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- Antibody Data
- Antigen structure
- References [87]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 12834-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12834-1-AP, RRID:AB_10597094
- Product name
- HDAC6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC6 antibody (Cat. #12834-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.
THBS1 upregulation by KLF7 in hypopharyngeal squamous cell carcinoma contributes to lung metastasis through the p38 MAPK signaling.
Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer's patient-derived cortical neurons.
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
African swine fever virus DEAD-box helicase D1133L promotes OGG1-driven incision of genomic 8-oxoG via HDAC5 deacetylation.
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction.
CTB alleviated premature ovarian insufficiency induced by cigarette smoke exposure in mice through activating CREB1 by P300-mediated histone acetylation modifications.
Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function.
The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer.
The Leupaxin/HDAC6/EGR2 axis facilitates breast cancer progression by enhancing macrophage M2 polarization.
HDAC6 facilitates LUAD progression by inducing EMT and enhancing macrophage polarization towards the M2 phenotype.
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency.
Formin INF2 supplementation alleviates cytoskeleton-based mitochondria defects for oocyte quality under obesity.
Sall1 regulates microtubule acetylation in mesenchymal cells during mouse urethral development.
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms.
A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice.
Multi-omics integrated analysis to generate transcriptome and protome profiles of resveratrol improving Paraquat-induced acute lung injury.
Human HDAC6 senses valine abundancy to regulate DNA damage.
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models.
Comprehensive analysis of angiogenesis and stemness-related genes in chemotherapy and immunotherapy of bladder cancer.
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
ACY1215 Exerts Anti-inflammatory Effects by Inhibition of NF-κB and STAT3 Signaling Pathway to Repair Spinal Cord Injury.
Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial-Stromal Interplay in Cancer Development.
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation.
Insufficient KIF15 during porcine oocyte ageing induces HDAC6-based microtubule instability.
Effects of a novel HDAC6-selective inhibitor's radiosensitization on cancer cells.
Primary cilia suppress the fibrotic activity of atrial fibroblasts from patients with atrial fibrillation in vitro.
Local delivery of EGFR(+)NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway.
Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Repeated (S)-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota-brain axis.
Design, synthesis, and biological evaluation of novel AAK1/HDACs dual inhibitors against SARS-CoV-2 entry.
Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders.
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.
Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development.
Histone deacetylase 6 suppression of renal tubular epithelial cell promotes interstitial mineral deposition via alpha-tubulin acetylation.
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
LIPUS accelerates bone regeneration via HDAC6-mediated ciliogenesis.
FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
HDAC6 inhibition regulates substrate stiffness-mediated inflammation signaling in chondrocytes.
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
HDAC6 Triggers the ATM-Dependent DNA Damage Response To Promote PRV Replication.
Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells.
HDAC6 Inhibition Alleviates Anesthesia and Surgery-Induced Less Medial Prefrontal-Dorsal Hippocampus Connectivity and Cognitive Impairment in Aged Rats.
Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells.
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.
Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation.
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of Osteoarthritis via Improving Mitochondrial Function.
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.
RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication.
hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells.
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.
An Interaction Landscape of Ubiquitin Signaling.
Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang G, Gong G, Yang X, Qian Y, Zhao Y, Li D, Liu M, Xu Z, Zhang F
Journal of advanced research 2026 Mar 9;
Journal of advanced research 2026 Mar 9;
THBS1 upregulation by KLF7 in hypopharyngeal squamous cell carcinoma contributes to lung metastasis through the p38 MAPK signaling.
Cheng H, Tang D, Hu S, Zhang Z, Wang W
iScience 2026 Mar 20;29(3):114816
iScience 2026 Mar 20;29(3):114816
Elevated SGK1 increases Tau phosphorylation and microtubule instability in Alzheimer's patient-derived cortical neurons.
Saleem K, Xiao Z, Zhu B, Ren Y, Yan Z, Feng J
Molecular psychiatry 2026 Jan;31(1):332-342
Molecular psychiatry 2026 Jan;31(1):332-342
HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-β/SMAD and CSF1R signaling.
Jiang Y, Yu J, Wang T, Du Q, Wang J, Lu Y, Xu Q, Liu H, Li X, Tong L, Qin T, Huang D
Molecular cancer 2026 Jan 7;25(1):33
Molecular cancer 2026 Jan 7;25(1):33
African swine fever virus DEAD-box helicase D1133L promotes OGG1-driven incision of genomic 8-oxoG via HDAC5 deacetylation.
