BS4155

antibody from Bioworld Technology, Inc

Targeting: PDPK1 PDK1

Immunohistochemistry

Antibody data

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Validation data

Product number: BS4155 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS4155, RRID:AB_1663270
Product name: PDK1 (phospho S241) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic phosphopeptide derived from human PDK1 around the phosphorylation site of Serine 241.
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

PDPK1 protein structure - BS4155 shown in red.