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Learn21634-1-AP
antibody from Proteintech Group
Targeting: SMARCA4
BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 21634-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21634-1-AP, RRID:AB_10858784
- Product name
- SMARCA4/BRG1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SMARCA4/BRG1 antibody (Cat. #21634-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.
Brahma-Related Gene-1 (BRG1) promotes the malignant phenotype of glioblastoma cells.
SMARCB1-deficient sinonasal carcinoma: a case report and literature review.
ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.
RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells.
The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells.
BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1.
HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.
miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis.
lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression.
Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells.
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.
BRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo.
Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development.
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.
Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing.
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling.
Hu S, Peng L, Xu C, Wang Z, Song A, Chen FX
Molecular cell 2021 Nov 4;81(21):4425-4439.e6
Molecular cell 2021 Nov 4;81(21):4425-4439.e6
Brahma-Related Gene-1 (BRG1) promotes the malignant phenotype of glioblastoma cells.
Wang Y, Yang CH, Schultz AP, Sims MM, Miller DD, Pfeffer LM
Journal of cellular and molecular medicine 2021 Mar;25(6):2956-2966
Journal of cellular and molecular medicine 2021 Mar;25(6):2956-2966
SMARCB1-deficient sinonasal carcinoma: a case report and literature review.
Yanagawa N, Suzuki M, Sugimoto R, Osakabe M, Uesugi N, Shiga K, Sugai T
Journal of surgical case reports 2021 Apr;2021(4):rjab161
Journal of surgical case reports 2021 Apr;2021(4):rjab161
ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.
Sun X, Yu W, Li L, Sun Y
Frontiers in cell and developmental biology 2020;8:553
Frontiers in cell and developmental biology 2020;8:553
RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells.
Yan X, Han D, Chen Z, Han C, Dong W, Han L, Zou L, Zhang J, Liu Y, Chai J
Cancer cell international 2020;20:505
Cancer cell international 2020;20:505
The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells.
Tu J, Liu X, Jia H, Reilly J, Yu S, Cai C, Liu F, Lv Y, Huang Y, Lu Z, Han S, Jiang T, Shu X, Wu X, Tang Z, Lu Q, Liu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):11997-12008
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Sep;34(9):11997-12008
BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1.
Wu S, Ge Y, Li X, Yang Y, Zhou H, Lin K, Zhang Z, Zhao Y
PLoS genetics 2020 Jun;16(6):e1008799
PLoS genetics 2020 Jun;16(6):e1008799
HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.
Zhu X, Lan B, Yi X, He C, Dang L, Zhou X, Lu Y, Sun Y, Liu Z, Bai X, Zhang K, Li B, Li MJ, Chen Y, Zhang L
Nucleic acids research 2020 Jul 9;48(12):6563-6582
Nucleic acids research 2020 Jul 9;48(12):6563-6582
miR-296-5p suppresses stem cell potency of hepatocellular carcinoma cells via regulating Brg1/Sall4 axis.
Shi DM, Shi XL, Xing KL, Zhou HX, Lu LL, Wu WZ
Cellular signalling 2020 Aug;72:109650
Cellular signalling 2020 Aug;72:109650
lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression.
Huang M, Wang H, Hu X, Cao X
Oncoimmunology 2019;8(1):e1518628
Oncoimmunology 2019;8(1):e1518628
Chromatin Remodeling Factor BRG1 Regulates Stemness and Chemosensitivity of Glioma Initiating Cells.
Ganguly D, Sims M, Cai C, Fan M, Pfeffer LM
Stem cells (Dayton, Ohio) 2018 Dec;36(12):1804-1815
Stem cells (Dayton, Ohio) 2018 Dec;36(12):1804-1815
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Tibshirani M, Zhao B, Gentil BJ, Minotti S, Marques C, Keith J, Rogaeva E, Zinman L, Rouaux C, Robertson J, Durham HD
Human molecular genetics 2017 Nov 1;26(21):4142-4152
Human molecular genetics 2017 Nov 1;26(21):4142-4152
The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes.
de Castro RO, Previato L, Goitea V, Felberg A, Guiraldelli MF, Filiberti A, Pezza RJ
The Journal of biological chemistry 2017 May 19;292(20):8459-8471
The Journal of biological chemistry 2017 May 19;292(20):8459-8471
BRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo.
Marquez-Vilendrer SB, Rai SK, Gramling SJ, Lu L, Reisman DN
Oncoscience 2016;3(11-12):337-350
Oncoscience 2016;3(11-12):337-350
Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development.
Marquez-Vilendrer SB, Rai SK, Gramling SJ, Lu L, Reisman DN
Oncoscience 2016;3(11-12):322-336
Oncoscience 2016;3(11-12):322-336
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.
Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z
Nature communications 2016 Dec 1;7:13608
Nature communications 2016 Dec 1;7:13608
Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing.
Araujo LH, Timmers C, Bell EH, Shilo K, Lammers PE, Zhao W, Natarajan TG, Miller CJ, Zhang J, Yilmaz AS, Liu T, Coombes K, Amann J, Carbone DP
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Jun 10;33(17):1966-73
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Jun 10;33(17):1966-73
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling.
Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z
Cell stem cell 2015 Apr 2;16(4):413-25
Cell stem cell 2015 Apr 2;16(4):413-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 21634-1-AP(SMARCA4 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SMARCA4 antibody 21634-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 21634-1-AP(SMARCA4 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 21634-1-AP(SMARCA4 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
