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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [70]
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- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Other assay [2]
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- Product number
- MA5-13994 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Bax Monoclonal Antibody (2D2)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- MA5-13994 targets Bax in IF, IHC (P), and WB applications and shows reactivity with Human samples.
- Antibody clone number
- 2D2
- Concentration
- 0.2 mg/mL
Submitted references Age-related changes in testicular morphometry and function in Egyptian donkeys.
Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.
miR‑205‑3p promotes lung cancer progression by targeting APBB2.
Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.
Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis.
The protective effects of carnosine in alcohol-induced hepatic injury in rats.
Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death.
Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis.
Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program.
Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors.
Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors.
Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.
The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy.
NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria.
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy.
Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo.
Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma.
Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens.
4'-Chloro-3,5-dihydroxystilbene, a resveratrol derivative, induces lung cancer cell death.
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.
Effect of fetal sex on apoptosis-regulating proteins in trophoblasts of full-term human placenta.
Expression of the antiapoptosis gene Survivin predicts poor prognosis of stage III gastric adenocarcinoma.
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.
Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.
Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma.
A phase I pharmacokinetic and pharmacodynamic correlative study of the antisense Bcl-2 oligonucleotide g3139, in combination with carboplatin and paclitaxel, in patients with advanced solid tumors.
Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profiling.
Microwave antigen retrieval blocks endogenous peroxidase activity in immunohistochemistry.
Prognostic significance of cell proliferation and apoptosis-regulating proteins in Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma.
Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage.
Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity.
Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells.
A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins.
Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma.
Tea-induced apoptosis in human leukemia K562 cells as assessed by comet formation.
Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells.
Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line.
Prognostic significance of Bax and Fas ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma.
Antibody selection in immunohistochemical detection of cyclin D1 in mantle cell lymphoma.
Simultaneous bilateral breast carcinomas: a category with frequent coexpression of HER-2 and ER-alpha, high Ki-67 and bcl-2, and low p53.
Simultaneous bilateral breast carcinomas: a category with frequent coexpression of HER-2 and ER-alpha, high Ki-67 and bcl-2, and low p53.
Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin.
Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte?
p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy.
Expression of Bcl-2 family members and presence of Epstein-Barr virus in the regulation of cell growth and death in classical Hodgkin's lymphoma.
Expression of Bcl-2 family members and presence of Epstein-Barr virus in the regulation of cell growth and death in classical Hodgkin's lymphoma.
Prognostic value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and Bax immunohistochemical study.
Prognostic value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and Bax immunohistochemical study.
Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy.
Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy.
Pilomatrix carcinoma with lymph node metastases.
Pilomatrix carcinoma with lymph node metastases.
BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation.
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin.
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin.
The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer.
Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival.
Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival.
Reduced expression of both Bax and Bcl-2 is independently associated with lymph node metastasis in human breast carcinomas.
Reduced expression of both Bax and Bcl-2 is independently associated with lymph node metastasis in human breast carcinomas.
Human Meissner corpuscles express Bcl-2 but not Bax protein.
Human Meissner corpuscles express Bcl-2 but not Bax protein.
Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53.
Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53.
Escherichia coli induces apoptosis and proliferation of mammary cells.
Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.
Masoud SR, Kishta AA, Canisso IF, Abdel-Megeid NS, Fathalla SI, Shawky SM, Abdoon ASS
Reproduction in domestic animals = Zuchthygiene 2022 Nov;57(11):1319-1326
Reproduction in domestic animals = Zuchthygiene 2022 Nov;57(11):1319-1326
Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.
Zhang Q, Long J, Li N, Ma X, Zheng L
Frontiers in pharmacology 2021;12:594793
Frontiers in pharmacology 2021;12:594793
miR‑205‑3p promotes lung cancer progression by targeting APBB2.
Xu LB, Xiong J, Zhang YH, Dai Y, Ren XP, Ren YJ, Han D, Wei SH, Qi M
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.
Li Y, Ma H, Lu Y, Tan BJ, Xu L, Lawal TO, Mahady GB, Liu D
BioMed research international 2016;2016:2574637
BioMed research international 2016;2016:2574637
Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis.
Raemy E, Montessuit S, Pierredon S, van Kampen AH, Vaz FM, Martinou JC
Cell death and differentiation 2016 Jul;23(7):1165-74
Cell death and differentiation 2016 Jul;23(7):1165-74
The protective effects of carnosine in alcohol-induced hepatic injury in rats.
Baykara B, Micili SC, Tugyan K, Tekmen I, Bagriyanik H, Sonmez U, Sonmez A, Oktay G, Yener N, Ozbal S
Toxicology and industrial health 2014 Feb;30(1):25-32
Toxicology and industrial health 2014 Feb;30(1):25-32
Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death.
Essabbani A, Garcia L, Zonetti MJ, Fisco T, Pucci S, Chiocchia G
PloS one 2013;8(2):e54920
PloS one 2013;8(2):e54920
Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis.
Slipicevic A, Øy GF, Rosnes AK, Stakkestad Ø, Emilsen E, Engesæter B, Mælandsmo GM, Flørenes VA
Cancer biology & therapy 2013 Feb;14(2):146-54
Cancer biology & therapy 2013 Feb;14(2):146-54
Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program.
Mitra AP, Castelao JE, Hawes D, Tsao-Wei DD, Jiang X, Shi SR, Datar RH, Skinner EC, Stein JP, Groshen S, Yu MC, Ross RK, Skinner DG, Cortessis VK, Cote RJ
Cancer 2013 Feb 15;119(4):756-65
Cancer 2013 Feb 15;119(4):756-65
Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors.
Ozer H, Yenicesu G, Arici S, Cetin M, Tuncer E, Cetin A
Diagnostic pathology 2012 Sep 20;7:124
Diagnostic pathology 2012 Sep 20;7:124
Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors.
Gao C, Guo WJ, Wang AY
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2012 Mar;120(3):171-81
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2012 Mar;120(3):171-81
Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.
Árvai K, Nagy K, Barti-Juhász H, Peták I, Krenács T, Micsik T, Végső G, Perner F, Szende B
Pathology oncology research : POR 2012 Jul;18(3):607-14
Pathology oncology research : POR 2012 Jul;18(3):607-14
The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy.
Lazarevic B, Hammarström C, Yang J, Ramberg H, Diep LM, Karlsen SJ, Kucuk O, Saatcioglu F, Taskèn KA, Svindland A
The British journal of nutrition 2012 Dec 28;108(12):2138-47
The British journal of nutrition 2012 Dec 28;108(12):2138-47
NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria.
Molouki A, Yusoff K
Virology journal 2012 Aug 30;9:179
Virology journal 2012 Aug 30;9:179
Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy.
Aydin F, Levent Y, Nilgun S, Pancar YE, Yasar TA
Indian journal of dermatology 2011 Sep-Oct;56(5):501-4
Indian journal of dermatology 2011 Sep-Oct;56(5):501-4
Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo.
Tian LL, Yue W, Zhu F, Li S, Li W
Journal of cellular physiology 2011 Jul;226(7):1860-7
Journal of cellular physiology 2011 Jul;226(7):1860-7
Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma.
Yu F, Hao X, Zhao H, Ge C, Yao M, Yang S, Li J
Liver international : official journal of the International Association for the Study of the Liver 2010 May;30(5):703-14
Liver international : official journal of the International Association for the Study of the Liver 2010 May;30(5):703-14
Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens.
Karamitopoulou E, Rentsch CA, Markwalder R, Vallan C, Thalmann GN, Brunner T
Pathology 2010 Jan;42(1):37-42
Pathology 2010 Jan;42(1):37-42
4'-Chloro-3,5-dihydroxystilbene, a resveratrol derivative, induces lung cancer cell death.
Wu JY, Tsai KW, Shee JJ, Li YZ, Chen CH, Chuang JJ, Liu YW
Acta pharmacologica Sinica 2010 Jan;31(1):81-92
Acta pharmacologica Sinica 2010 Jan;31(1):81-92
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.
Li CH, Cheng YW, Liao PL, Kang JJ
Neoplasia (New York, N.Y.) 2010 Feb;12(2):150-60
Neoplasia (New York, N.Y.) 2010 Feb;12(2):150-60
Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.
Li CH, Cheng YW, Liao PL, Kang JJ
Neoplasia (New York, N.Y.) 2010 Feb;12(2):150-60
Neoplasia (New York, N.Y.) 2010 Feb;12(2):150-60
Effect of fetal sex on apoptosis-regulating proteins in trophoblasts of full-term human placenta.
Gol M, Tuna B
Gynecologic and obstetric investigation 2009;67(1):53-6
Gynecologic and obstetric investigation 2009;67(1):53-6
Expression of the antiapoptosis gene Survivin predicts poor prognosis of stage III gastric adenocarcinoma.
Song KY, Jung CK, Park WS, Park CH
Japanese journal of clinical oncology 2009 May;39(5):290-6
Japanese journal of clinical oncology 2009 May;39(5):290-6
Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, Lai CH, Chen BH, Lee Chao PD, Wan L, Tsai FJ
Biochemical and biophysical research communications 2009 Jan 23;378(4):683-8
Biochemical and biophysical research communications 2009 Jan 23;378(4):683-8
Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.
Pucci S, Mazzarelli P, Sesti F, Boothman DA, Spagnoli LG
Cell cycle (Georgetown, Tex.) 2009 Feb 1;8(3):473-81
Cell cycle (Georgetown, Tex.) 2009 Feb 1;8(3):473-81
Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.
Pucci S, Mazzarelli P, Sesti F, Boothman DA, Spagnoli LG
Cell cycle (Georgetown, Tex.) 2009 Feb 1;8(3):473-81
Cell cycle (Georgetown, Tex.) 2009 Feb 1;8(3):473-81
Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma.
Gao C, Wang AY
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Dec;57(12):1139-48
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Dec;57(12):1139-48
A phase I pharmacokinetic and pharmacodynamic correlative study of the antisense Bcl-2 oligonucleotide g3139, in combination with carboplatin and paclitaxel, in patients with advanced solid tumors.
Liu G, Kolesar J, McNeel DG, Leith C, Schell K, Eickhoff J, Lee F, Traynor A, Marnocha R, Alberti D, Zwiebel J, Wilding G
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 May 1;14(9):2732-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 May 1;14(9):2732-9
Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profiling.
Murphy KM, Chen F, Clark DP
Human pathology 2008 Mar;39(3):420-6
Human pathology 2008 Mar;39(3):420-6
Microwave antigen retrieval blocks endogenous peroxidase activity in immunohistochemistry.
Gao C, Wang AY, Han YJ
Applied immunohistochemistry & molecular morphology : AIMM 2008 Jul;16(4):393-9
Applied immunohistochemistry & molecular morphology : AIMM 2008 Jul;16(4):393-9
Prognostic significance of cell proliferation and apoptosis-regulating proteins in Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma.
Aktaş S, Kargi A, Olgun N, Diniz G, Erbay A, Vergin C
Lymphatic research and biology 2007;5(3):175-82
Lymphatic research and biology 2007;5(3):175-82
Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage.
Ricci F, Pucci S, Sesti F, Missiroli F, Cerulli L, Spagnoli LG
Ophthalmic research 2007;39(3):164-73
Ophthalmic research 2007;39(3):164-73
Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity.
Mukherjee Nee Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Dey S, Roy M
Molecular and cellular biochemistry 2007 Mar;297(1-2):31-9
Molecular and cellular biochemistry 2007 Mar;297(1-2):31-9
Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells.
Yang YC, Hsu YT, Wu CC, Chen HT, Chang MS
Biochemical and biophysical research communications 2006 May 5;343(2):428-34
Biochemical and biophysical research communications 2006 May 5;343(2):428-34
A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins.
