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- Antigen structure
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- Product number
- 60267-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- BAX antibody
- Antibody type
- Monoclonal
- Description
- BAX antibody (Cat. #60267-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4G5E8
- Vial size
- 20ul, 150ul
Submitted references A novel Nilotinib derivative N-12 inhibits the proliferation and migration of colon cancer cells through the EMT signaling pathway.
Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma Cells.
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells.
Reactive oxygen species/hypoxia dual-responsive polymers combined with melatonin inhibited PANoptosis of retinal ganglion cells for acute glaucoma treatment.
Monitoring early micro-oxidation under refrigeration: iron and oxidative markers predict quality loss in grass carp.
Seminal plasma extracellular vesicle-derived miR-296-3p targets PLA2G6 to enhance boar sperm motility by lowering Lys Phosphatidylcholine.
8-Oxoguanine modifications in seed regions of miRNAs regulating P16 promote aging by reshaping gene regulatory networks.
Saikosaponin D alleviates chronic prostatitis/chronic pelvic pain syndrome by regulating the NF-κB pathway via lncRNA5682.
FXR-mediated transcriptional regulation of KLF11 mitigates contrast-induced acute kidney injury via suppressing JAK2/STAT3 pathway.
The role of nGPx4 in resisting DEHP-induced DNA damage and reducing caspase-independent cell death in male germ cells.
A Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
Biomineralized Bacterial Biohybrid for Coordinated and Self-Sustained In Situ Synthesis of Antitumor Photothermal Agent and Photosensitizer.
Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.
Targeting CCNB1 Repressed Cartilage Degradation Induced by Inflammation Through NF-κB Pathway in Osteoarthritis.
Zearalenone Induces Oxidative Stress and Apoptosis in the Jejunum of Weaned Piglets via the p53/Nrf2 Signaling Pathway.
The CDO1-ACSM3 Axis Mediates Renal Tubule Lipid Deposition and Injury by Causing Mitochondrial Dysfunction in Lupus Nephritis.
CSF1 regulates inflammation and apoptosis in intervertebral disc degeneration.
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Thioredoxin protects against diabetic hearing loss by regulating TOMM22 mediated mitochondrial autophagy in hair cells and inhibiting microglial M1 polarization.
Nobiletin enhances Doxorubicin sensitivity in osteosarcoma through ER stress-induced apoptosis mediated by the PI3K/AKT pathway.
Ferulic Acid Alleviates Chemotherapy-Induced POI by Targeting the Grp78 and Perk-eIF2α-ATF4-CHOP Pathway to Attenuate Endoplasmic Reticulum Stress.
Modulating GRP75 to restore calcium homeostasis: a novel neuroprotective strategy of CRSE6(#) in Parkinson's disease models.
A Dual-Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor-Associated Osteolysis Restoration via Sequential Release.
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
Capicua mediates interleukin-2 withdrawal-induced death of activated CD8(+) T cells.
Salvia miltiorrhiza extract attenuates cardiorenal syndrome by inhibiting IL-1β mediated cross-talk between heart and kidney.
Design and synthesis of dual mitochondria-targeted biguanide derivatives as potential anticancer agents.
The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.
CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis.
Poria cocos polysaccharide inhibits Porcine Deltacoronavirus replication in vitro through regulating apoptosis by PI3K-Akt/NF-κB signaling pathway.
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein.
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
PIEZO1 Mediates Apoptosis of Endothelial Cells via Enhancing HMGA2 Expression Under Simulated Microgravity.
α-terpineol induces apoptosis in melanoma cells and its underlying mechanism.
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Unsymmetrical dimethylhydrazine induces dose-dependent liver toxicity in rats via oxidative stress and PI3K/Akt pathway-mediated apoptosis.
MTP18 as a prognostic biomarker and therapeutic target in lung adenocarcinoma.
TRV130 inhibits colon cancer progression via suppressing the Hedgehog signaling pathway: in vitro and in vivo evidence.
Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy.
Nucleophosmin Promotes Regulated Cell Death in Podocyte Injury.
Transcriptomics-guided high-throughput drug screening identifies potent therapies for P53 pathway altered DIPG/DMG.
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Intranasal triptolide in mice: a strategy to reduce neuroinflammation and boost cognitive function.
γ-Glutamylcysteine Alleviates t-BHP-Induced Oxidative Damage in NIH/3T3 Fibroblasts by Promoting Nuclear Translocation of Nrf2.
Lycium barbarum polysaccharides enhance testicular spermatogenesis in d-galactose-induced aging rats via calcium signaling.
Acute sleep deprivation reduces thermotolerance and exacerbates heat stroke via disruption of intestinal barrier integrity in rats.
Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia-Reperfusion Injury.
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
ZIKV envelope protein is a strong blocker of early directional differentiation in the neural lineage.
Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.
Photobiomodulation therapy inhibits ISO-induced myocardial remodeling in mice through modulating TGF-β/Smad7 and PI3K/AKT pathways.
Retigabine ameliorates CRS-induced depressive-like behaviors and cognitive impairment by inhibiting endoplasmic reticulum stress-mediated apoptosis.
Remimazolam Ameliorates Autistic-Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD.
Lysosome-targeted degradation of leucine-rich alpha-2 glycoprotein 1 enables chemosensitization to 5-fluorouracil in colorectal cancer.
Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model.
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis.
Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.
Identification and Functional Characterization of a Novel PRPS1 Variant in X-Linked Nonsyndromic Hearing Loss: Insights From Zebrafish and Cellular Models.
The protective influence of Astragalus on rat models of preeclampsia.
Multi-Focused Acoustic Radiation Force Impulse Modulation of Murine Hepatic Xenografts Enhances Nanoscale DOX@Lip Delivery and Therapeutic Effect.
Leonurine Attenuates CCl(4)-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.
Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway.
Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway.
The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity.
RBM39 Functions as a Potential Oncogene Through the NF-κB Signaling Pathway in Colorectal Cancer Cells.
Eupalinolide A inhibits cancer progression and induces ferroptosis and apoptosis by targeting the AMPK/mTOR/SCD1 signalling in non-small cell lung cancer.
Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments.
Chinese massage therapy (Tuina) inhibits motor neuron apoptosis in rats with sciatic nerve injury by regulating the cPLA2 and RhoA/ROCK2 signaling pathways.
Protective effects of Atractylodes macrocephala polysaccharides on acetaminophen-induced liver injury.
Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing.
Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.
Discovery of active compounds in Danshen-Chuanxiong formula for blood-brain barrier protection: a multi-parametric study using an OGD/R-induced spheroid model.
A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death.
New cardiac glycosides from Adonis amurensis with potent antitumor activity.
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
Role of RET-Regulated GDNF-GFRα1 Endocytosis in Methamphetamine-Induced Neurotoxicity.
BAP31 represses endoplasmic reticulum stress-mediated apoptosis and alleviates neurodegeneration in Parkinson's disease.
Investigating C(7) modified tetrandrine derivatives for synthesis anti-hepatocellular carcinoma activity and mechanistic insights.
HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer models.
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
The BPIFA2 - LRP5 axis orchestrates mitochondrial dysfunction to mediate kidney injury in lupus nephritis.
High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy.
Nitrate Promotes the Survival of Diabetic Skin Flaps by Enhancing Autophagy Through the AMPK Signaling Pathway.
10% carbon dioxide improves cognitive function after subarachnoid hemorrhage in rats: inhibiting neuronal apoptosis through the PI3K/AKT signaling pathway.
Inorganic nitrate attenuates neuroinflammation after traumatic brain injury via Sialin.
Cadmium-induced apoptosis of granulosa cells is mediated by excessive activation of mitophagy and ROS-mediated mitochondrial dysfunction.
Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.
Targeting c-Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple-negative breast cancer.
The protective role of quercetin in cataract lenses and its mechanisms related to the hippo signaling pathway.
The Interventional Effects and Mechanisms of Lonidamine in Combination with Apigenin on Colorectal Cancer.
Luopan Mountain Pig Bone Marrow Mesenchymal Stem Cells Promote Liver Regeneration in D-Galactosamine-Induced Acute Liver Failure Rats by Regulating the PTEN-PI3K/Akt/mTOR Pathway.
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Empagliflozin-pretreated BMSC exosomes attenuate myocardial ischemia-reperfusion injury by enhancing atad3a/pink1-dependent mitophagy.
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells.
Ganfule capsule alleviates AFB1-induced toxic liver injury via inhibiting oxidative stress, inflammatory response, and apoptosis.
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway.
RIPK4-p53 interaction drives aflatoxin B1-induced renal mitochondrial apoptosis via Ser15 phosphorylation: A CRISPR-Cas9 mechanistic study.
Mechanistic insights into the Ganfule capsule in alleviating alcoholic liver disease.
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties.
Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications.
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Mechanism of action of HuPoSan on EMs rats as revealed by multi-omics combined with network pharmacology.
Xiaoyao San and Guipi Tang, alone or combined, relieve postpartum depression via AGE‑RAGE‑mediated autophagy and apoptosis.
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Knockdown of SUCLG2 inhibits glioblastoma proliferation and promotes apoptosis through LMNA acetylation and the mediation of H4K16la lactylation.
Endoplasmic reticulum-mitochondria dual-targeting nanoplatform suppresses cancer stemness and enhances colorectal cancer immunotherapy.
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
The effect of autophagy activation on apoptosis and myofibrillar structural proteins during the post-mortem storage of Esox lucius.
2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis.
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Hyaluronic acid/ε-polylysine hydrogel enriched with Saussurea involucrata polysaccharide for improved skin dryness induced by ultraviolet radiation.
Matrix metallopeptidase 2-responsive curcumin-loaded nanoparticles-induced signal transducer and activator of transcription 3 inhibition suppresses glioblastoma multiforme growth via enhancing nuclear factor erythroid 2-related factor 2 activity.
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.
S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Compound probiotics alleviate hyperuricemia-induced renal injury via restoring gut microbiota and metabolism.
Liquiritigenin protects against cadmium-induced testis damage in mice by inhibiting apoptosis and activating androgen receptor.
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Microneedle-mediated hypoxic extracellular vesicle-encapsulated selenium nanoparticles delivery to treat androgenetic alopecia.
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
Knockdown of HOTAIR Alleviates High Glucose-Induced Apoptosis and Inflammation in Retinal Pigment Epithelial Cells.
SGK1 mediates herpes simplex keratitis via the PI3K/SGK1/ Wnt signaling pathways.
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles used for androgenic alopecia.
Exploring the effect of chlorogenic acid on oxidative stress and autophagy in dry eye mice via the AMPK/ULK1 pathway.
CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome.
Blocking GATA6 Alleviates Pyroptosis and Inhibits Abdominal Wall Endometriosis Lesion Growth Through Inactivating the PI3K/AKT Pathway.
Application of (68)Ga- and (177)Lu-Labeled FAP Inhibitor in Evaluation and Treatment of Cardiac Fibrosis After Myocardial Infarction.
Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Through the Promotion of Type 2 Macrophage Polarization.
miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition.
Paeonol enhances a recombinant EGFR-targeted fusion protein-drug conjugate induced antitumor efficacy in esophageal cancer.
Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis.
Can linc00968 Regulate SH-SY5Y Cell Apoptosis Induced by Amyloid beta Neurotoxicity?
Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy.
L1CAM mimetic compound duloxetine improves cognitive impairment in 5xFAD mice and protects Aβ1-42-damaged HT22 cells.
Long Noncoding RNA NONHSAT233728.1 Promotes ROS Accumulation and Granulosa Cell Apoptosis by Regulating the MAPK/ERK1/2 Signaling Pathway.
Podophyllum hexandrum Royle mitigates perimenopausal symptoms in an OVX rat model by activating the PI3K/AKT/mTOR pathway and enhancing estrogen receptor expression.
Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking.
TREM2 Modulates Postoperative Cognitive Function in Aged Mice by Inhibiting the NLRP3/caspase-1 Pathway and Apoptosis via PLCγ2 Activation.
The novel piperine derivative MHJ-LN inhibits breast cancer by inducing apoptosis via p53 activation.
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD-MCI mice.
2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.
Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis.
Soy Isoflavone Supplementation in Sow Diet Enhances Antioxidant Status and Promotes Intestinal Health of Newborn Piglets.
Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest.
Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway.
Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells.
METTL3 methylated KIF15 promotes nasopharyngeal carcinoma progression and radiation resistance by blocking ATG7-mediated autophagy through the activation of STAT3 pathway.
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity.
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway.
Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer.
A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer.
Discovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy.
Citrinin-Induced Cellular Damage: Insights from SH-SY5Y Cell Line Studies.
Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss.
Self-Assembled Pt/Honokiol Nanomicelles for the Treatment of Sepsis-Associated Acute Kidney Injury.
ACSL5 promotes lipid deposition and lipoapoptosis in proximal tubular epithelial cells of diabetic kidney disease.
MiR-146a-5p downregulated TRAF6/NF-κB p65 pathway to attenuate the injury of HT-22 cells induced by oxygen-glucose deprivation/reoxygenation.
Methamphetamine inhibits huntingtin-associated protein 1-mediated tyrosine receptor kinase B endocytosis resulting the neuroprotective dysfunction of brain-derived neurotrophic factor.
Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction.
Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis.
Role of calcium overload-mediated disruption of mitochondrial dynamics in offspring neurotoxicity due to methylmercury exposure during pregnancy and lactation.
A quercetin nanoparticle combined with a 3D-printed decellularized extracellular matrix/ gelatin methacryloyl/sodium alginate biomimetic tumor model for the treatment of melanoma.
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
METRNL exerts cytoprotective effects on EPCs via regulation of the E2F1-TXNIP axis in obese limb ischemia.
Lactobacillus gasseri prevents ibrutinib-associated atrial fibrillation through butyrate.
The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy.
Iron overload mediates cytarabine resistance in AML by inhibiting the TP53 signaling pathway.
Dan-Shen-Yin against alcohol-induced gastric injury in rats by inhibiting apoptosis via IP3R-controlled calcium release.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
The effects of metformin on inflammation and apoptosis in rats with preeclampsia.
CircRNA circACTN4 Promotes the Progression of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the miR-424-5p/NCAPG/Wnt Axis.
Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells.
Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis: Modulating Crotonylation in Ulcerative Colitis.
SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1.
DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.
A Novel COL12A1 Mutation Causes Oral Tissue Abnormalities by Regulating Gingival Fibroblast Function.
COX-2 targeting Ru-arene complexes from metal-ligand synergistic enhancement strategy for breast cancer therapy.
Arsenic-induced circFNDC3B regulates apoptosis through dysregulation of NF-κB Signaling.
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
A machine learning-based glycolysis and fatty acid metabolism-related prognostic signature is constructed and identified ACSL5 as a novel marker inhibiting the proliferation of breast cancer.
Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer.
An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.
Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer.
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
Identification and biological evaluation of novel indole-2-one derivatives as BRD4-BD2 inhibitors.
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis.
Icariin attenuates oxidative stress via SIRT1/PGC-1α pathway in SAH mice.
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
Crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress in apoptosis: Implications for grass carp flesh quality during cold storage.
Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer's disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches.
Pyrazolamide derivative T1 inhibits hepatocellular carcinoma cell proliferation through MAPK pathway modulation.
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
Mechanisms of Differential Sensitivity to Ethanol-Induced Apoptosis in Mouse Spinal Cord at Different Developmental Stages-Akt/GSK Signaling and BAX.
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Inhibition of MALAT1 facilitates ROS accumulation via the Keap1/HO-1 pathway to enhance photodynamic therapy in secondary hyperparathyroidism.
Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload.
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
Exploring the Molecular Mechanism of 1,25(OH)(2)D(3) Reversal of Sorafenib Resistance in Hepatocellular Carcinoma Based on Network Pharmacology and Experimental Validation.
The African swine fever virus MGF360-16R protein functions as a mitochondrial-dependent apoptosis inducer by competing with BAX to bind to the HSP60 protein.
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury.
Molecular Mechanism of Caulis Spatholobi in the Treatment of Chronic Myeloid Leukemia based on Network Pharmacology and Experimental Verification.
Polydopamine-Based Nanoparticles for Synergistic Chemotherapy of Prostate Cancer.
Rebaudioside B Attenuates Lung Ischemia-reperfusion Injury Associated Apoptosis and Inflammation.
Cross-border regulation of the STK39/MAPK14 pathway by Lycium barbarum miR166a to inhibit triple-negative breast cancer.
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells.
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Qingre Huoxue decoction attenuates myocardial ischemia‒reperfusion injury by regulating the autophagy‒endoplasmic reticulum stress axis via FAM134B-mediated ER-phagy.
Baitouweng decoction alleviates ulcerative colitis by regulating tryptophan metabolism through DOPA decarboxylase promotion.
Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy.
B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosis.
Induction of apoptosis by oridonin in nonfunctioning pituitary adenoma cells.
Increased expression of SLC25A18 is associated with Alzheimer's disease and is involved in Aβ42-induced mitochondrial dysfunction and apoptosis in neuronal cells.
Esculentoside H reduces the PANoptosis and protects the blood-brain barrier after cerebral ischemia/reperfusion through the TLE1/PI3K/AKT signaling pathway.
Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor.
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.
Catecholamines-based myocardial injury after acute ischemic stroke and effects of Naoxintong capsule therapy.
Exercise-promoted adiponectin secretion activates autolysosomes to protect the liver of ApoE(-/-) mice from a high-fat diet.
Omaveloxolone ameliorates glucocorticoid-induced osteonecrosis of the femoral head by promoting osteogenesis and angiogenesis.
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.
Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice.
Design, synthesis, and biological evaluation of naphthalene imidazo[1,2-b]pyridazine hybrid derivatives as VEGFR selective inhibitors.
The resistance to anoikis, mediated by Spp1, and the evasion of immune surveillance facilitate the invasion and metastasis of hepatocellular carcinoma.
Emodin combined with 5-aminolevulinic acid photodynamic therapy inhibits condyloma acuminate angiogenesis by targeting SerRS.
Prebiotic stachyose inhibits PRDX5 activity and castration-resistant prostate cancer development.
Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
Identification and biological evaluation of fused tetrahydroisoquinoline derivatives as Wnt/β-catenin signaling inhibitors to suppress colorectal cancer.
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury.
CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy.
Peroxiredoxin-5 alleviates early brain injury after subarachnoid hemorrhage by reducing oxidative stress.
Protective Effects of Gastrodin Against Gentamicin-Induced Vestibular Damage by the Notch Signaling Pathway.
FAM83D promotes the progression of 4NQO-induced esophageal carcinoma via inhibiting FBWX7.
NOD2 reduces the chemoresistance of melanoma by inhibiting the TYMS/PLK1 signaling axis.
Alcohol promotes hepatocyte injury via ER stress sensor XBP1s mediated regulation of autophagy and lysosomal activity.
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm.
Mechanism of cold exposure delaying wound healing in mice.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure.
Pesticide metabolite 3, 5, 6-trichloro-2-pyridinol causes massive damage to the cochlea resulting in hearing loss in adult mice.
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
BL-918 alleviates oxidative stress in rats after subarachnoid hemorrhage by promoting mitophagy through the ULK1/PINK1/Parkin pathway.
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
DNAJA1‑knockout alleviates heat stroke‑induced endothelial barrier disruption via improving thermal tolerance and suppressing the MLCK‑MLC signaling pathway.
Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation.
Rapid discovery of a novel "green" and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy.
A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin-induced hepatotoxicity in mice.
Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21.
Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia.
High expression of B7-H3 on monocyte/macrophages in tumor microenvironment promotes lung cancer progression by inhibiting apoptosis.
Shuganning Injection Suppresses Apoptosis for Protecting Against Cantharidin-Induced Liver Injury by Network Pharmacology and Experiment Validation.
A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
Defective autophagy contributes to bupivacaine-induced aggravation of painful diabetic neuropathy in db/db mice.
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage.
Effect of black cloth ointment on hypertrophic scar formation: An investigation using integrated network pharmacology and animal assay.
Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT.
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd.
Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma.
CircZfp644-205 inhibits osteoblast differentiation and induces apoptosis of pre-osteoblasts via sponging miR-455-3p and promoting SMAD2 expression.
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy.
Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora.
2'-Hydroxycinnamaldehyde Alleviates Intestinal Inflammation by Attenuating Intestinal Mucosal Barrier Damage Via Directly Inhibiting STAT3.
Study on the mechanism of S100A4-mediated cancer oncogenesis in uveal melanoma cells through the integration of bioinformatics and in vitro experiments.
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity.
Evolocumab prevents atrial fibrillation in rheumatoid arthritis rats through restraint of PCSK9 induced atrial remodeling.
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2(+) axis.
FUDNC1-dependent mitophagy ameliorate motor neuron death in an amyotrophic lateral sclerosis mouse model.
THSG alleviates cerebral ischemia/reperfusion injury via the GluN2B-CaMKII-ERK1/2 pathway.
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Thioredoxin-1 and its mimetic peptide improve systolic cardiac function and remodeling after myocardial infarction.
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis.
NaAsO(2) regulates TLR4/MyD88/NF-κB signaling pathway through DNMT1/SOCS1 to cause apoptosis and inflammation in hepatic BRL-3A cells.
Understanding apoptotic induction by Sargentodoxa cuneata-Patrinia villosa herb pair via PI3K/AKT/mTOR signalling in colorectal cancer cells using network pharmacology and cellular studies.
Neuroprotective Effect of Zishen Huoxue Decoction treatment on Vascular Dementia by activating PINK1/Parkin mediated Mitophagy in the Hippocampal CA1 Region.
Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis.
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling.
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1.
Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.
Discovery of Novel Marine-Derived Phidiandine/Lipoic Acid Hybrid as a Potential Anti-Atherosclerosis Agent: Design, Synthesis and in Vitro/in Vivo Evaluation.
The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization.
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Sulbactam protects neurons against double neurotoxicity of amyloid beta and glutamate load by upregulating glial glutamate transporter 1.
Tetrandrine downregulates TRPV2 expression to ameliorate myocardial ischemia/reperfusion injury in rats via regulation of cardiomyocyte apoptosis, calcium homeostasis and mitochondrial function.
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling.
Complanatuside A improves functional recovery after spinal cord injury through inhibiting JNK signaling-mediated microglial activation.
DPY30 knockdown suppresses colorectal carcinoma progression via inducing Raf1/MST2-mediated apoptosis.
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.
Inhibition of XPR1-dependent phosphate efflux induces mitochondrial dysfunction: A potential molecular target therapy for hepatocellular carcinoma?
Amitraz mechanisms of cytotoxicity in a characterized SH-SY5Y cells spheroid model.
Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells.
FL118: A potential bladder cancer therapeutic compound targeting H2A.X identified through library screening.
Exploring the mechanism of carbamazepine decreasing testosterone levels based on cAMP/PKA/CREB pathway.
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.
Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study.
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Protective effect of metformin on the NG-nitro-l-arginine methyl ester (l-NAME)-induced rat models of preeclampsia.
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway.
FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.
Butyrolactone-I from Marine Fungal Metabolites Mitigates Heat-Stress-Induced Apoptosis in IPEC-J2 Cells and Mice Through the ROS/PERK/CHOP Signaling Pathway.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
A novel recombinant adenovirus expressing apoptin and melittin genes kills hepatocellular carcinoma cells and inhibits the growth of ectopic tumor.
Neuroprotective effects of exosomes derived from bone marrow mesenchymal stem cells treated by Musk Ketone on ischemic stroke.
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway.
Donor-Acceptor-Donor Strategy Rouses the Photodynamic Therapy Anticancer Activity of a Bis-terpyridyl Ru(II) Complex.
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring.
Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence.
Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis.
Emodin attenuates hypoxic-ischemic brain damage by inhibiting neuronal apoptosis in neonatal mice.
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis.
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model.
Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway.
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway.
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition.
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Blockage of S100A8/A9 ameliorates septic nephropathy in mice.
Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE(-/-) mice with minimal side effects.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells.
Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells.
Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway.
Protective effect of Platycodon grandiflorus polysaccharide on apoptosis and mitochondrial damage induced by pseudorabies virus in PK-15 cells.
Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells.
The long noncoding RNA CIRBIL is a regulator of steroidogenesis in mice.
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.
Carbon Monoxide Releasing Molecule-3 Alleviates Oxidative Stress and Apoptosis in Selenite-Induced Cataract in Rats via Activating Nrf2/HO-1 Pathway.
Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis.
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1/Foxo3a pathway.
Effects of iguratimod on inflammatory factors and apoptosis of submandibular gland epithelial cells in NOD mice.
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.
Metformin alleviates cerebral ischemia/reperfusion injury aggravated by hyperglycemia via regulating AMPK/ULK1/PINK1/Parkin pathway-mediated mitophagy and apoptosis.
Reactive oxygen species-mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force.
Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice.
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis.
IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A.
A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.
Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome.
DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK.
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Virulence assessment of four Glaesserella parasuis strains isolated in Liaoning province of China.
Expression of αA-crystallin (CRYAA) in vivo and in vitro models of age-related cataract and the effect of its silencing on HLEB3 cells.
Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway.
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Mass spectrometry-based metabolomics reveal Dendrobium huoshanense polysaccharide effects and potential mechanism of N-methyl-N'-nitro-N-nitrosoguanidine -induced damage in GES-1 cells.
Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer.
Nicotinamide Mononucleotide Adenylyl Transferase 2 Inhibition Aggravates Neurological Damage after Traumatic Brain Injury in a Rat Model.
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
TFP5 attenuates cyclin-dependent kinase 5-mediated islet β-cell damage in diabetes.
Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury.
Lysophosphatidic acid is associated with oocyte maturation by enhancing autophagy via PI3K-AKT-mTOR signaling pathway in granulosa cells.
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling.
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins.
Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer.
Renal transporter OAT1 and PPAR-α pathway co-contribute to icaritin-induced nephrotoxicity.
PM2.5 exposure exacerbates mice thoracic aortic aneurysm and dissection by inducing smooth muscle cell apoptosis via the MAPK pathway.
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy.
ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats.
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay.
YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice.
Spinal cord tissue engineering via covalent interaction between biomaterials and cells.
METTL3 depletion contributes to tumour progression and drug resistance via N6 methyladenosine-dependent mechanism in HR+HER2-breast cancer.
MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells.
Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.
Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway.
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery.
hsa-miR-1301-3p Promotes the Proliferation and Migration of Nonsmall Cell Lung Cancer Cells and Reduces Radiosensitivity via Targeting Homeodomain-Only Protein Homeobox.
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
OGG1 aggravates renal ischemia-reperfusion injury by repressing PINK1-mediated mitophagy.
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1.
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.
Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN.
MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage.
Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury.
Continuous Monochromatic Blue Light Exacerbates High-Fat Diet-Induced Kidney Injury via Corticosterone-Mediated Oxidative Stress.
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Anti-melanoma effect and action mechanism of a novel chitosan-based composite hydrogel containing hydroxyapatite nanoparticles.
Integrated Bioinformatic Analysis Reveals TXNRD1 as a Novel Biomarker and Potential Therapeutic Target in Idiopathic Pulmonary Arterial Hypertension.
Systemically Silencing Long Non-coding RNAs Maclpil With Short Interfering RNA Nanoparticles Alleviates Experimental Ischemic Stroke by Promoting Macrophage Apoptosis and Anti-inflammatory Activation.
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation.
Pretreatment with Shenmai Injection Protects against Coronary Microvascular Dysfunction.
Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts.
The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury.
Calycosin Improves Intestinal Mucosal Barrier Function after Gastrectomy in Rats through Alleviating Bacterial Translocation, Inflammation, and Oxidative Stress.
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.
Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation.
Overexpression of Aquaporin-3 Alleviates Hyperosmolarity-Induced Nucleus Pulposus Cell Apoptosis via Regulating the ERK1/2 Pathway.
