zhu Y, Dou G, Li J, Huang L
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):537-543
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):537-543
[High expression of MYH9 inhibits apoptosis of non-small cell lung cancer cells through activating the AKT/c-Myc pathway].
Liu F, Peng L, Xi J
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):527-536
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):527-536
The emerging role of lysine succinylation in ovarian aging.
Le M, Li J, Zhang D, Yuan Y, Zhou C, He J, Huang J, Hu L, Luo T, Zheng L
Reproductive biology and endocrinology : RB&E 2023 Apr 20;21(1):38
Reproductive biology and endocrinology : RB&E 2023 Apr 20;21(1):38
Antioxidant, Immunostimulatory, and Anticancer Properties of Hydrolyzed Wheat Bran Mediated through Macrophages Stimulation.
Tomé-Sánchez I, Martínez-Villaluenga C, Martín-Diana AB, Rico D, Jiménez-Pulido I, Frias J, Dia VP
International journal of molecular sciences 2023 Apr 18;24(8)
International journal of molecular sciences 2023 Apr 18;24(8)
AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.
Huang YK, Chang KC, Li CY, Lieu AS, Lin CL
Current issues in molecular biology 2023 Apr 13;45(4):3391-3405
Current issues in molecular biology 2023 Apr 13;45(4):3391-3405
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.
Yu J, Liu T, Guo Q, Wang Z, Chen Y, Dong Y
Microbiology spectrum 2023 Apr 13;11(2):e0469822
Microbiology spectrum 2023 Apr 13;11(2):e0469822
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer.
Wang K, Li Q, Fan Y, Fang P, Zhou H, Huang J
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
Li TY, Du Y, Wang MC, Liu K, Liu Y, Cao Y, Wang YY, Chen WW, Qian XY, Qiu PC, Tang HF, Lu YY
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway.
Feng Z, Wang T, Sun Y, Chen S, Hao H, Du W, Zou H, Yu D, Zhu H, Pang Y
Ecotoxicology and environmental safety 2023 Apr 1;254:114747
Ecotoxicology and environmental safety 2023 Apr 1;254:114747
Renal Ischemia-reperfusion Injury Attenuated by Exosomes Extracted From Splenic Ischemic Preconditioning Models.
Liu H, Shen Y
Transplantation 2023 Apr 1;107(4):e90-e97
Transplantation 2023 Apr 1;107(4):e90-e97
The preventive and therapeutic effect of repetitive transcranial magnetic stimulation on radiation-induced brain injury in mice.
Liu LY, Qin TZ, Guo L, Rong-Rong H, Jing YT, Lai PP, Xue YZ, Ding GR
International journal of radiation biology 2022;98(8):1316-1329
International journal of radiation biology 2022;98(8):1316-1329
Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.
Luo M, Cao S, Lv D, He L, He Z, Li L, Li Y, Luo S, Chang Q
Frontiers in cardiovascular medicine 2022;9:922705
Frontiers in cardiovascular medicine 2022;9:922705
Isoliquiritin Ameliorates Cisplatin-Induced Renal Proximal Tubular Cell Injury by Antagonizing Apoptosis, Oxidative Stress and Inflammation.
Pei Z, Wu M, Yu H, Long G, Gui Z, Li X, Chen H, Jia Z, Xia W
Frontiers in medicine 2022;9:873739
Frontiers in medicine 2022;9:873739
The Selenium Yeast vs Selenium Methionine on Cell Viability, Selenoprotein Profile and Redox Status via JNK/ P38 Pathway in Porcine Mammary Epithelial Cells.
Wu C, Cui C, Zheng X, Wang J, Ma Z, Zhu P, Lin G, Zhang S, Guan W, Chen F
Frontiers in veterinary science 2022;9:850935
Frontiers in veterinary science 2022;9:850935
6-Shogaol Inhibits Oxidative Stress-Induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 Axis.
Liu J, Li B, Li W, Pan T, Diao Y, Wang F
Frontiers in molecular biosciences 2022;9:808162
Frontiers in molecular biosciences 2022;9:808162
Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy.
Song H, Chen S, Zhang T, Huang X, Zhang Q, Li C, Chen C, Chen S, Liu D, Wang J, Tu Y, Wu Y, Liu Y
Frontiers in molecular biosciences 2022;9:805235
Frontiers in molecular biosciences 2022;9:805235
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
Wang X, Yu S, Jian Y, Pan H, Guo J, Wu J, Guo W
Frontiers in cardiovascular medicine 2022;9:1023982
Frontiers in cardiovascular medicine 2022;9:1023982
TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling.
Wang X, Fu Y, Xing Y
Clinics (Sao Paulo, Brazil) 2022;77:100122
Clinics (Sao Paulo, Brazil) 2022;77:100122
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Cui L, Li Z, Xu F, Tian Y, Chen T, Li J, Guo Y, Lyu Q
Nutrition and cancer 2022;74(4):1399-1410
Nutrition and cancer 2022;74(4):1399-1410
Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.
Zeng Q, Singh R, Ye Y, Cheng S, Fan C, Zeng Q
Nutrition and cancer 2022;74(3):1058-1070
Nutrition and cancer 2022;74(3):1058-1070
MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B.
Yan W, Feng Y, Lei Z, Kuang W, Long C
Folia biologica 2022;68(2):78-85
Folia biologica 2022;68(2):78-85
MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway.
Shen X, Tao J, Wang Z, Li G, Zhang Z, Li J, Diliar A
International heart journal 2022;63(5):881-892
International heart journal 2022;63(5):881-892
LincRNA-p21 Upregulates Nuclear Orphan Receptor Nr4a2 and Aggravates Myocardial Ischemia/Reperfusion Injury via Targeting MiR-466i-5p.
Zhai X, Liu R, Li J, Wang F, Liu L, Wei S, Bian Y, Pang J, Xue M, Qin D, Wang S, Xu T, Xu F, Cao S, Yuan Q, Chen Y
International heart journal 2022;63(5):1004-1014
International heart journal 2022;63(5):1004-1014
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Xiong W, Huang XL, Li CY, Wang XL, Lan HW, Wang TT, Chen ZL, Yang QP, Hu AL, Xia YF, Zhu FR, Zhou ZZ
Folia histochemica et cytobiologica 2022;60(4):323-334
Folia histochemica et cytobiologica 2022;60(4):323-334
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Wang Y, Chen M, Gao Y, He K, Yang Z, Li Y, Zhang S, Zhao L
Acta cirurgica brasileira 2022;37(8):e370805
Acta cirurgica brasileira 2022;37(8):e370805
Mechanism of HSP90 Inhibitor in the Treatment of DSS-induced Colitis in Mice by Inhibiting MAPK Pathway and Synergistic Effect of Compound Sophorae Decoction.
Yuan Y, Wu H, Shuai B, Liu C, Zhu F, Gao F, Wei C, Fan H
Current pharmaceutical design 2022;28(42):3456-3468
Current pharmaceutical design 2022;28(42):3456-3468
IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.
Bai Y, Wu H, Zhang J, Zhang S, Zhang Z, Wang H, Zhang Y, Shen Z
Oxidative medicine and cellular longevity 2022;2022:9635075
Oxidative medicine and cellular longevity 2022;2022:9635075
A Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer.
Ding P, Guo Y, Wang C, Chen J, Guo C, Liu H, Shi Q
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9364313
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9364313
Bixin Prevents Colorectal Cancer Development through AMPK-Activated Endoplasmic Reticulum Stress.
Qiu Y, Li C, Zhang B
BioMed research international 2022;2022:9329151
BioMed research international 2022;2022:9329151
MTMR14 Alleviates Chronic Obstructive Pulmonary Disease as a Regulator in Inflammation and Emphysema.
Gu Y, Chen J, Huang Q, Zhan Y, Wang T, Wu J, Zhao J, Zeng Z, Lv Y, Xiao C, Xie J
Oxidative medicine and cellular longevity 2022;2022:9300269
Oxidative medicine and cellular longevity 2022;2022:9300269
Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.
Zha Z, Liu YJ, Liu SS, Zhang N, Li JL, Qi F, Jin LY, Xue B, Yang T, Fan YP, Zhao H, Wang L
Mediators of inflammation 2022;2022:9241261
Mediators of inflammation 2022;2022:9241261
PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.
Zhang X, Sun M, Jiao Y, Lin B, Yang Q
Oxidative medicine and cellular longevity 2022;2022:9029544
Oxidative medicine and cellular longevity 2022;2022:9029544
Development of a Costimulatory Molecule Signature to Predict Prognosis, Immune Landscape, and Response to Immune Therapy for Hepatocellular Carcinoma.
Zhou Y, Zhou X, Liu Q, Zhang Z, Zhang W, Ma J, Yang M, Yu J, Luo J, Yan Z
Disease markers 2022;2022:8973721
Disease markers 2022;2022:8973721
Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice.
Yang CJ, Li X, Feng XQ, Chen Y, Feng JG, Jia J, Wei JC, Zhou J
Oxidative medicine and cellular longevity 2022;2022:8729398
Oxidative medicine and cellular longevity 2022;2022:8729398
Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.
Jiang QY, Li JM, Jing MR, Zhang YX, Zhang QQ, Cai CB, Wang D, Qi HW, Li T, Li YZ, Ji XY, Wu DD
Oxidative medicine and cellular longevity 2022;2022:8678363
Oxidative medicine and cellular longevity 2022;2022:8678363
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Ma H, Duan X, Zhang R, Li H, Guo Y, Tian Y, Huang M, Chen G, Wang Z, Li L
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Gao Y, Hu M, Niu X, Li M, Xu L, Xiao Y, Zhang J, Wang H, Li L, Chu B, Lv P
Oxidative medicine and cellular longevity 2022;2022:8652741
Oxidative medicine and cellular longevity 2022;2022:8652741
Resveratrol Induces Apoptosis, Suppresses Migration, and Invasion of Cervical Cancer Cells by Inhibiting the Hedgehog Signaling Pathway.
Jiang J, Liu Z, Zhou X, Peng F, Wang Z, Li F, Li M
BioMed research international 2022;2022:8453011
BioMed research international 2022;2022:8453011
Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells.
Song D, Liu F, Tao W, Wu X, Bi H, Li X, Shu J, Wang D
Oxidative medicine and cellular longevity 2022;2022:8359118
Oxidative medicine and cellular longevity 2022;2022:8359118
Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis.
Luo M, Hu Y, Lv D, Xie L, Yang S, Zuo D, Xue Y, He A
Oxidative medicine and cellular longevity 2022;2022:7812407
Oxidative medicine and cellular longevity 2022;2022:7812407
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Wang P, Zhang S, Liu W, Chen S, Lv X, Hu B, Shao Z
Oxidative medicine and cellular longevity 2022;2022:7531788
Oxidative medicine and cellular longevity 2022;2022:7531788
Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK.
Chen C, Chen Y, Liu T, Song D, Ma D, Cheng O
Oxidative medicine and cellular longevity 2022;2022:7511393
Oxidative medicine and cellular longevity 2022;2022:7511393
Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer.
Feng Y, Wang X, Huang C, Zhang D, Liu T, Zhang C, Zhang Y, Ji D, Tang J, Sun Y
Oxidative medicine and cellular longevity 2022;2022:7242124
Oxidative medicine and cellular longevity 2022;2022:7242124
EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress.
Wu W, Gou H, Xiang B, Geng R, Dong J, Yang X, Chen D, Dai R, Chen L, Liu J
Journal of oncology 2022;2022:7099589
Journal of oncology 2022;2022:7099589
Xiaotan Sanjie Decoction Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion through lncRNA-ATB and miR-200A.
Zhou Z, Chen J, Li M, Cao L, Chen M, Zhang Q, Yu Z, Chai K
BioMed research international 2022;2022:7029182
BioMed research international 2022;2022:7029182
Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo.
Li Y, Shi D, Zhang H, Yao X, Ren K
Analytical cellular pathology (Amsterdam) 2022;2022:6984200
Analytical cellular pathology (Amsterdam) 2022;2022:6984200
Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora.
Zhan L, Liu H, Zheng J, Meng J, Fu D, Pang L, Ji C
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6706622
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6706622
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Chen A, Xu M, Chen J, Chen T, Wang Q, Zhang R, Qiu J
BioMed research international 2022;2022:6207701
BioMed research international 2022;2022:6207701
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.
Zhang YL, Li PB, Han X, Zhang B, Li HH
Oxidative medicine and cellular longevity 2022;2022:6196173
Oxidative medicine and cellular longevity 2022;2022:6196173
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.
Mu L, Chen N, Chen Y, Yang Z, Zhou H, Song S, Shi Y
International journal of endocrinology 2022;2022:6073911
International journal of endocrinology 2022;2022:6073911
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X
Oxidative medicine and cellular longevity 2022;2022:5992436
Oxidative medicine and cellular longevity 2022;2022:5992436
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Pang W, Lu S, Zheng R, Li X, Yang S, Feng Y, Wang S, Guo J, Zhou S
BioMed research international 2022;2022:5940372
BioMed research international 2022;2022:5940372
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway.
Wang M, Zhang Q, Li Y, Jin L, Fang Z
Journal of oncology 2022;2022:5824617
Journal of oncology 2022;2022:5824617
Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis.
Yang W, Wang Y, Zhang P, Wang T, Li C, Tong X, Zeng X, Yin Y, Tao K, Li R
Mediators of inflammation 2022;2022:5766434
Mediators of inflammation 2022;2022:5766434
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
Shi H, Yan Y, Yang H, Pu P, Tang H
BioMed research international 2022;2022:5623555
BioMed research international 2022;2022:5623555
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
Feng S, Wan S, Liu S, Wang W, Tang M, Bai L, Zhu Y
Oxidative medicine and cellular longevity 2022;2022:5501346
Oxidative medicine and cellular longevity 2022;2022:5501346
CORM-3 Attenuates Oxidative Stress-Induced Bone Loss via the Nrf2/HO-1 Pathway.
Jin C, Lin BH, Zheng G, Tan K, Liu GY, Yao Z, Xie J, Chen WK, Chen L, Xu TH, Huang CB, Wu ZY, Yang L
Oxidative medicine and cellular longevity 2022;2022:5098358
Oxidative medicine and cellular longevity 2022;2022:5098358
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Lei Y, Chan M, Liu H, Lyu W, Chen L, Zhong Y, Gan H, Wang M, Qi M, Guo Y, Liu J, Zhang E
Disease markers 2022;2022:4399334
Disease markers 2022;2022:4399334
Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m(6)A Modification of MAT2A Pre-mRNA by METTL16.
Chen PB, Shi GX, Liu T, Li B, Jiang SD, Zheng XF, Jiang LS
Oxidative medicine and cellular longevity 2022;2022:4036274
Oxidative medicine and cellular longevity 2022;2022:4036274
The lncRNA KIF9-AS1 Accelerates Hepatocellular Carcinoma Growth by Recruiting DNMT1 to Promote RAI2 DNA Methylation.
Yu Y, Lu X, Yan Y, Wang Y, Meng J, Tian S, Mu J
Journal of oncology 2022;2022:3888798
Journal of oncology 2022;2022:3888798
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury.
Liu WZ, Ma ZJ, Kang JH, Lin AX, Wang ZH, Chen HW, Guo XD, He XG, Kang XW
Mediators of inflammation 2022;2022:2579003
Mediators of inflammation 2022;2022:2579003
SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis.
Zhou X, Lin L, Qi Y, Xu M, Xu Q, Wang Y, Qu J
Disease markers 2022;2022:2562595
Disease markers 2022;2022:2562595
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Chen X, Yang G, Guo X, Zhang J, Sun W, Liu D, Wang H, Liu S
Oxidative medicine and cellular longevity 2022;2022:2543220
Oxidative medicine and cellular longevity 2022;2022:2543220
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2502263
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Qi S, Yan Q, Wang Z, Liu D, Zhan M, Du J, Chen L
PPAR research 2022;2022:2212996
PPAR research 2022;2022:2212996
Curcumin Inhibits Hyperandrogen-Induced IRE1α-XBP1 Pathway Activation by Activating the PI3K/AKT Signaling in Ovarian Granulosa Cells of PCOS Model Rats.
Zhang Y, Wang L, Weng Y, Wang D, Wang R, Wang H, Wang L, Shen S, Wang H, Li Y, Wang Y
Oxidative medicine and cellular longevity 2022;2022:2113293
Oxidative medicine and cellular longevity 2022;2022:2113293
Propofol Upregulates MicroRNA-30b to Inhibit Excessive Autophagy and Apoptosis and Attenuates Ischemia/Reperfusion Injury In Vitro and in Patients.
Lu Z, Shen J, Chen X, Ruan Z, Cai W, Cai S, Li M, Yang Y, Mo J, Mo G, Lu Y, Tang J, Zhang L
Oxidative medicine and cellular longevity 2022;2022:2109891
Oxidative medicine and cellular longevity 2022;2022:2109891
Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells.
Hu H, Luo Z, Liu X, Huang L, Lu X, Ding R, Duan C, He Y
International journal of endocrinology 2022;2022:2009753
International journal of endocrinology 2022;2022:2009753
Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway.
Wang G, Ma L, Wang B, Gao F, Li J, Cai H, Wang J, Zhang T, Guo H, Xie P, Li Y
Mediators of inflammation 2022;2022:1478181
Mediators of inflammation 2022;2022:1478181
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Mao Y, Du J, Chen X, Al Mamun A, Cao L, Yang Y, Mubwandarikwa J, Zaeem M, Zhang W, Chen Y, Dai Y, Xiao J, Ye K
Oxidative medicine and cellular longevity 2022;2022:1337630
Oxidative medicine and cellular longevity 2022;2022:1337630
Protective Effects of Vitamin C against Neomycin-Induced Apoptosis in HEI-OC1 Auditory Cell.
Gong L, Chen B, Chen J, Li Y
Neural plasticity 2022;2022:1298692
Neural plasticity 2022;2022:1298692
Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1.
Cai J, Wang X, Liao W, Zhong Y, Chen L, Zhang Z
BioMed research international 2022;2022:1138709
BioMed research international 2022;2022:1138709
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.
Jia C, Li X, Pan J, Ma H, Wu D, Lu H, Wang W, Zhang X, Yi X
Oxidative medicine and cellular longevity 2022;2022:1135827
Oxidative medicine and cellular longevity 2022;2022:1135827
Novel Application of Eupatilin for Effectively Attenuating Cisplatin-Induced Auditory Hair Cell Death via Mitochondrial Apoptosis Pathway.
Lu X, Deng T, Dong H, Han J, Yu Y, Xiang D, Nie G, Hu B
Oxidative medicine and cellular longevity 2022;2022:1090034
Oxidative medicine and cellular longevity 2022;2022:1090034
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Chen YG, Liu HX, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY, Wu DD, Ji XY
International journal of biological sciences 2022;18(9):3605-3620
International journal of biological sciences 2022;18(9):3605-3620
Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction.
Gou W, Luo N, Yu B, Wu H, Wu S, Tian C, Guo J, Ning H, Bi C, Wei H, Hou W, Li Y
International journal of biological sciences 2022;18(6):2639-2651
International journal of biological sciences 2022;18(6):2639-2651
Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.
Yu HF, Yang ZQ, Xu MY, Huang JC, Yue ZP, Guo B
International journal of biological sciences 2022;18(6):2261-2276
International journal of biological sciences 2022;18(6):2261-2276
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Huang JC, Duan CC, Jin S, Sheng CB, Wang YS, Yue ZP, Guo B
International journal of biological sciences 2022;18(5):2047-2059
International journal of biological sciences 2022;18(5):2047-2059
Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
Zhang Q, Luo P, Chen J, Yang C, Xia F, Zhang J, Tang H, Liu D, Gu L, Shi Q, He X, Yang T, Wang J
International journal of biological sciences 2022;18(5):2003-2017
International journal of biological sciences 2022;18(5):2003-2017
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.
Dou Z, Qiu C, Zhang X, Yao S, Zhao C, Wang Z, Chu R, Chen J, Chen Z, Li R, Wang K, Liu P, Liu C, Song K, Kong B
International journal of biological sciences 2022;18(3):1188-1210
International journal of biological sciences 2022;18(3):1188-1210
Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.
Liu F, Huang J, Zhang C, Xie Y, Cao Y, Tao L, Tang H, Lin J, Hammes HP, Huang K, Yi F, Su H, Zhang C
International journal of biological sciences 2022;18(15):5624-5640
International journal of biological sciences 2022;18(15):5624-5640
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
Wu X, Wei S, Chen M, Li J, Wei Y, Zhang J, Dong W
International journal of biological sciences 2022;18(13):5056-5069
International journal of biological sciences 2022;18(13):5056-5069
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Zhang C, Pan R, Ma S, Xu S, Wang B
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Targeted Nanobubbles of PD-L1 mAb Combined with Doxorubicin as a Synergistic Tumor Repressor in Hepatocarcinoma.
Chen Y, Luo X, Liu Y, Zou Y, Yang S, Liu C, Zhao Y
International journal of nanomedicine 2022;17:3989-4008
International journal of nanomedicine 2022;17:3989-4008
Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.
Liu C, Gao R, Tang Y, Chen H, Zhang X, Sun Y, Zhao Q, Lv P, Wang H, Ye-Lehmann S, Liu J, Chen C
Frontiers in neuroscience 2022;16:925300
Frontiers in neuroscience 2022;16:925300
Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy.
Wang Z, Zhang D, Yi XZ, Zhao Y, Yu A
Frontiers in neuroscience 2022;16:914344
Frontiers in neuroscience 2022;16:914344
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Xiao S, Zhou Y, Wang Q, Yang D
Drug design, development and therapy 2022;16:4411-4428
Drug design, development and therapy 2022;16:4411-4428
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Hu H, Mao G, Zheng J, Guo F
Drug design, development and therapy 2022;16:4223-4234
Drug design, development and therapy 2022;16:4223-4234
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H
Drug design, development and therapy 2022;16:279-296
Drug design, development and therapy 2022;16:279-296
Expression and potential role of FOSB in glioma.
Qi M, Sun LA, Zheng LR, Zhang J, Han YL, Wu F, Zhao J, Niu WH, Fei MX, Jiang XC, Zhou ML
Frontiers in molecular neuroscience 2022;15:972615
Frontiers in molecular neuroscience 2022;15:972615
The Ameliorative Effect of JNK Inhibitor D-JNKI-1 on Neomycin-Induced Apoptosis in HEI-OC1 Cells.
Zhao J, Liu H, Huang Z, Yang R, Gong L
Frontiers in molecular neuroscience 2022;15:824762
Frontiers in molecular neuroscience 2022;15:824762
Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways.
Li B, Yang X, Zhang P, Guo J, Rong K, Wang X, Cao X, Zhou T, Zhao J
Journal of inflammation research 2022;15:5767-5783
Journal of inflammation research 2022;15:5767-5783
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Luo J, Li L, Chang B, Zhu Z, Deng F, Hu M, Yu Y, Lu X, Chen Z, Zuo D, Zhou J
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
CSTF2 Acts as a Prognostic Marker Correlated with Immune Infiltration in Hepatocellular Carcinoma.
Zhang W, Wan Y, Zhang Y, Liu Q, Zhu X
Cancer management and research 2022;14:2691-2709
Cancer management and research 2022;14:2691-2709
BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53.
Luo Y, Wang X, Niu W, Zhou Y, Li M, Ma J, Yang J, Fan S, Zeng Z, Xiong W, Li X, Li G, Xiao J, Zhou M
Journal of Cancer 2022;13(5):1436-1448
Journal of Cancer 2022;13(5):1436-1448
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Liu M, Hu T, Gou W, Chang H, Li Y, Li Y, Zuo D, Hou W, Jiao S
Frontiers in pharmacology 2022;13:993022
Frontiers in pharmacology 2022;13:993022
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Xiong G, Feng Y, Yi X, Zhang X, Li X, Yang L, Yi Z, Sai B, Yang Z, Zhang Q, Kuang Y, Zhu Y
Frontiers in immunology 2022;13:989263
Frontiers in immunology 2022;13:989263
Abscopal effects of thoracic X-ray radiation on spermatogenesis in mice.
Lai PP, Jing YT, Guo L, Qin TZ, Xue YZ, Zhang ZW, Wang X, Miao X, Zhang W, Ding GR
Frontiers in physiology 2022;13:984429
Frontiers in physiology 2022;13:984429
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Wang J, Wang K, Ding L, Zhao P, Zhang C, Wang H, Yang Z, Liu Z
Frontiers in pharmacology 2022;13:969892
Frontiers in pharmacology 2022;13:969892
Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.
Jiang XL, Tai H, Xiao XS, Zhang SY, Cui SC, Qi SB, Hu DD, Zhang LN, Kuang JS, Meng XS, Li SM
Frontiers in endocrinology 2022;13:962154
Frontiers in endocrinology 2022;13:962154
Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway.
Liu F, Liu Y, Peng Q, Wang G, Tan Q, Ou Z, Xu Q, Liu C, Zuo D, Zhao J
Frontiers in pharmacology 2022;13:959497
Frontiers in pharmacology 2022;13:959497
Effect of ribose-glycated BSA on histone demethylation.
Xi M, Zhang L, Wei Y, Li T, Qu M, Hua Q, He R, Liu Y
Frontiers in genetics 2022;13:957937
Frontiers in genetics 2022;13:957937
Melatonin promotes sirtuin 1 expression and inhibits IRE1α-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes.
Qin K, Tang H, Ren Y, Yang D, Li Y, Huang W, Wu Y, Yin Z
Frontiers in pharmacology 2022;13:940629
Frontiers in pharmacology 2022;13:940629
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Yang T, Lin X, Li H, Zhou X, Fan F, Yang J, Luo Y, Liu X
Frontiers in pharmacology 2022;13:927871
Frontiers in pharmacology 2022;13:927871
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Cheng Z, Luo X, Zhu Z, Huang Y, Yan X
Frontiers in pharmacology 2022;13:906933
Frontiers in pharmacology 2022;13:906933
ABCA12 Promotes Proliferation and Migration and Inhibits Apoptosis of Pancreatic Cancer Cells Through the AKT Signaling Pathway.
Zheng S, Liu D, Wang F, Jin Y, Zhao S, Sun S, Wang S
Frontiers in genetics 2022;13:906326
Frontiers in genetics 2022;13:906326
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Xin M, Gao Q, Xiang X, Xu J, Jiao Y, Li X, Zhang X, Jia X
Frontiers in pharmacology 2022;13:890974
Frontiers in pharmacology 2022;13:890974
FGF2 Is Protective Towards Cisplatin-Induced KGN Cell Toxicity by Promoting FTO Expression and Autophagy.
Wang R, Wang L, Wang L, Cui Z, Cheng F, Wang W, Yang X
Frontiers in endocrinology 2022;13:890623
Frontiers in endocrinology 2022;13:890623
Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1.
Zhou J, Wang Y, Zhang L, Chen Q, Zhu X, Jiang P, Jiang N, Zhao W, Li B
Frontiers in pharmacology 2022;13:883445
Frontiers in pharmacology 2022;13:883445
High expression of B4GALT1 is associated with poor prognosis in acute myeloid leukemia.
Ren Z, Huang X, Lv Q, Lei Y, Shi H, Wang F, Wang M
Frontiers in genetics 2022;13:882004
Frontiers in genetics 2022;13:882004
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Hu X, Li C, Wang Q, Wei Z, Chen T, Wang Y, Li Y
Frontiers in pharmacology 2022;13:872057
Frontiers in pharmacology 2022;13:872057
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
Luo W, Tao Y, Chen S, Luo H, Li X, Qu S, Chen K, Zeng C
Frontiers in pharmacology 2022;13:860944
Frontiers in pharmacology 2022;13:860944
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke.
Huang W, Xie W, Zhong H, Cai S, Huang Q, Liu Y, Zeng Z, Liu Y
Frontiers in immunology 2022;13:859231
Frontiers in immunology 2022;13:859231
Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway.
Chen Y, Li T, Tan P, Shi H, Cheng Y, Cai T, Bai J, Du Y, Fu W
Frontiers in pharmacology 2022;13:857015
Frontiers in pharmacology 2022;13:857015
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Qin X, Liu B, Gao F, Hu Y, Chen Z, Xu J, Zhang X
Frontiers in physiology 2022;13:856699
Frontiers in physiology 2022;13:856699
Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells.
Li T, Shi L, Liu W, Hu X, Hui Y, Di M, Xue S, Zheng Y, Yao M, Li C, Meng K
Frontiers in pharmacology 2022;13:854526
Frontiers in pharmacology 2022;13:854526
HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance.
Shi B, Xu FF, Xiang CP, Li CY, Fan P, Wang H
Frontiers in pharmacology 2022;13:851401
Frontiers in pharmacology 2022;13:851401
Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.
Yu TT, Han N, Li LG, Peng XC, Li QR, Xu HZ, Wang XY, Yang ZY, Chen X, Wang MF, Li TF
Frontiers in pharmacology 2022;13:837784
Frontiers in pharmacology 2022;13:837784
Number 2 Feibi Recipe Inhibits H(2)O(2)-Mediated Oxidative Stress Damage of Alveolar Epithelial Cells by Regulating the Balance of Mitophagy/Apoptosis.
Gu X, Long Q, Wei W, Tong J, Li Z, Zhang Z, Jiao Y
Frontiers in pharmacology 2022;13:830554
Frontiers in pharmacology 2022;13:830554
Induction of Collagen I by CXCL10 in Ovarian Theca-Stroma Cells via the JNK Pathway.
Wang C, Sun Y
Frontiers in endocrinology 2022;13:823740
Frontiers in endocrinology 2022;13:823740
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Dong C, Chen Z, Zhu L, Bsoul N, Wu H, Jiang J, Chen X, Lai Y, Yu G, Gu Y, Guo X, Gao W
Frontiers in pharmacology 2022;13:809034
Frontiers in pharmacology 2022;13:809034
Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
Lin X, Wei Y, Li Y, Xiong Y, Fang B, Li C, Huang Q, Huang R, Wei J
Frontiers in pharmacology 2022;13:801982
Frontiers in pharmacology 2022;13:801982
Comprehensive analysis of hypoxia-related genes for prognosis value, immune status, and therapy in osteosarcoma patients.
Han T, Wu Z, Zhang Z, Liang J, Xia C, Yan H
Frontiers in pharmacology 2022;13:1088732
Frontiers in pharmacology 2022;13:1088732
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Li W, Yang K, Li B, Wang Y, Liu J, Chen D, Diao Y
Frontiers in pharmacology 2022;13:1060104
Frontiers in pharmacology 2022;13:1060104
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
Zhao P, Li X, Yang Q, Lu Y, Wang G, Yang H, Dong J, Zhang H
Frontiers in pharmacology 2022;13:1038802
Frontiers in pharmacology 2022;13:1038802
Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway.
Kourmaeva E, Sabry R, Favetta LA
Frontiers in endocrinology 2022;13:1028438
Frontiers in endocrinology 2022;13:1028438
BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model.
Lu Z, Sun GF, Pan XA, Qu XH, Yang P, Chen ZP, Han XJ, Wang T
Frontiers in pharmacology 2022;13:1025551
Frontiers in pharmacology 2022;13:1025551
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Xia N, Zheng W, Jiang S, Cao Q, Luo J, Zhang J, Xu Y, Sun S, Zhang K, Chen N, Meurens F, Zhu J
Frontiers in immunology 2022;13:1021384
Frontiers in immunology 2022;13:1021384
Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats.
Ding H, Liu C, Zhang S, Li B, Xu Q, Shi B, Li S, Dong S, Ma X, Zhang Y, Zhong M, Zhang G
Frontiers in endocrinology 2022;13:1015819
Frontiers in endocrinology 2022;13:1015819
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction.
Zhao J, Xu X, Yang X
Frontiers in pharmacology 2022;13:1010036
Frontiers in pharmacology 2022;13:1010036
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Zheng W, Wang K, Wu Y, Yan G, Zhang C, Li Z, Wang L, Chen S
Theranostics 2022;12(17):7289-7306
Theranostics 2022;12(17):7289-7306
Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention.
Wang X, Han M, Wang S, Sun Y, Zhao W, Xue Z, Liang X, Huang B, Li G, Chen A, Li X, Wang J
Theranostics 2022;12(12):5451-5469
Theranostics 2022;12(12):5451-5469
Investigation of the inhibition effect of 1,2,3,4,6-pentagalloyl-β-D-glucose on gastric cancer cells based on a network pharmacology approach and experimental validation.
Bi JH, Jiang YH, Ye SJ, Wu MR, Yi Y, Wang HX, Wang LM
Frontiers in oncology 2022;12:934958
Frontiers in oncology 2022;12:934958
CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.
Cheng J, Zhang Y, Wan R, Zhou J, Wu X, Fan Q, He J, Tan W, Deng Y
Frontiers in oncology 2022;12:919108
Frontiers in oncology 2022;12:919108
Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum Stress.
Tan M, Wang H, Gao C, Jiang Z, Yin Y, Xing R, Hu L, Xu J, Zhang M, Xie Y
Frontiers in oncology 2022;12:844214
Frontiers in oncology 2022;12:844214
The Novel lncRNA RP9P Promotes Colorectal Cancer Progression by Modulating miR-133a-3p/FOXQ1 Axis.
Jin Z, Liu B, Lin B, Yang R, Wu C, Xue W, Zou X, Qian J
Frontiers in oncology 2022;12:843064
Frontiers in oncology 2022;12:843064
Hinokiflavone Inhibits Growth of Esophageal Squamous Cancer By Inducing Apoptosis via Regulation of the PI3K/AKT/mTOR Signaling Pathway.
Guo J, Zhang S, Wang J, Zhang P, Lu T, Zhang L
Frontiers in oncology 2022;12:833719
Frontiers in oncology 2022;12:833719
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Wang FF, Zhao PY, He XJ, Jiang K, Wang TS, Xiao JW, Sun DB, Guo DH
Frontiers in cellular and infection microbiology 2022;12:827750
Frontiers in cellular and infection microbiology 2022;12:827750
Knockdown of Annexin A2 Enhances Radiosensitivity by Increasing G2/M-Phase Arrest, Apoptosis and Activating the p38 MAPK-HSP27 Pathway in Nasopharyngeal Carcinoma.
He H, Lin K, Zou C, Pan J, Fu W, Zhou Y, Lin H, Chen C, Su Y
Frontiers in oncology 2022;12:769544
Frontiers in oncology 2022;12:769544
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Wang H, Chen Y, Yuan Q, Chen L, Dai P, Li X
Frontiers in oncology 2022;12:1053510
Frontiers in oncology 2022;12:1053510
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
Weng M, Shi C, Han H, Zhu H, Xiao Y, Guo H, Yu Z, Wu C
PeerJ 2022;10:e14042
PeerJ 2022;10:e14042
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
Therapeutic targeting of ARID1A and PI3K/AKT pathway alterations in cholangiocarcinoma.
Tessiri S, Techasen A, Kongpetch S, Namjan A, Loilome W, Chan-On W, Thanan R, Jusakul A
PeerJ 2022;10:e12750
PeerJ 2022;10:e12750
A nanobody-based molecular toolkit for ubiquitin-proteasome system explores the main role of survivin subcellular localization.
Miao H, Liu C, Ouyang H, Zhang P, Liu Y, Zhang C, Deng C, Fu Y, Niu J, Zheng W, You F, Yang Y, Ma X
Frontiers in bioengineering and biotechnology 2022;10:952237
Frontiers in bioengineering and biotechnology 2022;10:952237
A mitochondria-targeted nano-platform for pancreatic cancer therapy.
Tan X, Zhu X, Xu D, Shi Y, Wang Z, Cao M, Hu K, Zhao L, Zhao J, Miao M, Zeng H, Wu X
Frontiers in chemistry 2022;10:951434
Frontiers in chemistry 2022;10:951434
Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy.
Li W, Wang X, Liu T, Zhang Q, Cao J, Jiang Y, Sun Q, Li C, Wang W, Wang Y
Frontiers in cell and developmental biology 2022;10:813370
Frontiers in cell and developmental biology 2022;10:813370
TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
Zhang J, Zhou X, Wan D, Yu L, Chen X, Yan T, Wu Z, Zheng M, Zhu F, Zhu H
Frontiers in cell and developmental biology 2022;10:757042
Frontiers in cell and developmental biology 2022;10:757042
Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.
Zhang F, Wang S, Gao M, Li B, He Z, Tang T, Zhu Z, Liu S, Zhou Z
Frontiers in bioengineering and biotechnology 2022;10:1057429
Frontiers in bioengineering and biotechnology 2022;10:1057429
A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells.
Zhang W, Liu J, Li Y, Guo F
Cancer chemotherapy and pharmacology 2022 Sep;90(3):251-265
Cancer chemotherapy and pharmacology 2022 Sep;90(3):251-265
Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway.
Fang X, Han Q, Li S, Luo A
Heliyon 2022 Sep;8(9):e10326
Heliyon 2022 Sep;8(9):e10326
Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells.
Wang Y, Zhang Y, Li J, Zhao R, Long X, Li C, Liu W, Chen W, Shi B
In vitro cellular & developmental biology. Animal 2022 Sep;58(8):669-678
In vitro cellular & developmental biology. Animal 2022 Sep;58(8):669-678
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.
Pan H, Yang L, Bai H, Luo J, Deng Y
Journal of ginseng research 2022 Sep;46(5):636-645
Journal of ginseng research 2022 Sep;46(5):636-645
Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock.
Zhang MQ, Zhang Q, Yuan W, Wu JY, Liang Y, Qin HJ, Li CS
Chinese journal of integrative medicine 2022 Sep;28(9):794-801
Chinese journal of integrative medicine 2022 Sep;28(9):794-801
SERPINA5 promotes tumour cell proliferation by modulating the PI3K/AKT/mTOR signalling pathway in gastric cancer.
Fan M, Xiong X, Han L, Zhang L, Gao S, Liu L, Wang X, Huang C, Tong D, Yang J, Zhao L, Shao Y
Journal of cellular and molecular medicine 2022 Sep;26(18):4837-4846
Journal of cellular and molecular medicine 2022 Sep;26(18):4837-4846
Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.
Li Y, Wang Z
Experimental and therapeutic medicine 2022 Sep;24(3):567
Experimental and therapeutic medicine 2022 Sep;24(3):567
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158
Experimental eye research 2022 Sep;222:109158
Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.
Xia J, Wu S, Wu G, Yang J
Reproductive biology 2022 Sep;22(3):100679
Reproductive biology 2022 Sep;22(3):100679
Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.
Jiang T, Shen S, Wang L, Zhao M, Li Y, Huang S
Applied biochemistry and biotechnology 2022 Sep;194(9):4093-4104
Applied biochemistry and biotechnology 2022 Sep;194(9):4093-4104
Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Li X, Li Q, Xiong B, Chen H, Wang X, Zhang D
Pharmacological research 2022 Sep;183:106368
Pharmacological research 2022 Sep;183:106368
Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.
Zhang Y, Chen G, Yan Z, Wang L, Wang D
Journal of cancer research and therapeutics 2022 Sep;18(5):1380-1386
Journal of cancer research and therapeutics 2022 Sep;18(5):1380-1386
Chaihujialonggumulitang shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of oxidative stress and apoptosis.
Shi J, Hou J, Sun Y, Jia Z, Zhou Y, Wang C, Zhao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113437
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113437
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.
Zhou Y, Lu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
Ma T, Cheng H, Li T, Chen Y, Cai T, Bai J, Wu Z, Xia X, Liang T, Du Y, Fu W
Bioorganic chemistry 2022 Sep;126:105899
Bioorganic chemistry 2022 Sep;126:105899
MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression.
Gao X, Fan S, Zhang X
Leukemia research 2022 Sep;120:106906
Leukemia research 2022 Sep;120:106906
SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis.
Long Q, Li L, Yang H, Lu Y, Yang H, Zhu Y, Tang Y, Liu C, Yuan J
International immunopharmacology 2022 Sep;110:109024
International immunopharmacology 2022 Sep;110:109024
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
Tong Q, Yi M, Kong P, Xu L, Huang W, Niu Y, Gan X, Zhan H, Tian R, Yan D
Cancer cell international 2022 Sep 6;22(1):278
Cancer cell international 2022 Sep 6;22(1):278
Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Wu S, Edwards H, Wang D, Liu S, Qiao X, Carter J, Wang Y, Taub JW, Wang G, Ge Y
Cells 2022 Sep 3;11(17)
Cells 2022 Sep 3;11(17)
Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy.
Liang M, Ji Y, Zhang L, Wang X, Hu C, Zhang J, Zhu Y, Mo JQ, Guan MX
Human molecular genetics 2022 Sep 29;31(19):3299-3312
Human molecular genetics 2022 Sep 29;31(19):3299-3312
A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.
Wang X, Liu Y, Xue C, Hu Y, Zhao Y, Cai K, Li M, Luo Z
Nature communications 2022 Sep 28;13(1):5685
Nature communications 2022 Sep 28;13(1):5685
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model.
Shen Z, Wang W, Chen J, Chen B, Tang Y, Hou J, Li J, Liu S, Mei Y, Zhang L, Lu S
Journal of nanobiotechnology 2022 Sep 24;20(1):422
Journal of nanobiotechnology 2022 Sep 24;20(1):422
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer.
Lu J, Shuai B, Shou Z, Guo W, Zhou C, Ouyang X, Zhou H, Li J, Cui J, Jiang F, Jin KY, Sarapultsev A, Li F, Zhang G, Luo S, Hu D
Cancers 2022 Sep 24;14(19)
Cancers 2022 Sep 24;14(19)
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)
Cancers 2022 Sep 23;14(19)
Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome.
Zhang Y, Chen D, Wang D, Wang L, Weng Y, Wang H, Wu X, Wang Y
Journal of clinical medicine 2022 Sep 23;11(19)
Journal of clinical medicine 2022 Sep 23;11(19)
FTH1- and SAT1-Induced Astrocytic Ferroptosis Is Involved in Alzheimer's Disease: Evidence from Single-Cell Transcriptomic Analysis.
Dang Y, He Q, Yang S, Sun H, Liu Y, Li W, Tang Y, Zheng Y, Wu T
Pharmaceuticals (Basel, Switzerland) 2022 Sep 22;15(10)
Pharmaceuticals (Basel, Switzerland) 2022 Sep 22;15(10)
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Li H, Zhang M, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y, Zhang S
Food & function 2022 Sep 22;13(18):9576-9588
Food & function 2022 Sep 22;13(18):9576-9588
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
He D, Liu Y, Li J, Wang H, Ye B, He Y, Li Z, Gao X, Fu S, Liu D
Cells 2022 Sep 19;11(18)
Cells 2022 Sep 19;11(18)
Zearalenone Promotes LPS-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Accelerates Bovine Mammary Epithelial Cell Apoptosis.
Fu Y, Jin Y, Tian Y, Yu H, Wang R, Qi H, Feng B, Zhang J
International journal of molecular sciences 2022 Sep 18;23(18)
International journal of molecular sciences 2022 Sep 18;23(18)
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Lin Y, Zhang Q, Xie B, Jiang H, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Liu J, Shi D, Ma Q, Zhao P
Journal of ethnopharmacology 2022 Sep 15;295:115398
Journal of ethnopharmacology 2022 Sep 15;295:115398
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
Chang X, Wang J, Bian J, Liu Z, Guo M, Li Z, Wu Y, Zhai X, Zuo D
Toxicology and applied pharmacology 2022 Sep 1;450:116156
Toxicology and applied pharmacology 2022 Sep 1;450:116156
A derivant of ginsenoside CK and its inhibitory effect on hepatocellular carcinoma.
Zhang J, Tong Y, Lu X, Dong F, Ma X, Yin S, He Y, Liu Y, Liu Q, Fan D
Life sciences 2022 Sep 1;304:120698
Life sciences 2022 Sep 1;304:120698
Oleuropein attenuates testicular ischemia-reperfusion by inhibiting apoptosis and inflammation.
Xu LZ, He KX, Ning JZ, Cheng F
Tissue & cell 2022 Oct;78:101876
Tissue & cell 2022 Oct;78:101876
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Chen TY, Zheng SK
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
Fu W, Chen S, Zhang Z, Chen Y, You X, Li Q
Andrologia 2022 Oct;54(9):e14502
Andrologia 2022 Oct;54(9):e14502
Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.
Wang Y, Wang HL, Lin ZP, Zhong JF, Chen KL, Duan X
Molecular biology reports 2022 Oct;49(10):9297-9305
Molecular biology reports 2022 Oct;49(10):9297-9305
TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
Xie H, Shi Y, Zhou Y, Liu H
Molecular biology reports 2022 Oct;49(10):9181-9194
Molecular biology reports 2022 Oct;49(10):9181-9194
Yajieshaba prevents lipopolysaccharide-induced intestinal barrier injuryanti-inflammatory and anti-apoptosis.
Liping Y, Xinglin YU, Chao Z, Pu C, Xiaohua D
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):707-714
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):707-714
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Zhao X, Shu D, Sun W, Si S, Ran W, Guo B, Cui L
Cancer communications (London, England) 2022 Oct;42(10):987-1007
Cancer communications (London, England) 2022 Oct;42(10):987-1007
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen-glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway.
Ren X, Yu J, Guo L, Zhang Z
Metabolic brain disease 2022 Oct;37(7):2417-2429
Metabolic brain disease 2022 Oct;37(7):2417-2429
Effect of NMB-regulated ERK1/2 and p65 signaling pathway on proliferation and apoptosis of cervical cancer.
Zeng R, Xiong X
Pathology, research and practice 2022 Oct;238:154104
Pathology, research and practice 2022 Oct;238:154104
Protective Effect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells.
Wang R, Shi Z, Li J, Tang D, Qin S, Guo Y
Biological trace element research 2022 Oct;200(10):4419-4429
Biological trace element research 2022 Oct;200(10):4419-4429
Matrix metalloproteinase-7 promotes chronic kidney disease progression via the induction of inflammasomes and the suppression of autophagy.
Zheng CM, Lu KC, Chen YJ, Li CY, Lee YH, Chiu HW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113565
Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2.
Zhong HY, Yuan C, Liu XL, Wang QQ, Li X, Zhao YC, Li X, Liu DD, Zheng TF, Zhang M
The international journal of biochemistry & cell biology 2022 Oct;151:106278
The international journal of biochemistry & cell biology 2022 Oct;151:106278
Polymyxin B Reduces Brain Injury in Ischemic Stroke Rat Through a Mechanism Involving Targeting ESCRT-III Machinery and RIPK1/RIPK3/MLKL Pathway.
Tian J, Zhang YY, Peng YW, Liu B, Zhang XJ, Hu ZY, Hu CP, Luo XJ, Peng J
Journal of cardiovascular translational research 2022 Oct;15(5):1129-1142
Journal of cardiovascular translational research 2022 Oct;15(5):1129-1142
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model.
Xiao S, Zhong N, Yang Q, Li A, Tong W, Zhang Y, Yao G, Wang S, Liu J, Liu Z
International immunopharmacology 2022 Oct;111:109163
International immunopharmacology 2022 Oct;111:109163
SCO-spondin-derived peptide NX210 rescues neurons from cerebral ischemia/reperfusion injury through modulating the Integrin-β1 mediated PI3K/Akt pathway.
Yang L, Zhu J, Yang L, Gan Y, Hu D, Zhao J, Zhao Y
International immunopharmacology 2022 Oct;111:109079
International immunopharmacology 2022 Oct;111:109079
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Hao M, Ding C, Peng X, Chen H, Dong L, Zhang Y, Chen X, Liu W, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
Xanthotoxol suppresses non-small cell lung cancer progression and might improve patients' prognosis.
Lin X, Liu J, Zou Y, Tao C, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154364
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154364
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Ischemia-Reperfusion Injury and Promote Survival of Skin Flaps in Rats.
Niu Q, Yang Y, Li D, Guo W, Wang C, Xu H, Feng Z, Han Z
Life (Basel, Switzerland) 2022 Oct 9;12(10)
Life (Basel, Switzerland) 2022 Oct 9;12(10)
Indole-3-propionic Acid Attenuates HI-Related Blood-Brain Barrier Injury in Neonatal Rats by Modulating the PXR Signaling Pathway.
Zhao Q, Chen T, Ni C, Hu Y, Nan Y, Lin W, Liu Y, Zheng F, Shi X, Lin Z, Zhu J, Lin Z
ACS chemical neuroscience 2022 Oct 5;13(19):2897-2912
ACS chemical neuroscience 2022 Oct 5;13(19):2897-2912
Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury.
Wang T, Zhou T, Xu M, Wang S, Wu A, Zhang M, Zhou YL, Shi J
Journal of nanobiotechnology 2022 Oct 4;20(1):434
Journal of nanobiotechnology 2022 Oct 4;20(1):434
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Tang X, Liang Y, Sun G, He Q, Hou Z, Jiang X, Gao P, Qu H
Cell death & disease 2022 Oct 4;13(10):848
Cell death & disease 2022 Oct 4;13(10):848
Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.
Jiang XL, Tai H, Kuang JS, Zhang JY, Cui SC, Lu YX, Qi SB, Zhang SY, Li SM, Chen JP, Meng XS
Aging 2022 Oct 27;14(20):8321-8345
Aging 2022 Oct 27;14(20):8321-8345
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma.
Gao Z, Li M, Yao F, Xia X, Duan T, Meng J, Huang Y, He Y, Saro A, Huang J
International journal of molecular sciences 2022 Oct 26;23(21)
International journal of molecular sciences 2022 Oct 26;23(21)
Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils.
Zhang SS, Liu M, Liu DN, Shang YF, Du GH, Wang YH
International journal of molecular sciences 2022 Oct 21;23(20)
International journal of molecular sciences 2022 Oct 21;23(20)
Polygonatum cyrtonema Hua Polysaccharides Protect BV2 Microglia Relief Oxidative Stress and Ferroptosis by Regulating NRF2/HO-1 Pathway.
Li J, Wang X, Zhou R, Cheng F, Tang X, Lao J, Xu L, He W, Wan D, Zeng H, Zhang S
Molecules (Basel, Switzerland) 2022 Oct 20;27(20)
Molecules (Basel, Switzerland) 2022 Oct 20;27(20)
Domino hepatocyte transplantation using explanted human livers with metabolic defects attenuates D-GalN/LPS-induced acute liver failure.
Zhou GP, Li SP, Jiang YZ, Sun J, Tan YL, Zeng ZG, Wei L, Qu W, Sun LY, Zhu ZJ
Journal of translational medicine 2022 Oct 20;20(1):479
Journal of translational medicine 2022 Oct 20;20(1):479
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Zhao Y, Lin J, Li J, Bwalya C, Xu Y, Niu Y, Zhang Y, Wu J, Xu Y, Chen J, Ye S, Lin L
International journal of molecular sciences 2022 Oct 18;23(20)
International journal of molecular sciences 2022 Oct 18;23(20)
Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice.
Li F, Wang Y, Xu M, Hu N, Miao J, Zhao Y, Wang L
Ecotoxicology and environmental safety 2022 Oct 15;245:114093
Ecotoxicology and environmental safety 2022 Oct 15;245:114093
MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats.
Zhang F, Gou Z, Zhou Y, Huang L, Shao C, Wang M, Wu C, Lu L
Brain research bulletin 2022 Oct 15;189:139-150
Brain research bulletin 2022 Oct 15;189:139-150
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Lv Q, Han X, Ni J, Ma Q, Dai R, Liu J, Liu J, Zhai Y, Shen Q, Sun L, Liu H, Rao J, Xu H
Cell death & disease 2022 Oct 13;13(10):867
Cell death & disease 2022 Oct 13;13(10):867
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
Chen Y, Liu H, Zheng Q, Li H, You H, Feng Y, Feng W
Life sciences 2022 Oct 1;306:120826
Life sciences 2022 Oct 1;306:120826
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM).
He Z, Cheng M, Hu J, Liu L, Liu P, Chen L, Cao D, Tang J
Journal of translational medicine 2022 Oct 1;20(1):443
Journal of translational medicine 2022 Oct 1;20(1):443
Knockdown of TTC9 inhibits the proliferation, migration and invasion, but induces the apoptosis of lung adenocarcinoma cells.
Huang X, Jiang L, Wen Z, Yuan M, Zhong Y
Heliyon 2022 Nov;8(11):e11254
Heliyon 2022 Nov;8(11):e11254
Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration.
Chen HW, Liu MQ, Zhang GZ, Zhang CY, Wang ZH, Lin AX, Kang JH, Liu WZ, Guo XD, Wang YD, Kang XW
Connective tissue research 2022 Nov;63(6):650-662
Connective tissue research 2022 Nov;63(6):650-662
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
Zhou Z, Dong Y, Li N, Niu M, Wang S, Zhou Y, Sun Z, Chu P, Tang Z
Cell biology international 2022 Nov;46(11):1801-1813
Cell biology international 2022 Nov;46(11):1801-1813
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
Liu N, Li Y, Yang Y, Shu L, Liu Y, Wu Y, Sun D, Kang Z, Zhang Y, Ni D, Wei Z, Li S, Yang M, Wang Y, Sun J, Yang X
Experimental neurology 2022 Nov;357:114180
Experimental neurology 2022 Nov;357:114180
S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.
Tao Q, Qiu X, Li C, Zhou J, Gu L, Zhang L, Pang J, Zhang L, Yin S, Jiang Y, Peng J
Experimental neurology 2022 Nov;357:114171
Experimental neurology 2022 Nov;357:114171
Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
Yang Z, Xu B, Wu S, Yang W, Luo R, Geng S, Xin Z, Jin W, Shen X, Gu X, Zhang H, Wang H
Human cell 2022 Nov;35(6):1797-1812
Human cell 2022 Nov;35(6):1797-1812
A novel synthetic chalcone derivative, 2,4,6-trimethoxy-4'-nitrochalcone (Ch-19), exerted anti-tumor effects through stimulating ROS accumulation and inducing apoptosis in esophageal cancer cells.
Yang Y, Wu H, Zou X, Chen Y, He R, Jin Y, Zhou B, Ge C, Yang Y
Cell stress & chaperones 2022 Nov;27(6):645-657
Cell stress & chaperones 2022 Nov;27(6):645-657
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
Tang Q, Xu F, Lin J, Zhang C, Liu X, Dong L, Zhao J, Zhu L, Lin T
Experimental eye research 2022 Nov;224:109221
Experimental eye research 2022 Nov;224:109221
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.
Kang J, Wang Y, Guo X, He X, Liu W, Chen H, Wang Z, Lin A, Kang X
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282
Effect of rapamycin treatment on oocyte in vitro maturation and embryonic development after parthenogenesis in yaks.
Zhang T, Wang L, Pan Y, He H, Wang J, Zhao T, Ding T, Wang Y, Zhao L, Han X, Fan J, Xu G, Cui Y, Yu S
Theriogenology 2022 Nov;193:128-135
Theriogenology 2022 Nov;193:128-135
Ellagic Acid Alleviates Mice Intestinal Ischemia-Reperfusion Injury: A Study Based on Transcriptomics Combined with Functional Experiments.
Fan S, Xu Y, Li K, Li B, Diao Y
Chemistry & biodiversity 2022 Nov;19(11):e202200345
Chemistry & biodiversity 2022 Nov;19(11):e202200345
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Zhan L, Zheng J, Meng J, Fu D, Pang L, Ji C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113778
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113778
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Wang Y, Zhu M, Liang J, Zhang N, Sun D, Li H, Chen L
Bioorganic chemistry 2022 Nov;128:106067
Bioorganic chemistry 2022 Nov;128:106067
Magnesium isoglycyrrhizinate ameliorates lipopolysaccharide-induced liver injury by upregulating autophagy and inhibiting inflammation via IL-22 expression.
Zhou X, Li X, Yi K, Liang C, Geng S, Zhu J, Xie C, Zhong C
Bioorganic chemistry 2022 Nov;128:106034
Bioorganic chemistry 2022 Nov;128:106034
Hyperglycemia promotes myocardial dysfunction via the ERS-MAPK10 signaling pathway in db/db mice.
Deng YW, Liu F, Li ZT, Gao JH, Zhao Y, Yang XL, Xia YL
Laboratory investigation; a journal of technical methods and pathology 2022 Nov;102(11):1192-1202
Laboratory investigation; a journal of technical methods and pathology 2022 Nov;102(11):1192-1202
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy.
Yi L, Shang XJ, Lv L, Wang Y, Zhang J, Quan C, Shi Y, Liu Y, Zhang L
Cell death & disease 2022 Nov 5;13(11):928
Cell death & disease 2022 Nov 5;13(11):928
Long-Term Consumption of Food-Derived Chlorogenic Acid Protects Mice against Acetaminophen-Induced Hepatotoxicity via Promoting PINK1-Dependent Mitophagy and Inhibiting Apoptosis.
Hu B, Li J, Gong D, Dai Y, Wang P, Wan L, Xu S
Toxics 2022 Nov 5;10(11)
Toxics 2022 Nov 5;10(11)
The effect of lncRNA MIR155HG-modified MSCs and exosome delivery to synergistically attenuate vein graft intimal hyperplasia.
Bai X, Qi Z, Zhu M, Lu Z, Zhao X, Zhang L, Song G
Stem cell research & therapy 2022 Nov 4;13(1):512
Stem cell research & therapy 2022 Nov 4;13(1):512
Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.
Liu X, Cheng C, Deng B, Liu M
Physiological research 2022 Nov 28;71(5):631-641
Physiological research 2022 Nov 28;71(5):631-641
Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.
Ma XY, Xu HQ, Zhao JF, Ruan Y, Chen B
International journal of molecular sciences 2022 Nov 26;23(23)
International journal of molecular sciences 2022 Nov 26;23(23)
MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis.
Xu P, Chang J, Ma G, Liao F, Xu T, Wu Y, Yin Z
BMC musculoskeletal disorders 2022 Nov 26;23(1):1020
BMC musculoskeletal disorders 2022 Nov 26;23(1):1020
Suffruticosol C-Mediated Autophagy and Cell Cycle Arrest via Inhibition of mTORC1 Signaling.
Qin S, Geng H, Wang G, Chen L, Xia C, Yao J, Bai Z, Deng L
Nutrients 2022 Nov 24;14(23)
Nutrients 2022 Nov 24;14(23)
6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer.
Mulati S, Jiang R, Wang J, Tao Y, Zhang W
Cells 2022 Nov 19;11(22)
Cells 2022 Nov 19;11(22)
WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC.
Wang R, Zhao J, Jin J, Tian Y, Lan L, Wang X, Zhu L, Wang J
Lipids in health and disease 2022 Nov 16;21(1):121
Lipids in health and disease 2022 Nov 16;21(1):121
Reactive Oxygen Species- and Cell-Free DNA-Scavenging Mn(3)O(4) Nanozymes for Acute Kidney Injury Therapy.
Meng L, Feng J, Gao J, Zhang Y, Mo W, Zhao X, Wei H, Guo H
ACS applied materials & interfaces 2022 Nov 16;14(45):50649-50663
ACS applied materials & interfaces 2022 Nov 16;14(45):50649-50663
CD93 promotes acute myeloid leukemia development and is a potential therapeutic target.
Jia J, Liu B, Wang D, Wang X, Song L, Ren Y, Guo Z, Ma K, Cui C
Experimental cell research 2022 Nov 15;420(2):113361
Experimental cell research 2022 Nov 15;420(2):113361
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Lan B, Zhao H, He Y, Zhao Z, Wang N, Gao Y
Experimental cell research 2022 Nov 15;420(2):113358
Experimental cell research 2022 Nov 15;420(2):113358
Integrated strategy of network pharmacology, molecular docking, HPLC-DAD and mice model for exploring active ingredients and pharmacological mechanisms of Penthorum chinense Pursh against alcoholic liver injury.
Jiang Y, Zhong M, Zhan H, Tao X, Zhang Y, Mao J, Geng Z, Gao B
Journal of ethnopharmacology 2022 Nov 15;298:115589
Journal of ethnopharmacology 2022 Nov 15;298:115589
Dietary N(ε)-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice.
Wang ZQ, Sun Z
World journal of diabetes 2022 Nov 15;13(11):972-985
World journal of diabetes 2022 Nov 15;13(11):972-985
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Zhang D, Li X, He X, Xing Y, Jiang B, Xiu Z, Bao Y, Dong Y
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
Zhao R, Ge Y, Gong Y, Li B, Xiao B, Zuo S
Aging 2022 Nov 11;14(22):9000-9019
Aging 2022 Nov 11;14(22):9000-9019
DJ-1 Protein Inhibits Apoptosis in Cerebral Ischemia by Regulating the Notch1 and Nuclear Factor Erythroid2-Related Factor 2 Signaling Pathways.
Wang T, Xue Y, Li Y, Gao S, Peng L, Zhao Y, Yu S
Neuroscience 2022 Nov 10;504:33-46
Neuroscience 2022 Nov 10;504:33-46
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
Duan SF, Zhang MM, Zhang X, Liu W, Zhang SH, Yang B, Dong Q, Han JG, Yu HL, Li T, Ji XY, Wu DD, Zhang XJ
Experimental cell research 2022 Nov 1;420(1):113341
Experimental cell research 2022 Nov 1;420(1):113341
Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.
Zhao J, Wu Q, Yang T, Nie L, Liu S, Zhou J, Chen J, Jiang Z, Xiao T, Yang J, Chu C
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556
Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway.
Yang X, Wang M, Zhou Q, Bai Y, Liu J, Yang J, Li L, Li G, Luo L
Molecular neurobiology 2022 May;59(5):2776-2798
Molecular neurobiology 2022 May;59(5):2776-2798
Maslinic Acid Inhibits Myocardial Ischemia-Reperfusion Injury-Induced Apoptosis and Necroptosis via Promoting Autophagic Flux.
Li L, Lin L, Lei S, Shi S, Chen C, Xia Z
DNA and cell biology 2022 May;41(5):487-497
DNA and cell biology 2022 May;41(5):487-497
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB.
He ST, Wang DX, Meng JJ, Cheng XF, Bi Q, Zhong GQ, Tu RH
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2022 May;35(5):1012-1020
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2022 May;35(5):1012-1020
Novel chloroquine derivative suppresses melanoma cell growth by DNA damage through increasing ROS levels.
Li J, Long J, Zhang J, Liu N, Yan B, Tang L, Chen X, Peng C
Journal of cellular and molecular medicine 2022 May;26(9):2579-2593
Journal of cellular and molecular medicine 2022 May;26(9):2579-2593
NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation.
Shao Y, Jiang Z, He D, Shen J
Journal of cellular and molecular medicine 2022 May;26(10):2831-2840
Journal of cellular and molecular medicine 2022 May;26(10):2831-2840
LncRNA SOX2OT facilitates LPS-induced inflammatory injury by regulating intercellular adhesion molecule 1 (ICAM1) via sponging miR-215-5p.
Zhu W, Peng F, Cui X, Li J, Sun C
Clinical immunology (Orlando, Fla.) 2022 May;238:109006
Clinical immunology (Orlando, Fla.) 2022 May;238:109006
Manganese Mitigates Heat Stress-Induced Apoptosis by Alleviating Endoplasmic Reticulum Stress and Activating the NRF2/SOD2 Pathway in Primary Chick Embryonic Myocardial Cells.
Qin S, Wang R, Tang D, Qin S, Guo Y, Shi Z
Biological trace element research 2022 May;200(5):2312-2320
Biological trace element research 2022 May;200(5):2312-2320
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.
Dai C, Li M, Sun T, Zhang Y, Wang Y, Shen Z, Velkov T, Tang S, Shen J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 May;163:112966
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 May;163:112966
Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation.
Duan X, Wen J, Zhang M, Wang C, Xiang Y, Wang L, Yu C, Deng G, Yan M, Zhang B, Fang P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112884
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112884
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Zhou S, Li J, Zhang X, Xiong W
Bioengineered 2022 May;13(5):13507-13519
Bioengineered 2022 May;13(5):13507-13519
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Guo H, Guo X, Jiang S
Bioengineered 2022 May;13(5):12248-12260
Bioengineered 2022 May;13(5):12248-12260
Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway.
Wen X, Li S, Zhang Y, Zhu L, Xi X, Zhang S, Li Y
Bioengineered 2022 May;13(5):11767-11781
Bioengineered 2022 May;13(5):11767-11781
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Fan Y, Fan H, Li P, Liu Q, Huang L, Zhou Y
Bioengineered 2022 May;13(5):11517-11529
Bioengineered 2022 May;13(5):11517-11529
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage.
Sun Q, Gui A, Zou A, Yan Y, Qiu S, Zhu S, Liu W, Zuo J, Zhang Q, Yang L
Annals of translational medicine 2022 May;10(10):570
Annals of translational medicine 2022 May;10(10):570
Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow.
Liu Y, Xiang H, Xiong W, Ouyang J, Liu H, Zhao S, Xiao J, Li J, Shu Z, Wang X, Liu H, Zhang J, Fan J, Li Y, Chen S, Lu H
Diabetes & vascular disease research 2022 May-Jun;19(3):14791641221102513
Diabetes & vascular disease research 2022 May-Jun;19(3):14791641221102513
Label-free Raman spectroscopy characterizes signatures of inflammation and fibrosis in the silicosis.
Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X
Biochemical and biophysical research communications 2022 May 28;606:114-120
Biochemical and biophysical research communications 2022 May 28;606:114-120
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615
Cancer letters 2022 May 28;534:215615
Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.
Yao R, Zhang M, Zhou J, Liu L, Zhang Y, Gao J, Xu K
Cell communication and signaling : CCS 2022 May 26;20(1):73
Cell communication and signaling : CCS 2022 May 26;20(1):73
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6
Molecular cell 2022 May 19;82(10):1821-1835.e6
A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin.
Yang XX, Xu X, Wang MF, Xu HZ, Peng XC, Han N, Yu TT, Li LG, Li QR, Chen X, Wen Y, Li TF
Journal of nanobiotechnology 2022 May 14;20(1):230
Journal of nanobiotechnology 2022 May 14;20(1):230
Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment.
Zhang LX, Tian YG, Zhao P, Feng SX, Han XX, Li JS
Journal of ethnopharmacology 2022 May 10;289:115022
Journal of ethnopharmacology 2022 May 10;289:115022
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.
Wang R, Ren Q, Gao D, Paudel YN, Li X, Wang L, Zhang P, Wang B, Shang X, Jin M
Journal of ethnopharmacology 2022 May 10;289:115018
Journal of ethnopharmacology 2022 May 10;289:115018
Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1.
Chen D, Jiang X
Experimental cell research 2022 May 1;414(1):113066
Experimental cell research 2022 May 1;414(1):113066
Dietary phillygenin supplementation ameliorates aflatoxin B(1)-induced oxidative stress, inflammation, and apoptosis in chicken liver.
Guo J, Yan WR, Tang JK, Jin X, Xue HH, Wang T, Zhang LW, Sun QY, Liang ZX
Ecotoxicology and environmental safety 2022 May 1;236:113481
Ecotoxicology and environmental safety 2022 May 1;236:113481
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.
Hu B, Wang P, Zhang S, Liu W, Lv X, Shi D, Zhao L, Liu H, Wang B, Chen S, Shao Z
Experimental & molecular medicine 2022 Mar;54(3):309-323
Experimental & molecular medicine 2022 Mar;54(3):309-323
Chlorin e6 mediated photodynamic therapy triggers resistance through ATM-related DNA damage response in lung cancer cells.
Ma QL, Shen MO, Han N, Xu HZ, Peng XC, Li QR, Yu TT, Li LG, Xu X, Liu B, Chen X, Wang MF, Li TF
Photodiagnosis and photodynamic therapy 2022 Mar;37:102645
Photodiagnosis and photodynamic therapy 2022 Mar;37:102645
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.
Liu MX, Luo L, Fu JH, He JY, Chen MY, He ZJ, Jia J
Experimental neurology 2022 Mar;349:113952
Experimental neurology 2022 Mar;349:113952
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Wang F, Luo Y, Zhang L, Younis M, Yuan L
Cancer gene therapy 2022 Mar;29(3-4):292-303
Cancer gene therapy 2022 Mar;29(3-4):292-303
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Veterinary microbiology 2022 Mar;266:109367
Veterinary microbiology 2022 Mar;266:109367
Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway.
Jiang H, Niu Y, He Y, Li X, Xu Y, Liu X
Journal of cellular physiology 2022 Mar;237(3):1948-1963
Journal of cellular physiology 2022 Mar;237(3):1948-1963
PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer.
Yin S, Chen Y, Tong H, Li T, Qin Z, Zhu J, He W
Oncology letters 2022 Mar;23(3):101
Oncology letters 2022 Mar;23(3):101
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.
Wu N, Chen S, Luo Q, Jiang Z, Wang X, Li Y, Qiu J, Yu K, Yang Y, Zhuang J
Experimental eye research 2022 Mar;216:108955
Experimental eye research 2022 Mar;216:108955
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis.
Liu J, Li L, Xie P, Zhao X, Shi D, Zhang Y, Pan C, Li T
Free radical biology & medicine 2022 Mar;181:72-81
Free radical biology & medicine 2022 Mar;181:72-81
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Li Y, Jiang Y, Zhou W, Wu Y, Zhang S, Ding G, Zhang Y, Zhang A, Huang S, Jia Z, You R
Free radical biology & medicine 2022 Mar;181:270-287
Free radical biology & medicine 2022 Mar;181:270-287
Expressions and significances of CTSL, the target of COVID-19 on GBM.
Dong Q, Li Q, Duan L, Wang H, Yan Y, Yin H, Niu L, Zhang H, Wang B, Yuan G, Pan Y
Journal of cancer research and clinical oncology 2022 Mar;148(3):599-608
Journal of cancer research and clinical oncology 2022 Mar;148(3):599-608
In situ injectable hydrogel-loaded drugs induce anti-tumor immune responses in melanoma immunochemotherapy.
Li J, Luo G, Zhang C, Long S, Guo L, Yang G, Wang F, Zhang L, Shi L, Fu Y, Zhang Y
Materials today. Bio 2022 Mar;14:100238
Materials today. Bio 2022 Mar;14:100238
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Zhang J, Shang L, Jiang W, Wu W
Bioengineered 2022 Mar;13(3):7904-7918
Bioengineered 2022 Mar;13(3):7904-7918
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Wang Y, Zhao L, Qiu D, Shi Y, Duan H
Bioengineered 2022 Mar;13(3):5880-5891
Bioengineered 2022 Mar;13(3):5880-5891
Oxycodone relieves permeability damage and apoptosis of oxygen-glucose deprivation/reoxygenation-induced brain microvascular endothelial cells through ras homolog family member A (RhoA)/ Rho-associated coiled-coil containing kinases (ROCK)/ myosin light chain 2 (MLC2) signal.
Shao F, Han D, Shen Y, Bian W, Zou L, Hu Y, Sun W
Bioengineered 2022 Mar;13(3):5205-5215
Bioengineered 2022 Mar;13(3):5205-5215
Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.
Xie HX, Wang YH, Zhang JH, Zhang J, Zhong YN, Ge YX, Cheng ZQ, Jiang CS, Meng N
Bioorganic chemistry 2022 Mar;120:105606
Bioorganic chemistry 2022 Mar;120:105606
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Ying J, Pan R, Tang Z, Zhu J, Ren P, Lou Y, Zhang E, Huang D, Hu P, Li D, Bao Q, Li P
Cancer medicine 2022 Mar;11(6):1454-1464
Cancer medicine 2022 Mar;11(6):1454-1464
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Du L, Hao YM, Yang YH, Zheng Y, Wu ZJ, Zhou MQ, Wang BZ, Wang YM, Wu H, Su GH
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2911-2922
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2911-2922
Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways.
Pan B, Xia Y, Gao Z, Zhao G, Wang L, Fang S, Liu L, Yan S
Chinese medicine 2022 Mar 9;17(1):36
Chinese medicine 2022 Mar 9;17(1):36
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice.
Peng X, Chen L, Wang Z, He Y, Ruganzu JB, Guo H, Zhang X, Ji S, Zheng L, Yang W
European journal of pharmacology 2022 Mar 5;918:174772
European journal of pharmacology 2022 Mar 5;918:174772
Blocking protease-activated receptor 4 alleviates liver injury induced by brain death.
Fang H, Yuan Z, Zhu Y, Tang H, Pang C, Li J, Shi J, Guo W, Zhang S
Biochemical and biophysical research communications 2022 Mar 5;595:47-53
Biochemical and biophysical research communications 2022 Mar 5;595:47-53
Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
Qin J, Xia PF, Yuan XZ, Wang SG
Journal of hazardous materials 2022 Mar 5;425:127842
Journal of hazardous materials 2022 Mar 5;425:127842
Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.
Cao Z, Wu Z, Duan T, Tang C, Huang D, Hu X
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):370-377
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):370-377
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Wang L, Chen J, Hu Y, Liao A, Zheng W, Wang X, Lan J, Shen J, Wang S, Yang F, Wang Y, Li Y, Chen D
Translational psychiatry 2022 Mar 22;12(1):114
Translational psychiatry 2022 Mar 22;12(1):114
Autophagy Promotes α-Amanitin-Induced Apoptosis of Hepa1-6 Liver Cells.
Gu X, Zhang L, Sun W, Liu K, Xu H, Wu P, Gui M, Qu W
Chemical research in toxicology 2022 Mar 21;35(3):392-401
Chemical research in toxicology 2022 Mar 21;35(3):392-401
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Zhong Y, Liu J, Sun D, Guo T, Yao Y, Xia X, Shi C, Peng X
Food & function 2022 Mar 21;13(6):3660-3673
Food & function 2022 Mar 21;13(6):3660-3673
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Meng N, Chen K, Wang Y, Hou J, Chu W, Xie S, Yang F, Sun C
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway.
Liu Z, Wang Q, Zhai G, Ke S, Yu X, Guo J
Cancer cell international 2022 Mar 19;22(1):127
Cancer cell international 2022 Mar 19;22(1):127
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
Kong Q, Yan X, Cheng M, Jiang X, Xu L, Shen L, Yu H, Sun L
International journal of molecular sciences 2022 Mar 18;23(6)
International journal of molecular sciences 2022 Mar 18;23(6)
Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy.
Tang X, Peng H, Xu P, Zhang L, Fu R, Tu H, Guo X, Huang K, Lu J, Chen H, Dong Z, Dai L, Luo J, Chen Q
Molecular therapy oncolytics 2022 Mar 17;24:707-718
Molecular therapy oncolytics 2022 Mar 17;24:707-718
Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway.
Fan H, He J, Bai Y, He Q, Zhang T, Zhang J, Yang G, Xu Z, Hu J, Yao G
Journal of ovarian research 2022 Mar 17;15(1):34
Journal of ovarian research 2022 Mar 17;15(1):34
Long noncoding RNA H19 mediates neural stem/progenitor cells proliferation, differentiation and apoptosis through the p53 signaling pathway after ischemic stroke.
Gan L, Liao S, Tong Y, Li W, Peng W, Deng S
Biochemical and biophysical research communications 2022 Mar 15;597:8-15
Biochemical and biophysical research communications 2022 Mar 15;597:8-15
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Zhu M, Niu J, Jiang J, Dong T, Chen Y, Yang X, Liu P
Life sciences 2022 Mar 15;293:120358
Life sciences 2022 Mar 15;293:120358
Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells.
Wang J, Zheng K, Jin Y, Fu Y, Wang R, Zhang J
Toxins 2022 Mar 15;14(3)
Toxins 2022 Mar 15;14(3)
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway.
Wan Z, Yang H, Chen P, Wang Z, Cai Y, Yao X, Wang F, Zhang Y
Cells 2022 Mar 14;11(6)
Cells 2022 Mar 14;11(6)
Staphylococcus aureus Induces Goat Endometrial Epithelial Cells Apoptosis via the Autophagy and Endoplasmic Reticulum Stress Pathway.
Yi Y, Gao K, Zhang R, Lin P, Wang A, Jin Y
Animals : an open access journal from MDPI 2022 Mar 11;12(6)
Animals : an open access journal from MDPI 2022 Mar 11;12(6)
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Xu P, Li X, Tang C, Wang T, Xu J
Experimental cell research 2022 Mar 1;412(1):113018
Experimental cell research 2022 Mar 1;412(1):113018
Interleukin-4 activates the PI3K/AKT signaling to promote apoptosis and inhibit the proliferation of granulosa cells.
Han Y, Yao R, Yang Z, Li S, Meng W, Zhang Y, Zhang Y, Luo H
Experimental cell research 2022 Mar 1;412(1):113002
Experimental cell research 2022 Mar 1;412(1):113002
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Gu W, Wang L, Deng G, Gu X, Tang Z, Li S, Jin W, Yang J, Guo X, Li Q
Toxicology letters 2022 Mar 1;357:11-19
Toxicology letters 2022 Mar 1;357:11-19
Nephrotoxicity evaluation of 3-monochloropropane-1,2-diol exposure in Sprague-Dawley rats using data-independent acquisition-based quantitative proteomics analysis.
Jin C, Min F, Zhong Y, Sun D, Luo R, Liu Q, Peng X
Toxicology letters 2022 Mar 1;356:110-120
Toxicology letters 2022 Mar 1;356:110-120
Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.
Meng M, Jia R, Wei M, Meng X, Zhang X, Du R, Sun W, Wang L, Song L
Ecotoxicology and environmental safety 2022 Mar 1;232:113228
Ecotoxicology and environmental safety 2022 Mar 1;232:113228
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
Inhibition of calpain reduces cell apoptosis by suppressing mitochondrial fission in acute viral myocarditis.
Shi H, Yu Y, Liu X, Yu Y, Li M, Wang Y, Zou Y, Chen R, Ge J
Cell biology and toxicology 2022 Jun;38(3):487-504
Cell biology and toxicology 2022 Jun;38(3):487-504
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Zhai X, Dai T, Chi Z, Zhao Z, Wu G, Yang S, Dong D
Environmental toxicology 2022 Jun;37(6):1332-1342
Environmental toxicology 2022 Jun;37(6):1332-1342
microRNA-486-5p is implicated in the cisplatin-induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1.
Lin FY, Han ST, Yu WM, Rao T, Ruan Y, Yuan R, Li HY, Ning JZ, Xia YQ, Xie JN, Qi YC, Zhou XJ, Cheng F
Journal of biochemical and molecular toxicology 2022 Jun;36(6):e23039
Journal of biochemical and molecular toxicology 2022 Jun;36(6):e23039
Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.
Yuan F, Zhang S, Sun Q, Ye L, Xu Y, Xu Z, Deng G, Zhang S, Liu B, Chen Q
CNS neuroscience & therapeutics 2022 Jun;28(6):897-912
CNS neuroscience & therapeutics 2022 Jun;28(6):897-912
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Qian M, Feng ZQ, Zheng RN, Hu KW, Sun JZ, Sun HB, Dai L
Chinese journal of natural medicines 2022 Jun;20(6):432-442
Chinese journal of natural medicines 2022 Jun;20(6):432-442
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
Shi L, Wang X, Duan Y, Li K, Ren Y
Theriogenology 2022 Jun;185:43-49
Theriogenology 2022 Jun;185:43-49
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Zhang D, Ren Y, He Y, Chang R, Guo S, Ma S, Guan F, Yao M
Materials today. Bio 2022 Jun;15:100278
Materials today. Bio 2022 Jun;15:100278
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313
European journal of medicinal chemistry 2022 Jun 5;236:114313
A pH-Dependent rhodamine fluorophore with antiproliferative activity of bladder cancer in Vitro/Vivo and apoptosis mechanism.
Lu D, Yang T, Tang N, Li C, Song Y, Wang L, Wong WY, Yin SF, Xing Y, Kambe N, Qiu R
European journal of medicinal chemistry 2022 Jun 5;236:114293
European journal of medicinal chemistry 2022 Jun 5;236:114293
Glis2 inhibits the epithelial-mesenchymal transition and apoptosis of renal tubule cells by regulating the β-catenin signalling pathway in diabetic kidney disease.
He L, Li Q, Du C, Xue Y, Yu P
Biochemical and biophysical research communications 2022 Jun 4;607:73-80
Biochemical and biophysical research communications 2022 Jun 4;607:73-80
Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.
Peng J, Cai Z, Wang Q, Zhou J, Xu J, Pan D, Chen T, Zhang G, Tao L, Chen Y, Shen X
Molecules (Basel, Switzerland) 2022 Jun 4;27(11)
Molecules (Basel, Switzerland) 2022 Jun 4;27(11)
LncRNA SNHG16 promotes colorectal cancer proliferation by regulating ABCB1 expression through sponging miR-214-3p.
Tan P, Xu M, Nie J, Qin J, Liu X, Sun H, Wang S, Pan Y
Journal of biomedical research 2022 Jun 28;36(4):231-241
Journal of biomedical research 2022 Jun 28;36(4):231-241
Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer.
Wang YC, Zhang RH, Hu SC, Zhang H, Yang D, Zhang WL, Zhao YL, Cui DB, Li YJ, Pan WD, Liao SG, Zhou M
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
Khan NH, Wang D, Wang W, Shahid M, Khattak S, Ngowi EE, Sarfraz M, Ji XY, Zhang CY, Wu DD
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
Chen Z, Wu H, Yang J, Li B, Ding J, Cheng S, Bsoul N, Zhang C, Li J, Liu H, Lin D, Gao W
Communications biology 2022 Jun 22;5(1):616
Communications biology 2022 Jun 22;5(1):616
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
Anti-aging effect of phlorizin on D-galactose-induced aging in mice through antioxidant and anti-inflammatory activity, prevention of apoptosis, and regulation of the gut microbiota.
Chen H, Dong L, Chen X, Ding C, Hao M, Peng X, Zhang Y, Zhu H, Liu W
Experimental gerontology 2022 Jun 15;163:111769
Experimental gerontology 2022 Jun 15;163:111769
Comparative and mechanistic study of pharmacodynamic difference in anti-breast cancer activity between water and liquor extracts of Xiaojin Pills.
Liu H, Cao B, Li C, Han L, Xu H, Lin J, Zhang D, Xu R
Journal of ethnopharmacology 2022 Jun 12;291:115104
Journal of ethnopharmacology 2022 Jun 12;291:115104
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis.
Deng R, Wang Y, Bu Y, Wu H
Molecular medicine (Cambridge, Mass.) 2022 Jun 11;28(1):64
Molecular medicine (Cambridge, Mass.) 2022 Jun 11;28(1):64
Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.
Zhou T, Yang X, Wang T, Xu M, Huang Z, Yu R, Jiang Y, Zhou Y, Shi J
Membranes 2022 Jun 10;12(6)
Membranes 2022 Jun 10;12(6)
Metformin protects 5-Fu-induced chemotherapy oral mucositis by reducing endoplasmic reticulum stress in mice.
Sun H, Zhou Y, Ma R, Zhang J, Shan J, Chen Y, Li X, Shan E
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2022 Jun 1;173:106182
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2022 Jun 1;173:106182
Protective effect of nicorandil against myocardial ischemia/reperfusion injury mediated via IL33/ST2 signaling pathway.
Zheng Y, Li X, Zhang F, Zhao B, Du W, Sun D, Li G
Molecular and cellular biochemistry 2022 Jul;477(7):1921-1929
Molecular and cellular biochemistry 2022 Jul;477(7):1921-1929
Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways.
Ma Y, Xiang S, Jiang W, Kong L, Tan Z, Liang Z, Yuan Z, Yi J, Zhu L
Journal of food biochemistry 2022 Jul;46(7):e14118
Journal of food biochemistry 2022 Jul;46(7):e14118
Melatonin improves bisphenol A-induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK-BLV cells.
Song D, Liu Y, Yao Y, Liu F, Tao W, Zhou X, Li R, Zhang X, Li X
Environmental toxicology 2022 Jul;37(7):1551-1562
Environmental toxicology 2022 Jul;37(7):1551-1562
MicroRNA profiling reveals miR-145-5p inhibits goat myoblast differentiation by targeting the coding domain sequence of USP13.
Zhang Z, Deng K, Kang Z, Wang F, Fan Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22370
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22370
Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway.
Zhu D, Wang Z, Zhang G, Ma C, Qiu X, Wang Y, Liu M, Guo X, Chen H, Deng Q, Kang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22369
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22369
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.
Zhong H, Zhou Z, Guo L, Liu FS, Wang X, Li J, Lv GH, Zou MX
Translational research : the journal of laboratory and clinical medicine 2022 Jul;245:99-116
Translational research : the journal of laboratory and clinical medicine 2022 Jul;245:99-116
Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β-catenin signaling pathway.
Zhao Y, Yu J, Ping F, Xu L, Li W, Zhang H, Li Y
Experimental and therapeutic medicine 2022 Jul;24(1):439
Experimental and therapeutic medicine 2022 Jul;24(1):439
Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice.
Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y, Xia Y
Journal of molecular and cellular cardiology 2022 Jul;168:70-82
Journal of molecular and cellular cardiology 2022 Jul;168:70-82
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Li C, Jiang S, Wang H, Wang Y, Han Y, Jiang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Luo P, Huang Q, Chen S, Wang Y, Dou H
International immunopharmacology 2022 Jul;108:108864
International immunopharmacology 2022 Jul;108:108864
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Zhou D, Wang Y, Gui Y, Fu H, Zhou S, Wang Y, Bastacky SI, Stolz DB, Liu Y
Kidney international 2022 Jul;102(1):96-107
Kidney international 2022 Jul;102(1):96-107
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
Liu Q, Fu C, Yang H, Zhou C, Kang J, Chen L, Kong Z, Tan Z, Tang S
Food science & nutrition 2022 Jul;10(7):2400-2407
Food science & nutrition 2022 Jul;10(7):2400-2407
Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway.
Huang Q, Zhang C, Dong S, Han J, Qu S, Xie T, Zhao H, Shi Y
Chinese medicine 2022 Jul 6;17(1):83
Chinese medicine 2022 Jul 6;17(1):83
Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim.
Bao HJ, Chen X, Liu X, Wu W, Li QH, Xian JY, Zhao Y, Chen S
Cell death discovery 2022 Jul 5;8(1):309
Cell death discovery 2022 Jul 5;8(1):309
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Song S, Shi C, Bian Y, Yang Z, Mu L, Wu H, Duan H, Shi Y
Cell death & disease 2022 Jul 30;13(7):663
Cell death & disease 2022 Jul 30;13(7):663
Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.
Dai C, Zhang Q, Shen L, Sharma G, Jiang H, Wang Z, Shen J
Antioxidants (Basel, Switzerland) 2022 Jul 30;11(8)
Antioxidants (Basel, Switzerland) 2022 Jul 30;11(8)
Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells.
Lee W, Song G, Bae H
Marine drugs 2022 Jul 25;20(8)
Marine drugs 2022 Jul 25;20(8)
Revealing the mechanism of Jiegeng decoction attenuates bleomycin-induced pulmonary fibrosis via PI3K/Akt signaling pathway based on lipidomics and transcriptomics.
Xu Y, Wang X, Han D, Wang J, Luo Z, Jin T, Shi C, Zhou X, Lin L, Shan J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154207
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154207
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN.
Liang W, Chen Y, Liu H, Zhao H, Luo T, Tang H, Zhou X, Jiang E, Shao Z, Liu K, Shang Z
International journal of oral science 2022 Jul 19;14(1):36
International journal of oral science 2022 Jul 19;14(1):36
SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism.
Cai G, Ge Z, Xu Y, Cai L, Sun P, Huang G
Scientific reports 2022 Jul 16;12(1):12208
Scientific reports 2022 Jul 16;12(1):12208
Tiao-bu-fei-shen formula promotes downregulation of the caveolin 1-p38 mapk signaling pathway in COPD - Associated tracheobronchomalacia cell model.
Zhou P, Yu W, Zhang C, Chen K, Tang W, Li X, Liu Z, Xia Q
Journal of ethnopharmacology 2022 Jul 15;293:115256
Journal of ethnopharmacology 2022 Jul 15;293:115256
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
Guo T, You K, Chen X, Sun Y, Wu Y, Wu P, Jiang Y
Cell death discovery 2022 Jul 14;8(1):320
Cell death discovery 2022 Jul 14;8(1):320
Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells.
Kalın ŞN, Altay A, Budak H
Chemico-biological interactions 2022 Jul 1;361:109984
Chemico-biological interactions 2022 Jul 1;361:109984
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer.
Li RY, Zheng ZY, Li ZM, Heng JH, Zheng YQ, Deng DX, Xu XE, Liao LD, Lin W, Xu HY, Huang HC, Li EM, Xu LY
Chemico-biological interactions 2022 Jul 1;361:109967
Chemico-biological interactions 2022 Jul 1;361:109967
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Wang Z, Liu D, Yan Q, Liu F, Zhan M, Qi S, Fang Q, Yao L, Wang W, Zhang R, Du J, Chen L
Transplantation 2022 Jul 1;106(7):1351-1364
Transplantation 2022 Jul 1;106(7):1351-1364
Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling.
Zhou X, Wang W, Li Z, Chen L, Wen C, Ruan Q, Xu Z, Liu R, Xu J, Bai Y, Deng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153861
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Su D, Liao L, Zeng Q, Liao Z, Liu Y, Jin C, Zhu G, Chen C, Yang M, Ai Z, Song Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Antitumor activity of Koningic acid in thyroid cancer by inhibiting cellular glycolysis.
Jing C, Li Y, Gao Z, Wang R
Endocrine 2022 Jan;75(1):169-177
Endocrine 2022 Jan;75(1):169-177
BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury.
He X, Huang Y, Liu Y, Zhang X, Yue P, Ma X, Miao Z, Long X, Yang Y, Wan X, Lei J, Shu K, Lei T, Gan C, Zhang H
International journal of molecular medicine 2022 Jan;49(1)
International journal of molecular medicine 2022 Jan;49(1)
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142
Cell and tissue research 2022 Jan;387(1):131-142
Circular RNA circUSP13 sponges miR-29c to promote differentiation and inhibit apoptosis of goat myoblasts by targeting IGF1.
Zhang Z, Fan Y, Deng K, Liang Y, Zhang G, Gao X, El-Samahy MA, Zhang Y, Deng M, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22097
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22097
TRIM59 promotes osteosarcoma progression via activation of STAT3.
Xu G, Ma Z, Yang F, Bai Y, Li J, Luo W, Zhong J
Human cell 2022 Jan;35(1):250-259
Human cell 2022 Jan;35(1):250-259
Molecular Mechanism of Aluminum-Induced Oxidative Damage and Apoptosis in Rat Cardiomyocytes.
Zhou L, He M, Li X, Lin E, Wang Y, Wei H, Wei X
Biological trace element research 2022 Jan;200(1):308-317
Biological trace element research 2022 Jan;200(1):308-317
Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.
Jiang C, Wang ZN, Kang YC, Chen Y, Lu WX, Ren HJ, Hou BR
Neural regeneration research 2022 Jan;17(1):137-143
Neural regeneration research 2022 Jan;17(1):137-143
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice.
Fan H, Tu T, Zhang X, Yang Q, Liu G, Zhang T, Bao Y, Lu Y, Dong Z, Dong J, Zhao P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112759
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112759
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m(6)A modification.
He Y, Wang W, Xu X, Yang B, Yu X, Wu Y, Wang J
Bone 2022 Jan;154:116182
Bone 2022 Jan;154:116182
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Zhou YH, Tang YZ, Guo LY, Zheng LL, Zhang D, Yang CY, Wang W
Microvascular research 2022 Jan;139:104252
Microvascular research 2022 Jan;139:104252
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Liu X, Yang Y, Song J, Li D, Liu X, Li C, Ma Z, Zhong J, Wang L
Bioengineered 2022 Jan;13(1):1320-1334
Bioengineered 2022 Jan;13(1):1320-1334
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Wang L, Zhang D, Ren Y, Guo S, Li J, Ma S, Yao M, Guan F
Materials today. Bio 2022 Jan;13:100201
Materials today. Bio 2022 Jan;13:100201
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.
Nie BX, Zhao G, Yuan XF, Yu LX, Zhang J, Yuan Y, Liu Y, Hu J, Song E, Zhou YC, Shu J
Journal of chemical neuroanatomy 2022 Jan;119:102053
Journal of chemical neuroanatomy 2022 Jan;119:102053
Inhibition of the proliferation, invasion, migration, and epithelial-mesenchymal transition of prostate cancer cells through the action of ATP1A2 on the TGF-β/Smad pathway.
Zhang B, Zhu Z, Zhang X, Li F, Ding A
Translational andrology and urology 2022 Jan;11(1):53-66
Translational andrology and urology 2022 Jan;11(1):53-66
Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.
Liu F, Zhao Q, Su Y, Lv J, Gai Y, Liu S, Lin H, Wang Y, Wang G
Experimental hematology 2022 Jan;105:39-49
Experimental hematology 2022 Jan;105:39-49
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway.
Du P, Zhang X, Luo K, Li Y, Fu C, Xiao J, Xiao Q
Human & experimental toxicology 2022 Jan-Dec;41:9603271221087146
Human & experimental toxicology 2022 Jan-Dec;41:9603271221087146
Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.
Jin Y, Wang H
Journal of ovarian research 2022 Jan 4;15(1):3
Journal of ovarian research 2022 Jan 4;15(1):3
Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway.
Yang L, Wang Q, Zhao Q, Yang F, Liu T, Huang X, Yan Q, Yang X
Aging 2022 Jan 4;14(1):316-329
Aging 2022 Jan 4;14(1):316-329
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Qiu D, Song S, Wang Y, Bian Y, Wu M, Wu H, Shi Y, Duan H
Journal of translational medicine 2022 Jan 28;20(1):44
Journal of translational medicine 2022 Jan 28;20(1):44
Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
Lin J, Li Q, Jin T, Wang J, Gong Y, Lv Q, Wang M, Chen J, Shang M, Zhao Y, Fu G
Cell death & disease 2022 Jan 27;13(1):90
Cell death & disease 2022 Jan 27;13(1):90
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Chen DK, Shao HY, Yang L, Hu JM
Natural products and bioprospecting 2022 Jan 27;12(1):1
Natural products and bioprospecting 2022 Jan 27;12(1):1
Structural Variability of Lipoarabinomannan Modulates Innate Immune Responses within Infected Alveolar Epithelial Cells.
Liu H, Gui X, Chen S, Fu W, Li X, Xiao T, Hou J, Jiang T
Cells 2022 Jan 21;11(3)
Cells 2022 Jan 21;11(3)
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK/PGC-1α signaling pathway and also induces apoptosis and dysregulated mitophagy in the duck liver.
Zhong G, Hu T, Tang L, Li T, Wu S, Duan X, Pan J, Zhang H, Tang Z, Feng X, Hu L
Ecotoxicology and environmental safety 2022 Jan 15;230:113117
Ecotoxicology and environmental safety 2022 Jan 15;230:113117
Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice.
An N, Li Z, Yan X, Zhao H, Yang Y, Liu R, Yang Y, Gao F, Li B, Liu H, Yuan H
Cell death discovery 2022 Jan 14;8(1):26
Cell death discovery 2022 Jan 14;8(1):26
Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension.
Guo M, Zhang M, Cao X, Fang X, Li K, Qin L, He Y, Zhao J, Xu Y, Liu X, Li X
Respiratory research 2022 Jan 11;23(1):6
Respiratory research 2022 Jan 11;23(1):6
Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.
Zhi W, Li S, Wan Y, Wu F, Hong L
Cancer cell international 2022 Jan 11;22(1):18
Cancer cell international 2022 Jan 11;22(1):18
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
Shen Y, Yang F, Peng H, Zhang G, Zhu F, Xu H, Shi L
Journal of ethnopharmacology 2022 Jan 10;282:114601
Journal of ethnopharmacology 2022 Jan 10;282:114601
Autophagy and apoptosis mediated nano-copper-induced testicular damage.
Chen H, Wang Y, Luo J, Kang M, Hou J, Tang R, Zhao L, Shi F, Ye G, He X, Cui H, Guo H, Li Y, Tang H
Ecotoxicology and environmental safety 2022 Jan 1;229:113039
Ecotoxicology and environmental safety 2022 Jan 1;229:113039
Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke.
Gao ZK, Shen XY, Han Y, Guo YS, Li K, Bi X
Translational neuroscience 2022 Jan 1;13(1):495-505
Translational neuroscience 2022 Jan 1;13(1):495-505
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
Li X, Pan J, Li H, Li G, Liu B, Tang X, Liu X, He Z, Peng Z, Zhang H, Wang L, Li Y, Xiang X, Chai X, Yuan Y, Zheng P, Zhang D
EBioMedicine 2022 Feb;76:103859
EBioMedicine 2022 Feb;76:103859
Artemisia capillaris Thunb. water extract attenuates adriamycin-induced renal injury by regulating apoptosis through the ROS/MAPK axis.
Huang G, Zhu Y, Yong C, Tian F, Liu L, Wu Q, Shu Y, Yao M, Tang C, Wang X, Chen W, Zhou E
Journal of food biochemistry 2022 Feb;46(2):e14065
Journal of food biochemistry 2022 Feb;46(2):e14065
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Bai Y, Wang M, Yang Y, Liu X, Chen Q, Guo Z
Cell biology international 2022 Feb;46(2):192-202
Cell biology international 2022 Feb;46(2):192-202
Simvastatin Improves Outcomes of Endotoxin-induced Coagulopathy by Regulating Intestinal Microenvironment.
Xu M, Luo LL, Du MY, Tang L, Zhou J, Hu Y, Mei H
Current medical science 2022 Feb;42(1):26-38
Current medical science 2022 Feb;42(1):26-38
Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
Chiu HW, Hou YC, Lu CL, Lu KC, Liu WC, Shyu JF, Chang JF, Zheng CM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Feb;37(2):215-225
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Feb;37(2):215-225
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Ayesha M, Majid A, Zhao D, Greenaway FT, Yan N, Liu Q, Liu S, Sun MZ
Journal of advanced research 2022 Feb;36:147-161
Journal of advanced research 2022 Feb;36:147-161
Neuroglobin expression and function in the temporal cortex of bilirubin encephalopathy rats.
Hu JH, Fan P, Zhang LR, Chen CY, Xu J, Huang J, Lu WT, Zhu SJ, Qiu GP, Xu SY, Ran JH, Gan SW
Anatomical record (Hoboken, N.J. : 2007) 2022 Feb;305(2):254-264
Anatomical record (Hoboken, N.J. : 2007) 2022 Feb;305(2):254-264
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Wang N, Huang R, Yang K, He Y, Gao Y, Dong D
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
MiR-181c suppresses triple-negative breast cancer tumorigenesis by targeting MAP4K4.
Xie D, Li S, Wu T, Wang X, Fang L
Pathology, research and practice 2022 Feb;230:153763
Pathology, research and practice 2022 Feb;230:153763
Zinc Protects against Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells.
Xiong Y, Li J, He S
Biological trace element research 2022 Feb;200(2):728-739
Biological trace element research 2022 Feb;200(2):728-739
Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint.
Chu M, An X, Zhang D, Li Q, Dai X, Yu H, Li Z
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119169
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119169
ZFP36 protects against oxygen-glucose deprivation/reoxygenation-induced mitochondrial fragmentation and neuronal apoptosis through inhibiting NOX4-DRP1 pathway.
Guo H, Jiang Y, Gu Z, Ren L, Zhu C, Yu S, Wei R
Brain research bulletin 2022 Feb;179:57-67
Brain research bulletin 2022 Feb;179:57-67
l-Argine regulates the proliferation, apoptosis and endocrine activity by alleviating oxidative stress in sheep endometrial epithelial cells.
Gao X, Li X, Wang Z, Li K, Liang Y, Yao X, Zhang G, Wang F
Theriogenology 2022 Feb;179:187-196
Theriogenology 2022 Feb;179:187-196
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke.
Ma YH, Deng WJ, Luo ZY, Jing J, Pan PW, Yao YB, Fang YB, Teng JF
Neural regeneration research 2022 Feb;17(2):433-439
Neural regeneration research 2022 Feb;17(2):433-439
Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats.
Poasakate A, Maneesai P, Potue P, Bunbupha S, Tong-Un T, Settheetham-Ishida W, Khamseekaew J, Pakdeechote P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112601
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112601
Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways.
Zhao J, Pan B, Zhou X, Wu C, Hao F, Zhang J, Liu L
Bioengineered 2022 Feb;13(2):2992-3006
Bioengineered 2022 Feb;13(2):2992-3006
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis.
Li G, Zong W, Liu L, Wu J, Pang J
Bioengineered 2022 Feb;13(2):2791-2802
Bioengineered 2022 Feb;13(2):2791-2802
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Sun X, Shu Y, Ye G, Wu C, Xu M, Gao R, Huang D, Zhang J
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.
Zhou Y, Zhang J, Li W, Zhang D, Wang Z, Zhai Y, Yu H, Li Z
FEBS open bio 2022 Feb;12(2):379-393
FEBS open bio 2022 Feb;12(2):379-393
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Chen X, Song QL, Ji R, Wang JY, Li ZH, Guo D, Yin TL, Wang SJ, Yang J
Placenta 2022 Feb;118:20-31
Placenta 2022 Feb;118:20-31
3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway.
Zhou H, Mo L, Huang N, Zou C, Li C, Lin M, Zhang B, Wei B, Li P, Si X, Chen J, Li W, Liu X, Hu B
Annals of translational medicine 2022 Feb;10(4):168
Annals of translational medicine 2022 Feb;10(4):168
Anticancer effects of myricetin derivatives in non-small cell lung cancer in vitro and in vivo.
Li M, Zha G, Chen R, Chen X, Sun Q, Jiang H
Pharmacology research & perspectives 2022 Feb;10(1):e00905
Pharmacology research & perspectives 2022 Feb;10(1):e00905
Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia-reperfusion injury are mediated by regulating the PI3K/AKT pathway.
Lu T, Li H, Zhou Y, Wei W, Ding L, Zhan Z, Liu W, Tao J, Xue X
Journal of neuroinflammation 2022 Feb 7;19(1):37
Journal of neuroinflammation 2022 Feb 7;19(1):37
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression.
Liu XM, Zhang Z, Zhong J, Li N, Wang T, Wang L, Zhang Q
European journal of pharmacology 2022 Feb 5;916:174719
European journal of pharmacology 2022 Feb 5;916:174719
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K
European journal of medicinal chemistry 2022 Feb 5;229:114081
European journal of medicinal chemistry 2022 Feb 5;229:114081
miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression.
Liu BJ, Li FF, Xie YX, Fan CY, Liu WJ, Qiu JG, Jiang BH
International journal of molecular sciences 2022 Feb 4;23(3)
International journal of molecular sciences 2022 Feb 4;23(3)
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Yu J, Guo Y, Gu Y, Li F, Song H, Nian R, Fan X, Liu W
International journal of biological macromolecules 2022 Feb 28;199:298-306
International journal of biological macromolecules 2022 Feb 28;199:298-306
Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway.
Chueakwon P, Jatooratthawichot P, Talabnin K, Ketudat Cairns JR, Talabnin C
Life (Basel, Switzerland) 2022 Feb 28;12(3)
Life (Basel, Switzerland) 2022 Feb 28;12(3)
Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition - More Than Just ROS-inhibition.
Sha Z, Yang Y, Liu R, Bao H, Song S, Dong J, Guo M, Zhao Y, Liu H, Ding G
Journal of clinical and translational hepatology 2022 Feb 28;10(1):42-52
Journal of clinical and translational hepatology 2022 Feb 28;10(1):42-52
FTO protects human granulosa cells from chemotherapy-induced cytotoxicity.
Wang R, Wang W, Wang L, Yuan L, Cheng F, Guan X, Zheng N, Yang X
Reproductive biology and endocrinology : RB&E 2022 Feb 26;20(1):39
Reproductive biology and endocrinology : RB&E 2022 Feb 26;20(1):39
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Wang Q, Chen W, Zhang B, Gao Z, Zhang Q, Deng H, Han L, Shen XL
Chemico-biological interactions 2022 Feb 25;354:109844
Chemico-biological interactions 2022 Feb 25;354:109844
Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways.
Cheng Z, Liu Y, Ma M, Sun S, Ma Z, Wang Y, Yu L, Qian X, Sun L, Zhang X, Liu Y, Wang Y
Molecular medicine (Cambridge, Mass.) 2022 Feb 19;28(1):21
Molecular medicine (Cambridge, Mass.) 2022 Feb 19;28(1):21
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy.
Liu Y, Li Q, Gu M, Lu D, Xiong X, Zhang Z, Pan Y, Liao Y, Ding Q, Gong W, Chen DS, Guan M, Wu J, Tian Z, Deng H, Gu L, Hong X, Xiao Y
Journal of medicinal chemistry 2022 Feb 10;65(3):2225-2237
Journal of medicinal chemistry 2022 Feb 10;65(3):2225-2237
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Ni L, Xiao J, Zhang D, Shao Z, Huang C, Wang S, Wu Y, Tian N, Sun L, Wu A, Zhou Y, Wang X, Zhang X
Cell death & disease 2022 Feb 10;13(2):140
Cell death & disease 2022 Feb 10;13(2):140
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Qin J, Sun X, Ma Y, Cheng Y, Ma Q, Jing W, Qu S, Liu L
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy.
Hong T, Zhou Y, Peng L, Wu X, Li Y, Li Y, Zhao Y
Neuroscience 2022 Feb 1;482:30-42
Neuroscience 2022 Feb 1;482:30-42
Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model.
Ma X, Yu X, Min J, Chen X, Liu R, Cui X, Cheng J, Xie M, Diel P, Hu X
Toxicology letters 2022 Feb 1;355:106-115
Toxicology letters 2022 Feb 1;355:106-115
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
Xu M, Ren L, Fan J, Huang L, Zhou L, Li X, Ye X
Life sciences 2022 Feb 1;290:120266
Life sciences 2022 Feb 1;290:120266
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Han QJ, Han G, Peng J, Tang Z
Free radical biology & medicine 2022 Feb 1;179:416-417
Free radical biology & medicine 2022 Feb 1;179:416-417
Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy.
Dong F, Jiang S, Tang C, Wang X, Ren X, Wei Q, Tian J, Hu W, Guo J, Fu X, Liu L, Patzak A, Persson PB, Gao F, Lai EY, Zhao L
Free radical biology & medicine 2022 Feb 1;179:288-300
Free radical biology & medicine 2022 Feb 1;179:288-300
QiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy.
Lv S, Zhang W, Yuan P, Lu C, Dong J, Zhang J
Pharmaceutical biology 2022 Dec;60(1):722-728
Pharmaceutical biology 2022 Dec;60(1):722-728
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.
Bian Y, Xue M, Guo X, Jiang W, Zhao Y, Zhang Z, Wang X, Hu Y, Zhang Q, Dun W, Zhang L
Pharmaceutical biology 2022 Dec;60(1):1801-1811
Pharmaceutical biology 2022 Dec;60(1):1801-1811
Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.
Jiao Y, Xin M, Xu J, Xiang X, Li X, Jiang J, Jia X
Pharmaceutical biology 2022 Dec;60(1):1781-1789
Pharmaceutical biology 2022 Dec;60(1):1781-1789
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Lu QJ, Li JY, Lin HX, Cai YS, Liu CS, Fu LP, Liu G, Yuan LX
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro.
Yang Y, Ren ZZ, Wei WJ, He ZL, Deng YL, Wang Z, Fan YC, Zhou J, Jiang LH
Pharmaceutical biology 2022 Dec;60(1):1566-1577
Pharmaceutical biology 2022 Dec;60(1):1566-1577
Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway.
Meng F, Chen Q, Gu S, Cui R, Ma Q, Cao R, Zhao M
Renal failure 2022 Dec;44(1):672-681
Renal failure 2022 Dec;44(1):672-681
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
He S, Zhou M, Zheng H, Wang Y, Wu S, Gao Y, Chen J
Renal failure 2022 Dec;44(1):171-183
Renal failure 2022 Dec;44(1):171-183
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Zhang Q, Gao Y, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X, Li Y, Wu D
Oncogene 2022 Dec;41(49):5238-5252
Oncogene 2022 Dec;41(49):5238-5252
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.
Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y
Metabolic brain disease 2022 Dec;37(8):2965-2978
Metabolic brain disease 2022 Dec;37(8):2965-2978
MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX.
Tu Y, Chen Q, Guo W, Xiang P, Huang H, Fei H, Chen L, Yang Y, Peng Z, Gu C, Tan X, Liu X, Lu Y, Chen R, Wang H, Luo Y, Yang J
Experimental neurology 2022 Dec;358:114212
Experimental neurology 2022 Dec;358:114212
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Zhou X, Song L, Cong R, Luan J, Zhou X, Wang Y, Yao L, Zhang X, Ren X, Zhang T, Yu M, Song N
Chemosphere 2022 Dec;308(Pt 3):136486
Chemosphere 2022 Dec;308(Pt 3):136486
Hesperidin partly ameliorates the decabromodiphenyl ether-induced reproductive toxicity in pubertal mice.
Li S, Che S, Chen S, Ruan Z, Zhang L
Environmental science and pollution research international 2022 Dec;29(60):90391-90403
Environmental science and pollution research international 2022 Dec;29(60):90391-90403
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.
Li QR, Xu HZ, Xiao RC, Liu Y, Tang JM, Li J, Yu TT, Liu B, Li LG, Wang MF, Han N, Xu YH, Wang C, Komatsu N, Zhao L, Peng XC, Li TF, Chen X
Drug delivery 2022 Dec;29(1):937-949
Drug delivery 2022 Dec;29(1):937-949
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity.
Lu R, Yu RJ, Yang C, Wang Q, Xuan Y, Wang Z, He Z, Xu Y, Kou L, Zhao YZ, Yao Q, Xu SH
Drug delivery 2022 Dec;29(1):3256-3269
Drug delivery 2022 Dec;29(1):3256-3269
Sevelamer arsenite nanoparticle as a Pi-responsive drug carrier and embolic agent for chemoembolization.
Bi QC, Tang JJ, Zhao J, Lv YF, Deng ZQ, Chen H, Xu YH, Xie CS, Liang QR, Luo RG, Tang Q
Drug delivery 2022 Dec;29(1):1447-1456
Drug delivery 2022 Dec;29(1):1447-1456
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.
Liu S, Qiao X, Wu S, Gai Y, Su Y, Edwards H, Wang Y, Lin H, Taub JW, Wang G, Ge Y
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Xiao Q, Liu Y, Zhang X, Liu Z, Xiao J, Ye Q, Fu B
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Alfalfa saponins inhibit oxidative stress-induced cell apoptosis through the MAPK signaling pathway.
Cui Y, Li F, Zhu X, Xu J, Muhammad A, Chen Y, Li D, Liu B, Wang C, Wang Z, Ma S, Liu X, Shi Y
Redox report : communications in free radical research 2022 Dec;27(1):1-8
Redox report : communications in free radical research 2022 Dec;27(1):1-8
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
Guo W, Wang X, Liu F, Chen S, Wang S, Zhang Q, Yuan L, Du S
Molecular medicine reports 2022 Dec;26(6)
Molecular medicine reports 2022 Dec;26(6)
FBXL6 depletion restrains clear cell renal cell carcinoma progression.
Yu Y, Yao W, Wang T, Xue W, Meng Y, Cai L, Jian W, Yu Y, Zhang C
Translational oncology 2022 Dec;26:101550
Translational oncology 2022 Dec;26:101550
Para‑hydroxybenzaldehyde against transient focal cerebral ischemia in rats via mitochondrial preservation.
Xiao T, Yang L, Chen P, Duan X
Experimental and therapeutic medicine 2022 Dec;24(6):716
Experimental and therapeutic medicine 2022 Dec;24(6):716
Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control.
Chai N, Zheng H, Zhang H, Li L, Yu X, Wang L, Bi X, Yang L, Niu T, Liu X, Zhao Y, Dong L
Iranian journal of pharmaceutical research : IJPR 2022 Dec;21(1):e133776
Iranian journal of pharmaceutical research : IJPR 2022 Dec;21(1):e133776
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress.
Chen S, Li Y, Fu S, Li Y, Wang C, Sun P, Li H, Tian J, Du GQ
Biochemical pharmacology 2022 Dec;206:115265
Biochemical pharmacology 2022 Dec;206:115265
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Fu Z, Du H, Meng S, Yao M, Zhao P, Li X, Zheng X, Yuan Z, Yang H, Cai K, Dai L
Materials today. Bio 2022 Dec;16:100449
Materials today. Bio 2022 Dec;16:100449
The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
Liu L, Yuan Y, Zhou Y, Yao L, Li J, Chen F
Molecular immunology 2022 Dec;152:67-77
Molecular immunology 2022 Dec;152:67-77
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Jie W, Rui-Fen Z, Zhong-Xiang H, Yan W, Wei-Na L, Yong-Ping M, Jing S, Jing-Yi C, Wan-Hong L, Xiao-Hua H, Zhi L, Yan S
Virulence 2022 Dec;13(1):342-354
Virulence 2022 Dec;13(1):342-354
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.
Chen J, Lin X, He J, Liu D, He L, Zhang M, Luan H, Hu Y, Tao C, Wang Q
Clinical and translational medicine 2022 Dec;12(12):e1148
Clinical and translational medicine 2022 Dec;12(12):e1148
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress.
Li J, Li J, Fang H, Yang H, Wu T, Shi X, Pang C
International immunopharmacology 2022 Dec;113(Pt A):109185
International immunopharmacology 2022 Dec;113(Pt A):109185
Effects of betaine on viability, apoptosis, function protein expression and oxidative status in heat-stressed IEC-6 cells.
Sun S, Yin Q, Li B, Deng Y, Li J, Xiong Y, Shaojun H
Journal of thermal biology 2022 Dec;110:103348
Journal of thermal biology 2022 Dec;110:103348
USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway.
Zhou Y, Zhao Y, Ma W, Zhang L, Jiang Y, Dong W
Discover oncology 2022 Dec 8;13(1):136
Discover oncology 2022 Dec 8;13(1):136
Exosome-transmitted S100A4 induces immunosuppression and non-small cell lung cancer development by activating STAT3.
Wu X, Zhang H, Jiang G, Peng M, Li C, Lu J, Jiang S, Yang X, Jiang Y
Clinical and experimental immunology 2022 Dec 31;210(3):309-320
Clinical and experimental immunology 2022 Dec 31;210(3):309-320
Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1.
Liu X, Cao N, Liu X, Deng Y, Xin Y, Fu R, Xin X, Hou Y, Yu W
International journal of molecular sciences 2022 Dec 26;24(1)
International journal of molecular sciences 2022 Dec 26;24(1)
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Li Y, Miao H, Wei W, Tian J, Chen J
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.
Wang J, Li G, Lin M, Lin S, Wu L
BMC molecular and cell biology 2022 Dec 23;23(1):60
BMC molecular and cell biology 2022 Dec 23;23(1):60
Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury.
Zhang R, Chen M, Deng Z, Kong L, Shen B, Zhang L
Pharmaceutics 2022 Dec 23;15(1)
Pharmaceutics 2022 Dec 23;15(1)
LncRNA HIF1A-AS1 Regulates the Cellular Function of HUVECs by Globally Regulating mRNA and miRNA Expression.
Gong Z, Yang J, Dong J, Li H, Wang B, Du K, Zhang C, Chen L
Frontiers in bioscience (Landmark edition) 2022 Dec 21;27(12):330
Frontiers in bioscience (Landmark edition) 2022 Dec 21;27(12):330
Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?
Huang Z, Tang Z, Guan H, Leung W, Wang L, Xia H, Zhang W
Biomedicines 2022 Dec 19;10(12)
Biomedicines 2022 Dec 19;10(12)
Long noncoding RNA HOTAIR facilitates pulmonary vascular endothelial cell apoptosis via DNMT1 mediated hypermethylation of Bcl-2 promoter in COPD.
Dai Z, Liu X, Zeng H, Chen Y
Respiratory research 2022 Dec 17;23(1):356
Respiratory research 2022 Dec 17;23(1):356
Fluid shear stress-induced down-regulation of miR-146a-5p inhibits osteoblast apoptosis via targeting SMAD4.
Liu X, Zhang K, Wang L, Geng B, Liu Z, Yi Q, Xia Y
Physiological research 2022 Dec 16;71(6):835-848
Physiological research 2022 Dec 16;71(6):835-848
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2022 Dec 16;17(24):e202200317
ChemMedChem 2022 Dec 16;17(24):e202200317
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Qi Y, Xue HL, Zheng YJ, Yin YF, Xu WL, Xu JH, Wu M, Chen L, Xu LX
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
HIV-1 gp120 Protein Activates Cyclin-Dependent Kinase 1, a Possible Link to Central Nervous System Cell Death.
Saro A, Gao Z, Kambey PA, Li M, Huang J
Viruses 2022 Dec 15;14(12)
Viruses 2022 Dec 15;14(12)
Fecal Microbiota Transplantation Alleviated Cerebral Ischemia Reperfusion Injury in Obese Rats.
Xie T, Yang R, Zhang X, Shen X, Yu L, Liao J, Bao T, Fang Q
The Tohoku journal of experimental medicine 2022 Dec 14;259(1):49-55
The Tohoku journal of experimental medicine 2022 Dec 14;259(1):49-55
Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts.
Li S, Yang J, Sun J, Chen M
Cells 2022 Dec 12;11(24)
Cells 2022 Dec 12;11(24)
Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice.
Xing F, Wang M, Ding Z, Zhang J, Ding S, Shi L, Xie Q, Ahmad MJ, Wei Z, Tang L, Liang D, Cao Y, Liu Y
Journal of clinical medicine 2022 Dec 12;11(24)
Journal of clinical medicine 2022 Dec 12;11(24)
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Xue Y, Luo M, Hu X, Li X, Shen J, Zhu W, Huang L, Hu Y, Guo Y, Liu L, Wang L, Luo S
Communications biology 2022 Dec 1;5(1):1316
Communications biology 2022 Dec 1;5(1):1316
Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma.
Kalın ŞN, Altay A, Budak H
Life sciences 2022 Dec 1;310:121093
Life sciences 2022 Dec 1;310:121093
Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis.
Chen Q, Han H, Lin F, Yang L, Feng L, Lai X, Wen Z, Yang M, Wang C, Ma Y, Yin T, Lu G, Lin H, Qi J, Yang Y
Life sciences 2022 Dec 1;310:121077
Life sciences 2022 Dec 1;310:121077
GYY4137 ameliorates sepsis-induced cardiomyopathy via NLRP3 pathway.
Zhou T, Qian H, Zheng N, Lu Q, Han Y
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166497
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166497
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y
Redox biology 2022 Aug;54:102390
Redox biology 2022 Aug;54:102390
Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function.
Li J, Bu Y, Li B, Zhang H, Guo J, Hu J, Zhang Y
Journal of molecular histology 2022 Aug;53(4):713-727
Journal of molecular histology 2022 Aug;53(4):713-727
MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.
Li T, Chen Q, Dai J, Huang Z, Luo Y, Mou T, Pu J, Yang H, Wei X, Wu Z
Molecular biology reports 2022 Aug;49(8):7575-7585
Molecular biology reports 2022 Aug;49(8):7575-7585
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.
Chen S, Huang Y, Su H, Zhu W, Wei Y, Long Y, Shi Y, Wei J
Inflammation 2022 Aug;45(4):1780-1799
Inflammation 2022 Aug;45(4):1780-1799
TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
Liu C, Li Y, Wang X
Inflammation 2022 Aug;45(4):1520-1533
Inflammation 2022 Aug;45(4):1520-1533
Downstream Neighbor of Son Overexpression is Associated With Breast Cancer Progression and a Poor Prognosis.
Qi Y, Wu H, Liu C, Zheng D, Yan C, Hu W, Zhang X, Dai X
Journal of breast cancer 2022 Aug;25(4):327-343
Journal of breast cancer 2022 Aug;25(4):327-343
Nonylphenol inhibited HIF-1alpha regulated aerobic glycolysis and induced ROS mediated apoptosis in rat Sertoli cells.
Jiang Q, Di Q, Shan D, Xu Q
Ecotoxicology and environmental safety 2022 Aug;241:113822
Ecotoxicology and environmental safety 2022 Aug;241:113822
Effect of low energy shock wave on testicular microenvironment homeostasis in rats.
Xing J, Yu G, Xiang Y, Xu H, Liu Z, Bai Z
Ecotoxicology and environmental safety 2022 Aug;241:113710
Ecotoxicology and environmental safety 2022 Aug;241:113710
miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis.
Zhao J, Ma X, Xu H
Oncology letters 2022 Aug;24(2):289
Oncology letters 2022 Aug;24(2):289
Identification and verification of the role of crucial genes through which methionine restriction inhibits the progression of colon cancer cells.
Zhou L, Chen Z, Liu C
Oncology letters 2022 Aug;24(2):274
Oncology letters 2022 Aug;24(2):274
Cyclometalated iridium(III) dithioformic acid complexes as mitochondria-targeted imaging and anticancer agents.
Wu Y, Liu J, Shao M, Zhang P, Song S, Yang G, Liu X, Liu Z
Journal of inorganic biochemistry 2022 Aug;233:111855
Journal of inorganic biochemistry 2022 Aug;233:111855
Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism.
Zhang B, Fu R, Duan Z, Shen S, Zhu C, Fan D
Biochemical pharmacology 2022 Aug;202:115101
Biochemical pharmacology 2022 Aug;202:115101
Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways.
Li QM, Yang XR, Zha XQ, Pan LH, Zang DD, Zhang FY, Luo JP
Chemistry & biodiversity 2022 Aug;19(8):e202200471
Chemistry & biodiversity 2022 Aug;19(8):e202200471
Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells.
Ali I, Li C, Kuang M, Shah AU, Shafiq M, Ahmad MA, Abdalmegeed D, Li L, Wang G
Molecular immunology 2022 Aug;148:54-67
Molecular immunology 2022 Aug;148:54-67
CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-κB pathway in gastric cancer cells.
Xiu T, Guo Q, Jing F, Shi Y, Jing F
Translational cancer research 2022 Aug;11(8):2487-2500
Translational cancer research 2022 Aug;11(8):2487-2500
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H(2)O(2)-induced cardiomyocyte injury.
Zhang RH, Yang D, Liao XM, Zhang H, Chen GQ, Zhang WL, Wang YC, Wang C, Liao SG, Zhou M, Wang YL, Li YJ
European journal of medicinal chemistry 2022 Aug 5;238:114469
European journal of medicinal chemistry 2022 Aug 5;238:114469
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Wang C, Chen X, Liu X, Lu D, Li S, Qu L, Yin F, Luo H, Zhang Y, Luo Z, Cui N, Kong L, Wang X
European journal of medicinal chemistry 2022 Aug 5;238:114462
European journal of medicinal chemistry 2022 Aug 5;238:114462
Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.
Huang H, Ding X, Xing D, Lin J, Li Z, Lin J
Molecules (Basel, Switzerland) 2022 Aug 31;27(17)
Molecules (Basel, Switzerland) 2022 Aug 31;27(17)
Myocardium-Targeted Micelle Nanomedicine That Salvages the Heart from Ischemia/Reperfusion Injury.
Yang L, Peng J, Shi A, Wang X, Li J, Su Y, Yin K, Zhao L, Zhao Y
ACS applied materials & interfaces 2022 Aug 31;14(34):38562-38574
ACS applied materials & interfaces 2022 Aug 31;14(34):38562-38574
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy.
Wang N, Li Y, He F, Liu S, Liu Y, Peng J, Liu J, Yu C, Wang S
Pharmaceuticals (Basel, Switzerland) 2022 Aug 29;15(9)
Pharmaceuticals (Basel, Switzerland) 2022 Aug 29;15(9)
Investigation of the effects of high cervical spinal cord electrical stimulation on improving neurological dysfunction and its potential mechanism in rats with traumatic brain injury.
Zhao PC, Huang ZS, Xu SN, Deng PC, Qian F, Shi J, Zhang YM
Neuroreport 2022 Aug 2;33(12):509-517
Neuroreport 2022 Aug 2;33(12):509-517
Lianhuaqingwen alleviates p53-mediated apoptosis in alveolar epithelial cells to prevent LPS-induced ALI.
Yang R, Yang H, Li W, Yue F, Chen H, Hao Y, Hu K
The Journal of pharmacy and pharmacology 2022 Aug 19;74(8):1117-1124
The Journal of pharmacy and pharmacology 2022 Aug 19;74(8):1117-1124
METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner.
Li J, Yao H, Huang J, Li C, Zhang Y, Xu R, Wang Z, Long Z, Tang J, Wang L
Cell death & disease 2022 Aug 19;13(8):723
Cell death & disease 2022 Aug 19;13(8):723
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy.
Sun Y, Guan X, Zhang T, Li Y, Shi H, Chitakunye AT, Hong H, Zhang S, Zhu Q, Cai L
Medical oncology (Northwood, London, England) 2022 Aug 16;39(11):159
Medical oncology (Northwood, London, England) 2022 Aug 16;39(11):159
Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway.
Liu J, Li B, Liu J, Qiu F, Diao Y, Lei Y, Liu J, Zhang W
Molecules (Basel, Switzerland) 2022 Aug 16;27(16)
Molecules (Basel, Switzerland) 2022 Aug 16;27(16)
Covalent Organic Framework (COF): A Drug and Carrier to Attenuate Retinal Ganglion Cells Death in an Acute Glaucoma Mouse Model.
Yao K, Liang X, Zhang G, Rong Y, Zhang Q, Liao Q, Zhang H, Xi K, Wang J
Polymers 2022 Aug 10;14(16)
Polymers 2022 Aug 10;14(16)
Sparstolonin B inhibits pancreatic adenocarcinoma through the NF-κB signaling pathway.
Lyu Y, Duan B, Liu Z, Yang F, Chen C, Jiang X, Liu X
Experimental cell research 2022 Aug 1;417(1):113214
Experimental cell research 2022 Aug 1;417(1):113214
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Zhu J, Liu L, Ma J, Fu Q, Zheng Z, Du E, Xu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Acetyl CoA synthase 2 potentiates ATG5-induced autophagy against neuronal apoptosis after subarachnoid hemorrhage.
He W, Zhou X, Wu Q, Zhou L, Zhang Z, Zhang R, Deng C, Zhang X
Journal of molecular histology 2022 Apr;53(2):511-521
Journal of molecular histology 2022 Apr;53(2):511-521
Melatonin Attenuates Ropivacaine-Induced Apoptosis by Inhibiting Excessive Mitophagy Through the Parkin/PINK1 Pathway in PC12 and HT22 Cells.
Zeng L, He J, Liu C, Zhang F, Zhang Z, Chen H, Wang Q, Ding X, Luo H
Inflammation 2022 Apr;45(2):725-738
Inflammation 2022 Apr;45(2):725-738
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
Jin X, Yu W, Ye P
Environmental toxicology 2022 Apr;37(4):730-740
Environmental toxicology 2022 Apr;37(4):730-740
SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
Zhang Y, Chen Q, Chen D, Zhao W, Wang H, Yang M, Xiang Z, Yuan H
CNS neuroscience & therapeutics 2022 Apr;28(4):566-579
CNS neuroscience & therapeutics 2022 Apr;28(4):566-579
Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Xuan L, Hu JH, Bi R, Liu SQ, Wang CX
Chinese journal of integrative medicine 2022 Apr;28(4):349-356
Chinese journal of integrative medicine 2022 Apr;28(4):349-356
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer.
Yu TT, Peng XC, Wang MF, Han N, Xu HZ, Li QR, Li LG, Xu X, Ma QL, Liu B, Wang J, Zhao L, Chen X, Li TF
Journal of cancer research and clinical oncology 2022 Apr;148(4):867-879
Journal of cancer research and clinical oncology 2022 Apr;148(4):867-879
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier.
Zhan L, Pu J, Zheng J, Hang S, Pang L, Dai M, Ji C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Apr;148:112741
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Apr;148:112741
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Liu W, Feng Y, Wang X, Ding J, Li H, Guan H, Chen Z
Bioengineered 2022 Apr;13(4):8850-8865
Bioengineered 2022 Apr;13(4):8850-8865
DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling.
Feng Q, Cheng M, Jin J, Zhang S, Bai Y, Xu J
Acta histochemica 2022 Apr;124(3):151874
Acta histochemica 2022 Apr;124(3):151874
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway.
Chen L, Qing J, Xiao Y, Huang X, Chi Y, Chen Z
BMC cancer 2022 Apr 7;22(1):370
BMC cancer 2022 Apr 7;22(1):370
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
Han Y, Li C, Zhang P, Yang X, Min J, Wu Q, Xie Y, Jin D, Wang Z, Shao F, Quan H
European journal of pharmacology 2022 Apr 5;920:174811
European journal of pharmacology 2022 Apr 5;920:174811
GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway.
Zhang W, Sun W, Gu X, Miao C, Feng L, Shen Q, Liu X, Zhang X
Cell death discovery 2022 Apr 4;8(1):162
Cell death discovery 2022 Apr 4;8(1):162
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
Lu H, Yin H, Qu L, Ma X, Fu R, Fan D
Food & function 2022 Apr 4;13(7):3793-3811
Food & function 2022 Apr 4;13(7):3793-3811
Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer.
Jiang H, Cui J, Chu H, Xu T, Xie M, Jing X, Xu J, Zhou J, Shu Y
Cell death discovery 2022 Apr 29;8(1):235
Cell death discovery 2022 Apr 29;8(1):235
Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.
Yao H, Guo W, Suo L, Li G, Wang Y, Chen Y, Sun Y, Ding R
Behavioural brain research 2022 Apr 29;424:113813
Behavioural brain research 2022 Apr 29;424:113813
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J, Zou Y
International journal of molecular sciences 2022 Apr 28;23(9)
International journal of molecular sciences 2022 Apr 28;23(9)
Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.
Wang T, Chen Z, Chen H, Yu X, Wang L, Liu X
Journal of ethnopharmacology 2022 Apr 24;288:115020
Journal of ethnopharmacology 2022 Apr 24;288:115020
Network pharmacology analysis and experimental validation to explore the mechanism of Shenlian extract on myocardial ischemia.
Li JJ, Wang CM, Wang YJ, Yang Q, Cai WY, Li YJ, Song M, Zang YL, Cui XH, Li Q, Chen Y, Weng XG, Zhu XX
Journal of ethnopharmacology 2022 Apr 24;288:114973
Journal of ethnopharmacology 2022 Apr 24;288:114973
Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
Chen L, Chen Y, Ding W, Zhan T, Zhu J, Zhang L, Wang H, Shen B, Wang Y
Cells 2022 Apr 2;11(7)
Cells 2022 Apr 2;11(7)
The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.
Xiao W, Su J, Gao X, Yang H, Weng R, Ni W, Gu Y
Microbiome 2022 Apr 17;10(1):62
Microbiome 2022 Apr 17;10(1):62
Nicotinamide mononucleotide alleviates heat stress-induced oxidative stress and apoptosis in BMECs through reducing mitochondrial damage and endoplasmic reticulum stress.
Zeng HF, Xu J, Wang XL, Li SJ, Han ZY
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
Ecotoxicology and environmental safety 2022 Apr 15;235:113441
Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice.
Shen Y, Guo J, Zhang X, Wang X, Zhu S, Chen D, Xiong W, Lu G, Liu X, Dai C, Gong F, Wang Y, Lin G, Wang Z, Xu W
Human reproduction (Oxford, England) 2022 Apr 1;37(4):859-872
Human reproduction (Oxford, England) 2022 Apr 1;37(4):859-872
NaAsO(2) decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway.
Ran S, Gao X, Ma M, Zhang J, Li S, Zhang M, Li S
Ecotoxicology and environmental safety 2022 Apr 1;234:113380
Ecotoxicology and environmental safety 2022 Apr 1;234:113380
Comprehensive analysis of abnormal expression, prognostic value and oncogenic role of the hub gene FN1 in pancreatic ductal adenocarcinoma via bioinformatic analysis and in vitro experiments.
Lei X, Chen G, Li J, Wen W, Gong J, Fu J
PeerJ 2021;9:e12141
PeerJ 2021;9:e12141
Inhibitory effect and mechanism of action (MOA) of hirsutine on the proliferation of T-cell leukemia Jurkat clone E6-1 cells.
Meng J, Su R, Wang L, Yuan B, Li L
PeerJ 2021;9:e10692
PeerJ 2021;9:e10692
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Xie C, Shi Y, Chen Z, Zhou X, Luo P, Hong C, Tian N, Wu Y, Zhou Y, Lin Y, Dou H, Wu A, Huang Q, Zhang X, Wang X
Frontiers in cell and developmental biology 2021;9:787278
Frontiers in cell and developmental biology 2021;9:787278
TGR5 Activation Ameliorates Mitochondrial Homeostasis via Regulating the PKCδ/Drp1-HK2 Signaling in Diabetic Retinopathy.
Zhang MY, Zhu L, Zheng X, Xie TH, Wang W, Zou J, Li Y, Li HY, Cai J, Gu S, Yao Y, Wei TT
Frontiers in cell and developmental biology 2021;9:759421
Frontiers in cell and developmental biology 2021;9:759421
LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5.
Gui Z, Zhao Z, Sun Q, Shao G, Huang J, Zhao W, Kuang Y
Frontiers in cell and developmental biology 2021;9:749129
Frontiers in cell and developmental biology 2021;9:749129
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806
Frontiers in cell and developmental biology 2021;9:679806
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, Cai Y
Frontiers in cell and developmental biology 2021;9:676789
Frontiers in cell and developmental biology 2021;9:676789
Expression Level of ADAMTS1 in Granulosa Cells of PCOS Patients Is Related to Granulosa Cell Function, Oocyte Quality, and Embryo Development.
Yang G, Yao G, Xu Z, Fan H, Liu X, He J, Kong Y, Kong D, Bai Y, He Q, Zhang T, Zhang J, Sun Y
Frontiers in cell and developmental biology 2021;9:647522
Frontiers in cell and developmental biology 2021;9:647522
Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria.
Jia CM, Zhang FW, Wang SJ, Wang W, Li Y
Frontiers in cell and developmental biology 2021;9:622507
Frontiers in cell and developmental biology 2021;9:622507
Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.
Shang Y, Wang Q, Li J, Liu H, Zhao Q, Huang X, Dong H, Chen W, Gui R, Nie X
Frontiers in chemistry 2021;9:522708
Frontiers in chemistry 2021;9:522708
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Liao ZQ, Jiang YN, Su ZL, Bi HL, Li JT, Li CL, Yang XL, Zhang Y, Xie X
Frontiers in cardiovascular medicine 2021;8:809689
Frontiers in cardiovascular medicine 2021;8:809689
Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
Lin Z, Lin Z, Zhao Y, Cheng N, Zhang D, Lin J, Zhang H, Lin D
Frontiers in veterinary science 2021;8:772687
Frontiers in veterinary science 2021;8:772687
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis.
Li Q, Xu M, Li Z, Li T, Wang Y, Chen Q, Wang Y, Feng J, Yin X, Lu C
Frontiers in cardiovascular medicine 2021;8:768947
Frontiers in cardiovascular medicine 2021;8:768947
Citric Acid Promoting B Lymphocyte Differentiation and Anti-epithelial Cells Apoptosis Mediate the Protective Effects of Hermetia illucens Feed in ETEC Induced Piglets Diarrhea.
Liu M, Yuan B, Jin X, Zhu M, Xu H, Xie G, Wang Z, Zhang X, Xu Z, Li B, Huang Y, Lv Y, Wang W
Frontiers in veterinary science 2021;8:751861
Frontiers in veterinary science 2021;8:751861
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.
Hou X, Huang M, Zeng X, Zhang Y, Sun A, Wu Q, Zhu L, Zhao H, Liao Y
Frontiers in molecular biosciences 2021;8:698975
Frontiers in molecular biosciences 2021;8:698975
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336
Frontiers in cardiovascular medicine 2021;8:691336
Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Yang W, Feng Q, Li M, Su J, Wang P, Wang X, Yin Y, Wang X, Zhao M
Frontiers in molecular biosciences 2021;8:684262
Frontiers in molecular biosciences 2021;8:684262
Secreted Frizzled-Related Protein 5 Protects Against Cardiac Rupture and Improves Cardiac Function Through Inhibiting Mitochondrial Dysfunction.
Huang X, Yan Y, Zheng W, Ma Y, Wang X, Gong W, Nie S
Frontiers in cardiovascular medicine 2021;8:682409
Frontiers in cardiovascular medicine 2021;8:682409
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.
Gu L, Ren F, Fang X, Yuan L, Liu G, Wang S
Frontiers in medicine 2021;8:660614
Frontiers in medicine 2021;8:660614
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643
Frontiers in cardiovascular medicine 2021;8:659643
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Erythropoietin Attenuates Experimental Contrast-Induced Nephrology: A Role for the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway.
Yang J, Zhou J, Wang X, Ji L, Wang S, Chen X, Yang L
Frontiers in medicine 2021;8:634882
Frontiers in medicine 2021;8:634882
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Yao M, Zhang J, Li Z, Bai X, Ma J, Li Y
Frontiers in medicine 2021;8:630962
Frontiers in medicine 2021;8:630962
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway.
Sun H, Zhang T, Liu R, Cao W, Zhang Z, Liu Z, Qian W, Wang D, Yu D, Zhong C
Nutrition and cancer 2021;73(7):1157-1167
Nutrition and cancer 2021;73(7):1157-1167
EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells.
Ji Q, Liu J, Wang G, Liu L, Zhong J
Genetics and molecular biology 2021;44(3):e20200414
Genetics and molecular biology 2021;44(3):e20200414
Shen-fu injection alleviates acute renal injury by reducing cytokine levels and modulating apoptosis in a porcine hemorrhagic shock model.
Yuan W, Wu J, Zhang Q, Liang Y, Zhang M, Qin H, Li CS
Acta cirurgica brasileira 2021;36(4):e360405
Acta cirurgica brasileira 2021;36(4):e360405
Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Xu J, Zhan T, Zheng W, Huang YK, Chen K, Zhang XH, Ren P, Huang X
Acta cirurgica brasileira 2021;35(12):e351202
Acta cirurgica brasileira 2021;35(12):e351202
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p.
Wang L, Li S, Qi L, Ling L
Mediators of inflammation 2021;2021:9978882
Mediators of inflammation 2021;2021:9978882
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Yang F, He X, Chen T, Liu J, Luo Z, Sun S, Qin D, Huang W, Tang Y, Liu C, Luo F
Oxidative medicine and cellular longevity 2021;2021:9426314
Oxidative medicine and cellular longevity 2021;2021:9426314
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Wang Y, Wang J, Yang J, Kang J, Xue F, Chang S, Ji H, Zang H, Zhou X, Wang G, Fan W, Yan X, Guo J, Ren X, Tian J
Oxidative medicine and cellular longevity 2021;2021:8889408
Oxidative medicine and cellular longevity 2021;2021:8889408
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
Wang B, Ke W, Wang K, Li G, Ma L, Lu S, Xiang Q, Liao Z, Luo R, Song Y, Hua W, Wu X, Zhang Y, Zeng X, Yang C
Oxidative medicine and cellular longevity 2021;2021:8884922
Oxidative medicine and cellular longevity 2021;2021:8884922
l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.
Zeng L, Lin L, Chen L, Xiao W, Gong Z
Oxidative medicine and cellular longevity 2021;2021:8850112
Oxidative medicine and cellular longevity 2021;2021:8850112
Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer.
Hu C, Cao Y, Li P, Tang X, Yang M, Gu S, Xiong K, Li T, Xiao T
Journal of oncology 2021;2021:8281718
Journal of oncology 2021;2021:8281718
Schisandrin Protects against Norepinephrine-Induced Myocardial Hypertrophic Injury by Inhibiting the JAK2/STAT3 Signaling Pathway.
Yang M, Jiang XC, Wang L, Cui DA, Zhang JY, Wang XR, Feng HP, Zhang K, Zhang K, Li JX, Wang XZ
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8129512
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8129512
Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats.
Zhang Y, Weng Y, Wang D, Wang R, Wang L, Zhou J, Shen S, Wang H, Wang Y
Oxidative medicine and cellular longevity 2021;2021:7382900
Oxidative medicine and cellular longevity 2021;2021:7382900
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY
Journal of immunology research 2021;2021:6696606
Journal of immunology research 2021;2021:6696606
TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver Injury of CD38(-/-) Sepsis Mice.
Zhang H, Du Y, Guo Y, Wang Z, Li H, Lv Z, Zeng L, Chen Y, Xie Z, Li R
Journal of immunology research 2021;2021:6687555
Journal of immunology research 2021;2021:6687555
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J, Bu P
Oxidative medicine and cellular longevity 2021;2021:6668887
Oxidative medicine and cellular longevity 2021;2021:6668887
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Zhang J, Cheng P, Dai W, Ji J, Wu L, Feng J, Wu J, Yu Q, Li J, Guo C
PPAR research 2021;2021:6658944
PPAR research 2021;2021:6658944
Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation.
Zhu JJ, Yu BY, Huang XK, He MZ, Chen BW, Chen TT, Fang HY, Chen SQ, Fu XQ, Li PJ, Lin ZL, Zhu JH
Oxidative medicine and cellular longevity 2021;2021:6654954
Oxidative medicine and cellular longevity 2021;2021:6654954
Exploring the Therapeutic Mechanism of Tingli Dazao Xiefei Decoction on Heart Failure Based on Network Pharmacology and Experimental Study.
Zhao DD, Zhang XQ, Yang T, Liu Q, Lan ZZ, Yang XL, Qu HY, Zhou H
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6645878
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6645878
Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy during Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3β/PPARα Pathway.
Cheng Z, Guo C
PPAR research 2021;2021:6632137
PPAR research 2021;2021:6632137
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
Zhang S, Liang W, Abulizi Y, Xu T, Cao R, Xun C, Zhang J, Sheng W
BioMed research international 2021;2021:6631562
BioMed research international 2021;2021:6631562
PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway.
Wu L, Yu Q, Cheng P, Guo C
PPAR research 2021;2021:6626295
PPAR research 2021;2021:6626295
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Han Y, Ma R, Cao G, Liu H, He L, Tang L, Li H, Luo Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
You Z, He L, Yan N
Journal of healthcare engineering 2021;2021:6394514
Journal of healthcare engineering 2021;2021:6394514
Imbalance of Autophagy and Apoptosis Induced by Oxidative Stress May Be Involved in Thyroid Damage Caused by Sleep Deprivation in Rats.
Li Y, Zhang W, Liu M, Zhang Q, Lin Z, Jia M, Liu D, Lin L
Oxidative medicine and cellular longevity 2021;2021:5645090
Oxidative medicine and cellular longevity 2021;2021:5645090
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Zhao J, Lan W, Peng J, Guan B, Liu J, Zhang M, Zhan Z, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Li BL, Liu X, Gao M, Zhang F, Chen X, He Z, Wang J, Tian W, Chen D, Zhou Z, Liu S
Oxidative medicine and cellular longevity 2021;2021:5608133
Oxidative medicine and cellular longevity 2021;2021:5608133
Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway.
Wu D, Liu Z, Wang Y, Zhang Q, Li J, Zhong P, Xie Z, Ji A, Li Y
Oxidative medicine and cellular longevity 2021;2021:5599997
Oxidative medicine and cellular longevity 2021;2021:5599997
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Inhibition of α-Synuclein Accumulation Improves Neuronal Apoptosis and Delayed Postoperative Cognitive Recovery in Aged Mice.
Li Y, Yuan Y, Li Y, Han D, Liu T, Yang N, Mi X, Hong J, Liu K, Song Y, He J, Zhou Y, Han Y, Shi C, Yu S, Zou P, Guo X, Li Z
Oxidative medicine and cellular longevity 2021;2021:5572899
Oxidative medicine and cellular longevity 2021;2021:5572899
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Bai Y, Feng Y, Jiang B, Yang Y, Pei Z, Yang Q, Cui Y
BioMed research international 2021;2021:5512518
BioMed research international 2021;2021:5512518
Saikosaponin D Inhibits the Proliferation and Promotes the Apoptosis of Rat Hepatic Stellate Cells by Inducing Autophagosome Formation.
Jiang H, Liu J, Zhang K, Zeng Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5451758
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5451758
Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF.
Liu H, Yang H, Qin Z, Chen Y, Yu H, Li W, Zhu X, Cai J, Chen J, Zhang M
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4862164
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4862164
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Du Y, Zhong F, Cheng H, Li T, Chen Y, Tan P, Huang M, Liang T, Liu Y, Xia X, Fu W
Oxidative medicine and cellular longevity 2021;2021:4628050
Oxidative medicine and cellular longevity 2021;2021:4628050
Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10.
Yuan C, Bai R, Gao Y, Jiang X, Li S, Sun W, Li Y, Huang Z, Gong Y, Xie C
Oxidative medicine and cellular longevity 2021;2021:4522210
Oxidative medicine and cellular longevity 2021;2021:4522210
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Pei Z, Wang X, Yang C, Dong M, Wang F
Oxidative medicine and cellular longevity 2021;2021:3899356
Oxidative medicine and cellular longevity 2021;2021:3899356
Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.
Xin Y, Shang X, Sun X, Liu Y, Xu G, Xue G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
Zhu P, Yang Q, Li G, Chang Q
Disease markers 2021;2021:1602797
Disease markers 2021;2021:1602797
miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.
Li D, Zhang Y, Li Y, Wang X, Wang F, Du J, Zhang H, Shi H, Wang Y, Gao Y, Feng Y, Yan J, Xue Y, Yang Y, Zhang J
BioMed research international 2021;2021:1503403
BioMed research international 2021;2021:1503403
USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin.
Qin T, Cui XY, Xiu H, Huang C, Sun ZN, Xu XM, Li LH, Yue L
International journal of medical sciences 2021;18(2):325-334
International journal of medical sciences 2021;18(2):325-334
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
Chen G, Liu B, Chen S, Li H, Liu J, Mai Z, Chen E, Zhou C, Sun G, Guo Z, Lei L, Huang S, Zhang L, Li M, Tan N, Li H, Liao Y, Liu J, Chen J, Liu Y
International journal of biological sciences 2021;17(3):882-896
International journal of biological sciences 2021;17(3):882-896
Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1α/IP(3)R signaling pathway.
Liu Y, Hu R, Shen H, Mo Q, Wang X, Zhang G, Li S, Liang G, Hou N, Luo J
International journal of biological sciences 2021;17(13):3672-3688
International journal of biological sciences 2021;17(13):3672-3688
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Liu Y, Lv H, Li X, Liu J, Chen S, Chen Y, Jin Y, An R, Yu S, Wang Z
International journal of biological sciences 2021;17(13):3522-3537
International journal of biological sciences 2021;17(13):3522-3537
Vagal Nerve Stimulation Protects Against Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis.
Zhang LN, Zhang XW, Li CQ, Guo J, Chen YP, Chen SL
Neuropsychiatric disease and treatment 2021;17:905-913
Neuropsychiatric disease and treatment 2021;17:905-913
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress.
Liu Z, Fei B, Xie L, Liu J, Chen X, Zhu W, Lv L, Ma W, Gao Z, Hou J, She W
Open life sciences 2021;16(1):695-702
Open life sciences 2021;16(1):695-702
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK
International journal of nanomedicine 2021;16:269-281
International journal of nanomedicine 2021;16:269-281
Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson's Disease Pathology.
Yuan X, Yang Y, Xia D, Meng L, He M, Liu C, Zhang Z
Frontiers in neuroscience 2021;15:807988
Frontiers in neuroscience 2021;15:807988
Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats.
Cheng WJ, Li P, Huang WY, Huang Y, Chen WJ, Chen YP, Shen JL, Chen JK, Long NS, Meng XJ
Frontiers in behavioral neuroscience 2021;15:783056
Frontiers in behavioral neuroscience 2021;15:783056
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Wang C, Chen H, Jiang HH, Mao BB, Yu H
Frontiers in neuroscience 2021;15:772401
Frontiers in neuroscience 2021;15:772401
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments.
Tu Q, Zhu Y, Yuan Y, Guo L, Liu L, Yao L, Zou Y, Li J, Chen F
Drug design, development and therapy 2021;15:289-303
Drug design, development and therapy 2021;15:289-303
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
Ding L, Ren C, Yang L, Wu Z, Li F, Jiang D, Zhu Y, Lu J
Drug design, development and therapy 2021;15:1797-1810
Drug design, development and therapy 2021;15:1797-1810
Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells.
Shi ML, Chen YF, Liao HF
International journal of ophthalmology 2021;14(2):186-193
International journal of ophthalmology 2021;14(2):186-193
Gαi1 Promoted Proliferation, Migration and Invasion via Activating the Akt-mTOR/Erk-MAPK Signaling Pathway in Renal Cell Carcinoma.
Chen Z, Zhang Y, Wu X, Zhang J, Xu W, Shen C, Zheng B
OncoTargets and therapy 2021;14:2941-2952
OncoTargets and therapy 2021;14:2941-2952
Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma.
Gu W, Chen P, Ren P, Wang Y, Li X, Gong M
OncoTargets and therapy 2021;14:2917-2927
OncoTargets and therapy 2021;14:2917-2927
Salusin-β Mediates High Glucose-Induced Inflammation and Apoptosis in Retinal Capillary Endothelial Cells via a ROS-Dependent Pathway in Diabetic Retinopathy.
Wang H, Zhang M, Zhou H, Cao L, Zhou J, Chen Q, Zhang X
Diabetes, metabolic syndrome and obesity : targets and therapy 2021;14:2291-2308
Diabetes, metabolic syndrome and obesity : targets and therapy 2021;14:2291-2308
Microarray analysis reveals a potential role of lncRNA expression in remote ischemic preconditioning in myocardial ischemia-reperfusion injury.
Lou Z, Wu W, Chen R, Xia J, Shi H, Ge H, Xue J, Wang H, Lin Z, Chu M, Zhao Q
American journal of translational research 2021;13(1):234-252
American journal of translational research 2021;13(1):234-252
lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis.
Dang Y, Zhou Y, Ou X, Wang Q, Wei D, Xie F
Cancer management and research 2021;13:7277-7288
Cancer management and research 2021;13:7277-7288
MALAT-1 is Associated with the Doxorubicin Resistance in U-2OS Osteosarcoma Cells.
Liu C, Han X, Li B, Huang S, Zhou Z, Wang Z, Wang W
Cancer management and research 2021;13:6879-6889
Cancer management and research 2021;13:6879-6889
SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling.
Zhang H, Xu Y, Deng G, Yuan F, Tan Y, Gao L, Sun Q, Qi Y, Yang K, Geng R, Jiang H, Liu B, Chen Q
Journal of Cancer 2021;12(9):2756-2767
Journal of Cancer 2021;12(9):2756-2767
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation.
Xin J, Cheng W, Yu Y, Chen J, Zhang X, Shao S
Frontiers in pharmacology 2021;12:806829
Frontiers in pharmacology 2021;12:806829
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Fan S, Wang C, Huang K, Liang M
Frontiers in physiology 2021;12:790345
Frontiers in physiology 2021;12:790345
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Wang D, Song M, Shen LF, Han L, Zhu P, Jia X, Shang GK, Cao Y, Zhang W, Zhong M, Wang ZH
Frontiers in physiology 2021;12:786895
Frontiers in physiology 2021;12:786895
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.
Yang J, Wu Z, Yang L, Jeong JH, Zhu Y, Lu J, Wang B, Wang N, Wang Y, Shen K, Li R
Frontiers in pharmacology 2021;12:785981
Frontiers in pharmacology 2021;12:785981
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway.
Li J, Zhang Z, Wang L, Jiang L, Qin Z, Zhao Y, Su B
Frontiers in pharmacology 2021;12:782660
Frontiers in pharmacology 2021;12:782660
JieZe-1 Alleviates HSV-2 Infection-Induced Genital Herpes in Balb/c Mice by Inhibiting Cell Apoptosis via Inducing Autophagy.
Shao Q, Wu F, Liu T, Wang W, Liu T, Jin X, Xu L, Ma Y, Huang G, Chen Z
Frontiers in pharmacology 2021;12:775521
Frontiers in pharmacology 2021;12:775521
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Li G, Zhong Y, Wang W, Jia X, Zhu H, Jiang W, Song Y, Xu W, Wu S
Frontiers in pharmacology 2021;12:770667
Frontiers in pharmacology 2021;12:770667
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Chu BX, Li YN, Liu N, Yuan LX, Chen SY, Zhu YH, Wang JF
Frontiers in immunology 2021;12:757909
Frontiers in immunology 2021;12:757909
Ultrasound-Induced Destruction of Nitric Oxide-Loaded Microbubbles in the Treatment of Thrombus and Ischemia-Reperfusion Injury.
Liang Z, Chen H, Gong X, Shi B, Lin L, Tao F, Wu Q, Fang M, Li H, Lu C, Xu H, Zhao Y, Chen B
Frontiers in pharmacology 2021;12:745693
Frontiers in pharmacology 2021;12:745693
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology.
Yong C, Zhang Z, Huang G, Yang Y, Zhu Y, Qian L, Tian F, Liu L, Wu Q, Xu Z, Chen C, Zhao J, Gao K, Zhou E
Frontiers in pharmacology 2021;12:717744
Frontiers in pharmacology 2021;12:717744
Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach.
Yang R, Yang H, Wei J, Li W, Yue F, Song Y, He X, Hu K
Frontiers in pharmacology 2021;12:717652
Frontiers in pharmacology 2021;12:717652
The Abscopal Effects of Cranial Irradiation Induce Testicular Damage in Mice.
Guo L, Qin TZ, Liu LY, Lai PP, Xue YZ, Jing YT, Zhang W, Li W, Li J, Ding GR
Frontiers in physiology 2021;12:717571
Frontiers in physiology 2021;12:717571
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Zhou S, Wu H, Ning W, Wu X, Xu X, Ma Y, Li X, Hu J, Wang C, Wang J
Frontiers in pharmacology 2021;12:717529
Frontiers in pharmacology 2021;12:717529
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Frontiers in immunology 2021;12:715098
Frontiers in immunology 2021;12:715098
PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas.
Zhu K, Cheng X, Wang S, Zhang H, Zhang Y, Wang X, Chen Y, Wu J
Frontiers in endocrinology 2021;12:706909
Frontiers in endocrinology 2021;12:706909
Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation.
Ma S, Xu H, Huang W, Gao Y, Zhou H, Li X, Zhang W
Frontiers in physiology 2021;12:706359
Frontiers in physiology 2021;12:706359
Clemastine Fumarate Attenuates Myocardial Ischemia Reperfusion Injury Through Inhibition of Mast Cell Degranulation.
Meng S, Sun X, Juan Z, Wang M, Wang R, Sun L, Li Y, Xin A, Li S, Li Y
Frontiers in pharmacology 2021;12:704852
Frontiers in pharmacology 2021;12:704852
miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.
Sun X, Ji G, Li P, Li W, Li J, Zhu L
Frontiers in endocrinology 2021;12:695164
Frontiers in endocrinology 2021;12:695164
Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study.
Yan J, Zhang Y, Sheng G, Ni B, Xiao Y, Wang S, Wang T, Ma Y, Wang H, Wu H, Tu C
Frontiers in pharmacology 2021;12:687033
Frontiers in pharmacology 2021;12:687033
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Zhang P, Yang Q
Frontiers in genetics 2021;12:682856
Frontiers in genetics 2021;12:682856
Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.
Xu ZQ, Zhang JJ, Kong N, Zhang GY, Ke P, Han T, Su DF, Liu C
Frontiers in pharmacology 2021;12:676589
Frontiers in pharmacology 2021;12:676589
Case Report: 7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth.
Wang A, Li L, Li M, Wang S, Wang C
Frontiers in pharmacology 2021;12:664176
Frontiers in pharmacology 2021;12:664176
Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF-κB Signaling Pathway.
Xu LN, Wang SH, Su XL, Komal S, Fan HK, Xia L, Zhang LR, Han SN
Frontiers in pharmacology 2021;12:662726
Frontiers in pharmacology 2021;12:662726
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells.
Wang Y, Shen H, Sun Q, Zhao L, Liu H, Ye L, Xu Y, Cai J, Li Y, Gao L, Tan Y, Liu B, Chen Q
Frontiers in pharmacology 2021;12:659511
Frontiers in pharmacology 2021;12:659511
SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease.
Li X, Liu T, Wu TT, Feng Y, Peng SJ, Yin H, Wu YC
Frontiers in neurology 2021;12:652882
Frontiers in neurology 2021;12:652882
Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.
Ji W, Wan T, Zhang F, Zhu X, Guo S, Mei X
Frontiers in pharmacology 2021;12:641058
Frontiers in pharmacology 2021;12:641058
Knockdown of RIPK2 Inhibits Proliferation and Migration, and Induces Apoptosis via the NF-κB Signaling Pathway in Gastric Cancer.
Yang Q, Tian S, Liu Z, Dong W
Frontiers in genetics 2021;12:627464
Frontiers in genetics 2021;12:627464
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression.
Zhang L, Zhang Y, Zhu M, Pei L, Deng F, Chen J, Zhang S, Cong Z, Du W, Xiao X
Frontiers in pharmacology 2021;12:590602
Frontiers in pharmacology 2021;12:590602
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Lu J, Liu SY, Zhang J, Yang GM, Gao GB, Yu NN, Li YP, Li YX, Ma ZQ, Wang Y, Lu CH
American journal of cancer research 2021;11(7):3575-3593
American journal of cancer research 2021;11(7):3575-3593
BLM interaction with EZH2 regulates MDM2 expression and is a poor prognostic biomarker for prostate cancer.
Ruan Y, Xu H, Ji X, Zhao J
American journal of cancer research 2021;11(4):1347-1368
American journal of cancer research 2021;11(4):1347-1368
(125)I seed implantation brachytherapy for glottic carcinoma: an experimental and clinical study.
Jiao D, Zhou X, Yao Y, Chen J, Lei Q, Ren J, Han X
American journal of cancer research 2021;11(4):1321-1334
American journal of cancer research 2021;11(4):1321-1334
Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway.
Xiong W, Xiong Z, Song A, Lei C, Ye C, Zhang C
Theranostics 2021;11(10):4637-4654
Theranostics 2021;11(10):4637-4654
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Liu WJ, Pan PY, Sun Y, Wang JB, Zhou H, Xie X, Duan ZY, Dong HY, Chen WN, Zhang LD, Wang C
Frontiers in oncology 2021;11:794735
Frontiers in oncology 2021;11:794735
Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
Cheng Y, Wang G, Zhao L, Dai S, Han J, Hu X, Zhou C, Wang F, Ma H, Li B, Meng Z
Frontiers in oncology 2021;11:753598
Frontiers in oncology 2021;11:753598
Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.
Wang S, Chang X, Zhang J, Li J, Wang N, Yang B, Pan B, Zheng Y, Wang X, Ou H, Wang Z
Frontiers in oncology 2021;11:745584
Frontiers in oncology 2021;11:745584
High-Risk HPV16 E6 Activates the cGMP/PKG Pathway Through Glycosyltransferase ST6GAL1 in Cervical Cancer Cells.
Wang J, Liu G, Liu M, Cai Q, Yao C, Chen H, Song N, Yuan C, Tan D, Hu Y, Xiang Y, Xiang T
Frontiers in oncology 2021;11:716246
Frontiers in oncology 2021;11:716246
Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
Di Y, Jiang Y, Shen X, Liu J, Gao Y, Cai H, Sun X, Ning D, Liu B, Lei J, Jin S
Frontiers in oncology 2021;11:679348
Frontiers in oncology 2021;11:679348
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184
Frontiers in oncology 2021;11:661184
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway.
Sun Y, Liu W, Zhao Q, Zhang R, Wang J, Pan P, Shang H, Liu C, Wang C
Frontiers in oncology 2021;11:653596
Frontiers in oncology 2021;11:653596
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
Tan L, Tang Y, Li H, Li P, Ye Y, Cen J, Gui C, Luo J, Cao J, Wei J
Frontiers in oncology 2021;11:641833
Frontiers in oncology 2021;11:641833
MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
Qian XL, Zhou F, Xu S, Jiang J, Chen ZP, Wang SK, Zuo Y, Ni C
Frontiers in oncology 2021;11:638537
Frontiers in oncology 2021;11:638537
Downregulating Long Non-coding RNAs CTBP1-AS2 Inhibits Colorectal Cancer Development by Modulating the miR-93-5p/TGF-β/SMAD2/3 Pathway.
Li Q, Yue W, Li M, Jiang Z, Hou Z, Liu W, Ma N, Gan W, Li Y, Zhou T, Yue W, Chen S
Frontiers in oncology 2021;11:626620
Frontiers in oncology 2021;11:626620
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Zhang L, Xie Z, Yu H, Du H, Wang X, Cai J, Qiu Y, Chen R, Jiang X, Liu Z, Li Y, Chen T
Annals of translational medicine 2021 Sep;9(18):1429
Annals of translational medicine 2021 Sep;9(18):1429
Homoharringtonine inhibits the progression of hepatocellular carcinoma by suppressing the PI3K/AKT/GSK3β/Slug signaling pathway.
Liu HY, Dong TX, Li ZZ, Li TT, Jiang J, Zhu MW, An TT, Chen YD, Yang XH
Neoplasma 2021 Sep;68(5):924-937
Neoplasma 2021 Sep;68(5):924-937
Gastrodin protects against high glucose-induced cardiomyocyte toxicity via GSK-3β-mediated nuclear translocation of Nrf2.
Dong Z, Bian L, Wang YL, Sun LM
Human & experimental toxicology 2021 Sep;40(9):1584-1597
Human & experimental toxicology 2021 Sep;40(9):1584-1597
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Wang D, Liu J, Jiang H
Environmental toxicology 2021 Sep;36(9):1953-1964
Environmental toxicology 2021 Sep;36(9):1953-1964
Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell.
Zhang B, Li X, Zhang X, Ye J, Zhao W, Zhang M, Xing J, Qi W, Ye L
Environmental toxicology 2021 Sep;36(9):1944-1952
Environmental toxicology 2021 Sep;36(9):1944-1952
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Wang H, Yang H, Shi Y, Xiao Y, Yin Y, Jiang B, Ren H, Chen W, Xue Q, Xu X
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.
Jiang W, Wan L, Chen P, Lu W
Saudi journal of biological sciences 2021 Sep;28(9):4987-4993
Saudi journal of biological sciences 2021 Sep;28(9):4987-4993
Polystyrene microplastics induce blood-testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats.
Li S, Wang Q, Yu H, Yang L, Sun Y, Xu N, Wang N, Lei Z, Hou J, Jin Y, Zhang H, Li L, Xu F, Zhang L
Environmental science and pollution research international 2021 Sep;28(35):47921-47931
Environmental science and pollution research international 2021 Sep;28(35):47921-47931
miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.
Yu Q, Chen S, Tang H, Yang H, Zhang J, Shi X, Li J, Guo W, Zhang S
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
Wu J, Wu T, Zheng S, Huang Y, Wang L
Experimental eye research 2021 Sep;210:108696
Experimental eye research 2021 Sep;210:108696
Knockdown of PYCR1 suppressed the malignant phenotype of human hepatocellular carcinoma cells via inhibiting the AKT pathway activation.
Guo J, Cheng X, Tian Y, Li B, Zhang X, Gao X, An Y
Reproductive biology 2021 Sep;21(3):100534
Reproductive biology 2021 Sep;21(3):100534
Expression and purification of a recombinant ELRL-MAP30 with dual-targeting anti-tumor bioactivity.
Chen WW, Zhang HR, Huang ZG, Zhou ZY, Lou QW, Jiang XY, Zhu ZH
Protein expression and purification 2021 Sep;185:105893
Protein expression and purification 2021 Sep;185:105893
Upregulation of thioredoxin contributes to inhibiting diabetic hearing impairment.
Ren X, Lv J, Fu Y, Zhang N, Zhang C, Dong Z, Chudhary M, Zhong S, Kong L, Kong H
Diabetes research and clinical practice 2021 Sep;179:109025
Diabetes research and clinical practice 2021 Sep;179:109025
Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Li H, Yang W, Zhang M, He T, Zhou F, G Herman J, Hu L, Guo M
Epigenomics 2021 Sep;13(17):1403-1419
Epigenomics 2021 Sep;13(17):1403-1419
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway.
Xian M, Cai J, Zheng K, Liu Q, Liu Y, Lin H, Liang S, Wang S
Food & function 2021 Sep 7;12(17):8056-8067
Food & function 2021 Sep 7;12(17):8056-8067
Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells.
Xu HZ, Li TF, Wang C, Ma Y, Liu Y, Zheng MY, Liu ZJ, Chen JB, Li K, Sun SK, Komatsu N, Xu YH, Zhao L, Chen X
Journal of nanobiotechnology 2021 Sep 6;19(1):268
Journal of nanobiotechnology 2021 Sep 6;19(1):268
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Li TF, Xu HZ, Xu YH, Yu TT, Tang JM, Li K, Wang C, Peng XC, Li QR, Sang XY, Zheng MY, Liu Y, Zhao L, Chen X
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
Zeng S, Chen L, Sun Q, Zhao H, Yang H, Ren S, Liu M, Meng X, Xu H
European journal of pharmacology 2021 Sep 5;906:174253
European journal of pharmacology 2021 Sep 5;906:174253
Dual-enzymatically cross-linked gelatin hydrogel promotes neural differentiation and neurotrophin secretion of bone marrow-derived mesenchymal stem cells for treatment of moderate traumatic brain injury.
Li J, Zhang D, Guo S, Zhao C, Wang L, Ma S, Guan F, Yao M
International journal of biological macromolecules 2021 Sep 30;187:200-213
International journal of biological macromolecules 2021 Sep 30;187:200-213
WAC, a novel GBM tumor suppressor, induces GBM cell apoptosis and promotes autophagy.
Wang Y, Zhang S, Sun Q, Yuan F, Zhao L, Ye Z, Li Y, Wang R, Jiang H, Hu P, Tian D, Liu B
Medical oncology (Northwood, London, England) 2021 Sep 28;38(11):132
Medical oncology (Northwood, London, England) 2021 Sep 28;38(11):132
Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis.
Yue TT, Zhang N, Li JH, Lu XY, Wang XC, Li X, Zhang HB, Cheng SQ, Wang BB, Gong PT, Zhang XC
Parasites & vectors 2021 Sep 26;14(1):498
Parasites & vectors 2021 Sep 26;14(1):498
Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway.
Lu H, Jia C, Wu D, Jin H, Lin Z, Pan J, Li X, Wang W
Cell death & disease 2021 Sep 23;12(10):865
Cell death & disease 2021 Sep 23;12(10):865
Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration.
Jin J, Li M, Li J, Li B, Duan L, Yang F, Gu N
ACS applied materials & interfaces 2021 Sep 22;13(37):43880-43891
ACS applied materials & interfaces 2021 Sep 22;13(37):43880-43891
Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer.
Zhu X, Yu Z, Feng L, Deng L, Fang Z, Liu Z, Li Y, Wu X, Qin L, Guo R, Zheng Y
Carbohydrate polymers 2021 Sep 15;268:118237
Carbohydrate polymers 2021 Sep 15;268:118237
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.
Li N, Yang F, Liu DY, Guo JT, Ge N, Sun SY
World journal of gastrointestinal oncology 2021 Sep 15;13(9):1164-1183
World journal of gastrointestinal oncology 2021 Sep 15;13(9):1164-1183
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Tetramethylpyrazine inhibits neutrophil extracellular traps formation and alleviates hepatic ischemia/reperfusion injury in rat liver transplantation.
Liu Y, Qin X, Lei Z, Chai H, Huang Z, Wu Z
Experimental cell research 2021 Sep 1;406(1):112719
Experimental cell research 2021 Sep 1;406(1):112719
IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.
Che Y, Tian Y, Chen R, Xia L, Liu F, Su Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Sep 1;1867(9):166171
Biochimica et biophysica acta. Molecular basis of disease 2021 Sep 1;1867(9):166171
miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.
Han S, Lin F, Ruan Y, Zhao S, Yuan R, Ning J, Jiang K, Xie J, Li H, Li C, Rao T, Yu W, Xia Y, Zhou X, Cheng F
International immunopharmacology 2021 Oct;99:108022
International immunopharmacology 2021 Oct;99:108022
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Chen L, Yin Y, Liu G
Annals of translational medicine 2021 Oct;9(20):1547
Annals of translational medicine 2021 Oct;9(20):1547
Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3β/β-catenin pathway.
Li C, Yang P, Liu B, Bu J, Liu H, Guo J, Hasegawa T, Si H, Li M
Journal of molecular histology 2021 Oct;52(5):1081-1095
Journal of molecular histology 2021 Oct;52(5):1081-1095
Systematic screening identifies a TEAD4-S100A13 axis modulating cisplatin sensitivity of oral squamous cell carcinoma cells.
Li R, Li W, He F, Zhang M, Luo H, Tang H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2021 Oct;50(9):882-890
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2021 Oct;50(9):882-890
Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration.
Jing X, Wang Q, Du T, Zhang W, Liu X, Liu Q, Li T, Wang G, Chen F, Cui X
International journal of molecular medicine 2021 Oct;48(4)
International journal of molecular medicine 2021 Oct;48(4)
Arctigenin inhibits cholangiocarcinoma progression by regulating cell migration and cell viability via the N-cadherin and apoptosis pathway.
Janthamala S, Jusakul A, Kongpetch S, Kimawaha P, Klanrit P, Loilome W, Namwat N, Techasen A
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2049-2059
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2049-2059
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Nie Z, Zhang L, Chen W, Zhang Y, Wang W, Hua R, Zhang T, Zhao C, Gong M, Wu H
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
The regulation of Ero1-alpha in homocysteine-induced macrophage apoptosis and vulnerable plaque formation in atherosclerosis.
Zhang N, Zhu L, Wu X, Yan R, Yang S, Jiang X, Liu X, Liu X, Yan N, Cong G, Yang Z, Jia S
Atherosclerosis 2021 Oct;334:39-47
Atherosclerosis 2021 Oct;334:39-47
Exosomes derived from idiopathic gingival fibroma fibroblasts regulate gingival fibroblast proliferation and apoptosis.
Yin S, Jia F, Ran L, Xie L, Wu Z, Zhan Y, Zhang Y, Zhang M
Oral diseases 2021 Oct;27(7):1789-1795
Oral diseases 2021 Oct;27(7):1789-1795
Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells.
Yang S, Huang Y, Zhang H, Wang F, Shao L, Wang X
Oncology letters 2021 Oct;22(4):707
Oncology letters 2021 Oct;22(4):707
Hsa_circ_0004058 inhibits apoptosis of SRA01/04 cells by promoting autophagy via miR-186/ATG7 axis.
Wang Y, Wu Z, Huang Y, Zhang Y
Experimental eye research 2021 Oct;211:108721
Experimental eye research 2021 Oct;211:108721
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Li M, Chen X, Wang X, Wei X, Wang D, Liu X, Xu L, Batu W, Li Y, Guo B, Zhang L
Biochemical pharmacology 2021 Oct;192:114741
Biochemical pharmacology 2021 Oct;192:114741
LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury.
Tan X, Guo W, Peng Z, Gu C, Xiang P, Tu Y, Fei H, Liu X, Lu Y, Li M, Wang H, Luo Y, Yang J
Biochemical pharmacology 2021 Oct;192:114694
Biochemical pharmacology 2021 Oct;192:114694
Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway.
Sun CP, Zhang XY, Zhou JJ, Huo XK, Yu ZL, Morisseau C, Hammock BD, Ma XC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Oct;156:112516
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Oct;156:112516
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Li Q, Zhang Y, Yang Y, Huang S, Zou X, Wei C, Liang T, Zhong X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Ni Y, Yang Z, Agbana YL, Bai H, Wang L, Yang L, Yi Z, Cheng J, Zhang Q, Kuang Y, Zhu Y
Cancer science 2021 Oct;112(10):4075-4086
Cancer science 2021 Oct;112(10):4075-4086
Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis.
Liu JM, Li M, Luo W, Sun HB
Laboratory investigation; a journal of technical methods and pathology 2021 Oct;101(10):1308-1317
Laboratory investigation; a journal of technical methods and pathology 2021 Oct;101(10):1308-1317
8-Formylophiopogonanone B induces ROS-mediated apoptosis in nasopharyngeal carcinoma CNE-1 cells.
Zhang YJ, Mu ZL, Deng P, Liang YD, Wu LC, Yang LL, Zhou Z, Yu ZP
Toxicology research 2021 Oct;10(5):1052-1063
Toxicology research 2021 Oct;10(5):1052-1063
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
Zhao Y, Yang X, Li S, Zhang B, Li S, Wang X, Wang Y, Jia C, Chang Y, Wei W
Stem cell research & therapy 2021 Oct 9;12(1):535
Stem cell research & therapy 2021 Oct 9;12(1):535
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
Li SY, Shang J, Mao XM, Fan R, Li HQ, Li RH, Shen DY
European journal of pharmacology 2021 Oct 5;908:174370
European journal of pharmacology 2021 Oct 5;908:174370
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner.
Chen G, Zeng H, Li X, Liu J, Li Z, Xu R, Ma Y, Liu C, Xue B
Cell death & disease 2021 Oct 30;12(11):1034
Cell death & disease 2021 Oct 30;12(11):1034
Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase.
Raghubir M, Azeem SM, Hasnat R, Rahman CN, Wong L, Yan S, Huang YQ, Zhagui R, Blyufer A, Tariq I, Tam C, Lhamo S, Cecilio L, Chowdhury Y, ChandThakuri S, Mahajan SS
Scientific reports 2021 Oct 25;11(1):20974
Scientific reports 2021 Oct 25;11(1):20974
JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12.
Liang Y, Qian C, Xie Y, Huang X, Chen J, Ren Y, Fu Z, Li Y, Zeng T, Yang F, Zhou J, Li W, Yin Y, Wang C
Cell death discovery 2021 Oct 22;7(1):306
Cell death discovery 2021 Oct 22;7(1):306
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Sun XC, Wang Y, Zeng HF, Xi YM, Lin H, Han ZY, Chen KL
Cell death discovery 2021 Oct 21;7(1):304
Cell death discovery 2021 Oct 21;7(1):304
Design and Synthesis of Novel Betulin Derivatives Containing Thio-/Semicarbazone Moieties as Apoptotic Inducers through Mitochindria-Related Pathways.
Wang J, Wu J, Han Y, Zhang J, Lin Y, Wang H, Wang J, Liu J, Bu M
Molecules (Basel, Switzerland) 2021 Oct 21;26(21)
Molecules (Basel, Switzerland) 2021 Oct 21;26(21)
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation.
Feng T, Wang J, Cheng K, Lu Q, Zhao R, Wang S, Zhang Q, Ge L, Pan J, Song G, Wang L
Cancer biology & medicine 2021 Oct 18;19(7):1008-28
Cancer biology & medicine 2021 Oct 18;19(7):1008-28
Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.
Lu Y, Zhang M, Wei Q, Chen Z, Xing G, Yao J, Cao X
Biochemical and biophysical research communications 2021 Oct 15;574:1-7
Biochemical and biophysical research communications 2021 Oct 15;574:1-7
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Yao H, Yan J, Shao P, Wang Y, Liu T, Jiang J, Liu T
Toxicology letters 2021 Oct 15;351:145-154
Toxicology letters 2021 Oct 15;351:145-154
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M
European journal of medicinal chemistry 2021 Oct 15;222:113573
European journal of medicinal chemistry 2021 Oct 15;222:113573
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Yang H, Wan Z, Jin Y, Wang F, Zhang Y
Theriogenology 2021 Oct 15;174:139-148
Theriogenology 2021 Oct 15;174:139-148
EF24 exerts cytotoxicity against NSCLC via inducing ROS accumulation.
Chang M, Shang M, Yuan F, Guo W, Wang C
Cancer cell international 2021 Oct 12;21(1):531
Cancer cell international 2021 Oct 12;21(1):531
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Tan X, Cai D, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W, Wang H
Toxicology letters 2021 Oct 10;350:98-110
Toxicology letters 2021 Oct 10;350:98-110
Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.
Zhou X, Guo Q, Guo M, Li B, Peng W, Wang D, Ming D, Zheng B
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:742-753
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:742-753
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Wang D, Wei X, Chen X, Wang Q, Zhang J, Kalvakolanu DV, Guo B, Zhang L
Experimental cell research 2021 Oct 1;407(1):112799
Experimental cell research 2021 Oct 1;407(1):112799
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
Xu J, Wang Y, Wang Y, Wang Z, He X
Chemico-biological interactions 2021 Oct 1;348:109648
Chemico-biological interactions 2021 Oct 1;348:109648
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Zhou K, Wei Y, Li X, Yang X
Life sciences 2021 Oct 1;282:119798
Life sciences 2021 Oct 1;282:119798
Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
Tang J, Yao C, Liu Y, Yuan J, Wu L, Hosoi K, Yu S, Huang C, Wei H, Chen G
Ecotoxicology and environmental safety 2021 Oct 1;222:112531
Ecotoxicology and environmental safety 2021 Oct 1;222:112531
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
HMGB1 could restrict 1,3-β-glucan induced mice lung inflammation by affecting Beclin1 and Bcl2 interaction and promoting the autophagy of epithelial cells.
Zeng X, Liu F, Liu K, Xin J, Chen J
Ecotoxicology and environmental safety 2021 Oct 1;222:112460
Ecotoxicology and environmental safety 2021 Oct 1;222:112460
Effect of Perinatal Vitamin D Deficiency on Lung Mesenchymal Stem Cell Differentiation and Injury Repair Potential.
Sakurai R, Singh H, Wang Y, Harb A, Gornes C, Liu J, Rehan VK
American journal of respiratory cell and molecular biology 2021 Nov;65(5):521-531
American journal of respiratory cell and molecular biology 2021 Nov;65(5):521-531
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Oxidative stress-mediated apoptosis is involved in bisphenol S-induced reproductive toxicity in male C57BL/6 mice.
Dai W, He QZ, Zhu BQ, Zeng HC
Journal of applied toxicology : JAT 2021 Nov;41(11):1839-1851
Journal of applied toxicology : JAT 2021 Nov;41(11):1839-1851
N-acetylcysteine ameliorate cytotoxic injury in piglets sertoli cells induced by zearalenone and deoxynivalenol.
Cao L, Zhao J, Xu J, Zhu L, Rahman SU, Feng S, Li Y, Wu J, Wang X
Environmental science and pollution research international 2021 Nov;28(42):60276-60289
Environmental science and pollution research international 2021 Nov;28(42):60276-60289
Moderate mechanical stress suppresses the IL-1β-induced chondrocyte apoptosis by regulating mitochondrial dynamics.
Zhang J, Hao X, Chi R, Qi J, Xu T
Journal of cellular physiology 2021 Nov;236(11):7504-7515
Journal of cellular physiology 2021 Nov;236(11):7504-7515
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Wang L, Bao S, Liu X, Wang F, Zhang J, Dang P, Wang F, Li B, Lin Y
Ecotoxicology and environmental safety 2021 Nov;224:112703
Ecotoxicology and environmental safety 2021 Nov;224:112703
Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice.
Zhou L, Zhang C, Qiang Y, Huang M, Ren X, Li Y, Shao J, Xu L
Ecotoxicology and environmental safety 2021 Nov;224:112683
Ecotoxicology and environmental safety 2021 Nov;224:112683
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
Chen X, Xu P, Zhang H, Su X, Guo L, Zhou X, Wang J, Huang P, Zhang Q, Sun R
Oncology letters 2021 Nov;22(5):754
Oncology letters 2021 Nov;22(5):754
Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide.
Wang N, Zhu P, Huang R, Sun L, Dong D, Gao Y
Experimental and therapeutic medicine 2021 Nov;22(5):1246
Experimental and therapeutic medicine 2021 Nov;22(5):1246
miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E(2) Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride.
Chen Q, Li Z, Xu Z, Chen C, Wang J, Zhu J, Dong Z
Biological trace element research 2021 Nov;199(11):4119-4128
Biological trace element research 2021 Nov;199(11):4119-4128
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.
Chen YD, Cai FY, Mao YZ, Yang YS, Xu K, Liu XF, Fan WW, Chen W, Jiang FQ, Zhang H
Chinese journal of natural medicines 2021 Nov;19(11):815-824
Chinese journal of natural medicines 2021 Nov;19(11):815-824
INHBA transfection regulates proliferation, apoptosis and hormone synthesis in sheep granulosa cells.
Bao Y, Yao X, Li X, Ei-Samahy MA, Yang H, Liang Y, Liu Z, Wang F
Theriogenology 2021 Nov;175:111-122
Theriogenology 2021 Nov;175:111-122
Apatinib combined with Keytruda treatment induces apoptosis of gastric carcinoma cells through CES4/miR-616-5p/DUSP2 axis.
Zhang F, Yin Y, Xu W, Zhou Z, Sun X, Li P
Basic & clinical pharmacology & toxicology 2021 Nov;129(5):345-356
Basic & clinical pharmacology & toxicology 2021 Nov;129(5):345-356
Macrophages mediated delivery of chlorin e6 and treatment of lung cancer by photodynamic reprogramming.
Yu TT, Sang XY, Han N, Peng XC, Li QR, Xu X, Xiao RC, Xu HZ, Chen X, Wang MF, Li TF
International immunopharmacology 2021 Nov;100:108164
International immunopharmacology 2021 Nov;100:108164
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
African Swine Fever Virus pE199L Induces Mitochondrial-Dependent Apoptosis.
Li T, Zhao G, Zhang T, Zhang Z, Chen X, Song J, Wang X, Li J, Huang L, Wen L, Li C, Zhao D, He X, Bu Z, Zheng J, Weng C
Viruses 2021 Nov 8;13(11)
Viruses 2021 Nov 8;13(11)
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Lv Y, Ma P, Wang J, Xu Q, Fan J, Yan L, Ma P, Zhou R
European journal of pharmacology 2021 Nov 5;910:174311
European journal of pharmacology 2021 Nov 5;910:174311
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
Tβ4 ameliorates oxidative damage and apoptosis through ERK/MAPK and 5-HT1A signaling pathway in Aβ insulted SH-SY5Y cells.
Zhang GH, Pare RB, Chin KL, Qian YH
Life sciences 2021 Nov 25;:120178
Life sciences 2021 Nov 25;:120178
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Wang S, Wang A, Zhang Y, Zhu K, Wang X, Chen Y, Wu J
BMC endocrine disorders 2021 Nov 23;21(1):235
BMC endocrine disorders 2021 Nov 23;21(1):235
WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in Rats.
Zhu J, Lin X, Chen C, Tan H, Gao Y, Li D, Chen G
Neuroscience 2021 Nov 21;477:76-88
Neuroscience 2021 Nov 21;477:76-88
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.
Li M, Cheng W, Zhang L
Metallomics : integrated biometal science 2021 Nov 19;13(11)
Metallomics : integrated biometal science 2021 Nov 19;13(11)
Verapamil ameliorates proximal tubular epithelial cells apoptosis and fibrosis in diabetic kidney.
Song Y, Guo F, Zhao Y, Zhao L, Fan X, Zhang Y, Liu Y, Qin G
European journal of pharmacology 2021 Nov 15;911:174552
European journal of pharmacology 2021 Nov 15;911:174552
3-Epipachysamine B suppresses proliferation and induces apoptosis of breast cancer cell via PI3K/AKT/mTOR signaling pathway.
Zhang L, Zheng Y, Zeng L, Zhang F, Che D, Cao Z, Huang C, Xian L, Zhang X, Zhang H, Guo Z
Life sciences 2021 Nov 15;285:119995
Life sciences 2021 Nov 15;285:119995
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
Xi H, Ren F, Li Y, Du Y, Wang L, Hu J
Biology of reproduction 2021 Nov 15;105(5):1344-1354
Biology of reproduction 2021 Nov 15;105(5):1344-1354
Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.
Zhang S, Liu W, Wang P, Hu B, Lv X, Chen S, Wang B, Shao Z
Molecular and cellular biochemistry 2021 May;476(5):1979-1994
Molecular and cellular biochemistry 2021 May;476(5):1979-1994
TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.
Kong L, Yu Y, Guan H, Jiang L, Sun F, Li X, Huang W, Li B
International journal of molecular medicine 2021 May;47(5)
International journal of molecular medicine 2021 May;47(5)
The biological characteristics of the canine adenovirus type 1 from fox and the transcriptome analysis of the infected MDCK cell.
Zhu Y, Sun J, Yan M, Lian S, Hu B, Lv S, Li Y, Zhang Y, Yan X
Cell biology international 2021 May;45(5):936-947
Cell biology international 2021 May;45(5):936-947
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF
Acta pharmacologica Sinica 2021 May;42(5):691-700
Acta pharmacologica Sinica 2021 May;42(5):691-700
TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
Zhong BR, Zhou GF, Song L, Wen QX, Deng XJ, Ma YL, Hu LT, Chen GJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21445
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21445
IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway.
Huang N, Cui X, Li W, Zhang C, Liu L, Li J
Molecular medicine reports 2021 May;23(5)
Molecular medicine reports 2021 May;23(5)
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Wang HL, Xing GD, Qian Y, Sun XF, Zhong JF, Chen KL
Ecotoxicology and environmental safety 2021 May;214:112078
Ecotoxicology and environmental safety 2021 May;214:112078
Chlorogenic acid enhances autophagy by upregulating lysosomal function to protect against SH-SY5Y cell injury induced by H(2)O(2).
Gao LJ, Dai Y, Li XQ, Meng S, Zhong ZQ, Xu SJ
Experimental and therapeutic medicine 2021 May;21(5):426
Experimental and therapeutic medicine 2021 May;21(5):426
Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer.
Wu L, Wan S, Li J, Xu Y, Lou X, Sun M, Wang S
Oncology letters 2021 May;21(5):411
Oncology letters 2021 May;21(5):411
Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome.
Xu S, Jiang N, Nawaz W, Liu B, Zhang F, Liu Y, Wu X, Wu Z
PLoS pathogens 2021 May;17(5):e1009587
PLoS pathogens 2021 May;17(5):e1009587
Effects of SPATA6 on proliferation, apoptosis and steroidogenesis of Hu sheep Leydig cells in vitro.
Li X, Yao X, Xie H, Deng M, Gao X, Deng K, Bao Y, Wang Q, Wang F
Theriogenology 2021 May;166:9-20
Theriogenology 2021 May;166:9-20
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.
Wang YL, Lee YH, Hsu YH, Chiu IJ, Huang CC, Huang CC, Chia ZC, Lee CP, Lin YF, Chiu HW
Environmental health perspectives 2021 May;129(5):57003
Environmental health perspectives 2021 May;129(5):57003
Chloroquine enhances catalpol's ability to promote apoptosis by inhibiting catalpol's autophagy-promoting effect on gastric cancer.
Sun F, Wang Z, Wang X
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2021 May-Jun;26(3):924-931
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2021 May-Jun;26(3):924-931
LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
Huang Y, Lin Y, Song X, Wu D
Carcinogenesis 2021 May 28;42(5):733-741
Carcinogenesis 2021 May 28;42(5):733-741
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics.
Ding RB, Chen P, Rajendran BK, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong AH, Valecha MV, Yang EJ, Su SM, Choi TK, Liu S, Chan KI, Yang LL, Wu J, Miao K, Chen Q, Shim JS, Xu X, Deng CX
Nature communications 2021 May 24;12(1):3046
Nature communications 2021 May 24;12(1):3046
Dehydroabietic Acid Is a Novel Survivin Inhibitor for Gastric Cancer.
Kim WJ, Kim W, Bae JM, Gim J, Kim SJ
Plants (Basel, Switzerland) 2021 May 22;10(6)
Plants (Basel, Switzerland) 2021 May 22;10(6)
Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia.
Huang J, Zhang W, Zhang CL, Wang L
BMC cardiovascular disorders 2021 May 21;21(1):249
BMC cardiovascular disorders 2021 May 21;21(1):249
CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys.
Hou Y, Wang Q, Han B, Chen Y, Qiao X, Wang L
Cell death & disease 2021 May 21;12(6):523
Cell death & disease 2021 May 21;12(6):523
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566
Journal of hazardous materials 2021 May 15;410:124566
Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1.
Yao H, Shen H, Yu H, Wang C, Ding R, Lan X, Tash D, Wu X, Wang X, Zhang G
Physiology & behavior 2021 May 15;234:113387
Physiology & behavior 2021 May 15;234:113387
Protective effect of recombinant Lactobacillus plantarum against H(2)O(2)-induced oxidative stress in HUVEC cells.
Wang G, Hao M, Liu Q, Jiang Y, Huang H, Yang G, Wang C
Journal of Zhejiang University. Science. B 2021 May 15;22(5):348-365
Journal of Zhejiang University. Science. B 2021 May 15;22(5):348-365
Role of Glycated High Mobility Group Box-1 in Gastric Cancer.
Kishi S, Nishiguchi Y, Honoki K, Mori S, Fujiwara-Tani R, Sasaki T, Fujii K, Kawahara I, Goto K, Nakashima C, Kido A, Tanaka Y, Luo Y, Kuniyasu H
International journal of molecular sciences 2021 May 13;22(10)
International journal of molecular sciences 2021 May 13;22(10)
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257
Free radical biology & medicine 2021 May 1;167:243-257
Hsa_circ_0056558 regulates cyclin-dependent kinase 6 by sponging microRNA-1290 to suppress the proliferation and differentiation in ankylosing spondylitis.
Li X, Zhou W, Li Z, Guan F
Autoimmunity 2021 Mar;54(2):114-128
Autoimmunity 2021 Mar;54(2):114-128
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis.
Jiang Y, Nan H, Shi N, Hao W, Dong J, Chen H
Molecular biology reports 2021 Mar;48(3):2351-2364
Molecular biology reports 2021 Mar;48(3):2351-2364
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades.
Zhu S, Liu X, Xue M, Li Y, Cai D, Wang S, Zhang L
Journal of ginseng research 2021 Mar;45(2):295-304
Journal of ginseng research 2021 Mar;45(2):295-304
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Wang BN, Wu CB, Chen ZM, Zheng PP, Liu YQ, Xiong J, Xu JY, Li PF, Mamun AA, Ye LB, Zheng ZL, Wu YQ, Xiao J, Wang J
Acta pharmacologica Sinica 2021 Mar;42(3):347-360
Acta pharmacologica Sinica 2021 Mar;42(3):347-360
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury.
Lu S, Tian Y, Luo Y, Xu X, Ge W, Sun G, Sun X
Journal of advanced research 2021 Mar;29:83-94
Journal of advanced research 2021 Mar;29:83-94
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, Xue H, Wu M, Xu L
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K
British journal of pharmacology 2021 Mar;178(5):1182-1199
British journal of pharmacology 2021 Mar;178(5):1182-1199
CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro.
Yao X, Ei-Samahy MA, Xiao S, Wang Z, Meng F, Li X, Bao Y, Zhang Y, Wang Z, Fan Y, Wang F
Reproduction (Cambridge, England) 2021 Mar;161(3):255-267
Reproduction (Cambridge, England) 2021 Mar;161(3):255-267
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
Li H, Zhao K, Li Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
miR-98-5p protects against cerebral ischemia/reperfusion injury through anti-apoptosis and anti-oxidative stress in mice.
Yu S, Zhai J, Yu J, Yang Q, Yang J
Journal of biochemistry 2021 Mar 5;169(2):195-206
Journal of biochemistry 2021 Mar 5;169(2):195-206
The Phenoxyphenol Compound diTFPP Mediates Exogenous C(2)-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells.
Chang WT, Bow YD, Chen YC, Li CY, Chen JY, Chu YC, Teng YN, Li RN, Chiu CC
Antioxidants (Basel, Switzerland) 2021 Mar 5;10(3)
Antioxidants (Basel, Switzerland) 2021 Mar 5;10(3)
Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential.
Kim SY, Hwangbo H, Kim MY, Ji SY, Kim DH, Lee H, Kim GY, Moon SK, Leem SH, Yun SJ, Kim WJ, Cheong J, Park C, Choi YH
Molecules (Basel, Switzerland) 2021 Mar 4;26(5)
Molecules (Basel, Switzerland) 2021 Mar 4;26(5)
HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia.
Gao J, Feng W, Lv W, Liu W, Fu C
International heart journal 2021 Mar 30;62(2):350-358
International heart journal 2021 Mar 30;62(2):350-358
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.
Zhang X, Lu J, Zhang Q, Luo Q, Liu B
Biological research 2021 Mar 23;54(1):11
Biological research 2021 Mar 23;54(1):11
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Mar 17;70(1):67-78
Physiological research 2021 Mar 17;70(1):67-78
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease.
Zhang X, Li J, Ma L, Xu H, Cao Y, Liang W, Ma J, Wang ZP, Li Y
Cell death discovery 2021 Mar 15;7(1):51
Cell death discovery 2021 Mar 15;7(1):51
The Effect of Hispidulin, a Flavonoid from Salvia plebeia, on Human Nasopharyngeal Carcinoma CNE-2Z Cell Proliferation, Migration, Invasion, and Apoptosis.
Dai Y, Sun X, Li B, Ma H, Wu P, Zhang Y, Zhu M, Li HM, Qin M, Wu CZ
Molecules (Basel, Switzerland) 2021 Mar 14;26(6)
Molecules (Basel, Switzerland) 2021 Mar 14;26(6)
α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo.
Gu T, Yuan W, Li C, Chen Z, Wen Y, Zheng Q, Yang Q, Xiong X, Yuan A
Toxins 2021 Mar 13;13(3)
Toxins 2021 Mar 13;13(3)
Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids facilitates the repair of cardiotoxin-induced skeletal muscle injury in fat-1 mice.
Wang ZG, Zhu ZQ, He ZY, Cheng P, Liang S, Chen AM, Yang Q
Aging 2021 Mar 10;13(6):8454-8466
Aging 2021 Mar 10;13(6):8454-8466
Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells.
Wang X, Qiao J, Zou C, Zhao Y, Huang Y
Anti-cancer drugs 2021 Mar 1;32(3):248-256
Anti-cancer drugs 2021 Mar 1;32(3):248-256
Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-κB/MAPK signaling pathways.
Pan J, Chen S, Guo W, Cao S, Shi X, Zhang J, Zhang H, Zhang S
International immunopharmacology 2021 Jun;95:107527
International immunopharmacology 2021 Jun;95:107527
WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling.
Sun C, Ma Q, Yin J, Zhang H, Liu X
Experimental & molecular medicine 2021 Jun;53(6):1068-1079
Experimental & molecular medicine 2021 Jun;53(6):1068-1079
Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma.
Dell'Anno I, Martin SA, Barbarino M, Melani A, Silvestri R, Bottaro M, Paolicchi E, Corrado A, Cipollini M, Melaiu O, Giordano A, Luzzi L, Gemignani F, Landi S
Investigational new drugs 2021 Jun;39(3):644-657
Investigational new drugs 2021 Jun;39(3):644-657
Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells.
He QZ, Zhu BQ, Xu XN, Zeng HC
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Journal of biochemical and molecular toxicology 2021 Jun;35(6):1-11
Temperature Variability Does Not Attenuate the Beneficial Effects of Therapeutic Hypothermia on Cellular Apoptosis and Endoplasmic Reticulum Stress in the Cerebral Cortex of a Swine Cardiac Arrest Model.
Zhang B, Gu Q, Chen X, You Y, Chen M, Qian Y, Chen Y, Yu W
Neurocritical care 2021 Jun;34(3):769-780
Neurocritical care 2021 Jun;34(3):769-780
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Dai JM, Guo WN, Tan YZ, Niu KW, Zhang JJ, Liu CL, Yang XM, Tao KS, Chen ZN, Dai JY
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
RAS-association domain family 1A regulates the abnormal cell proliferation in psoriasis via inhibition of Yes-associated protein.
Jia J, Wang N, Zheng Y, Mo X, Zhang Y, Ye S, Liu J, Yan F, Li H, Chen D
Journal of cellular and molecular medicine 2021 Jun;25(11):5070-5081
Journal of cellular and molecular medicine 2021 Jun;25(11):5070-5081
SEC61G is upregulated and required for tumor progression in human kidney cancer.
Meng H, Jiang X, Wang J, Sang Z, Guo L, Yin G, Wang Y
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.
Yin Y, Qu L, Zhu D, Wu Y, Zhou X
Translational pediatrics 2021 Jun;10(6):1637-1646
Translational pediatrics 2021 Jun;10(6):1637-1646
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
Oshima Y, Cartier E, Boyman L, Verhoeven N, Polster BM, Huang W, Kane M, Lederer WJ, Karbowski M
The Journal of cell biology 2021 Jun 7;220(6)
The Journal of cell biology 2021 Jun 7;220(6)
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Qiao X, Ma J, Knight T, Su Y, Edwards H, Polin L, Li J, Kushner J, Dzinic SH, White K, Wang J, Lin H, Wang Y, Wang L, Wang G, Taub JW, Ge Y
Blood cancer journal 2021 Jun 7;11(6):111
Blood cancer journal 2021 Jun 7;11(6):111
Venlafaxine and L-Thyroxine Treatment Combination: Impact on Metabolic and Synaptic Plasticity Changes in an Animal Model of Coexisting Depression and Hypothyroidism.
Głombik K, Detka J, Budziszewska B
Cells 2021 Jun 5;10(6)
Cells 2021 Jun 5;10(6)
Anti-tumor effects of Solanum nigrum L. extraction on C6 high-grade glioma.
Li JH, Li SY, Shen MX, Qiu RZ, Fan HW, Li YB
Journal of ethnopharmacology 2021 Jun 28;274:114034
Journal of ethnopharmacology 2021 Jun 28;274:114034
DNA methylation mediated RSPO2 to promote follicular development in mammals.
Zhou X, He Y, Li N, Bai G, Pan X, Zhang Z, Zhang H, Li J, Yuan X
Cell death & disease 2021 Jun 26;12(7):653
Cell death & disease 2021 Jun 26;12(7):653
Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity.
Li P, Xia Z, Kong W, Wang Q, Zhao Z, Arnold A, Xu Q, Xu J
Nutrition & metabolism 2021 Jun 24;18(1):65
Nutrition & metabolism 2021 Jun 24;18(1):65
TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression.
Zhang X, Zhao S, Yuan Q, Zhu L, Li F, Wang H, Kong D, Hao J
Cell death & disease 2021 Jun 23;12(7):642
Cell death & disease 2021 Jun 23;12(7):642
Hyper-O-GlcNAcylation impairs insulin response against reperfusion-induced myocardial injury and arrhythmias in obesity.
Jin L, Gao F, Jiang T, Liu B, Li C, Qin X, Zheng Q
Biochemical and biophysical research communications 2021 Jun 18;558:126-133
Biochemical and biophysical research communications 2021 Jun 18;558:126-133
Hollow PtCo alloy nanospheres as a high-Z and oxygen generating nanozyme for radiotherapy enhancement in non-small cell lung cancer.
Li S, Sun W, Luo Y, Gao Y, Jiang X, Yuan C, Han L, Cao K, Gong Y, Xie C
Journal of materials chemistry. B 2021 Jun 16;9(23):4643-4653
Journal of materials chemistry. B 2021 Jun 16;9(23):4643-4653
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway.
Tong Y, Kai J, Wang S, Yu Y, Xie S, Zheng H, Wang Y, Liu Y, Zhu K, Guan X, Guo L, Lu R
Cell death & disease 2021 Jun 16;12(7):621
Cell death & disease 2021 Jun 16;12(7):621
Neuroprotective effects of bone marrow Sca-1(+) cells against age-related retinal degeneration in OPTN E50K mice.
Liu X, Hou M, Zhang S, Zhao Y, Wang Q, Jiang M, Du M, Shao Z, Yuan H
Cell death & disease 2021 Jun 15;12(6):613
Cell death & disease 2021 Jun 15;12(6):613
The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS.
Jadhao M, Tsai EM, Yang HC, Chen YF, Liang SS, Wang TN, Teng YN, Huang HW, Wang LF, Chiu CC
Antioxidants (Basel, Switzerland) 2021 Jun 11;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 11;10(6)
Hyaluronic acid/polyethyleneimine nanoparticles loaded with copper ion and disulfiram for esophageal cancer.
Xu R, Zhang K, Liang J, Gao F, Li J, Guan F
Carbohydrate polymers 2021 Jun 1;261:117846
Carbohydrate polymers 2021 Jun 1;261:117846
Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats.
Wu CH, Tsai YC, Tsai TH, Kuo KL, Su YF, Chang CH, Lin CL
International journal of molecular sciences 2021 Jun 1;22(11)
International journal of molecular sciences 2021 Jun 1;22(11)
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Cao Q, Luo J, Xiong Y, Liu Z, Ye Q
International immunopharmacology 2021 Jul;96:107643
International immunopharmacology 2021 Jul;96:107643
Hippocampal alpha-synuclein mediates depressive-like behaviors.
Du T, Li G, Luo H, Pan Y, Xu Q, Ma K
Brain, behavior, and immunity 2021 Jul;95:226-237
Brain, behavior, and immunity 2021 Jul;95:226-237
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S
Oncology reports 2021 Jul;46(1)
Oncology reports 2021 Jul;46(1)
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
Fa J
Oncology letters 2021 Jul;22(1):524
Oncology letters 2021 Jul;22(1):524
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.
Zheng S, Ni J, Li Y, Lu M, Yao Y, Guo H, Jiao M, Jin T, Zhang H, Yuan A, Wang Z, Yang Y, Chen Z, Wu H, Hu W
Pharmacological research 2021 Jul;169:105685
Pharmacological research 2021 Jul;169:105685
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Yang M, Kuang M, Wang G, Ali I, Tang Y, Yang C, Li Y, Li L
Molecular immunology 2021 Jul;135:388-397
Molecular immunology 2021 Jul;135:388-397
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.
Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Yang Z, Zhang YY, Wang YD, Tian FM, Zhang L
Orthopaedic surgery 2021 Jul;13(5):1662-1672
Orthopaedic surgery 2021 Jul;13(5):1662-1672
Amyloid-β (25-35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice.
Zhu L, Lu F, Jia X, Yan Q, Zhang X, Mu P
Journal of chemical neuroanatomy 2021 Jul;114:101945
Journal of chemical neuroanatomy 2021 Jul;114:101945
Anti-CD19 mAb modified mesoporous titanium dioxide as exclusively targeting vector for efficient B-lymphoblastic leukemia therapy.
Li S, Zhang L, Li M, Huang J, Cui B, Jia J, Guo Z, Ma K, Cui C
Journal of pharmaceutical sciences 2021 Jul;110(7):2733-2742
Journal of pharmaceutical sciences 2021 Jul;110(7):2733-2742
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Yang X, Li X, Luo M, Li C, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Enteric glial cells exert neuroprotection from hyperglycemia-induced damage via Akt/GSK3β pathway.
Luo P, He WX, Li C, Chang MJ
Neuroreport 2021 Jul 7;32(10):875-881
Neuroreport 2021 Jul 7;32(10):875-881
Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients.
Zhou L, Chen Z, Wu Y, Lu H, Xin L
Cancer cell international 2021 Jul 7;21(1):357
Cancer cell international 2021 Jul 7;21(1):357
The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.
Liu C, Wang W, Li H, Liu J, Zhang P, Cheng Y, Qin X, Hu Y, Wei Y
Food & function 2021 Jul 7;12(13):6091-6101
Food & function 2021 Jul 7;12(13):6091-6101
Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress.
Shi H, Yu Y, Wang Y, Liu X, Yu Y, Li M, Zou Y, Chen R, Ge J
International heart journal 2021 Jul 30;62(4):900-909
International heart journal 2021 Jul 30;62(4):900-909
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress.
Cheng L, Chen T, Guo M, Liu P, Qiao X, Wei Y, She J, Li B, Xi W, Zhou J, Yuan Z, Wu Y, Liu J
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1689-1706
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1689-1706
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
Tang X, Chen Y, Luo H, Bian Q, Weng B, Yang A, Chu D, Ran M, Chen B
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198
Cell death discovery 2021 Jul 29;7(1):198
NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.
Shi C, Weng M, Zhu H, Guo Y, Xu D, Jin H, Wei B, Cao Z
Aging 2021 Jul 29;13(14):18298-18309
Aging 2021 Jul 29;13(14):18298-18309
The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.
Guo Y, Xiao Y, Guo H, Zhu H, Chen D, Wang J, Deng J, Lan J, Liu X, Zhang Q, Bai Y
Aging 2021 Jul 28;13(14):18545-18563
Aging 2021 Jul 28;13(14):18545-18563
A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.
Fu Y, Xin Z, Ling Z, Xie H, Xiao T, Shen X, Lin J, Xu L, Jiang H
Molecular medicine (Cambridge, Mass.) 2021 Jul 22;27(1):81
Molecular medicine (Cambridge, Mass.) 2021 Jul 22;27(1):81
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
Long noncoding RNA GAS5 accelerates diabetic wound healing and promotes lymphangiogenesis via miR-217/Prox1 axis.
He ZY, Huang MT, Cui X, Zhou ST, Wu Y, Zhang PH, Zhou J
Molecular and cellular endocrinology 2021 Jul 15;532:111283
Molecular and cellular endocrinology 2021 Jul 15;532:111283
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Du Y, Zheng Y
Life sciences 2021 Jul 15;277:119520
Life sciences 2021 Jul 15;277:119520
Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling.
Song C, Chen J, Li X, Yang R, Cao X, Zhou L, Zhou Y, Ying H, Zhang Q, Sun Y
International immunopharmacology 2021 Jan;90:107161
International immunopharmacology 2021 Jan;90:107161
Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling.
Huang X, Pan M, Du P, Chen Y, Zhang C, Lu W, Lin J
Annals of translational medicine 2021 Jan;9(2):122
Annals of translational medicine 2021 Jan;9(2):122
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.
Tang M, Xie X, Shi M, Xin W, Zheng G, Zhang Y, Zhang Z, Lian X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153383
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153383
BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2.
Zhu Z, Pan Q, Zhao W, Wu X, Yu S, Shen Q, Zhang J, Yue W, Peng S, Li N, Zhang S, Lei A, Hua J
Cell proliferation 2021 Jan;54(1):e12932
Cell proliferation 2021 Jan;54(1):e12932
Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway.
Sun HH, Feng XM, Wang JC, Cai J
Molecular and cellular biochemistry 2021 Jan;476(1):435-441
Molecular and cellular biochemistry 2021 Jan;476(1):435-441
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150
Oncology reports 2021 Jan;45(1):139-150
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Liu JY, Fu WQ, Zheng XJ, Li W, Ren LW, Wang JH, Yang C, Du GH
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
UHRF1 Knockdown Attenuates Cell Growth, Migration, and Invasion in Cutaneous Squamous Cell Carcinoma.
Li Q, Chu Z, Geng S
Cancer investigation 2021 Jan;39(1):84-97
Cancer investigation 2021 Jan;39(1):84-97
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, Liu J, Fan W, Yi K, Kang C, Wu J
Redox biology 2021 Jan;38:101792
Redox biology 2021 Jan;38:101792
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.
Zhou L, Wang S, Cao L, Ren X, Li Y, Shao J, Xu L
International journal of environmental health research 2021 Jan;31(1):34-44
International journal of environmental health research 2021 Jan;31(1):34-44
Evaluation of piggyBac-mediated anti-CD19 CAR-T cells after ex vivo expansion with aAPCs or magnetic beads.
Yang LR, Li L, Meng MY, Wang WJ, Yang SL, Zhao YY, Wang RQ, Gao H, Tang WW, Yang Y, Yang LL, Liao LW, Hou ZL
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700
Journal of cellular and molecular medicine 2021 Jan;25(2):686-700
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Wang P, Wang C, Liu C
Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
Guo Y, Xiao Y, Zhu H, Guo H, Zhou Y, Shentu Y, Zheng C, Chen C, Bai Y
Biochemical pharmacology 2021 Jan;183:114344
Biochemical pharmacology 2021 Jan;183:114344
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Jin J, Zhou M, Wang X, Liu M, Huang H, Yan F, Yu Z, Shu X, Huo X, Feng L, Zhang B, Huang S, Deng S, Wang C, Ma X
Fitoterapia 2021 Jan;148:104779
Fitoterapia 2021 Jan;148:104779
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
Long F, Shi H, Li P, Guo S, Ma Y, Wei S, Li Y, Gao F, Gao S, Wang M, Duan R, Wang X, Yang K, Sun W, Li X, Li J, Liu Q
Bone 2021 Jan;142:115686
Bone 2021 Jan;142:115686
G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer.
Zhao J, Fu X, Chen H, Min L, Sun J, Yin J, Guo J, Li H, Tang Z, Ruan Y, Wang X, Sun Y, Huang L
British journal of cancer 2021 Jan;124(2):425-436
British journal of cancer 2021 Jan;124(2):425-436
AG490 protects cerebral ischemia/reperfusion injury via inhibiting the JAK2/3 signaling pathway.
Fan L, Zhou L
Brain and behavior 2021 Jan;11(1):e01911
Brain and behavior 2021 Jan;11(1):e01911
A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis.
Wang Z, Chen X, Liu N, Shi Y, Liu Y, Ouyang L, Tam S, Xiao D, Liu S, Wen F, Tao Y
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):263-274
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):263-274
Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury.
Jin P, Li LH, Shi Y, Hu NB
Gene 2021 Jan 30;767:145075
Gene 2021 Jan 30;767:145075
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation.
Feng S, Qiu G, Yang L, Feng L, Fan X, Ren F, Huang K, Chen Y
Bioscience reports 2021 Jan 29;41(1)
Bioscience reports 2021 Jan 29;41(1)
miR-335-5p suppresses gastric cancer progression by targeting MAPK10.
Gao Y, Wang Y, Wang X, Zhao C, Wang F, Du J, Zhang H, Shi H, Feng Y, Li D, Yan J, Yao Y, Hu W, Ding R, Zhang M, Wang L, Huang C, Zhang J
Cancer cell international 2021 Jan 22;21(1):71
Cancer cell international 2021 Jan 22;21(1):71
Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments.
Li S, Liu M, Ma H, Jin Q, Ma Y, Wang C, Ren J, Liu G, Dai Y
Journal of ovarian research 2021 Jan 21;14(1):17
Journal of ovarian research 2021 Jan 21;14(1):17
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3.
Qin HL, Wang XJ, Yang BX, Du B, Yun XL
Chinese medical journal 2021 Jan 20;134(5):546-554
Chinese medical journal 2021 Jan 20;134(5):546-554
Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
Zheng X, Liu D
Life sciences 2021 Jan 15;265:118825
Life sciences 2021 Jan 15;265:118825
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice.
Liu L, Yan LN, Sui Z
Life sciences 2021 Jan 15;265:118744
Life sciences 2021 Jan 15;265:118744
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
Li L, Wang F, Zhang J, Wang K, De X, Li L, Zhang Y
Ecotoxicology and environmental safety 2021 Jan 15;208:111461
Ecotoxicology and environmental safety 2021 Jan 15;208:111461
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Jan 14;70(1)
Physiological research 2021 Jan 14;70(1)
LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.
Xu H, Miao X, Li X, Chen H, Zhang B, Zhou W
Cancer cell international 2021 Jan 12;21(1):51
Cancer cell international 2021 Jan 12;21(1):51
A "dual-guide" bioinspired drug delivery strategy of a macrophage-based carrier against postoperative triple-negative breast cancer recurrence.
Qiu Y, Ren K, Zhao W, Yu Q, Guo R, He J, Mei L, Liu Y, Tang J, Xu S, Li J, Wei J, Li M, Zhang Z, He Q
Journal of controlled release : official journal of the Controlled Release Society 2021 Jan 10;329:191-204
Journal of controlled release : official journal of the Controlled Release Society 2021 Jan 10;329:191-204
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback.
Shen L, Zhou L, Xia M, Lin N, Ma J, Dong D, Sun L
Experimental cell research 2021 Jan 1;398(1):112369
Experimental cell research 2021 Jan 1;398(1):112369
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
Zhou S, Zhang D, Guo J, Chen Z, Chen Y, Zhang J
Brain research 2021 Jan 1;1750:147156
Brain research 2021 Jan 1;1750:147156
Cigarette smoke induced neural tube defects by down-regulating noggin expression.
Yin C, Cai H, Yang D, Jian Y, Zhang J, Li Z, Wang D
Birth defects research 2021 Jan 1;113(1):5-13
Birth defects research 2021 Jan 1;113(1):5-13
Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.
Ahmad B, Gamallat Y, Su P, Husain A, Rehman AU, Zaky MY, Bakheet AMH, Tahir N, Xin Y, Liang W
Chemical biology & drug design 2021 Feb;97(2):266-272
Chemical biology & drug design 2021 Feb;97(2):266-272
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
Jiao Y, Zhao D, Gao F, Hu X, Hu X, Li M, Cui Y, Wei X, Xie C, Zhao Y, Gao Y
Journal of physiology and biochemistry 2021 Feb;77(1):47-61
Journal of physiology and biochemistry 2021 Feb;77(1):47-61
Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor-mediated mRNA decay.
Zhu H, Li J, Li Y, Zheng Z, Guan H, Wang H, Tao K, Liu J, Wang Y, Zhang W, Li C, Li J, Jia L, Bai W, Hu D
Science advances 2021 Feb;7(9)
Science advances 2021 Feb;7(9)
20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y
Cell proliferation 2021 Feb;54(2):e12964
Cell proliferation 2021 Feb;54(2):e12964
lncRNA NEAT1 ameliorates LPS‑induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome.
Dai W, Wang M, Wang P, Wen J, Wang J, Cha S, Xiao X, He Y, Shu R, Bai D
International journal of molecular medicine 2021 Feb;47(2):607-620
International journal of molecular medicine 2021 Feb;47(2):607-620
Curcumin Ameliorates Copper-Induced Neurotoxicity Through Inhibiting Oxidative Stress and Mitochondrial Apoptosis in SH-SY5Y Cells.
Xiang B, Li D, Chen Y, Li M, Zhang Y, Sun T, Tang S
Neurochemical research 2021 Feb;46(2):367-378
Neurochemical research 2021 Feb;46(2):367-378
Autophagy Induction Contributes to the Neuroprotective Impact of Intermittent Fasting on the Acutely Injured Spinal Cord.
Yuan W, He X, Morin D, Barrière G, Liu X, Li J, Zhu Y
Journal of neurotrauma 2021 Feb;38(3):373-384
Journal of neurotrauma 2021 Feb;38(3):373-384
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.
Zhu F, Li W, Zhou X, Chen X, Zheng M, Cui Y, Liu X, Guo X, Zhu H
Journal of cellular and molecular medicine 2021 Feb;25(4):2040-2051
Journal of cellular and molecular medicine 2021 Feb;25(4):2040-2051
Suppression of Sox4 protects against myocardial ischemic injury by reduction of cardiac apoptosis in mice.
Zhang L, Lv L, Zheng N, Li R, Yang R, Li T, Li Y, Liu Y, Luo H, Li X, Zhou Y, Shan H, Bai B, Liang H
Journal of cellular physiology 2021 Feb;236(2):1094-1104
Journal of cellular physiology 2021 Feb;236(2):1094-1104
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571
Experimental and molecular pathology 2021 Feb;118:104571
Yak milk-derived exosomal microRNAs regulate intestinal epithelial cells on proliferation in hypoxic environment.
Gao HN, Ren FZ, Wen PC, Xie LX, Wang R, Yang ZN, Li YX
Journal of dairy science 2021 Feb;104(2):1291-1303
Journal of dairy science 2021 Feb;104(2):1291-1303
Targeting MUC1-C reverses the cisplatin resistance of esophageal squamous cell carcinoma in vitro and in vivo.
Zhao YQ, Wu T, Wang LF, Yin B, Shi M, Jiang B, Gong-Sun X, Song XM, Liu XY
Translational cancer research 2021 Feb;10(2):645-655
Translational cancer research 2021 Feb;10(2):645-655
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Zhang Q, Chen W, Zhang B, Li C, Zhang X, Wang Q, Wang Y, Zhou Q, Li X, Shen XL
Toxicology 2021 Feb 28;450:152681
Toxicology 2021 Feb 28;450:152681
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
Wang C, Xu T, Lachance BB, Zhong X, Shen G, Xu T, Tang C, Jia X
Journal of neuroinflammation 2021 Feb 18;18(1):50
Journal of neuroinflammation 2021 Feb 18;18(1):50
Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9.
Yang Y, Zhang Y, Yang C, Fang F, Wang Y, Chang H, Chen Z, Chen P
Virology journal 2021 Feb 18;18(1):39
Virology journal 2021 Feb 18;18(1):39
Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.
Qin J, Qu S, Zhu K, Cheng Y, Pan G, Jing W, Liu X, Sun X, Liu L
Bioorganic & medicinal chemistry 2021 Feb 15;32:116003
Bioorganic & medicinal chemistry 2021 Feb 15;32:116003
RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer.
Lyu G, Su P, Hao X, Chen S, Ren S, Zhao Z, Gong Y, Liu Q, Shao C
Cancer biology & medicine 2021 Feb 15;18(1):120-138
Cancer biology & medicine 2021 Feb 15;18(1):120-138
Protective effect of procyanidin A-type dimers against H(2)O(2)-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway.
Yan F, Chen L, Chen W, Zhao L, Lu Q, Liu R
Life sciences 2021 Feb 1;266:118908
Life sciences 2021 Feb 1;266:118908
MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness.
Zhu D, Xiao Z, Wang Z, Hu B, Duan C, Zhu Z, Gao N, Zhu Y, Wang H
Journal of neurosurgery 2021 Feb 1;134(2):499-511
Journal of neurosurgery 2021 Feb 1;134(2):499-511
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Peng X, Hao M, Zhao Y, Cai Y, Chen X, Chen H, Zhang Y, Dong L, Liu X, Ding C, Liu W, Yang M, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Huang S, Tan Z, Cai J, Wang Z, Tian Y
Pharmaceutical biology 2021 Dec;59(1):584-593
Pharmaceutical biology 2021 Dec;59(1):584-593
Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene.
Zhou Y, Wei W, Shen J, Lu L, Lu T, Wang H, Xue X
Pharmaceutical biology 2021 Dec;59(1):513-524
Pharmaceutical biology 2021 Dec;59(1):513-524
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Lu C, Liu L, Chen S, Niu J, Li S, Xie W, Cheng X
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.
Zeng L, Li A, Zhang Z, Zhang F, Chen H, Wang Y, Ding X, Luo H
Inflammation 2021 Dec;44(6):2362-2376
Inflammation 2021 Dec;44(6):2362-2376
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
Chen Y, Tian Y, Jin G, Cui Z, Guo W, Zhang X, Liu X
Human & experimental toxicology 2021 Dec;40(12):2074-2086
Human & experimental toxicology 2021 Dec;40(12):2074-2086
AK003290 Protects Myocardial Cells Against Apoptosis and Promotes Cardiac Function Recovery Via miR-539-3p/ErbB4 Axis in Ischemic-Reperfusion Injury.
Tang Y, Tang Y, Xiang Y, Yan J, Guo K
DNA and cell biology 2021 Dec;40(12):1528-1538
DNA and cell biology 2021 Dec;40(12):1528-1538
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Sinapic acid attenuates muscle atrophy in streptozotocin-induced diabetic mice.
Xianchu L, Ming L, Changhao C, Beiwang D, Jingtao X
Iranian journal of basic medical sciences 2021 Dec;24(12):1695-1701
Iranian journal of basic medical sciences 2021 Dec;24(12):1695-1701
Danshensu derivative ADTM ameliorates CCl(4)‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis.
Jia S, Chen Q, Wu J, Yao X, Shao J, Cheng X, Zhang C, Cen D, Wang Y, Shen Z, Shan L, Yao X
Pathology, research and practice 2021 Dec;228:153656
Pathology, research and practice 2021 Dec;228:153656
RNF43 overexpression attenuates the Wnt/β-catenin signalling pathway to suppress tumour progression in cholangiocarcinoma.
Pangestu NS, Chueakwon P, Talabnin K, Khiaowichit J, Talabnin C
Oncology letters 2021 Dec;22(6):846
Oncology letters 2021 Dec;22(6):846
Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats.
Li Y, Zhang Y, Zhou X, Lei X, Li X, Wei L
Experimental and therapeutic medicine 2021 Dec;22(6):1451
Experimental and therapeutic medicine 2021 Dec;22(6):1451
Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway.
Wang H, Zheng B, Che K, Han X, Li L, Wang H, Liu Y, Shi J, Sun S
Experimental and therapeutic medicine 2021 Dec;22(6):1400
Experimental and therapeutic medicine 2021 Dec;22(6):1400
TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression.
Li W, Hu S, Tian C, Wan X, Yu W, Guo P, Zhao F, Hua C, Lu X, Xue G, Han S, Guo W, Wang D, Deng W
Free radical biology & medicine 2021 Dec;177:31-47
Free radical biology & medicine 2021 Dec;177:31-47
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.
Li X, Yao X, Xie H, Zhang G, Deng M, Deng K, Gao X, Bao Y, Li K, Wang F
Theriogenology 2021 Dec;176:149-162
Theriogenology 2021 Dec;176:149-162
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, Shi Q, Tian Y, Wang H, Jia L, Gao T, Li C, Guo W
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
miR-142-3p and HMGB1 Are Negatively Regulated in Proliferation, Apoptosis, Migration, and Autophagy of Cartilage Endplate Cells.
Wang B, Ji D, Xing W, Li F, Huang Z, Zheng W, Xue J, Zhu Y, Yang X
Cartilage 2021 Dec;13(2_suppl):592S-603S
Cartilage 2021 Dec;13(2_suppl):592S-603S
MicroRNA-506 has a suppressive effect on the tumorigenesis of nonsmall-cell lung cancer by regulating tubby-like protein 3.
Li ZH, Zhou JH, Chen SN, Pan L, Feng Y, Luo MQ, Li RX, Sun GL
Bioengineered 2021 Dec;12(2):10176-10186
Bioengineered 2021 Dec;12(2):10176-10186
Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury.
Xu J, Yu D, Bai X, Zhang P
Bioengineered 2021 Dec;12(1):6674-6686
Bioengineered 2021 Dec;12(1):6674-6686
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.
Zhang X, Du P, Luo K, Li Y, Liu Z, Wang W, Zeng C, Ye Q, Xiao Q
Bioengineered 2021 Dec;12(1):3737-3752
Bioengineered 2021 Dec;12(1):3737-3752
A novel circular RNA (hsa_circ_0059930)-mediated miRNA-mRNA axis in the lipopolysaccharide-induced acute lung injury model of MRC-5 cells.
Han J, Li S, Feng Y, He Y, Hong W, Ye Z
Bioengineered 2021 Dec;12(1):1739-1751
Bioengineered 2021 Dec;12(1):1739-1751
MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma.
Liu H, Chi Z, Jin H, Yang W
Bioengineered 2021 Dec;12(1):1611-1626
Bioengineered 2021 Dec;12(1):1611-1626
Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway.
Yu Q, Chen S, Tang H, Zhang X, Tao R, Yan Z, Shi J, Guo W, Zhang S
International immunopharmacology 2021 Dec;101(Pt B):108294
International immunopharmacology 2021 Dec;101(Pt B):108294
Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis.
Ge S, Jiang C, Li M, Cheng Z, Feng X
Cancer cell international 2021 Dec 4;21(1):650
Cancer cell international 2021 Dec 4;21(1):650
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.
Ma W, Qiu Z, Bai Z, Dai Y, Li C, Chen X, Song X, Shi D, Zhou Y, Pan Y, Liao Y, Liao M, Zhou Z
Molecular therapy. Nucleic acids 2021 Dec 3;26:678-693
Molecular therapy. Nucleic acids 2021 Dec 3;26:678-693
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y, Zhao L
Oncogenesis 2021 Dec 3;10(12):84
Oncogenesis 2021 Dec 3;10(12):84
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
Chi D, Wang D, Zhang M, Ma H, Chen F, Sun Y
Experimental cell research 2021 Dec 15;409(2):112914
Experimental cell research 2021 Dec 15;409(2):112914
Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury.
Chen C, Lu L, Zhu J, Gu X, Liu B, Li D, Chen G
Brain research 2021 Dec 15;1773:147685
Brain research 2021 Dec 15;1773:147685
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling.
Yin P, Li D, Zhao Q, Cai M, Wu Z, Shi Y, Su L
Cell death discovery 2021 Dec 14;7(1):391
Cell death discovery 2021 Dec 14;7(1):391
Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis.
Zhang LC, Wu XY, Yang RB, Chen F, Liu JH, Hu YY, Wu ZD, Wang LF, Sun X
World journal of gastroenterology 2021 Dec 14;27(46):7982-7994
World journal of gastroenterology 2021 Dec 14;27(46):7982-7994
TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension.
Cao X, Fang X, Guo M, Li X, He Y, Xie M, Xu Y, Liu X
Respiratory research 2021 Dec 14;22(1):312
Respiratory research 2021 Dec 14;22(1):312
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
Geng Y, Wang Y, Sun R, Kang X, Zhao H, Zhu M, Sun Y, Hu Y, Wang Z, Tian X, Zhao Y, Yao J
Toxicology and applied pharmacology 2021 Dec 1;432:115758
Toxicology and applied pharmacology 2021 Dec 1;432:115758
The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Wang Z, Zhang Y, Zhao C, Li Y, Hu X, Wu L, Chen M, Tong S
Cellular signalling 2021 Aug;84:110004
Cellular signalling 2021 Aug;84:110004
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Zhang Y, Peng X
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Molecular nutrition & food research 2021 Aug;65(15):e2001202
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.
Pei XD, He ZL, Yao HL, Xiao JS, Li L, Gu JZ, Shi PZ, Wang JH, Jiang LH
European journal of nutrition 2021 Aug;60(5):2781-2793
European journal of nutrition 2021 Aug;60(5):2781-2793
Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways.
Wang M, Li Y, Gao Y, Li Q, Cao Y, Shen Y, Chen P, Yan J, Li J
Reproduction in domestic animals = Zuchthygiene 2021 Aug;56(8):1066-1084
Reproduction in domestic animals = Zuchthygiene 2021 Aug;56(8):1066-1084
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Man S, Wu Z, Sun R, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
Zeng L, Zhang F, Zhang Z, Xu M, Xu Y, Liu Y, Xu H, Sun X, Sang M, Luo H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22822
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22822
Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway.
Deng H, Yu B, Li Y
Phytotherapy research : PTR 2021 Aug;35(8):4309-4323
Phytotherapy research : PTR 2021 Aug;35(8):4309-4323
ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy.
Gu C, Yang J, Luo Y, Ran D, Tan X, Xiang P, Fei H, Lu Y, Guo W, Tu Y, Liu X, Wang H
Experimental neurology 2021 Aug;342:113759
Experimental neurology 2021 Aug;342:113759
EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.
Wu W, Dong J, Gou H, Geng R, Yang X, Chen D, Xiang B, Zhang Z, Ren S, Chen L, Liu J
Journal of cellular and molecular medicine 2021 Aug;25(16):7913-7921
Journal of cellular and molecular medicine 2021 Aug;25(16):7913-7921
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
Liu J, Liu L, Han YS, Yi J, Guo C, Zhao HQ, Ling J, Wang YH
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B.
Wu C, Liu X, Li B, Sun G, Peng C, Xiang D
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Ozone induces tolerance against cardiomyocytes oxygen-glucose deprivation/reperfusion through inhibition of autophagy pathway.
Xu L, Zhu L, Liu P, Wu Z, Zou Z
Experimental and therapeutic medicine 2021 Aug;22(2):869
Experimental and therapeutic medicine 2021 Aug;22(2):869
Emodin ameliorates acute pancreatitis-induced lung injury by suppressing NLRP3 inflammasome-mediated neutrophil recruitment.
Jiang N, Li Z, Luo Y, Jiang L, Zhang G, Yang Q, Chen H
Experimental and therapeutic medicine 2021 Aug;22(2):857
Experimental and therapeutic medicine 2021 Aug;22(2):857
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Zhou X, Zhang T, Song L, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhang W, Song N, Wang S
Ecotoxicology and environmental safety 2021 Aug;219:112323
Ecotoxicology and environmental safety 2021 Aug;219:112323
Vitamin E and selenium supplementation synergistically alleviate the injury induced by hydrogen peroxide in bovine granulosa cells.
Wang M, Li Y, Molenaar A, Li Q, Cao Y, Shen Y, Chen P, Yan J, Gao Y, Li J
Theriogenology 2021 Aug;170:91-106
Theriogenology 2021 Aug;170:91-106
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, Tan K
Molecular oncology 2021 Aug;15(8):2084-2105
Molecular oncology 2021 Aug;15(8):2084-2105
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
Xianjun F, Xirui X, Jie T, Huiwen M, Shaojun Z, Qiaoyun L, Yunxin L, Xuqun S
Journal of pharmacological sciences 2021 Aug;146(4):249-258
Journal of pharmacological sciences 2021 Aug;146(4):249-258
CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.
Shi Z, Wu D, Xu H, Yang J, Sun X
FEBS open bio 2021 Aug;11(8):2245-2255
FEBS open bio 2021 Aug;11(8):2245-2255
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Tian L, Wang S, Zhao L, Lu X, Zhu C, Gong H, Yang W
FEBS open bio 2021 Aug;11(8):2236-2244
FEBS open bio 2021 Aug;11(8):2236-2244
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.
Wang HX, Zhang R, Li Z, Wang LS, Yu Y, Wang Q, Ding Z, Zhang JP, Zhang MR, Xu LC
Toxicology research 2021 Aug;10(4):742-750
Toxicology research 2021 Aug;10(4):742-750
Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.
Yao C, Zhou Y, Wang H, Deng F, Chen Y, Zhu X, Kong Y, Pan L, Xue L, Zhou X, Shi C, Sheng X
Stem cell research & therapy 2021 Aug 9;12(1):447
Stem cell research & therapy 2021 Aug 9;12(1):447
Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway.
Wang Z, Zhao G, Zibrila AI, Li Y, Liu J, Feng W
Molecular human reproduction 2021 Aug 7;27(8)
Molecular human reproduction 2021 Aug 7;27(8)
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Chen X, Zhang W, Xu X
World journal of surgical oncology 2021 Aug 6;19(1):232
World journal of surgical oncology 2021 Aug 6;19(1):232
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
The screening of drug-induced nephrotoxicity using gold nanocluster-based ratiometric fluorescent probes.
Liu Q, Li J, Liu X, Yuan L, Zhao L, Chang YT, Liu X, Peng J
Nanoscale 2021 Aug 28;13(32):13835-13844
Nanoscale 2021 Aug 28;13(32):13835-13844
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J, Zhong C
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Zhang Z, Li Z, Wang Y, Wang Q, Yao M, Zhao L, Shi J, Guan F, Ma S
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189
Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice.
Huang L, Chen R, Liu L, Zhou Y, Chen Z
Food & function 2021 Aug 21;12(16):7514-7526
Food & function 2021 Aug 21;12(16):7514-7526
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Cheng Z, Lv D, Luo M, Wang R, Guo Y, Yang X, Huang L, Li X, Li C, Shang FF, Huang B, Shen J, Luo S, Yan J
European journal of pharmacology 2021 Aug 15;905:174186
European journal of pharmacology 2021 Aug 15;905:174186
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Xiaoli F, Yaqing Z, Ruhui L, Xuan L, Aijie C, Yanli Z, Chen H, Lili C, Longquan S
Journal of hazardous materials 2021 Aug 15;416:126158
Journal of hazardous materials 2021 Aug 15;416:126158
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Zhou S, He Y, Zhang W, Xiong Y, Jiang L, Wang J, Cui X, Qu Y, Ge F
Journal of ethnopharmacology 2021 Aug 10;276:114189
Journal of ethnopharmacology 2021 Aug 10;276:114189
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway.
Wang Z, Liu L, Dai H, Si X, Zhang L, Li E, Yang Z, Chao G, Zheng J, Ke Y, Lihong S, Zhang Q, Liu H
Bioorganic & medicinal chemistry 2021 Aug 1;43:116265
Bioorganic & medicinal chemistry 2021 Aug 1;43:116265
Knockdown of enhancer of rudimentary homolog expression attenuates proliferation, cell cycle and apoptosis of melanoma cells.
Xiao M, Tang N, Yan Y, Li Z, Shi S, He S, Chen Z, Cao K, Chen J, Zhou J, Chen X
Melanoma research 2021 Aug 1;31(4):309-318
Melanoma research 2021 Aug 1;31(4):309-318
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Fan H, Ding R, Liu W, Zhang X, Li R, Wei B, Su S, Jin F, Wei C, He X, Li X, Duan C
Redox biology 2021 Apr;40:101856
Redox biology 2021 Apr;40:101856
Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells.
Zhao S, Tang L, Chen W, Su J, Li F, Chen X, Wu L
Naunyn-Schmiedeberg's archives of pharmacology 2021 Apr;394(4):797-807
Naunyn-Schmiedeberg's archives of pharmacology 2021 Apr;394(4):797-807
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Luo L, Jian X, Sun H, Qin J, Wang Y, Zhang J, Shen Z, Yang D, Li C, Zhao P, Liu M, Tian Z, Zhou Y
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Ji Q, Qiao X, Liu Y, Wang D
Histology and histopathology 2021 Apr;36(4):475-484
Histology and histopathology 2021 Apr;36(4):475-484
Coaction of hepatic thioredoxin and glutathione systems in iron overload-induced oxidative stress.
Sönmez Aydın F, Hukkamlı B, Budak H
Journal of biochemical and molecular toxicology 2021 Apr;35(4):e22704
Journal of biochemical and molecular toxicology 2021 Apr;35(4):e22704
CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.
Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W
Cell death and differentiation 2021 Apr;28(4):1347-1363
Cell death and differentiation 2021 Apr;28(4):1347-1363
Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation.
Liu X, Gu Y, Bian Y, Cai D, Li Y, Zhao Y, Zhang Z, Xue M, Zhang L
Apoptosis : an international journal on programmed cell death 2021 Apr;26(3-4):195-208
Apoptosis : an international journal on programmed cell death 2021 Apr;26(3-4):195-208
Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.
Da J, Wang X, Li L, Xu Y
The Tohoku journal of experimental medicine 2021 Apr;253(4):249-259
The Tohoku journal of experimental medicine 2021 Apr;253(4):249-259
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Liu K, Yang W, Hu M, Xie W, Huang J, Cui M, He X, Nie X
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Elevated Secretion of Aldosterone Increases TG/HDL-C Ratio and Potentiates The Ox-LDL-Induced Dysfunction of HUVEC.
Zhang Q, Pan Y, Ma X, Yang H, Chang J, Hong L, Yan H, Zhang SH
Cell journal 2021 Apr;23(1):61-69
Cell journal 2021 Apr;23(1):61-69
The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells.
Yang B, Zang J, Yuan W, Jiang X, Zhang F
Experimental and therapeutic medicine 2021 Apr;21(4):317
Experimental and therapeutic medicine 2021 Apr;21(4):317
Morroniside protects OLN-93 cells against H(2)O(2)-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities.
Li F, Song X, Xu J, Shi Y, Hu R, Ren Z, Qi Q, Lü H, Cheng X, Hu J
Cell cycle (Georgetown, Tex.) 2021 Apr;20(7):661-675
Cell cycle (Georgetown, Tex.) 2021 Apr;20(7):661-675
Salidroside Attenuates Doxorubicin-Induced Cardiac Dysfunction Partially Through Activation of QKI/FoxO1 Pathway.
Yan F, Liu R, Zhuang X, Li R, Shi H, Gao X
Journal of cardiovascular translational research 2021 Apr;14(2):355-364
Journal of cardiovascular translational research 2021 Apr;14(2):355-364
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
Wang ZD, Feng Y, Sun L, Gan J, Li X, Ding WF, Chen XM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
Preclinical Evaluation of Recombinant Human IL15 Protein Fused with Albumin Binding Domain on Anti-PD-L1 Immunotherapy Efficiency and Anti-Tumor Immunity in Colon Cancer and Melanoma.
Hsu FT, Liu YC, Tsai CL, Yueh PF, Chang CH, Lan KL
Cancers 2021 Apr 9;13(8)
Cancers 2021 Apr 9;13(8)
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation.
Huang Y, Sun X, Juan Z, Zhang R, Wang R, Meng S, Zhou J, Li Y, Xu K, Xie K
BMC anesthesiology 2021 Apr 6;21(1):104
BMC anesthesiology 2021 Apr 6;21(1):104
Mild hypothermia pretreatment extenuates liver ischemia-reperfusion injury through Rab7-mediated autophagosomes-lysosomes fusion.
Liu A, Wang W, Lu Z, Liu Z, Zhou W, Zhong Z, Ye Q
Biochemical and biophysical research communications 2021 Apr 23;550:15-21
Biochemical and biophysical research communications 2021 Apr 23;550:15-21
Coibamide A kills cancer cells through inhibiting autophagy.
Shi W, Lu D, Wu C, Li M, Ding Z, Li Y, Chen B, Lin X, Su W, Shao X, Xia Z, Fang L, Liu K, Li H
Biochemical and biophysical research communications 2021 Apr 2;547:52-58
Biochemical and biophysical research communications 2021 Apr 2;547:52-58
CSF-CN contributes to cancer-induced bone pain via the MKP-1-mediated MAPK pathway.
Chen P, Pan M, Lin QS, Lin XZ, Lin Z
Biochemical and biophysical research communications 2021 Apr 2;547:36-43
Biochemical and biophysical research communications 2021 Apr 2;547:36-43
Inhibition of Notch1 signaling reduces hepatocyte injury in nonalcoholic fatty liver disease via autophagy.
Zhang M, Wu P, Li M, Guo Y, Tian T, Liao X, Tan S
Biochemical and biophysical research communications 2021 Apr 2;547:131-138
Biochemical and biophysical research communications 2021 Apr 2;547:131-138
Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway.
He X, Guo X, Ma Z, Li Y, Kang J, Zhang G, Gao Y, Liu M, Chen H, Kang X
Neuroscience letters 2021 Apr 17;750:135793
Neuroscience letters 2021 Apr 17;750:135793
Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury.
Quan X, Song L, Zheng X, Liu S, Ding H, Li S, Xu G, Li X, Liu L
Neuroscience 2021 Apr 15;460:107-119
Neuroscience 2021 Apr 15;460:107-119
Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma.
Chen Z, Gao Y, Huang X, Yao Y, Chen K, Zeng S, Mao W
Journal of pharmaceutical and biomedical analysis 2021 Apr 15;197:113937
Journal of pharmaceutical and biomedical analysis 2021 Apr 15;197:113937
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396
BMC cancer 2021 Apr 12;21(1):396
Sodium propionate protect the blood-milk barrier integrity, relieve lipopolysaccharide-induced inflammatory injury and cells apoptosis.
Ali I, Yang M, Wang Y, Yang C, Shafiq M, Wang G, Li L
Life sciences 2021 Apr 1;270:119138
Life sciences 2021 Apr 1;270:119138
Macrophages-derived exosomal lncRNA LIFR-AS1 promotes osteosarcoma cell progression via miR-29a/NFIA axis.
Zhang H, Yu Y, Wang J, Han Y, Ren T, Huang Y, Chen C, Huang Q, Wang W, Niu J, Lou J, Guo W
Cancer cell international 2021 Apr 1;21(1):192
Cancer cell international 2021 Apr 1;21(1):192
Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer.
Fouladian P, Jin Q, Arafat M, Song Y, Guo X, Blencowe A, Garg S
Pharmaceuticals (Basel, Switzerland) 2021 Apr 1;14(4)
Pharmaceuticals (Basel, Switzerland) 2021 Apr 1;14(4)
Inhibiting Heat Shock Protein 90 Protects Nucleus Pulposus-Derived Stem/Progenitor Cells From Compression-Induced Necroptosis and Apoptosis.
Hu B, Zhang S, Liu W, Wang P, Chen S, Lv X, Shi D, Ma K, Wang B, Wu Y, Shao Z
Frontiers in cell and developmental biology 2020;8:685
Frontiers in cell and developmental biology 2020;8:685
PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis.
Guo Q, Ke XX, Fang SX, Gao WL, Song YX, Chen C, Lu HL, Xu G
Frontiers in cell and developmental biology 2020;8:581919
Frontiers in cell and developmental biology 2020;8:581919
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Xu WN, Yang RZ, Zheng HL, Jiang LS, Jiang SD
Frontiers in cell and developmental biology 2020;8:515051
Frontiers in cell and developmental biology 2020;8:515051
miR-214 Protects Against Uric Acid-Induced Endothelial Cell Apoptosis.
Yang B, Li S, Zhu J, Huang S, Zhang A, Jia Z, Ding G, Zhang Y
Frontiers in medicine 2020;7:411
Frontiers in medicine 2020;7:411
miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL.
Majid A, Wang J, Nawaz M, Abdul S, Ayesha M, Guo C, Liu Q, Liu S, Sun MZ
Frontiers in molecular biosciences 2020;7:223
Frontiers in molecular biosciences 2020;7:223
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
Feng B, Zhao C, Li J, Yu J, Zhang Y, Zhang X, Tian T, Zhao L
Chemical & pharmaceutical bulletin 2020;68(10):962-970
Chemical & pharmaceutical bulletin 2020;68(10):962-970
RGS12 is required for the maintenance of mitochondrial function during skeletal development.
Yuan G, Yang S, Liu M, Yang S
Cell discovery 2020;6:59
Cell discovery 2020;6:59
Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice.
Wang Q, Zhao Y, Zang B
Acta cirurgica brasileira 2020;35(2):e202000204
Acta cirurgica brasileira 2020;35(2):e202000204
Shenmai Injection Supresses Glycolysis and Enhances Cisplatin Cytotoxicity in Cisplatin-Resistant A549/DDP Cells via the AKT-mTOR-c-Myc Signaling Pathway.
Sun Y, Chen Y, Xu M, Liu C, Shang H, Wang C
BioMed research international 2020;2020:9243681
BioMed research international 2020;2020:9243681
Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro.
Li D, Pei X, Qin X, Liu X, Li C, Li L, Dai C, Xiao X, Tang S
Oxidative medicine and cellular longevity 2020;2020:8835207
Oxidative medicine and cellular longevity 2020;2020:8835207
Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.
Cui R, Liu S, Wang C, Liu T, Ren J, Jia Y, Tong Y, Liu C, Zhang J
Oxidative medicine and cellular longevity 2020;2020:8829328
Oxidative medicine and cellular longevity 2020;2020:8829328
Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy.
Zhang S, Yuan Z, Wu H, Li W, Li L, Huang H
BioMed research international 2020;2020:8260703
BioMed research international 2020;2020:8260703
Astaxanthin Protects Ochratoxin A-Induced Oxidative Stress and Apoptosis in the Heart via the Nrf2 Pathway.
Cui G, Li L, Xu W, Wang M, Jiao D, Yao B, Xu K, Chen Y, Yang S, Long M, Li P, Guo Y
Oxidative medicine and cellular longevity 2020;2020:7639109
Oxidative medicine and cellular longevity 2020;2020:7639109
Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model.
Zhang J, Wang Y, Ju M, Song J, Zheng Y, Lin S, Zhu D, Wen L, Zhong M, Pan S, Yang G
Oxidative medicine and cellular longevity 2020;2020:7468738
Oxidative medicine and cellular longevity 2020;2020:7468738
Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.
Li T, Li S, Feng Y, Zeng X, Dong S, Li J, Zha L, Luo H, Zhao L, Liu B, Ou Z, Lin W, Zhang M, Li S, Jiang Q, Qi Q, Xu Q, Yu Z
Oxidative medicine and cellular longevity 2020;2020:6973636
Oxidative medicine and cellular longevity 2020;2020:6973636
Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis.
Deng Y, Yang L, Xie Q, Yang F, Li G, Zhang G, Li S, Wu Z, Wang J, Kang X
Mediators of inflammation 2020;2020:6420425
Mediators of inflammation 2020;2020:6420425
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
Gao Y, Zheng H, Li L, Zhou C, Chen X, Zhou X, Cao Y
BioMed research international 2020;2020:6349312
BioMed research international 2020;2020:6349312
Berberine Suppressed Tumor Growth through Regulating Fatty Acid Metabolism and Triggering Cell Apoptosis via Targeting FABPs.
Li L, Peng Z, Hu Q, Xu L, Zou X, Yu Y, Huang D, Yi P
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6195050
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6195050
Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.
Wang W, Hu X, Xia Z, Liu Z, Zhong Z, Lu Z, Liu A, Ye S, Cao Q, Wang Y, Zhu F, Ye Q
Oxidative medicine and cellular longevity 2020;2020:5849794
Oxidative medicine and cellular longevity 2020;2020:5849794
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
Xue W, Liu Y, Xin N, Miao J, Du J, Wang Y, Shi H, Wei Y, Zhang H, Chen Y, Gao Y, Li D, Feng Y, Yan J, Zhang J, Hou N, Huang C, Han J
BioMed research international 2020;2020:5053975
BioMed research international 2020;2020:5053975
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Deng X, Lin N, Fu J, Xu L, Luo H, Jin Y, Liu Y, Sun L, Su J
Oxidative medicine and cellular longevity 2020;2020:4830418
Oxidative medicine and cellular longevity 2020;2020:4830418
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
UFM1-Specific Ligase 1 Ligating Enzyme 1 Mediates Milk Protein and Fat Synthesis-Related Gene Expression via the JNK Signaling Pathway in Mouse Mammary Epithelial Cells.
Kuang M, Yang M, Li L, Li C, Wang G
Oxidative medicine and cellular longevity 2020;2020:4045674
Oxidative medicine and cellular longevity 2020;2020:4045674
Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway.
Du LJ, Pang B, Tan YM, Yang YN, Zhang MZ, Pang Q, Sun M, Ni Q
Journal of diabetes research 2020;2020:3695689
Journal of diabetes research 2020;2020:3695689
Overexpression of BMPER in Ovarian Cancer and the Mechanism by which It Promotes Malignant Biological Behavior in Tumor Cells.
Xi Y, Nie X, Wang J, Gao L, Lin B
BioMed research international 2020;2020:3607436
BioMed research international 2020;2020:3607436
Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression.
Zhu XG, Zhang TN, Wen R, Liu CF
BioMed research international 2020;2020:3023186
BioMed research international 2020;2020:3023186
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Tian R, Jiang H, Shao L, Yu Y, Guo Q, Cao B, Guo S
BioMed research international 2020;2020:2863236
BioMed research international 2020;2020:2863236
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Kang D, Zuo W, Wu Q, Zhu Q, Liu P
BioMed research international 2020;2020:1358674
BioMed research international 2020;2020:1358674
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C
BioMed research international 2020;2020:1276328
BioMed research international 2020;2020:1276328
Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway.
Li C, Wang X, Yan J, Cheng F, Ma X, Chen C, Wang W, Wang Q
Oxidative medicine and cellular longevity 2020;2020:1201624
Oxidative medicine and cellular longevity 2020;2020:1201624
Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.
Shi C, Lan W, Wang Z, Yang D, Wei J, Liu Z, Teng Y, Gu M, Yuan T, Cao F, Zhou J, Li Y
Cancer cell international 2020;20:442
Cancer cell international 2020;20:442
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
Li K, Zhao S, Long J, Su J, Wu L, Tao J, Zhou J, Zhang J, Chen X, Peng C
Cancer cell international 2020;20:36
Cancer cell international 2020;20:36
A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.
Tang L, Long J, Li K, Zhang X, Chen X, Peng C
Cancer cell international 2020;20:256
Cancer cell international 2020;20:256
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, Zhao F
Cancer cell international 2020;20:237
Cancer cell international 2020;20:237
Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma.
Wang JX, Jia XJ, Liu Y, Dong JH, Ren XM, Xu O, Liu SH, Shan CG
Cancer cell international 2020;20:14
Cancer cell international 2020;20:14
Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway.
Wang MR, Fang D, Di MP, Guan JL, Wang G, Liu L, Sheng JQ, Tian DA, Li PY
International journal of medical sciences 2020;17(9):1224-1234
International journal of medical sciences 2020;17(9):1224-1234
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis.
Wang D, Qi H, Zhang H, Zhou W, Li Y, Li A, Liu Q, Wang Y
International journal of biological sciences 2020;16(7):1180-1193
International journal of biological sciences 2020;16(7):1180-1193
Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways.
Wei L, Zhou Q, Tian H, Su Y, Fu GH, Sun T
International journal of biological sciences 2020;16(4):644-654
International journal of biological sciences 2020;16(4):644-654
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158
International journal of biological sciences 2020;16(12):2145-2158
Septin4 promotes cell death in human colon cancer cells by interacting with BAX.
Zhao X, Feng H, Wang Y, Wu Y, Guo Q, Feng Y, Ma M, Guo W, Song X, Zhang Y, Han S, Cao L
International journal of biological sciences 2020;16(11):1917-1928
International journal of biological sciences 2020;16(11):1917-1928
The effect of autophagy and mitochondrial fission on Harderian gland is greater than apoptosis in male hamsters during different photoperiods.
Xu JH, Wang Z, Mou JJ, Zhao XY, Geng XC, Wu M, Xue HL, Chen L, Xu LX
PloS one 2020;15(11):e0241561
PloS one 2020;15(11):e0241561
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy.
Zhang Y, Huang N, Xu J, Zheng W, Cui X
Drug design, development and therapy 2020;14:4749-4763
Drug design, development and therapy 2020;14:4749-4763
Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis.
Zhang JA, Luan C, Huang D, Ju M, Chen K, Gu H
Drug design, development and therapy 2020;14:417-428
Drug design, development and therapy 2020;14:417-428
Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway.
Zeng Q, Che Y, Zhang Y, Chen M, Guo Q, Zhang W
Drug design, development and therapy 2020;14:2535-2547
Drug design, development and therapy 2020;14:2535-2547
Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1.
Ge J, Huang Y, Zhang Y, Liu L, Gu T, Liu X, Yao L, Cai M, Sun J, Song J
Drug design, development and therapy 2020;14:1561-1569
Drug design, development and therapy 2020;14:1561-1569
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Zhang X, Chen Y, Wang K, Tang J, Chen Y, Jin G, Liu X
International journal of clinical and experimental pathology 2020;13(9):2228-2239
International journal of clinical and experimental pathology 2020;13(9):2228-2239
URM1 Promoted Tumor Growth and Suppressed Apoptosis via the JNK Signaling Pathway in Hepatocellular Carcinoma.
Cheng X, Zhang Y, Song F, Song F, Gao C, Liang X, Wang F, Chen Z
OncoTargets and therapy 2020;13:8011-8025
OncoTargets and therapy 2020;13:8011-8025
Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
Ji D, Zheng W, Huang P, Yao Y, Zhong X, Kang P, Wang Z, Shi G, Xu Y, Cui Y
OncoTargets and therapy 2020;13:7819-7837
OncoTargets and therapy 2020;13:7819-7837
Derlin-1 Promotes the Progression of Human Hepatocellular Carcinoma via the Activation of AKT Pathway.
Fan J, Tian L, Huang S, Zhang J, Zhao B
OncoTargets and therapy 2020;13:5407-5417
OncoTargets and therapy 2020;13:5407-5417
β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways.
Su P, Ahmad B, Zou K, Zou L
OncoTargets and therapy 2020;13:5207-5222
OncoTargets and therapy 2020;13:5207-5222
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020;13:473-486
OncoTargets and therapy 2020;13:473-486
LncRNA MIR503HG Promotes High-Glucose-Induced Proximal Tubular Cell Apoptosis by Targeting miR-503-5p/Bcl-2 Pathway.
Cao X, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:4507-4517
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:4507-4517
Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.
Zhang C, Shao Z, Chen Z, Lin C, Hu S, Lou Z, Li J, Zheng X, Lin N, Gao W
American journal of translational research 2020;12(8):4781-4794
American journal of translational research 2020;12(8):4781-4794
Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways.
Wang CX, Xiong HF, Wang S, Wang J, Nie X, Guo Q, Li X, Qi Y, Liu JJ, Lin B
American journal of translational research 2020;12(7):3557-3576
American journal of translational research 2020;12(7):3557-3576
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Wei X, Wang H, Sun X, Huang X, Xu W, Liang Y, Liu L, Mo S, Lin X, Lin J
American journal of translational research 2020;12(5):2169-2180
American journal of translational research 2020;12(5):2169-2180
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Selaginellin B induces apoptosis and autophagy in pancreatic cancer cells via the JAK2/STAT3 signaling pathway.
Chu P, Wang S, Zhu X, Yang Y, Li H, Tesfaldet T, Shopit A, Yang Y, Ma X, Peng J, Tang Z, Sun Z
American journal of translational research 2020;12(11):7127-7143
American journal of translational research 2020;12(11):7127-7143
Caspase-8 knockdown suppresses apoptosis, while induces autophagy and chemo-sensitivity in non-small cell lung cancer cells.
Zuo H, Chen C, Ma L, Min QX, Shen YH
American journal of translational research 2020;12(10):6478-6489
American journal of translational research 2020;12(10):6478-6489
miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway.
Zhao J, Xu H, Duan Z, Chen X, Ao Z, Chen Y, Ruan Y, Ni M
Cancer management and research 2020;12:6679-6694
Cancer management and research 2020;12:6679-6694
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Yin Z, Wang X, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X, Zhang S
Frontiers in aging neuroscience 2020;12:582455
Frontiers in aging neuroscience 2020;12:582455
Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer.
Chang J, Hong L, Liu Y, Pan Y, Yang H, Ye W, Xu K, Li Z, Zhang S
Cancer management and research 2020;12:2641-2651
Cancer management and research 2020;12:2641-2651
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Xu F, Xu Y, Xiong JH, Zhang JH, Wu J, Luo J, Xiong JP
Cancer management and research 2020;12:1789-1798
Cancer management and research 2020;12:1789-1798
Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling.
Ping MH
Cancer management and research 2020;12:11773-11782
Cancer management and research 2020;12:11773-11782
Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth.
Guo Y, Wang C, Jiang M, Zhu H, Weng M, Sun L, Zhang Y
Cancer management and research 2020;12:11435-11444
Cancer management and research 2020;12:11435-11444
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Yang B, Bai H, Sa Y, Zhu P, Liu P
Journal of Cancer 2020;11(8):2303-2317
Journal of Cancer 2020;11(8):2303-2317
Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.
Zeng J, Chen S, Li C, Ye Z, Lin B, Liang Y, Wang B, Ma Y, Chai X, Zhang X, Zhou K, Zhang Q, Zhang H
Journal of Cancer 2020;11(8):2068-2079
Journal of Cancer 2020;11(8):2068-2079
Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells.
Zhang YY, Luo LM, Wang YX, Zhu N, Zhao TJ, Qin L
Journal of Cancer 2020;11(14):4261-4273
Journal of Cancer 2020;11(14):4261-4273
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Chen Z, Zhang C, Ma H, Huang Z, Li J, Lou J, Li B, Tu Q, Gao W
Frontiers in pharmacology 2020;11:951
Frontiers in pharmacology 2020;11:951
Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway.
Zhao M, Tang X, Gong D, Xia P, Wang F, Xu S
Frontiers in pharmacology 2020;11:71
Frontiers in pharmacology 2020;11:71
Long Noncoding RNA TCONS_00016406 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating the miR-687/PTEN Pathway.
Liu X, Zhu N, Zhang B, Xu SB
Frontiers in physiology 2020;11:622
Frontiers in physiology 2020;11:622
Induced Expression of kir6.2 in A1 Astrocytes Propagates Inflammatory Neurodegeneration via Drp1-dependent Mitochondrial Fission.
Song N, Zhu H, Xu R, Liu J, Fang Y, Zhang J, Ding J, Hu G, Lu M
Frontiers in pharmacology 2020;11:618992
Frontiers in pharmacology 2020;11:618992
Isorhamnetin Enhances the Radiosensitivity of A549 Cells Through Interleukin-13 and the NF-κB Signaling Pathway.
Du Y, Jia C, Liu Y, Li Y, Wang J, Sun K
Frontiers in pharmacology 2020;11:610772
Frontiers in pharmacology 2020;11:610772
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Hu J, Zhu Z, Ying H, Yao J, Ma H, Li L, Zhao Y
Frontiers in pharmacology 2020;11:605065
Frontiers in pharmacology 2020;11:605065
Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress.
Wang H, Xia W, Long G, Pei Z, Li Y, Wu M, Wang Q, Zhang Y, Jia Z, Chen H
Frontiers in pharmacology 2020;11:599416
Frontiers in pharmacology 2020;11:599416
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Li C, Zhang S, Li L, Hu Q, Ji S
Frontiers in pharmacology 2020;11:594496
Frontiers in pharmacology 2020;11:594496
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.
Pan B, Wang Y, Wu C, Jia J, Huang C, Fang S, Liu L
Frontiers in pharmacology 2020;11:592903
Frontiers in pharmacology 2020;11:592903
Amniotic Membrane Extract Protects Islets From Serum-Deprivation Induced Impairments and Improves Islet Transplantation Outcome.
Yang Z, Li X, Zhang C, Sun N, Guo T, Lin J, Li F, Zhang J
Frontiers in endocrinology 2020;11:587450
Frontiers in endocrinology 2020;11:587450
Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux.
He X, Yuan W, Liu F, Feng J, Guo Y
Frontiers in pharmacology 2020;11:586302
Frontiers in pharmacology 2020;11:586302
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Luo H, Peng F, Weng B, Tang X, Chen Y, Yang A, Chen B, Ran M
Frontiers in genetics 2020;11:581593
Frontiers in genetics 2020;11:581593
Salvianolic Acid B Protects Against Fatty Acid-Induced Renal Tubular Injury via Inhibition of Endoplasmic Reticulum Stress.
Mai X, Yin X, Chen P, Zhang M
Frontiers in pharmacology 2020;11:574229
Frontiers in pharmacology 2020;11:574229
Morroniside Inhibits H(2)O(2)-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro.
Gao X, Liu Y, Wang L, Sai N, Liu Y, Ni J
Frontiers in pharmacology 2020;11:533809
Frontiers in pharmacology 2020;11:533809
Polysaccharides of Dendrobium officinale Kimura & Migo Leaves Protect Against Ethanol-Induced Gastric Mucosal Injury via the AMPK/mTOR Signaling Pathway in Vitro and vivo.
Ke Y, Zhan L, Lu T, Zhou C, Chen X, Dong Y, Lv G, Chen S
Frontiers in pharmacology 2020;11:526349
Frontiers in pharmacology 2020;11:526349
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Zhang K, Hussain T, Wang J, Li M, Wang W, Ma X, Liao Y, Yao J, Song Y, Liang Z, Zhou X, Xu L
Frontiers in microbiology 2020;11:433
Frontiers in microbiology 2020;11:433
Photoperiod Affects Harderian Gland Morphology and Secretion in Female Cricetulus barabensis: Autophagy, Apoptosis, and Mitochondria.
Wang Z, Xu JH, Mou JJ, Kong XT, Wu M, Xue HL, Xu LX
Frontiers in physiology 2020;11:408
Frontiers in physiology 2020;11:408
α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Huang B, Liu J, Fu S, Zhang Y, Li Y, He D, Ran X, Yan X, Du J, Meng T, Gao X, Liu D
Frontiers in pharmacology 2020;11:281
Frontiers in pharmacology 2020;11:281
Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways.
Jiang H, Zeng L, Dong X, Guo S, Xing J, Li Z, Liu R
Frontiers in pharmacology 2020;11:205
Frontiers in pharmacology 2020;11:205
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Liu D, Bai X, Ma W, Xin D, Chu X, Yuan H, Qiu J, Ke H, Yin S, Chen W, Wang Z
Frontiers in pharmacology 2020;11:204
Frontiers in pharmacology 2020;11:204
The Protective Effect of Luteolin in Glucocorticoid-Induced Osteonecrosis of the Femoral Head.
Yan Z, Zhan J, Qi W, Lin J, Huang Y, Xue X, Pan X
Frontiers in pharmacology 2020;11:1195
Frontiers in pharmacology 2020;11:1195
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy.
Ye J, Lu S, Wang M, Ge W, Liu H, Qi Y, Fu J, Zhang Q, Zhang B, Sun G, Sun X
Frontiers in pharmacology 2020;11:1170
Frontiers in pharmacology 2020;11:1170
AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway.
Gao L, Liu J, Xu P, Deng G, Liu B, Yuan F, Tan Y, Sun Q, Xu Y, Zhang H, Qi Y, Han S, Yang K, Geng R, Jiang H, Chen Q
Frontiers in pharmacology 2020;11:1102
Frontiers in pharmacology 2020;11:1102
3D printed in vitro tumor tissue model of colorectal cancer.
Chen H, Cheng Y, Wang X, Wang J, Shi X, Li X, Tan W, Tan Z
Theranostics 2020;10(26):12127-12143
Theranostics 2020;10(26):12127-12143
Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.
Yang M, Liu Q, Huang T, Tan W, Qu L, Chen T, Pan H, Chen L, Liu J, Wong CW, Lu WW, Guan M
Theranostics 2020;10(24):10874-10891
Theranostics 2020;10(24):10874-10891
3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer.
Shi X, Cheng Y, Wang J, Chen H, Wang X, Li X, Tan W, Tan Z
Theranostics 2020;10(23):10652-10664
Theranostics 2020;10(23):10652-10664
Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling.
Wang L, Chai X, Wan R, Zhang H, Zhou C, Xiang L, Paul ME, Li Y
Frontiers in oncology 2020;10:595718
Frontiers in oncology 2020;10:595718
Fusobacterium nucleatum Promotes the Development of Ulcerative Colitis by Inducing the Autophagic Cell Death of Intestinal Epithelial.
Su W, Chen Y, Cao P, Chen Y, Guo Y, Wang S, Dong W
Frontiers in cellular and infection microbiology 2020;10:594806
Frontiers in cellular and infection microbiology 2020;10:594806
Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway.
Wang M, Liu C, Li Y, Zhang Q, Zhu L, Fang Z, Jin L
Frontiers in oncology 2020;10:1781
Frontiers in oncology 2020;10:1781
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Cheng L, Gou L, Wei T, Zhang J
International journal of oncology 2020 Sep;57(3):858-870
International journal of oncology 2020 Sep;57(3):858-870
Hyperbaric oxygen treatment mitigates liver damage in mice with noise exposure.
Meng X, Zhang X, Su Y, Gu Z, Xie X, Chang Y, Bao J
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1564-1574
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1564-1574
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Zhou L, Sheng W, Jia C, Shi X, Cao R, Wang G, Lin Y, Zhu F, Dong Q, Dong M
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Zhao L, Kong X, Zhong W, Wang Y, Li P
Pathology, research and practice 2020 Sep;216(9):153042
Pathology, research and practice 2020 Sep;216(9):153042
Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells.
Tian C, Zhang B, Ge C
Oncology letters 2020 Sep;20(3):2677-2688
Oncology letters 2020 Sep;20(3):2677-2688
Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.
Liu W, Zhou J, Niu F, Pu F, Wang Z, Huang M, Zhao X, Yang L, Tao P, Xia P, Feng J
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074
Bioorganic chemistry 2020 Sep;102:104074
LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.
Liu Y, Ma L, Shangguan F, Zhao X, Wang W, Gao Z, Zhou H, Qu G, Huang Y, An J, Xue J, Yang S, Cao Q
Aging 2020 Sep 5;12(16):16142-16154
Aging 2020 Sep 5;12(16):16142-16154
MiR-489 aggravates H2O2-induced apoptosis of cardiomyocytes via inhibiting IGF1.
Tang S, Zhong H, Xiong T, Yang X, Mao Y, Wang D
Bioscience reports 2020 Sep 30;40(9)
Bioscience reports 2020 Sep 30;40(9)
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Xie M, Tang Q, Yu S, Sun J, Mei F, Zhao J, Chen L
International journal of oral science 2020 Sep 30;12(1):28
International journal of oral science 2020 Sep 30;12(1):28
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Dai GH, Chen X, Ren ZM, Dai CJ, Tong YL, Chai KQ
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS
Scientific reports 2020 Sep 3;10(1):14538
Scientific reports 2020 Sep 3;10(1):14538
Protective effects of alfalfa saponins on oxidative stress-induced apoptotic cells.
Cui Y, Liu B, Sun X, Li Z, Chen Y, Guo Z, Liu H, Li D, Wang C, Zhu X, Shi Y
Food & function 2020 Sep 23;11(9):8133-8140
Food & function 2020 Sep 23;11(9):8133-8140
MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis.
Ma S, Wang Y, Zhou X, Li Z, Zhang Z, Wang Y, Huang T, Zhang Y, Shi J, Guan F
ACS chemical neuroscience 2020 Sep 2;11(17):2590-2601
ACS chemical neuroscience 2020 Sep 2;11(17):2590-2601
Inhibition of Endoplasmic Reticulum Stress-Mediated Autophagy Enhances the Anticancer Effect of Iodine-125 Seed Radiation on Esophageal Squamous Cell Carcinoma.
Wang C, Li TK, Zeng CH, Yang J, Wang Y, Lu J, Zhu GY, Guo JH
Radiation research 2020 Sep 16;194(3):236-245
Radiation research 2020 Sep 16;194(3):236-245
α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway.
Pei XD, Yao HL, Shen LQ, Yang Y, Lu L, Xiao JS, Wang XY, He ZL, Jiang LH
European journal of pharmacology 2020 Sep 15;883:173355
European journal of pharmacology 2020 Sep 15;883:173355
Maternal exposure to Di-(2-ethylhexyl) phthalate (DEHP) activates the PI3K/Akt/mTOR signaling pathway in F1 and F2 generation adult mouse testis.
Zhang J, Yao Y, Pan J, Guo X, Han X, Zhou J, Meng X
Experimental cell research 2020 Sep 15;394(2):112151
Experimental cell research 2020 Sep 15;394(2):112151
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Liu J, Deng X, Sun X, Dong J, Huang J
Life sciences 2020 Sep 15;257:118040
Life sciences 2020 Sep 15;257:118040
Effects of seawater immersion on open traumatic brain injury in rabbit model.
Liu KL, Yu XJ, Sun TZ, Wang YC, Chen MX, Su YW, Zhang HC, Chen YM, Gao HL, Shi XL, Qi J, Li Y, Li HB, Dong WJ, He JK, Kang YM
Brain research 2020 Sep 15;1743:146903
Brain research 2020 Sep 15;1743:146903
Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells.
Liu Z, Li C, Wu G, Li W, Zhang X, Zhou J, Zhang L, Tao J, Shen M, Liu H
Theriogenology 2020 Sep 15;154:120-127
Theriogenology 2020 Sep 15;154:120-127
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G
International journal of molecular sciences 2020 Sep 12;21(18)
International journal of molecular sciences 2020 Sep 12;21(18)
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Overexpression of microRNA-21-5p prevents the oxidative stress-induced apoptosis of RSC96 cells by suppressing autophagy.
Yuan M, Yang X, Duscher D, Xiong H, Ren S, Xu X, Wang C, Chen J, Liu Y, Machens HG, Chen Z
Life sciences 2020 Sep 1;256:118022
Life sciences 2020 Sep 1;256:118022
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, Shen N
Life sciences 2020 Sep 1;256:117935
Life sciences 2020 Sep 1;256:117935
CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.
Ju JQ, Li XH, Pan MH, Xu Y, Sun MH, Xu Y, Sun SC
Cell proliferation 2020 Oct;53(10):e12895
Cell proliferation 2020 Oct;53(10):e12895
Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes from Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis.
Zhang T, Liu CF, Zhang TN, Wen R, Song WL
Inflammation 2020 Oct;43(5):1806-1820
Inflammation 2020 Oct;43(5):1806-1820
Dynamin-related protein-1 promotes lung cancer A549 cells apoptosis through the F-actin/bax signaling pathway.
Liang W, Wang X, Yu X, Zuo Y, Cheng K, Yang M
Journal of receptor and signal transduction research 2020 Oct;40(5):419-425
Journal of receptor and signal transduction research 2020 Oct;40(5):419-425
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Yang ZH, Li J, Chen WZ, Kong FS
Cell biochemistry and function 2020 Oct;38(7):943-954
Cell biochemistry and function 2020 Oct;38(7):943-954
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Li Y, Zhang M, Li F
Histology and histopathology 2020 Oct;35(10):1171-1180
Histology and histopathology 2020 Oct;35(10):1171-1180
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma.
Hsu FT, Chen WT, Wu CT, Chung JG
Environmental toxicology 2020 Oct;35(10):1058-1069
Environmental toxicology 2020 Oct;35(10):1058-1069
Autophagy plays a protective role during Pseudomonas aeruginosa-induced apoptosis via ROS-MAPK pathway.
Han L, Ma Q, Yu J, Gong Z, Ma C, Xu Y, Deng G, Wu X
Innate immunity 2020 Oct;26(7):580-591
Innate immunity 2020 Oct;26(7):580-591
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
Wang B, Han D, Li F, Hou W, Wang L, Meng L, Mou K, Lu S, Zhu W, Zhou Y
Apoptosis : an international journal on programmed cell death 2020 Oct;25(9-10):663-673
Apoptosis : an international journal on programmed cell death 2020 Oct;25(9-10):663-673
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Wu X, Yu H, Zhou H, Li Z, Huang H, Xiao F, Xu S, Yang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Journal of cellular and molecular medicine 2020 Oct;24(20):11960-11971
Effect of autophagy on irradiation‑induced damage in osteoblast‑like MC3T3‑E1 cells.
Li R, Yang W, Hu X, Zhou D, Huang K, Wang C, Li Y, Liu B
Molecular medicine reports 2020 Oct;22(4):3473-3481
Molecular medicine reports 2020 Oct;22(4):3473-3481
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224
Molecular medicine reports 2020 Oct;22(4):3213-3224
Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.
Feng D, Liu M, Liu Y, Zhao X, Sun H, Zheng X, Zhu J, Shang F
Oncology letters 2020 Oct;20(4):67
Oncology letters 2020 Oct;20(4):67
Inhibitory effect of Lycium barbarum polysaccharide on sperm damage during cryopreservation.
Yan B, Zhang X, Wang J, Jia S, Zhou Y, Tian J, Wang H, Tang Y
Experimental and therapeutic medicine 2020 Oct;20(4):3051-3063
Experimental and therapeutic medicine 2020 Oct;20(4):3051-3063
Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract.
Tu Y, Xie L, Chen L, Yuan Y, Qin B, Wang K, Zhu Q, Ji N, Zhu M, Guan H
Experimental eye research 2020 Oct;199:108185
Experimental eye research 2020 Oct;199:108185
Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1.
Dahai Z, Daliang C, Famu L, Xiang W, Lenian L, Jianmin C, Xiaobing X
Brain research bulletin 2020 Oct;163:1-13
Brain research bulletin 2020 Oct;163:1-13
Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons.
Zhang S, Wang S, Shi X, Feng X
Neurochemistry international 2020 Oct;139:104815
Neurochemistry international 2020 Oct;139:104815
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, Jin X, Jiang L, Lou Y, Qiu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.
Shao Z, Pan Z, Lin J, Zhao Q, Wang Y, Ni L, Feng S, Tian N, Wu Y, Sun L, Gao W, Zhou Y, Zhang X, Wang X
Aging 2020 Oct 7;12(19):19254-19272
Aging 2020 Oct 7;12(19):19254-19272
Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice.
Zhang X, Gou YJ, Zhang Y, Li J, Han K, Xu Y, Li H, You LH, Yu P, Chang YZ, Gao G
Cell death discovery 2020 Oct 30;6(1):113
Cell death discovery 2020 Oct 30;6(1):113
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Yao Q, Zhou Y, Yang Y, Cai L, Xu L, Han X, Guo Y, Li PA
Journal of ethnopharmacology 2020 Oct 28;261:113165
Journal of ethnopharmacology 2020 Oct 28;261:113165
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Lv R, Du L, Zhou F, Yuan X, Liu X, Zhang L
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Deng H, Yu B, Yu Y, Tian G, Yang L
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Hepatoprotective effects of Di Wu Yang Gan: A medicinal food against CCl(4)-induced hepatotoxicity in vivo and in vitro.
Xu W, Xiao M, Li J, Chen Y, Sun Q, Li H, Sun W
Food chemistry 2020 Oct 15;327:127093
Food chemistry 2020 Oct 15;327:127093
Titanium Dioxide Nanoparticles Induced HeLa Cell Necrosis under UVA Radiation through the ROS-mPTP Pathway.
Geng R, Ren Y, Rao R, Tan X, Zhou H, Yang X, Liu W, Lu Q
Nanomaterials (Basel, Switzerland) 2020 Oct 15;10(10)
Nanomaterials (Basel, Switzerland) 2020 Oct 15;10(10)
The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat.
Fu G, Dai J, Li Z, Chen F, Liu L, Yi L, Teng Z, Quan C, Zhang L, Zhou T, Donkersley P, Song S, Shi Y
Toxicology and applied pharmacology 2020 Oct 1;404:115151
Toxicology and applied pharmacology 2020 Oct 1;404:115151
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Chen Y, Niu J, Li L, Li Z, Jiang J, Zhu M, Dong T, Zhang J, Shi C, Xu P, Lu Y, Jiang Y, Liu P, Chen W
Life sciences 2020 Oct 1;258:118158
Life sciences 2020 Oct 1;258:118158
EZH2 expression and its role in spermatogonial stem cell self-renewal in goats.
Cai Y, Deng M, Liu Z, Zhang G, Pang J, An S, Wang Z, Zhang Y, Wang F
Theriogenology 2020 Oct 1;155:222-231
Theriogenology 2020 Oct 1;155:222-231
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Zhang H, Lang W, Wang S, Li B, Li G, Shi Q
International immunopharmacology 2020 Nov;88:106974
International immunopharmacology 2020 Nov;88:106974
Knockdown of fatty acid binding protein 4 exacerbates Bacillus Calmette-Guerin infection-induced RAW264.7 cell apoptosis via the endoplasmic reticulum stress pathway.
Yu J, Ma C, Xu Y, Han L, Wu X, Wang Y, Deng G
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2020 Nov;85:104552
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2020 Nov;85:104552
CaMKII as a key regulator of contrast-induced nephropathy through mPTP opening in HK-2 cells.
Hu C, Zhou G, Liu K, Yin W, Zhou L, Wang J, Chen L, Zuo S, Xie Y, Zuo X
Cellular signalling 2020 Nov;75:109734
Cellular signalling 2020 Nov;75:109734
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Tan X, Li T, Zhu S, Zhong W, Li F, Wang Y
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression.
Guo XD, Zhang N, Sha L
Neoplasma 2020 Nov;67(6):1293-1302
Neoplasma 2020 Nov;67(6):1293-1302
LGR5 constitutively activates NF-κB signaling to regulate the growth of intestinal crypts.
Lai S, Cheng R, Gao D, Chen YG, Deng C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15605-15620
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15605-15620
miR-130a promotes immature porcine Sertoli cell growth by activating SMAD5 through the TGF-β-PI3K/AKT signaling pathway.
Luo H, Chen B, Weng B, Tang X, Chen Y, Yang A, Chu D, Zeng X, Ran M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15164-15179
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15164-15179
Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC.
Li XY, Wang DP, Lu GQ, Liu KL, Zhang TJ, Li S, Mohamed O K, Xue WH, Qian XH, Meng FH
Journal of advanced research 2020 Nov;26:95-110
Journal of advanced research 2020 Nov;26:95-110
Novel ultrastructural findings on cardiac mitochondria of huddling Brandt's voles in mild cold environment.
Wang Z, Xu JH, Mou JJ, Kong XT, Zou JW, Xue HL, Wu M, Xu LX
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2020 Nov;249:110766
Eva-1 homolog A promotes papillary thyroid cancer progression and epithelial-mesenchymal transition via the Hippo signalling pathway.
Lin BY, Wen JL, Zheng C, Lin LZ, Chen CZ, Qu JM
Journal of cellular and molecular medicine 2020 Nov;24(22):13070-13080
Journal of cellular and molecular medicine 2020 Nov;24(22):13070-13080
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury.
Zhang X, Jing Y, Qin C, Liu C, Yang D, Gao F, Yang M, Du L, Li J
Journal of cellular and molecular medicine 2020 Nov;24(21):12765-12776
Journal of cellular and molecular medicine 2020 Nov;24(21):12765-12776
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Zhai J, Li Z, Zhang H, Ma L, Ma Z, Zhang Y, Zou J, Li M, Ma L, Wang X, Li X
Molecular medicine reports 2020 Nov;22(5):4227-4235
Molecular medicine reports 2020 Nov;22(5):4227-4235
miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.
Zhu L, Zhou X, Li S, Liu J, Yang J, Fan X, Zhou S
Molecular medicine reports 2020 Nov;22(5):3944-3954
Molecular medicine reports 2020 Nov;22(5):3944-3954
MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma.
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Sun L, Sun C, Feng W, Guo SB
Molecular medicine reports 2020 Nov;22(5):3911-3921
Molecular medicine reports 2020 Nov;22(5):3911-3921
Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.
Wei J, Yu W, Hao R, Fan J, Gao J
Chemistry & biodiversity 2020 Nov;17(11):e2000654
Chemistry & biodiversity 2020 Nov;17(11):e2000654
Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Zhong Y, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111740
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111740
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Ji Y, Yao J, He Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Li T, Zhang L, Jin C, Xiong Y, Cheng YY, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Liang Y, Zheng B, Li J, Shi J, Chu L, Han X, Chu X, Zhang X, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110713
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110713
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Liang Z, Zhong Y, Meng L, Chen Y, Liu Y, Wu A, Li X, Wang M
Thoracic cancer 2020 Nov;11(11):3155-3167
Thoracic cancer 2020 Nov;11(11):3155-3167
Mycoplasma bovis-generated reactive oxygen species and induced apoptosis in bovine mammary epithelial cell cultures.
Liu Y, Zhou M, Xu S, Khan MA, Shi Y, Qu W, Gao J, Liu G, Kastelic JP, Han B
Journal of dairy science 2020 Nov;103(11):10429-10445
Journal of dairy science 2020 Nov;103(11):10429-10445
Gastrodin alleviates bone damage by modulating protein expression and tissue redox state.
Zheng B, Shi C, Muhammed FK, He J, Abdullah AO, Liu Y
FEBS open bio 2020 Nov;10(11):2404-2416
FEBS open bio 2020 Nov;10(11):2404-2416
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Shen Y, Zou Y, Li J, Chen F, Li H, Cai Y
International journal of molecular sciences 2020 Nov 9;21(21)
International journal of molecular sciences 2020 Nov 9;21(21)
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Kong Z, Zhou C, Kang J, Tan Z
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
[IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy].
Wang L, Zhang X, Wang L, Wang B, Zhang J, Li Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020 Nov 30;40(11):1550-1556
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020 Nov 30;40(11):1550-1556
USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
Wang SA, Young MJ, Jeng WY, Liu CY, Hung JJ
Scientific reports 2020 Nov 30;10(1):20870
Scientific reports 2020 Nov 30;10(1):20870
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
Yuan J, Zhang G, Li X, Ma Q, Cheng W, Wang W, Zhang B, Hu T, Song G
International journal of molecular sciences 2020 Nov 25;21(23)
International journal of molecular sciences 2020 Nov 25;21(23)
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway.
Chen X, Ren L, Liu X, Sun X, Dong C, Jiang Y, Qin Y, Qu H, Jiao J, Wang S, Bai Y, Yang B
Life sciences 2020 Nov 15;261:118306
Life sciences 2020 Nov 15;261:118306
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Wu J, Wu Y, Lian X
Biology open 2020 Nov 12;9(11)
Biology open 2020 Nov 12;9(11)
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Sun X, Liu H, Sun Z, Zhang B, Wang X, Liu T, Pan T, Gao Y, Jiang X, Li H
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Xin X, Li Y, Liu H
Scientific reports 2020 Nov 10;10(1):19426
Scientific reports 2020 Nov 10;10(1):19426
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X
Life sciences 2020 Nov 1;260:118413
Life sciences 2020 Nov 1;260:118413
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Wang L, Tan Z, Zhang Y, Kady Keita N, Liu H, Zhang Y
International journal of oncology 2020 May;56(5):1162-1174
International journal of oncology 2020 May;56(5):1162-1174
miR-362 knock-down promotes proliferation and inhibits apoptosis in porcine immature Sertoli cells by targeting the RMI1 gene.
Ran M, Luo H, Gao H, Tang X, Chen Y, Zeng X, Weng B, Chen B
Reproduction in domestic animals = Zuchthygiene 2020 May;55(5):547-558
Reproduction in domestic animals = Zuchthygiene 2020 May;55(5):547-558
Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.
Chang L, Shi R, Wang X, Bao Y
BioFactors (Oxford, England) 2020 May;46(3):432-440
BioFactors (Oxford, England) 2020 May;46(3):432-440
Metformin suppresses proliferation and invasion of drug-resistant breast cancer cells by activation of the Hippo pathway.
Liu J, Li J, Chen H, Wang R, Li P, Miao Y, Liu P
Journal of cellular and molecular medicine 2020 May;24(10):5786-5796
Journal of cellular and molecular medicine 2020 May;24(10):5786-5796
LINC00963 targeting miR-128-3p promotes acute kidney injury process by activating JAK2/STAT1 pathway.
Xie LB, Chen B, Liao X, Chen YF, Yang R, He SR, Pei LJ, Jiang R
Journal of cellular and molecular medicine 2020 May;24(10):5555-5564
Journal of cellular and molecular medicine 2020 May;24(10):5555-5564
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
Li S, Zhai J, Chu W, Geng X, Chen ZJ, Du Y
Translational research : the journal of laboratory and clinical medicine 2020 May;219:13-29
Translational research : the journal of laboratory and clinical medicine 2020 May;219:13-29
The Association Between Thyroid Injury and Apoptosis, and Alterations of Bax, Bcl-2, and Caspase-3 mRNA/Protein Expression Induced by Nickel Sulfate in Wistar Rats.
Liu Y, Chen H, Zhang L, Zhang T, Ren X
Biological trace element research 2020 May;195(1):159-168
Biological trace element research 2020 May;195(1):159-168
Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters.
Huo X, Meng Q, Wang C, Wu J, Wang C, Zhu Y, Ma X, Sun H, Liu K
British journal of pharmacology 2020 May;177(9):1933-1948
British journal of pharmacology 2020 May;177(9):1933-1948
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer.
Zhang X, Wang Y, Liu X, Zhao A, Yang Z, Kong F, Sun L, Yu Y, Jiang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109840
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109840
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Xu F, Ye ML, Zhang YP, Li WJ, Li MT, Wang HZ, Qiu X, Xu Y, Yin JW, Hu Q, Wei WH, Chang Y, Liu L, Zhao Q
Cancer science 2020 May;111(5):1528-1541
Cancer science 2020 May;111(5):1528-1541
Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
Zhang XM, Wang YZ, Tong JD, Ning XC, Zhou FQ, Yang XH, Jin HM
FEBS open bio 2020 May;10(5):827-834
FEBS open bio 2020 May;10(5):827-834
Lactoferrin Contributes a Renoprotective Effect in Acute Kidney Injury and Early Renal Fibrosis.
Hsu YH, Chiu IJ, Lin YF, Chen YJ, Lee YH, Chiu HW
Pharmaceutics 2020 May 8;12(5)
Pharmaceutics 2020 May 8;12(5)
Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4(+) T cell apoptosis.
An K, Xue MJ, Zhong JY, Yu SN, Lan TS, Qi ZQ, Xia JJ
Journal of neuroinflammation 2020 May 6;17(1):147
Journal of neuroinflammation 2020 May 6;17(1):147
Oct4 plays a role in 2, 3, 7, 8 - tetrachlorobenzo-p-dioxin (TCDD) inducing cleft palate and inhibiting mesenchymal proliferation.
Tao Y, Liu X, Cui L, Liu X, Chen Y, He Z, Ji M, Gao Z, Li N, Wan Z, Yu Z
Toxicology 2020 May 30;438:152444
Toxicology 2020 May 30;438:152444
Pinocembrin mitigates depressive-like behaviors induced by chronic unpredictable mild stress through ameliorating neuroinflammation and apoptosis.
Wang W, Zheng L, Xu L, Tu J, Gu X
Molecular medicine (Cambridge, Mass.) 2020 May 27;26(1):53
Molecular medicine (Cambridge, Mass.) 2020 May 27;26(1):53
circStrn3 is involved in bone cancer pain regulation in a rat model.
Zhang Y, Zhang X, Xing Z, Tang S, Chen H, Zhang Z, Li J, Li Y
Acta biochimica et biophysica Sinica 2020 May 26;52(5):495-505
Acta biochimica et biophysica Sinica 2020 May 26;52(5):495-505
MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.
Du J, Li J, Gao M, Guan Q, Liu T, Wu Y, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2020 May 25;323:109074
Chemico-biological interactions 2020 May 25;323:109074
Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms.
Wang R, Wang S, Chan S, Wang Y, Zhang Y, Zuo Z, Chi-Fung Chan G, Li H, Sun H
iScience 2020 May 22;23(5):101054
iScience 2020 May 22;23(5):101054
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2.
Yang Y, Liu S, Gao H, Wang P, Zhang Y, Zhang A, Jia Z, Huang S
Free radical biology & medicine 2020 May 20;152:821-837
Free radical biology & medicine 2020 May 20;152:821-837
Butyrate alleviates oxidative stress by regulating NRF2 nuclear accumulation and H3K9/14 acetylation via GPR109A in bovine mammary epithelial cells and mammary glands.
Guo W, Liu J, Sun J, Gong Q, Ma H, Kan X, Cao Y, Wang J, Fu S
Free radical biology & medicine 2020 May 20;152:728-742
Free radical biology & medicine 2020 May 20;152:728-742
MS-275 combined with cisplatin exerts synergistic antitumor effects in human esophageal squamous cell carcinoma cells.
Liu T, Guan F, Wang Y, Zhang Z, Li Y, Cui Y, Li Z, Liu H, Zhang Y, Wang Y, Ma S
Toxicology and applied pharmacology 2020 May 15;395:114971
Toxicology and applied pharmacology 2020 May 15;395:114971
Hsp90 inhibition aggravates adriamycin-induced podocyte injury through intrinsic apoptosis pathway.
Dong J, Jiang Z, Ma G
Experimental cell research 2020 May 15;390(2):111928
Experimental cell research 2020 May 15;390(2):111928
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
Li T, Wu S, Jia L, Cao W, Yao Y, Zhao G, Li H
Cancer biology & medicine 2020 May 15;17(2):357-370
Cancer biology & medicine 2020 May 15;17(2):357-370
Stimuli-Responsive Polysaccharide Enveloped Liposome for Targeting and Penetrating Delivery of survivin-shRNA into Breast Tumor.
Chen H, Fan X, Zhao Y, Zhi D, Cui S, Zhang E, Lan H, Du J, Zhang Z, Zhang S, Zhen Y
ACS applied materials & interfaces 2020 May 13;12(19):22074-22087
ACS applied materials & interfaces 2020 May 13;12(19):22074-22087
Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke.
Zhang KY, Rui G, Zhang JP, Guo L, An GZ, Lin JJ, He W, Ding GR
BMC neuroscience 2020 May 12;21(1):21
BMC neuroscience 2020 May 12;21(1):21
Camellia oil (Camellia oleifera Abel.) attenuates CCl(4)-induced liver fibrosis via suppressing hepatocyte apoptosis in mice.
Lei X, Liu Q, Liu Q, Cao Z, Zhang J, Kuang T, Fang Y, Liu G, Qian K, Fu J, Du H, Liu Z, Xiao Z, Li C, Xu X
Food & function 2020 May 1;11(5):4582-4590
Food & function 2020 May 1;11(5):4582-4590
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Jiang L, He C, Zhang X, Chen Y, Li G
Translational cancer research 2020 Mar;9(3):1851-1860
Translational cancer research 2020 Mar;9(3):1851-1860
LncRNA FAM66C inhibits pancreatic cancer progression by sponging miR-574-3p.
Zhu J, Zhu S, Yu Q, Wu Y
Translational cancer research 2020 Mar;9(3):1806-1817
Translational cancer research 2020 Mar;9(3):1806-1817
Danshen formula granule and salvianic acid A alleviate ethanol-induced neurotoxicity.
Li Y, Chen H, Yang Y, Niu M, Wang J, Wu Y, Niu L, Liu H, Bao D
Journal of natural medicines 2020 Mar;74(2):399-408
Journal of natural medicines 2020 Mar;74(2):399-408
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Ma Z, Yang J, Yang Y, Wang X, Chen G, Shi A, Lu Y, Jia S, Kang X, Lu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Mar;68:153186
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Mar;68:153186
Silencing of TPD52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating Akt pathway.
Wang Z, Li Y, Fan L, Zhao Q, Tan B, Liu R, Li F
Neoplasma 2020 Mar;67(2):277-285
Neoplasma 2020 Mar;67(2):277-285
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Wang X, Liu M, Zhu MJ, Shi L, Liu L, Zhao YL, Cheng L, Gu YJ, Zhou MY, Chen L, Kumar A, Wang Y
Cell proliferation 2020 Mar;53(3):e12773
Cell proliferation 2020 Mar;53(3):e12773
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Gucer H, Caliskan S, Kefeli M, Mete O
Endocrine pathology 2020 Mar;31(1):33-38
Endocrine pathology 2020 Mar;31(1):33-38
Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract.
Chen L, Wu X, Zeb F, Huang Y, An J, Jiang P, Chen A, Xu C, Feng Q
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113735
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113735
Liver-derived exosome-laden lncRNA MT1DP aggravates cadmium-induced nephrotoxicity.
Gao M, Dong Z, Sun J, Liu W, Xu M, Li C, Zhu P, Yang X, Shang X, Wu Y, Liu S
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113717
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113717
C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium.
Song W, Sheng L, Chen F, Tian Y, Li L, Wang G, Li H, Cai Y
Cell stress & chaperones 2020 Mar;25(2):223-233
Cell stress & chaperones 2020 Mar;25(2):223-233
Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression.
Li HR, Wang C, Sun P, Liu DD, Du GQ, Tian JW
Journal of cellular and molecular medicine 2020 Mar;24(6):3634-3646
Journal of cellular and molecular medicine 2020 Mar;24(6):3634-3646
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.
Liu L, Liu Y, Li N, Huang R, Zheng X, Huang L, Hou S, Yuan Q
Brain research bulletin 2020 Mar;156:86-104
Brain research bulletin 2020 Mar;156:86-104
CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma.
Di M, Wang M, Miao J, Chen B, Huang H, Lin C, Jian Y, Li Y, Ouyang Y, Chen X, Wang L, Zhao C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109748
The mechanism of PDA/PEI/5-Fu coated esophageal stent material on inhibiting cancer associated pathological cells.
Zhang K, Bai Y, Xu R, Li J, Guan F
Journal of biomedical materials research. Part A 2020 Mar;108(3):814-821
Journal of biomedical materials research. Part A 2020 Mar;108(3):814-821
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Zhang X, Wang Z, Li W, Huang R, Zheng D, Bi G
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
Long non-coding RNA HAL suppresses the migration and invasion of serous ovarian cancer by inhibiting EMT signaling pathway.
Wu K, Li L, Li L, Wang D
Bioscience reports 2020 Mar 27;40(3)
Bioscience reports 2020 Mar 27;40(3)
Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats.
Zhang X, Zhang X, Li X, Ma J, Xie D, Jiang N
Neuroscience letters 2020 Mar 23;722:134862
Neuroscience letters 2020 Mar 23;722:134862
Alarmin HMGB1 Plays a Detrimental Role in Hippocampal Dysfunction Caused by Hypoxia-Ischemia Insult in Neonatal Mice: Evidence from the Application of the HMGB1 Inhibitor Glycyrrhizin.
Le K, Wu S, Chibaatar E, Ali AI, Guo Y
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
ACS chemical neuroscience 2020 Mar 18;11(6):979-993
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862
Experimental cell research 2020 Mar 15;388(2):111862
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, Yu M, Zhang Y, Li X, Ye X
Life sciences 2020 Mar 15;245:117387
Life sciences 2020 Mar 15;245:117387
PHLDA1 is a new therapeutic target of oxidative stress and ischemia reperfusion-induced myocardial injury.
Guo Y, Jia P, Chen Y, Yu H, Xin X, Bao Y, Yang H, Wu N, Sun Y, Jia D
Life sciences 2020 Mar 15;245:117347
Life sciences 2020 Mar 15;245:117347
LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p/IGF-1 axis in human granulosa-like tumor cell line KGN.
Chen Y, Zhang X, An Y, Liu B, Lu M
Molecular and cellular endocrinology 2020 Mar 1;503:110697
Molecular and cellular endocrinology 2020 Mar 1;503:110697
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Li Q, Tong D, Guo C, Wu F, Li F, Wang X, Jiang Q, Wei Y, Liu L, Ni L, Guo B, Huang C
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
Annexin A7 induction of neuronal apoptosis via effect on glutamate release in a rat model of subarachnoid hemorrhage.
Lin QS, Wang WX, Lin YX, Lin ZY, Yu LH, Kang Y, Kang DZ
Journal of neurosurgery 2020 Mar 1;132(3):777-787
Journal of neurosurgery 2020 Mar 1;132(3):777-787
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, Wang T, Chen Z, Fan Y, Liang D, Meng Q
Molecular carcinogenesis 2020 Jun;59(6):575-589
Molecular carcinogenesis 2020 Jun;59(6):575-589
Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.
Peng F, Li G, Xie Y, Yin HY, Li XJ, Yang YD
Journal of food biochemistry 2020 Jun;44(6):e13222
Journal of food biochemistry 2020 Jun;44(6):e13222
Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.
Wang W, Huang L, Hu Y, Thomas ER, Li X
Human & experimental toxicology 2020 Jun;39(6):797-807
Human & experimental toxicology 2020 Jun;39(6):797-807
Neuroprotective effects of miR-532-5p against ischemic stroke.
Mu J, Cheng X, Zhong S, Chen X, Zhao C
Metabolic brain disease 2020 Jun;35(5):753-763
Metabolic brain disease 2020 Jun;35(5):753-763
Anti-human serum albumin autoantibody may be involved in the pathogenesis of autoimmune bullous skin diseases.
Qian H, Cao Y, Sun J, Zu J, Ma L, Zhou H, Tang X, Li Y, Yu H, Zhang M, Bai Y, Xu C, Ishii N, Hashimoto T, Li X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8574-8595
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8574-8595
Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke.
Liu X, Hu R, Pei L, Si P, Wang C, Tian X, Wang X, Liu H, Wang B, Xia Z, Xu Y, Song B
Experimental neurology 2020 Jun;328:113233
Experimental neurology 2020 Jun;328:113233
miR-22 represses osteoblast viability with ESR1 presenting a direct target and indirectly inactivating p38 MAPK/JNK signaling.
Chen GH, Zhang XL, Chen H, Lin H, Wu HJ, Lin H, Huang GZ
The journal of gene medicine 2020 Jun;22(6):e3174
The journal of gene medicine 2020 Jun;22(6):e3174
Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway.
Qi Y, Qian R, Jia L, Fei X, Zhang D, Zhang Y, Jiang S, Fu X
Cell cycle (Georgetown, Tex.) 2020 Jun;19(11):1298-1313
Cell cycle (Georgetown, Tex.) 2020 Jun;19(11):1298-1313
Sodium tanshinone IIA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts.
Zhou D, Yang WK, Zhang YF, Xie JH, Ma L, Yang HD, Li Y, Xie P
Chinese journal of natural medicines 2020 Jun;18(6):436-445
Chinese journal of natural medicines 2020 Jun;18(6):436-445
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Wu J, He J, Tian X, Luo Y, Zhong J, Zhang H, Li H, Cen B, Jiang T, Sun X
Journal of neurochemistry 2020 Jun;153(6):710-726
Journal of neurochemistry 2020 Jun;153(6):710-726
lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.
Su X, Lv L, Li Y, Fang R, Yang R, Li C, Li T, Zhu D, Li X, Zhou Y, Shan H, Liang H
Molecular therapy. Nucleic acids 2020 Jun 5;20:841-850
Molecular therapy. Nucleic acids 2020 Jun 5;20:841-850
Quantitative iTRAQ LC-MS/MS reveals muscular proteome profiles of deep pressure ulcers.
Liu Z, Cui X, Hu Y, Zhang P
Bioscience reports 2020 Jun 26;40(6)
Bioscience reports 2020 Jun 26;40(6)
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2.
Mamriev D, Abbas R, Klingler FM, Kagan J, Kfir N, Donald A, Weidenfeld K, Sheppard DW, Barkan D, Larisch S
Cell death & disease 2020 Jun 25;11(6):483
Cell death & disease 2020 Jun 25;11(6):483
IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH.
He Y, Gao Y, Zhang Q, Zhou G, Cao F, Yao S
Neuroscience 2020 Jun 15;437:161-171
Neuroscience 2020 Jun 15;437:161-171
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
Liu H, Zhang W, Fang Y, Yang H, Tian L, Li K, Lai W, Bian L, Lin B, Liu X, Xi Z
Journal of hazardous materials 2020 Jun 15;392:122312
Journal of hazardous materials 2020 Jun 15;392:122312
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.
Cao YY, Ba HX, Li Y, Tang SY, Luo ZQ, Li XH
Life sciences 2020 Jun 1;250:117548
Life sciences 2020 Jun 1;250:117548
Crocin protects against cardiotoxicity induced by doxorubicin through TLR-2/NF-κB signal pathway in vivo and vitro.
Chu X, Zhang Y, Xue Y, Li Z, Shi J, Wang H, Chu L
International immunopharmacology 2020 Jul;84:106548
International immunopharmacology 2020 Jul;84:106548
Long Noncoding RNA LNC_000898 Alleviates Cardiomyocyte Apoptosis and Promotes Cardiac Repair After Myocardial Infarction Through Modulating the miR-375/PDK1 Axis.
Yan M, Liu Q, Jiang Y, Wang B, Ji Y, Liu H, Xie Y
Journal of cardiovascular pharmacology 2020 Jul;76(1):77-85
Journal of cardiovascular pharmacology 2020 Jul;76(1):77-85
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196
International journal of oncology 2020 Jul;57(1):183-196
4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice.
Cao Y, Liu Z, Xiao W, Gu Z, Xiao G, Yuan F, Chen F, Pei Y, Li H, Su L
Shock (Augusta, Ga.) 2020 Jul;54(1):102-109
Shock (Augusta, Ga.) 2020 Jul;54(1):102-109
The roles of SHANK1 in the development of colon cancer.
Wang L, Lv Y, Liu G
Cell biochemistry and function 2020 Jul;38(5):669-675
Cell biochemistry and function 2020 Jul;38(5):669-675
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
Zhu L, Dai L, Yang N, Liu M, Ma S, Li C, Shen J, Lin T, Wang D, Pan W, Li X
Cell biochemistry and function 2020 Jul;38(5):621-629
Cell biochemistry and function 2020 Jul;38(5):621-629
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
Hu C, Xia H, Bai S, Zhao J, Edwards H, Li X, Yang Y, Lyu J, Wang G, Zhan Y, Dong Y, Ge Y
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
A novel antitumor dithiocarbamate compound inhibits the EGFR/AKT signaling pathway and induces apoptosis in esophageal cancer cells.
Yang Y, Tian Z, Zhao X, Li Y, Duan S
Oncology letters 2020 Jul;20(1):877-883
Oncology letters 2020 Jul;20(1):877-883
lncRNA KCNQ1OT1 knockdown inhibits colorectal cancer cell proliferation, migration and invasiveness via the PI3K/AKT pathway.
Duan Q, Cai L, Zheng K, Cui C, Huang R, Zheng Z, Xie L, Wu C, Yu X, Yu J
Oncology letters 2020 Jul;20(1):601-610
Oncology letters 2020 Jul;20(1):601-610
Vitamin D3 mediates miR-15a-5p inhibition of liver cancer cell proliferation via targeting E2F3.
Li Y, Lin Q, Chang S, Zhang R, Wang J
Oncology letters 2020 Jul;20(1):292-298
Oncology letters 2020 Jul;20(1):292-298
ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.
Gou W, Li Z, Xu X, Shen J, Guo M, Zhou X, Zhang X, Wu Y, Zhai X, Zuo D
Biochimica et biophysica acta. Molecular cell research 2020 Jul;1867(7):118712
Biochimica et biophysica acta. Molecular cell research 2020 Jul;1867(7):118712
Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway.
Du L, Mei Z, Huang Y, Tao W, Wang K, Huang W, Zhou H, Feng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110123
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jul;127:110123
Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis.
Qian YC, Xie YX, Wang CS, Shi ZM, Jiang CF, Tang YY, Qian X, Wang L, Jiang BH
Asian journal of andrology 2020 Jul-Aug;22(4):414-421
Asian journal of andrology 2020 Jul-Aug;22(4):414-421
PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.
Yu W, Hua Y, Qiu H, Hao J, Zou K, Li Z, Hu S, Guo P, Chen M, Sui S, Xiong Y, Li F, Lu J, Guo W, Luo G, Deng W
Cell death & disease 2020 Jul 6;11(7):506
Cell death & disease 2020 Jul 6;11(7):506
LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma.
Zheng S, Wan L, Ge D, Jiang F, Qian Z, Tang J, Yang J, Yao Y, Yan J, Zhao L, Li H, Yang L
Cell death & disease 2020 Jul 24;11(7):576
Cell death & disease 2020 Jul 24;11(7):576
(Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.
Gao X, Zhang S, Wang D, Cheng Y, Jiang Y, Liu Y
Physiological research 2020 Jul 16;69(3):427-438
Physiological research 2020 Jul 16;69(3):427-438
Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p.
Tian D, Xiang Y, Tang Y, Ge Z, Li Q, Zhang Y
Cell death & disease 2020 Jul 13;11(7):526
Cell death & disease 2020 Jul 13;11(7):526
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Li S, Li XY, Zhang TJ, Kamara MO, Liang JW, Zhu J, Meng FH
Bioorganic chemistry 2020 Jan;94:103385
Bioorganic chemistry 2020 Jan;94:103385
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1.
Lin D, Cui B, Ma J, Ren J
BioFactors (Oxford, England) 2020 Jan;46(1):83-93
BioFactors (Oxford, England) 2020 Jan;46(1):83-93
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Jin W, Zhang Y, Xue Y, Han X, Zhang X, Ma Z, Sun S, Chu X, Cheng J, Guan S, Li Z, Chu L
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
Naunyn-Schmiedeberg's archives of pharmacology 2020 Jan;393(1):13-23
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Yang QY, Yang KP, Li ZZ
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The pro-inflammatory effect of NR4A3 in osteoarthritis.
Ma C, Wu L, Song L, He Y, Adel Abdo Moqbel S, Yan S, Sheng K, Wu H, Ran J, Wu L
Journal of cellular and molecular medicine 2020 Jan;24(1):930-940
Journal of cellular and molecular medicine 2020 Jan;24(1):930-940
LncRNA ACART protects cardiomyocytes from apoptosis by activating PPAR-γ/Bcl-2 pathway.
Wu H, Zhu H, Zhuang Y, Zhang J, Ding X, Zhan L, Luo S, Zhang Q, Sun F, Zhang M, Pan Z, Lu Y
Journal of cellular and molecular medicine 2020 Jan;24(1):737-746
Journal of cellular and molecular medicine 2020 Jan;24(1):737-746
TRB3 interacts with ERK and JNK and contributes to the proliferation, apoptosis, and migration of lung adenocarcinoma cells.
Cao X, Fang X, Malik WS, He Y, Li X, Xie M, Sun W, Xu Y, Liu X
Journal of cellular physiology 2020 Jan;235(1):538-547
Journal of cellular physiology 2020 Jan;235(1):538-547
LINC00365-SCGB2A1 axis inhibits the viability of breast cancer through targeting NF-κB signaling.
Zhang L, Yan X, Yu S, Zhong X, Tian R, Xu L, Bian X, Su J
Oncology letters 2020 Jan;19(1):753-762
Oncology letters 2020 Jan;19(1):753-762
Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells.
Zhao X, Su L, He X, Zhao B, Miao J
Autophagy 2020 Jan;16(1):70-85
Autophagy 2020 Jan;16(1):70-85
Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.
Zheng Y, Nie P, Xu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628
Enhanced UV Resistance Role of Death Domain-Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint.
Shan Z, Liu L, Shen J, Hao H, Zhang H, Lei L, Liu F, Wang Z
Cell transplantation 2020 Jan-Dec;29:963689720920277
Cell transplantation 2020 Jan-Dec;29:963689720920277
The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.
Huang A, Chen L, Wang Y, Ma S, Jin S, Cai H, Huang X, Zhang H, Wang Z, Lin K, Lin F
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820964215
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820964215
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, Yuan X, Sha Q
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Zhu Y, Shi F, Wang M, Ding J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter.
Jiang W, Yan Y, Chen M, Luo G, Hao J, Pan J, Hu S, Guo P, Li W, Wang R, Zuo Y, Sun Y, Sui S, Yu W, Pan Z, Zou K, Zheng Z, Deng W, Wu X, Guo W
Aging 2020 Jan 6;12(1):611-627
Aging 2020 Jan 6;12(1):611-627
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer.
Hu M, Yu Z, Mei P, Li J, Luo D, Zhang H, Zhou M, Liang F, Chen R
Aging 2020 Jan 3;12(1):138-155
Aging 2020 Jan 3;12(1):138-155
Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p.
Cheng Y, Li J, Wang C, Yang H, Wang Y, Zhan T, Guo S, Liang J, Bai Y, Yu J, Liu G
Experimental animals 2020 Jan 29;69(1):34-44
Experimental animals 2020 Jan 29;69(1):34-44
Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine.
Zhang W, Gao J, Cheng C, Zhang M, Liu W, Ma X, Lei W, Hao E, Hou X, Hou Y, Bai G
Cancers 2020 Jan 29;12(2)
Cancers 2020 Jan 29;12(2)
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.
Hu M, Yang J, Qu L, Deng X, Duan Z, Fu R, Liang L, Fan D
Food & function 2020 Jan 29;11(1):456-471
Food & function 2020 Jan 29;11(1):456-471
Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells.
Xiong Y, Yin Q, Jin E, Chen H, He S
Molecules (Basel, Switzerland) 2020 Jan 28;25(3)
Molecules (Basel, Switzerland) 2020 Jan 28;25(3)
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Liu Y, Fan D
Nutrients 2020 Jan 18;12(1)
Nutrients 2020 Jan 18;12(1)
Propofol facilitates migration and invasion of oral squamous cell carcinoma cells by upregulating SNAI1 expression.
Li C, Xia M, Wang H, Li W, Peng J, Jiang H
Life sciences 2020 Jan 15;241:117143
Life sciences 2020 Jan 15;241:117143
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M, Huang C
Life sciences 2020 Jan 15;241:117115
Life sciences 2020 Jan 15;241:117115
Novel diosgenin derivatives containing 1,3,4-oxadiazole/thiadiazole moieties as potential antitumor agents: Design, synthesis and cytotoxic evaluation.
Zhang J, Wang X, Yang J, Guo L, Wang X, Song B, Dong W, Wang W
European journal of medicinal chemistry 2020 Jan 15;186:111897
European journal of medicinal chemistry 2020 Jan 15;186:111897
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Hua W, Li S, Luo R, Wu X, Zhang Y, Liao Z, Song Y, Wang K, Zhao K, Yang S, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.
Wang Y, Liang HX, Zhang CM, Zou M, Zou BB, Wei W, Hu W
Translational cancer research 2020 Feb;9(2):937-948
Translational cancer research 2020 Feb;9(2):937-948
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Liang LY, Wang MM, Liu M, Zhao W, Wang X, Shi L, Zhu MJ, Zhao YL, Liu L, Maurya P, Wang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Chen M, Zhu LL, Su JL, Li GL, Wang J, Zhang YN
Human & experimental toxicology 2020 Feb;39(2):173-181
Human & experimental toxicology 2020 Feb;39(2):173-181
A randomized phase 2 trial of apatinib vs observation as maintenance treatment following first-line induction chemotherapy in extensive- stage small cell lung cancer.
Luo H, Zhang L, Yang B, Feng Y, Xiong Y, Zhang S, Li X, Qian C, Dong W, Dai N
Investigational new drugs 2020 Feb;38(1):148-159
Investigational new drugs 2020 Feb;38(1):148-159
Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78.
Gong C, Hu X, Xu Y, Yang J, Zong L, Wang C, Zhu J, Li Z, Lu D
Anti-cancer drugs 2020 Feb;31(2):141-149
Anti-cancer drugs 2020 Feb;31(2):141-149
FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.
Chen R, Li D, Zheng M, Chen B, Wei T, Wang Y, Li M, Huang W, Tong Q, Wang Q, Zhu Y, Fang W, Guo L, Fang S
Journal of cellular and molecular medicine 2020 Feb;24(3):2123-2134
Journal of cellular and molecular medicine 2020 Feb;24(3):2123-2134
N-glycosylation of uterine endometrium determines its receptivity.
Yu M, Qin H, Wang H, Liu J, Liu S, Yan Q
Journal of cellular physiology 2020 Feb;235(2):1076-1089
Journal of cellular physiology 2020 Feb;235(2):1076-1089
Pizotifen inhibits the proliferation and invasion of gastric cancer cells.
Jiang Y, Wang W, Wu X, Shi J
Experimental and therapeutic medicine 2020 Feb;19(2):817-824
Experimental and therapeutic medicine 2020 Feb;19(2):817-824
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.
Jiang W, Wu Y, He T, Zhu H, Ke G, Xiang L, Yang H
Molecular cancer therapeutics 2020 Feb;19(2):337-347
Molecular cancer therapeutics 2020 Feb;19(2):337-347
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Zhou Y, Fu X, Guan Y, Gong M, He K, Huang B
Biochemical pharmacology 2020 Feb;172:113752
Biochemical pharmacology 2020 Feb;172:113752
High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model.
Ying C, Ying L, Yanxia L, Le W, Lili C
Acta histochemica 2020 Feb;122(2):151485
Acta histochemica 2020 Feb;122(2):151485
lncRNA SNHG3 facilitates acute myeloid leukemia cell growth via the regulation of miR-758-3p/SRGN axis.
Peng L, Zhang Y, Xin H
Journal of cellular biochemistry 2020 Feb;121(2):1023-1031
Journal of cellular biochemistry 2020 Feb;121(2):1023-1031
A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis.
Cao S, Bian Y, Zhou X, Yuan Q, Wei S, Xue L, Yang F, Qianqian Dong, Wenjun Wang, Zheng B, Zhang J, Wang Z, Han Z, Yang K, Rui H, Zhang Y, Xu F, Chen Y
Biochemical and biophysical research communications 2020 Feb 5;522(2):518-524
Biochemical and biophysical research communications 2020 Feb 5;522(2):518-524
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Liu Q, Zhang S, Zhu D, Tang X, Che Y, Feng X
Behavioural brain research 2020 Feb 3;379:112337
Behavioural brain research 2020 Feb 3;379:112337
Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment.
Xie J, Li B, Yao B, Zhang P, Wang L, Lu H, Song X
Bioscience reports 2020 Feb 28;40(2)
Bioscience reports 2020 Feb 28;40(2)
Oxidative Stress and Endoplasmic Reticulum Stress Are Involved in the Protective Effect of Alpha Lipoic Acid Against Heat Damage in Chicken Testes.
Xiong Y, Yin Q, Li J, He S
Animals : an open access journal from MDPI 2020 Feb 27;10(3)
Animals : an open access journal from MDPI 2020 Feb 27;10(3)
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M, Yang G
Cell death & disease 2020 Feb 18;11(2):126
Cell death & disease 2020 Feb 18;11(2):126
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Xu C, Diao YF, Wang J, Liang J, Xu HH, Zhao ML, Zheng B, Luan Z, Wang JJ, Yang XP, Wei MG, Duan JH, Wang KQ, Chen C, Chen F, Ming D, Zhang S, Sun HT, Li XH
Stem cells and development 2020 Feb 15;29(4):222-234
Stem cells and development 2020 Feb 15;29(4):222-234
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Zhang C, Wang J, Zhu J, Chen Y, Han X
The Science of the total environment 2020 Feb 10;703:134702
The Science of the total environment 2020 Feb 10;703:134702
Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H(2)O(2)-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.
Qi L, Jiang J, Zhang J, Zhang L, Wang T
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Antioxidants (Basel, Switzerland) 2020 Feb 1;9(2)
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.
Zhu JJ, Yu BY, Fu CC, He MZ, Zhu JH, Chen BW, Zheng YH, Chen SQ, Fu XQ, Li PJ, Lin ZL
International immunopharmacology 2020 Dec;89(Pt B):107095
International immunopharmacology 2020 Dec;89(Pt B):107095
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Zeng Q, Zeng Y, Nie X, Guo Y, Zhan Y
Planta medica 2020 Dec;86(18):1401-1410
Planta medica 2020 Dec;86(18):1401-1410
Hyperbaric Oxygen Ameliorated Acute Pancreatitis in Rats via the Mitochondrial Pathway.
Zhao H, Ge B, Yuan Y, Wang G
Digestive diseases and sciences 2020 Dec;65(12):3558-3569
Digestive diseases and sciences 2020 Dec;65(12):3558-3569
Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
Gou W, Luo N, Wei H, Wu H, Yu X, Duan Y, Bi C, Ning H, Hou W, Li Y
Pharmaceutical biology 2020 Dec;58(1):707-715
Pharmaceutical biology 2020 Dec;58(1):707-715
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Yang X, Li Y, Chen L, Xu M, Wu J, Zhang P, Nel D, Sun B
Pharmaceutical biology 2020 Dec;58(1):686-694
Pharmaceutical biology 2020 Dec;58(1):686-694
Screening active components from Rubus amabilis for pancreatic β-cells protection.
Sun M, Zhu T, Tong J, Caidan R, Wang K, Kai G, Zhang W, Ru L, Pengcuo J, Tong L
Pharmaceutical biology 2020 Dec;58(1):674-685
Pharmaceutical biology 2020 Dec;58(1):674-685
Simvastatin protects high glucose-induced H9c2 cells from injury by inducing autophagy.