Fan J, Yang J, Tian Z, Zhang X, Geng S, Luo J, Boldogh I, Zeng Q, Yin H, Guan G, Niu Q
Journal of molecular cell biology 2026 Feb 13;17(7)
Journal of molecular cell biology 2026 Feb 13;17(7)
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction.
Jin Q, Chen C, Wu P, Li L, Jiang L, Chen R, Xu S, Huang Y, Xu H, Long X
Cell biology and toxicology 2026 Feb 12;42(1)
Cell biology and toxicology 2026 Feb 12;42(1)
CTB alleviated premature ovarian insufficiency induced by cigarette smoke exposure in mice through activating CREB1 by P300-mediated histone acetylation modifications.
Hu N, Xin N, Wang Y, Liu D, Zhao Y, Xu M, Li F, Miao J, Ji S, Wang L
Ecotoxicology and environmental safety 2025 Sep 1;302:118625
Ecotoxicology and environmental safety 2025 Sep 1;302:118625
Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function.
Peng X, Zhou P, Zhang K, Chen L, Tang M, Zhou Q, Peng J, Yang L
Cell death & disease 2025 Oct 21;16(1):743
Cell death & disease 2025 Oct 21;16(1):743
The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer.
Shang T, Jiang T, Tan J, Jiang H, Xu M, Pan Y, Lin Y, Cui X, Tian C, Feng H, Chen Y, Pei M, Geng X, Cheng S, Tan Y, Wang H, Dong L
Signal transduction and targeted therapy 2025 Oct 14;10(1):341
Signal transduction and targeted therapy 2025 Oct 14;10(1):341
The Leupaxin/HDAC6/EGR2 axis facilitates breast cancer progression by enhancing macrophage M2 polarization.
He S, Wang Q, He J, Chen Z, Xiao Y
Cell biology and toxicology 2025 Nov 25;41(1):154
Cell biology and toxicology 2025 Nov 25;41(1):154
HDAC6 facilitates LUAD progression by inducing EMT and enhancing macrophage polarization towards the M2 phenotype.
Jiang Y, Zhang J, Yu J, Luo W, Du Q, Liu W, Xu Q, Li X, Liu H, Huang D, Qin T
NPJ precision oncology 2025 May 22;9(1):150
NPJ precision oncology 2025 May 22;9(1):150
FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation.
Xiao D, Ran H, Chen L, Li Y, Cai Y, Zhang S, Qi Q, Wu H, Zhang C, Cao S, Mi L, Huang H, Qi J, Han Q, Tu H, Li H, Zhou T, Li F, Li A, Man J
Science China. Life sciences 2025 Mar;68(3):673-688
Science China. Life sciences 2025 Mar;68(3):673-688
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
Sun H, Yang C, Yin X, Chen S, Huang Y, Kuang H, Luo W
Scientific reports 2025 Mar 4;15(1):7563
Scientific reports 2025 Mar 4;15(1):7563
IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency.
Ghosh A, Britto J, Chandran B, Roy A
Journal of virology 2025 Mar 18;99(3):e0154924
Journal of virology 2025 Mar 18;99(3):e0154924
Formin INF2 supplementation alleviates cytoskeleton-based mitochondria defects for oocyte quality under obesity.
Zhang HL, Pan ZN, Ju JQ, Ji YM, Wang Y, Sun SC
Free radical biology & medicine 2025 Jun;233:250-263
Free radical biology & medicine 2025 Jun;233:250-263
Sall1 regulates microtubule acetylation in mesenchymal cells during mouse urethral development.
Acebedo AR, Yamada G, Alcantara MC, Raga DD, Sato T, Nishinakamura R, Suzuki K
Cells & development 2025 Jun;182:204027
Cells & development 2025 Jun;182:204027
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms.
Yang F, He Z, Pan X, Xie S, Liang X, Geng L, Xu W, Gong S
Cell communication and signaling : CCS 2025 Jun 4;23(1):263
Cell communication and signaling : CCS 2025 Jun 4;23(1):263
A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice.
Cao A, Li Y, Feng Y, Wang X, Wei W, Sun H, Quan J
Molecules (Basel, Switzerland) 2025 Jul 31;30(15)
Molecules (Basel, Switzerland) 2025 Jul 31;30(15)
Multi-omics integrated analysis to generate transcriptome and protome profiles of resveratrol improving Paraquat-induced acute lung injury.
