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- Antibody Data
- Antigen structure
- References [396]
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- Product number
- 16443-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16443-1-AP, RRID:AB_10603369
- Product name
- ERK1/2 antibody
- Antibody type
- Polyclonal
- Description
- ERK1/2 antibody (Cat. #16443-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation.
Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status.
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation.
Zinc alleviates thermal stress-induced damage to the integrity and barrier function of cultured chicken embryonic primary jejunal epithelial cells via the MAPK and PI3K/AKT/mTOR signaling pathways.
Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction.
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Shenqu xiaoshi oral solution enhances digestive function and stabilizes the gastrointestinal microbiota of juvenile rats with infantile anorexia.
KBTBD2 promotes proliferation and migration of gastric cancer via activating EGFR signaling pathway.
The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway.
Farrerol suppresses osteoclast differentiation and postmenopausal osteoporosis by inhibiting the nuclear factor kappa B signaling pathway.
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway.
Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK signaling pathway.
Exploring the Potential Mechanisms of Guanxinshutong Capsules in Treating Pathological Cardiac Hypertrophy based on Network Pharmacology, Computer-Aided Drug Design, and Animal Experiments.
Upregulated desmin/integrin β1/MAPK axis promotes elastic cartilage regeneration with increased ECM mechanical strength.
Tumor-derived Immunoglobulin-like transcript 4 facilitates angiogenesis of colorectal cancer.
Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study.
KRAS mutations upregulate Runx1 to promote occurrence of head and neck squamous cell carcinoma.
LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway.
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation.
Konjac glucomannan attenuate high-fat diet-fed obesity through enhancing β-adrenergic-mediated thermogenesis in inguinal white adipose tissue in mice.
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.
Nucleophilic covalent ligand discovery for the cysteine redoxome.
Xiaozheng pill exerts an anti-mammary hyperplasia effect through Raf/ERK/ELK and HIF-1α/bFGF pathways.
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
Effective-compound combination of Bufei Yishen formula III combined with ER suppress airway mucus hypersecretion in COPD rats: via EGFR/MAPK signaling.
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
Extracts of Oldenlandia diffusa protects chondrocytes via inhibiting apoptosis and associated inflammatory response in osteoarthritis.
Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis.
Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway.
Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC.
TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor.
CRYAA and GJA8 promote visual development after whisker tactile deprivation.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway.
Norepinephrine/β(2)-Adrenergic Receptor Pathway Promotes the Cell Proliferation and Nerve Growth Factor Production in Triple-Negative Breast Cancer.
Administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors.
RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse.
TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice.
Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway.
Angiotensin-(1-7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways.
Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway.
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-α-TAK1 signaling pathway.
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders.
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury via inhibiting ferroptosis by the cAMP/PKA/CREB pathway.
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.
The Effect of Bone Morphogenetic Protein 2 or Extracellular Signal-Regulated Kinase 1 Silencing on Phosphorus Utilization and Related Parameters in Primary Broiler Osteoblasts.
Optimization of murine retinal mitochondrial injury model.
Morroniside Protects Human Granulosa Cells against H(2)O(2)-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways.
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
The Immune-Enhancing Properties of Hwanglyeonhaedok-Tang-Mediated Biosynthesized Gold Nanoparticles in Macrophages and Splenocytes.
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Chrysophanol-8-O-glucoside protects mice against acute liver injury by inhibiting autophagy in hepatic stellate cells and inflammatory response in liver-resident macrophages.
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation.
Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway.
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance.
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling.
Induction of COX-2 by feline calicivirus via activation of the MEK1-ERK1/2 pathway, and attenuation of feline lung inflammation and injury by MEK1 inhibitor AZD6244 (selumetinib).
The adenosine A(2A) receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.
CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5.
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.
CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases.
CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway.
Geniposide alleviates VEGF-induced angiogenesis by inhibiting VEGFR2/PKC/ERK1/2-mediated SphK1 translocation.
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
The role and mechanism of TLR4-siRNA in the impairment of learning and memory in young mice induced by isoflurane.
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.
GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis.
Acacetin attenuates Streptococcus suis virulence by simultaneously targeting suilysin and inflammation.
TSH-TSHR axis promotes tumor immune evasion.
Immune-enhancing effects of postbiotic produced by Bacillus velezensis Kh2-2 isolated from Korea Foods.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway.
WT1 suppresses follicle-stimulating hormone-induced progesterone secretion by regulating ERK1/2 pathway in chicken preovulatory granulosa cells.
Employing CRISPR-Cas9 to Generate CD133 Synthetic Lethal Melanoma Stem Cells.
Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice.
Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R.
Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways.
Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice.
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.
Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.
Kaempferol-Driven Inhibition of Listeriolysin O Pore Formation and Inflammation Suppresses Listeria monocytogenes Infection.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation.
Astrocytes Derived from Familial and Sporadic Alzheimer's Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau.
Dihydromyricetin Enhances Intestinal Antioxidant Capacity of Growing-Finishing Pigs by Activating ERK/Nrf2/HO-1 Signaling Pathway.
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
piR-121380 Is Involved in Cryo-Capacitation and Regulates Post-Thawed Boar Sperm Quality Through Phosphorylation of ERK2 via Targeting PTPN7.
m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.
Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways.
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.
The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation.
BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.
SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
Tetramethylpyrazine Alleviates Behavioral and Psychological Symptoms of Dementia Through Facilitating Hippocampal Synaptic Plasticity in Rats With Chronic Cerebral Hypoperfusion.
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.
MALAT-1 is Associated with the Doxorubicin Resistance in U-2OS Osteosarcoma Cells.
Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS.
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non-small-Cell Lung Cancer In Vivo and In Vitro.
Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.
XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression.
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.
A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo.
miRNA‑7515 suppresses pancreatic cancer cell proliferation, migration and invasion via downregulating IGF‑1 expression.
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
CCL2 is a critical mechano-responsive mediator in crosstalk between osteoblasts and bone mesenchymal stromal cells.
Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke.
Silencing ACTG1 Expression Induces Prostate Cancer Epithelial Mesenchymal Transition Through MAPK/ERK Signaling Pathway.
Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways.
Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction.
Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways.
Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma.
Effects of dietary icariin supplementation on the ovary development-related transcriptome of Chinese mitten crab (Eriocheir sinensis).
The RNA-Binding Protein CELF2 Inhibits Ovarian Cancer Progression by Stabilizing FAM198B.
miR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells.
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer.
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Adiponectin agonist treatment in diabetic pregnant rats.
NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice.
PDGF-BB promotes vascular smooth muscle cell migration by enhancing Pim-1 expression via inhibiting miR-214.
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
miR-483-3p Promotes IL-33 Production from Fibroblast-Like Synoviocytes by Regulating ERK Signaling in Rheumatoid Arthritis.
Qihuzha granule attenuated LPS-induced acute spleen injury in mice via Src/MAPK/Stat3 signal pathway.
Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression.
Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells.
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Sirtuin 3 deficiency aggravates angiotensin II-induced hypertensive cardiac injury by the impairment of lymphangiogenesis.
Paradoxical changes in mood-related behaviors on continuous social isolation after weaning.
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway.
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Synergistic effect of PAF inhibition and X-ray irradiation in non-small cell lung cancer cells.
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats.
Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.
Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression.
25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity.
GRHL2 Upregulation Predicts a Poor Prognosis and Promotes the Resistance of Serous Ovarian Cancer to Cisplatin.
FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway.
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus.
A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection.
Splenectomy enhances the Ly6C(low) phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level.
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens.
Functionalized graphene oxide against U251 glioma cells and its molecular mechanism.
TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling.
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling.
Silencing of DHX32 increases the proliferation of liver cancer cells.
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression.
Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity.
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Activation of BDNF/TrkB pathway promotes prostate cancer progression via induction of epithelial-mesenchymal transition and anoikis resistance.
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
AMPK decreases ERK1/2 activity and cancer cell sensitivity to nutrition deprivation by mediating a positive feedback loop involving eEF2K.
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
Programmed cell death protein 1 promotes hepatitis B virus transmission through the regulation of ERK1/2-mediated trophoblasts differentiation.
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response.
PP2A alleviates oxidized LDL-induced endothelial dysfunction by regulating LOX-1/ROS/MAPK axis.
Benzoylaconitine Inhibits Production of IL-6 and IL-8 via MAPK, Akt, NF-κB Signaling in IL-1β-Induced Human Synovial Cells.
Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells.
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis.
MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling.
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.
Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-κB or Nonactivating CREB/BDNF in Mouse Hippocampus.
Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.
Calcium-sensing receptor promotes tumor proliferation and migration in human intrahepatic cholangiocarcinoma by targeting ERK signaling pathway.
Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways.
Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis.
Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma.
Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.
Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract.
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK(½)/mTOR signaling pathways in oral squamous cell carcinomas.
CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
MicroRNA-125a-3p affects smooth muscle cell function in vascular stenosis.
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus.
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.
Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway.
Proteomic Profiles of the Early Mitochondrial Changes in APP/PS1 and ApoE4 Transgenic Mice Models of Alzheimer's Disease.
Elucidating dosage-effect relationship of different efficacy of rhubarb in constipation model rats by factor analysis.
Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells.
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects.
Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo.
Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury.
Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma.
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
Intermedin in Paraventricular Nucleus Attenuates Ang II-Induced Sympathoexcitation through the Inhibition of NADPH Oxidase-Dependent ROS Generation in Obese Rats with Hypertension.
Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation.
Treatment with MQA, a Derivative of Caffeoylquinic Acid, Provides Neuroprotective Effects against Cerebral Ischemia Through Suppression of the p38 Pathway and Oxidative Stress in Rats.
Carnosine improves diabetic retinopathy via the MAPK/ERK pathway.
GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway.
Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy.
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.
Axis of serotonin -pERK-YAP in liver regeneration.
2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis.
IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes.
Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma.
Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway.
Inhibition of transient receptor potential melastatin 8 alleviates airway inflammation and remodeling in a murine model of asthma with cold air stimulus.
Effects of gelling bath on the physical properties of alginate gel beads and the biological characteristics of entrapped HepG2 cells.
Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.
Down-regulation of GADD45A enhances chemosensitivity in melanoma.
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.
Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in hepatocellular carcinoma.
NF-κB and JNK mediated apoptosis and G(0)/G(1) arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis.
Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties.
Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis.
Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway.
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.
Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury.
Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer.
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease.
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells.
Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells.
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
AAED1 modulates proliferation and glycolysis in gastric cancer.
Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo.
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Interleukin-25 enhances the capacity of mesenchymal stem cells to induce intestinal epithelial cell regeneration.
Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions.
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism.
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Polyaniline promotes peripheral nerve regeneration by enhancement of the brain‑derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway.
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways.
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation.
Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Vascular protective effects of aqueous extracts of Tribulus terrestris on hypertensive endothelial injury.
Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway.
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway.
Hypoxia regulates ABCG2 activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells.
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Original Research: Atorvastatin prevents rat cardiomyocyte hypertrophy induced by parathyroid hormone 1-34 associated with the Ras-ERK signaling.
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
Charaterization and immunomodulatory activities of polysaccharide isolated from Pleurotus eryngii.
Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer.
HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells.
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
ELISA-PLA: A novel hybrid platform for the rapid, highly sensitive and specific quantification of proteins and post-translational modifications.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.
ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner.
The role of STIM1 in the Cr(vi)-induced [Ca(2+)](i) increase and cell injury in L-02 hepatocytes.
Paper-based microreactor array for rapid screening of cell signaling cascades.
HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma.
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
Famitinib enhances nasopharyngeal cancer cell radiosensitivity by attenuating radiation-induced phosphorylation of platelet-derived growth factor receptor and c-kit and inhibiting microvessel formation.
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.
Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion.
The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.
Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K/Akt, MEK/ERK and Wnt/β-catenin signaling pathways in B16F10 cells.
Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-кB signal pathway.
Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells.
Shu J, Yan S, Ju C, Chen L, Liang M, Wang C, Huang K
International journal of biological sciences 2024;20(5):1602-1616
International journal of biological sciences 2024;20(5):1602-1616
Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status.
Origüela V, Ferrer-Aguilar P, Gázquez A, Pérez-Cruz M, Gómez-Roig MD, Gómez-Llorente C, Larqué E
Placenta 2024 May;150:31-38
Placenta 2024 May;150:31-38
Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation.
Zhu Y, Ye X, Wu Y, Shen H, Cai Z, Xia F, Min W, Hou Y, Wang L, Wang X, Xiao Y, Yang P
Journal of medicinal chemistry 2024 May 9;67(9):7283-7300
Journal of medicinal chemistry 2024 May 9;67(9):7283-7300
Zinc alleviates thermal stress-induced damage to the integrity and barrier function of cultured chicken embryonic primary jejunal epithelial cells via the MAPK and PI3K/AKT/mTOR signaling pathways.
Huang L, Cao C, Lin X, Lu L, Lin X, Liu HC, Odle J, See MT, Zhang L, Wu W, Luo X, Liao X
Poultry science 2024 Jun;103(6):103696
Poultry science 2024 Jun;103(6):103696
Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.
Shi Q, Xu J, Chen C, Hu X, Wang B, Zeng F, Ren T, Huang Y, Guo W, Tang X, Ji T
Cancer letters 2024 Jun 1;591:216902
Cancer letters 2024 Jun 1;591:216902
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology.
Wei L, Li X, Yao Y, Wang S, Ai X, Liu S
Chemical biology & drug design 2024 Jan;103(1):e14421
Chemical biology & drug design 2024 Jan;103(1):e14421
Gestational exposure to 1-NP induces ferroptosis in placental trophoblasts via CYP1B1/ERK signaling pathway leading to fetal growth restriction.
Yu S, Mu Y, Wang K, Wang L, Wang C, Yang Z, Liu Y, Li S, Zhang M
Chemico-biological interactions 2024 Jan 5;387:110812
Chemico-biological interactions 2024 Jan 5;387:110812
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Xiao Y, Duan C, Gong P, Zhao Q, Wang XH, Geng F, Zeng J, Luo T, Xu Y, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Shenqu xiaoshi oral solution enhances digestive function and stabilizes the gastrointestinal microbiota of juvenile rats with infantile anorexia.
Zhao M, Xiang T, Dong Z, Liu G, Wang P, Qi X, Hao Q, Han N, Liu Z, Li S, Yin J, Zhai J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117112
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117112
KBTBD2 promotes proliferation and migration of gastric cancer via activating EGFR signaling pathway.
Ding J, Gao W, Yang H, Duan L, Sun D, Liu L, Qu X, Yu H, Xu B, Zhao S, Wang L, Chai J
Pathology, research and practice 2024 Feb;254:155095
Pathology, research and practice 2024 Feb;254:155095
The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway.
Wang X, Wu H, Tang L, Fu W, He Y, Zeng C, Wang WE
Journal of molecular and cellular cardiology 2024 Feb;187:26-37
Journal of molecular and cellular cardiology 2024 Feb;187:26-37
Farrerol suppresses osteoclast differentiation and postmenopausal osteoporosis by inhibiting the nuclear factor kappa B signaling pathway.
Lu W, Qi G, Yang X, Li D, Chen W, Zeng Q, Jiang Z
Journal of pharmacological sciences 2024 Feb;154(2):113-126
Journal of pharmacological sciences 2024 Feb;154(2):113-126
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway.
Liu XR, Li SF, Mei WY, Liu XD, Zhou RB
Chinese journal of integrative medicine 2024 Apr;30(4):299-310
Chinese journal of integrative medicine 2024 Apr;30(4):299-310
Curcumin abrogates cobalt-induced neuroinflammation by suppressing proinflammatory cytokines release, inhibiting microgliosis and modulation of ERK/MAPK signaling pathway.
Oria RS, Anyanwu GE, Nto JN, Ikpa JO
Journal of chemical neuroanatomy 2024 Apr;137:102402
Journal of chemical neuroanatomy 2024 Apr;137:102402
Exploring the Potential Mechanisms of Guanxinshutong Capsules in Treating Pathological Cardiac Hypertrophy based on Network Pharmacology, Computer-Aided Drug Design, and Animal Experiments.
Liu Y, Li Q, Shao C, She Y, Zhou H, Guo Y, An H, Wang T, Yang J, Wan H
ACS omega 2024 Apr 23;9(16):18083-18098
ACS omega 2024 Apr 23;9(16):18083-18098
Upregulated desmin/integrin β1/MAPK axis promotes elastic cartilage regeneration with increased ECM mechanical strength.
Zhang W, Lu W, Yu Q, Liu X, Jiang H
International journal of biological sciences 2023;19(9):2740-2755
International journal of biological sciences 2023;19(9):2740-2755
Tumor-derived Immunoglobulin-like transcript 4 facilitates angiogenesis of colorectal cancer.
Liu J, Zhang F, He J, Wang S, Wang L, Li J, Shi W, Han Y, Gao A, Sun Y
American journal of cancer research 2023;13(2):419-435
American journal of cancer research 2023;13(2):419-435
Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study.
Huang S, Qu M, Chen X, Yu S, Kong F
Frontiers in oncology 2023;13:1174848
Frontiers in oncology 2023;13:1174848
KRAS mutations upregulate Runx1 to promote occurrence of head and neck squamous cell carcinoma.
Deng M, Guo J, Ling Z, Zhang C, He L, Fan Z, Cheng B, Xia J
Molecular carcinogenesis 2023 Sep;62(9):1284-1294
Molecular carcinogenesis 2023 Sep;62(9):1284-1294
LINC00938 alleviates hypoxia ischemia encephalopathy induced neonatal brain injury by regulating oxidative stress and inhibiting JNK/p38 MAPK signaling pathway.
Zhao J, Le M, Li J, Huang Q, Chen H, Zhang W, Mao H, Sun Q, Li A, Zhao Y, Yu L, Yi M, Wang J, Li X, Zhang G, Ma J, Dong X
Experimental neurology 2023 Sep;367:114449
Experimental neurology 2023 Sep;367:114449
miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z, Yang W, Yang H, Zhou Z
The American journal of pathology 2023 Sep;193(9):1234-1247
The American journal of pathology 2023 Sep;193(9):1234-1247
Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
Zuo T, Xie Q, Liu J, Yang J, Shi J, Kong D, Wang Y, Zhang Z, Gao H, Zeng DB, Wang X, Tao P, Wei W, Wang J, Li Y, Long Q, Li C, Chang L, Ning H, Li Y, Cui C, Ge X, Wu J, Li G, Hong X, Yang X, Dai E, He F, Wu J, Ruan Y, Lu S, Xu P
Gastroenterology 2023 Sep;165(3):746-761.e16
Gastroenterology 2023 Sep;165(3):746-761.e16
Oncogenic BRAF noncanonically promotes tumor metastasis by mediating VASP phosphorylation and filopodia formation.
Pan W, Tian Y, Zheng Q, Yang Z, Qiang Y, Zhang Z, Zhang N, Xiong J, Zhu X, Wei L, Li F
Oncogene 2023 Oct;42(43):3194-3205
Oncogene 2023 Oct;42(43):3194-3205
Konjac glucomannan attenuate high-fat diet-fed obesity through enhancing β-adrenergic-mediated thermogenesis in inguinal white adipose tissue in mice.
Hong J, Shi Y, Chen J, Mi M, Ren Q, Zhang Y, Shen M, Bu J, Kang Y
Glycoconjugate journal 2023 Oct;40(5):575-586
Glycoconjugate journal 2023 Oct;40(5):575-586
Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia.
Ma H, Cui J, Liu Z, Fang W, Lu S, Cao S, Zhang Y, Chen JA, Lu L, Xie Q, Wang Y, Huang Y, Li K, Tong H, Huang J, Lu W
Oncogene 2023 Nov;42(45):3331-3343
Oncogene 2023 Nov;42(45):3331-3343
Nucleophilic covalent ligand discovery for the cysteine redoxome.
Fu L, Jung Y, Tian C, Ferreira RB, Cheng R, He F, Yang J, Carroll KS
Nature chemical biology 2023 Nov;19(11):1309-1319
Nature chemical biology 2023 Nov;19(11):1309-1319
Xiaozheng pill exerts an anti-mammary hyperplasia effect through Raf/ERK/ELK and HIF-1α/bFGF pathways.
Liu YF, An T, Yu H, Fan YY, Pei XH
Journal of traditional and complementary medicine 2023 Nov;13(6):600-610
Journal of traditional and complementary medicine 2023 Nov;13(6):600-610
Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance.
Zhu Y, Ye X, Shen H, Li J, Cai Z, Min W, Hou Y, Dong H, Wu Y, Wang L, Wang X, Xiao Y, Yang P
Journal of medicinal chemistry 2023 Nov 9;66(21):14633-14652
Journal of medicinal chemistry 2023 Nov 9;66(21):14633-14652
Effective-compound combination of Bufei Yishen formula III combined with ER suppress airway mucus hypersecretion in COPD rats: via EGFR/MAPK signaling.
Xu K, Ma J, Lu R, Shao X, Zhao Y, Cui L, Qiu Z, Tian Y, Li J
Bioscience reports 2023 Nov 30;43(11)
Bioscience reports 2023 Nov 30;43(11)
Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling.
Xia L, Zhang T, Yao J, Lu K, Hu Z, Gu X, Chen Y, Qin S, Leng W
iScience 2023 Nov 17;26(11):108201
iScience 2023 Nov 17;26(11):108201
EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
Luo Y, Ali T, Liu Z, Gao R, Li A, Yang C, Ling L, He L, Li S
Life sciences 2023 Nov 15;333:122102
Life sciences 2023 Nov 15;333:122102
Extracts of Oldenlandia diffusa protects chondrocytes via inhibiting apoptosis and associated inflammatory response in osteoarthritis.
Lou C, Lin C, Wang W, Jiang H, Cai T, Lin S, Xue X, Lin J, Pan X
Journal of ethnopharmacology 2023 Nov 15;316:116744
Journal of ethnopharmacology 2023 Nov 15;316:116744
Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis.
Liu K, Cao Z, Huang S, Kong F
BMC complementary medicine and therapies 2023 Nov 10;23(1):405
BMC complementary medicine and therapies 2023 Nov 10;23(1):405
Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway.
Cai X, Zhu S
Genomics 2023 May;115(3):110595
Genomics 2023 May;115(3):110595
Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC.
Dong H, Ye X, Zhu Y, Shen H, Shen H, Chen W, Ji M, Zheng M, Wang K, Cai Z, Sun H, Xiao Y, Yang P
Journal of medicinal chemistry 2023 May 25;66(10):6849-6868
Journal of medicinal chemistry 2023 May 25;66(10):6849-6868
TATA-box-binding protein-associated factor 15 is a novel biomarker that promotes cell proliferation and migration in gastrointestinal stromal tumor.
Guo CM, Tang L, Li X, Huang LY
World journal of gastroenterology 2023 May 21;29(19):2932-2949
World journal of gastroenterology 2023 May 21;29(19):2932-2949
CRYAA and GJA8 promote visual development after whisker tactile deprivation.
Zhang S, Liu C, Wang Q, Zhou H, Wu H, Zhuang J, Cao Y, Shi H, Zhang J, Wang J
Heliyon 2023 Mar;9(3):e13897
Heliyon 2023 Mar;9(3):e13897
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
The antimicrobial peptide LK2(6)A(L) exhibits anti-inflammatory activity by binding to the myeloid differentiation 2 domain and protects against LPS-induced acute lung injury in mice.
Zhang J, Sun Y, Sun C, Shang D
Bioorganic chemistry 2023 Mar;132:106376
Bioorganic chemistry 2023 Mar;132:106376
Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway.
Meng D, Deng X, Wu Y, Wu J, Zhang Y, Zhang J, Zhao Y, Che Y
Heliyon 2023 Jun;9(6):e16960
Heliyon 2023 Jun;9(6):e16960
Norepinephrine/β(2)-Adrenergic Receptor Pathway Promotes the Cell Proliferation and Nerve Growth Factor Production in Triple-Negative Breast Cancer.
Jin M, Wang Y, Zhou T, Li W, Wen Q
Journal of breast cancer 2023 Jun;26(3):268-285
Journal of breast cancer 2023 Jun;26(3):268-285
Administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors.
Zhao H, Yin Y, Lin T, Wang W, Gong L
Experimental eye research 2023 Jun;231:109486
Experimental eye research 2023 Jun;231:109486
RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse.
Chen Y, Tang R, Xiong W, Zhang F, Wang N, Xie B, Cao J, Chen Z, Ma C
Journal of translational medicine 2023 Jun 18;21(1):396
Journal of translational medicine 2023 Jun 18;21(1):396
TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
Huang Y, Chen Z, Chen X, Chen X, Xu M
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Jan;52(1):47-55
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Jan;52(1):47-55
Neuroprotective effect of histamine H3 receptor blockade on methamphetamine-induced cognitive impairment in mice.
Luo H, Li X, Fan R, Ruan Y, Qian L, Shen Y, Si Z, Li L, Liu Y
Pharmacology, biochemistry, and behavior 2023 Jan;222:173512
Pharmacology, biochemistry, and behavior 2023 Jan;222:173512
Blocking circadian clock factor Rev-erbα inhibits growth plate chondrogenesis via up-regulating MAPK-ERK1/2 pathway.
Qian Z, Liu Z, Feng Z, Cai Z, Qiu Y, Zhu Z
Cell cycle (Georgetown, Tex.) 2023 Jan;22(1):73-84
Cell cycle (Georgetown, Tex.) 2023 Jan;22(1):73-84
Angiotensin-(1-7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways.
Chen XS, Cui JR, Meng XL, Wang SH, Wei W, Gao YL, Shou ST, Liu YC, Chai YF
Journal of translational medicine 2023 Jan 2;21(1):2
Journal of translational medicine 2023 Jan 2;21(1):2
Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway.
Cheng B, Chu X, Liu R, Ma X, Wang M, Zhang J, Jiao P, Gao Q, Ma W, Zhang Y, Zhao C, Zhou D, Xiao S
Molecular pharmaceutics 2023 Jan 2;20(1):701-710
Molecular pharmaceutics 2023 Jan 2;20(1):701-710
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Han L, Dai W, Luo W, Ye L, Fang H, Mo S, Li Q, Xu Y, Wang R, Cai G
Cancers 2023 Jan 17;15(3)
Cancers 2023 Jan 17;15(3)
Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Pan B, Han B, Zhu X, Wang Y, Ji H, Weng J, Liu Y
Brain research 2023 Jan 1;1798:148153
Brain research 2023 Jan 1;1798:148153
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
He Y, Luo M, Lei S, Zeng Z, Chen T, Wu Y, Wang D, Wang L, Wang L
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-α-TAK1 signaling pathway.
Jiang YN, Yang SX, Guan X, Chen Q, Zhao L, Yu XY, Ren FF, Wu SJ, Wu LP, Lai TF, Li L
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166813
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166813
A homozygous variant in INTS11 links mitosis and neurogenesis defects to a severe neurodevelopmental disorder.
Kuang H, Li Y, Wang Y, Shi M, Duan R, Xiao Q, She H, Liu Y, Liang Q, Teng Y, Zhou M, Liang D, Li Z, Wu L
Cell reports 2023 Dec 26;42(12):113445
Cell reports 2023 Dec 26;42(12):113445
A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders.
Li A, Li W, Ali T, Yang C, Liu Z, Gao R, He K, Liu XA, Chen Z, Yu ZJ, Li T, Li S
European journal of pharmacology 2023 Dec 15;961:176174
European journal of pharmacology 2023 Dec 15;961:176174
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury via inhibiting ferroptosis by the cAMP/PKA/CREB pathway.
Ma X, Xu J, Gao N, Tian J, Song T
Molecular and cellular probes 2023 Apr;68:101899
Molecular and cellular probes 2023 Apr;68:101899
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Xie Y, Mei X, Shi W
Journal of cellular and molecular medicine 2023 Apr;27(7):982-990
Journal of cellular and molecular medicine 2023 Apr;27(7):982-990
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Qian X, Xiong S, Chen Q, Zhang J, Xie J
Experimental and therapeutic medicine 2023 Apr;25(4):150
Experimental and therapeutic medicine 2023 Apr;25(4):150
Prepubertal exposure to copper oxide nanoparticles induces Leydig cell injury with steroidogenesis disorders in mouse testes.
Zheng X, Chen J, Kang L, Wei Y, Wu Y, Hong Y, Wang X, Li D, Shen L, Long C, Wei G, Wu S
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Biochemical and biophysical research communications 2023 Apr 30;654:62-72
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling.
Xu X, Deng L, Tang Y, Li J, Zhong T, Hao X, Fan Y, Mu S
International journal of molecular sciences 2023 Apr 30;24(9)
International journal of molecular sciences 2023 Apr 30;24(9)
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Wang Y, Gao J, Sun L, Li Q, Kang N, Gao C, Li T
Journal of ethnopharmacology 2023 Apr 24;306:116180
Journal of ethnopharmacology 2023 Apr 24;306:116180
TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.
Tang L, Guo C, Li X, Zhang B, Huang L
Scientific reports 2023 Apr 10;13(1):5846
Scientific reports 2023 Apr 10;13(1):5846
The Effect of Bone Morphogenetic Protein 2 or Extracellular Signal-Regulated Kinase 1 Silencing on Phosphorus Utilization and Related Parameters in Primary Broiler Osteoblasts.
Geng Y, Li T, Hu Y, Zhang L, Cui X, Zhu L, Wu B, Luo X
Frontiers in veterinary science 2022;9:943864
Frontiers in veterinary science 2022;9:943864
Optimization of murine retinal mitochondrial injury model.
Zhou X, Fang G, Zhang L
MethodsX 2022;9:101701
MethodsX 2022;9:101701
Morroniside Protects Human Granulosa Cells against H(2)O(2)-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways.
Ma Y, Hao G, Lin X, Zhao Z, Yang A, Cao Y, Zhang S, Fan L, Geng J, Zhang Y, Chen J, Song C, He M, Du H
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8099724
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8099724
Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.
Chen A, Xu M, Chen J, Chen T, Wang Q, Zhang R, Qiu J
BioMed research international 2022;2022:6207701
BioMed research international 2022;2022:6207701
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Chen X, Yang G, Guo X, Zhang J, Sun W, Liu D, Wang H, Liu S
Oxidative medicine and cellular longevity 2022;2022:2543220
Oxidative medicine and cellular longevity 2022;2022:2543220
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca(2+)-FOXO1 pathway.
Huang JC, Duan CC, Jin S, Sheng CB, Wang YS, Yue ZP, Guo B
International journal of biological sciences 2022;18(5):2047-2059
International journal of biological sciences 2022;18(5):2047-2059
The Immune-Enhancing Properties of Hwanglyeonhaedok-Tang-Mediated Biosynthesized Gold Nanoparticles in Macrophages and Splenocytes.
Mi XJ, Xu XY, Choi HS, Kim H, Cho IH, Yi TH, Kim YJ
International journal of nanomedicine 2022;17:477-494
International journal of nanomedicine 2022;17:477-494
Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence.
Liu D, Lin S, Li Y, Zhou T, Hu K, Li Q
Drug design, development and therapy 2022;16:375-395
Drug design, development and therapy 2022;16:375-395
Chrysophanol-8-O-glucoside protects mice against acute liver injury by inhibiting autophagy in hepatic stellate cells and inflammatory response in liver-resident macrophages.
Wang T, Lu Z, Qu XH, Xiong ZY, Wu YT, Luo Y, Zhang ZY, Han XJ, Xie CF
Frontiers in pharmacology 2022;13:951521
Frontiers in pharmacology 2022;13:951521
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Bai Y, Chen J, Hu W, Wang L, Wu Y, Yu S
Frontiers in pharmacology 2022;13:847905
Frontiers in pharmacology 2022;13:847905
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Neobavaisoflavone inhibits allergic inflammatory responses by suppressing mast cell activation.
Liang R, Yuan Y, Bai Y, Liu X, Chen J, Jiang D, Meng D, Chen G, Li B, Zhou L, Guo W
International immunopharmacology 2022 Sep;110:108953
International immunopharmacology 2022 Sep;110:108953
Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Wu S, Edwards H, Wang D, Liu S, Qiao X, Carter J, Wang Y, Taub JW, Wang G, Ge Y
Cells 2022 Sep 3;11(17)
Cells 2022 Sep 3;11(17)
Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway.
Zou M, Fu Y, Zhao Y, Sun Y, Yin X, Peng X
International immunopharmacology 2022 Oct;111:109090
International immunopharmacology 2022 Oct;111:109090
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance.
Wang C, Long Q, Fu Q, Xu Q, Fu D, Li Y, Gao L, Guo J, Zhang X, Lam EW, Campisi J, Sun Y
Oncogene 2022 Nov;41(45):4941-4959
Oncogene 2022 Nov;41(45):4941-4959
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
Chen XS, Wang SH, Liu CY, Gao YL, Meng XL, Wei W, Shou ST, Liu YC, Chai YF
Pharmacological research 2022 Nov;185:106473
Pharmacological research 2022 Nov;185:106473
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling.
Liu X, He H, Zhang F, Hu X, Bi F, Li K, Yu H, Zhao Y, Teng X, Li J, Wang L, Zhang Y, Wu Q
Cell death & disease 2022 May 21;13(5):483
Cell death & disease 2022 May 21;13(5):483
Induction of COX-2 by feline calicivirus via activation of the MEK1-ERK1/2 pathway, and attenuation of feline lung inflammation and injury by MEK1 inhibitor AZD6244 (selumetinib).
Liu Y, Shi WD, Xie QQ, Wang JG, Gu CC, Ji ZH, Xiao J, Liu WQ
Biochemical and biophysical research communications 2022 May 14;604:8-13
Biochemical and biophysical research communications 2022 May 14;604:8-13
The adenosine A(2A) receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.
Fang G, Zhou Y, Zhou X, Zhou H, Ge YY, Luo S, Chen JF, Zhang L
Neuropharmacology 2022 May 1;208:108981
Neuropharmacology 2022 May 1;208:108981
CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5.
Pan G, Zhang J, Han Y, Chen Y, Guo X, Cui X, Cheng M, Gao H, Wang J, Jiang F
Pharmacological research 2022 Mar;177:106120
Pharmacological research 2022 Mar;177:106120
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.
Jiang G, Sun C, Wang X, Mei J, Li C, Zhan H, Liao Y, Zhu Y, Mao J
Bioengineered 2022 Mar;13(3):5216-5235
Bioengineered 2022 Mar;13(3):5216-5235
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Meng N, Chen K, Wang Y, Hou J, Chu W, Xie S, Yang F, Sun C
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Shu J, Hu L, Wu Y, Chen L, Huang K, Wang Z, Liang M
European journal of pharmacology 2022 Mar 15;919:174805
European journal of pharmacology 2022 Mar 15;919:174805
Homer1 promotes the conversion of A1 astrocytes to A2 astrocytes and improves the recovery of transgenic mice after intracerebral hemorrhage.
Fei X, Dou YN, Wang L, Wu X, Huan Y, Wu S, He X, Lv W, Wei J, Fei Z
Journal of neuroinflammation 2022 Mar 14;19(1):67
Journal of neuroinflammation 2022 Mar 14;19(1):67
CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases.
Xue B, Wang P, Yu W, Feng J, Li J, Zhao R, Yang Z, Yan X, Duan H
Science China. Life sciences 2022 Jun;65(6):1157-1170
Science China. Life sciences 2022 Jun;65(6):1157-1170
CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway.
Zhang J, Zhang X, Zou Y, Han F
Archives of physiology and biochemistry 2022 Jun;128(3):708-715
Archives of physiology and biochemistry 2022 Jun;128(3):708-715
Geniposide alleviates VEGF-induced angiogenesis by inhibiting VEGFR2/PKC/ERK1/2-mediated SphK1 translocation.
Wang Y, Wu H, Gui BJ, Liu J, Rong GX, Deng R, Bu YH, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154068
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154068
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Chen C, Guo Y, Huang Q, Wang B, Wang W, Niu J, Lou J, Xu J, Ren T, Huang Y, Guo W
Cancer letters 2022 Jun 28;536:215660
Cancer letters 2022 Jun 28;536:215660
The role and mechanism of TLR4-siRNA in the impairment of learning and memory in young mice induced by isoflurane.
Lin L, Chen D, Yu X, Zhong W, Liu Y, Feng Y, Luo H
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2022 Jul;31(7):769-780
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2022 Jul;31(7):769-780
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Zhou Q, Gong J, Bi J, Yang X, Zhang L, Lu C, Li L, Chen M, Cai J, Yang R, Li X, Li Z, Wang X
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.
Luo F, Wang J, Zhang Z, You Z, Bedolla A, Okwubido-Williams F, Huang LF, Silver J, Luo Y
Cell reports 2022 Jul 26;40(4):111137
Cell reports 2022 Jul 26;40(4):111137
GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis.
Cao C, Zhou Y, Zhang Y, Ma Y, Du S, Fan L, Niu R, Zhang Y, He M
iScience 2022 Jul 15;25(7):104509
iScience 2022 Jul 15;25(7):104509
Acacetin attenuates Streptococcus suis virulence by simultaneously targeting suilysin and inflammation.
Xie S, Zhang Y, Xu L, Li S, Shen X, Li L, Deng X, Zhou Y
Microbial pathogenesis 2022 Jan;162:105354
Microbial pathogenesis 2022 Jan;162:105354
TSH-TSHR axis promotes tumor immune evasion.
Wu Z, Xi Z, Xiao Y, Zhao X, Li J, Feng N, Hu L, Zheng R, Zhang N, Wang S, Huang T
Journal for immunotherapy of cancer 2022 Jan;10(1)
Journal for immunotherapy of cancer 2022 Jan;10(1)
Immune-enhancing effects of postbiotic produced by Bacillus velezensis Kh2-2 isolated from Korea Foods.
Mi XJ, Tran THM, Park HR, Xu XY, Subramaniyam S, Choi HS, Kim J, Koh SC, Kim YJ
Food research international (Ottawa, Ont.) 2022 Feb;152:110911
Food research international (Ottawa, Ont.) 2022 Feb;152:110911
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway.
Liang L, Liu L, Zhou W, Yang C, Mai G, Li H, Chen Y
Clinical science (London, England : 1979) 2022 Feb 25;136(4):291-307
Clinical science (London, England : 1979) 2022 Feb 25;136(4):291-307
WT1 suppresses follicle-stimulating hormone-induced progesterone secretion by regulating ERK1/2 pathway in chicken preovulatory granulosa cells.
Tang S, Li X, Wu X, Gong Y
Gene 2022 Feb 20;812:146097
Gene 2022 Feb 20;812:146097
Employing CRISPR-Cas9 to Generate CD133 Synthetic Lethal Melanoma Stem Cells.
Simbulan-Rosenthal CM, Haribabu Y, Vakili S, Kuo LW, Clark H, Dougherty R, Alobaidi R, Carney B, Sykora P, Rosenthal DS
International journal of molecular sciences 2022 Feb 20;23(4)
International journal of molecular sciences 2022 Feb 20;23(4)
Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice.
Li T, Li X, Huang X, Yu H, Li S, Zhang Z, Xie Y, Song X, Liu J, Yang X, Liu G
Neuropharmacology 2022 Feb 15;204:108899
Neuropharmacology 2022 Feb 15;204:108899
Classical Signaling and Trans-Signaling Pathways Stimulated by Megalobrama amblycephala IL-6 and IL-6R.
Wang J, Sun Q, Zhang J, Wang H, Liu H
International journal of molecular sciences 2022 Feb 11;23(4)
International journal of molecular sciences 2022 Feb 11;23(4)
Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways.
Shen Y, Teng L, Qu Y, Liu J, Zhu X, Chen S, Yang L, Huang Y, Song Q, Fu Q
Journal of ethnopharmacology 2022 Feb 10;284:114791
Journal of ethnopharmacology 2022 Feb 10;284:114791
Antidepressant effects of total alkaloids of Fibraurea recisa on improving corticosterone-induced apoptosis of HT-22 cells and chronic unpredictable mild stress-induced depressive-like behaviour in mice.
He Z, Yu H, Wu H, Su L, Shi K, Zhao Y, Zong Y, Chen W, Du R
Pharmaceutical biology 2022 Dec;60(1):1436-1448
Pharmaceutical biology 2022 Dec;60(1):1436-1448
4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer.
Wang Y, Lei J, Zhang S, Wang X, Jin J, Liu Y, Gan M, Yuan Y, Sun L, Li X, Han T, Wang JB
Cell death & disease 2022 Dec 27;13(12):1075
Cell death & disease 2022 Dec 27;13(12):1075
Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages.
Wen Y, Chen Z, Tian Y, Yang M, Dong Q, Yang Y, Ding H
Veterinary research 2022 Aug 4;53(1):62
Veterinary research 2022 Aug 4;53(1):62
Kaempferol-Driven Inhibition of Listeriolysin O Pore Formation and Inflammation Suppresses Listeria monocytogenes Infection.
Wang T, Liu B, Zhang C, Fang T, Ding Y, Song G, Zhang S, Shi L, Deng X, Wang J
Microbiology spectrum 2022 Aug 31;10(4):e0181022
Microbiology spectrum 2022 Aug 31;10(4):e0181022
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix.
Song S, Qiu R, Jin X, Zhou Z, Yan J, Ou Q, Liu X, Li W, Mao Y, Yao W, Lu T
Journal of ethnopharmacology 2022 Apr 6;287:114911
Journal of ethnopharmacology 2022 Apr 6;287:114911
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
Lu H, Yin H, Qu L, Ma X, Fu R, Fan D
Food & function 2022 Apr 4;13(7):3793-3811
Food & function 2022 Apr 4;13(7):3793-3811
GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation.
Huang T, Meng F, Huang H, Wang L, Wang L, Liu Y, Liu Y, Wang J, Li W, Zhang J, Liu Y
Biochemical and biophysical research communications 2022 Apr 23;601:16-23
Biochemical and biophysical research communications 2022 Apr 23;601:16-23
Astrocytes Derived from Familial and Sporadic Alzheimer's Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau.
Brezovakova V, Sykova E, Jadhav S
Cells 2022 Apr 22;11(9)
Cells 2022 Apr 22;11(9)
Dihydromyricetin Enhances Intestinal Antioxidant Capacity of Growing-Finishing Pigs by Activating ERK/Nrf2/HO-1 Signaling Pathway.
Wei C, Chen X, Chen D, Yu B, Zheng P, He J, Chen H, Yan H, Luo Y, Huang Z
Antioxidants (Basel, Switzerland) 2022 Apr 2;11(4)
Antioxidants (Basel, Switzerland) 2022 Apr 2;11(4)
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu NJ, Xi RY, Shi XK, Li RZ, Zhang ZH, Li LY, Zhang GL, Wang F
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Toxicology and applied pharmacology 2022 Apr 15;441:115988
piR-121380 Is Involved in Cryo-Capacitation and Regulates Post-Thawed Boar Sperm Quality Through Phosphorylation of ERK2 via Targeting PTPN7.
Wang Y, Yuan X, Ali MA, Qin Z, Zhang Y, Zeng C
Frontiers in cell and developmental biology 2021;9:792994
Frontiers in cell and developmental biology 2021;9:792994
m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.
Liu Z, Lu J, Fang H, Sheng J, Cui M, Yang Y, Tang B, Zhang X
Frontiers in cell and developmental biology 2021;9:783385
Frontiers in cell and developmental biology 2021;9:783385
Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways.
Li H, Zhang Y, Lan X, Yu J, Yang C, Sun Z, Kang P, Han Y, Yu D
Frontiers in cell and developmental biology 2021;9:773048
Frontiers in cell and developmental biology 2021;9:773048
Acer Truncatum Seed Oil Alleviates Learning and Memory Impairments of Aging Mice.
Li X, Li T, Hong XY, Liu JJ, Yang XF, Liu GP
Frontiers in cell and developmental biology 2021;9:680386
Frontiers in cell and developmental biology 2021;9:680386
The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment.
Kong Y, Huang L, Li W, Liu X, Zhou Y, Liu C, Zhang S, Xie F, Zhang Z, Jiang D, Zhou W, Ni R, Zhang C, Sun B, Wang J, Guan Y
Frontiers in cell and developmental biology 2021;9:609908
Frontiers in cell and developmental biology 2021;9:609908
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation.
Liu L, Luo F, Lei K
Mediators of inflammation 2021;2021:9960241
Mediators of inflammation 2021;2021:9960241
BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.
Wan Y, Song M, Xie X, Chen Z, Gao Z, Wu X, Huang R, Chen M
Mediators of inflammation 2021;2021:5522291
Mediators of inflammation 2021;2021:5522291
SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
Zeng B, Sun Z, Zhao Q, Liu D, Chen H, Li X, Xing HR, Wang J
International journal of biological sciences 2021;17(12):3000-3012
International journal of biological sciences 2021;17(12):3000-3012
Tetramethylpyrazine Alleviates Behavioral and Psychological Symptoms of Dementia Through Facilitating Hippocampal Synaptic Plasticity in Rats With Chronic Cerebral Hypoperfusion.
Tan Z, Qiu J, Zhang Y, Yang Q, Yin X, Li J, Liu G, Li H, Yang G
Frontiers in neuroscience 2021;15:646537
Frontiers in neuroscience 2021;15:646537
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X
Drug design, development and therapy 2021;15:51-60
Drug design, development and therapy 2021;15:51-60
Myosin 1b promotes migration, invasion and glycolysis in cervical cancer via ERK/HIF-1α pathway.
Wen LJ, Hu XL, Li CY, Liu J, Li ZY, Li YZ, Zhou JY
American journal of translational research 2021;13(11):12536-12548
American journal of translational research 2021;13(11):12536-12548
MALAT-1 is Associated with the Doxorubicin Resistance in U-2OS Osteosarcoma Cells.
Liu C, Han X, Li B, Huang S, Zhou Z, Wang Z, Wang W
Cancer management and research 2021;13:6879-6889
Cancer management and research 2021;13:6879-6889
Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS.
Qiao Z, Li J, Kou H, Chen X, Bao D, Shang G, Chen S, Ji Y, Cheng T, Wang Y, Liu H
Frontiers in genetics 2021;12:789823
Frontiers in genetics 2021;12:789823
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Cai C, Hu W, Zhang Y, Hu X, Yang S, Qiu H, Wang R, Ma M, Qiu Y, Chu T
Frontiers in pharmacology 2021;12:772540
Frontiers in pharmacology 2021;12:772540
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Gao M, Yang J, Gong H, Lin Y, Liu J
Frontiers in pharmacology 2021;12:760055
Frontiers in pharmacology 2021;12:760055
Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non-small-Cell Lung Cancer In Vivo and In Vitro.
Sun CY, Cao D, Ren QN, Zhang SS, Zhou NN, Mai SJ, Feng B, Wang HY
Frontiers in pharmacology 2021;12:684243
Frontiers in pharmacology 2021;12:684243
Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.
Zheng CQ, Fan HX, Li XX, Li JJ, Sheng S, Zhang F
Frontiers in immunology 2021;12:683577
Frontiers in immunology 2021;12:683577
Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway.
Chen P, Wen Z, Shi W, Li Z, Chen X, Gao Y, Xu S, Gong Q, Deng J
Frontiers in pharmacology 2021;12:674570
Frontiers in pharmacology 2021;12:674570
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.
Wu F, Zhao Y, Shao Q, Fang K, Dong R, Jiang S, Lu F, Luo J, Chen G
Frontiers in pharmacology 2021;12:646331
Frontiers in pharmacology 2021;12:646331
XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression.
Yang WQ, Zhao WJ, Zhu LL, Xu SJ, Zhang XL, Liang Y, Ding XF, Kiselyov A, Chen G
Frontiers in pharmacology 2021;12:603453
Frontiers in pharmacology 2021;12:603453
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
Zhao J, Jiang Y, Chen L, Ma Y, Zhang H, Zhou J, Li H, Jing Z
Frontiers in oncology 2021;11:699933
Frontiers in oncology 2021;11:699933
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.
Wang J, Li H, Wang L, Zhang J, Li M, Qiao L, Zhang J, Liu L, Zhang C, Gao J, Li W
Frontiers in oncology 2021;11:681250
Frontiers in oncology 2021;11:681250
A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo.
Yan Y, Cheng X, Li L, Zhang R, Zhu Y, Wu Z, Ding K
Frontiers in oncology 2021;11:669393
Frontiers in oncology 2021;11:669393
miRNA‑7515 suppresses pancreatic cancer cell proliferation, migration and invasion via downregulating IGF‑1 expression.
Lei S, Zeng Z, He Z, Cao W
Oncology reports 2021 Sep;46(3)
Oncology reports 2021 Sep;46(3)
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Ma D, Liu P, Wang P, Zhou Z, Fang Q, Wang J
Journal of cellular physiology 2021 Sep;236(9):6312-6327
Journal of cellular physiology 2021 Sep;236(9):6312-6327
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
Wu J, Wu T, Zheng S, Huang Y, Wang L
Experimental eye research 2021 Sep;210:108696
Experimental eye research 2021 Sep;210:108696
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Ni L, Wei Y, Pan J, Li X, Xu B, Deng Y, Yang T, Liu W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Sep;155:112386
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Hu B, Qin C, Li L, Wei L, Mo X, Fan H, Lei Y, Wei F, Zou D
Cancer cell international 2021 Sep 23;21(1):509
Cancer cell international 2021 Sep 23;21(1):509
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Li R, Qi Y, Yuan Q, Xu L, Gao M, Xu Y, Han X, Yin L, Liu C
European journal of pharmacology 2021 Sep 15;907:174277
European journal of pharmacology 2021 Sep 15;907:174277
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, Wang Z, Huang J, Wang W, Liu T, Xue W, Chen G
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
CCL2 is a critical mechano-responsive mediator in crosstalk between osteoblasts and bone mesenchymal stromal cells.
Yao Z, Chen P, Fan L, Chen P, Zhang X, Yu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21851
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21851
Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke.
Chen YD, Huang PY, Chiang CS, Huang YS, Tang SC
Molecular neurobiology 2021 Nov;58(11):5814-5825
Molecular neurobiology 2021 Nov;58(11):5814-5825
Silencing ACTG1 Expression Induces Prostate Cancer Epithelial Mesenchymal Transition Through MAPK/ERK Signaling Pathway.
Xiao L, Peng H, Yan M, Chen S
DNA and cell biology 2021 Nov;40(11):1445-1455
DNA and cell biology 2021 Nov;40(11):1445-1455
Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways.
Tao Y, Sun Y, Wu B, Xu D, Yang J, Gu L, Du C
International immunopharmacology 2021 May;94:107427
International immunopharmacology 2021 May;94:107427
Protective effect of Apelin/APJ system on lipopolysaccharide-related cardiac dysfunction.
Hu J, Huo S, Dou S, Jiang W, Li Y
General physiology and biophysics 2021 May;40(3):161-171
General physiology and biophysics 2021 May;40(3):161-171
Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways.
Cao Y, Zhang Y, Ma L, Wang J, Guo W, Cheng J, Hu G, Fu S, Liu J
Cell and tissue research 2021 May;384(2):313-324
Cell and tissue research 2021 May;384(2):313-324
Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
Gao C, Jia W, Xu W, Wu Q, Wu J
Journal of neuroinflammation 2021 May 22;18(1):118
Journal of neuroinflammation 2021 May 22;18(1):118
ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.
Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566
Journal of hazardous materials 2021 May 15;410:124566
Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma.
Yang H, Liu Y, Zhao MM, Guo Q, Zheng XK, Liu D, Zeng KW, Tu PF
Cell death & disease 2021 May 14;12(5):492
Cell death & disease 2021 May 14;12(5):492
Effects of dietary icariin supplementation on the ovary development-related transcriptome of Chinese mitten crab (Eriocheir sinensis).
Zheng X, Zhang L, Jiang W, Abasubong KP, Zhang C, Zhang D, Li X, Jiang G, Chi C, Liu W
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2021 Mar;37:100756
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2021 Mar;37:100756
The RNA-Binding Protein CELF2 Inhibits Ovarian Cancer Progression by Stabilizing FAM198B.
Guo Q, Wu Y, Guo X, Cao L, Xu F, Zhao H, Zhu J, Wen H, Ju X, Wu X
Molecular therapy. Nucleic acids 2021 Mar 5;23:169-184
Molecular therapy. Nucleic acids 2021 Mar 5;23:169-184
miR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells.
Chen D, Su H, Li Y, Wu X, Li Y, Wei C, Shi D, Gao Y, Zhou Q, Wang Q, Jin X, Xie C
Aging 2021 Mar 10;13(7):9566-9581
Aging 2021 Mar 10;13(7):9566-9581
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Qiao X, Ma J, Knight T, Su Y, Edwards H, Polin L, Li J, Kushner J, Dzinic SH, White K, Wang J, Lin H, Wang Y, Wang L, Wang G, Taub JW, Ge Y
Blood cancer journal 2021 Jun 7;11(6):111
Blood cancer journal 2021 Jun 7;11(6):111
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer.
Li J, Chen X, Zhu L, Lao Z, Zhou T, Zang L, Ge W, Jiang M, Xu J, Cao Y, Du S, Yu Y, Fan G, Wang H
Oncogene 2021 Jul;40(30):4884-4893
Oncogene 2021 Jul;40(30):4884-4893
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Du W, Gao A, Herman JG, Wang L, Zhang L, Jiao S, Guo M
Cancer science 2021 Jul;112(7):2870-2883
Cancer science 2021 Jul;112(7):2870-2883
Adiponectin agonist treatment in diabetic pregnant rats.
Gázquez A, Rodríguez F, Sánchez-Campillo M, Martínez-Gascón LE, Arnao MB, Saura-Garre P, Albaladejo-Otón MD, Larqué E
The Journal of endocrinology 2021 Jul 22;251(1):1-13
The Journal of endocrinology 2021 Jul 22;251(1):1-13
NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
Liu Y, Nie X, Zhu J, Wang T, Li Y, Wang Q, Sun Z
Journal of cellular and molecular medicine 2021 Jan;25(2):1221-1237
Journal of cellular and molecular medicine 2021 Jan;25(2):1221-1237
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
Liu Y, Deng J, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925
Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice.
Wang X, Cheng K, Liu Z, Sun Y, Zhou L, Xu M, Dai X, Xiong Y, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153804
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153804
PDGF-BB promotes vascular smooth muscle cell migration by enhancing Pim-1 expression via inhibiting miR-214.
Zhou J, Shao L, Yu J, Huang J, Feng Q
Annals of translational medicine 2021 Dec;9(23):1728
Annals of translational medicine 2021 Dec;9(23):1728
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Huang S, Tan Z, Cai J, Wang Z, Tian Y
Pharmaceutical biology 2021 Dec;59(1):584-593
Pharmaceutical biology 2021 Dec;59(1):584-593
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Cui Y, Wang Y, Liu G
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Pharmaceutical biology 2021 Dec;59(1):1305-1313
miR-483-3p Promotes IL-33 Production from Fibroblast-Like Synoviocytes by Regulating ERK Signaling in Rheumatoid Arthritis.
Zhang K, Fu W, Zhao S, Jiao T, Wu D, Wang Y
Inflammation 2021 Dec;44(6):2302-2308
Inflammation 2021 Dec;44(6):2302-2308
Qihuzha granule attenuated LPS-induced acute spleen injury in mice via Src/MAPK/Stat3 signal pathway.
Zhong T, Feng M, Su M, Wang D, Li Q, Jia S, Luo F, Wang H, Hu E, Yang X, Fan Y
Journal of ethnopharmacology 2021 Dec 5;281:114458
Journal of ethnopharmacology 2021 Dec 5;281:114458
Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression.
Lv W, Tan Y, Xiong M, Zhao C, Wang Y, Wu M, Wu Y, Zhang Q
Journal of translational medicine 2021 Dec 24;19(1):527
Journal of translational medicine 2021 Dec 24;19(1):527
Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells.
Qiu W, Guo X, Li B, Wang J, Qi Y, Chen Z, Zhao R, Deng L, Qian M, Wang S, Zhang Z, Guo Q, Zhang S, Pan Z, Zhao S, Xue H, Li G
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3449-3464
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Dec 1;29(12):3449-3464
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.
Wang X, Chen S, Zhao L, Shi X
International immunopharmacology 2021 Aug;97:107506
International immunopharmacology 2021 Aug;97:107506
Sirtuin 3 deficiency aggravates angiotensin II-induced hypertensive cardiac injury by the impairment of lymphangiogenesis.
Zhang C, Li N, Suo M, Zhang C, Liu J, Liu L, Qi Y, Zheng X, Xie L, Hu Y, Bu P
Journal of cellular and molecular medicine 2021 Aug;25(16):7760-7771
Journal of cellular and molecular medicine 2021 Aug;25(16):7760-7771
Paradoxical changes in mood-related behaviors on continuous social isolation after weaning.
Matsumoto H, Omata N, Kiyono Y, Mizuno T, Mita K, Kosaka H
Experimental brain research 2021 Aug;239(8):2537-2550
Experimental brain research 2021 Aug;239(8):2537-2550
Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.
Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513
Bone & joint research 2021 Aug;10(8):498-513
HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.
Sun W, Li S, Tang G, Sun S, Luo Y, Bai R, Han L, Jiang X, Gao Y, Huang Z, Zhang J, Gong Y, Xie C
Cancer medicine 2021 Aug;10(15):5256-5269
Cancer medicine 2021 Aug;10(15):5256-5269
Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway.
Huang F, Gao T, Wang W, Wang L, Xie Y, Tai C, Liu S, Cui Y, Wang B
Stem cell research & therapy 2021 Aug 21;12(1):468
Stem cell research & therapy 2021 Aug 21;12(1):468
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
Liao Y, Xu J, Qin B, Shi J, Qin C, Xie F, Ou S, Tang J, Wang W, Wu F, Bai L
Free radical biology & medicine 2021 Aug 20;172:33-47
Free radical biology & medicine 2021 Aug 20;172:33-47
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Zhou S, He Y, Zhang W, Xiong Y, Jiang L, Wang J, Cui X, Qu Y, Ge F
Journal of ethnopharmacology 2021 Aug 10;276:114189
Journal of ethnopharmacology 2021 Aug 10;276:114189
Synergistic effect of PAF inhibition and X-ray irradiation in non-small cell lung cancer cells.
Chen Y, Jin Y, Ying H, Zhang P, Chen M, Hu X
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2021 Apr;197(4):343-352
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2021 Apr;197(4):343-352
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Liu J, Han YS, Liu L, Tang L, Yang H, Meng P, Zhao HQ, Wang YH
Neural regeneration research 2021 Apr;16(4):727-733
Neural regeneration research 2021 Apr;16(4):727-733
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Yuan J, Che S, Ruan Z, Song L, Tang R, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
Ma D, Pan Z, Chang Q, Zhang JJ, Liu X, Hua N, Li GH
BMC cancer 2021 Apr 8;21(1):377
BMC cancer 2021 Apr 8;21(1):377
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.
Lou HX, Fu WC, Chen JX, Li TT, Jiang YY, Liu CH, Zhang W
BMC complementary medicine and therapies 2021 Apr 22;21(1):128
BMC complementary medicine and therapies 2021 Apr 22;21(1):128
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Yuan J, Che S, Zhang L, Ruan Z
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways.
Zhou J, Zhang X, Wan L, Yu J, Li T, Lu Z, Fang N, Sun L, Ye F
Medical science monitor : international medical journal of experimental and clinical research 2021 Apr 14;27:e929438
Medical science monitor : international medical journal of experimental and clinical research 2021 Apr 14;27:e929438
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Ma D, Liu X, Zhang JJ, Zhao JJ, Xiong YJ, Chang Q, Wang HY, Su P, Meng J, Zhao YB
Frontiers in cardiovascular medicine 2020;7:592550
Frontiers in cardiovascular medicine 2020;7:592550
PBX3 Promotes Tumor Growth and Angiogenesis via Activation of AT1R/VEGFR2 Pathway in Papillary Thyroid Carcinoma.
Chen Q, Yu WY, Zhang HH, Zhang SZ, Fang J, Wu F, Ying HZ, Yu CH
BioMed research international 2020;2020:8954513
BioMed research international 2020;2020:8954513
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling.
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z
Oxidative medicine and cellular longevity 2020;2020:7950457
Oxidative medicine and cellular longevity 2020;2020:7950457
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Xing J, Li P, Hong J, Wang M, Liu Y, Gao Y, Dong J, Gu H, Li L
Mediators of inflammation 2020;2020:4121750
Mediators of inflammation 2020;2020:4121750
Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats.
Wang X, Guo RZ, Ma L, Ding QY, Meng JH, Chen YG, Wu JH
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3107290
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3107290
Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.
Song W, Lv Y, Tang Z, Nie F, Huang P, Pei Q, Guo R
Cardiovascular therapeutics 2020;2020:1795853
Cardiovascular therapeutics 2020;2020:1795853
Wnt5a/CaMKII/ERK/CCL2 axis is required for tumor-associated macrophages to promote colorectal cancer progression.
Liu Q, Song J, Pan Y, Shi D, Yang C, Wang S, Xiong B
International journal of biological sciences 2020;16(6):1023-1034
International journal of biological sciences 2020;16(6):1023-1034
25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity.
Lv S, Ju C, Peng J, Liang M, Zhu F, Wang C, Huang K, Cheng M, Zhang F
International journal of biological sciences 2020;16(2):298-308
International journal of biological sciences 2020;16(2):298-308
GRHL2 Upregulation Predicts a Poor Prognosis and Promotes the Resistance of Serous Ovarian Cancer to Cisplatin.
Nie Y, Ding Y, Yang M
OncoTargets and therapy 2020;13:6303-6314
OncoTargets and therapy 2020;13:6303-6314
FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway.
Zheng P, Li L
OncoTargets and therapy 2020;13:451-463
OncoTargets and therapy 2020;13:451-463
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Zong J, Jiang J, Shi P, Liu J, Wang W, Li B, Zhao T, Pan T, Zhang Z, Bi L, Diao Y, Wang S
American journal of translational research 2020;12(2):478-492
American journal of translational research 2020;12(2):478-492
Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus.
Geng L, Tang X, Wang S, Sun Y, Wang D, Tsao BP, Feng X, Sun L
Frontiers in immunology 2020;11:233
Frontiers in immunology 2020;11:233
A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection.
Wang T, Zhang P, Lv H, Deng X, Wang J
Frontiers in cellular and infection microbiology 2020;10:330
Frontiers in cellular and infection microbiology 2020;10:330
Splenectomy enhances the Ly6C(low) phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis.
Zheng Z, Wang H, Li L, Zhang S, Zhang C, Zhang H, Ji F, Liu X, Zhu K, Kong G, Li Z
International immunopharmacology 2020 Sep;86:106762
International immunopharmacology 2020 Sep;86:106762
Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.
Leng L, Ma J, Lv L, Wang W, Gao D, Zhu Y, Wu Z
Stem cell research & therapy 2020 Sep 23;11(1):415
Stem cell research & therapy 2020 Sep 23;11(1):415
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Li P, Ding L, Cao S, Feng X, Zhang Q, Chen Y, Zhang N, Qiu F
Journal of ethnopharmacology 2020 Sep 15;259:113015
Journal of ethnopharmacology 2020 Sep 15;259:113015
Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
Xu T, Xu L, Meng P, Ma X, Yang X, Zhou Y, Feng M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13548-13560
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Oct;34(10):13548-13560
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224
Molecular medicine reports 2020 Oct;22(4):3213-3224
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Yu Z, Yang L, Deng S, Liang M
European journal of pharmacology 2020 Oct 15;885:173399
European journal of pharmacology 2020 Oct 15;885:173399
Bazedoxifene inhibits PDGF-BB induced VSMC phenotypic switch via regulating the autophagy level.
Song W, Gao K, Huang P, Tang Z, Nie F, Jia S, Guo R
Life sciences 2020 Oct 15;259:118397
Life sciences 2020 Oct 15;259:118397
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Yu ZY, Jiang XY, Zhao RR, Luo CJ, Ren YX, Ma ZJ, Ye HL, Shi WG, Wang C, Jiao ZY
Neoplasma 2020 Nov;67(6):1303-1313
Neoplasma 2020 Nov;67(6):1303-1313
Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens.
Zhu X, Mao Y, Guo M, Yu H, Hao L, Hua Q, Lu Z, Hong M, An F
Journal of bioscience and bioengineering 2020 Nov;130(5):457-463
Journal of bioscience and bioengineering 2020 Nov;130(5):457-463
Functionalized graphene oxide against U251 glioma cells and its molecular mechanism.
Wang P, Wang X, Tang Q, Chen H, Zhang Q, Jiang H, Wang Z
Materials science & engineering. C, Materials for biological applications 2020 Nov;116:111187
Materials science & engineering. C, Materials for biological applications 2020 Nov;116:111187
TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling.
Guo Y, Cao F, Hu S, Liu S, Sun H, Li A, Li F
Discovery medicine 2020 Nov-Dec;30(161):145-153
Discovery medicine 2020 Nov-Dec;30(161):145-153
Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.
Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)
FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro.
Zhang W, Bai S, Yang J, Zhang Y, Liu Y, Nie J, Meng D, Shi R, Yao Z, Wang M, Wang H, Li C
Neuroscience letters 2020 Nov 1;738:135322
Neuroscience letters 2020 Nov 1;738:135322
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling.
Wu Z, Cheng Y, Yang Y, Gao Y, Sun X, Wang L, Sun Q, Zhang J, Xu X
International journal of biological macromolecules 2020 May 1;150:802-813
International journal of biological macromolecules 2020 May 1;150:802-813
Silencing of DHX32 increases the proliferation of liver cancer cells.
Cai MJ, Zhu JH, He JQ, Zhang ZY, Liang XM
Translational cancer research 2020 Mar;9(3):1833-1842
Translational cancer research 2020 Mar;9(3):1833-1842
Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression.
Liu Q, Yang C, Wang S, Shi D, Wei C, Song J, Lin X, Dou R, Bai J, Xiang Z, Huang S, Liu K, Xiong B
Cell communication and signaling : CCS 2020 Mar 30;18(1):51
Cell communication and signaling : CCS 2020 Mar 30;18(1):51
Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation.
Du QH, Zhang CJ, Li WH, Mu Y, Xu Y, Lowe S, Han L, Yu X, Wang SY, Li Y, Li J
World journal of gastroenterology 2020 Jun 7;26(21):2810-2820
World journal of gastroenterology 2020 Jun 7;26(21):2810-2820
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity.
Wang H, Cai J, Du S, Wei W, Shen X
Experimental cell research 2020 Jun 1;391(1):111984
Experimental cell research 2020 Jun 1;391(1):111984
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196
International journal of oncology 2020 Jul;57(1):183-196
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage.
Yuan C, Dai C, Li Z, Zheng L, Zhao M, Dong S
Neurochemical research 2020 Jul;45(7):1500-1509
Neurochemical research 2020 Jul;45(7):1500-1509
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Song J, Liu L, Lv L, Hu S, Tariq A, Wang W, Dang X
Cell biology international 2020 Jul;44(7):1491-1502
Cell biology international 2020 Jul;44(7):1491-1502
Activation of BDNF/TrkB pathway promotes prostate cancer progression via induction of epithelial-mesenchymal transition and anoikis resistance.
Li T, Yu Y, Song Y, Li X, Lan D, Zhang P, Xiao Y, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9087-9101
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9087-9101
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
Hu C, Xia H, Bai S, Zhao J, Edwards H, Li X, Yang Y, Lyu J, Wang G, Zhan Y, Dong Y, Ge Y
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
AMPK decreases ERK1/2 activity and cancer cell sensitivity to nutrition deprivation by mediating a positive feedback loop involving eEF2K.
Tong S, Zhou T, Meng Y, Xu D, Chen J
Oncology letters 2020 Jul;20(1):61-66
Oncology letters 2020 Jul;20(1):61-66
Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury.
Pang H, Wang N, Chai J, Wang X, Zhang Y, Bi Z, Wu W, He G
European journal of medicinal chemistry 2020 Jul 1;197:112314
European journal of medicinal chemistry 2020 Jul 1;197:112314
Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy.
Xu D, Liu J, Ma H, Guo W, Wang J, Kan X, Li Y, Gong Q, Cao Y, Cheng J, Fu S
International immunopharmacology 2020 Jan;78:105983
International immunopharmacology 2020 Jan;78:105983
Spondin 2 promotes the proliferation, migration and invasion of gastric cancer cells.
Lu H, Feng Y, Hu Y, Guo Y, Liu Y, Mao Q, Xue W
Journal of cellular and molecular medicine 2020 Jan;24(1):98-113
Journal of cellular and molecular medicine 2020 Jan;24(1):98-113
Programmed cell death protein 1 promotes hepatitis B virus transmission through the regulation of ERK1/2-mediated trophoblasts differentiation.
Yang J, Liu J, Sheng M, Zhang X, Liu M
Archives of gynecology and obstetrics 2020 Feb;301(2):551-558
Archives of gynecology and obstetrics 2020 Feb;301(2):551-558
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response.
Li G, Wang G, Wang S, Sun M, Wen Z
Antonie van Leeuwenhoek 2020 Feb;113(2):303-310
Antonie van Leeuwenhoek 2020 Feb;113(2):303-310
PP2A alleviates oxidized LDL-induced endothelial dysfunction by regulating LOX-1/ROS/MAPK axis.
Xu K, Liu X, Yin D, Ren G, Zhao Y
Life sciences 2020 Feb 15;243:117270
Life sciences 2020 Feb 15;243:117270
Benzoylaconitine Inhibits Production of IL-6 and IL-8 via MAPK, Akt, NF-κB Signaling in IL-1β-Induced Human Synovial Cells.
Yu HH, Li M, Li YB, Lei BB, Yuan X, Xing XK, Xie YF, Wang M, Wang L, Yang HJ, Feng ZW, Cheng BF
Biological & pharmaceutical bulletin 2020 Feb 1;43(2):334-339
Biological & pharmaceutical bulletin 2020 Feb 1;43(2):334-339
Hepatoprotective effect of Xiayuxue decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells.
Zhang D, Zhang L, Chen G, Xu Y, Yang H, Xiao Z, Chen J, Mu Y, Zhang H, Liu W, Liu P
Pharmaceutical biology 2020 Dec;58(1):1229-1243
Pharmaceutical biology 2020 Dec;58(1):1229-1243
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis.
Kong F, Li N, Tu T, Tao Y, Bi Y, Yuan D, Zhang N, Yang X, Kong D, You H, Zheng K, Tang R
Laboratory investigation; a journal of technical methods and pathology 2020 Dec;100(12):1602-1617
Laboratory investigation; a journal of technical methods and pathology 2020 Dec;100(12):1602-1617
MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling.
Qin WY, Feng SC, Sun YQ, Jiang GQ
The journal of gene medicine 2020 Aug;22(8):e3188
The journal of gene medicine 2020 Aug;22(8):e3188
Correcting abnormalities in miR-124/PTPN1 signaling rescues tau pathology in Alzheimer's disease.
Hou TY, Zhou Y, Zhu LS, Wang X, Pang P, Wang DQ, Liuyang ZY, Man H, Lu Y, Zhu LQ, Liu D
Journal of neurochemistry 2020 Aug;154(4):441-457
Journal of neurochemistry 2020 Aug;154(4):441-457
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.
Li JM, Yang F, Li J, Yuan WQ, Wang H, Luo YQ
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
Medical science monitor : international medical journal of experimental and clinical research 2020 Aug 7;26:e925298
IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.
Wang M, Guo J, Zhao YQ, Wang JP
Aging 2020 Aug 28;12(16):16099-16110
Aging 2020 Aug 28;12(16):16099-16110
Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-κB or Nonactivating CREB/BDNF in Mouse Hippocampus.
Wu L, Liu X, Huang Y, Lu C, Zhou J, Ren P, Huang X
ACS chemical neuroscience 2020 Aug 19;11(16):2472-2481
ACS chemical neuroscience 2020 Aug 19;11(16):2472-2481
Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.
Liu X, Zhou C, Li Y, Deng Y, Lu W, Li J
Gene 2020 Aug 15;751:144726
Gene 2020 Aug 15;751:144726
Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21(Waf1) signalling pathway.
Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, Shen X
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
Biochemistry and cell biology = Biochimie et biologie cellulaire 2020 Apr;98(2):191-202
Calcium-sensing receptor promotes tumor proliferation and migration in human intrahepatic cholangiocarcinoma by targeting ERK signaling pathway.
Fang Y, Liu L, Liu S, Hu L, Cai W, Wan X, Liu D, He Y, Zhu Z
European journal of pharmacology 2020 Apr 5;872:172915
European journal of pharmacology 2020 Apr 5;872:172915
Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways.
Yu ZY, Jiang XY, Zhao RR, Qin JJ, Luo CJ, Ren YX, Ren W, Ma ZJ, Jiao ZY
Chinese medical journal 2020 Apr 20;133(8):919-928
Chinese medical journal 2020 Apr 20;133(8):919-928
Identification of RE1-Silencing Transcription Factor as a Promoter of Metastasis in Pancreatic Cancer.
Jin H, Liu P, Kong L, Fei X, Gao Y, Wu T, Sun D, Tan X
Frontiers in oncology 2019;9:291
Frontiers in oncology 2019;9:291
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Wang G, Xu B, Shi F, Du M, Li Y, Yu T, Chen L
Oxidative medicine and cellular longevity 2019;2019:7850324
Oxidative medicine and cellular longevity 2019;2019:7850324
Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis.
Li L, Jiang H, Wei X, Geng D, He M, Du H
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3949824
Evidence-based complementary and alternative medicine : eCAM 2019;2019:3949824
Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma.
Chen H, Liu J, Wang H, Cheng Q, Zhou C, Chen X, Ye F
Journal of Cancer 2019;10(6):1580-1592
Journal of Cancer 2019;10(6):1580-1592
Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.
Tang G, Zeng Z, Sun W, Li S, You C, Tang F, Peng S, Ma S, Luo Y, Xu J, Tian X, Zhang N, Gong Y, Xie C
Journal of Cancer 2019;10(10):2261-2275
Journal of Cancer 2019;10(10):2261-2275
Hedyotis diffusa Willd. inhibits VEGF‑C‑mediated lymphangiogenesis in colorectal cancer via multiple signaling pathways.
Li H, Lai Z, Yang H, Peng J, Chen Y, Lin J
Oncology reports 2019 Sep;42(3):1225-1236
Oncology reports 2019 Sep;42(3):1225-1236
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Regulation of circadian rhythms by NEAT1 mediated TMAO-induced endothelial proliferation: A protective role of asparagus extract.
Wu X, Chen L, Zeb F, Huang Y, An J, Ren J, Yang F, Feng Q
Experimental cell research 2019 Sep 1;382(1):111451
Experimental cell research 2019 Sep 1;382(1):111451
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
Wang K, Zhu TN, Zhao RJ
Molecular medicine reports 2019 Oct;20(4):3671-3678
Molecular medicine reports 2019 Oct;20(4):3671-3678
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK(½)/mTOR signaling pathways in oral squamous cell carcinomas.
Gao L, Dou ZC, Ren WH, Li SM, Liang X, Zhi KQ
Cell death & disease 2019 Oct 3;10(10):745
Cell death & disease 2019 Oct 3;10(10):745
CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Xu W, Hua H, Chiu YH, Li G, Zhi H, Yu Z, Ren F, Luo Y, Cui W
Cell reports 2019 Oct 29;29(5):1311-1322.e5
Cell reports 2019 Oct 29;29(5):1311-1322.e5
Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.
Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, Liu Y, Zhang J
Journal of physiology and biochemistry 2019 Nov;75(4):549-559
Journal of physiology and biochemistry 2019 Nov;75(4):549-559
MicroRNA‑186‑5p mediates osteoblastic differentiation and cell viability by targeting CXCL13 in non‑traumatic osteonecrosis.
Xu W, Li J, Tian H, Wang R, Feng Y, Tang J, Jia J
Molecular medicine reports 2019 Nov;20(5):4594-4602
Molecular medicine reports 2019 Nov;20(5):4594-4602
MicroRNA-125a-3p affects smooth muscle cell function in vascular stenosis.
Hu W, Chang G, Zhang M, Li Y, Yin L, Huang Y, Feng C, Gu Y, Wen D, Wang S
Journal of molecular and cellular cardiology 2019 Nov;136:85-94
Journal of molecular and cellular cardiology 2019 Nov;136:85-94
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Liu K, Lu R, Zhao Q, Du J, Li Y, Zheng M, Zhang S
Medical oncology (Northwood, London, England) 2019 Nov 16;37(1):6
Medical oncology (Northwood, London, England) 2019 Nov 16;37(1):6
PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.
Ma Q, Gu JT, Wang B, Feng J, Yang L, Kang XW, Duan P, Sun X, Liu PJ, Wang JC
European journal of pharmacology 2019 Nov 15;863:172696
European journal of pharmacology 2019 Nov 15;863:172696
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Wang G, Zhao L, Lin H, Wang Y, Taub JW, Ge Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Yin B, Hou XW, Lu ML
Acta pharmacologica Sinica 2019 May;40(5):599-607
Acta pharmacologica Sinica 2019 May;40(5):599-607
Transcriptional Study Revealed That Boron Supplementation May Alter the Immune-Related Genes Through MAPK Signaling in Ostrich Chick Thymus.
Xiao K, Yang K, Wang J, Sun P, Huang H, Khaliq H, Naeem MA, Zhong J, Peng K
Biological trace element research 2019 May;189(1):209-223
Biological trace element research 2019 May;189(1):209-223
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Yang F, Lin ZW, Huang TY, Chen TT, Cui J, Li MY, Hua YQ
Scientific reports 2019 May 6;9(1):6991
Scientific reports 2019 May 6;9(1):6991
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.
Yang H, Liu JX, Shang HX, Lin S, Zhao JY, Lin JM
World journal of gastrointestinal oncology 2019 May 15;11(5):377-392
World journal of gastrointestinal oncology 2019 May 15;11(5):377-392
Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway.
Wu YJ, Su TR, Dai GF, Su JH, Liu CI
Marine drugs 2019 May 13;17(5)
Marine drugs 2019 May 13;17(5)
Proteomic Profiles of the Early Mitochondrial Changes in APP/PS1 and ApoE4 Transgenic Mice Models of Alzheimer's Disease.
He K, Nie L, Zhou Q, Rahman SU, Liu J, Yang X, Li S
Journal of proteome research 2019 Jun 7;18(6):2632-2642
Journal of proteome research 2019 Jun 7;18(6):2632-2642
Elucidating dosage-effect relationship of different efficacy of rhubarb in constipation model rats by factor analysis.
Chen JQ, Li DW, Chen YY, Tao HJ, Pu ZJ, Zhang J, Tan YJ, Shi XQ, Yue SJ, Zhou GS, Tang YP, Duan JA
Journal of ethnopharmacology 2019 Jun 28;238:111868
Journal of ethnopharmacology 2019 Jun 28;238:111868
Aryl hydrocarbon receptor activation alleviates dextran sodium sulfate-induced colitis through enhancing the differentiation of goblet cells.
Yin J, Yang K, Zhou C, Xu P, Xiao W, Yang H
Biochemical and biophysical research communications 2019 Jun 18;514(1):180-186
Biochemical and biophysical research communications 2019 Jun 18;514(1):180-186
Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.
Zhang C, Huang H, Zhang J, Wu Q, Chen X, Huang T, Li W, Liu Y, Zhang J
Cell death & disease 2019 Jun 17;10(7):477
Cell death & disease 2019 Jun 17;10(7):477
Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects.
Shi A, Heinayati A, Bao D, Liu H, Ding X, Tong X, Wang L, Wang B, Qin H
Stem cell research & therapy 2019 Jun 13;10(1):172
Stem cell research & therapy 2019 Jun 13;10(1):172
Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-κB Pathways.
Zhong KL, Lu MY, Liu F, Mei Y, Zhang XJ, Zhang H, Zan J, Sun XO, Tan W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jan;28(1):175-184
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jan;28(1):175-184
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Sun J, Ren XS, Kang Y, Dai HB, Ding L, Tong N, Zhu GQ, Zhou YB
Neuroscience bulletin 2019 Feb;35(1):34-46
Neuroscience bulletin 2019 Feb;35(1):34-46
Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis.
Luo H, Han Y, Liu J, Zhang Y
Gene 2019 Feb 20;686:250-260
Gene 2019 Feb 20;686:250-260
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
Aging cell 2019 Dec;18(6):e13027
Aging cell 2019 Dec;18(6):e13027
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
Zhu B, Ren C, Du K, Zhu H, Ai Y, Kang F, Luo Y, Liu W, Wang L, Xu Y, Jiang X, Zhang Y
Biochemical pharmacology 2019 Dec;170:113642
Biochemical pharmacology 2019 Dec;170:113642
Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo.
Wang L, Huang W, Zhan J
Nutrients 2019 Dec 6;11(12)
Nutrients 2019 Dec 6;11(12)
Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury.
Su L, Jiang X, Yang C, Zhang J, Chen B, Li Y, Yao S, Xie Q, Gomez H, Murugan R, Peng Z
The Journal of biological chemistry 2019 Dec 13;294(50):19395-19404
The Journal of biological chemistry 2019 Dec 13;294(50):19395-19404
Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma.
Zeng C, Xing W, Liu Y
Journal of cellular biochemistry 2019 Aug;120(8):12489-12499
Journal of cellular biochemistry 2019 Aug;120(8):12489-12499
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
Liu NW, Huang X, Liu S, Lu Y
Medical science monitor : international medical journal of experimental and clinical research 2019 Aug 29;25:6491-6503
Medical science monitor : international medical journal of experimental and clinical research 2019 Aug 29;25:6491-6503
Intermedin in Paraventricular Nucleus Attenuates Ang II-Induced Sympathoexcitation through the Inhibition of NADPH Oxidase-Dependent ROS Generation in Obese Rats with Hypertension.
Kang Y, Ding L, Dai H, Wang F, Zhou H, Gao Q, Xiong X, Zhang F, Song T, Yuan Y, Zhu G, Zhou Y
International journal of molecular sciences 2019 Aug 28;20(17)
International journal of molecular sciences 2019 Aug 28;20(17)
Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation.
Li G, Shen X, Wei Y, Si X, Deng X, Wang J
International immunopharmacology 2019 Apr;69:71-78
International immunopharmacology 2019 Apr;69:71-78
Treatment with MQA, a Derivative of Caffeoylquinic Acid, Provides Neuroprotective Effects against Cerebral Ischemia Through Suppression of the p38 Pathway and Oxidative Stress in Rats.
Chen L, Liu DN, Wang Y, Liu XY, Han S, Zhang K, Li GY, Tian X, Wang HY, Wang JH
Journal of molecular neuroscience : MN 2019 Apr;67(4):604-612
Journal of molecular neuroscience : MN 2019 Apr;67(4):604-612
Carnosine improves diabetic retinopathy via the MAPK/ERK pathway.
Guo Y, Guo C, Ha W, Ding Z
Experimental and therapeutic medicine 2019 Apr;17(4):2641-2647
Experimental and therapeutic medicine 2019 Apr;17(4):2641-2647
GLRX inhibition enhances the effects of geftinib in EGFR-TKI-resistant NSCLC cells through FoxM1 signaling pathway.
Wang L, Liu J, Liu J, Chen X, Chang M, Li J, Zhou J, Bai C, Song Y
Journal of cancer research and clinical oncology 2019 Apr;145(4):861-872
Journal of cancer research and clinical oncology 2019 Apr;145(4):861-872
Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy.
Sun CY, Nie J, Zheng ZL, Zhao J, Wu LM, Zhu Y, Su ZQ, Zheng GJ, Feng B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108647
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108647
TMEM30A deficiency in endothelial cells impairs cell proliferation and angiogenesis.
Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, Yang M, Zhang L, Zhu X
Journal of cell science 2019 Apr 3;132(7)
Journal of cell science 2019 Apr 3;132(7)
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Ren D, Zhao Y, Zheng Q, Alim A, Yang X
Food & function 2019 Apr 1;10(4):2186-2197
Food & function 2019 Apr 1;10(4):2186-2197
An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid.
Wang LC, Wei WH, Zhang XW, Liu D, Zeng KW, Tu PF
Frontiers in pharmacology 2018;9:370
Frontiers in pharmacology 2018;9:370
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction.
Ye C, Zhang C, Huang H, Yang B, Xiao G, Kong D, Tian Q, Song Q, Song Y, Tan H, Wang Y, Zhou T, Zi X, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(3):1230-1244
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Tang Y, Huang W, Song Q, Zheng X, He R, Liu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.
Chen T, Zhu H, Wang Y, Zhao P, Chen J, Sun J, Zhang X, Zhu G
American journal of translational research 2018;10(8):2555-2566
American journal of translational research 2018;10(8):2555-2566
Axis of serotonin -pERK-YAP in liver regeneration.
Fang Y, Liu C, Shu B, Zhai M, Deng C, He C, Luo M, Han T, Zheng W, Zhang J, Liu S
Life sciences 2018 Sep 15;209:490-497
Life sciences 2018 Sep 15;209:490-497
2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis.
Lin CY, Chin YT, Kuo PJ, Lee HW, Huang HM, Lin HY, Weng IT, Hsiung CN, Chan YH, Lee SY
International endodontic journal 2018 Oct;51(10):1159-1170
International endodontic journal 2018 Oct;51(10):1159-1170
IL-8 analogue CXCL8 (3-72) K11R/G31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK1/2-AP-1 pathways in THP-1 monocytes.
Walana W, Wang JJ, Yabasin IB, Ntim M, Kampo S, Al-Azab M, Elkhider A, Dogkotenge Kuugbee E, Cheng JW, Gordon JR, Li F
Human immunology 2018 Nov;79(11):809-816
Human immunology 2018 Nov;79(11):809-816
Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma.
Li H, Zhang M, Linghu E, Zhou F, Herman JG, Hu L, Guo M
Clinical epigenetics 2018 Nov 6;10(1):137
Clinical epigenetics 2018 Nov 6;10(1):137
Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway.
Fang Y, Liu G, Xie C, Qian K, Lei X, Liu Q, Liu G, Cao Z, Fu J, Du H, Liu S, Huang S, Hu J, Xu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 May;101:910-919
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 May;101:910-919
Inhibition of transient receptor potential melastatin 8 alleviates airway inflammation and remodeling in a murine model of asthma with cold air stimulus.
Liu H, Liu Q, Hua L, Pan J
Acta biochimica et biophysica Sinica 2018 May 1;50(5):499-506
Acta biochimica et biophysica Sinica 2018 May 1;50(5):499-506
Effects of gelling bath on the physical properties of alginate gel beads and the biological characteristics of entrapped HepG2 cells.
Sun D, Liu Y, Wu H, Ren Y, Ma X, Wu H, Sun G
Biotechnology and applied biochemistry 2018 Mar;65(2):263-273
Biotechnology and applied biochemistry 2018 Mar;65(2):263-273
Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen-Glucose Deprivation and Reperfusion.
Zhao P, Chang RY, Liu N, Wang J, Zhou R, Qi X, Liu Y, Ma L, Niu Y, Sun T, Li YX, He YP, Yu JQ
Cellular and molecular neurobiology 2018 Mar;38(2):529-540
Cellular and molecular neurobiology 2018 Mar;38(2):529-540
Down-regulation of GADD45A enhances chemosensitivity in melanoma.
Liu J, Jiang G, Mao P, Zhang J, Zhang L, Liu L, Wang J, Owusu L, Ren B, Tang Y, Li W
Scientific reports 2018 Mar 7;8(1):4111
Scientific reports 2018 Mar 7;8(1):4111
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Liu Y, Wang T, Liu X, Wen Y, Xu T, Yu X, Wei X, Ding X, Mo L, Yin M, Tan X, Chen L
Journal of neuroinflammation 2018 Mar 22;15(1):92
Journal of neuroinflammation 2018 Mar 22;15(1):92
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells.
Li H, Fu X, Gao Y, Li X, Shen Y, Wang W
Journal of bone oncology 2018 Jun;11:17-22
Journal of bone oncology 2018 Jun;11:17-22
Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in hepatocellular carcinoma.
Lin J, Cao S, Wang Y, Hu Y, Liu H, Li J, Chen J, Li P, Liu J, Wang Q, Zheng L
Journal of experimental & clinical cancer research : CR 2018 Jun 4;37(1):113
Journal of experimental & clinical cancer research : CR 2018 Jun 4;37(1):113
NF-κB and JNK mediated apoptosis and G(0)/G(1) arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis.
Zeng GZ, Wang Z, Zhao LM, Fan JT, Tan NH
Journal of ethnopharmacology 2018 Jun 28;220:220-227
Journal of ethnopharmacology 2018 Jun 28;220:220-227
Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties.
Wang S, Xu M, Li X, Su X, Xiao X, Keating A, Zhao RC
Journal of hematology & oncology 2018 Jun 14;11(1):82
Journal of hematology & oncology 2018 Jun 14;11(1):82
Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis.
Jin X, Li F, Liu B, Zheng X, Li H, Ye F, Chen W, Li Q
Biochemical and biophysical research communications 2018 Jun 12;500(4):958-965
Biochemical and biophysical research communications 2018 Jun 12;500(4):958-965
Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway.
Jin B, Jin H
Experimental animals 2018 Jul 30;67(3):337-347
Experimental animals 2018 Jul 30;67(3):337-347
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Zhang J, Liu L, Wang J, Ren B, Zhang L, Li W
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, Liu M
International journal of molecular sciences 2018 Jul 12;19(7)
International journal of molecular sciences 2018 Jul 12;19(7)
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, He C, Zheng C, Li K, Ma X, Xiang G
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.
Wang Y, Gao H, Wu T, Wang Z, Song F, Chen A, Zhang J, Zhang W, Zhang H, Yu J
Oncology letters 2018 Jan;15(1):863-870
Oncology letters 2018 Jan;15(1):863-870
Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury.
Zhao L, Li D, Liu N, Liu L, Zhang Z, Gao C, Kawano H, Zhou FY, Li HP
Molecular pain 2018 Jan-Dec;14:1744806918796057
Molecular pain 2018 Jan-Dec;14:1744806918796057
Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer.
Zhang S, Xiao J, Chai Y, Hong Z, Liu Z, Yuan R, Luo Z, Zhou X, Lucero-Prisno DE III, Huang K
Digestive diseases and sciences 2018 Feb;63(2):395-402
Digestive diseases and sciences 2018 Feb;63(2):395-402
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Su Y, Li X, Ma J, Zhao J, Liu S, Wang G, Edwards H, Taub JW, Lin H, Ge Y
Biochemical pharmacology 2018 Feb;148:13-26
Biochemical pharmacology 2018 Feb;148:13-26
Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease.
Roe AJ, Qi X
Biochemical and biophysical research communications 2018 Feb 5;496(2):706-711
Biochemical and biophysical research communications 2018 Feb 5;496(2):706-711
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Li J, Liu H, Yang Z, Zhou F, Wei T, Dong Y, Xue H, Tang L, Liu M
International journal of molecular sciences 2018 Feb 3;19(2)
International journal of molecular sciences 2018 Feb 3;19(2)
Modulation of IGF1R Signaling Pathway by GIGYF1 in High Glucose-Induced SHSY-5Y Cells.
Zhou T, Ma Y, Tang J, Guo F, Dong M, Wei Q
DNA and cell biology 2018 Dec;37(12):1044-1054
DNA and cell biology 2018 Dec;37(12):1044-1054
Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells.
Li X, Wu J, Zhang X, Chen W
Free radical biology & medicine 2018 Dec;129:256-267
Free radical biology & medicine 2018 Dec;129:256-267
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
Zhang TT, Qu N, Sun GH, Zhang L, Wang YJ, Mu XM, Wei WJ, Wang YL, Wang Y, Ji QH, Zhu YX, Shi RL
International journal of oncology 2018 Aug;53(2):685-693
International journal of oncology 2018 Aug;53(2):685-693
AAED1 modulates proliferation and glycolysis in gastric cancer.
Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y
Oncology reports 2018 Aug;40(2):1156-1164
Oncology reports 2018 Aug;40(2):1156-1164
Cold atmospheric plasma conveys selectivity on triple negative breast cancer cells both in vitro and in vivo.
Xiang L, Xu X, Zhang S, Cai D, Dai X
Free radical biology & medicine 2018 Aug 20;124:205-213
Free radical biology & medicine 2018 Aug 20;124:205-213
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
Interleukin-25 enhances the capacity of mesenchymal stem cells to induce intestinal epithelial cell regeneration.
Su J, Xie C, Fan Y, Cheng W, Hu Y, Huang Q, Shi H, Wang L, Ren J
American journal of translational research 2017;9(12):5320-5331
American journal of translational research 2017;9(12):5320-5331
Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
Yin L, Qi Y, Xu Y, Xu L, Han X, Tao X, Song S, Peng J
Frontiers in pharmacology 2017;8:665
Frontiers in pharmacology 2017;8:665
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors.
Yamaguchi M, Saito SY, Nishiyama R, Nakamura M, Todoroki K, Toyo'oka T, Ishikawa T
Biological & pharmaceutical bulletin 2017;40(5):658-664
Biological & pharmaceutical bulletin 2017;40(5):658-664
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X
International journal of biological sciences 2017;13(3):327-338
International journal of biological sciences 2017;13(3):327-338
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
Chen HB, Luo CD, Liang JL, Zhang ZB, Lin GS, Wu JZ, Li CL, Tan LH, Yang XB, Su ZR, Xie JH, Zeng HF
European journal of pharmacology 2017 Sep 15;811:222-231
European journal of pharmacology 2017 Sep 15;811:222-231
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions.
Han Y, Luo H, Wang H, Cai J, Zhang Y
Apoptosis : an international journal on programmed cell death 2017 Oct;22(10):1260-1272
Apoptosis : an international journal on programmed cell death 2017 Oct;22(10):1260-1272
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, Song Y, Li S, Wu X, Yang S, Yang C
Experimental cell research 2017 Oct 1;359(1):39-49
Experimental cell research 2017 Oct 1;359(1):39-49
Spiroplasma eriocheiris induces mouse 3T6-Swiss albino cell apoptosis that associated with the infection mechanism.
Hou L, Gu W, Zhu H, Yao W, Wang W, Meng Q
Molecular immunology 2017 Nov;91:75-85
Molecular immunology 2017 Nov;91:75-85
Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.
Peng Z, Gong X, Yang Y, Huang L, Zhang Q, Zhang P, Wan R, Zhang B
International immunopharmacology 2017 Nov;52:281-289
International immunopharmacology 2017 Nov;52:281-289
Polyaniline promotes peripheral nerve regeneration by enhancement of the brain‑derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway.
Fan L, Xiong Y, Fu Z, Xu D, Wang L, Chen Y, Xia H, Peng N, Ye S, Wang Y, Zhang L, Ye Q
Molecular medicine reports 2017 Nov;16(5):7534-7540
Molecular medicine reports 2017 Nov;16(5):7534-7540
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, Li J, Li S, Wu L, Feng J, Wang W, Lu X, Liu T, Wang F, Dai W, Fan X, Mo W, Xu L, Guo C
Scientific reports 2017 Nov 9;7(1):15175
Scientific reports 2017 Nov 9;7(1):15175
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells.
Yin K, Zhu R, Wang S, Zhao RC
Stem cells and development 2017 May 15;26(10):762-775
Stem cells and development 2017 May 15;26(10):762-775
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Ren D, Lin D, Alim A, Zheng Q, Yang X
Food & function 2017 Mar 22;8(3):1299-1312
Food & function 2017 Mar 22;8(3):1299-1312
Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways.
Chen X, Luo Y, Huang Z, Jia G, Liu G, Zhao H
Scientific reports 2017 Mar 22;7:45156
Scientific reports 2017 Mar 22;7:45156
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Xie XC, Zhao N, Xu QH, Yang X, Xia WK, Chen Q, Wang M, Fei X
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, Polin L, Dyson G, Taub JW, Mohammad RM, Azmi AS, Zhao L, Ge Y
Oncotarget 2017 Jul 4;8(27):44295-44311
Oncotarget 2017 Jul 4;8(27):44295-44311
ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation.
Peng U, Wang Z, Pei S, Ou Y, Hu P, Liu W, Song J
Oncology reports 2017 Feb;37(2):1270-1276
Oncology reports 2017 Feb;37(2):1270-1276
Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Yan Z, Feng J, Peng J, Lai Z, Zhang L, Jin Y, Yang H, Chen W, Lin J
Oncology letters 2017 Dec;14(6):7923-7930
Oncology letters 2017 Dec;14(6):7923-7930
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Ma Y, Jiang J, Zhang Y, Ding Y, Xu T, Lu B
Molecular medicine reports 2017 Aug;16(2):1445-1450
Molecular medicine reports 2017 Aug;16(2):1445-1450
Vascular protective effects of aqueous extracts of Tribulus terrestris on hypertensive endothelial injury.
Jiang YH, Guo JH, Wu S, Yang CH
Chinese journal of natural medicines 2017 Aug;15(8):606-614
Chinese journal of natural medicines 2017 Aug;15(8):606-614
Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway.
Zhao X, Zhao G, Shi Z, Zhou C, Chen Y, Hu B, Yan S
Scientific reports 2017 Apr 5;7:45779
Scientific reports 2017 Apr 5;7:45779
The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
Fu J, Xia X, Liu Z, Wang Y, Wang Y, Shi Q, Song X, Song E, Song Y
Toxicology 2017 Apr 15;381:39-50
Toxicology 2017 Apr 15;381:39-50
Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway.
Wang D, Wang D, Wang N, Long Z, Ren X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(3-4):644-656
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(3-4):644-656
Hypoxia regulates ABCG2 activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells.
He X, Wang J, Wei W, Shi M, Xin B, Zhang T, Shen X
Cancer biology & therapy 2016;17(2):188-98
Cancer biology & therapy 2016;17(2):188-98
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, Wang Y
BMC microbiology 2016 Sep 23;16(1):222
BMC microbiology 2016 Sep 23;16(1):222
Original Research: Atorvastatin prevents rat cardiomyocyte hypertrophy induced by parathyroid hormone 1-34 associated with the Ras-ERK signaling.
Liu X, Zou C, Yu C, Xie R, Sui M, Mu S, Li L, Zhao S
Experimental biology and medicine (Maywood, N.J.) 2016 Oct;241(16):1745-50
Experimental biology and medicine (Maywood, N.J.) 2016 Oct;241(16):1745-50
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition.
Hu Y, Tao X, Han X, Xu L, Yin L, Qi Y, Zhao Y, Xu Y, Wang C, Peng J
Chemico-biological interactions 2016 Oct 25;258:234-44
Chemico-biological interactions 2016 Oct 25;258:234-44
Charaterization and immunomodulatory activities of polysaccharide isolated from Pleurotus eryngii.
Xu D, Wang H, Zheng W, Gao Y, Wang M, Zhang Y, Gao Q
International journal of biological macromolecules 2016 Nov;92:30-36
International journal of biological macromolecules 2016 Nov;92:30-36
Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer.
Xin B, He X, Wang J, Cai J, Wei W, Zhang T, Shen X
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2016 Nov-Dec;16(6):1005-1014
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2016 Nov-Dec;16(6):1005-1014
HDAC6-mediated EGFR stabilization and activation restrict cell response to sorafenib in non-small cell lung cancer cells.
Wang Z, Hu P, Tang F, Xie C
Medical oncology (Northwood, London, England) 2016 May;33(5):50
Medical oncology (Northwood, London, England) 2016 May;33(5):50
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
Wang N, Cao Y, Zhu Y
Molecular medicine reports 2016 Mar;13(3):2175-81
Molecular medicine reports 2016 Mar;13(3):2175-81
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Wang D, Wang M, Jiang N, Zhang Y, Bian X, Wang X, Roberts TM, Zhao JJ, Liu P, Cheng H
Oncotarget 2016 Mar 15;7(11):13153-66
Oncotarget 2016 Mar 15;7(11):13153-66
ELISA-PLA: A novel hybrid platform for the rapid, highly sensitive and specific quantification of proteins and post-translational modifications.
Tong QH, Tao T, Xie LQ, Lu HJ
Biosensors & bioelectronics 2016 Jun 15;80:385-391
Biosensors & bioelectronics 2016 Jun 15;80:385-391
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, Xie C
Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.
Wu X, Liu W, Duan Z, Gao Y, Li S, Wang K, Song Y, Shao Z, Yang S, Yang C
Scientific reports 2016 Jul 27;6:30563
Scientific reports 2016 Jul 27;6:30563
ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner.
Liu X, Ren K, Suo R, Xiong SL, Zhang QH, Mo ZC, Tang ZL, Jiang Y, Peng XS, Yi GH
Journal of physiology and biochemistry 2016 Dec;72(4):657-667
Journal of physiology and biochemistry 2016 Dec;72(4):657-667
The role of STIM1 in the Cr(vi)-induced [Ca(2+)](i) increase and cell injury in L-02 hepatocytes.
Yi X, Zhang Y, Zhong C, Zhong X, Xiao F
Metallomics : integrated biometal science 2016 Dec 7;8(12):1273-1282
Metallomics : integrated biometal science 2016 Dec 7;8(12):1273-1282
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma.
Wang Z, Hu P, Tang F, Lian H, Chen X, Zhang Y, He X, Liu W, Xie C
Cancer letters 2016 Aug 28;379(1):134-42
Cancer letters 2016 Aug 28;379(1):134-42
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Zhang L, Liu L, He X, Shen Y, Liu X, Wei J, Yu F, Tian J
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
Dong F, Ling Q, Ye D, Zhang Z, Shu J, Chen G, Fei Y, Li C
Scientific reports 2016 Apr 25;6:24859
Scientific reports 2016 Apr 25;6:24859
Famitinib enhances nasopharyngeal cancer cell radiosensitivity by attenuating radiation-induced phosphorylation of platelet-derived growth factor receptor and c-kit and inhibiting microvessel formation.
Mu X, Ma J, Zhang Z, Zhou H, Xu S, Qin Y, Huang J, Yang K, Wu G
International journal of radiation biology 2015;91(9):771-6
International journal of radiation biology 2015;91(9):771-6
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92
Oncotarget 2015 Oct 13;6(31):32177-92
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinib.
Li Z, Yang SS, Yin PH, Chang T, Shi LX, Fang L, Fang GE
Thoracic cancer 2015 Nov;6(6):695-703
Thoracic cancer 2015 Nov;6(6):695-703
Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion.
Xie Y, Cui D, Sui L, Xu Y, Zhang N, Ma Y, Li Y, Kong Y
Cell and tissue research 2015 Nov;362(2):421-30
Cell and tissue research 2015 Nov;362(2):421-30
The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination.
Morgan JE, Shanderson RL, Boyd NH, Cacan E, Greer SF
Bioscience reports 2015 Jun 19;35(4)
Bioscience reports 2015 Jun 19;35(4)
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis.
Chen K, He H, Xie Y, Zhao L, Zhao S, Wan X, Yang W, Mo Z
Scientific reports 2015 Jul 7;5:11909
Scientific reports 2015 Jul 7;5:11909
Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.
Huang P, Li C, Fu T, Zhao D, Yi Z, Lu Q, Guo L, Xu X
Behavioural brain research 2015 Jul 15;288:1-10
Behavioural brain research 2015 Jul 15;288:1-10
Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.
Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW
International journal of oncology 2015 Apr;46(4):1667-76
International journal of oncology 2015 Apr;46(4):1667-76
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Zhao L, Teng B, Wen L, Feng Q, Wang H, Li N, Wang Y, Liang Z
International journal of clinical and experimental medicine 2014;7(2):337-47
International journal of clinical and experimental medicine 2014;7(2):337-47
Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.
Wang CP, Li GC, Shi YW, Zhang XC, Li JL, Wang ZW, Ding F, Liang XM
Journal of physiology and biochemistry 2014 Sep;70(3):735-47
Journal of physiology and biochemistry 2014 Sep;70(3):735-47
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y, Bai X
Oncogene 2014 Sep 11;33(37):4548-57
Oncogene 2014 Sep 11;33(37):4548-57
Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion.
Wang CP, Zhang LZ, Li GC, Shi YW, Li JL, Zhang XC, Wang ZW, Ding F, Liang XM
Journal of neuroscience research 2014 Jul;92(7):944-54
Journal of neuroscience research 2014 Jul;92(7):944-54
Inhibition of melanogenesis by gallic acid: possible involvement of the PI3K/Akt, MEK/ERK and Wnt/β-catenin signaling pathways in B16F10 cells.
Su TR, Lin JJ, Tsai CC, Huang TK, Yang ZY, Wu MO, Zheng YQ, Su CC, Wu YJ
International journal of molecular sciences 2013 Oct 14;14(10):20443-58
International journal of molecular sciences 2013 Oct 14;14(10):20443-58
Isoquercetin protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via suppression of TLR4-NF-кB signal pathway.
Wang CP, Li JL, Zhang LZ, Zhang XC, Yu S, Liang XM, Ding F, Wang ZW
Neurochemistry international 2013 Dec;63(8):741-9
Neurochemistry international 2013 Dec;63(8):741-9
Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells.
Neoh CA, Wang RY, Din ZH, Su JH, Chen YK, Tsai FJ, Weng SH, Wu YJ
Marine drugs 2012 Dec 18;10(12):2893-911
Marine drugs 2012 Dec 18;10(12):2893-911
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 16443-1-AP(ERK1/2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16443-1-AP(ERK1/2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ERK1/2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ERK1/2. This antibody recognizes human,mouse,rat,zebrafish antigen. The ERK1/2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