E L, Jiang H
Pharmaceutical biology 2020 Dec;58(1):1077-1084
Pharmaceutical biology 2020 Dec;58(1):1077-1084
PS48 promotes in vitro maturation and developmental competence of porcine oocytes through activating PI3K/Akt signalling pathway.
Jiao Y, Zhu S, Li J, Jam Zaheer A, Li M, Huang B
Reproduction in domestic animals = Zuchthygiene 2020 Dec;55(12):1678-1687
Reproduction in domestic animals = Zuchthygiene 2020 Dec;55(12):1678-1687
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.
Chen M, Ding Y, Ke Y, Zeng Y, Liu N, Zhong Y, Hua X, Li Z, Xiong Y, Wu C, Yu H
Artificial cells, nanomedicine, and biotechnology 2020 Dec;48(1):824-833
Artificial cells, nanomedicine, and biotechnology 2020 Dec;48(1):824-833
Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate-binding protein-interacting protein 1 in tongue cell carcinoma.
Xie H, Yang L, Hu Q, Song Y, Wang X, Zhou L, Li L
Head & neck 2020 Dec;42(12):3623-3637
Head & neck 2020 Dec;42(12):3623-3637
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells.
Yao X, Zhao CR, Yin H, Wang K, Gao JJ
Acta pharmacologica Sinica 2020 Dec;41(12):1609-1620
Acta pharmacologica Sinica 2020 Dec;41(12):1609-1620
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Lv J, Bao S, Liu T, Wei L, Wang D, Ye W, Wang N, Song S, Li J, Chudhary M, Ren X, Kong L
Cell and tissue research 2020 Dec;382(3):477-486
Cell and tissue research 2020 Dec;382(3):477-486
Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of Notch/Wnt/Hedgehog signaling pathways.
Hou HW, Xue P, Wang Y, Li YK
European review for medical and pharmacological sciences 2020 Dec;24(23):12408-12422
European review for medical and pharmacological sciences 2020 Dec;24(23):12408-12422
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats.
Zhao Z, Li J, Zheng B, Liang Y, Shi J, Zhang J, Han X, Chu L, Chu X, Gao Y
Molecular medicine reports 2020 Dec;22(6):5271-5281
Molecular medicine reports 2020 Dec;22(6):5271-5281
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury.
He GQ, Chen Y, Liao HJ, Xu WM, Zhang W, He GL
Molecular medicine reports 2020 Dec;22(6):5083-5094
Molecular medicine reports 2020 Dec;22(6):5083-5094
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis.
Xue Y, Li M, Xue Y, Jin W, Han X, Zhang J, Chu X, Li Z, Chu L
Molecular medicine reports 2020 Dec;22(6):4663-4674
Molecular medicine reports 2020 Dec;22(6):4663-4674
Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis.
Bi HQ, Li ZH, Zhang H
Hepatobiliary & pancreatic diseases international : HBPD INT 2020 Dec;19(6):567-574
Hepatobiliary & pancreatic diseases international : HBPD INT 2020 Dec;19(6):567-574
Synchrotron FTIR microspectroscopy revealed apoptosis-induced biomolecular changes of cholangiocarcinoma cells treated with ursolic acid.
Maphanao P, Thanan R, Loilome W, Chio-Srichan S, Wongwattanakul M, Sakonsinsiri C
Biochimica et biophysica acta. General subjects 2020 Dec;1864(12):129708
Biochimica et biophysica acta. General subjects 2020 Dec;1864(12):129708
Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway.
Wang Y, Zuo B, Wang N, Li S, Liu C, Sun D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110798
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110798
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN.
Zhang N, Liu JF
Bioengineered 2020 Dec;11(1):972-983
Bioengineered 2020 Dec;11(1):972-983
Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents.
Xu C, Zhou W, Dong G, Qiao H, Peng J, Jia P, Li Y, Liu H, Sun K, Zhao W
Bioorganic chemistry 2020 Dec;105:104424
Bioorganic chemistry 2020 Dec;105:104424
Identification and functional analyses of a cell-death inhibitor encoded by guinea pig cytomegalovirus gp38.1 in cell culture and in animals.
Noguchi K, Majima R, Takahashi K, Iwase Y, Yamada S, Satoh K, Koshizuka T, Inoue N
The Journal of general virology 2020 Dec;101(12):1270-1279
The Journal of general virology 2020 Dec;101(12):1270-1279
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells.
Xie Z, Wang F, Lin L, Duan S, Liu X, Li X, Li T, Xue M, Cheng Y, Ren H, Zhu Y
Cancer letters 2020 Dec 28;495:200-210
Cancer letters 2020 Dec 28;495:200-210
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Zhao Y, Lin Z, Lin Z, Zhou C, Liu G, Lin J, Zhang D, Lin D
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Huang D, Siaw-Debrah F, Wang H, Ye S, Wang K, Wu K, Zhang Y, Wang H, Yao C, Chen J, Yan L, Zhang CL, Zhuge Q, Yang J
Aging 2020 Dec 19;13(2):2822-2850
Aging 2020 Dec 19;13(2):2822-2850
Pharmacological activation of the p53 pathway by a new compound CYZ2017 exerts anti-tumor effects.
Han Y, Ren Z, Wu Y, Chen Y, Cui Z, Zhu T, Ma M, Du Y, Dong S
Biochemical and biophysical research communications 2020 Dec 17;533(4):1069-1075
Biochemical and biophysical research communications 2020 Dec 17;533(4):1069-1075
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Yang B, Luo G, Zhang C, Feng L, Luo X, Gan L
Scientific reports 2020 Dec 17;10(1):22204
Scientific reports 2020 Dec 17;10(1):22204
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Guan S, Tao S, Huang Y, Jin Y, Hu Y, Lu J
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Acetylcholine ameliorated TNF-α-induced primary trophoblast malfunction via muscarinic receptors†.
Wang Z, Zibrila AI, Liu S, Zhao G, Li Y, Xu J, Liu D, Li C, Feng W, Liu J
Biology of reproduction 2020 Dec 1;103(6):1238-1248
Biology of reproduction 2020 Dec 1;103(6):1238-1248
The protective effects of pretreatment with resveratrol in cyclophosphamide-induced rat ovarian granulosa cell injury: In vitro study.
Nie Z, Zhang L, Chen W, Zhang Y, Hua R, Wang W, Zhang T, Wu H
Reproductive toxicology (Elmsford, N.Y.) 2020 Aug;95:66-74
Reproductive toxicology (Elmsford, N.Y.) 2020 Aug;95:66-74
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Han J, Kan J, Wang X, Yuan Q, Song X, Huang M, Wu H
Translational cancer research 2020 Aug;9(8):4715-4725
Translational cancer research 2020 Aug;9(8):4715-4725
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.
Zhang L, Wang Z, Kong D, Zhao X, Chen X, Chai W
Bioscience, biotechnology, and biochemistry 2020 Aug;84(8):1603-1613
Bioscience, biotechnology, and biochemistry 2020 Aug;84(8):1603-1613
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Su Q, Wang J, Liu F, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis.
Yang YX, Yu S, Jia BX, Liu N, Wu A
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104838
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104838
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
Cui Y, Yang D, Wang W, Zhang L, Liu H, Ma S, Guo W, Yao M, Zhang K, Li W, Zhang Y, Guan F
Molecular carcinogenesis 2020 Aug;59(8):940-954
Molecular carcinogenesis 2020 Aug;59(8):940-954
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, Han L, Xin X, Wang H, Lin D, Peng F, Yu F, Zheng C, Shen C
Cell proliferation 2020 Aug;53(8):e12869
Cell proliferation 2020 Aug;53(8):e12869
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Che H, He W, Feng J, Dong W, Liu S, Chen T, Ge S, Zhou J, Liang C
Cell biochemistry and function 2020 Aug;38(6):695-701
Cell biochemistry and function 2020 Aug;38(6):695-701
Functional characterization of the long noncoding RNA MIR22HG as a tumour suppressor in cervical cancer by targeting IGF2BP2.
Shu J, Wang D
European review for medical and pharmacological sciences 2020 Aug;24(15):7953-7962
European review for medical and pharmacological sciences 2020 Aug;24(15):7953-7962
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats.
Zhang X, Fan X, Li F, Qiu J, Zhang Y
Molecular medicine reports 2020 Aug;22(2):1391-1399
Molecular medicine reports 2020 Aug;22(2):1391-1399
Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway.
Zhang J, Fan J
Experimental and therapeutic medicine 2020 Aug;20(2):1145-1152
Experimental and therapeutic medicine 2020 Aug;20(2):1145-1152
Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration.
Guo Y, Zhu H, Weng M, Chen B, Wang C, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110366
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110366
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.
Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y, Piao D
The international journal of biochemistry & cell biology 2020 Aug;125:105777
The international journal of biochemistry & cell biology 2020 Aug;125:105777
Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit.
Wu J, He J, Tian X, Zhong J, Li H, Sun X
Translational stroke research 2020 Aug;11(4):720-733
Translational stroke research 2020 Aug;11(4):720-733
Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
Zhang X, Zhang P, An L, Sun N, Peng L, Tang W, Ma D, Chen J
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
Acta pharmaceutica Sinica. B 2020 Aug;10(8):1397-1413
IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes.
Yang X, Guo Q, Feng T, Lu Q, Ge L, Pan J, Bi K, Qiao L, Tian L, Xie T, Yao C, Song G, Wang L
Arthritis research & therapy 2020 Aug 8;22(1):184
Arthritis research & therapy 2020 Aug 8;22(1):184
RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Xu Y, Sun Q, Yuan F, Dong H, Zhang H, Geng R, Qi Y, Xiong X, Chen Q, Liu B
Journal of experimental & clinical cancer research : CR 2020 Aug 31;39(1):174
Journal of experimental & clinical cancer research : CR 2020 Aug 31;39(1):174
Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation.
Liu F, Kalpage HA, Wang D, Edwards H, Hüttemann M, Ma J, Su Y, Carter J, Li X, Polin L, Kushner J, Dzinic SH, White K, Wang G, Taub JW, Ge Y
Cancers 2020 Aug 24;12(9)
Cancers 2020 Aug 24;12(9)
A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy.
Zhang R, Zhang L, Ran H, Li P, Huang J, Tan M, Yang Y, Wang Z
Biomaterials science 2020 Aug 21;8(16):4581-4594
Biomaterials science 2020 Aug 21;8(16):4581-4594
Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.
Liu X, Zhou C, Li Y, Deng Y, Lu W, Li J
Gene 2020 Aug 15;751:144726
Gene 2020 Aug 15;751:144726
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D
Life sciences 2020 Aug 15;255:117719
Life sciences 2020 Aug 15;255:117719
Upregulation of miRNA-9-5p Promotes Angiogenesis after Traumatic Brain Injury by Inhibiting Ptch-1.
Wu J, He J, Tian X, Li H, Wen Y, Shao Q, Cheng C, Wang G, Sun X
Neuroscience 2020 Aug 1;440:160-174
Neuroscience 2020 Aug 1;440:160-174
Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.
Liu Q, Tan Y, Qu T, Zhang J, Duan X, Xu H, Mu Y, Ma H, Wang F
Life sciences 2020 Aug 1;254:117772
Life sciences 2020 Aug 1;254:117772
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis.
Luo J, Yang C, Luo X, Yang Y, Li J, Song B, Zhao J, Li L
Life sciences 2020 Aug 1;254:117590
Life sciences 2020 Aug 1;254:117590
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y, Yu J
Life sciences 2020 Aug 1;254:116444
Life sciences 2020 Aug 1;254:116444
MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer.
Liu W, Li Y, Feng S, Guan Y, Cao Y
Journal of biochemistry 2020 Aug 1;168(2):159-170
Journal of biochemistry 2020 Aug 1;168(2):159-170
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Guo H, He J, Yang X, Zheng W, Yao W
Journal of thermal biology 2020 Apr;89:102539
Journal of thermal biology 2020 Apr;89:102539
Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy.
Guo X, Zhang Y, Lu C, Qu F, Jiang X
Bioscience, biotechnology, and biochemistry 2020 Apr;84(4):714-724
Bioscience, biotechnology, and biochemistry 2020 Apr;84(4):714-724
RETRACTED: MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway.
Ouyang H, Tan Y, Li Q, Xia F, Xiao X, Zheng S, Lu J, Zhong J, Hu Y
International immunopharmacology 2020 Apr;81:106204
International immunopharmacology 2020 Apr;81:106204
Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1α/MAPK signaling pathway.
Guan R, Wang J, Li D, Li Z, Liu H, Ding M, Cai Z, Liang X, Yang Q, Long Z, Chen L, Liu W, Sun D, Yao H, Lu W
International immunopharmacology 2020 Apr;81:105979
International immunopharmacology 2020 Apr;81:105979
MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4.
Cui Z, Bao X, Liu Q, Li Q, Huang L, Wang H, Jiao K
Clinical and experimental pharmacology & physiology 2020 Apr;47(4):713-724
Clinical and experimental pharmacology & physiology 2020 Apr;47(4):713-724
CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells.
Sun S, Cui Z, Yan T, Wu J, Liu Z
Cell biology international 2020 Apr;44(4):998-1008
Cell biology international 2020 Apr;44(4):998-1008
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Bu T, Wang C, Jin H, Meng Q, Huo X, Sun H, Sun P, Wu J, Ma X, Liu Z, Liu K
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Shi L, Duan Y, Yao X, Song R, Ren Y
Animal reproduction science 2020 Apr;215:106330
Animal reproduction science 2020 Apr;215:106330
Estradiol-17β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1.
An SY, Gao XX, Wang ZB, Liang YX, Wang ST, Xiao SH, Xia JT, You PH, Wang F, Zhang GM
Animal reproduction science 2020 Apr;215:106328
Animal reproduction science 2020 Apr;215:106328
METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway.
Liang S, Guan H, Lin X, Li N, Geng F, Li J
Oncology letters 2020 Apr;19(4):3197-3204
Oncology letters 2020 Apr;19(4):3197-3204
Effects of photoelectric therapy on proliferation and apoptosis of scar cells by regulating the expression of microRNA-206 and its related mechanisms.
Zhang S, Zhao ZM, Xue HY, Nie FF
International wound journal 2020 Apr;17(2):317-325
International wound journal 2020 Apr;17(2):317-325
Novel nortriterpenoids with new skeletons and limonoids from the fruits of Evodia rutaecarpa and their bioactivities.
Shi YS, Xia HM, Wu CH, Li CB, Duan CC, Che C, Zhang XJ, Li HT, Zhang Y, Zhang XF
Fitoterapia 2020 Apr;142:104503
Fitoterapia 2020 Apr;142:104503
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Sun X, Yang S, Song W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Targeting BAX ubiquitin-binding sites reveals that BAX activation is essential for its ubiquitin-dependent degradation.
Peng R, Zhu J, Deng S, Shi H, Xu S, Wu H, Zou F
Journal of cellular biochemistry 2020 Apr;121(4):2802-2810
Journal of cellular biochemistry 2020 Apr;121(4):2802-2810
Exogenous H(2)S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8.
Zhang C, Xie X, Yuan Y, Wang Y, Zhou M, Li X, Zhen P
Dose-response : a publication of International Hormesis Society 2020 Apr-Jun;18(2):1559325820929234
Dose-response : a publication of International Hormesis Society 2020 Apr-Jun;18(2):1559325820929234
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21(WAF1/CIP1).
Miao J, Xu M, Kuang Y, Pan S, Hou J, Cao P, Duan X, Chang Y, Hasem H, Zhou N, Tan K, Fan Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):736-743
Biochemical and biophysical research communications 2020 Apr 9;524(3):736-743
Qi Dan Li Xin pill improves chronic heart failure by regulating mTOR/p70S6k-mediated autophagy and inhibiting apoptosis.
Shi B, Huang Y, Ni J, Chen J, Wei J, Gao H, Li L, Zhou Z, Wang Y, Xu Y, Xu Z, Mao J, Fan G
Scientific reports 2020 Apr 8;10(1):6105
Scientific reports 2020 Apr 8;10(1):6105
Protocadherin 8 (PCDH8) Inhibits Proliferation, Migration, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma.
Yu H, Jiang X, Jiang L, Zhou H, Bao J, Zhu X, Liu F, Huang J
Medical science monitor : international medical journal of experimental and clinical research 2020 Apr 24;26:e920665
Medical science monitor : international medical journal of experimental and clinical research 2020 Apr 24;26:e920665
Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene.
Huang G, Ma J, Zhang L
Medical science monitor : international medical journal of experimental and clinical research 2020 Apr 19;26:e920623
Medical science monitor : international medical journal of experimental and clinical research 2020 Apr 19;26:e920623
Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.
Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes.
Chen Z, Yuan SJ, Li K, Zhang Q, Li TF, An HC, Xu HZ, Yue Y, Han M, Xu YH, Komatsu N, Zhao L, Chen X
Journal of controlled release : official journal of the Controlled Release Society 2020 Apr 10;320:469-483
Journal of controlled release : official journal of the Controlled Release Society 2020 Apr 10;320:469-483
Bishonokiol A Induces Multiple Cell Death in Human Breast Cancer MCF-7 Cells.
Li HM, Li B, Ma H, Sun X, Zhu M, Dai Y, Ma T, Huo Q, Wu CZ
Asian Pacific journal of cancer prevention : APJCP 2020 Apr 1;21(4):1073-1080
Asian Pacific journal of cancer prevention : APJCP 2020 Apr 1;21(4):1073-1080
Selenium ameliorates cadmium-induced mouse leydig TM3 cell apoptosis via inhibiting the ROS/JNK /c-jun signaling pathway.
Ren X, Wang S, Zhang C, Hu X, Zhou L, Li Y, Xu L
Ecotoxicology and environmental safety 2020 Apr 1;192:110266
Ecotoxicology and environmental safety 2020 Apr 1;192:110266
MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.
Tong Q, Ouyang S, Chen R, Huang J, Guo L
American journal of cancer research 2019;9(9):1938-1956
American journal of cancer research 2019;9(9):1938-1956
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.
Zhao WS, Yan WP, Chen DB, Dai L, Yang YB, Kang XZ, Fu H, Chen P, Deng KJ, Wang XY, Xie XW, Chen HS, Chen KN
American journal of cancer research 2019;9(6):1183-1200
American journal of cancer research 2019;9(6):1183-1200
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer.
Zhang H, Chen R, Wang X, Zhang H, Zhu X, Chen J
Frontiers in oncology 2019;9:538
Frontiers in oncology 2019;9:538
Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets.
Wang H, Lu Y, Yan Y, Tian S, Zheng D, Leng D, Wang C, Jiao J, Wang Z, Bai Y
Frontiers in cellular and infection microbiology 2019;9:455
Frontiers in cellular and infection microbiology 2019;9:455
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.
Feng X, Yan N, Sun W, Zheng S, Jiang S, Wang J, Guo C, Hao L, Tian Y, Liu S, Sun MZ
Cell death discovery 2019;5:89
Cell death discovery 2019;5:89
Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.
Zhang W, Yang Y, Gao H, Zhang Y, Jia Z, Huang S
Kidney & blood pressure research 2019;44(5):1002-1013
Kidney & blood pressure research 2019;44(5):1002-1013
Cinobufagin Promotes Cell Cycle Arrest and Apoptosis to Block Human Esophageal Squamous Cell Carcinoma Cells Growth via the p73 Signalling Pathway.
Deng X, Sheng J, Liu H, Wang N, Dai C, Wang Z, Zhang J, Zhao J, Dai E
Biological & pharmaceutical bulletin 2019;42(9):1500-1509
Biological & pharmaceutical bulletin 2019;42(9):1500-1509
Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
Tu Y, Li L, Qin B, Wu J, Cheng T, Kang L, Guan H
Molecular vision 2019;25:734-744
Molecular vision 2019;25:734-744
Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.
Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z, Xu J, Zhang Y, Li L
Stem cells international 2019;2019:8035076
Stem cells international 2019;2019:8035076
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z
Oxidative medicine and cellular longevity 2019;2019:6521218
Oxidative medicine and cellular longevity 2019;2019:6521218
UFL1 Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4/NF-κB Pathway in Bovine Mammary Epithelial Cells.
Li C, Li L, Chen K, Wang Y, Yang F, Wang G
Oxidative medicine and cellular longevity 2019;2019:6505373
Oxidative medicine and cellular longevity 2019;2019:6505373
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Wang Z, Li C, Li Y, Guo X, Yan Z, Gao F, Li C
Oxidative medicine and cellular longevity 2019;2019:5414670
Oxidative medicine and cellular longevity 2019;2019:5414670
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, Wang L, Yan J, Nikolaevna SE, Zhao Y
Oxidative medicine and cellular longevity 2019;2019:5406468
Oxidative medicine and cellular longevity 2019;2019:5406468
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Tong Y, Dong Y, Feng Y, Li Z, Jia Y, Zhang X, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:4929107
Oxidative medicine and cellular longevity 2019;2019:4929107
MicroRNA-155 Promotes Myocardial Infarction-Induced Apoptosis by Targeting RNA-Binding Protein QKI.
Guo J, Liu HB, Sun C, Yan XQ, Hu J, Yu J, Yuan Y, Du ZM
Oxidative medicine and cellular longevity 2019;2019:4579806
Oxidative medicine and cellular longevity 2019;2019:4579806
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro.
Du Y, Qian B, Gao L, Tan P, Chen H, Wang A, Zheng T, Pu S, Xia X, Fu W
Oxidative medicine and cellular longevity 2019;2019:3765898
Oxidative medicine and cellular longevity 2019;2019:3765898
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Ji L, Wang Q, Huang F, An T, Guo F, Zhao Y, Liu Y, He Y, Song Y, Qin G
Oxidative medicine and cellular longevity 2019;2019:3286928
Oxidative medicine and cellular longevity 2019;2019:3286928
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Wang W, Wu L, Li J, Ji J, Chen K, Yu Q, Li S, Feng J, Liu T, Zhang J, Chen J, Zhou Y, Mao Y, Wang F, Dai W, Fan X, Guo C, Wu J
Mediators of inflammation 2019;2019:3240713
Mediators of inflammation 2019;2019:3240713
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence.
Wei J, Zhao B, Zhang C, Shen B, Zhang Y, Li C, Chen Y
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2360367
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2360367
Polysaccharides of Fructus corni Improve Ovarian Function in Mice with Aging-Associated Perimenopause Symptoms.
Wang Y, Wu JZ, Li Y, Qi X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2089586
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2089586
Inhibition of LINC00994 represses malignant behaviors of pancreatic cancer cells: interacting with miR-765-3p/RUNX2 axis.
Zhu X, Niu X, Ge C
Cancer biology & therapy 2019;20(6):799-811
Cancer biology & therapy 2019;20(6):799-811
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.
Wu D, Liu Z, Li J, Zhang Q, Zhong P, Teng T, Chen M, Xie Z, Ji A, Li Y
Cancer cell international 2019;19:43
Cancer cell international 2019;19:43
Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells.
Liu S, Li J, Kang L, Tian Y, Xue Y
Cancer cell international 2019;19:349
Cancer cell international 2019;19:349
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.
Ye Z, Duan J, Wang L, Ji Y, Qiao B
Cancer cell international 2019;19:311
Cancer cell international 2019;19:311
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Li Y, Wang C, Lu J, Huang K, Han Y, Chen J, Yang Y, Liu B
International journal of medical sciences 2019;16(12):1593-1603
International journal of medical sciences 2019;16(12):1593-1603
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582
International journal of medical sciences 2019;16(12):1573-1582
RRM2 is a potential prognostic biomarker with functional significance in glioma.
Sun H, Yang B, Zhang H, Song J, Zhang Y, Xing J, Yang Z, Wei C, Xu T, Yu Z, Xu Z, Hou M, Ji M, Zhang Y
International journal of biological sciences 2019;15(3):533-543
International journal of biological sciences 2019;15(3):533-543
Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis.
Li J, Tang M, Yang G, Wang L, Gao Q, Zhang H
International journal of biological sciences 2019;15(12):2584-2595
International journal of biological sciences 2019;15(12):2584-2595
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771
International journal of nanomedicine 2019;14:3753-3771
Treatment With 2-BFI Attenuated Spinal Cord Injury by Inhibiting Oxidative Stress and Neuronal Apoptosis via the Nrf2 Signaling Pathway.
Lin X, Zhu J, Ni H, Rui Q, Sha W, Yang H, Li D, Chen G
Frontiers in cellular neuroscience 2019;13:567
Frontiers in cellular neuroscience 2019;13:567
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway.
Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D
Drug design, development and therapy 2019;13:4145-4157
Drug design, development and therapy 2019;13:4145-4157
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway.
Wang Y, Shao Y, Gao Y, Wan G, Wan D, Zhu H, Qiu Y, Ye X
Drug design, development and therapy 2019;13:243-253
Drug design, development and therapy 2019;13:243-253
Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT.
Wei Y, Lv B, Xie J, Zhang Y, Lin Y, Wang S, Zhong J, Chen Y, Peng Y, Ma J
Drug design, development and therapy 2019;13:2343-2355
Drug design, development and therapy 2019;13:2343-2355
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Xu B, Sui YL, Fan TJ
International journal of ophthalmology 2019;12(10):1524-1530
International journal of ophthalmology 2019;12(10):1524-1530
TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ.
Yang Y, Fan J, Han S, Li E
OncoTargets and therapy 2019;12:9861-9871
OncoTargets and therapy 2019;12:9861-9871
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.
He Z, Yu L, Luo S, Li Q, Huang S, An Y
OncoTargets and therapy 2019;12:8701-8714
OncoTargets and therapy 2019;12:8701-8714
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells.
Shi S, Zheng G, Yang C, Chen X, Yan Q, Jiang F, Jiang X, Xin Y, Jiang G
OncoTargets and therapy 2019;12:11715-11727
OncoTargets and therapy 2019;12:11715-11727
DHT deteriorates the progression of monocrotaline-induced pulmonary arterial hypertension: effects of endogenous and exogenous androgen.
Wen J, Wang J, Tang X, Deng S, Dai J, Li X, Cai W
American journal of translational research 2019;11(9):5752-5763
American journal of translational research 2019;11(9):5752-5763
Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol.
Xu Y, Yao S, Gao D, Li W, Zheng D, Zhang Q
American journal of translational research 2019;11(5):3039-3047
American journal of translational research 2019;11(5):3039-3047
Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt/mTOR pathway and regulating BDNF and PTEN expression.
Zhu H, Wang Y, Yang X, Wan G, Qiu Y, Ye X, Gao Y, Wan D
American journal of translational research 2019;11(3):1311-1326
American journal of translational research 2019;11(3):1311-1326
The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.
Cao X, He Y, Li X, Xu Y, Liu X
American journal of translational research 2019;11(2):641-654
American journal of translational research 2019;11(2):641-654
Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies.
Jiang J, Wang X, Gao G, Liu X, Chang H, Xiong R, Lu J, Sun Z
American journal of translational research 2019;11(10):6382-6392
American journal of translational research 2019;11(10):6382-6392
TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.
Nie X, Liu C, Guo Q, Zheng MJ, Gao LL, Li X, Liu DW, Zhu LC, Liu JJ, Lin B
Cancer management and research 2019;11:839-855
Cancer management and research 2019;11:839-855
BHLHE41 promotes U87 and U251 cell proliferation via ERK/cyclinD1 signaling pathway.
Wang C, Zhao N, Zheng Q, Zhang D, Liu Y
Cancer management and research 2019;11:7657-7672
Cancer management and research 2019;11:7657-7672
UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway.
Ye Y, Huang S, Wu Y
Cancer management and research 2019;11:2339-2348
Cancer management and research 2019;11:2339-2348
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, Liu Z, Zheng M, Wang H, Wang J, Teng T, Zhang L, Ji X, Xie Z, Ji A, Li Y
Journal of Cancer 2019;10(7):1693-1706
Journal of Cancer 2019;10(7):1693-1706
Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin.
Peng Y, Wang L, Wu L, Zhang L, Nie G, Guo M
Journal of Cancer 2019;10(24):6124-6134
Journal of Cancer 2019;10(24):6124-6134
A Novel Resveratrol-Arsenic Trioxide Combination Treatment Synergistically Induces Apoptosis of Adriamycin-Selected Drug-Resistant Leukemia K562 Cells.
Chen J, Tian B, Zhou C, Sun J, Lin L, Jin S, Liu Q, Fu S, Liu L, Liu H, Zhang Z, Li C, Wei H
Journal of Cancer 2019;10(22):5483-5493
Journal of Cancer 2019;10(22):5483-5493
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
Zhang R, Wang C, Tian Y, Yao Y, Mao J, Wang H, Li Z, Xu Y, Ye M, Wang L
Journal of Cancer 2019;10(16):3871-3882
Journal of Cancer 2019;10(16):3871-3882
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.
Zhao C, He R, Shen M, Zhu F, Wang M, Liu Y, Chen H, Li X, Qin R
Frontiers in pharmacology 2019;10:968
Frontiers in pharmacology 2019;10:968
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Lin J, Jiao A, Lv W, Zhang C, Shi Y, Yang Z, Sun N, Li X, Zhang J
Frontiers in pharmacology 2019;10:896
Frontiers in pharmacology 2019;10:896
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Wang Y, Wang B, Qi X, Zhang X, Ren K
Frontiers in pharmacology 2019;10:833
Frontiers in pharmacology 2019;10:833
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy.
Ye J, Xue M, Liu Y, Zhu S, Li Y, Liu X, Cai D, Rui J, Zhang L
Frontiers in pharmacology 2019;10:676
Frontiers in pharmacology 2019;10:676
Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways.
Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, Guo F, Ye Y
Frontiers in pharmacology 2019;10:163
Frontiers in pharmacology 2019;10:163
Seneca Valley Virus 2C and 3C(pro) Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway.
Liu T, Li X, Wu M, Qin L, Chen H, Qian P
Frontiers in microbiology 2019;10:1202
Frontiers in microbiology 2019;10:1202
Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression.
Li H, Chen W, Chen Y, Zhou Q, Xiao P, Tang R, Xue J
Frontiers in pharmacology 2019;10:1197
Frontiers in pharmacology 2019;10:1197
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Prazosin inhibits the growth and mobility of osteosarcoma cells.
An M, Ma WH, Jia HW, Li YW, Feng JJ, Meng J, Qi H, Liu J
Translational cancer research 2019 Sep;8(5):1997-2004
Translational cancer research 2019 Sep;8(5):1997-2004
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, Zhang Y
Cancer medicine 2019 Sep;8(12):5750-5759
Cancer medicine 2019 Sep;8(12):5750-5759
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
Xin C, Lu S, Li Y, Zhang Y, Tian J, Zhang S, Yang S, Gao T, Xu J
DNA and cell biology 2019 Sep;38(9):996-1004
DNA and cell biology 2019 Sep;38(9):996-1004
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.
Li E, Zhang T, Sun X, Li Y, Geng H, Yu D, Zhong C
Oncology letters 2019 Sep;18(3):3081-3091
Oncology letters 2019 Sep;18(3):3081-3091
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Chen L, Tian Q, Wang W
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
The protective role of microRNA-140-5p in synovial injury of rats with knee osteoarthritis via inactivating the TLR4/Myd88/NF-κB signaling pathway.
Huang X, Qiao F, Xue P
Cell cycle (Georgetown, Tex.) 2019 Sep;18(18):2344-2358
Cell cycle (Georgetown, Tex.) 2019 Sep;18(18):2344-2358
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
Xu S, Ma H, Bo Y, Shao M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109080
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109080
Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia.
Cui K, Luan Y, Tang Z, Li CC, Wang T, Wang SG, Chen Z, Liu JH
Asian journal of andrology 2019 Sep-Oct;21(5):508-515
Asian journal of andrology 2019 Sep-Oct;21(5):508-515
IFN-γ restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Yin H, Jiang Z, Wang S, Zhang P
Cell death & disease 2019 Sep 9;10(9):642
Cell death & disease 2019 Sep 9;10(9):642
Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel.
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, Zhao H, Ke J, Wu S, Wang X, Wu F
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Biochemical and biophysical research communications 2019 Sep 3;516(4):1066-1072
Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.
Zhan S, Wang K, Song Y, Li S, Yin H, Luo R, Liao Z, Wu X, Zhang Y, Yang C
Arthritis research & therapy 2019 Sep 3;21(1):201
Arthritis research & therapy 2019 Sep 3;21(1):201
Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma.
Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, Gu Y, Sun H, Liang P
Cell death & disease 2019 Sep 26;10(10):717
Cell death & disease 2019 Sep 26;10(10):717
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
A dual-enzymatically cross-linked injectable gelatin hydrogel loaded with BMSC improves neurological function recovery of traumatic brain injury in rats.
Yao M, Gao F, Xu R, Zhang J, Chen Y, Guan F
Biomaterials science 2019 Sep 24;7(10):4088-4098
Biomaterials science 2019 Sep 24;7(10):4088-4098
Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway.
Wang Y, Zuo R, Wang Z, Luo L, Wu J, Zhang C, Liu M, Shi C, Zhou Y
Aging 2019 Sep 23;11(18):7961-7977
Aging 2019 Sep 23;11(18):7961-7977
Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation.
Su YT, Guo YB, Cheng YP, Zhang X, Xie XP, Chang YM, Bao JX
International journal of molecular sciences 2019 Sep 20;20(19)
International journal of molecular sciences 2019 Sep 20;20(19)
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis.
Bao Q, Yang D, Hong F, Yang J, Li L, Jin Y, Ma C
Experimental cell research 2019 Sep 15;382(2):111459
Experimental cell research 2019 Sep 15;382(2):111459
Cypermethrin exposure reduces the ovarian reserve by causing mitochondrial dysfunction in granulosa cells.
Wang H, He Y, Cheng D, Pu D, Tan R, Gao L, Cui Y, Wu J
Toxicology and applied pharmacology 2019 Sep 15;379:114693
Toxicology and applied pharmacology 2019 Sep 15;379:114693
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Liu C, Cui Y, Pi F, Guo Y, Cheng Y, Qian H
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
Xu WN, Yang RZ, Zheng HL, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
International journal of biological macromolecules 2019 Sep 1;136:1007-1017
International journal of biological macromolecules 2019 Sep 1;136:1007-1017
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Geng F, Fan MJ, Li J, Liang SM, Li CY, Li N
Translational cancer research 2019 Oct;8(6):2307-2315
Translational cancer research 2019 Oct;8(6):2307-2315
Radiation induces apoptosis primarily through the intrinsic pathway in mammalian cells.
Cao X, Wen P, Fu Y, Gao Y, Qi X, Chen B, Tao Y, Wu L, Xu A, Lu H, Zhao G
Cellular signalling 2019 Oct;62:109337
Cellular signalling 2019 Oct;62:109337
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L
International journal of oncology 2019 Oct;55(4):879-895
International journal of oncology 2019 Oct;55(4):879-895
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z
Cancer research and treatment 2019 Oct;51(4):1653-1665
Cancer research and treatment 2019 Oct;51(4):1653-1665
The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro.
Cao T, Xu R, Xu Y, Liu Y, Qi D, Wan Q
International urology and nephrology 2019 Oct;51(10):1883-1892
International urology and nephrology 2019 Oct;51(10):1883-1892
Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways.
Shang H, Cao Z, Zhao J, Guan J, Liu J, Peng J, Chen Y, Joseph Sferra T, Sankararaman S, Lin J
The Journal of international medical research 2019 Oct;47(10):5106-5119
The Journal of international medical research 2019 Oct;47(10):5106-5119
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y, Guan F
Molecular and cellular biochemistry 2019 Oct;460(1-2):93-103
Molecular and cellular biochemistry 2019 Oct;460(1-2):93-103
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
He Z, Du X, Wu Y, Hua L, Wan L, Yan N
International journal of molecular medicine 2019 Oct;44(4):1289-1298
International journal of molecular medicine 2019 Oct;44(4):1289-1298
Linc01105 acts as an oncogene in the development of neuroblastoma.
Ye M, Ma J, Liu B, Liu X, Ma D, Dong K
Oncology reports 2019 Oct;42(4):1527-1538
Oncology reports 2019 Oct;42(4):1527-1538
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y
Oncology reports 2019 Oct;42(4):1451-1458
Oncology reports 2019 Oct;42(4):1451-1458
Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer.
Hu P, Fang D, Shen L, Zhou H, Shao R, Chen M, Yao C, Shi Y, Chen Q
Journal of biomaterials applications 2019 Oct;34(4):509-522
Journal of biomaterials applications 2019 Oct;34(4):509-522
Genistein inhibits nasopharyngeal cancer stem cells through sonic hedgehog signaling.
Zhang Q, Cao WS, Wang XQ, Zhang M, Lu XM, Chen JQ, Chen Y, Ge MM, Zhong CY, Han HY
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791
Phytotherapy research : PTR 2019 Oct;33(10):2783-2791
LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma.
Luo XF, Wu XJ, Wei X, Wang AG, Wang SH, Wang JL
European review for medical and pharmacological sciences 2019 Oct;23(20):8751-8760
European review for medical and pharmacological sciences 2019 Oct;23(20):8751-8760
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.
Liu Y, Fan D
Biochemical pharmacology 2019 Oct;168:285-304
Biochemical pharmacology 2019 Oct;168:285-304
Protective effect of 4-Methoxy benzyl alcohol on the neurovascular unit after cerebral ischemia reperfusion injury.
He F, Dai R, Zhou X, Li X, Song X, Yan H, Meng Q, Yang C, Lin Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109260
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109260
Qingjie Fuzheng Granule attenuates 5-fluorouracil-induced intestinal mucosal damage.
Zhang L, Jin Y, Peng J, Chen W, Lisha L, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109223
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109223
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R
Cell reports 2019 Oct 29;29(5):1261-1273.e6
Cell reports 2019 Oct 29;29(5):1261-1273.e6
Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Zhang J, Yao D, Song Y, Pan Y, Zhu L, Bai Y, Xu Y, Zhang J, Shao C
Scientific reports 2019 Oct 23;9(1):15221
Scientific reports 2019 Oct 23;9(1):15221
Induction of Chemerin on Autophagy and Apoptosis in Dairy Cow Mammary Epithelial Cells.
Hu B, Song W, Tang Y, Shi M, Li H, Yu D
Animals : an open access journal from MDPI 2019 Oct 21;9(10)
Animals : an open access journal from MDPI 2019 Oct 21;9(10)
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Li H, Tong X, Xu Y, Wang M, Dai H, Shi T, Sun M, Chen K, Cheng X, Wei Q
Carcinogenesis 2019 Oct 16;40(10):1209-1219
Carcinogenesis 2019 Oct 16;40(10):1209-1219
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro.
Liu T, Zong S, Luo P, Qu Y, Wen Y, Du P, Xiao H
Toxicology letters 2019 Oct 1;313:11-18
Toxicology letters 2019 Oct 1;313:11-18
Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia.
Zhao J, Peng W, Ran Y, Ge H, Zhang C, Zou H, Ding Y, Qi H
Journal of physiology and biochemistry 2019 Nov;75(4):475-487
Journal of physiology and biochemistry 2019 Nov;75(4):475-487
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Hua S, Liu J, Zhang Y, Li J, Zhang X, Dong L, Zhao Y, Fu X
Food science & nutrition 2019 Nov;7(11):3443-3451
Food science & nutrition 2019 Nov;7(11):3443-3451
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis.
Geng N, Zheng X, Wu M, Yang L, Li X, Chen J
Oncology reports 2019 Nov;42(5):2108-2116
Oncology reports 2019 Nov;42(5):2108-2116
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis.
Gong DJ, Wang L, Yang YY, Zhang JJ, Liu XH
Renal failure 2019 Nov;41(1):750-761
Renal failure 2019 Nov;41(1):750-761
Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice.
Huang ZB, Zheng YX, Li N, Cai SL, Huang Y, Wang J, Hu XW, Wang Y, Wu J, Fan XG
Acta pharmacologica Sinica 2019 Nov;40(11):1404-1411
Acta pharmacologica Sinica 2019 Nov;40(11):1404-1411
FoxD2-AS1 is a prognostic factor in glioma and promotes temozolomide resistance in a O(6)-methylguanine-DNA methyltransferase-dependent manner.
Shangguan W, Lv X, Tian N
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2019 Nov;23(6):475-482
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2019 Nov;23(6):475-482
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, Cui H, Xiao Y
Molecular medicine reports 2019 Nov;20(5):4551-4557
Molecular medicine reports 2019 Nov;20(5):4551-4557
Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1.
Feng X, Xiong W, Yuan M, Zhan J, Zhu X, Wei Z, Chen X, Cheng X
Cell cycle (Georgetown, Tex.) 2019 Nov;18(22):3206-3222
Cell cycle (Georgetown, Tex.) 2019 Nov;18(22):3206-3222
MicroRNA-129-5p alleviates nerve injury and inflammatory response of Alzheimer's disease via downregulating SOX6.
Zeng Z, Liu Y, Zheng W, Liu L, Yin H, Zhang S, Bai H, Hua L, Wang S, Wang Z, Li X, Xiao J, Yuan Q, Wang Y
Cell cycle (Georgetown, Tex.) 2019 Nov;18(22):3095-3110
Cell cycle (Georgetown, Tex.) 2019 Nov;18(22):3095-3110
Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway.
Huo T, Jia Y, Yin C, Luo X, Zhao J, Wang Z, Lv P
Brain research bulletin 2019 Nov;153:305-313
Brain research bulletin 2019 Nov;153:305-313
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
He GQ, Xu WM, Liao HJ, Jiang C, Li CQ, Zhang W
Neural regeneration research 2019 Nov;14(11):1977-1985
Neural regeneration research 2019 Nov;14(11):1977-1985
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Zeng Q, He S, Zhong L, Wang L, Cheng F, Zhang H, Hui J, Wei A
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.
Zhu X, Yu H, Li B, Quan J, Zeng Z, Li G, Liu J
Bioscience reports 2019 Nov 29;39(11)
Bioscience reports 2019 Nov 29;39(11)
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F
Aging 2019 Nov 26;11(22):10513-10531
Aging 2019 Nov 26;11(22):10513-10531
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Xu WN, Zheng HL, Yang RZ, Liu T, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
Mo D, Tian W, Zhang HN, Feng YD, Sun Y, Quan W, Hao XW, Wang XY, Liu XX, Li C, Cao W, Liu WJ, Li XQ
European journal of pharmacology 2019 Nov 15;863:172701
European journal of pharmacology 2019 Nov 15;863:172701
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Shen J, Wang J, Du J, Wang L, Zhou X, Chang X, Li Z, Zhai X, Zuo D, Wu Y
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Wang G, Zhao L, Lin H, Wang Y, Taub JW, Ge Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Response of the maternal hypothalamus to cold stress during late pregnancy in rats.
Wang D, Xu B, Wang J, Wang H, Guo J, Ji H, Li S, Wu R, Yang H, Lian S
Brain research 2019 Nov 1;1722:146354
Brain research 2019 Nov 1;1722:146354
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Peng XP, Li XH, Li Y, Huang XT, Luo ZQ
International immunopharmacology 2019 May;70:520-529
International immunopharmacology 2019 May;70:520-529
Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway.
Yu Q, Wu L, Liu T, Li S, Feng J, Mao Y, Fan X, Guo C, Wu J
International immunopharmacology 2019 May;70:435-445
International immunopharmacology 2019 May;70:435-445
Activation of Nrf2 signaling by Icariin protects against 6-OHDA-induced neurotoxicity.
Zhu L, Li D, Chen C, Wang G, Shi J, Zhang F
Biotechnology and applied biochemistry 2019 May;66(3):465-471
Biotechnology and applied biochemistry 2019 May;66(3):465-471
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Yin B, Hou XW, Lu ML
Acta pharmacologica Sinica 2019 May;40(5):599-607
Acta pharmacologica Sinica 2019 May;40(5):599-607
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S, Yan Q
Journal of cellular physiology 2019 May;234(5):7435-7447
Journal of cellular physiology 2019 May;234(5):7435-7447
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Fan J, Wu M, Wang J, Ren D, Zhao J, Yang G
Journal of cellular physiology 2019 May;234(5):6336-6349
Journal of cellular physiology 2019 May;234(5):6336-6349
Establishment and characterization of a radiation-induced dermatitis rat model.
Sheng X, Zhou Y, Wang H, Shen Y, Liao Q, Rao Z, Deng F, Xie L, Yao C, Mao H, Liu Z, Peng M, Long Y, Zeng Y, Xue L, Gao N, Kong Y, Zhou X
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.
Wu W, He K, Guo Q, Chen J, Zhang M, Huang K, Yang D, Wu L, Deng Y, Luo X, Yu H, Ding Q, Xiang G
Journal of cellular and molecular medicine 2019 May;23(5):3118-3129
Journal of cellular and molecular medicine 2019 May;23(5):3118-3129
MicroRNA‑1 downregulation induced by carvedilol protects cardiomyocytes against apoptosis by targeting heat shock protein 60.
Hu Y, Chen X, Li X, Li Z, Diao H, Liu L, Zhang J, Ju J, Wen L, Liu X, Pan Z, Xu C, Hai X, Zhang Y
Molecular medicine reports 2019 May;19(5):3527-3536
Molecular medicine reports 2019 May;19(5):3527-3536
Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.
Chen FF, Song FQ, Chen YQ, Wang ZH, Li YH, Liu MH, Li Y, Song M, Zhang W, Zhao J, Zhong M
Experimental gerontology 2019 May;119:128-137
Experimental gerontology 2019 May;119:128-137
Alkaloids from Piper nigrum Synergistically Enhanced the Effect of Paclitaxel against Paclitaxel-Resistant Cervical Cancer Cells through the Downregulation of Mcl-1.
Xie Z, Wei Y, Xu J, Lei J, Yu J
Journal of agricultural and food chemistry 2019 May 8;67(18):5159-5168
Journal of agricultural and food chemistry 2019 May 8;67(18):5159-5168
Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.
Kasamatsu A, Uzawa K, Hayashi F, Kita A, Okubo Y, Saito T, Kimura Y, Miyamoto I, Oka N, Shiiba M, Ito C, Toshimori K, Miki T, Yamauchi M, Tanzawa H
Biochemical and biophysical research communications 2019 May 7;512(3):486-491
Biochemical and biophysical research communications 2019 May 7;512(3):486-491
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Yang F, Lin ZW, Huang TY, Chen TT, Cui J, Li MY, Hua YQ
Scientific reports 2019 May 6;9(1):6991
Scientific reports 2019 May 6;9(1):6991
Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis.
Sabir N, Hussain T, Liao Y, Wang J, Song Y, Shahid M, Cheng G, Mangi MH, Yao J, Yang L, Zhao D, Zhou X
Cells 2019 May 5;8(5)
Cells 2019 May 5;8(5)
USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Myc and SOD2.
Liu Q, Sheng W, Ma Y, Zhen J, Roy S, Alvira Jafar C, Xin W, Wan Q
Biochemical and biophysical research communications 2019 May 28;513(2):502-508
Biochemical and biophysical research communications 2019 May 28;513(2):502-508
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Chen C, Jiang L, Zhang M, Pan X, Peng C, Huang W, Jiang Q
Food & function 2019 May 22;10(5):2651-2657
Food & function 2019 May 22;10(5):2651-2657
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Yu Z, Jv Y, Cai L, Tian X, Huo X, Wang C, Zhang B, Sun C, Ning J, Feng L, Zhang H, Ma X
Toxicology and applied pharmacology 2019 May 15;371:63-73
Toxicology and applied pharmacology 2019 May 15;371:63-73
Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury.
Gong W, Song J, Chen X, Li S, Yu J, Xia W, Ding G, Zhang Y, Jia Z, Zhang A, Huang S
American journal of physiology. Renal physiology 2019 May 1;316(5):F906-F913
American journal of physiology. Renal physiology 2019 May 1;316(5):F906-F913
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax.
Yang D, Zhang L, Zhang Z, Hu S, Fu Y, Laukkanen JA, Li G
Clinical and experimental pharmacology & physiology 2019 Mar;46(3):237-245
Clinical and experimental pharmacology & physiology 2019 Mar;46(3):237-245
Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.
Li J, Cai H, Li H, Liu Y, Wang Y, Shi Y, Sun Y, Song H, Wang D
Oncology reports 2019 Mar;41(3):1991-1997
Oncology reports 2019 Mar;41(3):1991-1997
Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
Zhang X, Yang X, Zhu S, Li Q, Zou N
Oncology reports 2019 Mar;41(3):1960-1970
Oncology reports 2019 Mar;41(3):1960-1970
XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.
Teng X, Fan XF, Li Q, Liu S, Wu DY, Wang SY, Shi Y, Dong M
Oncology reports 2019 Mar;41(3):1875-1882
Oncology reports 2019 Mar;41(3):1875-1882
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Li C, Wang Y, Li L, Han Z, Mao S, Wang G
Cell stress & chaperones 2019 Mar;24(2):453-460
Cell stress & chaperones 2019 Mar;24(2):453-460
Toxicity Effects of Methylene Blue on Rat Intervertebral Disc Annulus Fibrosus Cells.
Zhang L, Liu Y, Huang Z, Nan L, Wang F, Zhou S, Wang J, Feng X
Pain physician 2019 Mar;22(2):155-164
Pain physician 2019 Mar;22(2):155-164
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Shah SZA, Zhao D, Taglialatela G, Hussain T, Dong H, Sabir N, Mangi MH, Wu W, Lai M, Zhang X, Duan Y, Wang L, Zhou X, Yang L
International journal of molecular sciences 2019 Mar 6;20(5)
International journal of molecular sciences 2019 Mar 6;20(5)
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer.
Liu C, Shi J, Li Q, Li Z, Lou C, Zhao Q, Zhu Y, Zhan F, Lian J, Wang B, Guan X, Fang L, Li Z, Wang Y, Zhou B, Yao Y, Zhang Y
Clinical science (London, England : 1979) 2019 Mar 15;133(5):645-663
Clinical science (London, England : 1979) 2019 Mar 15;133(5):645-663
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
Li YM, Zhang J, Su LJ, Kellum JA, Peng ZY
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
The attenuation of HIV-1 Tat-induced neurotoxicity by Salvianic acid A and Danshen granule.
Bao D, Wang J, Liu J, Qin T, Liu H
International journal of biological macromolecules 2019 Mar 1;124:863-870
International journal of biological macromolecules 2019 Mar 1;124:863-870
Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways.
Wang R, Wang J, Ding N, He S, Zhao Y, Gao P
Translational cancer research 2019 Jun;8(3):968-975
Translational cancer research 2019 Jun;8(3):968-975
Acid sphingomyelinase mediates the noise-induced liver disorder in mice.
Meng X, Gu Z, Xie X, Su Y, Zhang X, Ma H, Guo Y, Liu X, Cheng Y, Chang Y, Bao J
Clinical and experimental pharmacology & physiology 2019 Jun;46(6):556-566
Clinical and experimental pharmacology & physiology 2019 Jun;46(6):556-566
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
Liu R, Xu X, Liang C, Chen X, Yu X, Zhong H, Xu W, Cheng Y, Wang W, Wu Y, Yu L, Hu X
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload.
Dijiong W, Xiaowen W, Linlong X, Wenbin L, Huijin H, Baodong Y, Yuhong Z
Iranian journal of basic medical sciences 2019 Jun;22(6):660-668
Iranian journal of basic medical sciences 2019 Jun;22(6):660-668
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Wan GX, Cheng L, Qin HL, Zhang YZ, Wang LY, Zhang YG
Cardiovascular toxicology 2019 Jun;19(3):264-275
Cardiovascular toxicology 2019 Jun;19(3):264-275
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Liu F, Knight T, Su Y, Edwards H, Wang G, Wang Y, Taub JW, Lin H, Sun L, Ge Y
Targeted oncology 2019 Jun;14(3):351-364
Targeted oncology 2019 Jun;14(3):351-364
Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.
Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, Li Y
Physiological research 2019 Jun 30;68(3):445-455
Physiological research 2019 Jun 30;68(3):445-455
TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat.
Zhang J, Yao D, Zhang J, Song Y, Mo F, Chu X, Pan Y, Bai Y, Shao C
Biochemical and biophysical research communications 2019 Jun 30;514(3):678-683
Biochemical and biophysical research communications 2019 Jun 30;514(3):678-683
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats.
Agbo E, Liu D, Li M, Saahene RO, Chen L, Zhao L, Wang Y, Tian G
Turkish journal of medical sciences 2019 Jun 18;49(3):945-958
Turkish journal of medical sciences 2019 Jun 18;49(3):945-958
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
Wang R, Li D, Ouyang J, Tian X, Zhao Y, Peng X, Li S, Yu G, Yang J
Toxicology 2019 Jun 15;422:1-13
Toxicology 2019 Jun 15;422:1-13
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
Dong S, Ji J, Hu L, Wang H
Life sciences 2019 Jun 15;227:20-29
Life sciences 2019 Jun 15;227:20-29
2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.
Li ED, Lin Q, Meng YQ, Zhang LY, Song PP, Li N, Xin JC, Yang P, Bao CN, Zhang DQ, Zhang Y, Wang JK, Zhang QR, Liu HM
European journal of medicinal chemistry 2019 Jun 15;172:36-47
European journal of medicinal chemistry 2019 Jun 15;172:36-47
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
Hua L, Wu N, Zhao R, He X, Liu Q, Li X, He Z, Yu L, Yan N
International journal of molecular sciences 2019 Jun 12;20(12)
International journal of molecular sciences 2019 Jun 12;20(12)
Role of TMPRSS4 Modulation in Breast Cancer Cell Proliferation.
Assani G, Yessoufou A, Xiong Y, Segbo J, Yu X, Zhou F, Zhou Y
Asian Pacific journal of cancer prevention : APJCP 2019 Jun 1;20(6):1849-1856
Asian Pacific journal of cancer prevention : APJCP 2019 Jun 1;20(6):1849-1856
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Lu GQ, Li XY, Mohamed O K, Wang D, Meng FH
European journal of medicinal chemistry 2019 Jun 1;171:282-296
European journal of medicinal chemistry 2019 Jun 1;171:282-296
Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
Guo Z, Xu J, Xia J, Wu Z, Lei J, Yu J
The Journal of pharmacy and pharmacology 2019 Jul;71(7):1162-1171
The Journal of pharmacy and pharmacology 2019 Jul;71(7):1162-1171
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, Jiang R, Guo M, Han D, Liu B, Wang N, Li Y, Huang H, Zeng L, Gao Y, Li X, Wu Y
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Echinacoside Alleviates Hypoxic-Ischemic Brain Injury in Neonatal Rat by Enhancing Antioxidant Capacity and Inhibiting Apoptosis.
Wei W, Lan XB, Liu N, Yang JM, Du J, Ma L, Zhang WJ, Niu JG, Sun T, Yu JQ
Neurochemical research 2019 Jul;44(7):1582-1592
Neurochemical research 2019 Jul;44(7):1582-1592
p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro.
He GQ, Liu GY, Xu WM, Liao HJ, Liu XH, He GL
International journal of molecular medicine 2019 Jul;44(1):281-290
International journal of molecular medicine 2019 Jul;44(1):281-290
Amentoflavone Induces Apoptosis and Reduces Expression of Anti-apoptotic and Metastasis-associated Proteins in Bladder Cancer.
Chiang CH, Yeh CY, Chung JG, Chiang IT, Hsu FT
Anticancer research 2019 Jul;39(7):3641-3649
Anticancer research 2019 Jul;39(7):3641-3649
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Chen L, Liu L, Xie ZY, Wang F, Zhu L, Zhang C, Fan P, Sinkemani A, Hong X, Wu XT
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
Tian L, Su CP, Wang Q, Wu FJ, Bai R, Zhang HM, Liu JY, Lu WJ, Wang W, Lan F, Guo SZ
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678
HBOA ameliorates CCl(4)-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Sun X, Huang X, Zhu X, Liu L, Mo S, Wang H, Wei X, Lu S, Bai F, Wang D, Lin X, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis.
Chen DB, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Cong X, Fei R, Wu X, Shao QX, Wei L, Xie XW, Chen HS
Chinese medical journal 2019 Jul 5;132(13):1572-1581
Chinese medical journal 2019 Jul 5;132(13):1572-1581
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway.
Yin F, Yan J, Zhao Y, Guo KJ, Zhang ZL, Li AP, Meng CY, Guo L
Ecotoxicology and environmental safety 2019 Jul 30;176:234-241
Ecotoxicology and environmental safety 2019 Jul 30;176:234-241
Melatonin attenuates cadmium-induced ovulatory dysfunction by suppressing endoplasmic reticulum stress and cell apoptosis.
Yang Q, Zhu J, Luo X, Li F, Cong L, Wang Y, Sun Y
Reproductive biology and endocrinology : RB&E 2019 Jul 29;17(1):61
Reproductive biology and endocrinology : RB&E 2019 Jul 29;17(1):61
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Dong Q, Yang B, Han JG, Zhang MM, Liu W, Zhang X, Yu HL, Liu ZG, Zhang SH, Li T, Wu DD, Ji XY, Duan SF
Cancer letters 2019 Jul 28;455:60-72
Cancer letters 2019 Jul 28;455:60-72
Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients.
Li J, Yang G, Liu S, Wang L, Liang Z, Zhang H
Clinical epigenetics 2019 Jul 23;11(1):107
Clinical epigenetics 2019 Jul 23;11(1):107
Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma.
Deng L, Sun J, Chen X, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2019 Jul 18;38(1):316
Journal of experimental & clinical cancer research : CR 2019 Jul 18;38(1):316
In vivo tracking on longer retention of transplanted myocardin gene-modified adipose-derived stem cells to improve erectile dysfunction in diabetic rats.
Zhang HB, Chen FZ, He SH, Liang YB, Wang ZQ, Wang L, Chen ZR, Ding W, Zhao SC, Wei AY
Stem cell research & therapy 2019 Jul 16;10(1):208
Stem cell research & therapy 2019 Jul 16;10(1):208
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Zierhut C, Yamaguchi N, Paredes M, Luo JD, Carroll T, Funabiki H
Cell 2019 Jul 11;178(2):302-315.e23
Cell 2019 Jul 11;178(2):302-315.e23
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Li XY, Zhang TJ, Kamara MO, Lu GQ, Xu HL, Wang DP, Meng FH
Cell death & disease 2019 Jul 11;10(7):532
Cell death & disease 2019 Jul 11;10(7):532
Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.
Wen ZP, Zeng WJ, Chen YH, Li H, Wang JY, Cheng Q, Yu J, Zhou HH, Liu ZZ, Xiao J, Chen XP
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):298
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):298
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK.
Wang Y, Wang X, Zhou X, Zhu Z, Yang J, Liu F
International journal of molecular medicine 2019 Jan;43(1):177-184
International journal of molecular medicine 2019 Jan;43(1):177-184
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload.
Chen C, Zou LX, Lin QY, Yan X, Bi HL, Xie X, Wang S, Wang QS, Zhang YL, Li HH
Redox biology 2019 Jan;20:390-401
Redox biology 2019 Jan;20:390-401
Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.
Yao X, Zhang J, Jing X, Ye Y, Guo J, Sun K, Guo F
Pharmacological research 2019 Jan;139:314-324
Pharmacological research 2019 Jan;139:314-324
Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism.
Ling L, Feng X, Wei T, Wang Y, Wang Y, Wang Z, Tang D, Luo Y, Xiong Z
Stem cell research & therapy 2019 Jan 25;10(1):46
Stem cell research & therapy 2019 Jan 25;10(1):46
Selective Serotonin Reuptake Inhibitors Aggravate Depression-Associated Dry Eye Via Activating the NF-κB Pathway.
Zhang X, Yin Y, Yue L, Gong L
Investigative ophthalmology & visual science 2019 Jan 2;60(1):407-419
Investigative ophthalmology & visual science 2019 Jan 2;60(1):407-419
Anti-breast Cancer Activity of SPG-56 from Sweet Potato in MCF-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis.
Li Z, Yu Y, Wang M, Xu H, Han B, Jiang P, Ma H, Li Y, Tian C, Zhou D, Li X, Ye X
Scientific reports 2019 Jan 16;9(1):146
Scientific reports 2019 Jan 16;9(1):146
Autophagy and Apoptosis Interact to Modulate T-2 Toxin-Induced Toxicity in Liver Cells.
Wu J, Zhou Y, Yuan Z, Yi J, Chen J, Wang N, Tian Y
Toxins 2019 Jan 15;11(1)
Toxins 2019 Jan 15;11(1)
Role of ZIP8 in regulation of cisplatin sensitivity through Bcl-2.
Geng X, Liu L, Tsai KJ, Liu Z
Toxicology and applied pharmacology 2019 Jan 1;362:52-58
Toxicology and applied pharmacology 2019 Jan 1;362:52-58
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Xu B, Zang SC, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Brain, behavior, and immunity 2019 Feb;76:223-235
Brain, behavior, and immunity 2019 Feb;76:223-235
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Jin HZ, Fang YY, Jin QG, Fang N
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT/NF-κB signaling pathway.
Ahmmed B, Khan MN, Nisar MA, Kampo S, Zheng Q, Li Y, Yan Q
International journal of oncology 2019 Feb;54(2):431-442
International journal of oncology 2019 Feb;54(2):431-442
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Zhao B, Hu T
Oncology letters 2019 Feb;17(2):1939-1945
Oncology letters 2019 Feb;17(2):1939-1945
Ebselen protects rat hearts against myocardial ischemia-reperfusion injury.
Cheng B, Zhong JP, Wu FX, Li GL, Ruan QX, Luo G, Jiang H
Experimental and therapeutic medicine 2019 Feb;17(2):1412-1419
Experimental and therapeutic medicine 2019 Feb;17(2):1412-1419
Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates.
Chen Z, Wang C, Li TF, Li K, Yue Y, Liu X, Xu HZ, Wen Y, Zhang Q, Han M, Komatsu N, Xu YH, Zhao L, Chen X
Nanomedicine (London, England) 2019 Feb;14(3):335-351
Nanomedicine (London, England) 2019 Feb;14(3):335-351
Exogenous Tetranectin Protects Against 1-Methyl-4-Phenylpyridine-Induced Neurotoxicity by Inhibiting Apoptosis and Autophagy Through Ribosomal Protein S6 Kinase Beta-1.
Xie Q, Liu M, Yan YF, Shen X, Wang ES
World neurosurgery 2019 Feb;122:e375-e382
World neurosurgery 2019 Feb;122:e375-e382
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Shah SZA, Fang N
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA.
Xie Z, Guo Z, Lei J, Yu J
European journal of pharmacology 2019 Feb 5;844:9-16
European journal of pharmacology 2019 Feb 5;844:9-16
Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.
Zhao Y, Wang Q, Zang B
Acta cirurgica brasileira 2019 Feb 28;34(2):e201900209
Acta cirurgica brasileira 2019 Feb 28;34(2):e201900209
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
Li L, Liu M, Zhang Z, Zhang W, Liu N, Sheng X, Wei P
Biological research 2019 Feb 27;52(1):8
Biological research 2019 Feb 27;52(1):8
MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.