Xu Z, Huang L, Yu Z, Gao Y, Wang R, Du B, Cui X, Yuan J
Ecotoxicology and environmental safety 2025 Jul 15;300:118459
Ecotoxicology and environmental safety 2025 Jul 15;300:118459
Human HDAC6 senses valine abundancy to regulate DNA damage.
Jin J, Meng T, Yu Y, Wu S, Jiao CC, Song S, Li YX, Zhang Y, Zhao YY, Li X, Wang Z, Liu YF, Huang R, Qin J, Chen Y, Cao H, Tan X, Ge X, Jiang C, Xue J, Yuan J, Wu D, Wu W, Jiang CZ, Wang P
Nature 2025 Jan;637(8044):215-223
Nature 2025 Jan;637(8044):215-223
Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation.
Fang R, Bai L, Verheijen BM, Li B, Dong K, Paulo JA, Zhou M, Chu YC, Song Y, Sherman MY, Gygi S, Field CM, Mitchison TJ, Lu Y
Nature communications 2025 Aug 22;16(1):7852
Nature communications 2025 Aug 22;16(1):7852
Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models.
Fang M, Luo L, Chen Y, Liu Y, Yan Y, Wang F, Zou Y, Zhu H, Wu X, Jin Z, Huang C, Zhang Y, Fan S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2412152
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2412152
Comprehensive analysis of angiogenesis and stemness-related genes in chemotherapy and immunotherapy of bladder cancer.
Yin ZX, Qiu Y, Xu C, Pei C
Biomolecules & biomedicine 2025 Apr 18;25(10):2209-2228
Biomolecules & biomedicine 2025 Apr 18;25(10):2209-2228
Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.
Benedetti R, Di Crosta M, Gilardini Montani MS, D'Orazi G, Cirone M
Cell death discovery 2025 Apr 10;11(1):162
Cell death discovery 2025 Apr 10;11(1):162
ACY1215 Exerts Anti-inflammatory Effects by Inhibition of NF-κB and STAT3 Signaling Pathway to Repair Spinal Cord Injury.
Dai C, Wang X, Liu R, Gao W, Zhang H, Yin Z, Ding Z
Biological & pharmaceutical bulletin 2024;47(10):1734-1745
Biological & pharmaceutical bulletin 2024;47(10):1734-1745
Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial-Stromal Interplay in Cancer Development.
Karunasagara S, Taghizadeh A, Kim SH, Kim SJ, Kim YJ, Taghizadeh M, Kim MY, Oh KY, Lee JH, Kim HS, Hyun J, Kim HW
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2400063
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2400063
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation.
Sun S, Xu Z, He L, Shen Y, Yan Y, Lv X, Zhu X, Li W, Tian WY, Zheng Y, Lin S, Sun Y, Li L
Nature communications 2024 Sep 27;15(1):8377
Nature communications 2024 Sep 27;15(1):8377
Insufficient KIF15 during porcine oocyte ageing induces HDAC6-based microtubule instability.
Yin YX, Ding MQ, Yi Y, Zou YJ, Liao BY, Sun SC
Theriogenology 2024 Sep 15;226:49-56
Theriogenology 2024 Sep 15;226:49-56
Effects of a novel HDAC6-selective inhibitor's radiosensitization on cancer cells.
Hu H, Wang Q, Zhang Y, Yang S, Shen A, Yan J, Zhao D, Hu B
Molecular biology reports 2024 Nov 13;51(1):1151
Molecular biology reports 2024 Nov 13;51(1):1151
Primary cilia suppress the fibrotic activity of atrial fibroblasts from patients with atrial fibrillation in vitro.
Kawasaki M, Al-Shama RFM, Nariswari FA, Fabrizi B, van den Berg NWE, Wesselink R, Neefs J, Meulendijks ER, Baalman SWE, Driessen AHG, de Groot JR
Scientific reports 2024 May 30;14(1):12470
Scientific reports 2024 May 30;14(1):12470
Local delivery of EGFR(+)NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway.
Qin T, Li C, Xu Y, Qin Y, Jin Y, He R, Luo Z, Zhao J, Duan C, Lu H, Cao Y, Hu J
Bioactive materials 2024 Mar;33:424-443
Bioactive materials 2024 Mar;33:424-443
Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.
