Antibody data
- Antibody Data
- Antigen structure
- References [46]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 13730-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13730-1-AP, RRID:AB_2070320
- Product name
- CAMK2 antibody
- Antibody type
- Polyclonal
- Description
- CAMK2 antibody (Cat. #13730-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes.
α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosis.
Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice.
Galangin Overcomes Gefitinib and Sotorasib Resistance in Non-small Cell Lung Cancer by Inhibiting Efferocytosis.
Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways.
Heliox preconditioning exerts pulmonary protection effects on neonatal acute respiratory distress syndrome by inhibiting oxidative stress and apoptosis.
Mechanism of Tourette Syndrome Induced by ABGA-Mediated CaMKII-TH Pathway.
A Novel Mechanism of Chlorogenic Acid in Cardioprotection: Blocking NLRP3 Inflammasome via Ca(2+)/CaMKIIα Signaling in Sepsis-Induced Cardiomyopathy.
Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability.
Dysregulated autophagy, neural signaling pathways and gut-brain axis in a novel vestibular migraine-like rat model: implications for pathogenesis.
Microglial activation drives neuronal dysregulation in alcohol-induced seizure susceptibility.
Targeted suppression of BRD7 with BI-9564 prevents seizure behaviors in pentylenetetrazol and pilocarpine-induced mouse model of epilepsy.
The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion.
Bridging the gap: investigating the role of phosphorylation at the serine 129 site of α-synuclein in VAPB-PTPIP51 interactions.
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Long Non-Coding RNA PVT1 Inhibits Apoptosis Through the miR-30d-5p/CaMKIIδ Axis in Hypoxic-Ischemic Brain Injury.
Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM.
Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability.
Treadmill Exercise Facilitates Synaptic Plasticity in APP/PS1 Mice by Regulating Hippocampal AMPAR Activity.
PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior.
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation.
Merazin hydrate produces rapid antidepressant effects by activating CaMKII to promote neuronal activities and proliferation in hippocampus.
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation.
Nerve Growth Factor/Tyrosine Kinase A Receptor Pathway Enhances Analgesia in an Experimental Mouse Model of Bone Cancer Pain by Increasing Membrane Levels of δ-Opioid Receptors.
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds.
The histone deacetylase inhibitor SAHA exerts a protective effect against myocardial ischemia/reperfusion injury by inhibiting sodium-calcium exchanger.
miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice.
Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models.
Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice.
The Synergistic Cytotoxic Effects of GW5074 and Sorafenib by Impacting Mitochondrial Functions in Human Colorectal Cancer Cell Lines.
Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model.
A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca(2+) Signaling Pathway.
Dysfunction of the Brain-derived Neurotrophic Factor-Tyrosine Kinase B Signaling Pathway Contributes to Learning and Memory Impairments Induced by Neuroinflammation in Mice.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
MORTALIN-Ca(2+) axis drives innate rituximab resistance in diffuse large B-cell lymphoma.
Gold Nanostrip Array-Mediated Wireless Electrical Stimulation for Accelerating Functional Neuronal Differentiation.
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
Chlorogenic Acid Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Wnt Signaling.
MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
Screening and Identification of Differential Ovarian Proteins before and after Induced Ovulation via Seminal Plasma in Bactrian Camels.
MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
TMT-based quantitative proteomic analysis of porcine muscle associated with postmortem meat quality.
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Zhang Q, Zhao N, Wei S, Lu M, Chen K
Frontiers in cardiovascular medicine 2026;13:1670472
Frontiers in cardiovascular medicine 2026;13:1670472
α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosis.
Yue S, Xing H, Du X, Wang Y, Qin R, He J, Yu J, Zhangsun D, Craik DJ, McIntosh JM, Wu Y, Zhu X, Luo S
International journal of biological macromolecules 2026 Mar;349:150933
International journal of biological macromolecules 2026 Mar;349:150933
Whole-brain efferent projections of glutamatergic neurons in the cingulate cortex of mice.
Shi F, Lei L, Qiu J, Zhu Y, Wu H, Wu X
Molecular brain 2026 Mar 16;19(1)
Molecular brain 2026 Mar 16;19(1)
Galangin Overcomes Gefitinib and Sotorasib Resistance in Non-small Cell Lung Cancer by Inhibiting Efferocytosis.
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Journal of agricultural and food chemistry 2026 Apr 29;74(16):12892-12905
Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways.
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Frontiers in pharmacology 2025;16:1730786
Frontiers in pharmacology 2025;16:1730786
Heliox preconditioning exerts pulmonary protection effects on neonatal acute respiratory distress syndrome by inhibiting oxidative stress and apoptosis.
Ma J, Shen L, Shi Y
Frontiers in pharmacology 2025;16:1621190
Frontiers in pharmacology 2025;16:1621190
Mechanism of Tourette Syndrome Induced by ABGA-Mediated CaMKII-TH Pathway.
Wu X, Hao J, Jiang K, Wu M, Zhao X, Zhang X
The journal of gene medicine 2025 Sep;27(9):e70043
The journal of gene medicine 2025 Sep;27(9):e70043
A Novel Mechanism of Chlorogenic Acid in Cardioprotection: Blocking NLRP3 Inflammasome via Ca(2+)/CaMKIIα Signaling in Sepsis-Induced Cardiomyopathy.
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Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability.
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Cell reports 2025 Sep 23;44(9):116217
Cell reports 2025 Sep 23;44(9):116217
Dysregulated autophagy, neural signaling pathways and gut-brain axis in a novel vestibular migraine-like rat model: implications for pathogenesis.
Huang Y, Li H, Chen Q, Yu Q, Zhang C, Shi S, Ren Y, Sun T, Zhai Q, Ban J, Ying C, Pan Y
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The journal of headache and pain 2025 Oct 27;26(1):231
Microglial activation drives neuronal dysregulation in alcohol-induced seizure susceptibility.
Zhang S, Zhou Y, Ren Y, Shang J, Jiang A, Hong Y, Hong S, Wang C, Wang W, Chen J
Scientific reports 2025 Nov 3;15(1):38389
Scientific reports 2025 Nov 3;15(1):38389
Targeted suppression of BRD7 with BI-9564 prevents seizure behaviors in pentylenetetrazol and pilocarpine-induced mouse model of epilepsy.
Chen J, Li Y, Huo X, Huang Z, Li S, Cao W, Zhou C, Xu Y
Behavioural brain research 2025 May 8;485:115549
Behavioural brain research 2025 May 8;485:115549
The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion.
Yang J, Li Z, Li A, Liu Y, Zhang X, Zhang Y, Gao Y
Veterinary research 2025 Feb 7;56(1):33
Veterinary research 2025 Feb 7;56(1):33
Bridging the gap: investigating the role of phosphorylation at the serine 129 site of α-synuclein in VAPB-PTPIP51 interactions.
Liu W, Lu Y, Liu J, Yu Y, Yang H
Acta neuropathologica communications 2025 Feb 24;13(1):40
Acta neuropathologica communications 2025 Feb 24;13(1):40
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
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Nature communications 2025 Feb 18;16(1):1736
Nature communications 2025 Feb 18;16(1):1736
Long Non-Coding RNA PVT1 Inhibits Apoptosis Through the miR-30d-5p/CaMKIIδ Axis in Hypoxic-Ischemic Brain Injury.
Zhao F, Liu J, Xiong Z, Huang L, Zhao Y, Li S, Ying J, Liu Q, Wang S, Su X, Tang J, Qu Y, Mu D
Molecular neurobiology 2025 Dec 8;63(1):268
Molecular neurobiology 2025 Dec 8;63(1):268
Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM.
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Nature communications 2025 Dec 24;16(1):10603
Nature communications 2025 Dec 24;16(1):10603
Modeling Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability.
McCrimmon CM, Toker D, Pahos M, Lozano K, Lin JJ, Parent J, Tidball A, Zheng J, Molnár L, Mody I, Novitch BG, Samarasinghe RA
bioRxiv : the preprint server for biology 2024 Sep 8;
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Treadmill Exercise Facilitates Synaptic Plasticity in APP/PS1 Mice by Regulating Hippocampal AMPAR Activity.
Yu L, Li Y, Lv Y, Gu B, Cai J, Liu QS, Zhao L
Cells 2024 Sep 25;13(19)
Cells 2024 Sep 25;13(19)
PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton, modulating emotional behavior.
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Zoological research 2024 May 18;45(3):535-550
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Sun D, Bian G, Zhang K, Liu N, Yin Y, Hou Y, Xie F, Zhu W, Mao S, Liu J
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Genome biology 2024 Mar 4;25(1):64
Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
Yang Y, Yang C, Shi Y, Tang C, Wang H, Tan M, Xing R, Gao C, Zhang M, Xie Y
The Journal of pharmacy and pharmacology 2024 Jun 1;76(6):736-745
The Journal of pharmacy and pharmacology 2024 Jun 1;76(6):736-745
Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation.
Kopsidas CA, Lowe CC, McDaniel DP, Zhou X, Feng Y
iScience 2024 Jul 19;27(7):110199
iScience 2024 Jul 19;27(7):110199
Merazin hydrate produces rapid antidepressant effects by activating CaMKII to promote neuronal activities and proliferation in hippocampus.
Gao Z, Lu C, Zhu Y, Liu Y, Lin Y, Gao W, Tian L, Wu L
Brain research 2024 Jan 1;1822:148665
Brain research 2024 Jan 1;1822:148665
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation.
Li H, Liuha X, Chen R, Xiao Y, Xu W, Zhou Y, Bai L, Zhang J, Zhao Y, Zhao Y, Wang L, Qin F, Chen Y, Han S, Wei Q, Li S, Zhang D, Bu Q, Wang X, Jiang L, Dai Y, Zhang N, Kuang W, Qin M, Wang H, Tian J, Zhao Y, Cen X
Cell reports 2024 Aug 27;43(8):114529
Cell reports 2024 Aug 27;43(8):114529
Nerve Growth Factor/Tyrosine Kinase A Receptor Pathway Enhances Analgesia in an Experimental Mouse Model of Bone Cancer Pain by Increasing Membrane Levels of δ-Opioid Receptors.
Kan BF, Liu XY, Han MM, Yang CW, Zhu X, Jin Y, Wang D, Huang X, Wu WJ, Fu T, Kang F, Zhang Z, Li J
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Anesthesiology 2024 Apr 1;140(4):765-785
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds.
Chen Y, Qian H, Peng D, Jiang Y, Liu Q, Tan Y, Feng L, Cheng B, Li G
Frontiers in bioengineering and biotechnology 2023;11:1338172
Frontiers in bioengineering and biotechnology 2023;11:1338172
The histone deacetylase inhibitor SAHA exerts a protective effect against myocardial ischemia/reperfusion injury by inhibiting sodium-calcium exchanger.
Shi X, Yin Y, Guo X, Liu M, Ma F, Tian L, Zheng M, Liu G
Biochemical and biophysical research communications 2023 Sep 3;671:105-115
Biochemical and biophysical research communications 2023 Sep 3;671:105-115
miR-26a-5p alleviates CFA-induced chronic inflammatory hyperalgesia through Wnt5a/CaMKII/NFAT signaling in mice.
Lu Y, Liu M, Guo X, Wang P, Zeng F, Wang H, Tang J, Qin Z, Tao T
CNS neuroscience & therapeutics 2023 May;29(5):1254-1271
CNS neuroscience & therapeutics 2023 May;29(5):1254-1271
Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models.
Liu P, Wang C, Chen W, Kang Y, Liu W, Qiu Z, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154594
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154594
Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice.
Guo D, Xu Y, Wang Y, Zhong X, Liu Z, Li S, Xu X, Zhang J, Xiong T, Cao W, Liang J
Behavioural brain research 2023 Feb 15;439:114223
Behavioural brain research 2023 Feb 15;439:114223
The Synergistic Cytotoxic Effects of GW5074 and Sorafenib by Impacting Mitochondrial Functions in Human Colorectal Cancer Cell Lines.
Hu JM, Chang YL, Hsieh CC, Huang SM
Frontiers in oncology 2022;12:925653
Frontiers in oncology 2022;12:925653
Human PMSCs-derived small extracellular vesicles alleviate neuropathic pain through miR-26a-5p/Wnt5a in SNI mice model.
Lu Y, Zhang J, Zeng F, Wang P, Guo X, Wang H, Qin Z, Tao T
Journal of neuroinflammation 2022 Sep 7;19(1):221
Journal of neuroinflammation 2022 Sep 7;19(1):221
A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca(2+) Signaling Pathway.
Liu J, Zhang C, Wang J, Huang Y, Shen D, Hu Y, Chu H, Yu X, Zhang L, Ma H
Pharmaceuticals (Basel, Switzerland) 2022 Nov 28;15(12)
Pharmaceuticals (Basel, Switzerland) 2022 Nov 28;15(12)
Dysfunction of the Brain-derived Neurotrophic Factor-Tyrosine Kinase B Signaling Pathway Contributes to Learning and Memory Impairments Induced by Neuroinflammation in Mice.
Zhang W, Ge MM, Zhang LQ, Yuan XM, Han SY, Manyande A, Tian YK, Tian XB
Neuroscience 2022 Nov 21;505:21-33
Neuroscience 2022 Nov 21;505:21-33
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
MORTALIN-Ca(2+) axis drives innate rituximab resistance in diffuse large B-cell lymphoma.
Sun Q, Ye Y, Gui A, Sun X, Xie S, Zhan Y, Chen R, Yan Y, Gu J, Qiu S, Liu W, Zuo J, Zhang Q, Yang L
Cancer letters 2022 Jul 1;537:215678
Cancer letters 2022 Jul 1;537:215678
Gold Nanostrip Array-Mediated Wireless Electrical Stimulation for Accelerating Functional Neuronal Differentiation.
Yang H, Su Y, Sun Z, Ma B, Liu F, Kong Y, Sun C, Li B, Sang Y, Wang S, Li G, Qiu J, Liu C, Geng Z, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2202376
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2202376
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
Chen X, Wan W, Ran Q, Ye T, Sun Y, Liu Z, Liu X, Shi S, Qu C, Zhang C, Yang B
European journal of pharmacology 2022 Apr 5;920:174799
European journal of pharmacology 2022 Apr 5;920:174799
Chlorogenic Acid Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Wnt Signaling.
Hu X, Wang L, He Y, Wei M, Yan H, Zhu H
Stem cells and development 2021 Jun 15;30(12):641-650
Stem cells and development 2021 Jun 15;30(12):641-650
MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.
Zhao S, Yuan C, Tuo X, Zhou C, Zhao Q, Shen T
Chemosphere 2021 Jan;263:127868
Chemosphere 2021 Jan;263:127868
Screening and Identification of Differential Ovarian Proteins before and after Induced Ovulation via Seminal Plasma in Bactrian Camels.
Wang Q, Zhang Q, Li Y, Zhao X, Zhang Y
Animals : an open access journal from MDPI 2021 Dec 9;11(12)
Animals : an open access journal from MDPI 2021 Dec 9;11(12)
MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via downregulation of synapsin I in rats following chronic cerebral hypoperfusion.
Zhang S, Yan ML, Yang L, An XB, Zhao HM, Xia SN, Jin Z, Huang SY, Qu Y, Ai J
Experimental neurology 2020 Oct;332:113389
Experimental neurology 2020 Oct;332:113389
TMT-based quantitative proteomic analysis of porcine muscle associated with postmortem meat quality.
Hou X, Liu Q, Meng Q, Wang L, Yan H, Zhang L, Wang L
Food chemistry 2020 Oct 30;328:127133
Food chemistry 2020 Oct 30;328:127133
Effects of intrathecal bupivacaine on the NR2B/CaMKIIα/CREB signaling pathway in the rat lumbar spinal cord.
Zhao L, Zhang Y, Yang F, Zhu D, Li N, Zhao L, Li N, Yu J, Ma H
Molecular medicine reports 2018 Mar;17(3):4508-4514
Molecular medicine reports 2018 Mar;17(3):4508-4514
Beneficial Effects of a CaMKIIα Inhibitor TatCN21 Peptide in Global Cerebral Ischemia.
Ahmed ME, Dong Y, Lu Y, Tucker D, Wang R, Zhang Q
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
Journal of molecular neuroscience : MN 2017 Jan;61(1):42-51
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The CaMKII alpha antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CaMKII alpha. This antibody recognizes human,mouse,rat antigen. The CaMKII alpha antibody has been validated for the following applications: ELISA, WB analysis.