Xu K, Han B, Bai Y, Ma XY, Ji ZN, Xiong Y, Miao SK, Zhang YY, Zhou LM
Cell death & disease 2019 Feb 15;10(3):152
Cell death & disease 2019 Feb 15;10(3):152
κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.
Cui Y, Feng N, Gu X, Fu F, Li J, Guo H, Liu Y, Zhang S, Li J, Wang Y, Jia M, Yang L, Zhang F, Wang Y, Fan R, Pei J
Lipids in health and disease 2019 Feb 14;18(1):52
Lipids in health and disease 2019 Feb 14;18(1):52
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Protective Effect of Koumine, an Alkaloid from Gelsemium Sempervirens, on Injury Induced by H₂O₂ in IPEC-J2 Cells.
Yuan Z, Liang Z, Yi J, Chen X, Li R, Wu Y, Wu J, Sun Z
International journal of molecular sciences 2019 Feb 11;20(3)
International journal of molecular sciences 2019 Feb 11;20(3)
Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats.
Lian S, Xu B, Wang D, Wang L, Li W, Yao R, Ji H, Wang J, Guo J, Li S, Yang H
Behavioural brain research 2019 Feb 1;359:304-311
Behavioural brain research 2019 Feb 1;359:304-311
Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice.
Ren Z, Chen L, Wang Y, Wei X, Zeng S, Zheng Y, Gao C, Liu H
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 1;202(3):747-759
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 1;202(3):747-759
Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol In Vitro and In Vivo.
Zhang D, Zhang J, Zeng J, Li Z, Zuo H, Huang C, Zhao X
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Journal of biomedical nanotechnology 2019 Feb 1;15(2):288-300
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Guo J, Tang Q, Wang Q, Sun W, Pu Z, Wang J, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
Silence of S1 RNA binding domain 1 represses cell growth and promotes apoptosis in human non-small cell lung cancer cells.
Zhang T, Cheng G, Deng L, Yang Y, Sun L, Chen P, He X, Su D, Bi N, Qiu B
Translational lung cancer research 2019 Dec;8(6):760-774
Translational lung cancer research 2019 Dec;8(6):760-774
Protective effect of miR-20a against hypoxia/reoxygenation treatment on cardiomyocytes cell viability and cell apoptosis by targeting TLR4 and inhibiting p38 MAPK/JNK signaling.
Gong XY, Zhang Y
In vitro cellular & developmental biology. Animal 2019 Dec;55(10):793-800
In vitro cellular & developmental biology. Animal 2019 Dec;55(10):793-800
Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway.
Nan F, Sun G, Xie W, Ye T, Sun X, Zhou P, Dong X, Sun J, Sun X, Zhang M
Molecular and cellular probes 2019 Dec;48:101469
Molecular and cellular probes 2019 Dec;48:101469
Anti-tumour effects of red blood cell membrane-camouflaged black phosphorous quantum dots combined with chemotherapy and anti-inflammatory therapy.
Huang X, Wu B, Li J, Shang Y, Chen W, Nie X, Gui R
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):968-979
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):968-979
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Li T, Xiong Y, Wang Q, Chen F, Zeng Y, Yu X, Wang Y, Zhou F, Zhou Y
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Molecular mechanism of miR-204 regulates proliferation, apoptosis and autophagy of cervical cancer cells by targeting ATF2.
Li N, Guo X, Liu L, Wang L, Cheng R
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):2529-2535
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):2529-2535
Notch1 Drives the Formation and Proliferation of Intrahepatic Cholangiocarcinoma.
Guo J, Fu W, Xiang M, Zhang Y, Zhou K, Xu CR, Li L, Kuang D, Ye F
Current medical science 2019 Dec;39(6):929-937
Current medical science 2019 Dec;39(6):929-937
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Inhibition of cyclin-dependent kinase 5 activity alleviates diabetes-related cognitive deficits.
Liu W, Zhou Y, Liang R, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):14506-14515
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):14506-14515
Transarterial Infusion of iRGD-Modified ZrO(2) Nanoparticles with Lipiodol Improves the Tissue Distribution of Doxorubicin and Its Antitumor Efficacy.
Xie Y, Qi X, Xu K, Meng X, Chen X, Wang F, Zhong H
Journal of vascular and interventional radiology : JVIR 2019 Dec;30(12):2026-2035.e2
Journal of vascular and interventional radiology : JVIR 2019 Dec;30(12):2026-2035.e2
Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway.
Ma S, Liu T, Xu L, Wang Y, Zhou J, Huang T, Li P, Liu H, Zhang Y, Zhou X, Cui Y, Zang X, Wang Y, Guan F
Journal of cellular physiology 2019 Dec;234(12):22400-22410
Journal of cellular physiology 2019 Dec;234(12):22400-22410
Effects of kojic acid on boar sperm quality and anti-bacterial activity during liquid preservation at 17 C.
Shaoyong W, Li Q, Ren Z, Xiao J, Diao Z, Yang G, Pang W
Theriogenology 2019 Dec;140:124-135
Theriogenology 2019 Dec;140:124-135
Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro.
Lin L, Yuan F, Liu Y, Zhong M, Xie T, Ni J, Li H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109531
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109531
miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.
Xu F, Yan JJ, Gan Y, Chang Y, Wang HL, He XX, Zhao Q
Molecular therapy. Nucleic acids 2019 Dec 6;18:308-319
Molecular therapy. Nucleic acids 2019 Dec 6;18:308-319
Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy.
Han L, Dai S, Li Z, Zhang C, Wei S, Zhao R, Zhang H, Zhao L, Shan B
Journal of experimental & clinical cancer research : CR 2019 Dec 21;38(1):501
Journal of experimental & clinical cancer research : CR 2019 Dec 21;38(1):501
The long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5.
Yang D, Yu J, Liu HB, Yan XQ, Hu J, Yu Y, Guo J, Yuan Y, Du ZM
Cell death & disease 2019 Dec 2;10(12):908
Cell death & disease 2019 Dec 2;10(12):908
Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.
Xu S, Zhan M, Jiang C, He M, Yang L, Shen H, Huang S, Huang X, Lin R, Shi Y, Liu Q, Chen W, Mohan M, Wang J
Nature communications 2019 Dec 2;10(1):5492
Nature communications 2019 Dec 2;10(1):5492
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head.
Yin Y, Ding L, Hou Y, Jiang H, Zhang J, Dai Z, Zhang G
Nanoscale research letters 2019 Dec 18;14(1):383
Nanoscale research letters 2019 Dec 18;14(1):383
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression.
Cao M, Zhu B, Sun Y, Zhao X, Qiu G, Fu W, Jiang H
Life sciences 2019 Dec 15;239:117040
Life sciences 2019 Dec 15;239:117040
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Liu L, Chen H, Jin J, Tang Z, Yin P, Zhong D, Li G
Life sciences 2019 Dec 15;239:117036
Life sciences 2019 Dec 15;239:117036
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
Guo X, Shi Y, Du P, Wang J, Han Y, Sun B, Feng J
Life sciences 2019 Dec 15;239:117020
Life sciences 2019 Dec 15;239:117020
Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent.
He Z, Qiao H, Yang F, Zhou W, Gong Y, Zhang X, Wang H, Zhao B, Ma L, Liu HM, Zhao W
European journal of medicinal chemistry 2019 Dec 15;184:111764
European journal of medicinal chemistry 2019 Dec 15;184:111764
PRMT4 overexpression aggravates cardiac remodeling following myocardial infarction by promoting cardiomyocyte apoptosis.
Wang Y, Ju C, Hu J, Huang K, Yang L
Biochemical and biophysical research communications 2019 Dec 10;520(3):645-650
Biochemical and biophysical research communications 2019 Dec 10;520(3):645-650
Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, Lin D, Yang K
Experimental cell research 2019 Dec 1;385(1):111669
Experimental cell research 2019 Dec 1;385(1):111669
Downregulation of TMPRSS4 Enhances Triple-Negative Breast Cancer Cell Radiosensitivity Through Cell Cycle and Cell Apoptosis Process Impairment.
Assani G, Segbo J, Yu X, Yessoufou A, Xiong Y, Zhou F, Zhou Y
Asian Pacific journal of cancer prevention : APJCP 2019 Dec 1;20(12):3679-3687
Asian Pacific journal of cancer prevention : APJCP 2019 Dec 1;20(12):3679-3687
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578
International journal of food sciences and nutrition 2019 Aug;70(5):570-578
Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis.
Yang CH, Xu JH, Ren QC, Duan T, Mo F, Zhang W
Journal of pineal research 2019 Aug;67(1):e12569
Journal of pineal research 2019 Aug;67(1):e12569
Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect.
Zhang K, Zhou Y, Xiao C, Zhao W, Wu H, Tang J, Li Z, Yu S, Li X, Min L, Yu Z, Wang G, Wang L, Zhang K, Yang X, Zhu X, Tu C, Zhang X
Science advances 2019 Aug;5(8):eaax6946
Science advances 2019 Aug;5(8):eaax6946
Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF.
Liu X, Ma W, Ma J, Xiao L, Hao D
Pathology, research and practice 2019 Aug;215(8):152492
Pathology, research and practice 2019 Aug;215(8):152492
RING finger protein 10 is a potential drug target for diabetic vascular complications.
Li S, Yu G, Huang W, Wang R, Pu P, Chen M
Molecular medicine reports 2019 Aug;20(2):931-938
Molecular medicine reports 2019 Aug;20(2):931-938
E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1.
Li X, Zhang N, Zhang Y, Jia P, Guo Y, Tian Y, You S, Wu S, Sun Y
Molecular medicine reports 2019 Aug;20(2):1561-1568
Molecular medicine reports 2019 Aug;20(2):1561-1568
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.
Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Aug;1862(8):846-857
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Aug;1862(8):846-857
Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression.
Yu Y, Liu H, Yang D, He F, Yuan Y, Guo J, Hu J, Yu J, Yan X, Wang S, Du Z
Pharmacological research 2019 Aug;146:104315
Pharmacological research 2019 Aug;146:104315
Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.
Wen J, Xu B, Sun Y, Lian M, Li Y, Lin Y, Chen D, Diao Y, Almoiliqy M, Wang L
Pharmacological research 2019 Aug;146:104308
Pharmacological research 2019 Aug;146:104308
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Li T, Zha L, Luo H, Li S, Zhao L, He J, Li X, Qi Q, Liu Y, Yu Z
Aging and disease 2019 Aug;10(4):731-745
Aging and disease 2019 Aug;10(4):731-745
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
Shang Y, Wang Q, Wu B, Zhao Q, Li J, Huang X, Chen W, Gui R
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
[Effect of the chemoprotectant tempol on anti-tumor activity of cisplatin].
Ye S, Zeng S, Huang M, Chen J, Chen X, Xu P, Wang Q, Gao W, Yang B, Hao B, Huang W, Liu Q
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Aug 30;39(8):883-890
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Aug 30;39(8):883-890
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
Liu NW, Huang X, Liu S, Lu Y
Medical science monitor : international medical journal of experimental and clinical research 2019 Aug 29;25:6491-6503
Medical science monitor : international medical journal of experimental and clinical research 2019 Aug 29;25:6491-6503
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Wang Y, Yang C, Elsheikh NAH, Li C, Yang F, Wang G, Li L
Aging 2019 Aug 12;11(15):5535-5547
Aging 2019 Aug 12;11(15):5535-5547
LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Jin J, Sun H, Liu D, Wang H, Liu Q, Chen H, Zhong D, Li G
Neuroscience 2019 Aug 10;413:123-134
Neuroscience 2019 Aug 10;413:123-134
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
Silencing of Astrocyte elevated gene-1 (AEG-1) inhibits proliferation, migration, and invasiveness, and promotes apoptosis in pancreatic cancer cells.
Yang X, Song S
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):165-175
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Apr;97(2):165-175
SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway.
Nie X, Guo E, Wu C, Liu D, Sun W, Zhang L, Long G, Mei Q, Wu K, Xiong H, Hu G
Cancer medicine 2019 Apr;8(4):1779-1792
Cancer medicine 2019 Apr;8(4):1779-1792
Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle and apoptosis in mouse spermatogenic cells.
Li H, Dai Y, Luo Z, Nie D
Molecular biology reports 2019 Apr;46(2):2029-2038
Molecular biology reports 2019 Apr;46(2):2029-2038
Protective effects of ethyl gallate on H(2)O(2)-induced mitochondrial dysfunction in PC12 cells.
Chen L, Wu X, Shen T, Wang X, Wang S, Wang J, Ren D
Metabolic brain disease 2019 Apr;34(2):545-555
Metabolic brain disease 2019 Apr;34(2):545-555
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Jing Z, Wang C, Yang Q, Wei X, Jin Y, Meng Q, Liu Q, Liu Z, Ma X, Liu K, Sun H, Liu M
Journal of cellular physiology 2019 Apr;234(4):4472-4490
Journal of cellular physiology 2019 Apr;234(4):4472-4490
Heme oxygenase 1 regulates apoptosis induced by heat stress in bovine ovarian granulosa cells via the ERK1/2 pathway.
Wang YR, Chen KL, Li CM, Li L, Wang GL
Journal of cellular physiology 2019 Apr;234(4):3961-3972
Journal of cellular physiology 2019 Apr;234(4):3961-3972
Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.
Zhu F, Yan P, Zhang J, Cui Y, Zheng M, Cheng Y, Guo Y, Yang X, Guo X, Zhu H
Journal of cellular and molecular medicine 2019 Apr;23(4):2583-2594
Journal of cellular and molecular medicine 2019 Apr;23(4):2583-2594
Treatment with metformin prevents myocardial ischemia-reperfusion injury via STEAP4 signaling pathway.
Luo T, Zeng X, Yang W, Zhang Y
Anatolian journal of cardiology 2019 Apr;21(5):261-271
Anatolian journal of cardiology 2019 Apr;21(5):261-271
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Li XG, Du JH, Lu Y, Lin XJ
Neural regeneration research 2019 Apr;14(4):721-727
Neural regeneration research 2019 Apr;14(4):721-727
Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
Sulaiman D, Li J, Devarajan A, Cunningham CM, Li M, Fishbein GA, Fogelman AM, Eghbali M, Reddy ST
Journal of molecular and cellular cardiology 2019 Apr;129:154-164
Journal of molecular and cellular cardiology 2019 Apr;129:154-164
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.
Lu L, Chen G, Yang J, Ma Z, Yang Y, Hu Y, Lu Y, Cao Z, Wang Y, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108625
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108625
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
Xiong Y, Li T, Assani G, Ling H, Zhou Q, Zeng Y, Zhou F, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway.
Zhang Y, Sun C, Xiao G, Gu Y
Biochemical and biophysical research communications 2019 Apr 30;512(2):269-275
Biochemical and biophysical research communications 2019 Apr 30;512(2):269-275
Activation of the MAPK signaling pathway induces upregulation of pro-apoptotic proteins in the hippocampi of cold stressed adolescent mice.
Xu B, Lian S, Guo JR, Wang JF, Zhang LP, Li SZ, Yang HM
Neuroscience letters 2019 Apr 23;699:97-102
Neuroscience letters 2019 Apr 23;699:97-102
Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism.
Li H, Ruan WJ, Liu LQ, Wan HF, Yang XH, Zhu WF, Yu LH, Zhang XL, Wan FS
Chinese medical journal 2019 Apr 20;132(8):948-956
Chinese medical journal 2019 Apr 20;132(8):948-956
Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells.
Hong Y, Fan D
Toxicology 2019 Apr 15;418:22-31
Toxicology 2019 Apr 15;418:22-31
Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.
Xu Z, Zhang Y, Zhang S, Jia X, Zhong G, Yang Y, Du Q, Li J, Liu Z
Cancer letters 2019 Apr 10;447:75-85
Cancer letters 2019 Apr 10;447:75-85
Effects of 220 MHz Pulsed Modulated Radiofrequency Field on the Sperm Quality in Rats.
Guo L, Lin JJ, Xue YZ, An GZ, Zhang JP, Zhang KY, He W, Wang H, Li W, Ding GR
International journal of environmental research and public health 2019 Apr 10;16(7)
International journal of environmental research and public health 2019 Apr 10;16(7)
Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells.
Wang S, Ren X, Hu X, Zhou L, Zhang C, Zhang M
Toxicology and applied pharmacology 2019 Apr 1;368:37-48
Toxicology and applied pharmacology 2019 Apr 1;368:37-48
Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure.
Zhao Y, Li Y, Tong L, Liang X, Zhang H, Li L, Fan G, Wang Y
Frontiers in physiology 2018;9:48
Frontiers in physiology 2018;9:48
β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
Cao ZQ, Wang XX, Lu L, Xu JW, Li XB, Zhang GR, Ma ZJ, Shi AC, Wang Y, Song YJ
Frontiers in pharmacology 2018;9:1525
Frontiers in pharmacology 2018;9:1525
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Mao J, Yi M, Wang R, Huang Y, Chen M
Frontiers in pharmacology 2018;9:1469
Frontiers in pharmacology 2018;9:1469
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study.
Pan B, Zang J, He J, Wang Z, Liu L
American journal of cancer research 2018;8(6):1090-1105
American journal of cancer research 2018;8(6):1090-1105
Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells.
Liu W, Meng Q, Sun Y, Wang C, Huo X, Liu Z, Sun P, Sun H, Ma X, Liu K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(4):1616-1631
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(4):1616-1631
Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3.
He F, Liu H, Guo J, Yang D, Yu Y, Yu J, Yan X, Hu J, Du Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):186-200
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):186-200
High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway.
Wang Y, Tang H, He G, Shi Y, Kang X, Lyu J, Zhou M, Zhu M, Zhang J, Tang K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2046-2059
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2046-2059
CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8.
Liu J, Wang D, Long Z, Liu J, Li W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(1):173-184
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(1):173-184
Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.
Zheng Q, Zhou F, Cui X, Liu M, Li Y, Liu S, Tan J, Yan Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2297-2310
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2297-2310
Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway.
Chen Y, Chang Y, Zhang N, Guo X, Sun G, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(3):1009-1018
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(3):1009-1018
MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress.
Xu Y, Sun D, Song C, Wang R, Dong X
The Journal of toxicological sciences 2018;43(9):545-555
The Journal of toxicological sciences 2018;43(9):545-555
MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Tian ZQ, Jiang H, Lu ZB
Cellular & molecular biology letters 2018;23:41
Cellular & molecular biology letters 2018;23:41
Transcription factor KLF13 inhibits AKT activation and suppresses the growth of prostate carcinoma cells.
Wang Q, Peng R, Wang B, Wang J, Yu W, Liu Y, Shi G
Cancer biomarkers : section A of Disease markers 2018;22(3):533-541
Cancer biomarkers : section A of Disease markers 2018;22(3):533-541
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Zhang GY, Lu D, Duan SF, Gao YR, Liu SY, Hong Y, Dong PZ, Chen YG, Li T, Wang DY, Cheng XS, He F, Wei JS, Li GY, Zhang QY, Wu DD, Ji XY
Oxidative medicine and cellular longevity 2018;2018:9647809
Oxidative medicine and cellular longevity 2018;2018:9647809
Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ.
Kong R, Luo H, Wang N, Li J, Xu S, Chen K, Feng J, Wu L, Li S, Liu T, Lu X, Xia Y, Shi Y, Zhou Y, He W, Dai Q, Zheng Y, Lu J
PPAR research 2018;2018:6079101
PPAR research 2018;2018:6079101
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Yu Q, Liu T, Li S, Feng J, Wu L, Wang W, Chen K, Xia Y, Niu P, Xu L, Wang F, Dai W, Zhou Y, Guo C
Mediators of inflammation 2018;2018:4032484
Mediators of inflammation 2018;2018:4032484
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T
Oxidative medicine and cellular longevity 2018;2018:3853409
Oxidative medicine and cellular longevity 2018;2018:3853409
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
Bai YD, Yang YR, Mu XP, Lin G, Wang YP, Jin S, Chen Y, Wang MJ, Zhu YC
Oxidative medicine and cellular longevity 2018;2018:3402809
Oxidative medicine and cellular longevity 2018;2018:3402809
The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.
Wang W, Chen K, Xia Y, Mo W, Wang F, Dai W, Niu P
PPAR research 2018;2018:3180396
PPAR research 2018;2018:3180396
Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.
Mo W, Wang C, Li J, Chen K, Xia Y, Li S, Xu L, Lu X, Wang W, Guo C
Gastroenterology research and practice 2018;2018:2824139
Gastroenterology research and practice 2018;2018:2824139
Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells.
He Y, Khan M, Yang J, Yao M, Yu S, Gao H
International journal of medical sciences 2018;15(8):832-839
International journal of medical sciences 2018;15(8):832-839
SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.
Cui X, Zhao C, Yao X, Qian B, Su C, Ren Y, Yao Z, Gao X, Yang J
RNA biology 2018;15(10):1364-1375
RNA biology 2018;15(10):1364-1375
Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction.
Yin S, Zhang L, Ding L, Huang Z, Xu B, Li X, Wang P, Mao J
Journal of inflammation (London, England) 2018;15:27
Journal of inflammation (London, England) 2018;15:27
Erythropoietin attenuates motor neuron programmed cell death in a burn animal model.
Wu SH, Lu IC, Lee SS, Kwan AL, Chai CY, Huang SH
PloS one 2018;13(1):e0190039
PloS one 2018;13(1):e0190039
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Ding W, Ji T, Xiong W, Li T, Pu D, Liu R
Drug design, development and therapy 2018;12:3459-3469
Drug design, development and therapy 2018;12:3459-3469
Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis.
Yang L, Han W, Luo Y, Hu X, Xu Y, Li H, Hu C, Huang D, Ma J, Yang Y, Chen Q, Li Y, Zhang J, Xia H, Chen Z, Wang H, Ran D, Yang J
Frontiers in cellular neuroscience 2018;12:214
Frontiers in cellular neuroscience 2018;12:214
CD300A inhibits tumor cell growth by downregulating AKT phosphorylation in human glioblastoma multiforme.
Du X, Liu B, Ding Q, He D, Zhang R, Yang F, Fan H, Teng L, Xin T
International journal of clinical and experimental pathology 2018;11(7):3471-3478
International journal of clinical and experimental pathology 2018;11(7):3471-3478
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer.
Li Q, Ma R, Zhang M
OncoTargets and therapy 2018;11:8435-8444
OncoTargets and therapy 2018;11:8435-8444
Knockdown of HOXA transcript at the distal tip suppresses the growth and invasion and induces apoptosis of oral tongue squamous carcinoma cells.
Mu M, Li Y, Zhan Y, Li X, Zhang B
OncoTargets and therapy 2018;11:8033-8044
OncoTargets and therapy 2018;11:8033-8044
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Wang J, Li M, Cui X, Lv D, Jin L, Khan M, Ma T
OncoTargets and therapy 2018;11:7031-7040
OncoTargets and therapy 2018;11:7031-7040
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
Lu DS, Chen C, Zheng YX, Li DD, Wang GQ, Liu J, Shi J, Zhang F
Frontiers in molecular neuroscience 2018;11:155
Frontiers in molecular neuroscience 2018;11:155
Muscular proteomic profiling of deep pressure ulcers reveals myoprotective role of JAK2 in ischemia and reperfusion injury.
Liu Z, Ren L, Cui X, Guo L, Jiang B, Zhou J, Liang P, Zeng J, He Z, Zhang P
American journal of translational research 2018;10(11):3413-3429
American journal of translational research 2018;10(11):3413-3429
Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.
Ye Y, Wu Y, Wang J
Cancer management and research 2018;10:6399-6407
Cancer management and research 2018;10:6399-6407
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC
Frontiers in aging neuroscience 2018;10:121
Frontiers in aging neuroscience 2018;10:121
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
Zhang M, Ding G, Zhou L, Shen T, Xu X, Zhao T, Jia S, Cao L
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Li S, Wang C
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
Huang Y, Hu Z
Journal of cellular physiology 2018 Sep;233(9):7480-7496
Journal of cellular physiology 2018 Sep;233(9):7480-7496
The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation.
Zhou X, Yong L, Huang Y, Zhu S, Song X, Li B, Zhu J, Wang H
Journal of cellular physiology 2018 Sep;233(9):6902-6910
Journal of cellular physiology 2018 Sep;233(9):6902-6910
Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin-Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis, Endothelial Dysfunction, and Corporal Fibrosis.
Lin H, Wang T, Ruan Y, Liu K, Li H, Wang S, Li M, Liu J
The journal of sexual medicine 2018 Sep;15(9):1246-1259
The journal of sexual medicine 2018 Sep;15(9):1246-1259
Effects of Guanfu total base on Bcl-2 and Bax expression and correlation with atrial fibrillation.
Li Y, Song B, Xu C
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018 Sep-Oct;59(5):274-278
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018 Sep-Oct;59(5):274-278
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Song XQ, Liu YH, Shao J, Zhang ZL, Xie CZ, Qiao X, Bao WG, Xu JY
European journal of medicinal chemistry 2018 Sep 5;157:188-197
European journal of medicinal chemistry 2018 Sep 5;157:188-197
Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing K(ATP) channel.
Zhang R, Zhou X, Shen X, Xie T, Xu C, Zou Z, Dong J, Liao L
Molecular medicine (Cambridge, Mass.) 2018 Sep 4;24(1):47
Molecular medicine (Cambridge, Mass.) 2018 Sep 4;24(1):47
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy.
Wang L, Hu Y, Hao Y, Li L, Zheng C, Zhao H, Niu M, Yin Y, Zhang Z, Zhang Y
Journal of controlled release : official journal of the Controlled Release Society 2018 Sep 28;286:74-84
Journal of controlled release : official journal of the Controlled Release Society 2018 Sep 28;286:74-84
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Xu H, Li Y, Han B, Li Z, Wang B, Jiang P, Zhang J, Ma W, Zhou D, Li X, Ye X
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718
Cattle Encephalon Glycoside and Ignotin Reduce Early Brain Injury and Cognitive Dysfunction after Subarachnoid Hemorrhage in Rats.
Ma K, Li R, Zhao H, Qu J, Mu N, Liu X, Wang S, Yang C, Feng H, Tan L, Li F
Neuroscience 2018 Sep 15;388:181-190
Neuroscience 2018 Sep 15;388:181-190
RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo.
Yu G, Chen J, Li S, Pu P, Huang W, Zhao Y, Peng X, Wang R, Lei H
Life sciences 2018 Sep 1;208:325-332
Life sciences 2018 Sep 1;208:325-332
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Xu N, Fan W, Zhou X, Liu Y, Ma P, Qi S, Gu B
Metabolic brain disease 2018 Oct;33(5):1625-1633
Metabolic brain disease 2018 Oct;33(5):1625-1633
Dual effects of baicalin on osteoclast differentiation and bone resorption.
Lu X, He W, Yang W, Li J, Han W, Liu Q, Zhang T, Jiang J, Qin A, Qian Y
Journal of cellular and molecular medicine 2018 Oct;22(10):5029-5039
Journal of cellular and molecular medicine 2018 Oct;22(10):5029-5039
Catalpol Promotes the Survival and VEGF Secretion of Bone Marrow-Derived Stem Cells and Their Role in Myocardial Repair After Myocardial Infarction in Rats.
Ju X, Xue D, Wang T, Ge B, Zhang Y, Li Z
Cardiovascular toxicology 2018 Oct;18(5):471-481
Cardiovascular toxicology 2018 Oct;18(5):471-481
β-Bourbonene attenuates proliferation and induces apoptosis of prostate cancer cells.
Wang Z, Liu F, Yu JJ, Jin JZ
Oncology letters 2018 Oct;16(4):4519-4525
Oncology letters 2018 Oct;16(4):4519-4525
Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis.
Feng W, Jin L, Xie Q, Huang L, Jiang Z, Ji Y, Li C, Yang L, Wang D
Experimental and therapeutic medicine 2018 Oct;16(4):3464-3470
Experimental and therapeutic medicine 2018 Oct;16(4):3464-3470
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Yu B, Liu D, Zhang H, Xie D, Nie W, Shi K, Yang P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1390-1395
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1390-1395
Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin.
Jiang X, Du Y, Meng X, Zhang H, Zhao D, Zhao L, Chen J, Xiao S, Jiang H
Dose-response : a publication of International Hormesis Society 2018 Oct-Dec;16(4):1559325818813061
Dose-response : a publication of International Hormesis Society 2018 Oct-Dec;16(4):1559325818813061
Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment.
Jiao S, Li J, Liu B, Yang M, Xiu J, Qu D
Bioscience reports 2018 Oct 31;38(5)
Bioscience reports 2018 Oct 31;38(5)
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy.
Sun Y, Dai H, Chen S, Zhang Y, Wu T, Cao X, Zhao G, Xu A, Wang J, Wu L
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Oct 3;26(10):2456-2465
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Oct 3;26(10):2456-2465
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Peng Y, Wang Y, Tang N, Sun D, Lan Y, Yu Z, Zhao X, Feng L, Zhang B, Jin L, Yu F, Ma X, Lv C
Journal of experimental & clinical cancer research : CR 2018 Oct 12;37(1):248
Journal of experimental & clinical cancer research : CR 2018 Oct 12;37(1):248
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, Chen Z, Tao K, Dai J
Cancer medicine 2018 Nov;7(11):5691-5703
Cancer medicine 2018 Nov;7(11):5691-5703
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.
Wu XY, Tian F, Su MH, Wu M, Huang Y, Hu LH, Jin L, Zhu XJ
International immunopharmacology 2018 Nov;64:24-32
International immunopharmacology 2018 Nov;64:24-32
β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors.
You C, Zhang S, Sun Y, Zhang S, Tang G, Tang F, Liu X, Xiao Y, Zhang J, Gong Y, Xie C
International journal of oncology 2018 Nov;53(5):2258-2268
International journal of oncology 2018 Nov;53(5):2258-2268
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
Wang X, Liu W, Wang P, Li S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.
Alduais S, Alduais Y, Wu X, Li H, Mao J
BioFactors (Oxford, England) 2018 Nov;44(6):570-576
BioFactors (Oxford, England) 2018 Nov;44(6):570-576
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
Chen Y, Wei L, Zhang X, Liu X, Chen Y, Zhang S, Zhou L, Li Q, Pan Q, Zhao S, Liu H
Oncology reports 2018 Nov;40(5):2435-2444
Oncology reports 2018 Nov;40(5):2435-2444
Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
Xie Z, Guo Z, Wang Y, Lei J, Yu J
Phytotherapy research : PTR 2018 Nov;32(11):2256-2263
Phytotherapy research : PTR 2018 Nov;32(11):2256-2263
Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.
Cui Y, Zhang Z, Zhang B, Zhao L, Hou C, Zeng Q, Nie J, Yu J, Zhao Y, Gao T, Wang A, Liu H
Toxicology letters 2018 Nov;297:24-33
Toxicology letters 2018 Nov;297:24-33
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Mu Z, Sun Q
Molecular medicine reports 2018 Nov;18(5):4603-4610
Molecular medicine reports 2018 Nov;18(5):4603-4610
Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.
Qiao J, Wang WJ, Zhang Y
Oncology letters 2018 Nov;16(5):6417-6422
Oncology letters 2018 Nov;16(5):6417-6422
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.
Tian T, Sun J, Wang J, Liu Y, Liu H
Oncology letters 2018 Nov;16(5):6133-6139
Oncology letters 2018 Nov;16(5):6133-6139
Activation of α7 nicotinic acetylcholine receptor alleviates Aβ(1-42)-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.
Chang KW, Zong HF, Ma KG, Zhai WY, Yang WN, Hu XD, Xu JH, Chen XL, Ji SF, Qian YH
Neurochemistry international 2018 Nov;120:238-250
Neurochemistry international 2018 Nov;120:238-250
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.
Qin T, Li B, Feng X, Fan S, Liu L, Liu D, Mao J, Lu Y, Yang J, Yu X, Zhang Q, Zhang J, Song B, Li M, Li L
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287
Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.
Dai C, Xiao X, Li D, Tun S, Wang Y, Velkov T, Tang S
Cell death & disease 2018 Nov 26;9(12):1164
Cell death & disease 2018 Nov 26;9(12):1164
An E-selectin targeting and MMP-2-responsive dextran-curcumin polymeric prodrug for targeted therapy of acute kidney injury.
Hu JB, Liu D, Qi J, Lu KJ, Jin FY, Ying XY, You J, Du YZ
Biomaterials science 2018 Nov 20;6(12):3397-3409
Biomaterials science 2018 Nov 20;6(12):3397-3409
Role of capsaicin sensitive sensory nerves in ischemia reperfusion-induced acute kidney injury in rats.
Zhang S, Liu H, Xu Q, Huang F, Xu R, Liu Q, Lv Y
Biochemical and biophysical research communications 2018 Nov 17;506(1):176-182
Biochemical and biophysical research communications 2018 Nov 17;506(1):176-182
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Wang J, Li H, Wang X, Shen T, Wang S, Ren D
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells.
Liu YP, Li L, Xu L, Dai EN, Chen WD
Oncology letters 2018 May;15(5):6527-6532
Oncology letters 2018 May;15(5):6527-6532
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Zhao N, Liang P, Zhuo X, Su C, Zong X, Guo B, Han D, Yan X, Hu S, Zhang Q, Tie X
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Zhou BG, Wei CS, Zhang S, Zhang Z, Gao HM
Journal of cellular biochemistry 2018 May;119(5):3885-3891
Journal of cellular biochemistry 2018 May;119(5):3885-3891
Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway.
Fang Y, Liu G, Xie C, Qian K, Lei X, Liu Q, Liu G, Cao Z, Fu J, Du H, Liu S, Huang S, Hu J, Xu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 May;101:910-919
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 May;101:910-919
The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.
Wang X, Fang H, Cheng Y, Li L, Sun X, Fu T, Huang P, Zhang A, Feng Z, Li C, Huang X, Li G, Du P, Yang H, Fang X, Li F, Gao Q, Liu B
Carcinogenesis 2018 May 3;39(5):708-718
Carcinogenesis 2018 May 3;39(5):708-718
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Chen L, Yan F, Chen W, Zhao L, Zhang J, Lu Q, Liu R
Chemico-biological interactions 2018 May 25;288:12-23
Chemico-biological interactions 2018 May 25;288:12-23
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z
Free radical biology & medicine 2018 May 20;120:228-238
Free radical biology & medicine 2018 May 20;120:228-238
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Wu DD, Gao YR, Li T, Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS, Ji XY
BMC cancer 2018 May 2;18(1):499
BMC cancer 2018 May 2;18(1):499
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Zhang X, Liu Z, Xiao Q, Zeng C, Lai CH, Fan X, Ye Q, Wang Y, Xiong Y
Artificial organs 2018 Mar;42(3):280-289
Artificial organs 2018 Mar;42(3):280-289
Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.
Xu L, Xie Q, Qi L, Wang C, Xu N, Liu W, Yu Y, Li S, Xu Y
Oncology reports 2018 Mar;39(3):985-992
Oncology reports 2018 Mar;39(3):985-992
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Supplementary choline attenuates olive oil lipid emulsion-induced enterocyte apoptosis through suppression of CELF1/AIF pathway.
Yan JK, Zhu J, Gong ZZ, Wen J, Xiao YT, Zhang T, Cai W
Journal of cellular and molecular medicine 2018 Mar;22(3):1562-1573
Journal of cellular and molecular medicine 2018 Mar;22(3):1562-1573
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Liu S, Liu B
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Epigallocatechin-3-gallate alleviates bladder overactivity in a rat model with metabolic syndrome and ovarian hormone deficiency through mitochondria apoptosis pathways.
Lee YL, Lin KL, Wu BN, Chuang SM, Wu WJ, Lee YC, Ho WT, Juan YS
Scientific reports 2018 Mar 29;8(1):5358
Scientific reports 2018 Mar 29;8(1):5358
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)
Marine drugs 2018 Mar 26;16(4)
Potent hydrazone derivatives targeting esophageal cancer cells.
Li LY, Peng JD, Zhou W, Qiao H, Deng X, Li ZH, Li JD, Fu YD, Li S, Sun K, Liu HM, Zhao W
European journal of medicinal chemistry 2018 Mar 25;148:359-371
European journal of medicinal chemistry 2018 Mar 25;148:359-371
Chronic oxycodone induces axonal degeneration in rat brain.
Fan R, Schrott LM, Arnold T, Snelling S, Rao M, Graham D, Cornelius A, Korneeva NL
BMC neuroscience 2018 Mar 23;19(1):15
BMC neuroscience 2018 Mar 23;19(1):15
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy.
Zhang L, Liu W, Wang Q, Li Q, Wang H, Wang J, Teng T, Chen M, Ji A, Li Y
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.
Zhang Q, Li XT, Chen Y, Chen JQ, Zhu JY, Meng Y, Wang XQ, Li Y, Geng SS, Xie CF, Wu JS, Zhong CY, Han HY
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Zhang Y, Li H, Yang X, Jin G, Zhang Y
International journal of biological macromolecules 2018 Jun;112:788-795
International journal of biological macromolecules 2018 Jun;112:788-795
Krüppel-like factor 4 promotes c-Met amplification-mediated gefitinib resistance in non-small-cell lung cancer.
Feng W, Xie Q, Liu S, Ji Y, Li C, Wang C, Jin L
Cancer science 2018 Jun;109(6):1775-1786
Cancer science 2018 Jun;109(6):1775-1786
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X, Zhan Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.
Sun X, Huang S, Wang X, Zhang X, Wang X
Oncotarget 2018 Jun 8;9(44):27574-27584
Oncotarget 2018 Jun 8;9(44):27574-27584
Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.
Wang W, Chen T, Xu H, Ren B, Cheng X, Qi R, Liu H, Wang Y, Yan L, Chen S, Yang Q, Chen C
Molecules (Basel, Switzerland) 2018 Jun 29;23(7)
Molecules (Basel, Switzerland) 2018 Jun 29;23(7)
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Li XY, Liang JW, Mohamed O K, Zhang TJ, Lu GQ, Meng FH
European journal of medicinal chemistry 2018 Jun 25;154:267-279
European journal of medicinal chemistry 2018 Jun 25;154:267-279
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
Han B, Jiang P, Liu W, Xu H, Li Y, Li Z, Ma H, Yu Y, Li X, Ye X
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
Hyperglycemia-induced Bcl-2/Bax-mediated apoptosis of Schwann cells via mTORC1/S6K1 inhibition in diabetic peripheral neuropathy.
Zhu L, Hao J, Cheng M, Zhang C, Huo C, Liu Y, Du W, Zhang X
Experimental cell research 2018 Jun 15;367(2):186-195
Experimental cell research 2018 Jun 15;367(2):186-195
SIRT3 aggravates metformin-induced energy stress and apoptosis in ovarian cancer cells.
Wu Y, Gao WN, Xue YN, Zhang LC, Zhang JJ, Lu SY, Yan XY, Yu HM, Su J, Sun LK
Experimental cell research 2018 Jun 15;367(2):137-149
Experimental cell research 2018 Jun 15;367(2):137-149
Atrazine exposure improves the proliferation of H22 cells in vitro and in vivo.
Tian Y, He J, Liu N, Huang D, Liu Z, Yang Y, Chen J, Zhao B, Zhao S, Liang B
RSC advances 2018 Jun 13;8(39):21759-21767
RSC advances 2018 Jun 13;8(39):21759-21767
Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum.
Chai W, Chen L, Lian XY, Zhang Z
Planta medica 2018 Jul;84(11):786-794
Planta medica 2018 Jul;84(11):786-794
PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis.
Shen L, Sun B, Sheng J, Yu S, Li Y, Xu H, Su J, Sun L
International journal of oncology 2018 Jul;53(1):404-416
International journal of oncology 2018 Jul;53(1):404-416
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Lu X, Liu T, Chen K, Xia Y, Dai W, Xu S, Xu L, Wang F, Wu L, Li J, Li S, Wang W, Yu Q, Feng J, Fan X, Zhou Y, Niu P, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.
Chai FN, Ma WY, Zhang J, Xu HS, Li YF, Zhou QD, Li XG, Ye XL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1002-1011
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1002-1011
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease.
Jiao W, Wang Y, Kong L, Ou-Yang T, Meng Q, Fu Q, Hu Z
Biochemical and biophysical research communications 2018 Jul 2;501(4):1016-1022
Biochemical and biophysical research communications 2018 Jul 2;501(4):1016-1022
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Lian S, Wang D, Xu B, Guo W, Wang L, Li W, Ji H, Wang J, Kong F, Zhen L, Li S, Zhang L, Guo J, Yang H
Behavioural brain research 2018 Jul 2;346:1-10
Behavioural brain research 2018 Jul 2;346:1-10
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Zhang J, Liu L, Wang J, Ren B, Zhang L, Li W
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins.
Tang J, He A, Yan H, Jia G, Liu G, Chen X, Cai J, Tian G, Shang H, Zhao H
Scientific reports 2018 Jul 13;8(1):10601
Scientific reports 2018 Jul 13;8(1):10601
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, He C, Zheng C, Li K, Ma X, Xiang G
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Liu C, Xing J, Gao Y
Thoracic cancer 2018 Jan;9(1):105-111
Thoracic cancer 2018 Jan;9(1):105-111
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Protective Effect of Selenoprotein X Against Oxidative Stress-Induced Cell Apoptosis in Human Hepatocyte (LO2) Cells via the p38 Pathway.
Tang JY, He AH, Jia G, Liu GM, Chen XL, Cai JY, Shang HY, Liao JQ, Zhao H
Biological trace element research 2018 Jan;181(1):44-53
Biological trace element research 2018 Jan;181(1):44-53
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Liu L, Zhang L, Wang J, Zhao X, Xu Q, Lu Y, Zuo Y, Chen L, Du J, Lian Y, Zhang Q
Molecular medicine reports 2018 Jan;17(1):835-842
Molecular medicine reports 2018 Jan;17(1):835-842
Molecular mechanisms of Ellis‑van Creveld gene variations in ventricular septal defect.
Liu F, Liu X, Xu Z, Yuan P, Zhou Q, Jin J, Yan X, Xu Z, Cao Q, Yu J, Cheng Y, Wan R, Hong K
Molecular medicine reports 2018 Jan;17(1):1527-1536
Molecular medicine reports 2018 Jan;17(1):1527-1536
Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.
Wang Y, Gao H, Wu T, Wang Z, Song F, Chen A, Zhang J, Zhang W, Zhang H, Yu J
Oncology letters 2018 Jan;15(1):863-870
Oncology letters 2018 Jan;15(1):863-870
Tetrahydroxystilbene glucoside relieves the chronic inflammatory pain by inhibiting neuronal apoptosis, microglia activation, and GluN2B overexpression in anterior cingulate cortex.
Fan YF, Guan SY, Luo L, Li YJ, Yang L, Zhou XX, Guo GD, Zhao MG, Yang Q, Liu G
Molecular pain 2018 Jan-Dec;14:1744806918814367
Molecular pain 2018 Jan-Dec;14:1744806918814367
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Zhang J, Yuan JP, Wang Q, Shao LH, Liu SP, Firestone RA, Hong YP, Li JG, Xin YC, Li Y
Oncotarget 2018 Jan 5;9(2):1957-1968
Oncotarget 2018 Jan 5;9(2):1957-1968
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y
European journal of medicinal chemistry 2018 Jan 20;144:817-842
European journal of medicinal chemistry 2018 Jan 20;144:817-842
Propranolol enhanced the anti-tumor effect of sunitinib by inhibiting proliferation and inducing G0/G1/S phase arrest in malignant melanoma.
Kuang X, Qi M, Peng C, Zhou C, Su J, Zeng W, Liu H, Zhang J, Chen M, Shen M, Xie X, Li F, Zhao S, Li Q, Luo Z, Chen J, Tao J, He Y, Chen X
Oncotarget 2018 Jan 2;9(1):802-811
Oncotarget 2018 Jan 2;9(1):802-811
Exosomes derived from imatinib-resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug-resistant trait by delivering miR-365.
Min QH, Wang XZ, Zhang J, Chen QG, Li SQ, Liu XQ, Li J, Liu J, Yang WM, Jiang YH, Xu YM, Lin J, Gao QF, Sun F, Zhang L, Huang B
Experimental cell research 2018 Jan 15;362(2):386-393
Experimental cell research 2018 Jan 15;362(2):386-393
Proteasome Inhibitor Carbobenzoxy-L-Leucyl-L-Leucyl-L-Leucinal (MG132) Enhances Therapeutic Effect of Paclitaxel on Breast Cancer by Inhibiting Nuclear Factor (NF)-κB Signaling.
Zhang Y, Yang B, Zhao J, Li X, Zhang L, Zhai Z
Medical science monitor : international medical journal of experimental and clinical research 2018 Jan 15;24:294-304
Medical science monitor : international medical journal of experimental and clinical research 2018 Jan 15;24:294-304
Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4.
An J, Liu T, She R, Wu Q, Tian J, Shi R, Hao W, Ren X, Yang Y, Lu Y, Yang Y, Wu Y
Oncotarget 2018 Jan 12;9(4):4475-4484
Oncotarget 2018 Jan 12;9(4):4475-4484
MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer.
Yu SJ, Yang L, Hong Q, Kuang XY, Di GH, Shao ZM
BMC cancer 2018 Jan 12;18(1):74
BMC cancer 2018 Jan 12;18(1):74
Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration.
You B, Liu Y, Chen J, Huang X, Peng H, Liu Z, Tang Y, Zhang K, Xu Q, Li X, Cheng G, Shi R, Zhang G
Cardiovascular research 2018 Jan 1;114(1):188-199
Cardiovascular research 2018 Jan 1;114(1):188-199
TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.
Xie Q, Xu Y, Gao W, Zhang Y, Su J, Liu Y, Guo Y, Dou M, Hu K, Sun L
International journal of molecular medicine 2018 Feb;41(2):809-817
International journal of molecular medicine 2018 Feb;41(2):809-817
Autophagy relieves the function inhibition and apoptosis‑promoting effects on osteoblast induced by glucocorticoid.
Han Y, Zhang L, Xing Y, Zhang L, Chen X, Tang P, Chen Z
International journal of molecular medicine 2018 Feb;41(2):800-808
International journal of molecular medicine 2018 Feb;41(2):800-808
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
He X, Yuan W, Li Z, Hou Y, Liu F, Feng J
Toxicology letters 2018 Feb;283:58-68
Toxicology letters 2018 Feb;283:58-68
Propofol protects against endotoxin-induced myocardial injury by inhibiting NF-κB-mediated inflammation.
Yang Z, Cheng F, Yan G, Xiong L, Liu H
Experimental and therapeutic medicine 2018 Feb;15(2):2032-2036
Experimental and therapeutic medicine 2018 Feb;15(2):2032-2036
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Su Y, Li X, Ma J, Zhao J, Liu S, Wang G, Edwards H, Taub JW, Lin H, Ge Y
Biochemical pharmacology 2018 Feb;148:13-26
Biochemical pharmacology 2018 Feb;148:13-26
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
Wang J, Tian L, Khan MN, Zhang L, Chen Q, Zhao Y, Yan Q, Fu L, Liu J
Cancer letters 2018 Feb 28;415:73-85
Cancer letters 2018 Feb 28;415:73-85
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway.
Lei D, Shao Z, Zhou X, Yuan H
Oncotarget 2018 Feb 23;9(15):12137-12153
Oncotarget 2018 Feb 23;9(15):12137-12153
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.
Jiang L, Zhang J, Hu N, Liu A, Zhu H, Li L, Tian Y, Chen X, Quan L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Dec;96(6):786-796
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Dec;96(6):786-796
Blocking FGFR4 exerts distinct anti-tumorigenic effects in esophageal squamous cell carcinoma.
Xin Z, Song X, Jiang B, Gongsun X, Song L, Qin Q, Wang Q, Shi M, Liu X
Thoracic cancer 2018 Dec;9(12):1687-1698
Thoracic cancer 2018 Dec;9(12):1687-1698
Mild Hypothermia Protects Renal Function in Ischemia-reperfusion Kidney: An Experimental Study in Mice.
Xia Z, Wang W, Xiao Q, Ye Q, Zhang X, Wang Y
Transplantation proceedings 2018 Dec;50(10):3816-3821
Transplantation proceedings 2018 Dec;50(10):3816-3821
Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway.
Zhang X, Feng H, Du J, Sun J, Li D, Hasegawa T, Amizuka N, Li M
International journal of molecular medicine 2018 Dec;42(6):3135-3148
International journal of molecular medicine 2018 Dec;42(6):3135-3148
Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.
Zhao W, Che C, Liu K, Zhang J, Jiang N, Yuan K, Zhao G
Cornea 2018 Dec;37(12):1579-1585
Cornea 2018 Dec;37(12):1579-1585
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.
Chen Y, Li Y, Wang XQ, Meng Y, Zhang Q, Zhu JY, Chen JQ, Cao WS, Wang XQ, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis.
Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q
Cell research 2018 Dec;28(12):1171-1185
Cell research 2018 Dec;28(12):1171-1185
Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Liang Z, Yuan Z, Li G, Fu F, Shan Y
Journal of medicinal food 2018 Dec;21(12):1218-1227
Journal of medicinal food 2018 Dec;21(12):1218-1227
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
Cancer science 2018 Dec;109(12):3762-3773
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH
Cancers 2018 Dec 31;11(1)
Cancers 2018 Dec 31;11(1)
MAN1B1 is associated with poor prognosis and modulates proliferation and apoptosis in bladder cancer.
Wang HF, Wu JH, Gai JW, Yang SQ, Ma QT, Ma HS, Feng Q
Gene 2018 Dec 30;679:314-319
Gene 2018 Dec 30;679:314-319
Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway.
Liu B, Xu L, Dai EN, Tian JX, Li JM
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.
Wang J, Qin L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X
Organic & biomolecular chemistry 2018 Dec 19;17(1):195-202
Organic & biomolecular chemistry 2018 Dec 19;17(1):195-202
Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.
Yang Y, Yu S, Liu N, Xu H, Gong Y, Wu Y, Wang P, Su X, Liao Y, De Saeger S, Humpf HU, Wu A
Toxicological sciences : an official journal of the Society of Toxicology 2018 Dec 1;166(2):370-381
Toxicological sciences : an official journal of the Society of Toxicology 2018 Dec 1;166(2):370-381
Ectopic expression of Miro 1 ameliorates seizures and inhibits hippocampal neurodegeneration in a mouse model of pilocarpine epilepsy.
Zhang H, Lian Y, Xie N, Zheng Y
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Aug;96(4):468-474
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Aug;96(4):468-474
Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.
Yu Z, Tian X, Peng Y, Sun Z, Wang C, Tang N, Li B, Jian Y, Wang W, Huo X, Ma X
Journal of pineal research 2018 Aug;65(1):e12478
Journal of pineal research 2018 Aug;65(1):e12478
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Bai Z, Gao M, Xu X, Zhang H, Xu J, Guan Q, Wang Q, Du J, Li Z, Zuo D, Zhang W, Wu Y
Cell proliferation 2018 Aug;51(4):e12450
Cell proliferation 2018 Aug;51(4):e12450
Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPARγ after experimental subarachnoid hemorrhage.
Tu L, Yang XL, Zhang Q, Wang Q, Tian T, Liu D, Qu X, Tian JY
Neurological research 2018 Aug;40(8):702-708
Neurological research 2018 Aug;40(8):702-708
Canonical Transient Receptor Potential Channel 3 Contributes to Febrile Seizure Inducing Neuronal Cell Death and Neuroinflammation.
Sun D, Ma H, Ma J, Wang J, Deng X, Hu C, Deng X
Cellular and molecular neurobiology 2018 Aug;38(6):1215-1226
Cellular and molecular neurobiology 2018 Aug;38(6):1215-1226
HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.
Zhang R, Wang J
Cancer science 2018 Aug;109(8):2446-2457
Cancer science 2018 Aug;109(8):2446-2457
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Cheng L, Chen L, Wei X, Wang Y, Ren Z, Zeng S, Zhang X, Wen H, Gao C, Liu H
Journal of neuroinflammation 2018 Aug 29;15(1):243
Journal of neuroinflammation 2018 Aug 29;15(1):243
Improvement of vascular dysfunction by argirein through inhibiting endothelial cell apoptosis associated with ET-1/Nox4 signal pathway in diabetic rats.
Su J, An XR, Li Q, Li XX, Cong XD, Xu M
Scientific reports 2018 Aug 22;8(1):12620
Scientific reports 2018 Aug 22;8(1):12620
Hepatic, Metabolic, and Toxicity Evaluation of Repeated Oral Administration of SnS2 Nanoflowers in Mice.
Bai D, Li Q, Xiong Y, Wang C, Shen P, Bai L, Yuan L, Wu P
Toxicological sciences : an official journal of the Society of Toxicology 2018 Aug 1;164(2):501-511
Toxicological sciences : an official journal of the Society of Toxicology 2018 Aug 1;164(2):501-511
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Wang X, Su GY, Zhao C, Qu FZ, Wang P, Zhao YQ
Journal of ginseng research 2018 Apr;42(2):133-143
Journal of ginseng research 2018 Apr;42(2):133-143
Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
Cellular and molecular neurobiology 2018 Apr;38(3):735-745
Endoplasmic Reticulum Stress Facilitates the Survival and Proliferation of Nucleus Pulposus Cells in TNF-α Stimulus by Activating Unfolded Protein Response.
Chen L, Liu L, Xie ZY, Wang F, Sinkemani A, Zhang C, Wang XH, Wang K, Hong X, Wu XT
DNA and cell biology 2018 Apr;37(4):347-358
DNA and cell biology 2018 Apr;37(4):347-358
CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.
Zhao J, Xiang X, Zhang H, Jiang D, Liang Y, Qing W, Liu L, Zhao Q, He Z
Experimental neurology 2018 Apr;302:22-33
Experimental neurology 2018 Apr;302:22-33
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca(2+) -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Sun Y, Wang C, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2018 Apr;233(4):3066-3079
Journal of cellular physiology 2018 Apr;233(4):3066-3079
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Zhang H, Cao Y, Chen Y, Li G, Yu H
Oncology letters 2018 Apr;15(4):5739-5743
Oncology letters 2018 Apr;15(4):5739-5743
Celecoxib enhances sensitivity to chemotherapy drugs of T-cell lymphoma.
Ma M, Yang X, Zhao L, Wang X, Liu L, Jiao W, Wei Y, Shan B
Oncology letters 2018 Apr;15(4):4649-4656
Oncology letters 2018 Apr;15(4):4649-4656
Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells.
Xia K, Zhang P, Hu J, Hou H, Xiong M, Xiong J, Yan N
Oncology letters 2018 Apr;15(4):4344-4350
Oncology letters 2018 Apr;15(4):4344-4350
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Liu DZ, Cheng Y, Cai RQ, Wang Bd WW, Cui H, Liu M, Zhang BL, Mei QB, Zhou SY
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Zhang X, Wang Y, Velkov T, Tang S, Dai C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
PSMB8 regulates glioma cell migration, proliferation, and apoptosis through modulating ERK1/2 and PI3K/AKT signaling pathways.
Yang BY, Song JW, Sun HZ, Xing JC, Yang ZH, Wei CY, Xu TY, Yu ZN, Zhang YN, Wang YF, Chang H, Xu ZP, Hou M, Ji MJ, Zhang YS
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Apr;100:205-212
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Apr;100:205-212
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Dai C, Ciccotosto GD, Cappai R, Wang Y, Tang S, Hoyer D, Schneider EK, Velkov T, Xiao X
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
miR-501 is upregulated in cervical cancer and promotes cell proliferation, migration and invasion by targeting CYLD.
Sanches JGP, Xu Y, Yabasin IB, Li M, Lu Y, Xiu X, Wang L, Mao L, Shen J, Wang B, Hou L, Ju J, Zhao J, Song B
Chemico-biological interactions 2018 Apr 1;285:85-95
Chemico-biological interactions 2018 Apr 1;285:85-95
COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.
Yin J, Xia W, Li Y, Guo C, Zhang Y, Huang S, Jia Z, Zhang A
American journal of translational research 2017;9(9):3967-3976
American journal of translational research 2017;9(9):3967-3976
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Cai Z, Zou Y, Hu H, Lu C, Sun W, Jiang L, Hu G
American journal of translational research 2017;9(5):2645-2655
American journal of translational research 2017;9(5):2645-2655
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Mehmood T, Maryam A, Tian X, Khan M, Ma T
Journal of Cancer 2017;8(18):3707-3717
Journal of Cancer 2017;8(18):3707-3717
Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage.
Qie X, Wen D, Guo H, Xu G, Liu S, Shen Q, Liu Y, Zhang W, Cong B, Ma C
Frontiers in pharmacology 2017;8:639
Frontiers in pharmacology 2017;8:639
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
Wang A, Ning Z, Lu C, Gao W, Liang J, Yan Q, Tan G, Liu J
Frontiers in pharmacology 2017;8:274
Frontiers in pharmacology 2017;8:274
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Wang J, Yu Z, Wang C, Tian X, Huo X, Wang Y, Sun C, Feng L, Ma J, Zhang B, Yang Q, Ma X, Xu Y
American journal of cancer research 2017;7(6):1270-1284
American journal of cancer research 2017;7(6):1270-1284
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy.
Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH
Frontiers in cellular and infection microbiology 2017;7:223
Frontiers in cellular and infection microbiology 2017;7:223
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Liu LS, Bai XQ, Gao Y, Wu Q, Ren Z, Li Q, Pan LH, He NY, Peng J, Tang ZH
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.
Yu W, Li L, Zheng F, Yang W, Zhao S, Tian C, Yin W, Chen Y, Guo W, Zou L, Deng W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(2):467-478
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(2):467-478
Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia.
Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X, Xia Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):279-292
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):279-292
N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression.
Li P, Liang Z, Hou G, Song L, Zhang R, Gan Y, Zhang C, Xu Y, Zhou Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):229-239
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):229-239
N-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression.
Wang Z, Leng J, Zhao Y, Yu D, Xu F, Song Q, Qu Z, Zhuang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(6):2327-2337
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(6):2327-2337
Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.
Zou J, Zhang Y, Sun J, Wang X, Tu H, Geng S, Liu R, Chen Y, Bi Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Ma S, Zhong D, Ma P, Li G, Hua W, Sun Y, Liu N, Zhang L, Zhang W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model.
Zhang Y, Liao P, Zhu M, Li W, Hu D, Guan S, Chen L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(3):849-864
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(3):849-864
Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway.
Wu L, Zhang Q, Dai W, Li S, Feng J, Li J, Liu T, Xu S, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Zhou Y, Fan X, Guo C
Gastroenterology research and practice 2017;2017:9724217
Gastroenterology research and practice 2017;2017:9724217
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
Wu X, Zhu H, Yan J, Khan M, Yu X
BioMed research international 2017;2017:4734127
BioMed research international 2017;2017:4734127
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Wang Y, Gu YH, Liu M, Bai Y, Liang LY, Wang HL
Oxidative medicine and cellular longevity 2017;2017:4310475
Oxidative medicine and cellular longevity 2017;2017:4310475
Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.
Liu Z, Zhang X, Xiao Q, Ye S, Lai CH, Luo J, Huang X, Wang W, Zeng C, Zhong Z, Fan X, Xia Z, Xiong Y, Mao X, Ye Q, Wang Y
Oxidative medicine and cellular longevity 2017;2017:3861914
Oxidative medicine and cellular longevity 2017;2017:3861914
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Deng F, Wang S, Cai S, Hu Z, Xu R, Wang J, Feng D, Zhang L
Oxidative medicine and cellular longevity 2017;2017:3542149
Oxidative medicine and cellular longevity 2017;2017:3542149
Relaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro.
Xie XC, Cao Y, Yang X, Xu QH, Wei W, Wang M
BioMed research international 2017;2017:2869405
BioMed research international 2017;2017:2869405
MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS.
Chen Y, Li Y, Xu H, Li G, Ma Y, Pang YJ
African journal of traditional, complementary, and alternative medicines : AJTCAM 2017;14(2):348-355
African journal of traditional, complementary, and alternative medicines : AJTCAM 2017;14(2):348-355
Downregulation of UBC9 promotes apoptosis of activated human LX-2 hepatic stellate cells by suppressing the canonical NF-κB signaling pathway.
Fang S, Yuan J, Shi Q, Xu T, Fu Y, Wu Z, Guo W
PloS one 2017;12(3):e0174374
PloS one 2017;12(3):e0174374
The effect of cavernous nerve traction on erectile function in rats.
Li H, Chen L, Wang T, Wang S, Liu J
PloS one 2017;12(10):e0186077
PloS one 2017;12(10):e0186077
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice.
Feng J, Zhang Q, Mo W, Wu L, Li S, Li J, Liu T, Xu S, Fan X, Guo C
Drug design, development and therapy 2017;11:1989-2006
Drug design, development and therapy 2017;11:1989-2006
Propofol alleviates hepatic ischemia/reperfusion injury via the activation of the Sirt1 pathway.
Liu Y, Du X, Zhang S, Liu X, Xu G
International journal of clinical and experimental pathology 2017;10(11):10959-10968
International journal of clinical and experimental pathology 2017;10(11):10959-10968
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis.
Wang B, Shen J, Wang J
OncoTargets and therapy 2017;10:5303-5309
OncoTargets and therapy 2017;10:5303-5309
Hyperlipidemia impairs erectile function in rats by causing cavernosal fibrosis.
Li R, Cui K, Wang T, Wang S, Li X, Qiu J, Yu G, Liu J, Wen B, Rao K
Andrologia 2017 Sep;49(7)
Andrologia 2017 Sep;49(7)
Visfatin induces the apoptosis of endothelial progenitor cells via the induction of pro-inflammatory mediators through the NF-κB pathway.
Sun L, Chen S, Gao H, Ren L, Song G
International journal of molecular medicine 2017 Sep;40(3):637-646
International journal of molecular medicine 2017 Sep;40(3):637-646
Puerarin increases the chemosensitivity of hepatocellular carcinoma cells.
Wu Z, Wu J, Fang P, Kan S
Oncology letters 2017 Sep;14(3):3006-3010
Oncology letters 2017 Sep;14(3):3006-3010
Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways.
Zuo D, Sun F, Cui J, Liu Y, Liu Z, Zhou X, Li Z, Wu Y
Scientific reports 2017 Sep 5;7(1):10523
Scientific reports 2017 Sep 5;7(1):10523
The natural product fucoidan ameliorates hepatic ischemia-reperfusion injury in mice.
Li J, Zhang Q, Li S, Dai W, Feng J, Wu L, Liu T, Chen K, Xia Y, Lu J, Zhou Y, Fan X, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:687-696
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:687-696
In vitro anticancer activities of osthole against renal cell carcinoma cells.
