DCABH-4567

antibody from Creative Diagnostics

Targeting: DOK1 p62dok

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-4567

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-4567, RRID:AB_2478330

Product name

Rabbit Anti-Human DOK1 polyclonal antibody

Antibody type

Polyclonal

Description

DOK-1 (P62dok, Docking protein 1) is believed to be a mainly cytoplasmic adaptor protein which down-regulates mitogen-activated protein kinase activation, inhibits cell proliferation and transformation, and promotes cell spreading and cell migration. DOK-1 is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, DOK-1 forms a complex with ras GTPase-activating protein. Phosphorylation on tyrosine residues by the insulin receptor kinase results in the negative regulation of the insulin signaling pathway. DOK-1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.