Nishikawa T, Nakajima T, Moriguchi M, Jo M, Sekoguchi S, Ishii M, Takashima H, Katagishi T, Kimura H, Minami M, Itoh Y, Kagawa K, Okanoue T
Journal of hepatology 2006 Jun;44(6):1074-82
Journal of hepatology 2006 Jun;44(6):1074-82
Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma.
Sun B, Sun Y, Wang J, Zhao X, Wang X, Hao X
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2006 Jun;15(3):258-65
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2006 Jun;15(3):258-65
Tea-induced apoptosis in human leukemia K562 cells as assessed by comet formation.
Chakraborty S, Kundu T, Dey S, Bhattacharya RK, Siddiqi M, Roy M
Asian Pacific journal of cancer prevention : APJCP 2006 Apr-Jun;7(2):201-7
Asian Pacific journal of cancer prevention : APJCP 2006 Apr-Jun;7(2):201-7
Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells.
Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Roy M
Mutation research 2006 Apr 11;596(1-2):81-90
Mutation research 2006 Apr 11;596(1-2):81-90
Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line.
Skvortsov S, Skvortsova I, Sarg B, Loeffler-Ragg J, Lindner H, Lukas P, Tabernero J, Zwierzina H
Apoptosis : an international journal on programmed cell death 2005 Oct;10(5):1175-86
Apoptosis : an international journal on programmed cell death 2005 Oct;10(5):1175-86
Prognostic significance of Bax and Fas ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma.
Kokturk N, Firat P, Akay H, Kadilar C, Ozturk C, Zorlu F, Gungen Y, Emri S
Lung cancer (Amsterdam, Netherlands) 2005 Nov;50(2):189-98
Lung cancer (Amsterdam, Netherlands) 2005 Nov;50(2):189-98
Antibody selection in immunohistochemical detection of cyclin D1 in mantle cell lymphoma.
Torlakovic E, Nielsen S, Vyberg M
American journal of clinical pathology 2005 Nov;124(5):782-9
American journal of clinical pathology 2005 Nov;124(5):782-9
Simultaneous bilateral breast carcinomas: a category with frequent coexpression of HER-2 and ER-alpha, high Ki-67 and bcl-2, and low p53.
Bassarova AV, Nesland JM, Sedloev T, Lilleby W, Hristova SL, Trifonov DY, Torlakovic E
International journal of surgical pathology 2005 Jul;13(3):239-46
International journal of surgical pathology 2005 Jul;13(3):239-46
Simultaneous bilateral breast carcinomas: a category with frequent coexpression of HER-2 and ER-alpha, high Ki-67 and bcl-2, and low p53.
Bassarova AV, Nesland JM, Sedloev T, Lilleby W, Hristova SL, Trifonov DY, Torlakovic E
International journal of surgical pathology 2005 Jul;13(3):239-46
International journal of surgical pathology 2005 Jul;13(3):239-46
Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin.
Kundu T, Dey S, Roy M, Siddiqi M, Bhattacharya RK
Cancer letters 2005 Dec 8;230(1):111-21
Cancer letters 2005 Dec 8;230(1):111-21
Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte?
Narula N, Narula J, Zhang PJ, Haider N, Raghunath PN, Brittin R, Gorman JH 3rd, Gorman RC, Tomaszewski JE
The Annals of thoracic surgery 2005 Apr;79(4):1333-7; discussion 1337
The Annals of thoracic surgery 2005 Apr;79(4):1333-7; discussion 1337
p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy.
Liu SS, Leung RC, Chan KY, Chiu PM, Cheung AN, Tam KF, Ng TY, Wong LC, Ngan HY
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 May 15;10(10):3309-16
Clinical cancer research : an official journal of the American Association for Cancer Research 2004 May 15;10(10):3309-16
Expression of Bcl-2 family members and presence of Epstein-Barr virus in the regulation of cell growth and death in classical Hodgkin's lymphoma.
Kim LH, Nadarajah VS, Peh SC, Poppema S
Histopathology 2004 Mar;44(3):257-67
Histopathology 2004 Mar;44(3):257-67
Expression of Bcl-2 family members and presence of Epstein-Barr virus in the regulation of cell growth and death in classical Hodgkin's lymphoma.
Kim LH, Nadarajah VS, Peh SC, Poppema S
Histopathology 2004 Mar;44(3):257-67
Histopathology 2004 Mar;44(3):257-67
Prognostic value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and Bax immunohistochemical study.
Sirvent JJ, Aguilar MC, Olona M, Pelegrí A, Blázquez S, Gutiérrez C
Histology and histopathology 2004 Jul;19(3):759-70
Histology and histopathology 2004 Jul;19(3):759-70
Prognostic value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and Bax immunohistochemical study.
Sirvent JJ, Aguilar MC, Olona M, Pelegrí A, Blázquez S, Gutiérrez C
Histology and histopathology 2004 Jul;19(3):759-70
Histology and histopathology 2004 Jul;19(3):759-70
Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy.
Qiu LQ, Sinniah R, I-Hong Hsu S
Journal of the American Society of Nephrology : JASN 2004 Jan;15(1):79-90
Journal of the American Society of Nephrology : JASN 2004 Jan;15(1):79-90
Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy.
Qiu LQ, Sinniah R, I-Hong Hsu S
Journal of the American Society of Nephrology : JASN 2004 Jan;15(1):79-90
Journal of the American Society of Nephrology : JASN 2004 Jan;15(1):79-90
Pilomatrix carcinoma with lymph node metastases.
Bassarova A, Nesland JM, Sedloev T, Danielsen H, Christova S
Journal of cutaneous pathology 2004 Apr;31(4):330-5
Journal of cutaneous pathology 2004 Apr;31(4):330-5
Pilomatrix carcinoma with lymph node metastases.
Bassarova A, Nesland JM, Sedloev T, Danielsen H, Christova S
Journal of cutaneous pathology 2004 Apr;31(4):330-5
Journal of cutaneous pathology 2004 Apr;31(4):330-5
BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation.
Rassidakis GZ, Jones D, Lai R, Ramalingam P, Sarris AH, McDonnell TJ, Medeiros LJ
The Journal of pathology 2003 Jun;200(2):240-8
The Journal of pathology 2003 Jun;200(2):240-8
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
Gourdier I, Del Rio M, Crabbé L, Candeil L, Copois V, Ychou M, Auffray C, Martineau P, Mechti N, Pommier Y, Pau B
FEBS letters 2002 Oct 9;529(2-3):232-6
FEBS letters 2002 Oct 9;529(2-3):232-6
Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.
Gourdier I, Del Rio M, Crabbé L, Candeil L, Copois V, Ychou M, Auffray C, Martineau P, Mechti N, Pommier Y, Pau B
FEBS letters 2002 Oct 9;529(2-3):232-6
FEBS letters 2002 Oct 9;529(2-3):232-6
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin.
Lopes JM, Nesland JM, Reis-Filho JS, Holm R
Histopathology 2002 May;40(5):464-71
Histopathology 2002 May;40(5):464-71
Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin.
Lopes JM, Nesland JM, Reis-Filho JS, Holm R
Histopathology 2002 May;40(5):464-71
Histopathology 2002 May;40(5):464-71
The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer.
Sjöström J, Blomqvist C, von Boguslawski K, Bengtsson NO, Mjaaland I, Malmström P, Ostenstadt B, Wist E, Valvere V, Takayama S, Reed JC, Saksela E
Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Mar;8(3):811-6
Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Mar;8(3):811-6
Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival.
Korkolopoulou P, Lazaris ACh, Konstantinidou AE, Kavantzas N, Patsouris E, Christodoulou P, Thomas-Tsagli E, Davaris P
European urology 2002 Mar;41(3):274-83
European urology 2002 Mar;41(3):274-83
Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival.