Liu L, Mao J, Wang Q, Zhang Z, Wu G, Tang Q, Zhao B, Li L, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:1020-1027
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:1020-1027
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, Song J, Xing J, Sun D, Hou Q, Peng Y, Zhao J, Sun X, Song X
International journal of oncology 2017 Oct;51(4):1249-1260
International journal of oncology 2017 Oct;51(4):1249-1260
Enhanced antitumor activity in A431 cells via encapsulation of 20(R)-ginsenoside Rg3 in PLGA nanoparticles.
Zhang S, Liu J, Ge B, Du M, Fu L, Fu Y, Yan Q
Drug development and industrial pharmacy 2017 Oct;43(10):1734-1741
Drug development and industrial pharmacy 2017 Oct;43(10):1734-1741
14,15-EET Suppresses Neuronal Apoptosis in Ischemia-Reperfusion Through the Mitochondrial Pathway.
Geng HX, Li RP, Li YG, Wang XQ, Zhang L, Deng JB, Wang L, Deng JX
Neurochemical research 2017 Oct;42(10):2841-2849
Neurochemical research 2017 Oct;42(10):2841-2849
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Li D, Dai C, Yang X, Wang F, Yu X, Xiao X, Tang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.
Zhou H, Zheng L, Lu K, Gao Y, Guo L, Xu W, Wang X
Medical science monitor : international medical journal of experimental and clinical research 2017 Oct 7;23:4817-4825
Medical science monitor : international medical journal of experimental and clinical research 2017 Oct 7;23:4817-4825
An autophagic mechanism is involved in the 6-hydroxydopamine-induced neurotoxicity in vivo.
He X, Yuan W, Li Z, Feng J
Toxicology letters 2017 Oct 5;280:29-40
Toxicology letters 2017 Oct 5;280:29-40
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q
Cell death & disease 2017 Oct 26;8(10):e3145
Cell death & disease 2017 Oct 26;8(10):e3145
Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.
Ma T, Yin X, Han R, Ding J, Zhang H, Han X, Li D
International journal of environmental research and public health 2017 Oct 24;14(10)
International journal of environmental research and public health 2017 Oct 24;14(10)
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Sheng N, Yan L, You W, Tan G, Gong J, Chen H, Yang Y, Hu L, Wang Z
Acta biochimica et biophysica Sinica 2017 Oct 1;49(10):926-934
Acta biochimica et biophysica Sinica 2017 Oct 1;49(10):926-934
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Zhao Y, Jing Z, Lv J, Zhang Z, Lin J, Cao X, Zhao Z, Liu P, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats.
Wu F, Yao W, Yang J, Zhang M, Xu Y, Hao Y, Yan L, Niu Y, Sun T, Yu J, Zhou R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:1161-1168
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:1161-1168
Cysteine-rich buccal gland protein suppressed the proliferation, migration and invasion of hela cells through akt pathway.
Han J, Liu Y, Jiang Q, Xiao R
IUBMB life 2017 Nov;69(11):856-866
IUBMB life 2017 Nov;69(11):856-866
Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide.
Tan MJ, Cao XW, Li PF, Zhai YZ, Zhou Y, Liu YJ, Zhao J, Wang FJ
Biotechnology and applied biochemistry 2017 Nov;64(6):918-926
Biotechnology and applied biochemistry 2017 Nov;64(6):918-926
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Peng Z, Gong X, Yang Y, Huang L, Zhang Q, Zhang P, Wan R, Zhang B
International immunopharmacology 2017 Nov;52:281-289
International immunopharmacology 2017 Nov;52:281-289
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K
International immunopharmacology 2017 Nov;52:168-175
International immunopharmacology 2017 Nov;52:168-175
Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations.
Yang Z, Geng Y, Yao Z, Jia H, Bai Y, Wang W
Neurochemical research 2017 Nov;42(11):3160-3169
Neurochemical research 2017 Nov;42(11):3160-3169
Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression.
Chen L, Cong D, Li Y, Wang D, Li Q, Hu S
Ultrasonics sonochemistry 2017 Nov;39:654-661
Ultrasonics sonochemistry 2017 Nov;39:654-661
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
Xue TF, Ding X, Ji J, Yan H, Huang JY, Guo XD, Yang J, Sun XL
Journal of pharmacological sciences 2017 Nov;135(3):105-113
Journal of pharmacological sciences 2017 Nov;135(3):105-113
Correlation between miR-19a inhibition and radiosensitivity in SiHa cervical cancer cells.
Wang Y, Wang Y, Zhong W, Gulina K
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2017 Nov-Dec;22(6):1505-1508
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2017 Nov-Dec;22(6):1505-1508
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, Li J, Li S, Wu L, Feng J, Wang W, Lu X, Liu T, Wang F, Dai W, Fan X, Mo W, Xu L, Guo C
Scientific reports 2017 Nov 9;7(1):15175
Scientific reports 2017 Nov 9;7(1):15175
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
Yao X, Tang H, Ren Q, Zhao X, Zuo H, Li Z
Oncotarget 2017 Nov 7;8(55):94197-94209
Oncotarget 2017 Nov 7;8(55):94197-94209
COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level.
Zhang H, Zhong A, Sun J, Chen M, Xie S, Zheng H, Wang Y, Yu Y, Guo L, Lu R
Biochemical and biophysical research communications 2017 Nov 4;493(1):85-93
Biochemical and biophysical research communications 2017 Nov 4;493(1):85-93
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.
Xu W, Yu H, Ma R, Ma L, Liu Q, Shan H, Wu C, Zhang R, Zhou Y, Shan H
Oncotarget 2017 Nov 21;8(59):100034-100044
Oncotarget 2017 Nov 21;8(59):100034-100044
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F
European journal of pharmacology 2017 Nov 15;815:282-289
European journal of pharmacology 2017 Nov 15;815:282-289
miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin.
Han J, Li J, Tang K, Zhang H, Guo B, Hou N, Huang C
Experimental cell research 2017 Nov 15;360(2):328-336
Experimental cell research 2017 Nov 15;360(2):328-336
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Huang Z, Yang G, Shen T, Wang X, Li H, Ren D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Liu C, Hao Y, Yin F, Zhang Y, Liu J
Cell biology international 2017 May;41(5):544-554
Cell biology international 2017 May;41(5):544-554
15-Deoxy-Δ(12,14)-prostaglandin J(2) alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy.
Chen K, Li JJ, Li SN, Feng J, Liu T, Wang F, Dai WQ, Xia YJ, Lu J, Zhou YQ, Guo CY
Acta pharmacologica Sinica 2017 May;38(5):672-687
Acta pharmacologica Sinica 2017 May;38(5):672-687
Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.
Khan SH, Zhao D, Shah SZ, Hassan MF, Zhu T, Song Z, Zhou X, Yang L
Cellular and molecular neurobiology 2017 May;37(4):717-728
Cellular and molecular neurobiology 2017 May;37(4):717-728
Clinical Significance and Tumor-Suppressive Function of miR-516b in Nonsmall Cell Lung Cancer.
Zhu J, Zhang Y, Yang X, Jin L
Cancer biotherapy & radiopharmaceuticals 2017 May;32(4):115-123
Cancer biotherapy & radiopharmaceuticals 2017 May;32(4):115-123
The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
Gao C, Sun R, Xie YR, Jiang AL, Lin M, Li M, Chen ZW, Zhang P, Jin H, Feng JP
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(10):1034-1043
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(10):1034-1043
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Liu S, Sun Z, Chu P, Li H, Ahsan A, Zhou Z, Zhang Z, Sun B, Wu J, Xi Y, Han G, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.
Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W
The EMBO journal 2017 May 2;36(9):1243-1260
The EMBO journal 2017 May 2;36(9):1243-1260
Synthesis, characterization, and radioprotective activity of α,β-unsaturated aryl sulfone analogs and their Tempol conjugates.
Zhou N, Feng T, Shen X, Cui J, Wu R, Wang L, Wang S, Zhang S, Chen H
MedChemComm 2017 May 1;8(5):1063-1068
MedChemComm 2017 May 1;8(5):1063-1068
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.
Jiang Q, Li Q, Han J, Gou M, Zheng Y, Li B, Xiao R, Wang J
International journal of biological macromolecules 2017 Mar;96:652-668
International journal of biological macromolecules 2017 Mar;96:652-668
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
Zhu Y, Jiang Y, Shi L, Du L, Xu X, Wang E, Sun Y, Guo X, Zou B, Wang H, Wang C, Sun L, Zhen Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
Yang W, Yang S, Zhang M, Gao D, He T, Guo M
Genes & cancer 2017 Mar;8(3-4):528-535
Genes & cancer 2017 Mar;8(3-4):528-535
The Anticonvulsant and Neuroprotective Effects of Oxysophocarpine on Pilocarpine-Induced Convulsions in Adult Male Mice.
Liu G, Wang J, Deng XH, Ma PS, Li FM, Peng XD, Niu Y, Sun T, Li YX, Yu JQ
Cellular and molecular neurobiology 2017 Mar;37(2):339-349
Cellular and molecular neurobiology 2017 Mar;37(2):339-349
Mitochondrial Dysfunction and Ca(2+) Overload in Injured Sertoli Cells Exposed to Bisphenol A.
Wang C, Qi S, Liu C, Yang A, Fu W, Quan C, Duan P, Yu T, Yang K
Environmental toxicology 2017 Mar;32(3):823-831
Environmental toxicology 2017 Mar;32(3):823-831
FTY720 Supplementation Partially Improves Erectile Dysfunction in Rats With Streptozotocin-Induced Type 1 Diabetes Through Inhibition of Endothelial Dysfunction and Corporal Fibrosis.
Cui K, Ruan Y, Wang T, Rao K, Chen Z, Wang S, Liu J
The journal of sexual medicine 2017 Mar;14(3):323-335
The journal of sexual medicine 2017 Mar;14(3):323-335
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.
Wu D, Luo N, Wang L, Zhao Z, Bu H, Xu G, Yan Y, Che X, Jiao Z, Zhao T, Chen J, Ji A, Li Y, Lee GD
Scientific reports 2017 Mar 28;7(1):455
Scientific reports 2017 Mar 28;7(1):455
Beneficial effects of Lycium barbarum polysaccharide on spermatogenesis by improving antioxidant activity and inhibiting apoptosis in streptozotocin-induced diabetic male mice.
Shi GJ, Zheng J, Wu J, Qiao HQ, Chang Q, Niu Y, Sun T, Li YX, Yu JQ
Food & function 2017 Mar 22;8(3):1215-1226
Food & function 2017 Mar 22;8(3):1215-1226
Expression of Nischarin negatively correlates with estrogen receptor and alters apoptosis, migration and invasion in human breast cancer.
Chang C, Wei W, Han D, Meng J, Zhu F, Xiao Y, Wu G, Shi X, Zhang L
Biochemical and biophysical research communications 2017 Mar 11;484(3):536-542
Biochemical and biophysical research communications 2017 Mar 11;484(3):536-542
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.
Pang J, Chen Y, Kuai L, Yang P, Peng J, Wu Y, Chen Y, Vitek MP, Chen L, Sun X, Jiang Y
Translational stroke research 2017 Jun;8(3):257-272
Translational stroke research 2017 Jun;8(3):257-272
Acid sphingomyelinase/ceramide regulates carotid intima-media thickness in simulated weightless rats.
Cheng YP, Zhang HJ, Su YT, Meng XX, Xie XP, Chang YM, Bao JX
Pflugers Archiv : European journal of physiology 2017 Jun;469(5-6):751-765
Pflugers Archiv : European journal of physiology 2017 Jun;469(5-6):751-765
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, Ma X, Huang C, Wu R, Xie C, Geng S, Wu J, Zhong C, Han H
The Journal of nutritional biochemistry 2017 Jun;44:80-91
The Journal of nutritional biochemistry 2017 Jun;44:80-91
Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway.
Zhang Y, Xiao F, Liu X, Liu K, Zhou X, Zhong C
Toxicology in vitro : an international journal published in association with BIBRA 2017 Jun;41:232-244
Toxicology in vitro : an international journal published in association with BIBRA 2017 Jun;41:232-244
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Xie XC, Zhao N, Xu QH, Yang X, Xia WK, Chen Q, Wang M, Fei X
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, Han HY
Nutrients 2017 Jun 3;9(6)
Nutrients 2017 Jun 3;9(6)
Charge reversible calcium phosphate lipid hybrid nanoparticle for siRNA delivery.
Cai RQ, Liu DZ, Cui H, Cheng Y, Liu M, Zhang BL, Mei QB, Zhou SY
Oncotarget 2017 Jun 27;8(26):42772-42788
Oncotarget 2017 Jun 27;8(26):42772-42788
MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma.
Fan YP, Liao JZ, Lu YQ, Tian DA, Ye F, Zhao PX, Xiang GY, Tang WX, He XX
Molecular therapy. Nucleic acids 2017 Jun 16;7:181-189
Molecular therapy. Nucleic acids 2017 Jun 16;7:181-189
Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway.
Liu J, Zhang Y, Chen L, Yu F, Li X, Dan Tao, Zhao J, Zhou S
Acta biochimica et biophysica Sinica 2017 Jun 1;49(6):479-486
Acta biochimica et biophysica Sinica 2017 Jun 1;49(6):479-486
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
Wang YJ, Yan J, Zou XL, Guo KJ, Zhao Y, Meng CY, Yin F, Guo L
Chemico-biological interactions 2017 Jun 1;271:39-47
Chemico-biological interactions 2017 Jun 1;271:39-47
DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-β1/Smad signaling pathway.
Li Y, Liu H, Liang Y, Peng P, Ma X, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:174-180
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:174-180
In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells.
Zhao H, Liu Q, Wang S, Dai F, Cheng X, Cheng X, Chen W, Zhang M, Chen D
Cancer medicine 2017 Jul;6(7):1698-1706
Cancer medicine 2017 Jul;6(7):1698-1706
Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.
Zhang J, Jiang Y, Zhao Y, Wang W, Xie Y, Wang H, Yang Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712444
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712444
Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells.
Wang X, Zheng N, Dong J, Wang X, Liu L, Huang J
The Journal of steroid biochemistry and molecular biology 2017 Jul;171:318-327
The Journal of steroid biochemistry and molecular biology 2017 Jul;171:318-327
Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury.
Gao XJ, Xie GN, Liu L, Fu ZJ, Zhang ZW, Teng LZ
Experimental and therapeutic medicine 2017 Jul;14(1):841-847
Experimental and therapeutic medicine 2017 Jul;14(1):841-847
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, Polin L, Dyson G, Taub JW, Mohammad RM, Azmi AS, Zhao L, Ge Y
Oncotarget 2017 Jul 4;8(27):44295-44311
Oncotarget 2017 Jul 4;8(27):44295-44311
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Liu L, Liu Y, Chen X, Wang M, Zhou Y, Zhou P, Li W, Zhu F
Oncotarget 2017 Jul 4;8(27):43990-44003
Oncotarget 2017 Jul 4;8(27):43990-44003
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Maryam A, Mehmood T, Zhang H, Li Y, Khan M, Ma T
Scientific reports 2017 Jul 24;7(1):6242
Scientific reports 2017 Jul 24;7(1):6242
Hypertonic saline infusion suppresses apoptosis of hippocampal cells in a rat model of cardiopulmonary resuscitation.
Zhou X, Liu Y, Huang Y, Zhu S, Zhu J, Wang R
Scientific reports 2017 Jul 19;7(1):5783
Scientific reports 2017 Jul 19;7(1):5783
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
Su WC, Lin YF, Yu XP, Wang YX, Lin XD, Su QZ, Shen DY, Chen QX
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.
Wang EX, Zou BY, Shi L, Du LY, Zhu YY, Jiang YM, Ma XD, Kang XH, Wang CY, Zhen YH, Sun LD
Life sciences 2017 Jul 1;180:102-113
Life sciences 2017 Jul 1;180:102-113
Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury.
Gu YH, Wang Y, Bai Y, Liu M, Wang HL
Environmental toxicology and pharmacology 2017 Jan;49:194-201
Environmental toxicology and pharmacology 2017 Jan;49:194-201
Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats.
Wang Q, Dai P, Bao H, Liang P, Wang W, Xing A, Sun J
Experimental and therapeutic medicine 2017 Jan;13(1):263-268
Experimental and therapeutic medicine 2017 Jan;13(1):263-268
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G, Miao J, Zhao B
Oncotarget 2017 Jan 31;8(5):7625-7636
Oncotarget 2017 Jan 31;8(5):7625-7636
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction.
Mehmood T, Maryam A, Zhang H, Li Y, Khan M, Ma T
BioFactors (Oxford, England) 2017 Jan 2;43(1):63-72
BioFactors (Oxford, England) 2017 Jan 2;43(1):63-72
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Sun H, He X, Liu C, Li L, Zhou R, Jin T, Yue S, Feng D, Gong J, Sun J, Ji J, Xiang L
ACS chemical neuroscience 2017 Jan 18;8(1):155-164
ACS chemical neuroscience 2017 Jan 18;8(1):155-164
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
Li H, Lu Y, Pang Y, Li M, Cheng X, Chen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
Zhang L, Ma J, Jin X, Jia G, Jiang Y, Li C
Neurochemical research 2017 Feb;42(2):644-655
Neurochemical research 2017 Feb;42(2):644-655
Role of tRNA selenocysteine 1 associated protein 1 in the proliferation and apoptosis of cardiomyocyte‑like H9c2 cells.
Li MD, Cheng WP, Shi MX, Ge TD, Zheng XL, Wu DY, Hu XY, Luo JC, Li FL, Li H
Molecular medicine reports 2017 Feb;15(2):988-994
Molecular medicine reports 2017 Feb;15(2):988-994
Triggering of apoptosis in osteosarcoma cells by graphene/single-walled carbon nanotube hybrids via the ROS-mediated mitochondrial pathway.
Yan X, Yang W, Shao Z, Yang S, Liu X
Journal of biomedical materials research. Part A 2017 Feb;105(2):443-453
Journal of biomedical materials research. Part A 2017 Feb;105(2):443-453
Targeted breast cancer therapy by harnessing the inherent blood group antigen immune system.
Han W, Li W, Zhang X, Du Z, Liu X, Zhao X, Wen X, Wang G, Hu JF, Cui J
Oncotarget 2017 Feb 28;8(9):15034-15046
Oncotarget 2017 Feb 28;8(9):15034-15046
Propylene Glycol Alginate Sodium Sulfate Alleviates Cerulein-Induced Acute Pancreatitis by Modulating the MEK/ERK Pathway in Mice.
Zhang H, Li Y, Li L, Liu H, Hu L, Dai Y, Chen J, Xu S, Chen W, Xu X, Xu X
Marine drugs 2017 Feb 17;15(2)
Marine drugs 2017 Feb 17;15(2)
Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis.
Liu Y, Pu Y, Li D, Zhou L, Wan L
Life sciences 2017 Feb 1;170:1-8
Life sciences 2017 Feb 1;170:1-8
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378
Cell biology international 2017 Dec;41(12):1367-1378
Doxepin Mitigates Noise-induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway.
Su YT, Meng XX, Zhang X, Guo YB, Zhang HJ, Cheng YP, Xie XP, Chang YM, Bao JX
Anatomical record (Hoboken, N.J. : 2007) 2017 Dec;300(12):2220-2232
Anatomical record (Hoboken, N.J. : 2007) 2017 Dec;300(12):2220-2232
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, Zhao Y, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497
Chemosphere 2017 Dec;189:489-497
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
Chen YD, Zhang Y, Dong TX, Xu YT, Zhang W, An TT, Liu PF, Yang XH
Molecular medicine reports 2017 Dec;16(6):9401-9408
Molecular medicine reports 2017 Dec;16(6):9401-9408
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Liu M, Liu S, Tan W, Tang F, Long J, Li Z, Liang B, Chu C, Yang J
Molecular medicine reports 2017 Dec;16(6):8953-8963
Molecular medicine reports 2017 Dec;16(6):8953-8963
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Duan H, Wang R, Yan X, Liu H, Zhang Y, Mu D, Han J, Li X
Oncology letters 2017 Dec;14(6):6763-6768
Oncology letters 2017 Dec;14(6):6763-6768
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
Gu YP, Yang XM, Duan ZH, Luo P, Shang JH, Xiao W, Tao YX, Zhang DY, Zhang YB, Liu HZ
Experimental and therapeutic medicine 2017 Dec;14(6):5889-5895
Experimental and therapeutic medicine 2017 Dec;14(6):5889-5895
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
Autologous Adipose-Derived Stem Cells Reduce Burn-Induced Neuropathic Pain in a Rat Model.
Lin CH, Wu SH, Lee SS, Lin YN, Kuo YR, Chai CY, Huang SH
International journal of molecular sciences 2017 Dec 22;19(1)
International journal of molecular sciences 2017 Dec 22;19(1)
BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cells.
Fu X, Xu L, Qi L, Tian H, Yi D, Yu Y, Liu S, Li S, Xu Y, Wang C
Oncology reports 2017 Aug;38(2):859-865
Oncology reports 2017 Aug;38(2):859-865
The Effect of Selenium on the Cd-Induced Apoptosis via NO-Mediated Mitochondrial Apoptosis Pathway in Chicken Liver.
Zhang R, Yi R, Bi Y, Xing L, Bao J, Li J
Biological trace element research 2017 Aug;178(2):310-319
Biological trace element research 2017 Aug;178(2):310-319
Treatment mechanism of matrine in combination with irinotecan for colon cancer.
Duan L, Deng L, Wang D, Ma S, Li C, Zhao D
Oncology letters 2017 Aug;14(2):2300-2304
Oncology letters 2017 Aug;14(2):2300-2304
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fas and caspase-3.
Sun C, Liu H, Guo J, Yu Y, Yang D, He F, Du Z
Scientific reports 2017 Aug 7;7(1):7460
Scientific reports 2017 Aug 7;7(1):7460
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.
Zou Y, Qiu G, Jiang L, Cai Z, Sun W, Hu H, Lu C, Jin W, Hu G
Oncotarget 2017 Aug 29;8(35):58231-58246
Oncotarget 2017 Aug 29;8(35):58231-58246
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Xue X, Zhang J, Lan H, Xu Y, Wang H
Scientific reports 2017 Aug 2;7(1):7116
Scientific reports 2017 Aug 2;7(1):7116
Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats.
Zhao WY, Chen SB, Wang JJ, Xu C, Zhao ML, Dong HJ, Liang HQ, Li XH, Tu Y, Zhang S, Chen C, Sun HT
Brain research 2017 Aug 15;1669:141-149
Brain research 2017 Aug 15;1669:141-149
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
Epigallocatechin-3-gallate inhibits H(2)O(2)-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Yan X, Li Y, Yu H, Wang W, Wu C, Yang Y, Hu Y, Shi X, Li J
Scientific reports 2017 Aug 10;7(1):7774
Scientific reports 2017 Aug 10;7(1):7774
Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.
Xu W, Li F, Xu Z, Sun B, Cao J, Liu Y
Chemico-biological interactions 2017 Aug 1;273:28-36
Chemico-biological interactions 2017 Aug 1;273:28-36
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis.
Xu W, Zhu Q, Zhang B, Liu S, Dai X, Gao C, Gao L, Cui Y
Aging 2017 Apr;9(4):1269-1279
Aging 2017 Apr;9(4):1269-1279
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
He J, Shi J, Zhang K, Xue J, Li J, Yang J, Chen J, Wei J, Ren H, Liu X
Molecular medicine reports 2017 Apr;15(4):1693-1701
Molecular medicine reports 2017 Apr;15(4):1693-1701
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.
Chen Y, Yu S, Zhang N, Li Y, Chen S, Chang Y, Sun G, Sun Y
Biochemical and biophysical research communications 2017 Apr 29;486(2):423-430
Biochemical and biophysical research communications 2017 Apr 29;486(2):423-430
Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53.
Yao C, Cao X, Fu Z, Tian J, Dong W, Xu J, An K, Zhai L, Yu J
Medical science monitor : international medical journal of experimental and clinical research 2017 Apr 29;23:2059-2064
Medical science monitor : international medical journal of experimental and clinical research 2017 Apr 29;23:2059-2064
The mir-675-5p regulates the progression and development of pancreatic cancer via the UBQLN1-ZEB1-mir200 axis.
Wang J, Zhang Y, Wei H, Zhang X, Wu Y, Gong A, Xia Y, Wang W, Xu M
Oncotarget 2017 Apr 11;8(15):24978-24987
Oncotarget 2017 Apr 11;8(15):24978-24987
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Zhang XQ, Dong JJ, Cai T, Shen X, Zhou XJ, Liao L
Oncotarget 2017 Apr 11;8(15):24119-24129
Oncotarget 2017 Apr 11;8(15):24119-24129
Lobaplatin for the treatment of SK-MES-1 lung squamous cell line in vitro and in vivo.
Zhang H, Chen R, Yang S, Liu W, Li K, Zhang H, Zhu X, Chen B
OncoTargets and therapy 2016;9:4215-24
OncoTargets and therapy 2016;9:4215-24
Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811.
Li SH, Dong WC, Fan L, Wang GS
American journal of translational research 2016;8(9):3812-3821
American journal of translational research 2016;8(9):3812-3821
Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC.
Liu L, Zhao X, Zou H, Bai R, Yang K, Tian Z
Frontiers in physiology 2016;7:420
Frontiers in physiology 2016;7:420
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
Mycobacterium bovis Induces Endoplasmic Reticulum Stress Mediated-Apoptosis by Activating IRF3 in a Murine Macrophage Cell Line.
Cui Y, Zhao D, Sreevatsan S, Liu C, Yang W, Song Z, Yang L, Barrow P, Zhou X
Frontiers in cellular and infection microbiology 2016;6:182
Frontiers in cellular and infection microbiology 2016;6:182
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y, Bi B
SpringerPlus 2016;5:235
SpringerPlus 2016;5:235
Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis.
Wang J, Zhuo Y, Yin L, Wang H, Jiang Y, Liu X, Zhang M, Du F, Xia S, Shao Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38(2):449-60
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38(2):449-60
ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
Zhou Y, Zhang S, Deng S, Dai C, Tang S, Yang X, Li D, Zhao K, Xiao X
Toxicology mechanisms and methods 2016;26(1):11-21
Toxicology mechanisms and methods 2016;26(1):11-21
The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin.
Zeng J, Song F, Yang Y, Ma C, Deng G, Li Y, Wang Y, Liu X
Journal of immunology research 2016;2016:5708468
Journal of immunology research 2016;2016:5708468
Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway.
Yang J, Zhang K, Wu J, Shi J, Xue J, Li J, Chen J, Zhu Y, Wei J, He J, Liu X
Stem cells international 2016;2016:1690896
Stem cells international 2016;2016:1690896
Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK.
Zhang J, Xia Y, Xu Z, Deng X
Oxidative medicine and cellular longevity 2016;2016:1518738
Oxidative medicine and cellular longevity 2016;2016:1518738
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Duan F, Yu Y, Guan R, Xu Z, Liang H, Hong L
PloS one 2016;11(8):e0161886
PloS one 2016;11(8):e0161886
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells.
Wu L, Bao K, Song R, Wang D, Zhang L, Wang W, Zhang W, Bin W
PloS one 2016;11(7):e0159503
PloS one 2016;11(7):e0159503
OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Models.
Wang J, Chen X, Wang F, Zhang J, Li P, Li Z, Xu J, Gao F, Jin C, Tian H, Zhang J, Li W, Lu L, Xu GT
PloS one 2016;11(5):e0155860
PloS one 2016;11(5):e0155860
Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.
Li H, Zheng L, Mo Y, Gong Q, Jiang A, Zhao J
PloS one 2016;11(12):e0167908
PloS one 2016;11(12):e0167908
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Dai C, Tang S, Velkov T, Xiao X
Molecular neurobiology 2016 Sep;53(7):4685-700
Molecular neurobiology 2016 Sep;53(7):4685-700
Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction.
Li D, Dai C, Zhou Y, Yang X, Zhao K, Xiao X, Tang S
Environmental toxicology and pharmacology 2016 Sep;46:140-146
Environmental toxicology and pharmacology 2016 Sep;46:140-146
Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice.
Xu X, Gou L, Zhou M, Yang F, Zhao Y, Feng T, Shi P, Ghavamian A, Zhao W, Yu Y, Lu Y, Yi F, Liu G, Tang W
International immunopharmacology 2016 Sep;38:409-19
International immunopharmacology 2016 Sep;38:409-19
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY
Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
Dopaminergic neuron-specific deletion of p53 gene is neuroprotective in an experimental Parkinson's disease model.
Qi X, Davis B, Chiang YH, Filichia E, Barnett A, Greig NH, Hoffer B, Luo Y
Journal of neurochemistry 2016 Sep;138(5):746-57
Journal of neurochemistry 2016 Sep;138(5):746-57
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Han X, Li W, Huang D, Yang X
Chemico-biological interactions 2016 Sep 25;257:132-40
Chemico-biological interactions 2016 Sep 25;257:132-40
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
Zhang Z, Li HM, Zhou C, Li Q, Ma L, Zhang Z, Sun Y, Wang L, Zhang X, Zhu B, Hong YS, Wu CZ, Liu H
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
Dia VP, Krishnan HB
Scientific reports 2016 Sep 15;6:33532
Scientific reports 2016 Sep 15;6:33532
Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP.
Filichia E, Hoffer B, Qi X, Luo Y
Scientific reports 2016 Sep 13;6:32656
Scientific reports 2016 Sep 13;6:32656
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
Gamallat Y, Meyiah A, Kuugbee ED, Hago AM, Chiwala G, Awadasseid A, Bamba D, Zhang X, Shang X, Luo F, Xin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
47kDa isoform of Annexin A7 affecting the apoptosis of mouse hepatocarcinoma cells line.
Bai L, Guo Y, Du Y, Wang H, Zhao Z, Huang Y, Tang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:1127-1131
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:1127-1131
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
Zhao Y, Zhang B, Lei Y, Sun J, Zhang Y, Yang S, Zhang X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma.
Ye M, Wu Q, Zhang M, Huang J
Molecular medicine reports 2016 Oct;14(4):2953-8
Molecular medicine reports 2016 Oct;14(4):2953-8
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Oncology letters 2016 Oct;12(4):2632-2640
Oncology letters 2016 Oct;12(4):2632-2640
Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.
Tang D, Wang C, Gao Y, Pu J, Long J, Xu W
Neuroscience letters 2016 Oct 6;632:79-85
Neuroscience letters 2016 Oct 6;632:79-85
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
Wang S, Xu H, Xin Y, Li M, Fu W, Wang Y, Lu Z, Yu X, Sui D
European journal of pharmacology 2016 Oct 5;788:335-342
European journal of pharmacology 2016 Oct 5;788:335-342
Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance.
Zhao Y, Huan ML, Liu M, Cheng Y, Sun Y, Cui H, Liu DZ, Mei QB, Zhou SY
Scientific reports 2016 Oct 12;6:35267
Scientific reports 2016 Oct 12;6:35267
Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma.
Liu T, Wang G, Tao H, Yang Z, Wang Y, Meng Z, Cao R, Xiao Y, Wang X, Zhou J
BMC cancer 2016 Oct 12;16(1):790
BMC cancer 2016 Oct 12;16(1):790
Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway.
Zhang X, Song S, Luo H
Medicine 2016 Nov;95(44):e5050
Medicine 2016 Nov;95(44):e5050
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.
Song Z, Chen CP, Liu J, Wen X, Sun H, Yuan H
European journal of medicinal chemistry 2016 Nov 29;124:809-819
European journal of medicinal chemistry 2016 Nov 29;124:809-819
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Liu W, Ning R, Chen RN, Huang XF, Dai QS, Hu JH, Wang YW, Wu LL, Xiong J, Hu G, Guo QL, Yang J, Wang H
Molecular carcinogenesis 2016 May;55(5):440-57
Molecular carcinogenesis 2016 May;55(5):440-57
Triazole fungicide tebuconazole disrupts human placental trophoblast cell functions.
Zhou J, Zhang J, Li F, Liu J
Journal of hazardous materials 2016 May 5;308:294-302
Journal of hazardous materials 2016 May 5;308:294-302
The role of RhoA in vulvar squamous cell carcinoma: a carcinogenesis, progression, and target therapy marker.
Wang J, Wu Q, Zhang LH, Zhao YX, Wu X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Mar;37(3):2879-90
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Mar;37(3):2879-90
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
Aziz F, Wang X, Liu J, Yan Q
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
β-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-κB Signaling Pathway.
Zhu X, Zhang Y, Li Q, Yang L, Zhang N, Ma S, Zhang K, Song J, Guan F
Journal of biochemical and molecular toxicology 2016 Mar;30(3):148-57
Journal of biochemical and molecular toxicology 2016 Mar;30(3):148-57
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Sun Z, Lan X, Ahsan A, Xi Y, Liu S, Zhang Z, Chu P, Song Y, Piao F, Peng J, Lin Y, Han G, Tang Z
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.
Yu Y, Xu X, Liu L, Mao S, Feng T, Lu Y, Cheng Y, Wang H, Zhao W, Tang W
Journal of cellular and molecular medicine 2016 Mar;20(3):506-17
Journal of cellular and molecular medicine 2016 Mar;20(3):506-17
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Lei X, Cui K, Li Z, Su J, Jiang J, Zhang H, Liu Q, Shi D
Theriogenology 2016 Mar 15;85(5):999-1012
Theriogenology 2016 Mar 15;85(5):999-1012
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Li X, Song Y, Zhang P, Zhu H, Chen L, Xiao Y, Xing Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Suppression of SOX18 by siRNA inhibits cell growth and invasion of breast cancer cells.
Zhang J, Ma Y, Wang S, Chen F, Gu Y
Oncology reports 2016 Jun;35(6):3721-7
Oncology reports 2016 Jun;35(6):3721-7
Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.
Guo X, Zhu D, Lian R, Han Y, Guo Y, Li Z, Tang S, Chen J
Experimental eye research 2016 Jun;147:37-49
Experimental eye research 2016 Jun;147:37-49
Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats.
Zhu XY, Ma PS, Wu W, Zhou R, Hao YJ, Niu Y, Sun T, Li YX, Yu JQ
Brain research bulletin 2016 Jun;124:295-305
Brain research bulletin 2016 Jun;124:295-305
Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.
Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su H, Li P, Wan JB, He C
Scientific reports 2016 Jun 6;6:26064
Scientific reports 2016 Jun 6;6:26064
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase.
Zhang Y, Chen Z, Wang T, Yang J, Li R, Wang S, Liu J, Ye Z
Oncotarget 2016 Jun 28;7(26):39302-39315
Oncotarget 2016 Jun 28;7(26):39302-39315
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Zhao S, Cao Y, Liu SB, Wang XA, Bao RF, Shu YJ, Hu YP, Zhang YJ, Jiang L, Zhang F, Liang HB, Li HF, Ma Q, Xu Y, Wang Z, Zhang YC, Chen L, Zhou J, Liu YB
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.
Wang J, Wan X, Gao Y, Zhong M, Sha L, Liu B, Zhang W, Tian L, Ruan W, Cao S, Huang M
Oncology reports 2016 Jul;36(1):441-7
Oncology reports 2016 Jul;36(1):441-7
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Liu HZ, Tao YX, Luo P, Deng CM, Gu YP, Yang L, Zhong JP
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Zhang XF, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Wang DD, Jiang SS, Zheng HX, Lv L, Chen CL, Zhang HX, Xia JC
Molecular carcinogenesis 2016 Jan;55(1):64-76
Molecular carcinogenesis 2016 Jan;55(1):64-76
Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway.
Wang C, Li T, Tang S, Zhao D, Zhang C, Zhang S, Deng S, Zhou Y, Xiao X
Environmental toxicology and pharmacology 2016 Jan;41:167-79
Environmental toxicology and pharmacology 2016 Jan;41:167-79
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
Zhao C, Su G, Wang X, Zhang X, Guo S, Zhao Y
Biotechnology letters 2016 Jan;38(1):43-50
Biotechnology letters 2016 Jan;38(1):43-50
The Role of the Y Box Binding Protein 1 C-Terminal Domain in Vascular Endothelial Cell Proliferation, Apoptosis, and Angiogenesis.
Wang W, Wang HJ, Wang B, Li Y, Qin Y, Zheng LS, Zhou JS, Qu PH, Shi JH, Zhang HS
DNA and cell biology 2016 Jan;35(1):24-32
DNA and cell biology 2016 Jan;35(1):24-32
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Radiation research 2016 Jan;185(1):77-86
Radiation research 2016 Jan;185(1):77-86
Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer.
Jin G, Lan Y, Han F, Sun Y, Liu Z, Zhang M, Liu X, Zhang X, Hu J, Liu H, Wang B
Molecular medicine reports 2016 Jan;13(1):359-66
Molecular medicine reports 2016 Jan;13(1):359-66
Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J
Oncology letters 2016 Jan;11(1):182-188
Oncology letters 2016 Jan;11(1):182-188
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
Jiang SH, Wang Y, Yang JY, Li J, Feng MX, Wang YH, Yang XM, He P, Tian GA, Zhang XX, Li Q, Cao XY, Huo YM, Yang MW, Fu XL, Li J, Liu DJ, Dai M, Wen SY, Gu JR, Hong J, Hua R, Zhang ZG, Sun YW
Oncotarget 2016 Jan 26;7(4):4226-40
Oncotarget 2016 Jan 26;7(4):4226-40
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.
Tang N, Shi L, Yu Z, Dong P, Wang C, Huo X, Zhang B, Huang S, Deng S, Liu K, Ma T, Wang X, Wu L, Ma XC
Oncotarget 2016 Jan 19;7(3):3533-47
Oncotarget 2016 Jan 19;7(3):3533-47
Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.
Lei X, Cui K, Liu Q, Zhang H, Li Z, Huang B, Shi D
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84
Effects of induced pluripotent stem cells-derived conditioned medium on the proliferation and anti-apoptosis of human adipose-derived stem cells.
Lian RL, Guo XL, Chen JS, Guo YL, Zheng JF, Chen YW
Molecular and cellular biochemistry 2016 Feb;413(1-2):69-85
Molecular and cellular biochemistry 2016 Feb;413(1-2):69-85
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su H, Wang Y, Mei Z, He C
BMC complementary and alternative medicine 2016 Feb 9;16:58
BMC complementary and alternative medicine 2016 Feb 9;16:58
The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.
Sun G, Ye N, Dai D, Chen Y, Li C, Sun Y
International journal of molecular sciences 2016 Feb 23;17(3):267
International journal of molecular sciences 2016 Feb 23;17(3):267
Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
Wang Y, Chen CL, Pan QZ, Wu YY, Zhao JJ, Jiang SS, Chao J, Zhang XF, Zhang HX, Zhou ZQ, Tang Y, Huang XQ, Zhang JH, Xia JC
Oncotarget 2016 Feb 2;7(5):6323-34
Oncotarget 2016 Feb 2;7(5):6323-34
MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α.
Chen S, Sun KX, Liu BL, Zong ZH, Zhao Y
Molecular cancer 2016 Feb 2;15:11
Molecular cancer 2016 Feb 2;15:11
KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.
Li X, He Y, Xu Y, Huang X, Liu J, Xie M, Liu X
American journal of physiology. Lung cellular and molecular physiology 2016 Feb 15;310(4):L299-310
American journal of physiology. Lung cellular and molecular physiology 2016 Feb 15;310(4):L299-310
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
Zhao L, Wen Q, Yang G, Huang Z, Shen T, Li H, Ren D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H, Zhang J, Ye Q
Scientific reports 2016 Feb 12;6:21010
Scientific reports 2016 Feb 12;6:21010
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y, Sun L
International journal of oncology 2016 Dec;49(6):2507-2519
International journal of oncology 2016 Dec;49(6):2507-2519
Naringin protects against lipopolysaccharide-induced cardiac injury in mice.
Xianchu L, Lan PZ, Qiufang L, Yi L, Xiangcheng R, Wenqi H, Yang D
Environmental toxicology and pharmacology 2016 Dec;48:1-6
Environmental toxicology and pharmacology 2016 Dec;48:1-6
Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells.
Zhang J, Ding YR, Wang R
Acta pharmacologica Sinica 2016 Dec;37(12):1534-1542
Acta pharmacologica Sinica 2016 Dec;37(12):1534-1542
Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats.
Chen J, Zhang HF, Xiong CM, Ruan JL
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2016 Dec;36(6):806-810
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2016 Dec;36(6):806-810
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
Wu JF, Ji J, Dong SY, Li BB, Yu ML, Wu DD, Tao L, Tong XH
Oncology reports 2016 Dec;36(6):3251-3258
Oncology reports 2016 Dec;36(6):3251-3258
PACE4 regulates apoptosis in human pancreatic cancer Panc‑1 cells via the mitochondrial signaling pathway.
Tian XF, Huang GM, Zang HL, Cao H
Molecular medicine reports 2016 Dec;14(6):5205-5210
Molecular medicine reports 2016 Dec;14(6):5205-5210
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Jiang G, Liu J, Ren B, Tang Y, Owusu L, Li M, Zhang J, Liu L, Li W
Journal of ethnopharmacology 2016 Dec 4;193:368-376
Journal of ethnopharmacology 2016 Dec 4;193:368-376
Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.
Zhang W, Kang M, Zhang T, Li B, Liao X, Wang R
International journal of molecular sciences 2016 Dec 19;17(12)
International journal of molecular sciences 2016 Dec 19;17(12)
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
Zhang G, Xu M, Zhang H, Song Y, Wang J, Zhang C
Toxicology and applied pharmacology 2016 Dec 15;313:1-9
Toxicology and applied pharmacology 2016 Dec 15;313:1-9
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, Li Y, Bao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Ju D, Yamaguchi F, Zhan G, Higuchi T, Asakura T, Morita A, Orimo H, Hu S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.
Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, Cao F, Sun X, Chen L, Vitek MP, Jiang Y
Oncotarget 2016 Aug 30;7(35):56030-56044
Oncotarget 2016 Aug 30;7(35):56030-56044
Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.
Jing H, Sun W, Fan J, Zhang Y, Yang J, Jia J, Li J, Guo J, Luo S, Zheng Y
Molecular medicine reports 2016 Apr;13(4):3009-16
Molecular medicine reports 2016 Apr;13(4):3009-16
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
Xia ZX, Li ZX, Zhang M, Sun LM, Zhang QF, Qiu XS
Experimental and molecular pathology 2016 Apr;100(2):353-60
Experimental and molecular pathology 2016 Apr;100(2):353-60
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways.
Tang R, Xu X, Yang W, Yu W, Hou S, Xuan Y, Tang Z, Zhao S, Chen Y, Xiao X, Huang W, Guo W, Li M, Deng W
Cancer letters 2016 Apr 1;373(1):77-87
Cancer letters 2016 Apr 1;373(1):77-87
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23
Drug design, development and therapy 2015;9:5911-23
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
Piao MX, Bai JW, Zhang PF, Zhang YZ
International journal of clinical and experimental pathology 2015;8(3):2787-94
International journal of clinical and experimental pathology 2015;8(3):2787-94
MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction.
Shao Q, Jiang W, Jin Y
International journal of clinical and experimental pathology 2015;8(11):14465-71
International journal of clinical and experimental pathology 2015;8(11):14465-71
Level of circulated microRNA-421 in gastric carcinoma and related mechanisms.
Zhao G, Xu L, Hui L, Zhao J
International journal of clinical and experimental pathology 2015;8(11):14252-6
International journal of clinical and experimental pathology 2015;8(11):14252-6
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
Wang B, Zhao MZ, Cui NP, Lin DD, Zhang AY, Qin Y, Liu CY, Yan WT, Shi JH, Chen BP
FEBS open bio 2015;5:147-54
FEBS open bio 2015;5:147-54
Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord.
Huang SH, Wu SH, Lee SS, Chang KP, Chai CY, Yeh JL, Lin SD, Kwan AL, David Wang HM, Lai CS
PloS one 2015;10(9):e0137563
PloS one 2015;10(9):e0137563
A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.
Wang Z, Zhao Z, Lu J, Chen Z, Mao A, Teng G, Liu F
PloS one 2015;10(8):e0133728
PloS one 2015;10(8):e0133728
Cytotoxicity of various types of gold-mesoporous silica nanoparticles in human breast cancer cells.
Liu G, Li Q, Ni W, Zhang N, Zheng X, Wang Y, Shao D, Tai G
International journal of nanomedicine 2015;10:6075-87
International journal of nanomedicine 2015;10:6075-87
Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells.
Yao XF, Zheng BL, Bai J, Jiang LP, Zheng Y, Qi BX, Geng CY, Zhong LF, Yang G, Chen M, Liu XF, Sun XC
Environmental toxicology and pharmacology 2015 Sep;40(2):486-91
Environmental toxicology and pharmacology 2015 Sep;40(2):486-91
Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice.
Zhao P, Zhou R, Zhu XY, Hao YJ, Li N, Wang J, Niu Y, Sun T, Li YX, Yu JQ
International journal of molecular medicine 2015 Sep;36(3):633-44
International journal of molecular medicine 2015 Sep;36(3):633-44
Lithium chloride administration prevents spatial learning and memory impairment in repeated cerebral ischemia-reperfusion mice by depressing apoptosis and increasing BDNF expression in hippocampus.
Fan M, Jin W, Zhao H, Xiao Y, Jia Y, Yin Y, Jiang X, Xu J, Meng N, Lv P
Behavioural brain research 2015 Sep 15;291:399-406
Behavioural brain research 2015 Sep 15;291:399-406
Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death.
Zhao P, Zhou R, Li HN, Yao WX, Qiao HQ, Wang SJ, Niu Y, Sun T, Li YX, Yu JQ
Neurochemistry international 2015 Oct;89:17-27
Neurochemistry international 2015 Oct;89:17-27
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
Zhao S, Li H, Jiang C, Ma T, Wu C, Huo Q, Liu H
Journal of bioenergetics and biomembranes 2015 Oct;47(5):373-81
Journal of bioenergetics and biomembranes 2015 Oct;47(5):373-81
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Zhang HX, Jiang SS, Zhang XF, Zhou ZQ, Pan QZ, Chen CL, Zhao JJ, Tang Y, Xia JC, Weng DS
Oncotarget 2015 Oct 27;6(33):34800-17
Oncotarget 2015 Oct 27;6(33):34800-17
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
Yuan H, Wang J, Wang F, Zhang N, Li Q, Xie F, Chen T, Zhai R, Wang F, Guo Y, Ni W, Tai G
Molecular medicine reports 2015 Nov;12(5):6782-8
Molecular medicine reports 2015 Nov;12(5):6782-8
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
He Y, Cao X, Liu X, Li X, Xu Y, Liu J, Shi J
Experimental cell research 2015 Nov 15;339(1):122-34
Experimental cell research 2015 Nov 15;339(1):122-34
A Neuroprotective Sericin Hydrogel As an Effective Neuronal Cell Carrier for the Repair of Ischemic Stroke.
Wang Z, Wang J, Jin Y, Luo Z, Yang W, Xie H, Huang K, Wang L
ACS applied materials & interfaces 2015 Nov 11;7(44):24629-40
ACS applied materials & interfaces 2015 Nov 11;7(44):24629-40
Progranulin protects against renal ischemia/reperfusion injury in mice.
Zhou M, Tang W, Fu Y, Xu X, Wang Z, Lu Y, Liu F, Yang X, Wei X, Zhang Y, Liu J, Geng X, Zhang C, Wan Q, Li N, Yi F
Kidney international 2015 May;87(5):918-29
Kidney international 2015 May;87(5):918-29
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Jin Y, Cao B, Zhang M, Zhan Q, Herman JG, Yu M, Guo M
Genes & cancer 2015 May;6(5-6):231-40
Genes & cancer 2015 May;6(5-6):231-40
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Xie X, Zhang J, Chen D, Pan H, Wu Z, Ge D, Yang G
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis.
Liu S, Zhang XP, Han NN, Lv S, Xiong JY
Environmental toxicology and pharmacology 2015 May;39(3):1212-20
Environmental toxicology and pharmacology 2015 May;39(3):1212-20
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W
British journal of pharmacology 2015 May;172(9):2232-45
British journal of pharmacology 2015 May;172(9):2232-45
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Shi J, Ren C, Liu H, Wang L, Zhu B, Huang W, Liu W, Liu J, Liu Y, Xia X, Xu R, Jiang X
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway.
Huang Y, Du Y, Zhang X, Bai L, Mibrahim M, Zhang J, Wei Y, Li C, Fan S, Wang H, Zhao Z, Tang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:146-50
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:146-50
Enantioselective apoptosis induced by individual isomers of bifenthrin in Hep G2 cells.
Liu H, Li J
Environmental toxicology and pharmacology 2015 Mar;39(2):810-4
Environmental toxicology and pharmacology 2015 Mar;39(2):810-4
Knockdown of CkrL by shRNA deteriorates hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis and survival inhibition Via Bax and downregulation of P-Erk1/2.
Zhang ZS, Yang DY, Fu YB, Zhang L, Zhao QP, Li G
Cell biochemistry and function 2015 Mar;33(2):80-8
Cell biochemistry and function 2015 Mar;33(2):80-8
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
Gu Y, He Y, Zhang X, Shi Y, Yang Q, Yu L, Sun Z, Zhang H, Wang J, Gao X, Wang J
Molecular reproduction and development 2015 Jun;82(6):475-88
Molecular reproduction and development 2015 Jun;82(6):475-88
MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer.
Yang T, Thakur A, Chen T, Yang L, Lei G, Liang Y, Zhang S, Ren H, Chen M
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4357-65
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jun;36(6):4357-65
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice.
Shi Q, Song X, Fu J, Su C, Xia X, Song E, Song Y
International immunopharmacology 2015 Dec;29(2):722-729
International immunopharmacology 2015 Dec;29(2):722-729
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Gao L, Wang Y, Xu Z, Li X, Wu J, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
Ahsan A, Han G, Pan J, Liu S, Padhiar AA, Chu P, Sun Z, Zhang Z, Sun B, Wu J, Irshad A, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
Optimization of intrinsic and extrinsic tendon healing through controllable water-soluble mitomycin-C release from electrospun fibers by mediating adhesion-related gene expression.
Zhao X, Jiang S, Liu S, Chen S, Lin ZY, Pan G, He F, Li F, Fan C, Cui W
Biomaterials 2015 Aug;61:61-74
Biomaterials 2015 Aug;61:61-74
Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.
Sun Y, Liu Z, Zou X, Lan Y, Sun X, Wang X, Zhao S, Jiang C, Liu H
Journal of bioenergetics and biomembranes 2015 Aug;47(4):319-29
Journal of bioenergetics and biomembranes 2015 Aug;47(4):319-29
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW
International journal of oncology 2015 Aug;47(2):701-9
International journal of oncology 2015 Aug;47(2):701-9
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
Khan MN, Wang B, Wei J, Zhang Y, Li Q, Luan X, Cheng JW, Gordon JR, Li F, Liu H
Oncotarget 2015 Aug 28;6(25):21315-27
Oncotarget 2015 Aug 28;6(25):21315-27
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.
Wang T, Li Y, Wang Y, Zhou R, Ma L, Hao Y, Jin S, Du J, Zhao C, Sun T, Yu J
PloS one 2014;9(3):e90780
PloS one 2014;9(3):e90780
Lycium barbarum polysaccharides protect human lens epithelial cells against oxidative stress-induced apoptosis and senescence.
Qi B, Ji Q, Wen Y, Liu L, Guo X, Hou G, Wang G, Zhong J
PloS one 2014;9(10):e110275
PloS one 2014;9(10):e110275
PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.
Jiang SH, He P, Ma MZ, Wang Y, Li RK, Fang F, Fu Y, Tian GA, Qin WX, Zhang ZG
International journal of clinical and experimental pathology 2014;7(7):3827-35
International journal of clinical and experimental pathology 2014;7(7):3827-35
The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways.
Liu Y, He J, Chen X, Li J, Shen M, Yu W, Yang Y, Xiao Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;34(3):637-45
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;34(3):637-45
14-Thienyl methylene matrine (YYJ18), the derivative from matrine, induces apoptosis of human nasopharyngeal carcinoma cells by targeting MAPK and PI3K/Akt pathways in vitro.
Xie M, Yi X, Wang R, Wang L, He G, Zhu M, Qi C, Liu Y, Ye Y, Tan S, Tang A
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(5):1475-83
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(5):1475-83
The mitochondrial thioredoxin is required for liver development in zebrafish.
Zhang J, Cui X, Wang L, Liu F, Jiang T, Li C, Li D, Huang M, Liao S, Wang J, Chen J, Jia H, He J, Tang Z, Yin Z, Liu M
Current molecular medicine 2014;14(6):772-82
Current molecular medicine 2014;14(6):772-82
RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma.
Liang YY, Zheng LS, Wu YZ, Peng LX, Cao Y, Cao X, Xie P, Huang BJ, Qian CN
Cell cycle (Georgetown, Tex.) 2014;13(9):1440-9
Cell cycle (Georgetown, Tex.) 2014;13(9):1440-9
Lipoxin A4 methyl ester ameliorates cognitive deficits induced by chronic cerebral hypoperfusion through activating ERK/Nrf2 signaling pathway in rats.
Jin W, Jia Y, Huang L, Wang T, Wang H, Dong Y, Zhang H, Fan M, Lv P
Pharmacology, biochemistry, and behavior 2014 Sep;124:145-52
Pharmacology, biochemistry, and behavior 2014 Sep;124:145-52
Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis.
Xia X, Su C, Fu J, Zhang P, Jiang X, Xu D, Hu L, Song E, Song Y
International immunopharmacology 2014 Oct;22(2):293-302
International immunopharmacology 2014 Oct;22(2):293-302
13-acetoxysarcocrassolide induces apoptosis on human gastric carcinoma cells through mitochondria-related apoptotic pathways: p38/JNK activation and PI3K/AKT suppression.
Su CC, Chen JY, Din ZH, Su JH, Yang ZY, Chen YJ, Wang RY, Wu YJ
Marine drugs 2014 Oct 23;12(10):5295-315
Marine drugs 2014 Oct 23;12(10):5295-315
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats.
Zhang Y, Liu W, Zhou Y, Ma C, Li S, Cong B
Physiology & behavior 2014 May 28;131:41-8
Physiology & behavior 2014 May 28;131:41-8
Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.
Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X
International journal of molecular sciences 2014 May 22;15(5):9103-16
International journal of molecular sciences 2014 May 22;15(5):9103-16
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
Zhang Q, Zhang Y, Zhang P, Chao Z, Xia F, Jiang C, Zhang X, Jiang Z, Liu H
Genes & cancer 2014 Mar;5(3-4):100-12
Genes & cancer 2014 Mar;5(3-4):100-12
A caspase-dependent pathway is involved in Wnt/β-catenin signaling promoted apoptosis in Bacillus Calmette-Guerin infected RAW264.7 macrophages.
Wu X, Deng G, Hao X, Li Y, Zeng J, Ma C, He Y, Liu X, Wang Y
International journal of molecular sciences 2014 Mar 21;15(3):5045-62
International journal of molecular sciences 2014 Mar 21;15(3):5045-62
Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of lewis cells via RAGE/TLR4-dependent signal pathways.
Xu X, Zhu H, Wang T, Sun Y, Ni P, Liu Y, Tian S, Amoah Barnie P, Shen H, Xu W, Xu H, Su Z
Scandinavian journal of immunology 2014 Jun;79(6):386-94
Scandinavian journal of immunology 2014 Jun;79(6):386-94
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo.
Guo X, Sesaki H, Qi X
The Biochemical journal 2014 Jul 1;461(1):137-46
The Biochemical journal 2014 Jul 1;461(1):137-46
Daphnoretin-induced apoptosis in HeLa cells: a possible mitochondria-dependent pathway.
Yang ZY, Kan JT, Cheng ZY, Wang XL, Zhu YZ, Guo W
Cytotechnology 2014 Jan;66(1):51-61
Cytotechnology 2014 Jan;66(1):51-61
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Wang XM, Yao M, Liu SX, Hao J, Liu QJ, Gao F
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
Chen J, Li HM, Zhang XN, Xiong CM, Ruan JL
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Feb;34(1):125-130
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Feb;34(1):125-130
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
Zhu L, Luo Q, Bi J, Ding J, Ge S, Chen F
Chemico-biological interactions 2014 Dec 5;224:149-56
Chemico-biological interactions 2014 Dec 5;224:149-56
Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
Zhan Y, Chen Y, Liu R, Zhang H, Zhang Y
Archives of pharmacal research 2014 Aug;37(8):1086-95
Archives of pharmacal research 2014 Aug;37(8):1086-95
MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells.
Liu W, Xu C, Wan H, Liu C, Wen C, Lu H, Wan F
International journal of molecular medicine 2014 Aug;34(2):420-8
International journal of molecular medicine 2014 Aug;34(2):420-8
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Wang N, Zhang Y, Wu L, Wang Y, Cao Y, He L, Li X, Zhao J
Neuropharmacology 2014 Apr;79:282-9
Neuropharmacology 2014 Apr;79:282-9
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H, Gao QL
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Wei Y, Xu Y, Han X, Qi Y, Xu L, Xu Y, Yin L, Sun H, Liu K, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Sep;59:118-28
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Sep;59:118-28
The protective effect of Cold-inducible RNA-binding protein (CIRP) on testicular torsion/detorsion: an experimental study in mice.
Xia Z, Jiang K, Liu T, Zheng H, Liu X, Zheng X
Journal of pediatric surgery 2013 Oct;48(10):2140-7
Journal of pediatric surgery 2013 Oct;48(10):2140-7
Administration of cathepsin B inhibitor CA-074Me reduces inflammation and apoptosis in polymyositis.
Feng Y, Ni L, Wang Q
Journal of dermatological science 2013 Nov;72(2):158-67
Journal of dermatological science 2013 Nov;72(2):158-67
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu K, Sun CK
Neurochemistry international 2013 Nov;63(5):522-32
Neurochemistry international 2013 Nov;63(5):522-32
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
Hong Y, Zhou Y, Wang Y, Xiao S, Liao DJ, Zhao Q
Molecular biology reports 2013 Nov;40(11):6287-93
Molecular biology reports 2013 Nov;40(11):6287-93
Oxysophoridine protects against focal cerebral ischemic injury by inhibiting oxidative stress and apoptosis in mice.
Wang TF, Lei Z, Li YX, Wang YS, Wang J, Wang SJ, Hao YJ, Zhou R, Jin SJ, Du J, Li J, Sun T, Yu JQ
Neurochemical research 2013 Nov;38(11):2408-17
Neurochemical research 2013 Nov;38(11):2408-17
Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.
Wang Y, Xu YS, Yin LH, Xu LN, Peng JY, Zhou H, Kang W
Chemico-biological interactions 2013 Nov 25;206(2):346-55
Chemico-biological interactions 2013 Nov 25;206(2):346-55
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Gao F, Yao M, Shi Y, Hao J, Ren Y, Liu Q, Wang X, Duan H
Journal of cellular biochemistry 2013 May;114(5):1029-38
Journal of cellular biochemistry 2013 May;114(5):1029-38
MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer.
Yu SJ, Hu JY, Kuang XY, Luo JM, Hou YF, Di GH, Wu J, Shen ZZ, Song HY, Shao ZM
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 15;19(6):1389-99
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Mar 15;19(6):1389-99
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Zhang J, Sun Q, Zhang Z, Ge S, Han ZG, Chen WT
Oncogene 2013 Jan 3;32(1):61-9
Oncogene 2013 Jan 3;32(1):61-9
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.
Zhang C, Wang C, Tang S, Sun Y, Zhao D, Zhang S, Deng S, Zhou Y, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:825-38
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:825-38
Neuroprotective effect of Danshensu derivatives as anti-ischaemia agents on SH-SY5Y cells and rat brain.
Seetapun S, Yaoling J, Wang Y, Zhu YZ
Bioscience reports 2013 Aug 30;33(4)
Bioscience reports 2013 Aug 30;33(4)
The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.
Jia Y, Dong X, Zhou P, Liu X, Pan L, Xin H, Zhu YZ, Wang Y
European journal of medicinal chemistry 2012 Sep;55:176-87
European journal of medicinal chemistry 2012 Sep;55:176-87
Alantolactone induces activation of apoptosis in human hepatoma cells.
Lei JC, Yu JQ, Yin Y, Liu YW, Zou GL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Jia Y, Ji L, Zhang S, Xu L, Yin L, Li L, Zhao Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism.
Liu W, Zhang Y, Hao J, Liu S, Liu Q, Zhao S, Shi Y, Duan H
Journal of cellular biochemistry 2012 Oct;113(10):3186-96
Journal of cellular biochemistry 2012 Oct;113(10):3186-96
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.
Zhao X, Cong X, Zheng L, Xu L, Yin L, Peng J
Toxicology letters 2012 Oct 2;214(1):69-80
Toxicology letters 2012 Oct 2;214(1):69-80
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.
Gong K, Chen C, Zhan Y, Chen Y, Huang Z, Li W
The Journal of biological chemistry 2012 Oct 12;287(42):35576-35588
The Journal of biological chemistry 2012 Oct 12;287(42):35576-35588
The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion.
Zeng R, He J, Peng J, Chen Y, Yi S, Zhao F, Cui G
Annals of hematology 2012 Mar;91(3):407-17
Annals of hematology 2012 Mar;91(3):407-17
Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.
Ding F, Shao ZW, Yang SH, Wu Q, Gao F, Xiong LM
Apoptosis : an international journal on programmed cell death 2012 Jun;17(6):579-90
Apoptosis : an international journal on programmed cell death 2012 Jun;17(6):579-90
Involvement of GPR12 in the regulation of cell proliferation and survival.
Lu X, Zhang N, Meng B, Dong S, Hu Y
Molecular and cellular biochemistry 2012 Jul;366(1-2):101-10
Molecular and cellular biochemistry 2012 Jul;366(1-2):101-10
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Yin Y, Chen W, Tang C, Ding H, Jang J, Weng M, Cai Y, Zou G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes.
Liu H, Liu J, Xu L, Zhou S, Li L, Liu W
Toxicology 2010 Oct 9;276(2):115-21
Toxicology 2010 Oct 9;276(2):115-21
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
Chen W, Hou J, Yin Y, Jang J, Zheng Z, Fan H, Zou G
Biochemical pharmacology 2010 Jul 15;80(2):247-54
Biochemical pharmacology 2010 Jul 15;80(2):247-54
rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure.
Hu J, Yan D, Gao J, Xu C, Yuan Y, Zhu R, Xiang D, Weng S, Han W, Zang G, Yu Y
Laboratory investigation; a journal of technical methods and pathology 2010 Dec;90(12):1737-46
Laboratory investigation; a journal of technical methods and pathology 2010 Dec;90(12):1737-46
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 50599-2-Ig(BAX antibody) at dilution of 1:2000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BAX antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BAX. This antibody recognizes human, mouse, rat antigen. The BAX antibody has been validated for the following applications: ELISA, WB, IHC, IF, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-BAX (IP:50599-2-Ig, 3ug; Detection:50599-2-Ig 1:2000) with Raji cells lysate 3500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 50599-2-Ig(BAX antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 50599-2-Ig(BAX antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