Hugan Buzure Induces Autophagy and Apoptosis in Hepatocellular Carcinoma by Inhibiting PI3K/Akt/mTOR Signaling Pathway.
Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice.
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease.
Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death.
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction.
LncRNA PCAT19 induced by SP1 and acted as oncogene in gastric cancer competitively binding to miR429 and upregulating DHX9.
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β.
Sinomenine Confers Protection Against Myocardial Ischemia Reperfusion Injury by Preventing Oxidative Stress, Cellular Apoptosis, and Inflammation.
SIRT1 Is Involved in the Neuroprotection of Pterostilbene Against Amyloid β 25-35-Induced Cognitive Deficits in Mice.
Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From Scutellaria barbata D. Don.
Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction.
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
TRIM38 protects H9c2 cells from hypoxia/reoxygenation injury via the TRAF6/TAK1/NF-κB signalling pathway.
Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Trehalose improves palmitic acid-induced apoptosis of osteoblasts by regulating SIRT3-medicated autophagy via the AMPK/mTOR/ULK1 pathway.
Ursolic acid inhibits the activation of smoothened-independent non-canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade.
Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats.
Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents.
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury.
TFAP2C Knockdown Sensitizes Bladder Cancer Cells to Cisplatin Treatment via Regulation of EGFR and NF-κB.
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress.
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Fucoxanthin induces apoptosis and reverses epithelial-mesenchymal transition via inhibiting Wnt/β-catenin pathway in lung adenocarcinoma.
Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass.
The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.
Effect of muscone on anti-apoptotic ability of muskrat prostate primary cells.
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells.
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Pt(IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity.
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Bioactive substances in the stratum corneum of the epidermis found as indicators of skin damage due to sun exposure.
Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma.
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway.
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Leonurine Protects Bone Mesenchymal Stem Cells from Oxidative Stress by Activating Mitophagy through PI3K/Akt/mTOR Pathway.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
miR-125b Disrupts Mitochondrial Dynamics via Targeting Mitofusin 1 in Cisplatin-Induced Acute Kidney Injury.
Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system.
Effects of Ganfule capsule on microbial and metabolic profiles in anti-hepatocellular carcinoma.
Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Methylmercury induces lysosomal membrane permeabilization through JNK-activated Bax lysosomal translocation in neuronal cells.
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts.
LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy.
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.
Limosilactobacillus reuteri SLZX19-12 Protects the Colon from Infection by Enhancing Stability of the Gut Microbiota and Barrier Integrity and Reducing Inflammation.
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Acrylonitrile exposure triggers ovarian inflammation and decreases oocyte quality probably via mitochondrial dysfunction induced apoptosis in mice.
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway.
Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1.
Ophiopogonin D'-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells.
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells.
Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H(2)O(2) enhances their ability to treat intervertebral disc degeneration.
HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance.
Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.
Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway.
Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: in vitro and in vivo studies.
2-PMAP Ameliorates Cerebral Vasospasm and Brain Injury after Subarachnoid Hemorrhage by Regulating Neuro-Inflammation in Rats.
Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo.
Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways.
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII.
PRUNE2 inhibits progression of colorectal cancer in vitro and in vivo.
Cardiotoxicity of patulin was found in H9c2 cells.
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
miR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2.
Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner.
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1.
Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice.
IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat Orthotopic Liver Transplantation Model.
Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact.
Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin.
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.
Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway.
Breaking the Iron Homeostasis: A "Trojan Horse" Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition.
Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.
CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury.
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.
GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts.
CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.
Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway.
CTRP1 Attenuates Cerebral Ischemia/Reperfusion Injury via the PERK Signaling Pathway.
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway.
Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure.
Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling.
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Erteng-Sanjie Capsule Enhances Chemosensitivity of 5-Fluorouracil in Tumor-Bearing Nude Mice with Gastric Cancer by Inhibiting Notch1/Hes1 Signaling Pathway.
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Wenxin Granules Regulate Endoplasmic Reticulum Stress Unfolded Protein Response and Improve Ventricular Remodeling on Rats with Myocardial Infarction.
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Qingda granule exerts neuroprotective effects against ischemia/reperfusion-induced cerebral injury via lncRNA GAS5/miR-137 signaling pathway.
Hyperbaric Oxygen Therapy Attenuates Burn-Induced Denervated Muscle Atrophy.
Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study.
Inhibition of mu-opioid receptor suppresses proliferation of hepatocellular carcinoma cells via CD147-p53-MAPK cascade signaling pathway.
The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.
Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells.
MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects.
Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells.
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Kaempferol Ameliorates the Inhibitory Activity of Dexamethasone in the Osteogenesis of MC3T3-E1 Cells by JNK and p38-MAPK Pathways.
miR-25 Regulates Gastric Cancer Cell Growth and Apoptosis by Targeting EGR2.
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I.
Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure.
Hydroxychloroquine alleviates the neurotoxicity induced by anti-ribosomal P antibodies.
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90.
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Metformin attenuates H(2)O(2)-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway.
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer.
The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
Methylation gene KCNC1 is associated with overall survival in patients with seminoma.
Toxicological and physiological effects of successive exposure to ochratoxin A at food regulatory limits.
Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway.
Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis.
Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-dependent manner to regulate autophagy and inflammation.
HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation.
G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer.
Histone deacetylase 10 exerts anti-tumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis.
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Structural analysis of Panax ginseng glycoproteins and its anti-oligoasthenozoospermia effect in vivo.
Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway.
Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
miR-101-3p sensitizes lung adenocarcinoma cells to irradiation via targeting BIRC5.
Dracomolphin A-E, new lignans from Dracocephalum moldavica.
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo.
AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress.
Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression.
Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway.
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibiting VEGF production.
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents.
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway.
Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury.
Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.
Epigenetic upregulation of HOXC10 in non-small lung cancer cells.
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Anti-CD19 mAb-conjugated human serum albumin nanoparticles effectively deliver doxorubicin to B-lymphoblastic leukemia cells.
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway.
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
NFIB functions as an oncogene in estrogen receptor-positive breast cancer and is regulated by miR-205-5p.
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury.
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.
Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice.
Tamibarotene Improves Hippocampus Injury Induced by Focal Cerebral Ischemia-Reperfusion via Modulating PI3K/Akt Pathway in Rats.
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1.
The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation.
DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells.
UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway.
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells.
A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.
Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke.
Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage.
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.
Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis.
Effects of dimethyl carbonate-induced autophagic activation on follicular development in the mouse ovary.
Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes.
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3.
Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition.
Jiang Z, Ye X, Song M, Qiao Y, Cheng W, Wang D, Zhang X, Li X, Yu X, Wang X, Ji J, Mou Y
Nucleosides, nucleotides & nucleic acids 2026;45(1):64-87
Nucleosides, nucleotides & nucleic acids 2026;45(1):64-87
Novel Small Molecule DZ-865B Effectively Degrades BCL6, Promotes Apoptosis and Reduces Proliferation of Diffuse Large B-Cell Lymphoma Cells.
Wang Y, Chen X, Yin Y, Li T, Chen J
Oncology research 2026;34(3):23
Oncology research 2026;34(3):23
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells.
Lin H, Wei J, Yao W, Zhang Q, Jin J
Frontiers in pharmacology 2026;17:1739226
Frontiers in pharmacology 2026;17:1739226
Reactive oxygen species/hypoxia dual-responsive polymers combined with melatonin inhibited PANoptosis of retinal ganglion cells for acute glaucoma treatment.
Meng S, Fang W, Wu Y, Xia Z, Chou T, Xia Y, Ding L, Zhou X, Xia X
Theranostics 2026;16(2):830-851
Theranostics 2026;16(2):830-851
Monitoring early micro-oxidation under refrigeration: iron and oxidative markers predict quality loss in grass carp.
Xiong X, Feng R, Zhang H, Ding N, Zhuang S, Tan Y, Ma H, Hong H, Luo Y
Current research in food science 2026;12:101307
Current research in food science 2026;12:101307
Seminal plasma extracellular vesicle-derived miR-296-3p targets PLA2G6 to enhance boar sperm motility by lowering Lys Phosphatidylcholine.
Zhao K, An Y, Zhang Y, Zhang J, Li H, Wang J, Yao Z, Wang T, Chen L, Chen X, Jin Y
Animal reproduction science 2026 May;288:108135
Animal reproduction science 2026 May;288:108135
8-Oxoguanine modifications in seed regions of miRNAs regulating P16 promote aging by reshaping gene regulatory networks.
Guo JQ, Wang QY, Zhang YM, Li J, Yang L, Zhang X, Han MM, Xi H, Qi RM, Cai JP
Free radical biology & medicine 2026 May;248:301-319
Free radical biology & medicine 2026 May;248:301-319
Saikosaponin D alleviates chronic prostatitis/chronic pelvic pain syndrome by regulating the NF-κB pathway via lncRNA5682.
Wang X, Zang Z, Zhou Y, Liu Z, Zhang H, Zhang K, Wang Z, Fu Q
Journal of ethnopharmacology 2026 May 23;363:121384
Journal of ethnopharmacology 2026 May 23;363:121384
FXR-mediated transcriptional regulation of KLF11 mitigates contrast-induced acute kidney injury via suppressing JAK2/STAT3 pathway.
Su BW, Yang HX, Wang WH, Wen L, Cui XH, Bao YN, Ren HW, Wang GY, Hu WJ, Yuan RQ, Wen RK, Luan ZL
International immunopharmacology 2026 May 15;177:116494
International immunopharmacology 2026 May 15;177:116494
The role of nGPx4 in resisting DEHP-induced DNA damage and reducing caspase-independent cell death in male germ cells.
Gu W, Wang J, Liu X, Tan H, Yang H, Zhu Z, Ran P, Ling Q, Mao W
Clinical and experimental reproductive medicine 2026 Mar;53(1):77-96
Clinical and experimental reproductive medicine 2026 Mar;53(1):77-96
A Brain-Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF-β1/PI3K-AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses.
Han Z, Li X, Zhu Y, Wang Z, Hou Y, Tao H, Ma M, Xie X, Zhang H
Journal of cellular and molecular medicine 2026 Mar;30(5):e71065
Journal of cellular and molecular medicine 2026 Mar;30(5):e71065
Biomineralized Bacterial Biohybrid for Coordinated and Self-Sustained In Situ Synthesis of Antitumor Photothermal Agent and Photosensitizer.
Jin K, Zhang Y, Huang Y, Yu L, Zhong Y, Niu L, Wu Y
Advanced healthcare materials 2026 Mar;15(10):e04077
Advanced healthcare materials 2026 Mar;15(10):e04077
Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.
Yang T, Gao Z, Huang H, Zhang C, Tang Y, Qu Q, Li H, Ke J, Chen Z, Feng M, Zhou H, Shu Y, Yuan W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e14269
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(18):e14269
Targeting CCNB1 Repressed Cartilage Degradation Induced by Inflammation Through NF-κB Pathway in Osteoarthritis.
Li H, Qiao Y, Ding M, Liu Y
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2026 Mar-Apr;74(2):235-248
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2026 Mar-Apr;74(2):235-248
Zearalenone Induces Oxidative Stress and Apoptosis in the Jejunum of Weaned Piglets via the p53/Nrf2 Signaling Pathway.
Sang Y, Hou S, Zhang Z, Jiang S, Yang W, Cheng Q
International journal of molecular sciences 2026 Mar 5;27(5)
International journal of molecular sciences 2026 Mar 5;27(5)
The CDO1-ACSM3 Axis Mediates Renal Tubule Lipid Deposition and Injury by Causing Mitochondrial Dysfunction in Lupus Nephritis.
Zhang Z, Liu J, Liu Y, Wang L, Li Z, Dong Y, Tian Y, Miao X, Liu Q, Zhang W, Guo H, Xing L, Yang L, Feng X, Liu S
Cells 2026 Mar 4;15(5)
Cells 2026 Mar 4;15(5)
CSF1 regulates inflammation and apoptosis in intervertebral disc degeneration.
Zhang F, Wu W, Yuan Y, Wang Y, Zhang W
Scientific reports 2026 Mar 30;16(1)
Scientific reports 2026 Mar 30;16(1)
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Chen Z, Sun C, Wang Y, Duan X, Ma H, Zhou X, Chen S, Peng P
iScience 2026 Mar 20;29(3):114927
iScience 2026 Mar 20;29(3):114927
Thioredoxin protects against diabetic hearing loss by regulating TOMM22 mediated mitochondrial autophagy in hair cells and inhibiting microglial M1 polarization.
Zhong S, Xu M, Wang Q, Wang S, Li X, Guo Y, Kong H
Scientific reports 2026 Mar 20;16(1)
Scientific reports 2026 Mar 20;16(1)
Nobiletin enhances Doxorubicin sensitivity in osteosarcoma through ER stress-induced apoptosis mediated by the PI3K/AKT pathway.
Liu F, Yuan D, Zhang Z, Gong R, Jin X, Wang C, Xie W, Zhang Y
Scientific reports 2026 Mar 19;16(1)
Scientific reports 2026 Mar 19;16(1)
Ferulic Acid Alleviates Chemotherapy-Induced POI by Targeting the Grp78 and Perk-eIF2α-ATF4-CHOP Pathway to Attenuate Endoplasmic Reticulum Stress.
Li F, Huang Y, Liu Z, Geng Y, Hu R, Song Y, Xu L, Zhang M
Biomedicines 2026 Mar 19;14(3)
Biomedicines 2026 Mar 19;14(3)
Modulating GRP75 to restore calcium homeostasis: a novel neuroprotective strategy of CRSE6(#) in Parkinson's disease models.
Wang X, Li S, Xiang X, Zhang X, Yu C, Qing D, Law BY, Tang Y
Journal of advanced research 2026 Mar 19;
Journal of advanced research 2026 Mar 19;
A Dual-Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor-Associated Osteolysis Restoration via Sequential Release.
Liu L, Liu HZ, Liu ZN, Wang T, Yu LL, Li QJ, Chen ZY, Luo GF, Shang ZJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e18962
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 18;:e18962
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
Zhao H, Meng L, Du P, Chen Y, Gong M, Zan B, Chen J, Zeng M, Liao Y
Journal of nanobiotechnology 2026 Mar 16;
Journal of nanobiotechnology 2026 Mar 16;
Capicua mediates interleukin-2 withdrawal-induced death of activated CD8(+) T cells.
Shi JG, Xu Y, Hang WH, Zhang XY, Ma ZW, Li S
Cell insight 2026 Jun;5(3):100323
Cell insight 2026 Jun;5(3):100323
Salvia miltiorrhiza extract attenuates cardiorenal syndrome by inhibiting IL-1β mediated cross-talk between heart and kidney.
Wang M, Bai JQ, Cai J, Chen QQ, Wen XD, Qi LW, Zhang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158060
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158060
Design and synthesis of dual mitochondria-targeted biguanide derivatives as potential anticancer agents.
Ning Y, Yang X, Chen L, Yi J, Li J, Lin Y, Mu L, Xu C
Bioorganic chemistry 2026 Jul 15;176:109847
Bioorganic chemistry 2026 Jul 15;176:109847
The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.
Sha C, Pan F, Liu X, Wang Z, Dai H, Huang K
Journal of orthopaedic translation 2026 Jan;56:101016
Journal of orthopaedic translation 2026 Jan;56:101016
CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis.
Luo X, Xu L, Cai J, Ma S, Song H, Yang P, Yang C
Journal of orthopaedic translation 2026 Jan;56:101005
Journal of orthopaedic translation 2026 Jan;56:101005
Poria cocos polysaccharide inhibits Porcine Deltacoronavirus replication in vitro through regulating apoptosis by PI3K-Akt/NF-κB signaling pathway.
Sun M, Yang J, Liang Y, Deng X, Hong Y, Wen Y, Wang Y, Wu R, Zhao Q, Du S, Yan Q, Cao S, Huang X
Microbial pathogenesis 2026 Jan;210:108188
Microbial pathogenesis 2026 Jan;210:108188
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein.
Wang C, Liang D, Shen X, Chen X, Lai L, Hou H
British journal of pharmacology 2026 Jan;183(1):153-170
British journal of pharmacology 2026 Jan;183(1):153-170
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Li C, Liu C, Xia Y, Liu X, Wang F, Zhuo G, Ren Q
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
PIEZO1 Mediates Apoptosis of Endothelial Cells via Enhancing HMGA2 Expression Under Simulated Microgravity.
Wang Y, Wang R, Qin X, Pan Y, Li C, Sun X
International journal of molecular sciences 2026 Jan 30;27(3)
International journal of molecular sciences 2026 Jan 30;27(3)
α-terpineol induces apoptosis in melanoma cells and its underlying mechanism.
Liu W, Xiao Y, Zan X, Qi J, Ma T, Long Q, Wu B, Cao Y
Scientific reports 2026 Jan 3;16(1):4278
Scientific reports 2026 Jan 3;16(1):4278
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Li Q, Chen L, Sun Y, Wang C, Sun Y, Lu K, Li L, Sun H, Liu M
Journal of nanobiotechnology 2026 Jan 29;24(1)
Journal of nanobiotechnology 2026 Jan 29;24(1)
Unsymmetrical dimethylhydrazine induces dose-dependent liver toxicity in rats via oxidative stress and PI3K/Akt pathway-mediated apoptosis.
Zheng J, Wu L, Duan X, Ding W, Zhou J, Zhou S, Wu D, Li H
Chemico-biological interactions 2026 Jan 25;424:111852
Chemico-biological interactions 2026 Jan 25;424:111852
MTP18 as a prognostic biomarker and therapeutic target in lung adenocarcinoma.
Li Q, Tang Y, Su H, Zhou Y, Wang T, Shi J
Respiratory research 2026 Jan 20;27(1):63
Respiratory research 2026 Jan 20;27(1):63
TRV130 inhibits colon cancer progression via suppressing the Hedgehog signaling pathway: in vitro and in vivo evidence.
Zhuang Y, Jiang C, Guo Y, Sun J
Hereditas 2026 Jan 19;163(1):26
Hereditas 2026 Jan 19;163(1):26
Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy.
Xie X, Liu C, Liu X, Hou L, Zhang Y, Huang L, Peng W, Liu Y
Scientific reports 2026 Jan 13;16(1):5155
Scientific reports 2026 Jan 13;16(1):5155
Nucleophosmin Promotes Regulated Cell Death in Podocyte Injury.
Urae S, Wang Z, Kumar S, Chen HA, Henderson JM, Beck LH Jr,, Borkan SC
Kidney360 2026 Jan 1;7(1):35-48
Kidney360 2026 Jan 1;7(1):35-48
Transcriptomics-guided high-throughput drug screening identifies potent therapies for P53 pathway altered DIPG/DMG.
Jiang Z, Xie L, Zhou H, Geng Y, Xiao X, Li T, Deng Y, Zhang M, Shan S, Xu C, Zhang L
Neuro-oncology 2026 Jan 1;28(1):251-267
Neuro-oncology 2026 Jan 1;28(1):251-267
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Zheng R, Liu Y, Zhou S, Liu G, Liu X, Yang Y, Zhang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
Intranasal triptolide in mice: a strategy to reduce neuroinflammation and boost cognitive function.
Yan M, Zhang L, Zhao J, Ge Y, Hu K, Zhang Z, Zhu X, Wu X, Zhang Z, Zeng H
Immunopharmacology and immunotoxicology 2026 Feb;48(1):79-93
Immunopharmacology and immunotoxicology 2026 Feb;48(1):79-93
γ-Glutamylcysteine Alleviates t-BHP-Induced Oxidative Damage in NIH/3T3 Fibroblasts by Promoting Nuclear Translocation of Nrf2.
Lu S, Pan Y, Xia M, Luo J, Yu W
Food science & nutrition 2026 Feb;14(2):e71574
Food science & nutrition 2026 Feb;14(2):e71574
Lycium barbarum polysaccharides enhance testicular spermatogenesis in d-galactose-induced aging rats via calcium signaling.
Ma W, Liu C, Pu J, Liu Z, Hu N, Yang L, Chen D, Li H, Ma H
Andrology 2026 Feb;14(2):496-515
Andrology 2026 Feb;14(2):496-515
Acute sleep deprivation reduces thermotolerance and exacerbates heat stroke via disruption of intestinal barrier integrity in rats.
Li L, Xie Y, Gong Y, Chen J, Wang Y, Pei Y, Zhou J, You J, Cao Y, Song M, Sun H, Ma W, Wang M, Ma J, Chen J, Chang W, Song Q, Wang Y, Wang Q, Xu S
Sleep medicine 2026 Feb;138:108699
Sleep medicine 2026 Feb;138:108699
Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia-Reperfusion Injury.
Cheng X, Liu S, Zhang Y, Peng K, Qile M, Wu C, Dou M, Liu L, Yang N, Liu R, Zhang G, Ni L, Liang G, Yang F, Zhang Y, He S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(11):e20852
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(11):e20852
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
Wang X, Xue P, Zhang J, Jin H, Jiang J, Xu G, Cui Z
Journal of molecular histology 2026 Feb 25;57(2)
Journal of molecular histology 2026 Feb 25;57(2)
ZIKV envelope protein is a strong blocker of early directional differentiation in the neural lineage.
Ma ZH, Wang Y, Hassaan NA, Chu XN, Wang PH, Wu C, Xing L
Communications biology 2026 Feb 10;9(1)
Communications biology 2026 Feb 10;9(1)
Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.
Zhang J, Ding M, Luo L, Huang D, Li S, Chen S, Fan Y, Liu L, Xie H, Liu G, Yu K, Wu J, Xiao X, Wu Y
Neural regeneration research 2026 Aug 1;21(8):3598-3608
Neural regeneration research 2026 Aug 1;21(8):3598-3608
Photobiomodulation therapy inhibits ISO-induced myocardial remodeling in mice through modulating TGF-β/Smad7 and PI3K/AKT pathways.
Jiang Y, Xu Z, Sun X, Sun S, Ding K, Li J, Chu W, Chang J, Sun W, Shi L
Photodiagnosis and photodynamic therapy 2026 Apr;58:105389
Photodiagnosis and photodynamic therapy 2026 Apr;58:105389
Retigabine ameliorates CRS-induced depressive-like behaviors and cognitive impairment by inhibiting endoplasmic reticulum stress-mediated apoptosis.
Zhang J, Li YH, Zhang JJ, Chen SB, Zhan JQ, Wei B, Hu J
Brain research bulletin 2026 Apr;237:111798
Brain research bulletin 2026 Apr;237:111798
Remimazolam Ameliorates Autistic-Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD.
Zhang Y, Lin J, Tong C, Fu X, Shan M, Huang Y, Zhang K, Zheng J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e08520
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e08520
Lysosome-targeted degradation of leucine-rich alpha-2 glycoprotein 1 enables chemosensitization to 5-fluorouracil in colorectal cancer.
Wu G, Zhang K, Min H, Du L, Li J, Li W, Zhang Y, Du S, Qi Y, Zhang W
Journal of controlled release : official journal of the Controlled Release Society 2026 Apr 28;395:114962
Journal of controlled release : official journal of the Controlled Release Society 2026 Apr 28;395:114962
Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model.
Yu Y, Du J, Li B, Cheng Y, Lin F, Zhou J, Song Y, Liu C, Cai S
iScience 2026 Apr 17;29(4):115027
iScience 2026 Apr 17;29(4):115027
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.
Liu W, Zheng YN, Jiang S, Ren S, Tang S, Zhang J, Wang Z, Li W
Current medicinal chemistry 2025;32(14):2809-2823
Current medicinal chemistry 2025;32(14):2809-2823
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis.
Fang Q, Yan Q, Liu X, Zhang X, Zha L, Zhang R, Gao Z, Du J, Chen L
International journal of biological sciences 2025;21(3):1294-1307
International journal of biological sciences 2025;21(3):1294-1307
Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.
Li C, Wen J, Wang L, Lei J, Lin Z, Zou Y, Cheng J, Wan X, Liu J, Wu J
International journal of biological sciences 2025;21(1):175-188
International journal of biological sciences 2025;21(1):175-188
Identification and Functional Characterization of a Novel PRPS1 Variant in X-Linked Nonsyndromic Hearing Loss: Insights From Zebrafish and Cellular Models.
Wan Y, Li J, Guo Y, Guo F, Zhao Y, Li Y, Yang X, Chen H, Xie S, Wang M, Guan G, Zhu Y, Li X
Human mutation 2025;2025:6690588
Human mutation 2025;2025:6690588
The protective influence of Astragalus on rat models of preeclampsia.
Yang L, Hao H, Zhang X, Ren X, Xu M, Zhang N, Zhang Y, Yang H
PloS one 2025;20(12):e0337583
PloS one 2025;20(12):e0337583
Multi-Focused Acoustic Radiation Force Impulse Modulation of Murine Hepatic Xenografts Enhances Nanoscale DOX@Lip Delivery and Therapeutic Effect.
Wu S, Wang C
International journal of nanomedicine 2025;20:7359-7373
International journal of nanomedicine 2025;20:7359-7373
Leonurine Attenuates CCl(4)-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.
Wang P, Bai J, Ye M, Huang Z, Chen J, Sun L, Zhong X, Zheng Y, Ma T, Fu W, Du Y
Drug design, development and therapy 2025;19:6553-6571
Drug design, development and therapy 2025;19:6553-6571
Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway.
Dong T, Li J, Liang X, Wang W, Chen M, Yang G, Wu D
Drug design, development and therapy 2025;19:569-583
Drug design, development and therapy 2025;19:569-583
Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway.
Zhang Z, Yu X, Li J, Shen X, Fu W, Liu Y, Dong X, Wang Z
Drug design, development and therapy 2025;19:1067-1081
Drug design, development and therapy 2025;19:1067-1081
The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity.
Li Y, Lu S, Yao H, Zhu G, Liu H, Ma Z, Tang H
OncoTargets and therapy 2025;18:979-994
OncoTargets and therapy 2025;18:979-994
RBM39 Functions as a Potential Oncogene Through the NF-κB Signaling Pathway in Colorectal Cancer Cells.
Wang Y, Yang X, Yang Z, Chen Z, Jiang H, Wang Y, Shen D, Su G
Journal of Cancer 2025;16(7):2233-2249
Journal of Cancer 2025;16(7):2233-2249
Eupalinolide A inhibits cancer progression and induces ferroptosis and apoptosis by targeting the AMPK/mTOR/SCD1 signalling in non-small cell lung cancer.
Zhang Y, Wang C, Zhang X, Chen D, Ren Z, Yang H, Wang N, Tang Z, Long X, Zhao L, Zhou N, Zhang J, Li L, Hu C, Wang F, Tang J, Kang F, Pan L, Wei Y
Frontiers in pharmacology 2025;16:1649314
Frontiers in pharmacology 2025;16:1649314
Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments.
Guo DQ, Fang YM, Sun ZD, Zeng YF, Wang GD, Liang JW
Frontiers in pharmacology 2025;16:1636576
Frontiers in pharmacology 2025;16:1636576
Chinese massage therapy (Tuina) inhibits motor neuron apoptosis in rats with sciatic nerve injury by regulating the cPLA2 and RhoA/ROCK2 signaling pathways.
Sun J, Zhang Y, Liu Z, Zhang H, Liu J, Xu Y, Na R, Zhang H, Yan J, Yu T
Frontiers in neurology 2025;16:1622602
Frontiers in neurology 2025;16:1622602
Protective effects of Atractylodes macrocephala polysaccharides on acetaminophen-induced liver injury.
Wu J, Jia B, Gong S, Li Y, Wang J, Huang Y, Guo J
Frontiers in pharmacology 2025;16:1583334
Frontiers in pharmacology 2025;16:1583334
Identification of immune subtypes associated with CD8+ T cell-related genes providing new treatment strategies of esophageal carcinoma.