Korkolopoulou P, Lazaris ACh, Konstantinidou AE, Kavantzas N, Patsouris E, Christodoulou P, Thomas-Tsagli E, Davaris P
European urology 2002 Mar;41(3):274-83
European urology 2002 Mar;41(3):274-83
Reduced expression of both Bax and Bcl-2 is independently associated with lymph node metastasis in human breast carcinomas.
Bukholm IR, Bukholm G, Nesland JM
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002 Mar;110(3):214-20
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002 Mar;110(3):214-20
Reduced expression of both Bax and Bcl-2 is independently associated with lymph node metastasis in human breast carcinomas.
Bukholm IR, Bukholm G, Nesland JM
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002 Mar;110(3):214-20
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002 Mar;110(3):214-20
Human Meissner corpuscles express Bcl-2 but not Bax protein.
Ortiz-Rey JA, Alvarez-Alvarez C, Antón-Badiola I, San Miguel-Fraile P, De la Fuente-Buceta A
Neuroscience letters 2002 Aug 30;329(2):240-2
Neuroscience letters 2002 Aug 30;329(2):240-2
Human Meissner corpuscles express Bcl-2 but not Bax protein.
Ortiz-Rey JA, Alvarez-Alvarez C, Antón-Badiola I, San Miguel-Fraile P, De la Fuente-Buceta A
Neuroscience letters 2002 Aug 30;329(2):240-2
Neuroscience letters 2002 Aug 30;329(2):240-2
Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53.
Ong F, Moonen LM, Gallee MP, ten Bosch C, Zerp SF, Hart AA, Bartelink H, Verheij M
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2001 Nov;61(2):169-75
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2001 Nov;61(2):169-75
Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53.
Ong F, Moonen LM, Gallee MP, ten Bosch C, Zerp SF, Hart AA, Bartelink H, Verheij M
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2001 Nov;61(2):169-75
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2001 Nov;61(2):169-75
Escherichia coli induces apoptosis and proliferation of mammary cells.
Long E, Capuco AV, Wood DL, Sonstegard T, Tomita G, Paape MJ, Zhao X
Cell death and differentiation 2001 Aug;8(8):808-16
Cell death and differentiation 2001 Aug;8(8):808-16
Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.
Goetzl EJ, Kong Y, Mei B
Journal of immunology (Baltimore, Md. : 1950) 1999 Feb 15;162(4):2049-56
Journal of immunology (Baltimore, Md. : 1950) 1999 Feb 15;162(4):2049-56
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Western blot of Bax using Bax Monoclonal Antibody (Product # MA5-13994) on HeLa Cells.
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- Knockout of BAX was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, AssayID CRISPR612938_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Western blot analysis of BAX was performed by loading 30 µg of HeLa wild type (Lane 1), HeLa CAS9 (Lane 2) and HeLa BAX KO (Lane 3) whole cell extracts. The samples were electrophoresed using Novex® NuPAGE® 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with Anti-Bax Monoclonal Antibody (2D2) (Product # MA5-13994) at a dilution of 1 µg/mL and Goat anti-Mouse IgG (H+L), Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4,000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005). Loss of signal upon CRISPR mediated knockout (KO) using the LentiArray™ CRISPR product line confirms that antibody is specific to BAX.
Supportive validation
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- Formalin-fixed, paraffin-embedded human Hodgkins lymphoma stained with Bax antibody using peroxidase-conjugate and DAB chromogen. Note membrane staining of Reedternberg cells.
Supportive validation
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- Invitrogen Antibodies (provider)
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- NULL
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 6. miR-205-3p antagomir inhibits lung cancer growth and promotes apoptosis in mouse xenografts. (A) Representative images of excised xenograft tumors and (B) tumor volumes from mice treated with the antagomir NC or miR-205-3p antagomir. (C) Reverse transcription-quantitative PCR analysis was used to detect miR-205-3p expression in tumors. (D) Western blot analysis was used to detect APBB2, Bax and Bcl-2 protein expression levels in tumors. *P
