Antibody data
- Antibody Data
- Antigen structure
- References [63]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 51068-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#51068-1-AP, RRID:AB_2250380
- Product name
- ERK1/2 antibody
- Antibody type
- Polyclonal
- Description
- ERK1/2 antibody (Cat. #51068-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
Active components and mechanisms of Shuganning injection in lessening acetaminophen-induced acute liver injury.
Zinc-doped carbon dots from natural Isatis Indigotica folium and calamine: SOD/CAT-mimetic activity targets ROS-Ca²⁺-NLRP3 axis for psoriatic dermatitis therapy.
Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation.
Mechanism of silica nanoparticles induced pulmonary epithelial-mesenchymal transition mediated by exosomal HNRNPAB.
Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone.
TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1.
Role of ELP6 in tumour progression and impact on ERK1/2 signalling pathway inhibitors in skin cutaneous melanoma.
Nootkatone Alleviates Type 2 Diabetes in db/db Mice Through AMPK Activation and ERK Inhibition: An Integrated In Vitro and In Vivo Study.
Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfusion injury.
Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.
Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis.
Synthetic short mRNA prevents metastasis via innate-adaptive immunity.
Optogenetic control of biomolecular organization reveals distinct roles of phase separation in RTK signaling.
Proteomic analysis of isolated nerve terminals from Na V 1.9 knockout mice reveals pathways relevant for pain perception.
Bufalin inhibits hepatocellular carcinoma progression by blocking EGFR-mediated RAS-RAF-MEK-ERK pathway activation.
CBX2 as a therapeutic target in colorectal cancer: insights into the altered chromatin accessibility via RUNX1-CBX2-MAP4K1 axis.
P24 Loaded Gelatin-Hydroxyapatite-Tricalcium Phosphate Scaffold Induces Bone Regeneration by Activating the ERK/ELK1/PLA2G3 Pathway.
Integrated network pharmacology, proteomics, molecular docking, and experiments in vivo and in vitro to explore the efficacy and potential mechanism of bufalin against hepatocellular carcinoma angiogenesis.
Investigating the anti-cancer potential of sulfatase 1 and its underlying mechanism in non-small cell lung cancer.
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest.
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis.
2,5-Dihydroxyacetophenone attenuates acute kidney injury induced by intra-abdominal infection in rats.
Duck circovirus regulates the expression of duck CLDN2 protein by activating the MAPK-ERK pathway to affect its adhesion and infection.
Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus.
Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition.
Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.
ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability.
Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer.
NRF3 suppresses the malignant progression of TNBC by promoting M1 polarization of macrophages via ROS/HMGB1 axis.
Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway.
TFAP2A drives non-small cell lung cancer (NSCLC) progression and resistance to targeted therapy by facilitating the ESR2-mediated MAPK pathway.
Network pharmacology, molecular docking and experimental study of CEP in nasopharyngeal carcinoma.
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.
USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1.
Silica nanoparticles induce pulmonary damage in rats via VEGFC/D-VEGFR3 signaling-mediated lymphangiogenesis and remodeling.
Low Pi stress enhances the sensitivity of hepatocellular carcinoma to sorafenib.
Targeting CXCR1 alleviates hyperoxia-induced lung injury through promoting glutamine metabolism.
Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.
Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma.
Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway.
ETV6 Regulates Hemin-Induced Erythroid Differentiation of K562 Cells through Mediating the Raf/MEK/ERK Pathway.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.
Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation.
Effect of propiconazole on neutrophil extracellular traps formation: Assessing the role of autophagy.
Tangeretin prevents cognitive deficit in delirium through activating RORα/γ-E4BP4 axis in mice.
Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo.
Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.
The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAF(V600E) mutation contributes to tumorigenesis and development of glioblastoma.
Guifu Dihuang Pills Ameliorated Mucus Hypersecretion by Suppressing Muc5ac Expression and Inactivating the ERK-SP1 Pathway in Lipopolysaccharide/Cigarette Smoke-Induced Mice.
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation.
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.
Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis.
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Frontiers in bioengineering and biotechnology 2022;10:929979
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Biochemical pharmacology 2022 Nov;205:115286
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Molecular pharmaceutics 2022 Jan 3;19(1):2-17
The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAF(V600E) mutation contributes to tumorigenesis and development of glioblastoma.
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Biochemical and biophysical research communications 2022 Jan 15;588:1-7
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Evidence-based complementary and alternative medicine : eCAM 2021;2021:9539218
Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.
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Journal of ethnopharmacology 2021 Sep 15;277:114184
Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
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Nature metabolism 2021 Aug;3(8):1071-1090
The PI3Kα inhibitor DFX24 suppresses tumor growth and metastasis in non-small cell lung cancer via ERK inhibition and EPHB6 reactivation.
Fan YH, Ding HW, Kim D, Liu JY, Hong JY, Xu YN, Wang D, Yang XS, Lee SK
Pharmacological research 2020 Oct;160:105147
Pharmacological research 2020 Oct;160:105147
Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.
Tong X, Liang R, Jia Y, Qin W, Guo C, Wu X, Wang Z, Chen D, Tan N
Frontiers in pharmacology 2019;10:1422
Frontiers in pharmacology 2019;10:1422
Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Tateyama H, Murase Y, Higuchi H, Inasaka Y, Kaneoka H, Iijima S, Nishijima KI
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Immunology 2019 Dec;158(4):340-352
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729
Molecular medicine reports 2018 Jun;17(6):7721-7729
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 51068-1-AP(ERK1/2 antibody) at dilution of 1:3000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The ERK1/2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human ERK1/2. This antibody recognizes human, mouse, rat antigen. The ERK1/2 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 51068-1-AP(ERK1/2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 51068-1-AP(ERK1/2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue