51068-1-AP

antibody from Proteintech Group

Targeting: MAPK1 ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2

Provider product page for 51068-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [32]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 51068-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#51068-1-AP, RRID:AB_2250380
Product name: ERK1/2 antibody
Antibody type: Polyclonal
Description: ERK1/2 antibody (Cat. #51068-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAPK1 protein structure - 51068-1-AP shown in red.

Submitted references Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.

Han T, Wang Y, Cheng M, Hu Q, Wan X, Huang M, Liu Y, Xun W, Xu J, Wang L, Luo R, Yuan Y, Wang K, Wang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(18):e2307834

Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.

Zhang M, Zhang J, Hu H, Zhou Y, Lin Z, Jing H, Sun B
Journal of translational medicine 2024 Jun 27;22(1):598

ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability.

Huang R, Sun Y, Liu R, Zhu B, Zhang H, Wu H
Journal of ethnopharmacology 2024 Jun 12;327:117969

Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer.

Peng Y, Lei X, Yang Q, Zhang G, He S, Wang M, Ling R, Zheng B, He J, Chen X, Li F, Zhou Q, Zhao L, Ye G, Li G
Experimental & molecular medicine 2024 Feb;56(2):441-452

Network pharmacology, molecular docking and experimental study of CEP in nasopharyngeal carcinoma.

Yang J, Qin L, Zhou S, Li J, Tu Y, Mo M, Liu X, Huang J, Qin X, Jiao A, Wei W, Yang P
Journal of ethnopharmacology 2024 Apr 6;323:117667

Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.

Yang C, Wang X, To KKW, Cui C, Luo M, Wu S, Huang L, Fu K, Pan C, Liu Z, Fan T, Yang C, Wang F, Fu L
Signal transduction and targeted therapy 2024 Apr 5;9(1):84

Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.

Wang X, Fu Y, Yang X, Chen Y, Zeng N, Hu S, Ouyang S, Pan X, Wu S
Scientific reports 2024 Apr 27;14(1):9723

FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.

Wang R, Huang W, Cai K, Xiao S, Zhang W, Hu X, Guo J, Mao L, Yuan W, Xu Y, Chen Z, Chen Z, Lai C
International journal of biological sciences 2023;19(16):5104-5119

USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1.

Zhang H, Han Y, Xiao W, Gao Y, Sui Z, Ren P, Meng F, Tang P, Yu Z
Cell death & disease 2023 Nov 10;14(11):730

Silica nanoparticles induce pulmonary damage in rats via VEGFC/D-VEGFR3 signaling-mediated lymphangiogenesis and remodeling.

Yu Y, Pan Y, Chang B, Zhao X, Qu K, Song Y
Toxicology 2023 Jul;493:153552

Low Pi stress enhances the sensitivity of hepatocellular carcinoma to sorafenib.

Bi QC, Deng ZQ, Lv YF, Liu Y, Xie CS, He YQ, Tang Q
Biochemical pharmacology 2023 Jul;213:115593

Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism.

Qin H, Zhuang W, Liu X, Wu J, Li S, Wang Y, Liu X, Chen C, Zhang H
Cell reports 2023 Jul 25;42(7):112745

Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.

Shen C, Chen Z, Zhang Y, Xu W, Peng R, Jiang J, Zuo W, Fan Y, Zheng B
Oncology reports 2023 Jan;49(1)

Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.

Zuo R, Shi J, Jiang S, Chu M, Wang Q, Kong L, Kang Q, Guo Y, Guan J
International journal of biological macromolecules 2023 Jan 31;226:900-914

Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.

Zhang Z, Zhu Z, Fu J, Liu X, Mi Z, Tao H, Fan H
International immunopharmacology 2023 Feb;115:109684

ETV6 Regulates Hemin-Induced Erythroid Differentiation of K562 Cells through Mediating the Raf/MEK/ERK Pathway.