Wu C, Pan Y, Wang L, Liu M, Tu P, Chen S, Shi L, Yan D, Ma Y, Guo Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14439
CNS neuroscience & therapeutics 2024 Mar;30(3):e14439
Shift work promotes adipogenesis via cortisol-dependent downregulation of EGR3-HDAC6 pathway.
Wan X, Wang L, Khan MA, Peng L, Zhang K, Sun X, Yi X, Wang Z, Chen K
Cell death discovery 2024 Mar 11;10(1):129
Cell death discovery 2024 Mar 11;10(1):129
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
Repeated (S)-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota-brain axis.
Jiang Y, Wang X, Chen J, Zhang Y, Hashimoto K, Yang JJ, Zhou Z
Gut microbes 2024 Jan-Dec;16(1):2310603
Gut microbes 2024 Jan-Dec;16(1):2310603
Design, synthesis, and biological evaluation of novel AAK1/HDACs dual inhibitors against SARS-CoV-2 entry.
Mao ND, Xu Y, Yao X, Gao Y, Hui Z, Che H, Wang C, Lu J, Yu J, Hu S, Zhang H, Ye XY
Bioorganic chemistry 2024 Dec;153:107973
Bioorganic chemistry 2024 Dec;153:107973
Probing class I histone deacetylases (HDAC) with proteolysis targeting chimera (PROTAC) for the development of highly potent and selective degraders.
Ibrahim HS, Guo M, Hilscher S, Erdmann F, Schmidt M, Schutkowski M, Sheng C, Sippl W
Bioorganic chemistry 2024 Dec;153:107887
Bioorganic chemistry 2024 Dec;153:107887
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.
Zhang J, Zhao Y, Liang R, Zhou X, Wang Z, Yang C, Gao L, Zheng Y, Shao H, Su Y, Cui W, Jia L, Yang J, Wu C, Wang L
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5219-5234
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5219-5234
Integrative Analysis of Lactylome and Proteome of Hypertrophic Scar To Identify Pathways or Proteins Associated with Disease Development.
Zhang E, Yan Q, Sun Y, Li J, Chen L, Zou J, Zeng S, Jiang J, Li J
Journal of proteome research 2024 Aug 2;23(8):3367-3382
Journal of proteome research 2024 Aug 2;23(8):3367-3382
Histone deacetylase 6 suppression of renal tubular epithelial cell promotes interstitial mineral deposition via alpha-tubulin acetylation.
Li S, Wu W, Yang B, Liu Z, Duan X, Sun X, Liu H, Zhang S, Zhou Y, Wu W
Cellular signalling 2024 Apr;116:111057
Cellular signalling 2024 Apr;116:111057
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, Zhu Q, Liu X, Wang Y, Pei XH, Xu X, Zhang J, Zhu WG
Nucleic acids research 2023 Sep 22;51(17):9166-9182
Nucleic acids research 2023 Sep 22;51(17):9166-9182
LIPUS accelerates bone regeneration via HDAC6-mediated ciliogenesis.
Xiao H, Yan A, Li M, Wang L, Xiang J
Biochemical and biophysical research communications 2023 Jan 22;641:34-41
Biochemical and biophysical research communications 2023 Jan 22;641:34-41
FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration.
Szewczyk B, Günther R, Japtok J, Frech MJ, Naumann M, Lee HO, Hermann A
Cell reports 2023 Feb 28;42(2):112025
Cell reports 2023 Feb 28;42(2):112025
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
HDAC6 inhibition regulates substrate stiffness-mediated inflammation signaling in chondrocytes.
Zhang Y, Tawiah GK, Zhang Y, Wang X, Wei X, Chen W, Qiao X, Zhang Q
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1987-1998
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1987-1998
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
Liu B, Zhang J, Meng X, Xie SM, Liu F, Chen H, Yao D, Li M, Guo M, Shen H, Zhang X, Xing L
Oncogene 2023 Apr;42(15):1181-1195
Oncogene 2023 Apr;42(15):1181-1195
HDAC6 Triggers the ATM-Dependent DNA Damage Response To Promote PRV Replication.
Xu W, Yan P, Zhou Z, Yao J, Pan H, Jiang L, Bo Z, Ni B, Sun M, Gao S, Huan C
Microbiology spectrum 2023 Apr 13;11(2):e0213222
Microbiology spectrum 2023 Apr 13;11(2):e0213222
Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer's disease.
Martínez-Hernández J, Parato J, Sharma A, Soleilhac JM, Qu X, Tein E, Sproul A, Andrieux A, Goldberg Y, Moutin MJ, Bartolini F, Peris L
Frontiers in cell and developmental biology 2022;10:926914
Frontiers in cell and developmental biology 2022;10:926914
The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.
Yuan S, Huang T, Bao Z, Wang S, Wu X, Liu J, Liu H, Chen ZJ
Genome biology 2022 Sep 6;23(1):187
Genome biology 2022 Sep 6;23(1):187
CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells.
Gong S, Hu G, Guo R, Zhang J, Yang Y, Ji B, Li G, Yao H
Cell regeneration (London, England) 2022 Sep 19;11(1):34
Cell regeneration (London, England) 2022 Sep 19;11(1):34
HDAC6 Inhibition Alleviates Anesthesia and Surgery-Induced Less Medial Prefrontal-Dorsal Hippocampus Connectivity and Cognitive Impairment in Aged Rats.
Chen J, Liu S, Wang X, Huang J, Phillips J, Ma D, Ouyang W, Tong J
Molecular neurobiology 2022 Oct;59(10):6158-6169
Molecular neurobiology 2022 Oct;59(10):6158-6169
Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells.
Wei L, Ma W, Cai H, Peng SP, Tian HB, Wang JF, Gao L, He JP
Biomedical and environmental sciences : BES 2022 May 20;35(5):419-436
Biomedical and environmental sciences : BES 2022 May 20;35(5):419-436
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Feng Y, Ma Z, Pan M, Xu L, Feng J, Zhang Y, Shao C, Guo K, Duan H, Zhang Y, Zhang Y, Zhang J, Lu D, Ren X, Han J, Li X, Yan X
Cell death & disease 2022 May 20;13(5):480
Cell death & disease 2022 May 20;13(5):480
Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.
Shan MM, Zou YJ, Pan ZN, Zhang HL, Xu Y, Ju JQ, Sun SC
Development (Cambridge, England) 2022 Mar 1;149(5)
Development (Cambridge, England) 2022 Mar 1;149(5)
Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.
Zou YJ, Shan MM, Wan X, Liu JC, Zhang KH, Ju JQ, Xing CH, Sun SC
Cellular and molecular life sciences : CMLS 2022 Jul 14;79(8):422
Cellular and molecular life sciences : CMLS 2022 Jul 14;79(8):422
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
Zhang C, Tang Q, Xia H, Xu H, Bi F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22121
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22121
Targeting the lncMST-EPRS/HSP90AB1 complex as novel therapeutic strategy for T-2 toxin-induced growth retardation.
Lu Q, Guo P, Li H, Liu Y, Yuan L, Zhang B, Wu Q, Wang X
Ecotoxicology and environmental safety 2022 Dec 1;247:114243
Ecotoxicology and environmental safety 2022 Dec 1;247:114243
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.
Zhang D, Tang J, Xu Y, Huang X, Wang Y, Jin X, Wu G, Liu P
Cell death & disease 2022 Aug 17;13(8):717
Cell death & disease 2022 Aug 17;13(8):717
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing VEGF Gene Transcription via Enhancing H3K9 Deacetylation by Recruiting HDAC6.
Kai H, Wu Q, Yin R, Tang X, Shi H, Wang T, Zhang M, Pan C
Frontiers in cell and developmental biology 2021;9:701628
Frontiers in cell and developmental biology 2021;9:701628
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis.
Zhang L, Zhang Z, Li C, Zhu T, Gao J, Zhou H, Zheng Y, Chang Q, Wang M, Wu J, Ran L, Wu Y, Miao H, Zou X, Liang B
Cellular and molecular gastroenterology and hepatology 2021;11(3):697-724
Cellular and molecular gastroenterology and hepatology 2021;11(3):697-724
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Yan X, Qu X, Liu B, Zhao Y, Xu L, Yu S, Wang J, Wang L, Su J
Frontiers in oncology 2021;11:742460
Frontiers in oncology 2021;11:742460
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
Gopalan J, Omar MH, Roy A, Cruz NM, Falcone J, Jones KN, Forbush KA, Himmelfarb J, Freedman BS, Scott JD
eLife 2021 Jul 12;10
eLife 2021 Jul 12;10
HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation.
