ABIN362351

antibody from antibodies-online

Targeting: DOK1 p62dok

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN362351

Provider

antibodies-online

Product name

anti-Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) (pTyr398) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pTyr398 (E-G-Y (p) -E-L) derived from Human p62Dok. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pTyr398

Isotype

IgG

Vial size

50 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation.

Simoncic PD, Bourdeau A, Lee-Loy A, Rohrschneider LR, Tremblay ML, Stanley ER, McGlade CJ
Molecular and cellular biology 2006 Jun;26(11):4149-60

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Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

Wick MJ, Dong LQ, Hu D, Langlais P, Liu F
The Journal of biological chemistry 2001 Nov 16;276(46):42843-50