Li Z, Sun MZ, Lv X, Guo C, Liu S
Biological & pharmaceutical bulletin 2022;45(3):250-259

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.

He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274

Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.

Wang H, Cui Y, Gong H, Xu J, Huang S, Tang A
Frontiers in bioengineering and biotechnology 2022;10:929979

Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation.

Zhu H, Zhang L, Jia H, Xu L, Cao Y, Zhai M, Li K, Xia L, Jiang L, Li X, Zhou Y, Liu J, Yu S, Duan W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154283

Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.

Ma Y, Li S, Ye S, Hu D, Luo S, Wei L, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Oct;168:113354

Tangeretin prevents cognitive deficit in delirium through activating RORα/γ-E4BP4 axis in mice.

Chen M, Xiao Y, Zhang F, Du J, Zhang L, Li Y, Lu D, Wang Z, Wu B
Biochemical pharmacology 2022 Nov;205:115286

Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo.

Fang Y, Zhong T, Yang L, Luo F, Li Q, Wang D, Li Q, Fan Y, Yang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154151

Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.

Yang X, Shang P, Ji J, Malichewe C, Yao Z, Liao J, Du D, Sun C, Wang L, Tang YJ, Guo X
Molecular pharmaceutics 2022 Jan 3;19(1):2-17

Guifu Dihuang Pills Ameliorated Mucus Hypersecretion by Suppressing Muc5ac Expression and Inactivating the ERK-SP1 Pathway in Lipopolysaccharide/Cigarette Smoke-Induced Mice.

Zhang H, Yu W, Ji L, Zhong Y, Lin Y, Ying H, Yu C, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9539218

Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.

Li L, Wang J, Feng L, Fan J, Wang J, Tan N, Wang Z
Journal of ethnopharmacology 2021 Sep 15;277:114184

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.

Duquenne M, Folgueira C, Bourouh C, Millet M, Silva A, Clasadonte J, Imbernon M, Fernandois D, Martinez-Corral I, Kusumakshi S, Caron E, Rasika S, Deliglia E, Jouy N, Oishi A, Mazzone M, Trinquet E, Tavernier J, Kim YB, Ory S, Jockers R, Schwaninger M, Boehm U, Nogueiras R, Annicotte JS, Gasman S, Dam J, Prévot V
Nature metabolism 2021 Aug;3(8):1071-1090

The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation.

Fan YH, Ding HW, Kim D, Liu JY, Hong JY, Xu YN, Wang D, Yang XS, Lee SK
Pharmacological research 2020 Oct;160:105147

Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.

Tong X, Liang R, Jia Y, Qin W, Guo C, Wu X, Wang Z, Chen D, Tan N
Frontiers in pharmacology 2019;10:1422

Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.

Tateyama H, Murase Y, Higuchi H, Inasaka Y, Kaneoka H, Iijima S, Nishijima KI
Immunology 2019 Dec;158(4):340-352

Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.

Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729

Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis.

Bao YN, Cao X, Luo DH, Sun R, Peng LX, Wang L, Yan YP, Zheng LS, Xie P, Cao Y, Liang YY, Zheng FJ, Huang BJ, Xiang YQ, Lv X, Chen QY, Chen MY, Huang PY, Guo L, Mai HQ, Guo X, Zeng YX, Qian CN
Cell cycle (Georgetown, Tex.) 2014;13(12):1958-69

A systems biology-based classifier for hepatocellular carcinoma diagnosis.

Zhang Y, Wang S, Li D, Zhnag J, Gu D, Zhu Y, He F
PloS one 2011;6(7):e22426

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 51068-1-AP(ERK1/2 antibody) at dilution of 1:3000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ERK1/2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ERK1/2. This antibody recognizes human, mouse, rat antigen. The ERK1/2 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 51068-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 51068-1-AP(ERK1/2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human cervical cancer using 51068-1-AP(ERK1/2 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue