10329-1-AP

antibody from Proteintech Group

Targeting: SUMO1 GMP1, OFC10, PIC1, SMT3C, SMT3H3, SUMO-1, UBL1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

10329-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10329-1-AP, RRID:AB_2286872

Product name

SUMO1 antibody

Antibody type

Polyclonal

Description

SUMO1 antibody (Cat. #10329-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

SENP6 Restrains NLRP3 Inflammasome Activation via DeSUMOylation-Driven K48-Linked Ubiquitination of NLRP3 in Acute Lung Injury.

Gu A, Wang B, Zhang Y, Sun C, Wei Y, Yan J, Yang Y, Wang Y, Liu R, Zhang R, Liu J, Gu C, Wang Y
Research (Washington, D.C.) 2026;9:1069

---

SUMO-conjugating enzyme UBE2I inhibition alleviates asthma progression: effects on BHLHE40 and M2 macrophage polarization.

Lin H, Yu S, Li X, Yu L, Chen X, Pang Y, Lv R, Dai B, Zhou Q, Shan L
International immunopharmacology 2026 Jul 1;180:116673

---

HIF1α/PRDX1 axis drives pulmonary vascular remodeling through DRP1 DeSUMOylation and mitochondrial fragmentation.

Wu Y, Liu Y, Shan L, Li X, Wu B, Guo L
Biochimica et biophysica acta. Molecular basis of disease 2026 Feb;1872(2):168094

---

Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity.

Zhao Z, Xu S, Ma J, Zhang Z, Liang S, Guo J
Cardiovascular drugs and therapy 2026 Apr;40(2):447-460

---

SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.

Wang X, Hu G, Shao Y, Dong Z, Liu L, Wang Y, Xie Y, Yu N, Zhu C, Wei F, Jia Y, Wang Y, Cai Q
Theranostics 2025;15(13):6369-6386

---

SUMOylation of ZEB1 Modulates PANoptosis in Burn-Induced Early Acute Kidney Injury.

Zhang J, Huang Z, Lin Q, Zhong H, Hu W, Zhang F, Huang J
Journal of cellular and molecular medicine 2025 Oct;29(20):e70865

---

Antimony exposure induces bladder cancer metastasis via activation of the SUMOylation-dependent TGF-β/Smad2/3 axis.

Yi B, Zhao Z, Gao X, Zhao D, Liu X, Zhang W, Zhang Z, Zhang C
Environmental research 2025 Nov 15;285(Pt 4):122589

---

Modulation of SUMO1-TOP1 DNA damage repair by TOPORS following ovalbumin-induced oxidative stress in macrophages.

Cai X, Xu Q, Yin T, Li X, Cheng Y, Li X, Hao C
Toxicology letters 2025 Jul;410:130-138

---

ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.

Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316

---

Increased SUMO-activating enzyme subunit 1 promotes glycolysis and fibrotic phenotype of diabetic nephropathy.

Wusiman R, Haimiti S, Abuduaini H, Yang M, Wang Y, Gu M, Sailike A, Gao L
Biochemical pharmacology 2025 Jul;237:116920

---

MMP8-mediated vascular remodeling in pulmonary hypertension.

Deng X, You Y, Lv S, Liu Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167582

---

Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 SUMOylation.

Deng Y, Jiang X, Che Z, Shang Y, Hu M, Wang W, Yu W, Yang B, Liu X
Journal of nanobiotechnology 2025 Dec 6;23(1):767

---

Mild microwave hyperthermia promotes mitotic catastrophe, induces time-delayed cGAS-STING activation and restores sensitivity to anti-PDL1 therapy in Pan02 pancreatic cancer model.

Li N, He J, Chen M, Liang S, Zhang C, Pan W, Wang Q, Piao F, Wang R, Yu J, Gong G
Oncoimmunology 2025 Dec 31;14(1):2602216

---

Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL.

Long L, Wu D, Xiong X, Xiong H, Qiu X, Ping S
Cell communication and signaling : CCS 2025 Dec 1;24(1):3

---

Inhibition of HMGN2 SUMOylation ameliorates atherosclerosis by activating PAX5 expression to induce macrophage M2 polarization.

Wang X, Wu P, Shen Y, Xu S, Wan Q, Yang Y
Experimental cell research 2025 Aug 15;451(2):114709

---

SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts.

Martínez-López A, Infante G, Mendiburu-Eliçabe M, Machuca A, Antón OM, González-Fernández M, Luque-García JL, Clarke RB, Castillo-Lluva S
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):437-453

---

SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27.

Wang L, Min J, Qian J, Huang X, Yu X, Cao Y, Sun S, Ke M, Lv X, Su W, Guo M, Li N, Qi S, Huang H, Gu C, Yang Y
Acta pharmaceutica Sinica. B 2025 Apr;15(4):1991-2007

---

SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.

Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006

---

Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization.

Ding X, Zhang X, Cao J, Chen S, Chen Y, Yuan K, Chen B, Yang G, Li S, Yang J, Wang G, Tacke F, Lan T
Cellular and molecular gastroenterology and hepatology 2024;18(6):101406

---

CBX4 suppresses CD8(+) T cell antitumor immunity by reprogramming glycolytic metabolism.

Wang J, Jia W, Zhou X, Ma Z, Liu J, Lan P
Theranostics 2024;14(10):3793-3809

---

Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation.

Jansen LR, Welch MA, Plant LD, Baro DJ
Cell communication and signaling : CCS 2024 Sep 2;22(1):422

---

SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia.

Sun W, Wang J, Liu C, Gao F, Ou Q, Tian H, Xu J, Zhang J, Li J, Xu J, Jia S, Zhang J, Xu G, Huang J, Jin C, Lu L
International journal of biological macromolecules 2024 May;268(Pt 2):131678

---

MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.

Lu J, Zhao Q, Wang L, Li J, Wang H, Lv L, Yuan M, Chen Q, Zhang Z, Luo D, Sheng S, Yuan K, Liu G, Liu M, Shi Y, Guo Y, Dong Z
iScience 2024 Jul 19;27(7):110163

---

Sentrin-specific protease 1 maintains mitochondrial homeostasis through targeting the deSUMOylation of sirtuin-3 to alleviate oxidative damage induced by hepatic ischemia/reperfusion.

Xia K, Guo J, Yu B, Wang T, Qiu Q, Chen Q, Qiu T, Zhou J, Zheng S
Free radical biology & medicine 2024 Jan;210:378-389

---

Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.

Zhao Z, Du JF, Wang QL, Qiu FN, Li P, Jiang Y, Li HJ
Chemical research in toxicology 2024 Jan 15;37(1):57-71

---

SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.

Xu X, Mao Y, Feng Z, Dai F, Gu T, Zheng J
Oncology reports 2024 Feb;51(2)

---

SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1α.

Hui Y, Xia K, Zhong J, Zhang Y, Qiu Q, Chen Z, Wang L, Liu X
Journal of cellular and molecular medicine 2024 Aug;28(16):e70043

---

Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.

Chen X, Yang T, Zhou Y, Mei Z, Zhang W
CNS neuroscience & therapeutics 2024 Apr;30(4):e14725

---

Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma.

Qian L, Liang Z, Wang Z, Wang J, Li X, Zhao J, Li Z, Chen L, Liu Y, Ju Y, Li C, Meng S
Journal of molecular cell biology 2023 Nov 27;15(5)

---

Ubc9 regulates the expression of MHC II in dendritic cells to enhance DSS-induced colitis by mediating RBPJ SUMOylation.

Zhang J, Chen L, Xu Q, Zou Y, Sun F, Zhou Q, Luo X, Li Y, Chen C, Zhang S, Xiong F, Yang P, Liu S, Wang CY
Cell death & disease 2023 Nov 13;14(11):737

---

LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis.

Sun W, Lei X, Lu Q, Wu Q, Ma Q, Huang D, Zhang Y
Pathology, research and practice 2023 Mar;243:154377

---

SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer.

Wu C, Zhu X, Dai Q, Chu Z, Yang S, Dong Z
Frontiers in bioscience (Landmark edition) 2023 Aug 31;28(8):192

---

XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.

Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, Chen J, Luo Y, Guo X, Wei X, Li Y, Zhang Z, Wang D, You F
Science advances 2023 Aug 18;9(33):eadg5211

---

Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation.

Wang H, Wu T, Huang Z, Huang J, Geng Z, Cui B, Yan Y, Zhang Y, Wang Y
The Journal of biological chemistry 2022 Nov;298(11):102599

---

KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.

Liu Y, Tian X, Ke P, Gu J, Ma Y, Guo Y, Xu X, Chen Y, Yang M, Wang X, Xiao F
Neuroscience bulletin 2022 Aug;38(8):841-856

---

Proteomic Profiling Identifies Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Encoded LANA(SIM)-Associated Proteins in Hypoxia.

Liu X, Gan J, Du S, Zhu C, Wang Y, Jia Y, Zhang D, Qu D, Wei F, Robertson ES, Cai Q
mSystems 2021 Dec 21;6(6):e0110921

---

Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability.

Shi R, Wang Y, Gao Y, Xu X, Mao S, Xiao Y, Song S, Wang L, Tian B, Zhao Y, Hua Y, Xu H
American journal of physiology. Cell physiology 2020 Oct 1;319(4):C657-C666

---

Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury.

Wang SJ, Chen H, Tang LJ, Tu H, Liu B, Li NS, Luo XJ, Peng J
Canadian journal of physiology and pharmacology 2020 May;98(5):259-266

---

Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.

Huang S, Wang LL, Xue NN, Li C, Guo HH, Ren TK, Zhan Y, Li WB, Zhang J, Chen XG, Han YX, Zhang JL, Jiang JD
Theranostics 2019;9(23):6745-6763

---

Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.

Ren KD, Liu WN, Tian J, Zhang YY, Peng JJ, Zhang D, Li NS, Yang J, Peng J, Luo XJ
European journal of pharmacology 2019 Oct 15;861:172617

---

SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress.

Xu X, Shi R, Zheng L, Guo Z, Wang L, Zhou M, Zhao Y, Tian B, Truong K, Chen Y, Shen B, Hua Y, Xu H
Journal of molecular cell biology 2018 Oct 1;10(5):460-474

---

SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary.

Cao J, Liu XM, Huang LL, Wang L, Jiao XF, Huo LJ
International journal of molecular medicine 2018 Jun;41(6):3115-3126

---

Sensitive detection of intracellular sumoylation via SNAP tag-mediated translation and RNA polymerase-based amplification.

Yang Y, Zhang CY
Analytical chemistry 2012 Feb 7;84(3):1229-34

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The SUMO1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SUMO1. This antibody recognizes human,mouse,rat antigen. The SUMO1 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

10329-1-AP.pdf

Show more