Wu Y, Lin C, Qian Y, Huang X, Xu Y, Li J, He Y, Xie C, Su H
Frontiers in immunology 2025;16:1512230
Frontiers in immunology 2025;16:1512230
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing.
Xiao Y, Shi Z, Yuan Y, Yao D, Feng R, Zhang Y, Zhao D, Zhang H, Sun P, Liu Y, Li Y, Shen X, Wang Z, Hu D, Guan H, Wang H
Theranostics 2025;15(18):9862-9884
Theranostics 2025;15(18):9862-9884
Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model.
Dawa ZM, Zhai T, Liu CC, Fan HN
Frontiers in medicine 2025;12:1503472
Frontiers in medicine 2025;12:1503472
Discovery of active compounds in Danshen-Chuanxiong formula for blood-brain barrier protection: a multi-parametric study using an OGD/R-induced spheroid model.
Zhou Y, Li Y, Yang Z, Zhao L, Wang Y
Journal of natural medicines 2025 Sep;79(5):1122-1139
Journal of natural medicines 2025 Sep;79(5):1122-1139
A novel synthesised STAT3 inhibitor exerts potent anti-tumour activity by inducing lysosome-dependent cell death.
Xu MX, Liu X, Zhang HL, Xu H, Ma X, Yang Y, Duan C, Tang S, Liu Y, Li C, Pei M, Xia J, Yang Y, Guo Y, Wang Y, Luo S, Ma J, Yang Z, Zhu XF, Xu CP
British journal of pharmacology 2025 Sep;182(17):4041-4057
British journal of pharmacology 2025 Sep;182(17):4041-4057
New cardiac glycosides from Adonis amurensis with potent antitumor activity.
Yan Y, Fang J, Lou Y, Zhou D, Wang Y, Wang N, Chen Z, Li N
Bioorganic chemistry 2025 Sep;164:108887
Bioorganic chemistry 2025 Sep;164:108887
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
Tang Z, Zheng Y
Cells 2025 Sep 4;14(17)
Cells 2025 Sep 4;14(17)
Role of RET-Regulated GDNF-GFRα1 Endocytosis in Methamphetamine-Induced Neurotoxicity.
Lv M, Shen B, Wu Z, Yang G, Cao Y, Zhang Y, Shu J, Dong W, Hou Z, Jing D, Zhang X, Hou Y, Xu J, Li L, Hong S
International journal of molecular sciences 2025 Sep 29;26(19)
International journal of molecular sciences 2025 Sep 29;26(19)
BAP31 represses endoplasmic reticulum stress-mediated apoptosis and alleviates neurodegeneration in Parkinson's disease.
Qin Y, Chen Y, Chi M, Jia J, Wang L, Zhao Y, Wang Z, Zhou J, Yao J
Cell death & disease 2025 Sep 29;16(1):672
Cell death & disease 2025 Sep 29;16(1):672
Investigating C(7) modified tetrandrine derivatives for synthesis anti-hepatocellular carcinoma activity and mechanistic insights.
Jiang T, Shi L, Peng X, Zheng S, Chen Q, Lan J, Pan W
Scientific reports 2025 Sep 29;15(1):33601
Scientific reports 2025 Sep 29;15(1):33601
HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer models.
Zhang L, Liu S, Wang D, Zhang X, Hu Z, Zou X, Li X, Wang X, Xu D, Liu W, Liu B
Scientific reports 2025 Sep 29;15(1):33541
Scientific reports 2025 Sep 29;15(1):33541
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Wu B, Yang Z, Duan J, Chen Z, Xiao J, Luo Z, Jian G, Wang H, Lu G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
The BPIFA2 - LRP5 axis orchestrates mitochondrial dysfunction to mediate kidney injury in lupus nephritis.
Liu Y, Tian Y, Wang H, Li N, Zhuo R, Cui H, Miao X, Liu J, Liu Q, Zhang W, Guo H, Xing L, Yang L, Feng X, Liu S
International immunopharmacology 2025 Sep 23;162:115114
International immunopharmacology 2025 Sep 23;162:115114
High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy.
Sun X, Cai X, Li S, Pi R, Guo Z, Jiang J, Wang P, Xiong J, Liu Z, Rong Z, Yu Z, Zhang X, Chen J, Han D, Zhang Y, Tan J, Lin Y, Zou Z, Ai H, Kang F, Guo X, Dong Z, Wu D, Bai X
Cell reports. Medicine 2025 Sep 16;6(9):102291
Cell reports. Medicine 2025 Sep 16;6(9):102291
Nitrate Promotes the Survival of Diabetic Skin Flaps by Enhancing Autophagy Through the AMPK Signaling Pathway.
Li M, Zhu L, Xu Y, Han Z
The Journal of craniofacial surgery 2025 Sep 1;36(6):2127-2132
The Journal of craniofacial surgery 2025 Sep 1;36(6):2127-2132
10% carbon dioxide improves cognitive function after subarachnoid hemorrhage in rats: inhibiting neuronal apoptosis through the PI3K/AKT signaling pathway.
Tang L, Wen D, Huang Z, Lei X, Li X, Zhu Y, Hai S, Guo Z
Medical gas research 2025 Sep 1;15(3):391-397
Medical gas research 2025 Sep 1;15(3):391-397
Inorganic nitrate attenuates neuroinflammation after traumatic brain injury via Sialin.
Liu Z, Hu L, Wang Q, Zhao X, Liu W, Zhang B, Pan W, Song W, Chen X, Zhang C, Wang J, Wang S, Zhou J
Tissue & cell 2025 Oct;96:102955
Tissue & cell 2025 Oct;96:102955
Cadmium-induced apoptosis of granulosa cells is mediated by excessive activation of mitophagy and ROS-mediated mitochondrial dysfunction.
Li W, Wu M, Shi H, He M, Wang J, Huang Y, Xu D, Zhang J
Toxicology and applied pharmacology 2025 Oct;503:117462
Toxicology and applied pharmacology 2025 Oct;503:117462
Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.
Huang Z, Liu X, Zhou X, Chen K, Diao H, Wang M, Wei J, Li Z, Yang Y, Mao Z, Yu W
Aging cell 2025 Oct;24(10):e70203
Aging cell 2025 Oct;24(10):e70203
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury.
Wang S, Wang Y, Shan W, Li G, Yan R, Wang Z, Zhao Y, Yao J, Zhang N
British journal of pharmacology 2025 Oct;182(20):5023-5037
British journal of pharmacology 2025 Oct;182(20):5023-5037
Targeting c-Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple-negative breast cancer.
Liang X, Liu Y, Zhu Y, Zhao Y, Ye F, Gao F, Shi Y, Guan X
Clinical and translational medicine 2025 Oct;15(10):e70484
Clinical and translational medicine 2025 Oct;15(10):e70484
The protective role of quercetin in cataract lenses and its mechanisms related to the hippo signaling pathway.
Miao S, Feng Z
International ophthalmology 2025 Oct 9;45(1):409
International ophthalmology 2025 Oct 9;45(1):409
The Interventional Effects and Mechanisms of Lonidamine in Combination with Apigenin on Colorectal Cancer.
Zhou Y, Shi J, Zhang M, Yang H, Fei J
Current issues in molecular biology 2025 Oct 8;47(10)
Current issues in molecular biology 2025 Oct 8;47(10)
Luopan Mountain Pig Bone Marrow Mesenchymal Stem Cells Promote Liver Regeneration in D-Galactosamine-Induced Acute Liver Failure Rats by Regulating the PTEN-PI3K/Akt/mTOR Pathway.
Li M, Wang Z, Yan X, Liu Y, He Y, Zhang B, Guan W
Biology 2025 Oct 5;14(10)
Biology 2025 Oct 5;14(10)
1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons.
Zhou W, Liu Z, Qiu X, Tian M, He B, Tang C, Tang Q, Ye R, Zhong D, Liao Y
International immunopharmacology 2025 Oct 30;164:115400
International immunopharmacology 2025 Oct 30;164:115400
Empagliflozin-pretreated BMSC exosomes attenuate myocardial ischemia-reperfusion injury by enhancing atad3a/pink1-dependent mitophagy.
Jing Y, Cai Y, Li Q, Zheng Z, Yang H, Yu Y, Zhang C
Stem cell research & therapy 2025 Oct 29;16(1):595
Stem cell research & therapy 2025 Oct 29;16(1):595
PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells.
Zhou H, Sun S, Liu H, Li T, Xu Y, Yang R, Liu H, He L, Xu W, Guan S, Xu J
Antioxidants (Basel, Switzerland) 2025 Oct 11;14(10)
Antioxidants (Basel, Switzerland) 2025 Oct 11;14(10)
Ganfule capsule alleviates AFB1-induced toxic liver injury via inhibiting oxidative stress, inflammatory response, and apoptosis.
Li P, Cao Y, Hou Y, Zhang J, Zhang L, Li Z, Xu H, Zhang W, Zhao Z, Nie X, Hou J
Ecotoxicology and environmental safety 2025 Oct 1;304:119125
Ecotoxicology and environmental safety 2025 Oct 1;304:119125
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway.
Pan R, Jiang S, Su J, Zhang C, Li X, He K
Journal of physiology and biochemistry 2025 Nov;81(4):1173-1184
Journal of physiology and biochemistry 2025 Nov;81(4):1173-1184
RIPK4-p53 interaction drives aflatoxin B1-induced renal mitochondrial apoptosis via Ser15 phosphorylation: A CRISPR-Cas9 mechanistic study.
Ma Y, Zhao Q, Yuan J, Wang D, Chen X, Yu Y, Li J, Yu M, Yuan J, Lou J, Du S, Wen Y, Wang Y, Wu R, Yan QG, Huang X, Zheng Y, Zhao F, Cao SJ
International journal of biological macromolecules 2025 Nov;330(Pt 3):148130
International journal of biological macromolecules 2025 Nov;330(Pt 3):148130
Mechanistic insights into the Ganfule capsule in alleviating alcoholic liver disease.
Cao Y, Li P, Hou Y, Zhang L, Sun Y, Zhang J, Xu H, Li Z, Li S, Nie X, Hou J
Bioorganic chemistry 2025 Nov;166:109144
Bioorganic chemistry 2025 Nov;166:109144
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties.
Li C, Zhang Z, Luo C, Lan W, Liu C, Liu W, Xiang H, Yang J, Tang Y, Wang X
Journal of nanobiotechnology 2025 Nov 5;23(1):705
Journal of nanobiotechnology 2025 Nov 5;23(1):705
Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications.
Ding Y, Huang C, Yang G, Liu E, Wang Z, Su Y, Ge C
Journal of clinical and translational hepatology 2025 Nov 28;13(11):905-917
Journal of clinical and translational hepatology 2025 Nov 28;13(11):905-917
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Zhang C, Wang H, He Z, He J, Wang F, Yan S, Sheng Y, Yuan N, Chen Y, Xu X, Huang Y, Hu R, Wang M, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Mechanism of action of HuPoSan on EMs rats as revealed by multi-omics combined with network pharmacology.
Huo C, Li F, Guo L, Sun X, Guo Y, Chen X, Liu K, Wang C, Zhang C, Zhang W, Li J, Yang Y, Wang H, Zou X, Ma X, Zhai C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157480
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157480
Xiaoyao San and Guipi Tang, alone or combined, relieve postpartum depression via AGE‑RAGE‑mediated autophagy and apoptosis.
Li S, Guo Y, Zhang J, Zhang R, Li Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157338
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157338
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Han L, Tang Z, Ma X, Zhang Q, Han Y, Wang Q, Liu J, Bian X, Gao L, Xu M, Sun X
International journal of molecular sciences 2025 Nov 18;26(22)
International journal of molecular sciences 2025 Nov 18;26(22)
Knockdown of SUCLG2 inhibits glioblastoma proliferation and promotes apoptosis through LMNA acetylation and the mediation of H4K16la lactylation.
Li W, Zhang Q, Yin H, Li Q, Liu S, Wang J, Yuan G, Pan Y
Cell death discovery 2025 Nov 17;11(1):534
Cell death discovery 2025 Nov 17;11(1):534
Endoplasmic reticulum-mitochondria dual-targeting nanoplatform suppresses cancer stemness and enhances colorectal cancer immunotherapy.
Wang Y, Cheng W, Chen Y, Tian H, Huang C, Li K
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114230
Journal of controlled release : official journal of the Controlled Release Society 2025 Nov 10;387:114230
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
Duan WL, Wang XJ, Gu LH, Guo A, Ding YY, Lin P, Zhang BG
Cell death discovery 2025 Nov 10;11(1):520
Cell death discovery 2025 Nov 10;11(1):520
The effect of autophagy activation on apoptosis and myofibrillar structural proteins during the post-mortem storage of Esox lucius.
Fan X, Liu Y, Guo X, Wei Y, Liu P, Li H, Chen X, Deng X, Lei Y, Zhang J
Food chemistry 2025 Nov 1;491:145210
Food chemistry 2025 Nov 1;491:145210
2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis.
Chen M, Pang H, Pham TTH, He Y, Gao Q, Liao Y, Zhu C, Chen L, Yan G, Mo S, Han C
Toxicology and applied pharmacology 2025 May;498:117296
Toxicology and applied pharmacology 2025 May;498:117296
Dendrimer nanocarriers for targeted co-delivery of MiR-146b-3p and 5-ALA to synergistic photodynamic therapy in secondary hyperparathyroidism.
Wen Y, Zou Z, Li Y, Zhang D, Liu Z, Liu H, Li X, Wu W, Zeng L, Zou Q, Yi W
International journal of biological macromolecules 2025 May;310(Pt 1):143307
International journal of biological macromolecules 2025 May;310(Pt 1):143307
Hyaluronic acid/ε-polylysine hydrogel enriched with Saussurea involucrata polysaccharide for improved skin dryness induced by ultraviolet radiation.
Xu X, Huang X, Lin S, Yu G, Xiao J, Wang J, Song C, Khalilov F, Issaro N, Xu N, Gao S
International journal of biological macromolecules 2025 May;308(Pt 3):142718
International journal of biological macromolecules 2025 May;308(Pt 3):142718
Matrix metallopeptidase 2-responsive curcumin-loaded nanoparticles-induced signal transducer and activator of transcription 3 inhibition suppresses glioblastoma multiforme growth via enhancing nuclear factor erythroid 2-related factor 2 activity.
Jia F, Peng Y, Li X, Yang S, Xie Y, Han Y, Huang M, Liu T, Zou W, Chen L, Liang Z
International journal of biological macromolecules 2025 May;307(Pt 2):141998
International journal of biological macromolecules 2025 May;307(Pt 2):141998
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.
Luo A, Wang R, Gong J, Wang S, Yun C, Chen Z, Jiang Y, Liu X, Dai H, Liu H, Zheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2414960
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2414960
S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Zhao J, Zhou M, Yang C, Liu YW, Yang T, Sun B, Li B, Zheng J, Dai S, Yang Z, Wang X
Biomarker research 2025 May 9;13(1):72
Biomarker research 2025 May 9;13(1):72
Compound probiotics alleviate hyperuricemia-induced renal injury via restoring gut microbiota and metabolism.
Liu P, Hu P, Jin M, Sun W, Wu J, Tang Y, Shi D, Xie T, Tong Y, Huang L, Zhang D, Zheng H, Xu X, He H
BMC microbiology 2025 May 8;25(1):280
BMC microbiology 2025 May 8;25(1):280
Liquiritigenin protects against cadmium-induced testis damage in mice by inhibiting apoptosis and activating androgen receptor.
Yuan S, Guo J, Yang B, Huang AX, Hu S, Li Y, Chen J, Yuan B, Yang J
Biochemical and biophysical research communications 2025 May 20;759:151642
Biochemical and biophysical research communications 2025 May 20;759:151642
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Zhang HJ, Zhao Q, Zhang M, Yang LL, Abiti J, Han MM, Gao YP, Lu JT, Wang JN, Ji MY, Zhang X, Wang W, Qiu LL, Wang XY, Wang TY, Jia YL
ACS synthetic biology 2025 May 16;14(5):1802-1812
ACS synthetic biology 2025 May 16;14(5):1802-1812
Microneedle-mediated hypoxic extracellular vesicle-encapsulated selenium nanoparticles delivery to treat androgenetic alopecia.
Jing S, Liu Y, Wang B, Zhou H, Zhang H, Siwakoti P, Qu X, Ye P, He Y, Kumeria T, Ye Q
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113597
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113597
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
Li Q, Zhang C, Qi E, Wu M, Sun H, Zhang T, Jiang Y, Li H, Jiang R, Li C, Zhao H, Zhou H, Feng S
Journal of orthopaedic translation 2025 Mar;51:119-131
Journal of orthopaedic translation 2025 Mar;51:119-131
Knockdown of HOTAIR Alleviates High Glucose-Induced Apoptosis and Inflammation in Retinal Pigment Epithelial Cells.
Wu Y, Liang Z, Li K, Feng J
Applied biochemistry and biotechnology 2025 Mar;197(3):1743-1759
Applied biochemistry and biotechnology 2025 Mar;197(3):1743-1759
SGK1 mediates herpes simplex keratitis via the PI3K/SGK1/ Wnt signaling pathways.
Ye W, Tang S, Wang Y, Wang W, Liu Y, Xu H, Meng H, Lu Y, Huang Z, Ge Y
Cellular signalling 2025 Mar;127:111566
Cellular signalling 2025 Mar;127:111566
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Yang J, Duan C, Wang P, Zhang S, Gao Y, Lu S, Ji Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis.
Cao G, Li C, Zhang J, Deng L, Li R, Xu C
Cryobiology 2025 Mar;118:105196
Cryobiology 2025 Mar;118:105196
Piezo1 promotes intervertebral disc degeneration through the Ca(2+)/F-actin/Yap signaling axis.
Peng F, Sun M, Jing X, Chen F, Cao T, Li Z, Li T
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Molecular medicine (Cambridge, Mass.) 2025 Mar 8;31(1):90
Tremella polysaccharide microneedles loaded with magnetic dental pulp stem cell intracellular vesicles used for androgenic alopecia.
Liu Y, Zhou H, Pang P, Liu Y, Situ J, Wang J, He Y, Ye Q
Stem cell research & therapy 2025 Mar 31;16(1):161
Stem cell research & therapy 2025 Mar 31;16(1):161
Exploring the effect of chlorogenic acid on oxidative stress and autophagy in dry eye mice via the AMPK/ULK1 pathway.
Chen H, Shi J, Tang Y, Chen X, Wang Z, Liu Q, Wu K, Yao X
European journal of pharmacology 2025 Mar 15;991:177311
European journal of pharmacology 2025 Mar 15;991:177311
CHCHD2 rescues the mitochondrial dysfunction in iPSC-derived neurons from patient with Mohr-Tranebjaerg syndrome.
Huang Y, Chen Z, Deng W, Jiang Y, Pan Y, Yuan Z, Hu H, Wu Y, Hu Y
Cell death & disease 2025 Mar 12;16(1):173
Cell death & disease 2025 Mar 12;16(1):173
Blocking GATA6 Alleviates Pyroptosis and Inhibits Abdominal Wall Endometriosis Lesion Growth Through Inactivating the PI3K/AKT Pathway.
Du X, Yang H, Kang X, Fu C, Yang T
Cell biochemistry and biophysics 2025 Jun;83(2):1757-1770
Cell biochemistry and biophysics 2025 Jun;83(2):1757-1770
Application of (68)Ga- and (177)Lu-Labeled FAP Inhibitor in Evaluation and Treatment of Cardiac Fibrosis After Myocardial Infarction.
Zhao Y, Su X, Xiang B, Zhang S, Zhou X
MedComm 2025 Jun;6(6):e70198
MedComm 2025 Jun;6(6):e70198
Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Through the Promotion of Type 2 Macrophage Polarization.
Zhu X, Wang Y, Sun Z, Cheng W, Chen K, Gao X, Meng J, Li S, Zheng W, Wang Y, Yin X, Zhou X
Stem cells and development 2025 Jun;34(11-12):258-270
Stem cells and development 2025 Jun;34(11-12):258-270
miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition.
Hong Y, Feng Z, Ge Y, Xi Y, Zhang B, Wu J, Xia T, Tang B, Wang W, Chen J, Wang H, Xiao H
Regenerative therapy 2025 Jun;29:455-465
Regenerative therapy 2025 Jun;29:455-465
Paeonol enhances a recombinant EGFR-targeted fusion protein-drug conjugate induced antitumor efficacy in esophageal cancer.
Duan H, Li Y, Zheng X, Hou J, Tao H, Liu X, Dai M, He S
Biochemical pharmacology 2025 Jun;236:116856
Biochemical pharmacology 2025 Jun;236:116856
Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis.
Cao Y, Hu L, Chen R, Chen Y, Liu H, Wei J
Cellular signalling 2025 Jun;130:111702
Cellular signalling 2025 Jun;130:111702
Can linc00968 Regulate SH-SY5Y Cell Apoptosis Induced by Amyloid beta Neurotoxicity?
Kurt S, Karagur ER, Kavak DE, Kizildag S
Molecular biology reports 2025 Jun 6;52(1):557
Molecular biology reports 2025 Jun 6;52(1):557
Txnip/Trx Is a Potential Element in Regulating O-GlcNAc Modification in Photoreceptors to Alleviate Diabetic Retinopathy.
Imdad L, Xu S, Meng Y, Bao K, Dong W, Yin X, Tong Y, Zhang W, Ren X, Kong L
International journal of molecular sciences 2025 Jun 4;26(11)
International journal of molecular sciences 2025 Jun 4;26(11)
L1CAM mimetic compound duloxetine improves cognitive impairment in 5xFAD mice and protects Aβ1-42-damaged HT22 cells.
Chen H, Fang Z, Lin SL, Schachner M
European journal of pharmacology 2025 Jun 15;997:177476
European journal of pharmacology 2025 Jun 15;997:177476
Long Noncoding RNA NONHSAT233728.1 Promotes ROS Accumulation and Granulosa Cell Apoptosis by Regulating the MAPK/ERK1/2 Signaling Pathway.
Chen Y, Dai H, Mao F, Li Y, Feng R, Qian Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70681
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70681
Podophyllum hexandrum Royle mitigates perimenopausal symptoms in an OVX rat model by activating the PI3K/AKT/mTOR pathway and enhancing estrogen receptor expression.
Tan CC, Cao SJ, Chao WH, Zhang B, Deng XY, Wang LN, Kang N, Qiu F
Journal of ethnopharmacology 2025 Jun 12;349:119968
Journal of ethnopharmacology 2025 Jun 12;349:119968
Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2.
Luo S, Yang M, Jiang N, Li C, Liu Y, Sun L
Molecular medicine (Cambridge, Mass.) 2025 Jun 11;31(1):234
Molecular medicine (Cambridge, Mass.) 2025 Jun 11;31(1):234
Isomeric 2-isobutylmalate derivatives with anti-pulmonary fibrosis effects from the leaves of Bletilla striata via LC-MS/MS-based molecular networking.
Zhou M, Liu S, Yuan F, Li J, Zhou M, Huang J, Zhang Y, Liang Q
Bioorganic chemistry 2025 Jun 1;159:108351
Bioorganic chemistry 2025 Jun 1;159:108351
TREM2 Modulates Postoperative Cognitive Function in Aged Mice by Inhibiting the NLRP3/caspase-1 Pathway and Apoptosis via PLCγ2 Activation.
Zhang X, Wang R, Pan X, Chen Z, Li Y, Hu Y, Liu F, Cao X
Molecular neurobiology 2025 Jul;62(7):8986-8999
Molecular neurobiology 2025 Jul;62(7):8986-8999
The novel piperine derivative MHJ-LN inhibits breast cancer by inducing apoptosis via p53 activation.
Ren H, Gao Q, Wang M, Zhang L, Wang S, Zhang X, Li H, Ye X, Zhou L, Zhou C, Li X, Zeng K, Ji J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jul;398(7):9031-9042
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jul;398(7):9031-9042
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316
Cell death and differentiation 2025 Jul;32(7):1303-1316
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
Zhang X, Tang X, Gao T, Guo Y, Lu G, Liu Q, Li J, Wang J, Liu M, Zhang D, Tang Y, Gu J
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3591-3610
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3591-3610
Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD-MCI mice.
Tuersong T, Wu QF, Chen Y, Shan Li P, Yong YX, Shataer M, Shataer S, Ma LY, Yang XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156729
2-Hydroxy-3-Methylanthraquinone Suppresses Hepatocellular Carcinoma Progression by Blocking Annexin A5-Mediated Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling.
Luo M, Mo J, Huang C, Mao Y, Wang H, Wang X
Chemical biology & drug design 2025 Jul;106(1):e70161
Chemical biology & drug design 2025 Jul;106(1):e70161
Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis.
Yan X, Lin X, Wu J, Zheng L, Liu Y, Wu F, Lin Y, Lu Y, Huang C, Shen B, Liu H, Huang R, Hou F, Zhou Q, Song M, Liu K, Zhu F, Li S, Lin Y, Wang W, Li P, Liao W, Zhi F
BMC medicine 2025 Jul 7;23(1):408
BMC medicine 2025 Jul 7;23(1):408
Soy Isoflavone Supplementation in Sow Diet Enhances Antioxidant Status and Promotes Intestinal Health of Newborn Piglets.
Liu L, Niu L, Xu M, Yu Q, Chen L, Deng H, Chen W, Che L
Animals : an open access journal from MDPI 2025 Jul 28;15(15)
Animals : an open access journal from MDPI 2025 Jul 28;15(15)
Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.
Zhao B, Liu R, Guo S, Li S, Huang Z, Wang Y, Yu C, Hou Z, Zhang Y, Zhang Y, Liu X
Scientific reports 2025 Jul 22;15(1):26616
Scientific reports 2025 Jul 22;15(1):26616
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest.
Lee KT, Lieu AS, Lin CL, Hsu YC, Tsai TH
Medical oncology (Northwood, London, England) 2025 Jul 20;42(8):353
Medical oncology (Northwood, London, England) 2025 Jul 20;42(8):353
Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway.
Wang Y, Yang W, Zuo H, Zeng S, Liu X, Cao F, Yang H, Gao S, Tian M, Gao X, Xiang Y, Huang F, Chu B, Wu C, Feng H, Wan W, Zheng S, Hou S, Hu K
iScience 2025 Jul 18;28(7):112796
iScience 2025 Jul 18;28(7):112796
Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells.
Lee SH, Lee SJ, Koh A, Kim KH, Kim KW
Investigative ophthalmology & visual science 2025 Jul 1;66(9):49
Investigative ophthalmology & visual science 2025 Jul 1;66(9):49
METTL3 methylated KIF15 promotes nasopharyngeal carcinoma progression and radiation resistance by blocking ATG7-mediated autophagy through the activation of STAT3 pathway.
Li S, Wang S, Zhang L, Wu X, Tian L, Zou J, Pi G
Translational oncology 2025 Jan;51:102161
Translational oncology 2025 Jan;51:102161
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity.
Guo X, Liang XJ, Liu JL, Li ZH, You Z, Zhao D, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Jan 9;68(1):387-404
Journal of medicinal chemistry 2025 Jan 9;68(1):387-404
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway.
Wang D, Zhao X, Li J, Song Y, Chen W, Cai X, Liu R, Chen Z
Metabolic brain disease 2025 Jan 7;40(1):91
Metabolic brain disease 2025 Jan 7;40(1):91
Formin protein DAAM1 positively regulates PD-L1 expression via mediating the JAK1/STAT1 axis in pancreatic cancer.
Xu R, Wan M, Pan J, Mei J, Zhou J, Shen Y, Yang J, Zhu Y, Sun J
Cancer cell international 2025 Jan 29;25(1):28
Cancer cell international 2025 Jan 29;25(1):28
A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer.
Zheng X, Wang Y, Duan H, Hou J, He S
Journal of nanobiotechnology 2025 Jan 28;23(1):52
Journal of nanobiotechnology 2025 Jan 28;23(1):52
Discovery of HZS60 as a Novel Brain Penetrant NMDAR/TRPM4 Interaction Interface Inhibitor with Improved Activity and Pharmacokinetic Properties for the Treatment of Cerebral Ischemia.
Sun M, Wang L, Cao Q, Wang X, Zhang Y, Guo M, Chen J, Ma Y, Niu L, Zhang Y, Hu M, Gu M, Zhu Z, Yao X, Yao J, Zhao C, Wu J, Liu X, Lu Y, Wang Z, Xiang Q, Han F, Zhu D
Journal of medicinal chemistry 2025 Jan 23;68(2):2008-2043
Journal of medicinal chemistry 2025 Jan 23;68(2):2008-2043
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy.
Pan Y, Li Y, Zhou X, Luo J, Ding Q, Pan R, Tian X
ACS applied materials & interfaces 2025 Jan 22;17(3):4608-4625
ACS applied materials & interfaces 2025 Jan 22;17(3):4608-4625
Citrinin-Induced Cellular Damage: Insights from SH-SY5Y Cell Line Studies.
Martí-Quijal FJ, Franco-Campos F, Barba FJ, Ruiz MJ
Foods (Basel, Switzerland) 2025 Jan 22;14(3)
Foods (Basel, Switzerland) 2025 Jan 22;14(3)
Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss.
Liu J, Peng H, Liu Y, Li C, Xie W
Frontiers in bioscience (Landmark edition) 2025 Jan 15;30(1):26179
Frontiers in bioscience (Landmark edition) 2025 Jan 15;30(1):26179
Self-Assembled Pt/Honokiol Nanomicelles for the Treatment of Sepsis-Associated Acute Kidney Injury.
Liu C, Cao Z, Li L, Li Q, Zhang C, Wang Y, Li L, Fu P
ACS biomaterials science & engineering 2025 Jan 13;11(1):383-401
ACS biomaterials science & engineering 2025 Jan 13;11(1):383-401
ACSL5 promotes lipid deposition and lipoapoptosis in proximal tubular epithelial cells of diabetic kidney disease.
Xi Y, Yang M, Deng Z, Xiong X, Wei L, Cai J, Tang C, Sun L
Molecular and cellular endocrinology 2025 Jan 1;595:112418
Molecular and cellular endocrinology 2025 Jan 1;595:112418
MiR-146a-5p downregulated TRAF6/NF-κB p65 pathway to attenuate the injury of HT-22 cells induced by oxygen-glucose deprivation/reoxygenation.
Deng Y, Wang G, Hou D, Zhang L, Pei C, Yang G
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):178-188
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):178-188
Methamphetamine inhibits huntingtin-associated protein 1-mediated tyrosine receptor kinase B endocytosis resulting the neuroprotective dysfunction of brain-derived neurotrophic factor.
Shen B, Wu Z, Lv M, Yang G, Cao Y, Zhang Y, Shu J, Dong W, Hou Z, Jing D, Zhang X, Hou Y, Xu J, Hong S, Li L
Toxicology 2025 Feb;511:154047
Toxicology 2025 Feb;511:154047
Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction.
Wang P, Ouyang J, Zhou K, Hu D, Zhang S, Zhang A, Yang Y
Biomedical journal 2025 Feb;48(1):100730
Biomedical journal 2025 Feb;48(1):100730
Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy.
Yang N, Sun S, Xu J, Gong F, Lei H, Hao Y, Pei Z, Wang C, Yu Q, Nie J, Jiang N, Ni C, Cheng L
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(8):e2414929
Advanced materials (Deerfield Beach, Fla.) 2025 Feb;37(8):e2414929
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis.
Gu B, Yu W, Huang Z, Bai J, Liu S, Ren B, Wang P, Sun L, Wen J, Zheng Y, Tan P, Fu W
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):149-166
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):149-166
Role of calcium overload-mediated disruption of mitochondrial dynamics in offspring neurotoxicity due to methylmercury exposure during pregnancy and lactation.
Kong L, Yang H, Yang J, Jiang L, Xu B, Yang T, Liu W
Ecotoxicology and environmental safety 2025 Feb;291:117835
Ecotoxicology and environmental safety 2025 Feb;291:117835
A quercetin nanoparticle combined with a 3D-printed decellularized extracellular matrix/ gelatin methacryloyl/sodium alginate biomimetic tumor model for the treatment of melanoma.
Fang H, Xu J, Ma H, Feng Z, Cheng YY, Nie Y, Guan Y, Liu Y, Song K
International journal of biological macromolecules 2025 Feb;288:138680
International journal of biological macromolecules 2025 Feb;288:138680
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
Wang L, Sang W, Jian Y, Han Y, Wang F, Wubulikasimu S, Yang L, Tang B, Li Y
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse.
Cheng SY, Yang YF, Wang YL, Yue ZP, Chen YZ, Wang WK, Xu ZR, Li LF, Shen H, Qi ZM, Xu CL, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Feb;196:115201
METRNL exerts cytoprotective effects on EPCs via regulation of the E2F1-TXNIP axis in obese limb ischemia.
Li J, Ge Z, Li C, Ran H, Zhang Y, Xiang Y
Cellular signalling 2025 Feb;126:111528
Cellular signalling 2025 Feb;126:111528
Lactobacillus gasseri prevents ibrutinib-associated atrial fibrillation through butyrate.
Shi L, Duan Y, Fang N, Zhang N, Yan S, Wang K, Hou T, Wang Z, Jiang X, Gao Q, Zhang S, Li Y, Zhang Y, Gong Y
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Feb 5;27(2)
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 Feb 5;27(2)
The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy.
Wen E, Tian Y, Fang M, Zhang Y, Zhao H, Wang Z, Zhang L, Li X
ACS applied materials & interfaces 2025 Feb 5;17(5):7521-7538
ACS applied materials & interfaces 2025 Feb 5;17(5):7521-7538
Iron overload mediates cytarabine resistance in AML by inhibiting the TP53 signaling pathway.
Jia Y, Li L, Li Y, Zhu X, Wang H, Xu B, Li Q, Zhang H
Acta biochimica et biophysica Sinica 2025 Feb 28;57(4):646-655
Acta biochimica et biophysica Sinica 2025 Feb 28;57(4):646-655
Dan-Shen-Yin against alcohol-induced gastric injury in rats by inhibiting apoptosis via IP3R-controlled calcium release.
Zhou Z, Dong J, Lei P, Zhang Q, Jiang M
Journal of ethnopharmacology 2025 Feb 27;342:119413
Journal of ethnopharmacology 2025 Feb 27;342:119413
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
The effects of metformin on inflammation and apoptosis in rats with preeclampsia.
Chen Y, Gao Z, Wang L, Duan R, Hao H, Jia R, Ma H, Gao R, Su M, Yang H, Tu Z
Journal of hypertension 2025 Feb 1;43(2):255-263
Journal of hypertension 2025 Feb 1;43(2):255-263
CircRNA circACTN4 Promotes the Progression of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the miR-424-5p/NCAPG/Wnt Axis.
Shan J, Pu J, Chen X, Zhang Y, Li J, Qin L, Shi J, Zhou L, Deng Y
Clinical and experimental medicine 2025 Feb 1;25(1):47
Clinical and experimental medicine 2025 Feb 1;25(1):47
Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells.
Liang W, Chen X, Ni N, Zhuang C, Yu Z, Xu Z, Li Y, Lin C, Huang K
Annals of medicine 2025 Dec;57(1):2490823
Annals of medicine 2025 Dec;57(1):2490823
Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis: Modulating Crotonylation in Ulcerative Colitis.
Liu T, Lin B, Zhang Y, Su J, Hu X, Wang X, Liu EH, Liu S
Exploration (Beijing, China) 2025 Dec;5(6):20240129
Exploration (Beijing, China) 2025 Dec;5(6):20240129
SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1.
Zhang Y, He F, Cai N, Chen G, Wang Y, Bai W, Guo P
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2515516
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2515516
DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.
Zhang H, Zhang N, Yang X, Zhang J, Ge X, Wang L, Wang S, Wen Y
CNS neuroscience & therapeutics 2025 Dec;31(12):e70682
CNS neuroscience & therapeutics 2025 Dec;31(12):e70682
A Novel COL12A1 Mutation Causes Oral Tissue Abnormalities by Regulating Gingival Fibroblast Function.
Yu S, Wang Y, Yuan X, Yang Y, Wang X, Qin M
Oral diseases 2025 Dec;31(12):3450-3460
Oral diseases 2025 Dec;31(12):3450-3460
COX-2 targeting Ru-arene complexes from metal-ligand synergistic enhancement strategy for breast cancer therapy.
Zhang GD, Hao W, Yu ZH, Liu HK, Su Z
Journal of inorganic biochemistry 2025 Dec;273:113044
Journal of inorganic biochemistry 2025 Dec;273:113044
Arsenic-induced circFNDC3B regulates apoptosis through dysregulation of NF-κB Signaling.
Jiang J, Ma H, Liu N, Li S, Ma Q, Li S, He Y, Jiang C
Toxicology research 2025 Dec;14(6):tfaf152
Toxicology research 2025 Dec;14(6):tfaf152
Deficiency of SCAMP5 Triggers Pancreatic β-Cell Secretory Dysfunction and Apoptosis.
Zhang Y, Tang D, Yang C, Lin C, Yuan Y, He M, Chen Y, Mao Z, Ying Y, Ma X, Kong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e03072
A machine learning-based glycolysis and fatty acid metabolism-related prognostic signature is constructed and identified ACSL5 as a novel marker inhibiting the proliferation of breast cancer.
Liang MZ, Huang XF, Zhu JC, Bao JX, Chen CL, Wang XW, Lou YW, Pan YT, Dai YW
Computational biology and chemistry 2025 Dec;119:108507
Computational biology and chemistry 2025 Dec;119:108507
Aloperine exerts anti-tumor effect and activates the tumor cell-intrinsic STING pathway in gallbladder cancer.
Chang Y, Lin J, Yang B, Shen Y, Zhao W, Shen H, Yang Q, Lu H, Cai X, Wang Y, Hua W
International immunopharmacology 2025 Dec 3;166:115590
International immunopharmacology 2025 Dec 3;166:115590
An Enhanced Cancer Immunogenic Cell Death Strategy: Fibrate-Oxaliplatin(IV) Conjugates with Modulating Tumor Immune Microenvironment.
Liang XJ, Guo X, Zhu PH, Zhao ZH, You Z, Yang K, Song Y, Li L, Song XQ
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347
Journal of medicinal chemistry 2025 Dec 25;68(24):26328-26347
Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer.
Wang L, Zheng L, Yong X, Ding Z, Sun J, Tang Y, Tang K, Li Y, Chen J, Qi S, Hu H, Tang H
Journal of translational medicine 2025 Dec 22;24(1):70
Journal of translational medicine 2025 Dec 22;24(1):70
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
Han L, Zhai H, Ma X, Li H, Ren Q, Liu J, Zhang Z, Li X, Zhang Q, Sun X
Current issues in molecular biology 2025 Dec 20;48(1)
Current issues in molecular biology 2025 Dec 20;48(1)
Identification and biological evaluation of novel indole-2-one derivatives as BRD4-BD2 inhibitors.
Yang CJ, Cui QH, Lyu HJ, Wang ZY, Wang QS, Xiang R, Chen SW
Bioorganic & medicinal chemistry 2025 Dec 1;130:118379
Bioorganic & medicinal chemistry 2025 Dec 1;130:118379
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis.
Wang Z, Yang Y, Yao FT, Zhang F, Lin KY, Diao HT, Zhao QY, Kong X, Si W, Xie YT, Song JL, Zeng LH, Wang CL, Xiong YT, Zou KK, Wang XM, Zhang XY, Wu H, Jiang WT, Bian Y, Yang BF
Acta pharmacologica Sinica 2025 Aug;46(8):2282-2295
Acta pharmacologica Sinica 2025 Aug;46(8):2282-2295
Icariin attenuates oxidative stress via SIRT1/PGC-1α pathway in SAH mice.
Lei X, Wen D, Huang Z, Li X, Liuyang Tang, Zhu Y, Guo Z
Experimental neurology 2025 Aug;390:115303
Experimental neurology 2025 Aug;390:115303
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
Yang S, Sun Y, Luo W, Zhou X, Gu X, Zhang W, Zhu H, Wu W, Wu X, Yu M, Wang S
Materials today. Bio 2025 Aug;33:101930
Materials today. Bio 2025 Aug;33:101930
Crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress in apoptosis: Implications for grass carp flesh quality during cold storage.
Xiong X, Li Q, Chen L, Zhuang S, Tan Y, Hong H, Luo Y
Food chemistry 2025 Aug 30;484:144425
Food chemistry 2025 Aug 30;484:144425
Neuroprotective effects of Yangming-Kaixin-Yizhi formula in Alzheimer's disease: dual regulation of PI3K/Akt and p38 MAPK signaling via network pharmacology and experimental approaches.
Lei J, Li J, Wu W, Xiong R, Liu Y, Tang Y
Metabolic brain disease 2025 Aug 29;40(7):254
Metabolic brain disease 2025 Aug 29;40(7):254
Pyrazolamide derivative T1 inhibits hepatocellular carcinoma cell proliferation through MAPK pathway modulation.
Zhang Y, Chen Y, Lv H, Wang H, Wang J, Lv X, Zhang M
International immunopharmacology 2025 Aug 28;161:115044
International immunopharmacology 2025 Aug 28;161:115044
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
Li N, Liu X, Wang Q, Chen Y, Han C, Qu C, Guan X, Zou W, Wang X, Li A, Zhang Y, Zhu L, Du R, Liu J, Wang Y
Stem cell research & therapy 2025 Aug 2;16(1):419
Stem cell research & therapy 2025 Aug 2;16(1):419
Mechanisms of Differential Sensitivity to Ethanol-Induced Apoptosis in Mouse Spinal Cord at Different Developmental Stages-Akt/GSK Signaling and BAX.
Sun S, Wang Z, Xu X, Ding X, Xu J, Nan X, Li X, Xu J, Ren Z
Molecular neurobiology 2025 Apr;62(4):4301-4318
Molecular neurobiology 2025 Apr;62(4):4301-4318
Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.
Li J, Wu X, Yan S, Shen J, Tong T, Aslam MS, Zeng J, Chen Y, Chen W, Li M, You Z, Gong K, Yang J, Zhu M, Meng X
Molecular neurobiology 2025 Apr;62(4):4221-4236
Molecular neurobiology 2025 Apr;62(4):4221-4236
Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1/p53 and PI3K/AKT signaling pathways.
Liu XL, Zu S, Yue H, Li AN, Sun PP, Li JG, Yan L, Ma LN, Zhang S
Journal of Asian natural products research 2025 Apr;27(4):615-631
Journal of Asian natural products research 2025 Apr;27(4):615-631
Pharmacological Inhibition of TXNRD1 by a Small Molecule Flavonoid Butein Overcomes Cisplatin Resistance in Lung Cancer Cells.
Yang R, Sun S, Zhang Q, Liu H, Wang L, Meng Y, Chen N, Wang Z, Liu H, Ji F, Dai Y, He G, Xu W, Ye Z, Zhang J, Ma Q, Xu J
Biological trace element research 2025 Apr;203(4):1949-1960
Biological trace element research 2025 Apr;203(4):1949-1960
Inhibition of MALAT1 facilitates ROS accumulation via the Keap1/HO-1 pathway to enhance photodynamic therapy in secondary hyperparathyroidism.
Wen Y, Li Y, Zhang D, Liu Z, Liu H, Li X, Wu W, Zeng L, Zou Q, Yi W
Non-coding RNA research 2025 Apr;11:249-261
Non-coding RNA research 2025 Apr;11:249-261
Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload.
Zhang Y, Wu Q, Bai F, Hu Y, Xu B, Tang Y, Wu J
Journal of ovarian research 2025 Apr 9;18(1):75
Journal of ovarian research 2025 Apr 9;18(1):75
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.
Liu S, Zhuang S, Li R, Duan H
Diabetology & metabolic syndrome 2025 Apr 9;17(1):122
Diabetology & metabolic syndrome 2025 Apr 9;17(1):122
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
He X, Tian S, Bu L, Zhao X, Zheng L, Zhang P, Guo R, Ma M
Scientific reports 2025 Apr 3;15(1):11502
Scientific reports 2025 Apr 3;15(1):11502
Exploring the Molecular Mechanism of 1,25(OH)(2)D(3) Reversal of Sorafenib Resistance in Hepatocellular Carcinoma Based on Network Pharmacology and Experimental Validation.
Long Z, Wu X, Luo T, Chen X, Huang J, Zhang S
Current issues in molecular biology 2025 Apr 29;47(5)
Current issues in molecular biology 2025 Apr 29;47(5)
The African swine fever virus MGF360-16R protein functions as a mitochondrial-dependent apoptosis inducer by competing with BAX to bind to the HSP60 protein.
Xiang Z, Xu Z, Weng W, Wang H, Wu J, Jiang F, Qu Y, Li Q, Gao P, Zhou L, Ge X, Guo X, Han J, Zhang Y, Yang H
Journal of virology 2025 Apr 15;99(4):e0140124
Journal of virology 2025 Apr 15;99(4):e0140124
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
Benedetti R, Di Crosta M, Gilardini Montani MS, D'Orazi G, Cirone M
Cell death discovery 2025 Apr 10;11(1):162
Cell death discovery 2025 Apr 10;11(1):162
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury.
Xiao Y, He Y, Zhong D, Liu B, Tang Z, Lan X, Dong Y, Du H, Liu Y, Luo J
ACS nano 2025 Apr 1;19(12):11841-11860
ACS nano 2025 Apr 1;19(12):11841-11860
Molecular Mechanism of Caulis Spatholobi in the Treatment of Chronic Myeloid Leukemia based on Network Pharmacology and Experimental Verification.
Wu Y, Lian F, Chen H, Zhang C, Wei L, Tian H
Current computer-aided drug design 2024;20(1):49-59
Current computer-aided drug design 2024;20(1):49-59
Polydopamine-Based Nanoparticles for Synergistic Chemotherapy of Prostate Cancer.
Hu K, Zhang D, Ma W, Gu Y, Zhao J, Mu X
International journal of nanomedicine 2024;19:6717-6730
International journal of nanomedicine 2024;19:6717-6730
Rebaudioside B Attenuates Lung Ischemia-reperfusion Injury Associated Apoptosis and Inflammation.
Wu X, Qiao T, Huang J, Li J, Wei S, Yang J, Zhang Y, Li Y
Recent advances in inflammation & allergy drug discovery 2024;18(2):156-166
Recent advances in inflammation & allergy drug discovery 2024;18(2):156-166
Cross-border regulation of the STK39/MAPK14 pathway by Lycium barbarum miR166a to inhibit triple-negative breast cancer.
Hou Y, Li J, Li X, Lv Y, Yuan C, Tian J, Liu X
American journal of translational research 2024;16(6):2683-2698
American journal of translational research 2024;16(6):2683-2698
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells.
Tao Y, Niu Q, Yao Y, Wang K, Dong H, Zhao X, Zeng Z, Li H
Frontiers in pharmacology 2024;15:1528100
Frontiers in pharmacology 2024;15:1528100
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Qin Y, Gao Y, Wu D, Liu QQ, Su C, Liu G, Yang L, Zhao MG, Yao JY
Frontiers in pharmacology 2024;15:1509482
Frontiers in pharmacology 2024;15:1509482
Qingre Huoxue decoction attenuates myocardial ischemia‒reperfusion injury by regulating the autophagy‒endoplasmic reticulum stress axis via FAM134B-mediated ER-phagy.
Li R, Zhang J, Ji S, Fang J, Ji X, Zeng Y, Liu N, Wu W, Liu S
Frontiers in pharmacology 2024;15:1447610
Frontiers in pharmacology 2024;15:1447610
Baitouweng decoction alleviates ulcerative colitis by regulating tryptophan metabolism through DOPA decarboxylase promotion.
Zhang J, Lin B, Zhang Y, Hu X, Liu T, Liu EH, Liu S
Frontiers in pharmacology 2024;15:1423307
Frontiers in pharmacology 2024;15:1423307
Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy.
Wang J, Zhang M, You X, Xu Y, Zhang C, Li Y, Yang C, Wang Q
Frontiers in pharmacology 2024;15:1415310
Frontiers in pharmacology 2024;15:1415310
B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosis.
Varier KM, Dan G, Li X, Liu W, Jiang F, Linghu KG, Li Y, Ben-David Y, Zhang N, Xiao C, Gajendran B, Shen X
Frontiers in pharmacology 2024;15:1408389
Frontiers in pharmacology 2024;15:1408389
Induction of apoptosis by oridonin in nonfunctioning pituitary adenoma cells.
Chen HT, Yuan XY, Wang ZY, Fan D, Luo XM, Yang JH, Ma YX, Liu J, Wang X, Wang ZM
Drug development research 2024 Sep;85(6):e22251
Drug development research 2024 Sep;85(6):e22251
Increased expression of SLC25A18 is associated with Alzheimer's disease and is involved in Aβ42-induced mitochondrial dysfunction and apoptosis in neuronal cells.
Song JY, Jia Y, Han H, Yang XH, Zhang J, Zhang Q, Wang SS, Wang CY, Chen L, Zhang M
Mitochondrion 2024 Sep;78:101918
Mitochondrion 2024 Sep;78:101918
Esculentoside H reduces the PANoptosis and protects the blood-brain barrier after cerebral ischemia/reperfusion through the TLE1/PI3K/AKT signaling pathway.
Zhang K, Wang ZC, Sun H, Long H, Wang Y
Experimental neurology 2024 Sep;379:114850
Experimental neurology 2024 Sep;379:114850
Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor.
Liu X, Cheng LT, Ye QR, Gao HC, Zhu JW, Zhao K, Liu HM, Wang YJ, Alinejad T, Zhang XH, Chen GZ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117172
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117172
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.
Xiao MY, Pei WJ, Li S, Li FF, Xie P, Luo HT, Hyun Yoo H, Piao XL
Bioorganic chemistry 2024 Sep;150:107539
Bioorganic chemistry 2024 Sep;150:107539
Catecholamines-based myocardial injury after acute ischemic stroke and effects of Naoxintong capsule therapy.
Ouyang Y, Hu S, Chang M, Xu J, Tian G, Kong X, Liu J, Zhang D, Zhang F, Yang H, Tang L, Wu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155697
Exercise-promoted adiponectin secretion activates autolysosomes to protect the liver of ApoE(-/-) mice from a high-fat diet.
Wu W, Jian Y, Yuan S, Li X, Tang Y, Zeng F, Liu W, Zhao Z, Wang Y, Wang Y, Liu W
Food & function 2024 Sep 30;15(19):9796-9812
Food & function 2024 Sep 30;15(19):9796-9812
Omaveloxolone ameliorates glucocorticoid-induced osteonecrosis of the femoral head by promoting osteogenesis and angiogenesis.
Wan C, Liang C, Peng H
Biochemical and biophysical research communications 2024 Sep 3;723:150188
Biochemical and biophysical research communications 2024 Sep 3;723:150188
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Niu Q, Li D, Guo W, Feng Z, Han Z, Yang Y
BMC endocrine disorders 2024 Sep 10;24(1):184
BMC endocrine disorders 2024 Sep 10;24(1):184
Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.
Wang Y, Chen SJ, Ma T, Long Q, Chen L, Xu KX, Cao Y
International immunopharmacology 2024 Sep 10;138:112517
International immunopharmacology 2024 Sep 10;138:112517
Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice.
Chen F, Zhang M, Song Z, Meng R, He J, Xu X, Deng S, Sun M, Kou Z, Lin J
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C778-C789
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C778-C789
Design, synthesis, and biological evaluation of naphthalene imidazo[1,2-b]pyridazine hybrid derivatives as VEGFR selective inhibitors.
Wang S, Gan L, Han L, Deng P, Li Y, He D, Chi H, Zhu L, Li Y, Long R, Gan Z
Archiv der Pharmazie 2024 Oct;357(10):e2400411
Archiv der Pharmazie 2024 Oct;357(10):e2400411
The resistance to anoikis, mediated by Spp1, and the evasion of immune surveillance facilitate the invasion and metastasis of hepatocellular carcinoma.
Zhang Z, Chen X, Li Y, Zhang F, Quan Z, Wang Z, Yang Y, Si W, Xiong Y, Ju J, Bian Y, Sun S
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1564-1583
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1564-1583
Emodin combined with 5-aminolevulinic acid photodynamic therapy inhibits condyloma acuminate angiogenesis by targeting SerRS.
Lu H, Peng Z, Luo Y, Zheng Z, Li C, Wang Q, Han C, Wang Y, Liang L, Zeng K, Chen Y
Journal of cellular and molecular medicine 2024 Oct;28(19):e70122
Journal of cellular and molecular medicine 2024 Oct;28(19):e70122
Prebiotic stachyose inhibits PRDX5 activity and castration-resistant prostate cancer development.
Wang R, Pan Y, Zhang L, Wang J, Ni J, Ding Y, Wang S, Yin J, Ding L, Ran X, Fan S, Sun Q, Tan SY, Koeffler HP, Li J, Mi Y, Chen YQ
International journal of biological macromolecules 2024 Oct;278(Pt 3):134844
International journal of biological macromolecules 2024 Oct;278(Pt 3):134844
Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
Zhang Z, Zheng Y, Zhang B, Wang R, Chen L, Wang Y, Feng W, Zheng X, Li K, Zhou N
Journal of ethnopharmacology 2024 Oct 5;332:118376
Journal of ethnopharmacology 2024 Oct 5;332:118376
Identification and biological evaluation of fused tetrahydroisoquinoline derivatives as Wnt/β-catenin signaling inhibitors to suppress colorectal cancer.
Zhou J, Xu B, Shen Q, Zhang Z, Hu Y, Wang M, Su Y, Lei Z, Zhang W, Liu T, Liu H, Hu T, Zhou Y
European journal of medicinal chemistry 2024 Oct 5;276:116664
European journal of medicinal chemistry 2024 Oct 5;276:116664
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early liver graft injury.
Yang X, Chen H, Shen W, Chen Y, Lin Z, Zhuo J, Wang S, Yang M, Li H, He C, Zhang X, Hu Z, Lian Z, Yang M, Wang R, Li C, Pan B, Xu L, Chen J, Wei X, Wei Q, Xie H, Zheng S, Lu D, Xu X
Nature communications 2024 Oct 3;15(1):8578
Nature communications 2024 Oct 3;15(1):8578
CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy.
Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Chen F, Deng F
Communications biology 2024 Oct 26;7(1):1403
Communications biology 2024 Oct 26;7(1):1403
Peroxiredoxin-5 alleviates early brain injury after subarachnoid hemorrhage by reducing oxidative stress.
Yang J, Wu Q, Lan S, Yuan K, Sun B, Meng Y, Xu S, Shi H
Brain research bulletin 2024 Oct 15;217:111087
Brain research bulletin 2024 Oct 15;217:111087
Protective Effects of Gastrodin Against Gentamicin-Induced Vestibular Damage by the Notch Signaling Pathway.
Jiang W, Li F, Xu H, Cao M, Xiao B, Gong K, Ma J, Zhang W, Tang X, Liu F, Yu S
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2024 Oct 1;45(9):1059-1067
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2024 Oct 1;45(9):1059-1067
FAM83D promotes the progression of 4NQO-induced esophageal carcinoma via inhibiting FBWX7.
Li J, Tian J, Ma M, Qin Z, Cao B, Yang J, Wang X, Yang X
Experimental cell research 2024 Oct 1;442(2):114252
Experimental cell research 2024 Oct 1;442(2):114252
NOD2 reduces the chemoresistance of melanoma by inhibiting the TYMS/PLK1 signaling axis.
Yun F, Wu N, Yi X, Zhang X, Feng Y, Ni Q, Gai Y, Li E, Yang Z, Zhang Q, Sai B, Kuang Y, Zhu Y
Cell death & disease 2024 Oct 1;15(10):720
Cell death & disease 2024 Oct 1;15(10):720
Alcohol promotes hepatocyte injury via ER stress sensor XBP1s mediated regulation of autophagy and lysosomal activity.
Cheng Y, Rao P, Li S, Yu W, Tang Y, Wang R, He W, Liu J
Toxicology and applied pharmacology 2024 Nov;492:117117
Toxicology and applied pharmacology 2024 Nov;492:117117
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
Liu YC, Li RC, Wang WK, Chen YZ, He QK, Xu ZR, Yang YF, Cheng SY, Wang HL, Qi ZQ, Xu CL, Liu Y
Environmental toxicology 2024 Nov;39(11):5074-5085
Environmental toxicology 2024 Nov;39(11):5074-5085
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Shen R, Zhou J, Xin L, Zhou HB, Huang J
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Jin L, Gan D, He W, Wu N, Xiang S, Wei Y, Eriani G, Ji Y, Guan MX, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Hua W, Xie L, Dong C, Yang G, Chi S, Xu Z, Yang C, Wang H, Wu X
Journal of translational medicine 2024 Nov 27;22(1):1071
Journal of translational medicine 2024 Nov 27;22(1):1071
Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm.
Wang H, Xu Z, Guo J, Li L, Tian Y, Fu S
European journal of medical research 2024 Nov 21;29(1):557
European journal of medical research 2024 Nov 21;29(1):557
Mechanism of cold exposure delaying wound healing in mice.
Li FX, Liu JJ, Lei LM, Li YH, Xu F, Lin X, Cui RR, Zheng MH, Guo B, Shan SK, Tang KX, Li CC, Wu YY, Duan JY, Cao YC, Wu YL, He SY, Chen X, Wu F, Yuan LQ
Journal of nanobiotechnology 2024 Nov 20;22(1):723
Journal of nanobiotechnology 2024 Nov 20;22(1):723
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure.
Jin L, Yang Q, Li J, Li X, Xia Y, Chen Z, Wen Y, Wang L, Wang X, Tong J, Shen Y, Chen K
Ecotoxicology and environmental safety 2024 Nov 15;287:117345
Ecotoxicology and environmental safety 2024 Nov 15;287:117345
Pesticide metabolite 3, 5, 6-trichloro-2-pyridinol causes massive damage to the cochlea resulting in hearing loss in adult mice.
Huang M, Mao S, Pan Y, Zhang Z, Gui F, Tan X, Hong Y, Chen R
Environmental pollution (Barking, Essex : 1987) 2024 Nov 1;360:124691
Environmental pollution (Barking, Essex : 1987) 2024 Nov 1;360:124691
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Wang CC, Hu XM, Long YF, Huang HR, He Y, Xu ZR, Qi ZQ
Life sciences 2024 Nov 1;356:123014
Life sciences 2024 Nov 1;356:123014
BL-918 alleviates oxidative stress in rats after subarachnoid hemorrhage by promoting mitophagy through the ULK1/PINK1/Parkin pathway.
Yang J, Wu Q, Li Y, Zhang Y, Lan S, Yuan K, Dai J, Sun B, Meng Y, Xu S, Shi H
Free radical biology & medicine 2024 Nov 1;224:846-861
Free radical biology & medicine 2024 Nov 1;224:846-861
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Liu L, Xiao W, Yang Z, Wang Q, Yi J
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
DNAJA1‑knockout alleviates heat stroke‑induced endothelial barrier disruption via improving thermal tolerance and suppressing the MLCK‑MLC signaling pathway.
Li L, Wang YW, Chang X, Chen JL, Wang M, Zhu JQ, Li JF, Ren LJ, Dai XY, Yan L, Fan XC, Song Q, Zhu JB, Chen JK, Xu SG
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Relationship between circadian rhythm-related genes and extracellular matrix: implications for sleep deprivation.
Liu X, Sun J, Ling Z, Dong T
Sleep & breathing = Schlaf & Atmung 2024 May;28(2):697-705
Sleep & breathing = Schlaf & Atmung 2024 May;28(2):697-705
Rapid discovery of a novel "green" and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy.
Mao L, Qin Y, Fan J, Yang W, Li B, Cao L, Yuan L, Wang M, Liu B, Wang W
Journal of pharmaceutical analysis 2024 May;14(5):100923
Journal of pharmaceutical analysis 2024 May;14(5):100923
A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin-induced hepatotoxicity in mice.
Xiong L, Lin K, He T, Liu X, Yuan R, Li X, Zhang J
Basic & clinical pharmacology & toxicology 2024 May;134(5):737-749
Basic & clinical pharmacology & toxicology 2024 May;134(5):737-749
Tetramethylpyrazine-loaded electroconductive hydrogels promote tissue repair after spinal cord injury by protecting the blood-spinal cord barrier and neurons.
Deng B, Jiang S, Liu G, Li X, Zhao Y, Fan X, Ren J, Ning C, Xu L, Ji L, Mu X
Journal of materials chemistry. B 2024 May 8;12(18):4409-4426
Journal of materials chemistry. B 2024 May 8;12(18):4409-4426
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Liu X, Liu R, Wang Y
Biochemical and biophysical research communications 2024 May 28;710:149880
Biochemical and biophysical research communications 2024 May 28;710:149880
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21.
Guo D, Zhou S, Liu R, Yao W, Li S, Zhang X, Shen W, Zhu S
Cancer cell international 2024 May 23;24(1):179
Cancer cell international 2024 May 23;24(1):179
Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia.
Ye X, Lin ZJ, Hong GH, Wang ZM, Dou RT, Lin JY, Xie JH, Shen YW
Experimental cell research 2024 May 15;438(2):114061
Experimental cell research 2024 May 15;438(2):114061
High expression of B7-H3 on monocyte/macrophages in tumor microenvironment promotes lung cancer progression by inhibiting apoptosis.
Zhang D, Huang H, Gao X, Yu G, Zhang X, Jin H, Xu R, Wang Z, Zhang G
Translational oncology 2024 Mar;41:101874
Translational oncology 2024 Mar;41:101874
Shuganning Injection Suppresses Apoptosis for Protecting Against Cantharidin-Induced Liver Injury by Network Pharmacology and Experiment Validation.
Duan X, Ao J, Yu M, Li S, Li X, Zhang J
ACS omega 2024 Mar 26;9(12):13692-13703
ACS omega 2024 Mar 26;9(12):13692-13703
A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
Xue M, Xing L, Yang Y, Shao M, Liao F, Xu F, Chen Y, Wang S, Chen B, Yao C, Gu G, Tong C
BMC cardiovascular disorders 2024 Mar 26;24(1):180
BMC cardiovascular disorders 2024 Mar 26;24(1):180
Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway.
Sun X, Pan Y, Luo Y, Guo H, Zhang Z, Wang D, Li C, Sun X
Journal of ethnopharmacology 2024 Mar 25;322:117672
Journal of ethnopharmacology 2024 Mar 25;322:117672
Defective autophagy contributes to bupivacaine-induced aggravation of painful diabetic neuropathy in db/db mice.
Fan K, Liao Q, Yuan P, Xu R, Liu Z
Neuropharmacology 2024 Mar 1;245:109814
Neuropharmacology 2024 Mar 1;245:109814
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Wang L, Zhuang J, Xue Z, Lu H, Zeng W, Zhang T
Journal of food science 2024 Jun;89(6):3858-3870
Journal of food science 2024 Jun;89(6):3858-3870
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Yan H, Ding J, Li X, Li S, Zhang D
Environmental toxicology 2024 Jun;39(6):3410-3424
Environmental toxicology 2024 Jun;39(6):3410-3424
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage.
Wu Q, Yuan K, Yao Y, Yao J, Shao J, Meng Y, Wu P, Shi H
Experimental neurology 2024 Jun;376:114776
Experimental neurology 2024 Jun;376:114776
Effect of black cloth ointment on hypertrophic scar formation: An investigation using integrated network pharmacology and animal assay.
Guo Q, Ji J, Chen F, Shi J, Liu H, Zhu C
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Jun;30(6):e13791
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Jun;30(6):e13791
Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT.
Li X, Wang Y, Wang X, Shen Y, Yuan Y, He Q, Mao S, Wu C, Zhou M
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2024 Jun;23(6):1051-1065
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2024 Jun;23(6):1051-1065
Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd.
Peng HX, Chai F, Chen KH, Huang YX, Wei GJ, Yuan H, Pang YF, Luo SH, Wang CF, Chen WC
Biological trace element research 2024 Jun;202(6):2616-2629
Biological trace element research 2024 Jun;202(6):2616-2629
Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma.
He Y, Wu S, Rietveld M, Vermeer M, Cruz LJ, Eich C, El Ghalbzouri A
Biomaterials advances 2024 Jun;160:213831
Biomaterials advances 2024 Jun;160:213831
CircZfp644-205 inhibits osteoblast differentiation and induces apoptosis of pre-osteoblasts via sponging miR-455-3p and promoting SMAD2 expression.
Zhang P, Liu J, Chai Z, Fu J, Li S, Yang Z
European journal of medical research 2024 Jun 8;29(1):315
European journal of medical research 2024 Jun 8;29(1):315
O-GlcNAc Modification Is a Promising Therapeutic Target for Diabetic Retinopathy.
Dong W, Imdad L, Xu S, Wang Y, Liu C, Song S, Li Z, Kong Y, Kong L, Ren X
International journal of molecular sciences 2024 Jun 6;25(11)
International journal of molecular sciences 2024 Jun 6;25(11)
Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora.
Li Y, He P, Chen Y, Hu J, Deng B, Liu C, Yu B, Dong W
Scientific reports 2024 Jun 6;14(1):13063
Scientific reports 2024 Jun 6;14(1):13063
2'-Hydroxycinnamaldehyde Alleviates Intestinal Inflammation by Attenuating Intestinal Mucosal Barrier Damage Via Directly Inhibiting STAT3.
Chen M, Wei S, Wu X, Xiang Z, Li X, He H, Liao F, Wang X, Zhang J, Yu B, Dong W
Inflammatory bowel diseases 2024 Jun 3;30(6):992-1008
Inflammatory bowel diseases 2024 Jun 3;30(6):992-1008
Study on the mechanism of S100A4-mediated cancer oncogenesis in uveal melanoma cells through the integration of bioinformatics and in vitro experiments.
Chen H, Zhang W, Shi J, Tang Y, Chen X, Li J, Yao X
Gene 2024 Jun 15;911:148333
Gene 2024 Jun 15;911:148333
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity.
Zhu W, Lian N, Wang J, Zhao F, Liu B, Sheng J, Zhang C, Zhou X, Gao W, Xie C, Gu H, Zhang Y, Bian M, Jiang M, Li Y
Chinese medicine 2024 Jun 14;19(1):85
Chinese medicine 2024 Jun 14;19(1):85
Evolocumab prevents atrial fibrillation in rheumatoid arthritis rats through restraint of PCSK9 induced atrial remodeling.
Han X, Gao Y, He M, Luo Y, Wei Y, Duan Y, Zhang S, Yu H, Kan J, Hou T, Zhang Y, Li Y
Journal of advanced research 2024 Jul;61:211-221
Journal of advanced research 2024 Jul;61:211-221
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2(+) axis.
Li JH, Wan HX, Wu LH, Fang F, Wang JX, Dong H, Xu F
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
FUDNC1-dependent mitophagy ameliorate motor neuron death in an amyotrophic lateral sclerosis mouse model.
Guo X, Zhang Z, Gu J, Ke P, Liu J, Meng Y, Zheng W, Que W, Fan R, Luo J, Xiao F
Neurobiology of disease 2024 Jul;197:106534
Neurobiology of disease 2024 Jul;197:106534
THSG alleviates cerebral ischemia/reperfusion injury via the GluN2B-CaMKII-ERK1/2 pathway.
Liu T, Shi J, Wu D, Li D, Wang Y, Liu J, Meng P, Hu L, Fu C, Mei Z, Ge J, Zhang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155595
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155595
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization.
Yang Y, Zhao C, Yang Z, Du C, Chang Z, Wen X, Zhang X, Liu Y, Hu L, Gao Z
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Journal of molecular medicine (Berlin, Germany) 2024 Jul;102(7):875-886
Thioredoxin-1 and its mimetic peptide improve systolic cardiac function and remodeling after myocardial infarction.
Medali T, Couchie D, Mougenot N, Mihoc M, Bergmann O, Derks W, Szweda LI, Yacoub M, Soliman S, Aguib Y, Wagdy K, Ibrahim AM, Friguet B, Rouis M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23291
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23291
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Wei X, Ni J, Yuan L, Li X
Oncology letters 2024 Jan;27(1):17
Oncology letters 2024 Jan;27(1):17
A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis.
Zhao D, He J, Zhao X, Sheng X, Feng Z, Wang X, Zhang C, Wang S, Geng B, Xia Y
International journal of biological macromolecules 2024 Jan;254(Pt 2):127824
International journal of biological macromolecules 2024 Jan;254(Pt 2):127824
NaAsO(2) regulates TLR4/MyD88/NF-κB signaling pathway through DNMT1/SOCS1 to cause apoptosis and inflammation in hepatic BRL-3A cells.
Li S, Zhang J, Ma M, Zhang M, Li L, Chen W, Li S
Biological trace element research 2024 Jan;202(1):258-267
Biological trace element research 2024 Jan;202(1):258-267
Understanding apoptotic induction by Sargentodoxa cuneata-Patrinia villosa herb pair via PI3K/AKT/mTOR signalling in colorectal cancer cells using network pharmacology and cellular studies.
Mu BX, Li Y, Ye N, Liu S, Zou X, Qian J, Wu C, Zhuang Y, Chen M, Zhou JY
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117342
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117342
Neuroprotective Effect of Zishen Huoxue Decoction treatment on Vascular Dementia by activating PINK1/Parkin mediated Mitophagy in the Hippocampal CA1 Region.
Zhao Z, Xie L, Shi J, Liu T, Wang S, Huang J, Wu D, Zhang X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117172
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117172
Dietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis.
Wei Y, Li J, Li J, Liu C, Guo X, Liu Z, Zhang L, Bao S, Wu X, Su W, Wang X, Zhang J, Dong W
Cell death & disease 2024 Jan 17;15(1):60
Cell death & disease 2024 Jan 17;15(1):60
Metformin protects ovarian granulosa cells in chemotherapy-induced premature ovarian failure mice through AMPK/PPAR-γ/SIRT1 pathway.
Yang Y, Tang X, Yao T, Zhang Y, Zhong Y, Wu S, Wang Y, Pan Z
Scientific reports 2024 Jan 16;14(1):1447
Scientific reports 2024 Jan 16;14(1):1447
Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling.
Xia B, Ding J, Li Q, Zheng K, Wu J, Huang C, Liu K, You Q, Yuan X
International journal of cardiology 2024 Jan 15;395:131426
International journal of cardiology 2024 Jan 15;395:131426
SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus.
Ye X, Lin JY, Chen LX, Wu XC, Ma KJ, Li BX, Fang YX
Heliyon 2024 Jan 15;10(1):e23945
Heliyon 2024 Jan 15;10(1):e23945
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1.
An Y, Zhang Q, Chen Y, Xia F, Wong YK, He H, Hao M, Tian J, Zhang X, Luo P, Wang J
Advanced biology 2024 Feb;8(2):e2300538
Advanced biology 2024 Feb;8(2):e2300538
Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.
Chen J, Zhao T, Zheng X, Kang L, Wang J, Wei Y, Wu Y, Shen L, Long C, Wei G, Wu S
Environmental toxicology 2024 Feb;39(2):952-964
Environmental toxicology 2024 Feb;39(2):952-964
Discovery of Novel Marine-Derived Phidiandine/Lipoic Acid Hybrid as a Potential Anti-Atherosclerosis Agent: Design, Synthesis and in Vitro/in Vivo Evaluation.
Liu SJ, Zhong YN, Cheng ZQ, Meng N, Zhang J, Jiang CS
Chemistry & biodiversity 2024 Feb;21(2):e202301371
Chemistry & biodiversity 2024 Feb;21(2):e202301371
The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization.
Chen Y, Zhu S, Liao T, Wang C, Han J, Yang Z, Lu X, Hu Z, Hu J, Wang X, Gu M, Gao R, Liu K, Liu X, Ding C, Hu S, Liu X
PLoS pathogens 2024 Feb;20(2):e1011981
PLoS pathogens 2024 Feb;20(2):e1011981
Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Xing D, Jin Y, Sun D, Liu Y, Cai B, Gao C, Cui Y, Jin B
Archives of gerontology and geriatrics 2024 Feb;117:105274
Archives of gerontology and geriatrics 2024 Feb;117:105274
Sulbactam protects neurons against double neurotoxicity of amyloid beta and glutamate load by upregulating glial glutamate transporter 1.
Li L, Li W, Jiang W, Xu R
Cell death discovery 2024 Feb 6;10(1):64
Cell death discovery 2024 Feb 6;10(1):64
Tetrandrine downregulates TRPV2 expression to ameliorate myocardial ischemia/reperfusion injury in rats via regulation of cardiomyocyte apoptosis, calcium homeostasis and mitochondrial function.
Jiang L, Zhou X, Zhao X, Wang Z, Huang A, Huang Y, Sun H, Guan F, Jiang W
European journal of pharmacology 2024 Feb 5;964:176246
European journal of pharmacology 2024 Feb 5;964:176246
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
Huang Y, Chan S, Chen S, Liu X, Li M, Zheng L, Dong Z, Yang Z, Liu Z, Zhou D, Zhang X, Zhang B
Journal of translational medicine 2024 Feb 3;22(1):133
Journal of translational medicine 2024 Feb 3;22(1):133
ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling.
Liu S, Xie J, Duan C, Zhao X, Feng Z, Dai Z, Luo X, Li Y, Yang M, Zhuang R, Li J, Yin W
Journal of clinical and translational hepatology 2024 Feb 28;12(2):134-150
Journal of clinical and translational hepatology 2024 Feb 28;12(2):134-150
Complanatuside A improves functional recovery after spinal cord injury through inhibiting JNK signaling-mediated microglial activation.
Xu Y, Geng Z, Sun Y, Zhu G, Xiao L, Wang Z, Li B, Liu X, Shi J, Song X, Hu J, Qi Q
European journal of pharmacology 2024 Feb 15;965:176287
European journal of pharmacology 2024 Feb 15;965:176287
DPY30 knockdown suppresses colorectal carcinoma progression via inducing Raf1/MST2-mediated apoptosis.
Jiang H, Su W, Wang H, Luo C, Wang Y, Zhang L, Luo L, Lu Z, Shen D, Su G
Heliyon 2024 Feb 15;10(3):e24807
Heliyon 2024 Feb 15;10(3):e24807
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.
Chen SJ, Ren LK, Fei XB, Liu P, Wang X, Zhu CH, Pan YZ
Aging 2024 Feb 1;16(3):2617-2637
Aging 2024 Feb 1;16(3):2617-2637
Inhibition of XPR1-dependent phosphate efflux induces mitochondrial dysfunction: A potential molecular target therapy for hepatocellular carcinoma?
Liao ZQ, Lv YF, Kang MD, Ji YL, Liu Y, Wang LR, Tang JL, Deng ZQ, Yi Y, Tang Q
Molecular carcinogenesis 2024 Dec;63(12):2332-2345
Molecular carcinogenesis 2024 Dec;63(12):2332-2345
Amitraz mechanisms of cytotoxicity in a characterized SH-SY5Y cells spheroid model.
Franco-Campos F, Fernández-Franzón M, Rodríguez-Carrasco Y, Ruiz MJ
Toxicology 2024 Dec;509:153987
Toxicology 2024 Dec;509:153987
Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells.
Wang L, Sun S, Liu H, Zhang Q, Meng Y, Sun F, Zhang J, Liu H, Xu W, Ye Z, Zhang J, Sun B, Xu J
The FEBS journal 2024 Dec;291(23):5276-5289
The FEBS journal 2024 Dec;291(23):5276-5289
FL118: A potential bladder cancer therapeutic compound targeting H2A.X identified through library screening.
Fan G, Luo X, Shi Y, Wang Y, Ji L, Gong Y, Yang E, Chen C, Cui S, Ding H, Zhang Z, Wang J, Liu Y, Wang Z
Bioorganic chemistry 2024 Dec;153:107802
Bioorganic chemistry 2024 Dec;153:107802
Exploring the mechanism of carbamazepine decreasing testosterone levels based on cAMP/PKA/CREB pathway.
Li J, Liu Z, Pan M, Li L, Tong X, Wang Y, Chen B, Wang T
3 Biotech 2024 Dec;14(12):305
3 Biotech 2024 Dec;14(12):305
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.
Liu L, Zheng C, Xu Z, Wang Z, Zhong Y, He Z, Zhang W, Zhang Y
Microbiology spectrum 2024 Dec 5;12(12):e0210824
Microbiology spectrum 2024 Dec 5;12(12):e0210824
Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study.
Wang X, Tian W, Wang N, Yang X, Liu Z, Li L, Zhao T, Wang C, Zhang H, Yang H, Jia Y
BMC cancer 2024 Dec 30;24(1):1593
BMC cancer 2024 Dec 30;24(1):1593
Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway.
Geng Q, Wu W, Yang M, Gu F, Cai W, Qin Y, Wei L, Wang H, Li N
Heliyon 2024 Dec 30;10(24):e39987
Heliyon 2024 Dec 30;10(24):e39987
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Zhou Z, Xu L, Lv Y, Li L, Yuan H, Hu F
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
Protective effect of metformin on the NG-nitro-l-arginine methyl ester (l-NAME)-induced rat models of preeclampsia.
Hao H, Li F, Wang F, Ran J, Chen Y, Yang L, Ma H, Wang J, Yang H
Biochemical and biophysical research communications 2024 Dec 20;739:150996
Biochemical and biophysical research communications 2024 Dec 20;739:150996
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway.
Chang J, Yao Y, Sun X, Wang W, Qian H, Liu Y, Xue C, Ye W, Jiang F
Cell biology and toxicology 2024 Dec 20;41(1):1
Cell biology and toxicology 2024 Dec 20;41(1):1
FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.
Shao L, Kong X, Lv S, Shu X, Ma X, Ai X, Yan D, Ying Y
Cell death & disease 2024 Dec 20;15(12):920
Cell death & disease 2024 Dec 20;15(12):920
Butyrolactone-I from Marine Fungal Metabolites Mitigates Heat-Stress-Induced Apoptosis in IPEC-J2 Cells and Mice Through the ROS/PERK/CHOP Signaling Pathway.
Niu X, Chen S, Wang X, Wen J, Liu X, Yong Y, Yu Z, Ma X, Abd El-Aty AM, Ju X
Marine drugs 2024 Dec 17;22(12)
Marine drugs 2024 Dec 17;22(12)
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Inhibition of LSD1 via SP2509 attenuated the progression of rheumatoid arthritis.
Yu Z, Li P, Gao D, Hu Y, Xia F, Liu L, Liu J, Liu W, Zhang H
Immunologic research 2024 Aug;72(4):797-810
Immunologic research 2024 Aug;72(4):797-810
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer's Disease.
Wang XF, Xiang XH, Wei J, Zhang PB, Xu Q, Liu MH, Qu LQ, Wang XX, Yu L, Wu AG, Qing DL, Wu JM, Law BY, Yu CL, Yong-Tang
Neurochemical research 2024 Aug;49(8):2197-2214
Neurochemical research 2024 Aug;49(8):2197-2214
A novel recombinant adenovirus expressing apoptin and melittin genes kills hepatocellular carcinoma cells and inhibits the growth of ectopic tumor.
Wu J, Lan Z, Li X, He J, Zhang D, Jin T
Investigational new drugs 2024 Aug;42(4):428-441
Investigational new drugs 2024 Aug;42(4):428-441
Neuroprotective effects of exosomes derived from bone marrow mesenchymal stem cells treated by Musk Ketone on ischemic stroke.
Chen C, Feng D, Lu F, Qin J, Dun L, Liao Z, Tao J, Zhou Z
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Aug;33(8):107628
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Aug;33(8):107628
A2 reactive astrocyte-derived exosomes alleviate cerebral ischemia-reperfusion injury by delivering miR-628.
Wang Y, Li H, Sun H, Xu C, Sun H, Wei W, Song J, Jia F, Zhong D, Li G
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
Journal of cellular and molecular medicine 2024 Aug;28(16):e70004
A novel L-shaped ortho-quinone analog suppresses glioblastoma progression by targeting acceleration of AR degradation and regulating PI3K/AKT pathway.
Zhang T, Pan W, Tan X, Yu J, Cheng S, Wei S, Fan K, Wang L, Luo H, Hu X
Biochemical pharmacology 2024 Aug;226:116398
Biochemical pharmacology 2024 Aug;226:116398
Donor-Acceptor-Donor Strategy Rouses the Photodynamic Therapy Anticancer Activity of a Bis-terpyridyl Ru(II) Complex.
Wang Z, Wei L, Lin J, Huang C, Chen H, Fan D, Hu W, Liu J, Huang H, Wang Z, Wang X
Journal of medicinal chemistry 2024 Aug 8;67(15):13435-13445
Journal of medicinal chemistry 2024 Aug 8;67(15):13435-13445
Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring.
Tian L, Zhang Y, Chen J, Liu X, Nie H, Li K, Liu H, Lai W, Shi Y, Xi Z, Lin B
Journal of hazardous materials 2024 Aug 5;474:134800
Journal of hazardous materials 2024 Aug 5;474:134800
Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence.
Rai MF, Duan X, Yan M, Brophy RH, Cai L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e23862
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 31;38(16):e23862
Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis.
Zhang Z, Li B, Wu S, Yang Y, Wu B, Lai Q, Lai F, Mo F, Zhong Y, Wang S, Guo R, Zhang B
Scientific reports 2024 Aug 31;14(1):20292
Scientific reports 2024 Aug 31;14(1):20292
Emodin attenuates hypoxic-ischemic brain damage by inhibiting neuronal apoptosis in neonatal mice.
Guo Y, Chen Y, Zhang H, Zhang Q, Jin M, Wang S, Du X, Du Y, Xu D, Wang M, Li L, Luo L
Neuroscience 2024 Aug 30;554:83-95
Neuroscience 2024 Aug 30;554:83-95
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
Zheng H, Zhang X, Li C, Wang D, Shen Y, Lu J, Zhao L, Li X, Gao H
Microbiome 2024 Aug 24;12(1):157
Microbiome 2024 Aug 24;12(1):157
Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis.
Gao X, Gao N, Du M, Xiang Y, Zuo H, Cao H, Zheng S, Huang R, Wan W, Hu K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23878
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23878
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
Che Y, Lu X, Wang X, Liu Z, Guan L, Li X, Du Z, Ren H, Wang J, Zhou Z, Lv L
Cancer cell international 2024 Aug 14;24(1):290
Cancer cell international 2024 Aug 14;24(1):290
Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model.
Lin Y, Chen Q, Zhang G, Xie L, Yang X, Zhong H, Xu J, Zhang M
The American journal of emergency medicine 2024 Apr;78:48-56
The American journal of emergency medicine 2024 Apr;78:48-56
Rapamycin inhibits B16 melanoma cell viability invitro and invivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway.