Zhan Y, Wang H, Zhang L, Pei F, Chen Z
Frontiers in cell and developmental biology 2020;8:605609
Frontiers in cell and developmental biology 2020;8:605609
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Zheng Y, Zhu G, Tang Y, Yan J, Han S, Yin J, Peng B, He X, Liu W
Frontiers in microbiology 2020;11:78
Frontiers in microbiology 2020;11:78
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules.
Tang K, Li S, Li P, Xia Q, Yang R, Li T, Li L, Jiang Y, Qin X, Yang H, Wu C, You F, Tan Y, Liu Y
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Biochimica et biophysica acta. Molecular cell research 2020 May;1867(5):118676
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.
Yao Y, Hao F, Tang LC, Xu XH, Jin L
Molecular human reproduction 2020 Jul 1;26(7):521-531
Molecular human reproduction 2020 Jul 1;26(7):521-531
Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury.
Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, Xie L, Wu Y, Xu K, Zhang H, Xiao J
Experimental neurology 2020 Feb;324:113138
Experimental neurology 2020 Feb;324:113138
Inhibition of Histone Deacetylase 6 by Tubastatin A Attenuates the Progress of Osteoarthritis via Improving Mitochondrial Function.
Zheng Y, Chen Y, Lu X, Weng Q, Dai G, Yu Y, Yu K, Gao W
The American journal of pathology 2020 Dec;190(12):2376-2386
The American journal of pathology 2020 Dec;190(12):2376-2386
Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle-Mediated Lysosome-Autophagy System.
Liu J, Kang Y, Yin S, Chen A, Wu J, Liang H, Shao L
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901073
RAB35 depletion affects spindle formation and actin-based spindle migration in mouse oocyte meiosis.
Zhang Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC
Molecular human reproduction 2019 Jul 1;25(7):359-372
Molecular human reproduction 2019 Jul 1;25(7):359-372
Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC
Development (Cambridge, England) 2019 Feb 4;146(3)
Development (Cambridge, England) 2019 Feb 4;146(3)
Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway.
Fu Z, Li F, Jia L, Su S, Wang Y, Cai Z, Xiang M
The Journal of thoracic and cardiovascular surgery 2019 Aug;158(2):408-417.e2
The Journal of thoracic and cardiovascular surgery 2019 Aug;158(2):408-417.e2
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Markmiller S, Fulzele A, Higgins R, Leonard M, Yeo GW, Bennett EJ
Cell reports 2019 Apr 30;27(5):1356-1363.e3
Cell reports 2019 Apr 30;27(5):1356-1363.e3
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Histone deacetylases and acetylated histone H3 are involved in the process of hepatitis B virus DNA replication.
Zhang D, Wang Y, Zhang HY, Jiao FZ, Zhang WB, Wang LW, Zhang H, Gong ZJ
Life sciences 2019 Apr 15;223:1-8
Life sciences 2019 Apr 15;223:1-8
hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells.
Li Z, Liu X, Ma J, Zhang T, Gao X, Liu L
International journal of oncology 2018 Nov;53(5):2200-2212
International journal of oncology 2018 Nov;53(5):2200-2212
Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.
Wobst HJ, Wesolowski SS, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, Deeb TZ, Dunlop J, Brandon NJ, Moss SJ
Frontiers in molecular neuroscience 2017;10:46
Frontiers in molecular neuroscience 2017;10:46
Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.
Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, Lou H, Yan S, Li X, Zhou J, Zhang B
Neuroscience letters 2017 Sep 29;658:114-120
Neuroscience letters 2017 Sep 29;658:114-120
Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells.
Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J, Zhao A, Liu J
British journal of cancer 2017 Mar 28;116(7):903-911
British journal of cancer 2017 Mar 28;116(7):903-911
An Interaction Landscape of Ubiquitin Signaling.
Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M
Molecular cell 2017 Mar 2;65(5):941-955.e8
Molecular cell 2017 Mar 2;65(5):941-955.e8
Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.
Li Q, Ma Y, Zhu Y, Zhang T, Zhou Y
Journal of periodontology 2017 Jan;88(1):e12-e23
Journal of periodontology 2017 Jan;88(1):e12-e23
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, Xie C
Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y, Jin J
International journal of oncology 2015;46(6):2535-45
International journal of oncology 2015;46(6):2535-45
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 12834-1-AP(HDAC6 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HDAC6 (IP:12834-1-AP, 5ug; Detection:12834-1-AP 1:1000) with K-562 cells lysate 11000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 12834-1-AP(HDAC6 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC6. This antibody recognizes human antigen. The HDAC6 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