Wang P, Zhang H, Guo K, Liu C, Chen S, Pu B, Chen S, Feng T, Jiao H, Gao C
Oncology letters 2024 Apr;27(4):140
Oncology letters 2024 Apr;27(4):140
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Wang TB, He Y, Li RC, Yu YX, Liu Y, Qi ZQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic-Gas Therapy.
Wang W, Gao Y, Xu J, Zou T, Yang B, Hu S, Cheng X, Xia Y, Zheng Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307143
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Cheng F, Zhang J, Yang P, Chen Z, Fu Y, Mi J, Xie X, Liu S, Sheng Y
Heliyon 2024 Apr 30;10(8):e29162
Heliyon 2024 Apr 30;10(8):e29162
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Wang X, Fu Y, Yang X, Chen Y, Zeng N, Hu S, Ouyang S, Pan X, Wu S
Scientific reports 2024 Apr 27;14(1):9723
Scientific reports 2024 Apr 27;14(1):9723
Connexin 43 Prevents Radiation-Induced Intestinal Damage via the Ca2+-Dependent PI3K/Akt Signaling Pathway.
Zhu Y, Dai J, Song B, Zhang Y, Yang T, Xu H, Xu X, Gao Y, Yan T, Shen W, Zhang W, Zhang S, Liu P
Radiation research 2024 Apr 1;201(4):294-303
Radiation research 2024 Apr 1;201(4):294-303
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Tan Z, Dong F, Wu L, Feng Y, Zhang M, Zhang F
Mediators of inflammation 2023;2023:5677865
Mediators of inflammation 2023;2023:5677865
Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition.
Yang X, Cao Q, Ma B, Xia Y, Liu M, Tian J, Chen J, Su C, Duan X
PloS one 2023;18(3):e0277155
PloS one 2023;18(3):e0277155
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Zhu Y, Sun W, Jiang X, Bai R, Luo Y, Gao Y, Li S, Huang Z, Gong Y, Xie C
PloS one 2023;18(1):e0281132
PloS one 2023;18(1):e0281132
Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway.
Wu L, Tan Z, Su L, Dong F, Xu G, Zhang F
Frontiers in cellular neuroscience 2023;17:1343842
Frontiers in cellular neuroscience 2023;17:1343842
Blockage of S100A8/A9 ameliorates septic nephropathy in mice.
Shi W, Wan TT, Li HH, Guo SB
Frontiers in pharmacology 2023;14:1172356
Frontiers in pharmacology 2023;14:1172356
Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE(-/-) mice with minimal side effects.
Zhang L, Wang C, Hu W, Bu T, Sun W, Zhou T, Qiu S, Wei M, Xing H, Li Z, Yang G, Yuan L
Theranostics 2023;13(14):5114-5129
Theranostics 2023;13(14):5114-5129
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells.
Song W, Qiu YT, Li XZ, Sun QY, Chen LN
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105613
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105613
Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells.
Tang J, Lu X, Zhang T, Feng Y, Xu Q, Li J, Lan Y, Luo H, Zeng L, Xiang Y, Zhang Y, Li Q, Mao X, Tang B, Zeng D
Heliyon 2023 Sep;9(9):e20012
Heliyon 2023 Sep;9(9):e20012
Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway.
Dong J, Cui J, Shi X, Wang T, Liu S
Heliyon 2023 Sep;9(9):e19244
Heliyon 2023 Sep;9(9):e19244
Protective effect of Platycodon grandiflorus polysaccharide on apoptosis and mitochondrial damage induced by pseudorabies virus in PK-15 cells.
Xing Y, Cui Y, Xu G, Qi C, Zhang M, Cheng G, Liu Y, Liu J
Cell biochemistry and biophysics 2023 Sep;81(3):493-502
Cell biochemistry and biophysics 2023 Sep;81(3):493-502
Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells.
Luo Y, Hu N, Zhao Y, Lai J, Luo X, Liu J
Experimental and therapeutic medicine 2023 Sep;26(3):433
Experimental and therapeutic medicine 2023 Sep;26(3):433
The long noncoding RNA CIRBIL is a regulator of steroidogenesis in mice.
Huang X, Liu X, Zhang X, Yang Y, Gao H, Gao J, Bao H, Zhao L, Yang G, Zhang Y, Liu D
Reproductive biology 2023 Sep;23(3):100783
Reproductive biology 2023 Sep;23(3):100783
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Fang Z, Li Y, Wang J, Wang X, Huang L, Sun L, Deng Q
Biological trace element research 2023 Sep;201(9):4437-4446
Biological trace element research 2023 Sep;201(9):4437-4446
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Wang J, He P, Tian Q, Luo Y, He Y, Liu C, Gong P, Guo Y, Ye Q, Li M
Neural regeneration research 2023 Sep;18(9):2029-2036
Neural regeneration research 2023 Sep;18(9):2029-2036
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Xia B, Li Q, Zheng K, Wu J, Huang C, Liu K, You Q, Yuan X
European journal of pharmacology 2023 Sep 5;954:175864
European journal of pharmacology 2023 Sep 5;954:175864
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.
Zou F, Chen W, Song T, Xing J, Zhang Y, Chen K, Hu W, Li L, Ning J, Li C, Yu W, Cheng F
Cancer cell international 2023 Sep 28;23(1):221
Cancer cell international 2023 Sep 28;23(1):221
Carbon Monoxide Releasing Molecule-3 Alleviates Oxidative Stress and Apoptosis in Selenite-Induced Cataract in Rats via Activating Nrf2/HO-1 Pathway.
Li J, Huang Y, Ma T, Liu Y, Luo Y, Gao L, Li Z, Ye Z
Current eye research 2023 Oct;48(10):919-929
Current eye research 2023 Oct;48(10):919-929
Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis.
Huang Y, Zhang L, Tan L, Zhang C, Li X, Wang P, Gao L, Zhao C
Inflammation 2023 Oct;46(5):1871-1886
Inflammation 2023 Oct;46(5):1871-1886
Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells.
Song Y, Sun W, Li W, Li W
International immunopharmacology 2023 Oct;123:110751
International immunopharmacology 2023 Oct;123:110751
Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1/Foxo3a pathway.
Xiu Z, Tang S, Kong P, Yan M, Tong X, Liu X, Liang X, Li R, Duan Y
Journal of ethnopharmacology 2023 Oct 5;314:116608
Journal of ethnopharmacology 2023 Oct 5;314:116608
Effects of iguratimod on inflammatory factors and apoptosis of submandibular gland epithelial cells in NOD mice.
Wang S, Yu J, Yang J, Ge Y, Tian J
Scientific reports 2023 Oct 24;13(1):18205
Scientific reports 2023 Oct 24;13(1):18205
Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer.
Li W, Li D, Ma Q, Chen Y, Hu Z, Bai Y, Xie L
European journal of pharmacology 2023 Oct 15;957:176035
European journal of pharmacology 2023 Oct 15;957:176035
Metformin alleviates cerebral ischemia/reperfusion injury aggravated by hyperglycemia via regulating AMPK/ULK1/PINK1/Parkin pathway-mediated mitophagy and apoptosis.
Guo Y, Jiang H, Wang M, Ma Y, Zhang J, Jing L
Chemico-biological interactions 2023 Oct 1;384:110723
Chemico-biological interactions 2023 Oct 1;384:110723
Reactive oxygen species-mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force.
Yan M, Zhang Y, Niu W, Liu K, Xue L, Zhou K
Microscopy research and technique 2023 Nov;86(11):1529-1541
Microscopy research and technique 2023 Nov;86(11):1529-1541
Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice.
Xiang XH, Wei J, Wang XF, Xu Q, Yu CL, He CL, Long T, Guo MS, Chen X, Zhou XG, Wu JM, Qin DL, Wu AG, Tang Y, Lv HB
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115478
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115478
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis.
Teng H, Wu D, Lu L, Gao C, Wang H, Zhao Y, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115452
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115452
IL-7 promotes CD19-directed CAR-T cells proliferation through miRNA-98-5p by targeting CDKN1A.
Yang LR, Li L, Meng MY, Li TT, Zhao YY, Yang SL, Gao H, Tang WW, Yang Y, Yang LL, Wang WJ, Liao LW, Hou ZL
International immunopharmacology 2023 Nov;124(Pt B):110974
International immunopharmacology 2023 Nov;124(Pt B):110974
A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3.
Tan X, Ma X, Dai Y, An J, Yu X, Li S, Liao Y, Pei T, Tang Y, Gui Y, Zhou S, Guo D, Deng Y, Hu K, Wang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155031
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155031
Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome.
Yan S, Gao Z, Ding J, Chen S, Wang Z, Jin W, Qu B, Zhang Y, Yang L, Guo D, Yin T, Yang Y, Zhang Y, Yang J
Journal of nanobiotechnology 2023 Nov 7;21(1):412
Journal of nanobiotechnology 2023 Nov 7;21(1):412
DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK.
Shi L, Zha H, Pan Z, Wang J, Xia Y, Li H, Huang H, Yue R, Song Z, Zhu J
Cell death & disease 2023 Nov 7;14(11):724
Cell death & disease 2023 Nov 7;14(11):724
Attenuation of estrogen and its receptors in the post-menopausal stage exacerbates dyslipidemia and leads to cognitive impairment.
Meng Q, Chao Y, Zhang S, Ding X, Feng H, Zhang C, Liu B, Zhu W, Li Y, Zhang Q, Tong H, Wu L, Bian H
Molecular brain 2023 Nov 20;16(1):80
Molecular brain 2023 Nov 20;16(1):80
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Xi Y, Chi Z, Tao X, Zhai X, Zhao Z, Ren J, Yang S, Dong D
Environmental toxicology 2023 May;38(5):1153-1161
Environmental toxicology 2023 May;38(5):1153-1161
Virulence assessment of four Glaesserella parasuis strains isolated in Liaoning province of China.
Yan P, Jia YC, Zhang XL, Zhou YY, Guo Y, Yin RL, Yuan J, Wang LX, Guo ZB, Wang JY, Wang X, Yin RH
Research in veterinary science 2023 May;158:226-234
Research in veterinary science 2023 May;158:226-234
Expression of αA-crystallin (CRYAA) in vivo and in vitro models of age-related cataract and the effect of its silencing on HLEB3 cells.
Ma X, Nan Y, Huang C, Li X, Yang Y, Jiang W, Ye M, Liu Q, Niu Y, Yuan L
Aging 2023 May 28;15(10):4498-4509
Aging 2023 May 28;15(10):4498-4509
Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway.
Yu X, Zhang Y, Pei K, Tan J, Tian H, Xu T, Liu F, Peng N, Huang Y, Huang X, Huang X, Wu J, Liu Q, Zeng L, Hua W, Huang X
Food & function 2023 May 11;14(9):4129-4142
Food & function 2023 May 11;14(9):4129-4142
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Zhao J, Liu J, Liu S, Tian S, Yuan H, Li S
Epigenomics 2023 Mar;15(6):369-383
Epigenomics 2023 Mar;15(6):369-383
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Chlorogenic Acid Alleviates Hepatic Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress, Inflammation, and Mitochondria-Mediated Apoptosis In Vivo and In Vitro.
Li K, Feng Z, Wang L, Ma X, Wang L, Liu K, Geng X, Peng C
Inflammation 2023 Jun;46(3):1061-1076
Inflammation 2023 Jun;46(3):1061-1076
Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation.
Li X, Lin Z, Wang P, Zhou C, Xu J, Lin J, Lin D, Zhang D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114731
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114731
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Mass spectrometry-based metabolomics reveal Dendrobium huoshanense polysaccharide effects and potential mechanism of N-methyl-N'-nitro-N-nitrosoguanidine -induced damage in GES-1 cells.
Xie H, Hu M, Yu J, Yang X, Li J, Yu N, Han L, Peng D
Journal of ethnopharmacology 2023 Jun 28;310:116342
Journal of ethnopharmacology 2023 Jun 28;310:116342
Network pharmacology, molecular docking and experimental verification help unravel chelerythrine's potential mechanism in the treatment of gastric cancer.
Kai K, Han-Bing J, Bing-Lin C, Shu-Jun Z
Heliyon 2023 Jul;9(7):e17393
Heliyon 2023 Jul;9(7):e17393
Nicotinamide Mononucleotide Adenylyl Transferase 2 Inhibition Aggravates Neurological Damage after Traumatic Brain Injury in a Rat Model.
Gu X, Ni H, Kan X, Chen C, Zhou Z, Ding Z, Li D, Liu B
Journal of Korean Neurosurgical Society 2023 Jul;66(4):400-408
Journal of Korean Neurosurgical Society 2023 Jul;66(4):400-408
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Deng X, Zeng Y, Qiu X, Zhong M, Xiong X, Luo M, Zhang J, Chen X
Leukemia research 2023 Jul;130:107312
Leukemia research 2023 Jul;130:107312
TFP5 attenuates cyclin-dependent kinase 5-mediated islet β-cell damage in diabetes.
Liu S, Li B, Ma D, Tao Y, Song J, Bao L, Zhang G, Luo H, Cao S, E J, Zheng Y
Chemical biology & drug design 2023 Jul;102(1):76-87
Chemical biology & drug design 2023 Jul;102(1):76-87
Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury.
Wu C, Wang L, Chen S, Shi L, Liu M, Tu P, Sun J, Zhao R, Zhang Y, Wang J, Pan Y, Ma Y, Guo Y
Journal of neuroinflammation 2023 Jul 22;20(1):171
Journal of neuroinflammation 2023 Jul 22;20(1):171
Lysophosphatidic acid is associated with oocyte maturation by enhancing autophagy via PI3K-AKT-mTOR signaling pathway in granulosa cells.
Liu J, Wang C
Journal of ovarian research 2023 Jul 11;16(1):137
Journal of ovarian research 2023 Jul 11;16(1):137
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
Chen Y, Dong Y, Zhang ZL, Han J, Chen FS, Tong XY, Ma H
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113
Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.
Shen K, Wu D, Sun B, Zhu Y, Wang H, Zou W, Ma Y, Lu Z
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
CNS neuroscience & therapeutics 2023 Jan;29(1):256-269
Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling.
Zhang MW, Li XT, Zhang ZZ, Liu Y, Song JW, Liu XM, Chen YH, Wang N, Guo Y, Liang LR, Zhong JC
Cell stress & chaperones 2023 Jan;28(1):91-103
Cell stress & chaperones 2023 Jan;28(1):91-103
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.
Li J, Sun X, Yang N, Ni J, Xie H, Guo H, Wang X, Zhou L, Liu J, Chen S, Wang X, Zhang Y, Yu C, Zhang W, Lu L
Kidney international 2023 Jan;103(1):115-133
Kidney international 2023 Jan;103(1):115-133
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Ma M, Luan X, Zheng H, Wang X, Wang S, Shen T, Ren D
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins.
Yi T, Qian J, Ye Y, Zhang H, Jin X, Wang M, Yang Z, Zhang W, Wen L, Zhang Y
ACS applied materials & interfaces 2023 Jan 11;15(1):511-523
ACS applied materials & interfaces 2023 Jan 11;15(1):511-523
Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer.
Qu YM, Chen A, Zhao X, Wang Z, Guo D, Shao SL, Tao YY, Li QJ, Wang MY, Ma WS
Molecular biology reports 2023 Feb;50(2):1517-1531
Molecular biology reports 2023 Feb;50(2):1517-1531
Renal transporter OAT1 and PPAR-α pathway co-contribute to icaritin-induced nephrotoxicity.
Wang D, Liu J, Chen X, Chen J, Zhao T, Du J, Wang C, Meng Q, Sun H, Wang F, Liu K, Wu J
Phytotherapy research : PTR 2023 Feb;37(2):549-562
Phytotherapy research : PTR 2023 Feb;37(2):549-562
PM2.5 exposure exacerbates mice thoracic aortic aneurysm and dissection by inducing smooth muscle cell apoptosis via the MAPK pathway.
Ming Y, Zhou X, Liu G, Abudupataer M, Zhu S, Xiang B, Yin X, Lai H, Sun Y, Wang C, Li J, Zhu K
Chemosphere 2023 Feb;313:137500
Chemosphere 2023 Feb;313:137500
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy.
Jiang B, Feng L, Yang T, Guo W, Li Y, Wang T, Liu C, Su H
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats.
Duan J, Yuan W, Jiang J, Wang J, Yan X, Liu F, Liu A
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay.
Liu J, Wu Y, Yang G, Liu Z, Liu X
Journal of inorganic biochemistry 2023 Feb;239:112069
Journal of inorganic biochemistry 2023 Feb;239:112069
YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice.
Huang P, Liu M, Zhang J, Zhong X, Zhong C
International journal of molecular sciences 2023 Feb 20;24(4)
International journal of molecular sciences 2023 Feb 20;24(4)
Spinal cord tissue engineering via covalent interaction between biomaterials and cells.
Liu W, Xu B, Zhao S, Han S, Quan R, Liu W, Ji C, Chen B, Xiao Z, Yin M, Yin Y, Dai J, Zhao Y
Science advances 2023 Feb 10;9(6):eade8829
Science advances 2023 Feb 10;9(6):eade8829
METTL3 depletion contributes to tumour progression and drug resistance via N6 methyladenosine-dependent mechanism in HR+HER2-breast cancer.
Ouyang D, Hong T, Fu M, Li Y, Zeng L, Chen Q, He H, Wen Y, Cheng Y, Zhou M, Zou Q, Yi W
Breast cancer research : BCR 2023 Feb 10;25(1):19
Breast cancer research : BCR 2023 Feb 10;25(1):19
MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells.
Hu Z, Linn N, Li Q, Zhang K, Liao J, Han Q, Zhang H, Guo J, Hu L, Pan J, Li Y, Tang Z
The Science of the total environment 2023 Feb 1;858(Pt 3):160157
The Science of the total environment 2023 Feb 1;858(Pt 3):160157
Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.
Chen C, Fan P, Zhang L, Xue K, Hu J, Huang J, Lu W, Xu J, Xu S, Qiu G, Ran J, Gan S
Neuroscience 2023 Feb 1;510:95-108
Neuroscience 2023 Feb 1;510:95-108
Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway.
Ding L, Zhu H, Wang K, Huang R, Yu W, Yan B, Zhou B, Wang H, Yang Z, Liu Z, Wang J
Environmental science and pollution research international 2023 Dec;30(60):125790-125805
Environmental science and pollution research international 2023 Dec;30(60):125790-125805
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery.
Xiao S, Huang S, Yang X, Lei Y, Chang M, Hu J, Meng Y, Zheng G, Chen X
Drug delivery 2023 Dec;30(1):2162156
Drug delivery 2023 Dec;30(1):2162156
hsa-miR-1301-3p Promotes the Proliferation and Migration of Nonsmall Cell Lung Cancer Cells and Reduces Radiosensitivity via Targeting Homeodomain-Only Protein Homeobox.
Qu M, Jin Z, Xu Y, Sun W, Luo Y, Zhang N, Huang Z, Han L, Gong Y, Xie C
Genetic testing and molecular biomarkers 2023 Dec;27(12):393-405
Genetic testing and molecular biomarkers 2023 Dec;27(12):393-405
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P
Biochemical genetics 2023 Aug;61(4):1265-1281
Biochemical genetics 2023 Aug;61(4):1265-1281
OGG1 aggravates renal ischemia-reperfusion injury by repressing PINK1-mediated mitophagy.
Zhao F, Zhu J, Zhang M, Luo Y, Li Y, Shi L, Huang J, Shadekejiang H, Dong S, Wu X
Cell proliferation 2023 Aug;56(8):e13418
Cell proliferation 2023 Aug;56(8):e13418
Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1.
Chen F, Sun M, Peng F, Lai Y, Jiang Z, Zhang W, Li T, Jing X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Aug;41(8):1792-1802
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2023 Aug;41(8):1792-1802
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation.
Wang J, Ji Y, Ai C, Chen JR, Gan D, Zhang J, Mo JQ, Guan MX
Journal of biomedical science 2023 Aug 3;30(1):63
Journal of biomedical science 2023 Aug 3;30(1):63
Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN.
Zhang Q, Chen L, Gao M, Wang S, Meng L, Guo L
Molecular and cellular biochemistry 2023 Apr;478(4):767-780
Molecular and cellular biochemistry 2023 Apr;478(4):767-780
MiR-155 promotes inflammation and apoptosis via targeting SIRT1 in hypoxic-ischemic brain damage.
Ke F, Wang H, Geng J, Jing X, Fang F, Fang C, Zhang BH
Experimental neurology 2023 Apr;362:114317
Experimental neurology 2023 Apr;362:114317
Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury.
Wu Q, Fang Y, Huang X, Zheng F, Ma S, Zhang X, Han T, Gao H, Shen B
International journal of molecular sciences 2023 Apr 6;24(7)
International journal of molecular sciences 2023 Apr 6;24(7)
Continuous Monochromatic Blue Light Exacerbates High-Fat Diet-Induced Kidney Injury via Corticosterone-Mediated Oxidative Stress.
Ren W, Wang Z, Cao J, Dong Y, Wang T, Chen Y
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Xu L, Cai J, Li C, Yang M, Duan T, Zhao Q, Xi Y, Sun L, He L, Tang C, Sun L
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Molecular medicine (Cambridge, Mass.) 2023 Apr 24;29(1):58
Anti-melanoma effect and action mechanism of a novel chitosan-based composite hydrogel containing hydroxyapatite nanoparticles.
Xu K, Wang Y, Xie Y, Zhang X, Chen W, Li Z, Wang T, Yang X, Guo B, Wang L, Zhu X, Zhang X
Regenerative biomaterials 2022;9:rbac050
Regenerative biomaterials 2022;9:rbac050
Integrated Bioinformatic Analysis Reveals TXNRD1 as a Novel Biomarker and Potential Therapeutic Target in Idiopathic Pulmonary Arterial Hypertension.
Lin W, Tang Y, Zhang M, Liang B, Wang M, Zha L, Yu Z
Frontiers in medicine 2022;9:894584
Frontiers in medicine 2022;9:894584
Systemically Silencing Long Non-coding RNAs Maclpil With Short Interfering RNA Nanoparticles Alleviates Experimental Ischemic Stroke by Promoting Macrophage Apoptosis and Anti-inflammatory Activation.
Wang Y, Liu C, Chen Y, Chen T, Han T, Xue L, Xu B
Frontiers in cardiovascular medicine 2022;9:876087
Frontiers in cardiovascular medicine 2022;9:876087
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Zou P, Zhang X, Zhang R, Chai X, Zhao Y, Li E, Zhang Q, Yan R, Yang J, Liao B
Frontiers in molecular biosciences 2022;9:853654
Frontiers in molecular biosciences 2022;9:853654
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Lou H, Zhang Y, Fang J, Jin Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation.
Zhang Y, Xing CJ, Liu X, Li YH, Jia J, Feng JG, Yang CJ, Chen Y, Zhou J
Oxidative medicine and cellular longevity 2022;2022:8645714
Oxidative medicine and cellular longevity 2022;2022:8645714
Pretreatment with Shenmai Injection Protects against Coronary Microvascular Dysfunction.
Zheng Z, Yu Z, Xu B, Zhou Y, Xing Y, Li Q, Tang W, Peng F
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8630480
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8630480
Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts.
Zeng Z, Xu L, Xu Y, Ruan Y, Liu D, Li J, Niu C, Zheng S, Zhou P, Xiao Z
Stem cells international 2022;2022:8513812
Stem cells international 2022;2022:8513812
The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury.
Tang W, Chai W, Du D, Xia Y, Wu Y, Jiang L, Cheng C, Guo Z, Sun X, Huang Z, Zhong J
Oxidative medicine and cellular longevity 2022;2022:8188404
Oxidative medicine and cellular longevity 2022;2022:8188404
Calycosin Improves Intestinal Mucosal Barrier Function after Gastrectomy in Rats through Alleviating Bacterial Translocation, Inflammation, and Oxidative Stress.
Peng H, Jin L, Zhang Q, Shen Y, Wang Z, Zhou F, Yu Q
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7412331
Evidence-based complementary and alternative medicine : eCAM 2022;2022:7412331
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.
Wei B, Hao Z, Zheng H, Qin Y, Zhao F, Shi L
Oxidative medicine and cellular longevity 2022;2022:5888636
Oxidative medicine and cellular longevity 2022;2022:5888636
Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation.
Zhang K, Zhou Z, Wang C, Yu M, Zhang Y, Shi Y, Wang X, Liu Y, Xu L, Shi W, Liu Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2624434
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2624434
Overexpression of Aquaporin-3 Alleviates Hyperosmolarity-Induced Nucleus Pulposus Cell Apoptosis via Regulating the ERK1/2 Pathway.
Zhang Z, Zhao C, Zhang R, Wang Y, Hu Y, Zhou Q, Li P
Pain research & management 2022;2022:1639560
Pain research & management 2022;2022:1639560
Hugan Buzure Induces Autophagy and Apoptosis in Hepatocellular Carcinoma by Inhibiting PI3K/Akt/mTOR Signaling Pathway.
Meng X, Li M, Qiao M, Li X, Yang J, Hu J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1618491
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1618491
Neuroprotective Mechanism of Icariin on Hypoxic Ischemic Brain Damage in Neonatal Mice.
Wang M, Yang X, Zhou Q, Guo Y, Chen Y, Song L, Yang J, Li L, Luo L
Oxidative medicine and cellular longevity 2022;2022:1330928
Oxidative medicine and cellular longevity 2022;2022:1330928
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease.
Feng J, Chen Z, Ma Y, Yang X, Zhu Z, Zhang Z, Hu J, Liang W, Ding G
International journal of biological sciences 2022;18(10):4026-4042
International journal of biological sciences 2022;18(10):4026-4042
Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death.
Xu X, Wang C, Zhang P, Gao X, Guan W, Wang F, Li X, Yuan J, Dou H, Xu G
International journal of biological sciences 2022;18(1):374-385
International journal of biological sciences 2022;18(1):374-385
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Fu Y, Yuan P, Zheng Y, Wei Y, Gao L, Ruan Y, Chen Y, Li P, Feng W, Zheng X
International journal of nanomedicine 2022;17:1549-1566
International journal of nanomedicine 2022;17:1549-1566
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Shu W, Wang Z, Zhao R, Shi R, Zhang J, Zhang W, Wang H
Drug design, development and therapy 2022;16:1847-1863
Drug design, development and therapy 2022;16:1847-1863
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction.
Guo J, Zhang L, Bu Y, Li W, Hu J, Li J
Frontiers in molecular neuroscience 2022;15:986710
Frontiers in molecular neuroscience 2022;15:986710
LncRNA PCAT19 induced by SP1 and acted as oncogene in gastric cancer competitively binding to miR429 and upregulating DHX9.
Xiao L, Yuan W, Huang C, Luo Q, Xiao R, Chen ZH
Journal of Cancer 2022;13(1):102-111
Journal of Cancer 2022;13(1):102-111
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1.
Yao E, Luo L, Lin C, Wen J, Li Y, Ren T, Chen Y, Huang J, Jin X
Frontiers in pharmacology 2022;13:964475
Frontiers in pharmacology 2022;13:964475
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Neddylation Inhibition Causes Impaired Mouse Embryo Quality and Blastocyst Hatching Failure Through Elevated Oxidative Stress and Reduced IL-1β.
Yang G, Chen J, He Y, Luo H, Yuan H, Chen L, Huang L, Mao F, Hu S, Qian Y, Miao C, Feng R
Frontiers in immunology 2022;13:925702
Frontiers in immunology 2022;13:925702
Sinomenine Confers Protection Against Myocardial Ischemia Reperfusion Injury by Preventing Oxidative Stress, Cellular Apoptosis, and Inflammation.
Xia B, Li Q, Wu J, Yuan X, Wang F, Lu X, Huang C, Zheng K, Yang R, Yin L, Liu K, You Q
Frontiers in pharmacology 2022;13:922484
Frontiers in pharmacology 2022;13:922484
SIRT1 Is Involved in the Neuroprotection of Pterostilbene Against Amyloid β 25-35-Induced Cognitive Deficits in Mice.
Zhu L, Lu F, Zhang X, Liu S, Mu P
Frontiers in pharmacology 2022;13:877098
Frontiers in pharmacology 2022;13:877098
Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From Scutellaria barbata D. Don.
Su W, Wu L, Liang Q, Lin X, Xu X, Yu S, Lin Y, Zhou J, Fu Y, Gao X, Zhang B, Li L, Li D, Yin Y, Song G
Frontiers in pharmacology 2022;13:827782
Frontiers in pharmacology 2022;13:827782
Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction.
Pan B, Xia Y, Fang S, Ai J, Wang K, Zhang J, Du C, Chen Y, Liu L, Yan S
Frontiers in pharmacology 2022;13:1043252
Frontiers in pharmacology 2022;13:1043252
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Zhou Z, Wei B, Liu Y, Liu T, Zeng S, Gan J, Qi G
Frontiers in genetics 2022;13:1035638
Frontiers in genetics 2022;13:1035638
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
Zhang J, Tang Z, Guo X, Wang Y, Zhou Y, Cai W
Frontiers in oncology 2022;12:933646
Frontiers in oncology 2022;12:933646
TRIM38 protects H9c2 cells from hypoxia/reoxygenation injury via the TRAF6/TAK1/NF-κB signalling pathway.
Lu Z, Deng M, Ma G, Chen L
PeerJ 2022;10:e13815
PeerJ 2022;10:e13815
Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.
Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X
PeerJ 2022;10:e13632
PeerJ 2022;10:e13632
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Wang H, Jiang C, Yang Y, Li J, Wang Y, Wang C, Gao Y
PeerJ 2022;10:e13592
PeerJ 2022;10:e13592
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Yuan D, Guo T, Qian H, Ge H, Zhao Y, Huang A, Wang X, Cao X, Zhu D, He C, Yu H
Drug development research 2022 Sep;83(6):1383-1393
Drug development research 2022 Sep;83(6):1383-1393
Trehalose improves palmitic acid-induced apoptosis of osteoblasts by regulating SIRT3-medicated autophagy via the AMPK/mTOR/ULK1 pathway.
Cao L, Zhou S, Qiu X, Qiu S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22491
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22491
Ursolic acid inhibits the activation of smoothened-independent non-canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade.
Chen L, Liu M, Yang H, Ren S, Sun Q, Zhao H, Ming T, Tang S, Tao Q, Zeng S, Meng X, Xu H
Phytotherapy research : PTR 2022 Sep;36(9):3555-3570
Phytotherapy research : PTR 2022 Sep;36(9):3555-3570
Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats.
Zhang D, Li L, Li J, Wei Y, Tang J, Man X, Liu F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113461
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113461
Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents.
Sun W, Sun F, Meng J, Cao X, Zhao S, Wang C, Li L, Jiang P
Bioorganic chemistry 2022 Sep;126:105906
Bioorganic chemistry 2022 Sep;126:105906
Fibroblast growth factor 21, a stress regulator, inhibits Drp1 activation to alleviate skeletal muscle ischemia/reperfusion injury.
Li B, Liu L
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):979-988
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):979-988
TFAP2C Knockdown Sensitizes Bladder Cancer Cells to Cisplatin Treatment via Regulation of EGFR and NF-κB.
Xing J, Chen W, Chen K, Zhu S, Lin F, Qi Y, Zhang Y, Han S, Rao T, Ruan Y, Zhao S, Yu W, Cheng F
Cancers 2022 Sep 30;14(19)
Cancers 2022 Sep 30;14(19)
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
Yu F, Tan W, Chen Z, Shen X, Mo X, Mo X, He J, Deng Z, Wang J, Luo Z, Yang J
Chinese medicine 2022 Sep 29;17(1):115
Chinese medicine 2022 Sep 29;17(1):115
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress.
Luo S, Yang M, Han Y, Zhao H, Jiang N, Li L, Chen W, Li C, Yang J, Liu Y, Liu C, Zhao C, Sun L
International immunopharmacology 2022 Oct;111:109101
International immunopharmacology 2022 Oct;111:109101
Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.
Tang X, Liang Y, Sun G, He Q, Hou Z, Jiang X, Gao P, Qu H
Cell death & disease 2022 Oct 4;13(10):848
Cell death & disease 2022 Oct 4;13(10):848
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Zhang D, Chang R, Ren Y, He Y, Guo S, Guan F, Yao M
International journal of biological macromolecules 2022 Oct 31;219:844-863
International journal of biological macromolecules 2022 Oct 31;219:844-863
Fucoxanthin induces apoptosis and reverses epithelial-mesenchymal transition via inhibiting Wnt/β-catenin pathway in lung adenocarcinoma.
Luan H, Yan L, Zhao Y, Ding X, Cao L
Discover oncology 2022 Oct 3;13(1):98
Discover oncology 2022 Oct 3;13(1):98
Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass.
Wu T, Shi G, Ji Z, Wang S, Geng L, Guo Z
Cellular & molecular biology letters 2022 Oct 25;27(1):95
Cellular & molecular biology letters 2022 Oct 25;27(1):95
The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.
Lu X, Huang X, Xu H, Lu S, You S, Xu J, Zhan Q, Dong C, Zhang N, Zhang Y, Cao L, Zhang X, Zhang N, Zhang L
Cell death discovery 2022 Oct 18;8(1):421
Cell death discovery 2022 Oct 18;8(1):421
Effect of muscone on anti-apoptotic ability of muskrat prostate primary cells.
Zhang Y, Zhao X, Man X, Ma Y, Zhang W, Wang Y, Lei X, Bai S
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Oct 1;323(4):R571-R580
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Oct 1;323(4):R571-R580
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Fang J, Ma Y, Li Y, Li J, Zhang X, Han X, Ma S, Guan F
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
Liu Y, Shi H, Hu Y, Yao R, Liu P, Yang Y, Li S
Cell stress & chaperones 2022 Nov;27(6):603-618
Cell stress & chaperones 2022 Nov;27(6):603-618
IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells.
Xiao H, Peng L, Jiang D, Liu Y, Zhu L, Li Z, Geng J, Xie B, Huang X, Wang J, Dai H, Wang C
Journal of cellular and molecular medicine 2022 Nov;26(22):5728-5741
Journal of cellular and molecular medicine 2022 Nov;26(22):5728-5741
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Du X, Zhang X, Dong J, Zou N, Guo D, Yao W, Wang X, Li S, Song C, Yan K, Shen W, Zhu S
Journal of translational medicine 2022 Nov 5;20(1):507
Journal of translational medicine 2022 Nov 5;20(1):507
Pt(IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity.
Yuan Y, Fu D, Xu Y, Wang X, Deng X, Zhou S, Du F, Cui X, Deng Y, Tang Z
Journal of medicinal chemistry 2022 Nov 24;65(22):15344-15357
Journal of medicinal chemistry 2022 Nov 24;65(22):15344-15357
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Xu H, Xu S, Li L, Wu Y, Mai S, Xie Y, Tan Y, Li A, Xue F, He X, Li Y
Chinese medicine 2022 Nov 24;17(1):131
Chinese medicine 2022 Nov 24;17(1):131
Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.
Zhong Y, Li Z, Jin R, Yao Y, He S, Lei M, Wang X, Shi C, Gao L, Peng X
Nutrients 2022 Nov 24;14(23)
Nutrients 2022 Nov 24;14(23)
Bioactive substances in the stratum corneum of the epidermis found as indicators of skin damage due to sun exposure.
Fukunaga A, Fukushima S, Iwata H, Nakahara M, Sasaki R, Baba N, Matsunaka H, Murakami Y, Furue M, Nishigori C
Photodermatology, photoimmunology & photomedicine 2022 May;38(3):241-249
Photodermatology, photoimmunology & photomedicine 2022 May;38(3):241-249
Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma.
Wang J, Xing W, Lin Y, Uskenbayeva N, Yan H, Xu Y, Fang L
Journal of clinical laboratory analysis 2022 May;36(5):e24435
Journal of clinical laboratory analysis 2022 May;36(5):e24435
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Cao Y, Li Y, Fu SC, Shen J, Zhang H, Jiang C, Shu-Hang Yung P
Journal of orthopaedic translation 2022 May;34:102-112
Journal of orthopaedic translation 2022 May;34:102-112
TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Cai J, Gao L, Wang Y, Li Y, Ye Z, Tong S, Yan T, Sun Q, Xu Y, Jiang H, Zhang S, Zhao L, Yang J, Chen Q
Translational oncology 2022 May;19:101391
Translational oncology 2022 May;19:101391
DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.
Wang J, Wang Y, Wang J, Zhang S, Yu Z, Zheng K, Fu Z, Wang C, Huang W, Chen J
Bioengineered 2022 May;13(5):13970-13985
Bioengineered 2022 May;13(5):13970-13985
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Tian Y, Wu H, Cao Y, Li R, Zou K, Xu W, Lu L
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Wang X, Li X, Xia Y, Wang D, Li X, Liu L, Zheng Q, Li D, Jiang Q
Journal of natural products 2022 May 27;85(5):1351-1362
Journal of natural products 2022 May 27;85(5):1351-1362
Leonurine Protects Bone Mesenchymal Stem Cells from Oxidative Stress by Activating Mitophagy through PI3K/Akt/mTOR Pathway.
Zhao B, Peng Q, Wang D, Zhou R, Wang R, Zhu Y, Qi S
Cells 2022 May 24;11(11)
Cells 2022 May 24;11(11)
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050
Diabetes 2022 May 1;71(5):1034-1050
miR-125b Disrupts Mitochondrial Dynamics via Targeting Mitofusin 1 in Cisplatin-Induced Acute Kidney Injury.
Zhao Y, Lang Y, Zhang M, Liang S, Zhu X, Liu Z
Kidney diseases (Basel, Switzerland) 2022 Mar;8(2):137-147
Kidney diseases (Basel, Switzerland) 2022 Mar;8(2):137-147
Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.
Hu Y, Zhang P, Shi Y, Dong X, Wu Y, Dong D, Li E, Fan Y
Environmental toxicology 2022 Mar;37(3):527-538
Environmental toxicology 2022 Mar;37(3):527-538
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Li Z, Xiao Z, Feng Y, Wang Q, Teng M
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Enhanced photodynamic therapy/photothermo therapy for nasopharyngeal carcinoma via a tumour microenvironment-responsive self-oxygenated drug delivery system.
Wu N, Tu Y, Fan G, Ding J, Luo J, Wang W, Zhang C, Yuan C, Zhang H, Chen P, Tan S, Xiao H
Asian journal of pharmaceutical sciences 2022 Mar;17(2):253-267
Asian journal of pharmaceutical sciences 2022 Mar;17(2):253-267
Effects of Ganfule capsule on microbial and metabolic profiles in anti-hepatocellular carcinoma.
Xu F, Li H, Pan Y, Zeng Y, Li J, Li S
Journal of applied microbiology 2022 Mar;132(3):2280-2292
Journal of applied microbiology 2022 Mar;132(3):2280-2292
Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
Liu Z, Zhou X, Zheng P, Bu C, Yan X, Yu H, Xu Y
Bioengineered 2022 Mar;13(3):6819-6838
Bioengineered 2022 Mar;13(3):6819-6838
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Guo H, Xiao Y, Yuan Z, Yang X, Chen J, Chen C, Wang M, Xie L, Chen Q, Tong Y, Zhang Q, Bai Y
Cell death discovery 2022 Mar 14;8(1):116
Cell death discovery 2022 Mar 14;8(1):116
Methylmercury induces lysosomal membrane permeabilization through JNK-activated Bax lysosomal translocation in neuronal cells.
Tianji L, Dingbang H, Xiao C, Xiaojing M, Fei Z, Bin W
Toxicology letters 2022 Mar 1;357:73-83
Toxicology letters 2022 Mar 1;357:73-83
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Yu X, Jiang N, Li J, Li X, He S
Tissue & cell 2022 Jun;76:101813
Tissue & cell 2022 Jun;76:101813
β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts.
Guo Q, Li Y, Chen Y, Ji J, Zheng S, Xu X, Zhang B, Ye J
IUBMB life 2022 Jun;74(6):508-518
IUBMB life 2022 Jun;74(6):508-518
LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy.
Zhang Q, Li D, Dong X, Zhang X, Liu J, Peng L, Meng B, Hua Q, Pei X, Zhao L, Hu X, Zhang Y, Pan Z, Lu Y, Yang B
Science China. Life sciences 2022 Jun;65(6):1198-1212
Science China. Life sciences 2022 Jun;65(6):1198-1212
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z
Cell biology and toxicology 2022 Jun;38(3):531-551
Cell biology and toxicology 2022 Jun;38(3):531-551
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Zhao J, Chen S, Yang C, Zhou M, Yang T, Sun B, Zhu J, Zhang H, Lu Q, Li L, Yang Z, Song B, Shen W, Yi S, Dai S
Biochemical pharmacology 2022 Jun;200:115047
Biochemical pharmacology 2022 Jun;200:115047
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Cai J, Liang J, Zhang Y, Shen L, Lin H, Hu T, Zhan S, Xie M, Liang S, Xian M, Wang S
Pharmacological research 2022 Jun;180:106230
Pharmacological research 2022 Jun;180:106230
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.
Fu Y, Yuan P, Zheng Y, Gao L, Wei Y, Chen Y, Li P, Ruan Y, Zheng X, Feng W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061
Limosilactobacillus reuteri SLZX19-12 Protects the Colon from Infection by Enhancing Stability of the Gut Microbiota and Barrier Integrity and Reducing Inflammation.
Wu J, Lin Z, Wang X, Zhao Y, Zhao J, Liu H, Johnston LJ, Lu L, Ma X
Microbiology spectrum 2022 Jun 29;10(3):e0212421
Microbiology spectrum 2022 Jun 29;10(3):e0212421
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Zhou M, Dai Y, Ma Y, Yan Y, Hua M, Gao Q, Geng X, Zhou Q
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Acrylonitrile exposure triggers ovarian inflammation and decreases oocyte quality probably via mitochondrial dysfunction induced apoptosis in mice.
Luo YS, He QK, Sun MX, Qiao FX, Liu YC, Xu CL, Xu ZR, Zhao SC, Wang HL, Qi ZQ, Liu Y
Chemico-biological interactions 2022 Jun 1;360:109934
Chemico-biological interactions 2022 Jun 1;360:109934
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Wu J, Yang C, Yang M, Liang Z, Wu Y, Kong X, Fan H, Wang S, Ning C, Xiao W, Jin Y, Yi J, Yuan Z
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway.
Yan J, Zhang F, Niu L, Wang X, Lu X, Ma C, Zhang C, Song J, Zhang Z
Brain research bulletin 2022 Jun 1;183:94-103
Brain research bulletin 2022 Jun 1;183:94-103
Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1.
Ding X, Sun J, Zhang X
Andrologia 2022 Jul;54(6):e14406
Andrologia 2022 Jul;54(6):e14406
Ophiopogonin D'-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells.
Lei S, Feng Y, Huang P, Chen B, Bao K, Wu Q, Zhang H, Huang X
Toxicology 2022 Jul;477:153275
Toxicology 2022 Jul;477:153275
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Huo K, Ma KG, Guo QY, Duan P, Xu J
International immunopharmacology 2022 Jul;108:108718
International immunopharmacology 2022 Jul;108:108718
Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells.
Wang T, Lei H, Zhou L, Tang M, Liu Q, Long F, Li Q, Su J
Toxins 2022 Jul 9;14(7)
Toxins 2022 Jul 9;14(7)
Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H(2)O(2) enhances their ability to treat intervertebral disc degeneration.
Zhang YY, Hu ZL, Qi YH, Li HY, Chang X, Gao XX, Liu CH, Li YY, Lou JH, Zhai Y, Li CQ
Stem cell research & therapy 2022 Jul 26;13(1):340
Stem cell research & therapy 2022 Jul 26;13(1):340
HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance.
Xie Y, Shi Z, Qian Y, Jiang C, Liu W, Liu B, Jiang B
Cancers 2022 Jul 23;14(15)
Cancers 2022 Jul 23;14(15)
Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.
Wang L, Cheng L, Ma L, Ahmad Farooqi A, Qiao G, Zhang Y, Ye H, Liu M, Huang J, Yang X, Lin X, Cao S
Phytotherapy research : PTR 2022 Jan;36(1):525-542
Phytotherapy research : PTR 2022 Jan;36(1):525-542
Thyroid stimulating hormone aggravates diabetic retinopathy through the mitochondrial apoptotic pathway.
Lin D, Qin R, Guo L
Journal of cellular physiology 2022 Jan;237(1):868-880
Journal of cellular physiology 2022 Jan;237(1):868-880
Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: in vitro and in vivo studies.
Wu X, Wang Y, Fan X, Xu X, Sun W
Aging 2022 Jan 7;14(1):410-429
Aging 2022 Jan 7;14(1):410-429
2-PMAP Ameliorates Cerebral Vasospasm and Brain Injury after Subarachnoid Hemorrhage by Regulating Neuro-Inflammation in Rats.
Wu CH, Tsai HP, Su YF, Tsai CY, Lu YY, Lin CL
Cells 2022 Jan 12;11(2)
Cells 2022 Jan 12;11(2)
Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo.
Kan Y, Song M, Cui X, Yang Q, Zang Y, Li Q, Li Y, Cai W, Chen Y, Weng X, Wang Y, Zhu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153834
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153834
Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways.
Zhang Y, Li Y, Wang Q, Zheng D, Feng X, Zhao W, Cai L, Zhang Q, Xu H, Fu H
International journal of molecular medicine 2022 Feb;49(2)
International journal of molecular medicine 2022 Feb;49(2)
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII.
Yang S, Liao W
Experimental and therapeutic medicine 2022 Feb;23(2):182
Experimental and therapeutic medicine 2022 Feb;23(2):182
PRUNE2 inhibits progression of colorectal cancer in vitro and in vivo.
Li T, Huang S, Yan W, Zhang Y, Guo Q
Experimental and therapeutic medicine 2022 Feb;23(2):169
Experimental and therapeutic medicine 2022 Feb;23(2):169
Cardiotoxicity of patulin was found in H9c2 cells.
Zhang B, Liang H, Huang K, Li J, Xu D, Huang C, Li Y
Toxicon : official journal of the International Society on Toxinology 2022 Feb;207:21-30
Toxicon : official journal of the International Society on Toxinology 2022 Feb;207:21-30
OLFM4 depletion sensitizes gallbladder cancer cells to cisplatin through the ARL6IP1/caspase-3 axis.
Lin Z, Yang S, Zhou Y, Hou Z, Li L, Meng M, Ge C, Zeng B, Lai J, Gao H, Zhao Y, Xie Y, He S, Tang W, Li R, Tan J, Wang W
Translational oncology 2022 Feb;16:101331
Translational oncology 2022 Feb;16:101331
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Fu Y, Gao J, Li Y, Yang X, Zhang Y
International immunopharmacology 2022 Feb;103:108414
International immunopharmacology 2022 Feb;103:108414
miR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2.
Xiang P, Hu J, Wang H, Luo Y, Gu C, Tan X, Tu Y, Guo W, Chen L, Gao L, Chen R, Yang J
Cell death discovery 2022 Feb 28;8(1):89
Cell death discovery 2022 Feb 28;8(1):89
Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner.
Wei JY, Hu MY, Chen XQ, Lei FY, Wei JS, Chen J, Qin XK, Qin YH
Renal failure 2022 Dec;44(1):2056-2065
Renal failure 2022 Dec;44(1):2056-2065
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Guan G, Zhang Q, Jiang Z, Liu J, Wan J, Jin P, Lv Q
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Varier KM, Dan G, Liu W, Wu G, Xiao C, Lei H, Ling T, Jiang Y, Chen Y, Ben-David Y, Li Y, Zhang N, Gajendran B, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Sesquiterpene lactones from Elephantopus scaber exhibit cytotoxic effects on glioma cells by targeting GSTP1.
Yan QL, Wang XY, Bai M, Zhang X, Song SJ, Yao GD
Bioorganic chemistry 2022 Dec;129:106183
Bioorganic chemistry 2022 Dec;129:106183
Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.
Ding N, Zhang Y, Huang M, Liu J, Wang C, Zhang C, Cao J, Zhang Q, Jiang L
Communications biology 2022 Dec 7;5(1):1339
Communications biology 2022 Dec 7;5(1):1339
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Tan J, Sun M, Yin J, Zhou Q, Zhao R, Chen Q, Sun H, Jiang C, Li S, He Y
Chemico-biological interactions 2022 Dec 1;368:110208
Chemico-biological interactions 2022 Dec 1;368:110208
Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice.
Wang Y, Wang Q, Duan L, Li X, Yang W, Huang T, Kong M, Guan F, Ma S
International journal of biological macromolecules 2022 Dec 1;222(Pt A):759-771
International journal of biological macromolecules 2022 Dec 1;222(Pt A):759-771
IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat Orthotopic Liver Transplantation Model.
Meng Q, Wu W, Zhang W, Yuan J, Yang L, Zhang X, Tao K
Biomolecules 2022 Dec 1;12(12)
Biomolecules 2022 Dec 1;12(12)
Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.
Luo Y, Zhang Y, Han X, Yuan Y, Zhou Y, Gao Y, Yu H, Zhang J, Shi Y, Duan Y, Zhao X, Yan S, Hao H, Dai C, Zhao S, Shi J, Li W, Zhang S, Xu W, Fang N, Gong Y, Li Y
EBioMedicine 2022 Aug;82:104087
EBioMedicine 2022 Aug;82:104087
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact.
Chai H, Zhang ZH, Fang JY, She C, Geng C, Xu W
Journal of cellular and molecular medicine 2022 Aug;26(15):4371-4385
Journal of cellular and molecular medicine 2022 Aug;26(15):4371-4385
Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin.
Wang J, Ding L, Wang K, Huang R, Yu W, Yan B, Wang H, Zhang C, Yang Z, Liu Z
Ecotoxicology and environmental safety 2022 Aug;241:113772
Ecotoxicology and environmental safety 2022 Aug;241:113772
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Wang K, Li Z, Sun Y, Liu X, Ma W, Ding Y, Hong J, Qian L, Xu D
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.
Jian Y, Yuan S, Yang J, Lei Y, Li X, Liu W
International journal of molecular sciences 2022 Aug 31;23(17)
International journal of molecular sciences 2022 Aug 31;23(17)
Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway.
Li J, Jiang R, Hou Y, Lin A
Biochemical and biophysical research communications 2022 Aug 27;618:133-140
Biochemical and biophysical research communications 2022 Aug 27;618:133-140
Breaking the Iron Homeostasis: A "Trojan Horse" Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition.
Li Y, Cen Y, Fang Y, Tang S, Li S, Ren Y, Zhang H, Lu W, Xu J
ACS nano 2022 Aug 23;16(8):12786-12800
ACS nano 2022 Aug 23;16(8):12786-12800
Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.
Huang L, An X, Zhu Y, Zhang K, Xiao L, Yao X, Zeng X, Liang S, Yu J
Cell communication and signaling : CCS 2022 Aug 16;20(1):122
Cell communication and signaling : CCS 2022 Aug 16;20(1):122
CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury.
Cao Y, Fan M, Pei Y, Su L, Xiao W, Chen F, Huang J, Liu X, Gu Z, Zhang Z, Yuan F, Jiang Y, Han X
Inflammation 2022 Apr;45(2):695-711
Inflammation 2022 Apr;45(2):695-711
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.
Xin X, Duan L, Yang H, Yu H, Bao Y, Jia D, Wu N, Qiao Y
Environmental toxicology 2022 Apr;37(4):741-753
Environmental toxicology 2022 Apr;37(4):741-753
GSK-3β-mediated activation of NLRP3 inflammasome leads to pyroptosis and apoptosis of rat cardiomyocytes and fibroblasts.
Wang SH, Cui LG, Su XL, Komal S, Ni RC, Zang MX, Zhang LR, Han SN
European journal of pharmacology 2022 Apr 5;920:174830
European journal of pharmacology 2022 Apr 5;920:174830
CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.
Feng X, Jiang J, Sun L, Zhou Q
Toxicology and applied pharmacology 2022 Apr 1;440:115940
Toxicology and applied pharmacology 2022 Apr 1;440:115940
Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway.
Cao Y, Chen Z, Hu J, Feng J, Zhu Z, Fan Y, Lin Q, Ding G
Frontiers in cell and developmental biology 2021;9:769213
Frontiers in cell and developmental biology 2021;9:769213
CTRP1 Attenuates Cerebral Ischemia/Reperfusion Injury via the PERK Signaling Pathway.
Fei H, Xiang P, Luo W, Tan X, Gu C, Liu M, Chen M, Wang Q, Yang J
Frontiers in cell and developmental biology 2021;9:700854
Frontiers in cell and developmental biology 2021;9:700854
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Dang NN, Li XB, Zhang M, Han C, Fan XY, Huang SH
Frontiers in cell and developmental biology 2021;9:662763
Frontiers in cell and developmental biology 2021;9:662763
Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway.
Ou G, Jiang X, Gao A, Li X, Lin Z, Pei S
Frontiers in veterinary science 2021;8:801407
Frontiers in veterinary science 2021;8:801407
Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure.
Liu Y, Liu P, Hu Y, Cao Y, Lu J, Yang Y, Lv H, Lian S, Xu B, Li S
Frontiers in molecular biosciences 2021;8:685993
Frontiers in molecular biosciences 2021;8:685993
Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling.
Zhang D, Li C, Zhang L, Li B, Wang Y, Wang R, Chen Z, Xu L, Liu T
Nutrition and cancer 2021;73(11-12):2491-2501
Nutrition and cancer 2021;73(11-12):2491-2501
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Yang X, Jin J, Yang J, Zhou L, Mi S, Qi G
Genetics and molecular biology 2021;44(4):e20210058
Genetics and molecular biology 2021;44(4):e20210058
Erteng-Sanjie Capsule Enhances Chemosensitivity of 5-Fluorouracil in Tumor-Bearing Nude Mice with Gastric Cancer by Inhibiting Notch1/Hes1 Signaling Pathway.
Zhou J, Hao S, Guo H, Yu H, Guo Z, Liu L
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9980565
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9980565
Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Wang Y, Wang J, Yang J, Kang J, Xue F, Chang S, Ji H, Zang H, Zhou X, Wang G, Fan W, Yan X, Guo J, Ren X, Tian J
Oxidative medicine and cellular longevity 2021;2021:8889408
Oxidative medicine and cellular longevity 2021;2021:8889408
Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
Zhao W, Wu Y, Ye F, Huang S, Chen H, Zhou R, Jiang W
BioMed research international 2021;2021:8870674
BioMed research international 2021;2021:8870674
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Ma N, Yang X, Qi C, Yu Q, Zhu C, Ren H
Oxidative medicine and cellular longevity 2021;2021:8847844
Oxidative medicine and cellular longevity 2021;2021:8847844
Wenxin Granules Regulate Endoplasmic Reticulum Stress Unfolded Protein Response and Improve Ventricular Remodeling on Rats with Myocardial Infarction.
Liu K, Lv M, Ji X, Lou L, Nie B, Zhao J, Wu A, Zhao M
Evidence-based complementary and alternative medicine : eCAM 2021;2021:7375549
Evidence-based complementary and alternative medicine : eCAM 2021;2021:7375549
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Liu J, Wu Q, Yang T, Yang F, Guo T, Zhou Y, Han S, Luo Y, Guo T, Luo F, Lin Q
Oxidative medicine and cellular longevity 2021;2021:2637577
Oxidative medicine and cellular longevity 2021;2021:2637577
Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways.
Zhang H, Zhao J, Lu Q, Sun B, Liu X, Yang C, Li S, Li L, Yi S, Yang Z, Xu J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Evidence-based complementary and alternative medicine : eCAM 2021;2021:1718709
Qingda granule exerts neuroprotective effects against ischemia/reperfusion-induced cerebral injury via lncRNA GAS5/miR-137 signaling pathway.
Zhang L, Cai Q, Lin S, Chen B, Jia B, Ye R, Weygant N, Chu J, Peng J
International journal of medical sciences 2021;18(7):1687-1698
International journal of medical sciences 2021;18(7):1687-1698
Hyperbaric Oxygen Therapy Attenuates Burn-Induced Denervated Muscle Atrophy.
Chen CA, Huang YC, Lo JJ, Wang SH, Huang SH, Wu SH
International journal of medical sciences 2021;18(16):3821-3830
International journal of medical sciences 2021;18(16):3821-3830
Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study.
Zhang P, Yu B, Jin X, Zhao T, Ye F, Liu X, Li P, Zheng X, Chen W, Li Q
International journal of nanomedicine 2021;16:4661-4674
International journal of nanomedicine 2021;16:4661-4674
Inhibition of mu-opioid receptor suppresses proliferation of hepatocellular carcinoma cells via CD147-p53-MAPK cascade signaling pathway.
Zhang JJ, Song CG, Dai JM, Zhang XQ, Lin P, Li L, Yang XM, Chen ZN
American journal of translational research 2021;13(5):3967-3986
American journal of translational research 2021;13(5):3967-3986
The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.
Wang H, Ren R, Yang Z, Cai J, Du S, Shen X
Journal of Cancer 2021;12(5):1406-1420
Journal of Cancer 2021;12(5):1406-1420
Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells.
Zou N, Zhang X, Li S, Li Y, Zhao Y, Yang X, Zhu S
Journal of Cancer 2021;12(16):5013-5024
Journal of Cancer 2021;12(16):5013-5024
MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects.
Deng X, Zuo M, Pei Z, Xie Y, Yang Z, Zhang Z, Jiang M, Kuang D
Journal of Cancer 2021;12(15):4710-4721
Journal of Cancer 2021;12(15):4710-4721
Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells.
Jin Y, Zhou Q, Geng J, Meng Q, Wei Z, Ding M, Zhou J, Zeng Y, Cao W, Liu F, Yu Y
Frontiers in pharmacology 2021;12:792360
Frontiers in pharmacology 2021;12:792360
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Wang D, Song M, Shen LF, Han L, Zhu P, Jia X, Shang GK, Cao Y, Zhang W, Zhong M, Wang ZH
Frontiers in physiology 2021;12:786895
Frontiers in physiology 2021;12:786895
Kaempferol Ameliorates the Inhibitory Activity of Dexamethasone in the Osteogenesis of MC3T3-E1 Cells by JNK and p38-MAPK Pathways.
Xie B, Zeng Z, Liao S, Zhou C, Wu L, Xu D
Frontiers in pharmacology 2021;12:739326
Frontiers in pharmacology 2021;12:739326
miR-25 Regulates Gastric Cancer Cell Growth and Apoptosis by Targeting EGR2.
Yang L, Li L, Chang P, Wei M, Chen J, Zhu C, Jia J
Frontiers in genetics 2021;12:690196
Frontiers in genetics 2021;12:690196
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Peng HH, Wang JN, Xiao LF, Yan M, Chen SP, Wang L, Yang K
Frontiers in genetics 2021;12:651647
Frontiers in genetics 2021;12:651647
Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I.
Jiang L, Yin X, Chen YH, Chen Y, Jiang W, Zheng H, Huang FQ, Liu B, Zhou W, Qi LW, Li J
Theranostics 2021;11(4):1703-1720
Theranostics 2021;11(4):1703-1720
Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure.
Yang X, Yu X, Zhao Z, He Y, Zhang J, Su X, Sun N, Fan Z
Journal of Zhejiang University. Science. B 2021 Sept 15;22(9):746-756
Journal of Zhejiang University. Science. B 2021 Sept 15;22(9):746-756
Hydroxychloroquine alleviates the neurotoxicity induced by anti-ribosomal P antibodies.
Zhao X, Yang P
Journal of neuroimmunology 2021 Sep 15;358:577648
Journal of neuroimmunology 2021 Sep 15;358:577648
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
Li L, Cheng SQ, Guo W, Cai ZY, Sun YQ, Huang XX, Yang J, Ji J, Chen YY, Dong YF, Cheng H, Sun XL
Journal of cellular and molecular medicine 2021 Oct;25(20):9753-9766
Journal of cellular and molecular medicine 2021 Oct;25(20):9753-9766
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Zeng L, Zou Q, Huang P, Xiong L, Cheng Y, Chen Q, Li Y, He H, Yi W, Wei W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994
EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway.
Han J, Wang L, Lv H, Liu J, Dong Y, Shi L, Ji Q
Archives of biochemistry and biophysics 2021 Oct 30;711:109024
Archives of biochemistry and biophysics 2021 Oct 30;711:109024
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Yang J, Zhang M, Yang D, Ma Y, Tang Y, Xing M, Li L, Chen L, Jin Y, Ma C
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Feng X, Cao A, Qin T, Zhang Q, Fan S, Wang B, Song B, Yu X, Li L
Oncology reports 2021 Nov;46(5)
Oncology reports 2021 Nov;46(5)
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90.
Li L, Yang M, Li C, Liu Y
Naunyn-Schmiedeberg's archives of pharmacology 2021 Nov;394(11):2223-2232
Naunyn-Schmiedeberg's archives of pharmacology 2021 Nov;394(11):2223-2232
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Chen W, Zhao S, Yu W, Rao T, Ruan Y, Zhu S, Xia Y, Song H, Cheng F
Journal of cellular and molecular medicine 2021 Nov;25(22):10684-10697
Journal of cellular and molecular medicine 2021 Nov;25(22):10684-10697
Metformin attenuates H(2)O(2)-induced osteoblast apoptosis by regulating SIRT3 via the PI3K/AKT pathway.
Yang K, Pei L, Zhou S, Tao L, Zhu Y
Experimental and therapeutic medicine 2021 Nov;22(5):1316
Experimental and therapeutic medicine 2021 Nov;22(5):1316
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Pan X, Zhou Y, Duan X, Cui J, Liu J, Song X, Ma W, Zhang W, Liu Y, Fan Y
Research in veterinary science 2021 Nov;140:47-55
Research in veterinary science 2021 Nov;140:47-55
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.
Wu X, Liu L, Zheng Q, Hao H, Ye H, Li P, Yang H
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3553-3566
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3553-3566
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer.
Zheng S, Wang J, Ding N, Chen W, Chen H, Xue M, Chen F, Ni J, Wang Z, Lin Z, Jiang H, Liu X, Wang L
Journal of nanobiotechnology 2021 Nov 21;19(1):381
Journal of nanobiotechnology 2021 Nov 21;19(1):381
The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Wang B, Zhang M, Guo J, Liu Z, Zhou R, Guo F, Li K, Mu Y
International journal of molecular sciences 2021 Nov 11;22(22)
International journal of molecular sciences 2021 Nov 11;22(22)
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
Pang JL, Huang FH, Zhang YH, Wu Y, Ge XM, Li S, Li X
Toxicology and applied pharmacology 2021 Nov 1;430:115726
Toxicology and applied pharmacology 2021 Nov 1;430:115726
Methylation gene KCNC1 is associated with overall survival in patients with seminoma.
Chen S, Xiao L, Peng H, Wang Z, Xie J
Oncology reports 2021 May;45(5)
Oncology reports 2021 May;45(5)
Toxicological and physiological effects of successive exposure to ochratoxin A at food regulatory limits.
Wei W, Liu C, Ke P, Chen X, Zhou T, Xu J, Zhou Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 May;151:112128
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 May;151:112128
Dual-Targeting Antiproliferation Hybrids Derived from 1-Deoxynojirimycin and Kaempferol Induce MCF-7 Cell Apoptosis through the Mitochondria-Mediated Pathway.
Zhang R, Zhang Y, Xin X, Huang G, Zhang N, Zeng Q, Tang L, Attaribo T, Lee KS, Jin BR, Gui Z
Journal of natural products 2021 May 28;84(5):1534-1543
Journal of natural products 2021 May 28;84(5):1534-1543
Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Li SY, Wang CY, Zhao JJ, Long CY, Xiao YX, Tang XB, Yuan ZW, Bai YZ
Experimental cell research 2021 May 15;402(2):112574
Experimental cell research 2021 May 15;402(2):112574
Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis.
Liu S, Xu A, Gao Y, Xie Y, Liu Z, Sun M, Mao H, Wang X
Journal of nanobiotechnology 2021 Mar 25;19(1):85
Journal of nanobiotechnology 2021 Mar 25;19(1):85
Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.
Wang F, Younis M, Luo Y, Zhang L, Yuan L
International immunopharmacology 2021 Jun;95:107532
International immunopharmacology 2021 Jun;95:107532
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
Liu S, Hu J, Shi C, Sun L, Yan W, Song Y
Journal of cellular and molecular medicine 2021 Jun;25(12):5511-5524
Journal of cellular and molecular medicine 2021 Jun;25(12):5511-5524
O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress.
Liu Y, Xu B, Hu Y, Liu P, Lian S, Lv H, Yang Y, Ji H, Yang H, Liu J, Yao R, Li S
Cryobiology 2021 Jun;100:125-132
Cryobiology 2021 Jun;100:125-132
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Li Y, Zhu X, Yang M, Wang Y, Li J, Fang J, Guo W, Ma S, Guan F
Molecular carcinogenesis 2021 Jul;60(7):440-454
Molecular carcinogenesis 2021 Jul;60(7):440-454
BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-dependent manner to regulate autophagy and inflammation.
Sun X, Zhu H, Cao R, Zhang J, Wang X
Pharmacological research 2021 Jul;169:105611
Pharmacological research 2021 Jul;169:105611
HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation.
Shao Y, Zhu F, Zhu S, Bai L
The international journal of biochemistry & cell biology 2021 Jul;136:106000
The international journal of biochemistry & cell biology 2021 Jul;136:106000
G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer.
Zhao J, Fu X, Chen H, Min L, Sun J, Yin J, Guo J, Li H, Tang Z, Ruan Y, Wang X, Sun Y, Huang L
British journal of cancer 2021 Jan;124(2):425-436
British journal of cancer 2021 Jan;124(2):425-436
Histone deacetylase 10 exerts anti-tumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
Zhu J, Han S
IUBMB life 2021 Jan 22;
IUBMB life 2021 Jan 22;
iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis.
Yagudin T, Zhao Y, Gao H, Zhang Y, Yang Y, Zhang X, Ma W, Daba TM, Ishmetov V, Kang K, Yang B, Pan Z
Acta biochimica et biophysica Sinica 2021 Jan 12;53(1):102-111
Acta biochimica et biophysica Sinica 2021 Jan 12;53(1):102-111
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
Xu Y, Yu J, Ma C, Gong Z, Wu X, Deng G
Molecular immunology 2021 Feb;130:85-95
Molecular immunology 2021 Feb;130:85-95
Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo.
Hao EJ, Li GX, Liang YR, Xie MS, Wang DC, Jiang XH, Cheng JY, Shi ZX, Wang Y, Guo HM
Journal of medicinal chemistry 2021 Feb 25;64(4):2077-2109
Journal of medicinal chemistry 2021 Feb 25;64(4):2077-2109
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393
Journal of bone oncology 2021 Dec;31:100393
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Hou JR, Wang YH, Zhong YN, Che TT, Hu Y, Bao J, Meng N
Marine drugs 2021 Dec 18;19(12)
Marine drugs 2021 Dec 18;19(12)
Structural analysis of Panax ginseng glycoproteins and its anti-oligoasthenozoospermia effect in vivo.
Shan M, Zhang X, Fang X, Tian J, Song L, Chen Y, Qiu Z, Zhu D, Luo H, Wang Z
International journal of biological macromolecules 2021 Dec 15;193(Pt A):778-788
International journal of biological macromolecules 2021 Dec 15;193(Pt A):778-788
Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
Jiang L, Wang M, Sun R, Lin Z, Liu R, Cai H, Tang Z, Zhang R
Cell biology international 2021 Aug;45(8):1666-1675
Cell biology international 2021 Aug;45(8):1666-1675
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Cheng Y, Hu Y, Wang H, Zhao Z, Jiang X, Zhang Y, Zhang J, Tong Y, Qiu X
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway.
Bian Q, Chen B, Weng B, Chu D, Tang X, Yan S, Yin Y, Ran M
International journal of molecular sciences 2021 Aug 30;22(17)
International journal of molecular sciences 2021 Aug 30;22(17)
Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.
Yan D, Li X, Yang Q, Huang Q, Yao L, Zhang P, Sun W, Lin S, Dou QP, Liu J, Chen X
Cell death discovery 2021 Aug 11;7(1):211
Cell death discovery 2021 Aug 11;7(1):211
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Chen Y, Liang J, Liang X, Chen J, Wang Y, Cao J, Sun C, Ye J, Chen Q
Food science & nutrition 2021 Apr;9(4):1860-1869
Food science & nutrition 2021 Apr;9(4):1860-1869
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
Zhu J, Han S
IUBMB life 2021 Apr;73(4):690-704
IUBMB life 2021 Apr;73(4):690-704
miR-101-3p sensitizes lung adenocarcinoma cells to irradiation via targeting BIRC5.
Meng X, Sun Y, Liu S, Mu Y
Oncology letters 2021 Apr;21(4):282
Oncology letters 2021 Apr;21(4):282
Dracomolphin A-E, new lignans from Dracocephalum moldavica.
Zhang H, Wang S, Liu Q, Zheng H, Liu X, Wang X, Shen T, Ren D
Fitoterapia 2021 Apr;150:104841
Fitoterapia 2021 Apr;150:104841
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Chen J, Zhang W, Pan C, Fan J, Zhong X, Tang S
Life sciences 2021 Apr 15;271:119185
Life sciences 2021 Apr 15;271:119185
Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo.
Wang CH, Yang JM, Guo YB, Shen J, Pei XH
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6823520
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6823520
AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress.
Xiong S, Han Y, Gao P, Zhao H, Jiang N, Sun L
Oxidative medicine and cellular longevity 2020;2020:6104375
Oxidative medicine and cellular longevity 2020;2020:6104375
Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression.
Zou Y, Li R, Kuang D, Zuo M, Li W, Tong W, Jiang L, Zhou M, Chen Y, Gong W, Liu L, Tou F
BioMed research international 2020;2020:5846938
BioMed research international 2020;2020:5846938
Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway.
Li L, Peng X, Guo L, Zhao Y, Cheng Q
International journal of clinical and experimental pathology 2020;13(5):964-971
International journal of clinical and experimental pathology 2020;13(5):964-971
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Feng AL, Han X, Meng X, Chen Z, Li Q, Shu W, Dai H, Zhu J, Yang Z
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Jiang N, Zhao H, Han Y, Li L, Xiong S, Zeng L, Xiao Y, Wei L, Xiong X, Gao P, Yang M, Liu Y, Sun L
Cell proliferation 2020 Nov;53(11):e12909
Cell proliferation 2020 Nov;53(11):e12909
Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibiting VEGF production.
Yang Z, Guo J, Cui K, Du Y, Zhao H, Zhu L, Weng L, Tang W, Guo J, Zhang T, Shi X, Zong H, Jin S, Ma W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110740
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110740
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Wang J, Liu X, Zheng H, Liu Q, Zhang H, Wang X, Shen T, Wang S, Ren D
Chemico-biological interactions 2020 Nov 1;331:109279
Chemico-biological interactions 2020 Nov 1;331:109279
Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents.
Li B, Zhu F, He F, Huang Q, Liu X, Wu T, Zhao T, Qiu Y, Wu Z, Xue Y, Fang M
Bioorganic chemistry 2020 Mar;96:103592
Bioorganic chemistry 2020 Mar;96:103592
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
Zhang J, Chen Y, Lin J, Jia R, An T, Dong T, Zhang Y, Yang X
DNA and cell biology 2020 Mar;39(3):355-367
DNA and cell biology 2020 Mar;39(3):355-367
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Zheng Y, Nie P, Xu S
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway.
Ji J, Wu L, Feng J, Mo W, Wu J, Yu Q, Li S, Zhang J, Dai W, Xu X, Mao Y, Xu S, Chen K, Li J, Guo C
International immunopharmacology 2020 Jul;84:106529
International immunopharmacology 2020 Jul;84:106529
Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury.
Hu X, Li R, Wu Y, Li Y, Zhong X, Zhang G, Kang Y, Liu S, Xie L, Ye J, Xiao J
Journal of cellular and molecular medicine 2020 Jul;24(14):8166-8178
Journal of cellular and molecular medicine 2020 Jul;24(14):8166-8178
Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.
Niu Q, Sun W, Chen Q, Long Y, Cao W, Wen S, Li A, Dong F, Shi H
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 20;26:e923049
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 20;26:e923049
Epigenetic upregulation of HOXC10 in non-small lung cancer cells.
Li M, Alsager JS, Wang Z, Cheng L, Shan B
Aging 2020 Jul 19;12(17):16921-16935
Aging 2020 Jul 19;12(17):16921-16935
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665
BMC cancer 2020 Jul 16;20(1):665
Anti-CD19 mAb-conjugated human serum albumin nanoparticles effectively deliver doxorubicin to B-lymphoblastic leukemia cells.
Pan H, Li S, Li M, Tao Q, Jia J, Li W, Wang L, Guo Z, Ma K, Liu Y, Cui C
Die Pharmazie 2020 Jul 1;75(7):318-323
Die Pharmazie 2020 Jul 1;75(7):318-323
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Wu Y, Zhao Y, He X, He Z, Wang T, Wan L, Chen L, Yan N
Molecular medicine reports 2020 Jan;21(1):249-257
Molecular medicine reports 2020 Jan;21(1):249-257
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, Yu Q, Kong R, Li S, Zhang J, Ji J, Wu J, Mo W, Xu X, Guo C
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway.
Yang J, Zhu XJ, Jin MZ, Cao ZW, Ren YY, Gu ZW
Chemico-biological interactions 2020 Jan 25;316:108934
Chemico-biological interactions 2020 Jan 25;316:108934
Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma.
Ding XY, Hu HY, Huang KN, Wei RQ, Min J, Qi C, Tang H, Qin X
Cancer science 2020 Feb;111(2):489-501
Cancer science 2020 Feb;111(2):489-501
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Chen X, Ji S, Si J, Zhang X, Wang X, Guo Y, Zou X
Molecular medicine reports 2020 Dec;22(6):5243-5250
Molecular medicine reports 2020 Dec;22(6):5243-5250
NFIB functions as an oncogene in estrogen receptor-positive breast cancer and is regulated by miR-205-5p.
Chen H, Yu C, Shen L, Wu Y, Wu D, Wang Z, Song G, Chen L, Hong Y
Pathology, research and practice 2020 Dec;216(12):153236
Pathology, research and practice 2020 Dec;216(12):153236
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Sha L, Ma D, Chen C
Aging 2020 Dec 13;12(23):23598-23608
Aging 2020 Dec 13;12(23):23598-23608
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, Wang Y, Yang J, Yan M, Lv G, Chen S
International journal of biological macromolecules 2020 Apr 15;149:320-330
International journal of biological macromolecules 2020 Apr 15;149:320-330
Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury.
Zilberman-Itskovich S, Abu-Hamad R, Zarura R, Sova M, Hachmo Y, Stark M, Neuman S, Slavin S, Efrati S
PloS one 2019;14(9):e0222354
PloS one 2019;14(9):e0222354
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Ma Y, Guan L, Han Y, Zhou Y, Li X, Liu Y, Zhang X, Zhang W, Li X, Wang S, Lu W
Cancer management and research 2019;11:5799-5811
Cancer management and research 2019;11:5799-5811
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Li F, Wu JT, Wang PF, Qu LZ
Experimental and therapeutic medicine 2019 Oct;18(4):3037-3045
Experimental and therapeutic medicine 2019 Oct;18(4):3037-3045
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang YY, Yang H, Li S
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.
Chen B, Yang L, Chen J, Chen Y, Zhang L, Wang L, Li X, Li Y, Yu H
Brain research bulletin 2019 Mar;146:124-135
Brain research bulletin 2019 Mar;146:124-135
Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice.
Liu P, Yao R, Shi H, Liu Y, Lian S, Yang Y, Yang H, Li S
International journal of molecular sciences 2019 Mar 23;20(6)
International journal of molecular sciences 2019 Mar 23;20(6)
Tamibarotene Improves Hippocampus Injury Induced by Focal Cerebral Ischemia-Reperfusion via Modulating PI3K/Akt Pathway in Rats.
Tian X, An R, Luo Y, Li M, Xu L, Dong Z
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jul;28(7):1832-1840
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jul;28(7):1832-1840
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
Song T, Ma K, Zhao C, Yang J, Liu J
Oncology letters 2019 Aug;18(2):2043-2049
Oncology letters 2019 Aug;18(2):2043-2049
Magnesium isoglycyrrhizinate ameliorates fructose-induced podocyte apoptosis through downregulation of miR-193a to increase WT1.
Li TS, Chen L, Wang SC, Yang YZ, Xu HJ, Gu HM, Zhao XJ, Dong P, Pan Y, Shang ZQ, Zhang XQ, Kong LD
Biochemical pharmacology 2019 Aug;166:139-152
Biochemical pharmacology 2019 Aug;166:139-152
The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway.
Ou B, Tao W, Yang S, Feng J, Wang J, Yang T, Wu H, Huang Y, Tan L, Huang W, Feng Z, Mei Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7290170
Beraprost sodium preconditioning prevents inflammation, apoptosis, and autophagy during hepatic ischemia-reperfusion injury in mice via the P38 and JNK pathways.
Deng J, Feng J, Liu T, Lu X, Wang W, Liu N, Lv Y, Liu Q, Guo C, Zhou Y
Drug design, development and therapy 2018;12:4067-4082
Drug design, development and therapy 2018;12:4067-4082
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Yin Y, Xu M, Gao J, Li M
Pathology, research and practice 2018 Sep;214(9):1381-1387
Pathology, research and practice 2018 Sep;214(9):1381-1387
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Shi X, Yang L, Xie J, Zhao Y, Cong J, Li Z, Li H, Cheng X, Fan J
Molecular medicine reports 2018 Sep;18(3):3382-3388
Molecular medicine reports 2018 Sep;18(3):3382-3388
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
Yao R, Yang Y, Lian S, Shi H, Liu P, Liu Y, Yang H, Li S
International journal of molecular sciences 2018 Sep 18;19(9)
International journal of molecular sciences 2018 Sep 18;19(9)
LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation.
Zeng K, Chen X, Hu X, Liu X, Xu T, Sun H, Pan Y, He B, Wang S
Oncogene 2018 Oct;37(41):5534-5551
Oncogene 2018 Oct;37(41):5534-5551
DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells.
Sun N, Zhang J, Zhang C, Zhao B, Jiao A
Oncology letters 2018 Nov;16(5):5799-5806
Oncology letters 2018 Nov;16(5):5799-5806
UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells.
Yue X, Li M, Chen D, Xu Z, Sun S
Experimental and therapeutic medicine 2018 Nov;16(5):3921-3928
Experimental and therapeutic medicine 2018 Nov;16(5):3921-3928
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway.
Li M, Tian X, An R, Yang M, Zhang Q, Xiang F, Liu H, Wang Y, Xu L, Dong Z
Neurochemical research 2018 Jun;43(6):1283-1296
Neurochemical research 2018 Jun;43(6):1283-1296
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Feng J, Niu P, Chen K, Wu L, Liu T, Xu S, Li J, Li S, Wang W, Lu X, Yu Q, Liu N, Xu L, Wang F, Dai W, Xia Y, Fan X, Guo C
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, Xiong Y, Wang Y, Ye Q
Molecular medicine reports 2018 Jul;18(1):815-826
Molecular medicine reports 2018 Jul;18(1):815-826
14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells.
Lu K, Rui G, Liu F, Yang L, Deng X, Shi S, Li Q
Oncology letters 2018 Jan;15(1):338-346
Oncology letters 2018 Jan;15(1):338-346
A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.
Wang L, Qu G, Gao Y, Su L, Ye Q, Jiang F, Zhao B, Miao J
RSC advances 2018 Jan 2;8(2):792-804
RSC advances 2018 Jan 2;8(2):792-804
Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.
Zhang P, Hua L, Hou H, Du X, He Z, Liu M, Hu X, Yan N
International journal of molecular medicine 2018 Dec;42(6):3344-3354
International journal of molecular medicine 2018 Dec;42(6):3344-3354
Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke.
Liu Z, Xie J, Lin K, Qi L
Experimental and therapeutic medicine 2018 Dec;16(6):4423-4428
Experimental and therapeutic medicine 2018 Dec;16(6):4423-4428
Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage.
Zhang JX, Wang R, Xi J, Shen L, Zhu AY, Qi Q, Wang QY, Zhang LJ, Wang FC, Lü HZ, Hu JG
International journal of molecular medicine 2017 Mar;39(3):603-612
International journal of molecular medicine 2017 Mar;39(3):603-612
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Yang F, Shi L, Liang T, Ji L, Zhang G, Shen Y, Zhu F, Xu L
Biochemical and biophysical research communications 2017 Mar 25;485(1):54-61
Biochemical and biophysical research communications 2017 Mar 25;485(1):54-61
Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells.
Li B, Hou D, Guo H, Zhou H, Zhang S, Xu X, Liu Q, Zhang X, Zou Y, Gong Y, Shao C
Scientific reports 2017 Mar 16;7(1):208
Scientific reports 2017 Mar 16;7(1):208
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.
Zhao XS, Wu Q, Peng J, Pan LH, Ren Z, Liu HT, Jiang ZS, Wang GX, Tang ZH, Liu LS
Molecular medicine reports 2017 Feb;15(2):712-718
Molecular medicine reports 2017 Feb;15(2):712-718
Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis.
Wu L, Wang C, Li J, Li S, Feng J, Liu T, Xu S, Wang W, Lu X, Chen K, Xia Y, Fan X, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1137-1146
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:1137-1146
Effects of dimethyl carbonate-induced autophagic activation on follicular development in the mouse ovary.
Tang Z, Zhang Z, Tang Y, Qi L, Yang F, Wang Z
Experimental and therapeutic medicine 2017 Dec;14(6):5981-5989
Experimental and therapeutic medicine 2017 Dec;14(6):5981-5989
Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes.
Xu X, Li D, Li X, Shi Q, Ju X
BMC immunology 2017 Dec 19;18(1):51
BMC immunology 2017 Dec 19;18(1):51
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N, Zhang J
International journal of endocrinology 2016;2016:4513051
International journal of endocrinology 2016;2016:4513051
Hsp70 suppresses apoptosis of BRL cells by regulating the expression of Bcl-2, cytochrome C, and caspase 8/3.
Kong F, Wang H, Guo J, Peng M, Ji H, Yang H, Liu B, Wang J, Zhang X, Li S
In vitro cellular & developmental biology. Animal 2016 May;52(5):568-75
In vitro cellular & developmental biology. Animal 2016 May;52(5):568-75
Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition.
Luo J, Wu N, Jiang B, Wang L, Wang S, Li X, Wang B, Wang C, Shi D
Marine drugs 2015 Jul 17;13(7):4452-69
Marine drugs 2015 Jul 17;13(7):4452-69
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- Main image
- Experimental details
- human testis tissue were subjected to SDS PAGE followed by western blot with 60267-1-Ig(BAX antibody) at dilution of 1:1000
- Sample type
- tissue
