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LearnAP08617PU-N
antibody from Acris Antibodies GmbH
Targeting: CAMK2A
CAMKA, CaMKIINalpha, CaMKIIα, KIAA0968
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- AP08617PU-N - Provider product page
- Provider
- Acris Antibodies GmbH
- Proper citation
- Acris Antibodies GmbH Cat#AP08617PU-N, RRID:AB_1975478
- Product name
- anti CAMK2A/B pThr286
- Antibody type
- Polyclonal
- Antigen
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr286 found in rat brain CaM Kinase II.
- Reactivity
- Human, Mouse, Rat, Xenopus
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
Submitted references Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.
Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network.
CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin.
Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization.
Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons.
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
Dual mechanism of a natural CaMKII inhibitor.
Magupalli VG, Mochida S, Yan J, Jiang X, Westenbroek RE, Nairn AC, Scheuer T, Catterall WA
The Journal of biological chemistry 2013 Feb 15;288(7):4637-48
The Journal of biological chemistry 2013 Feb 15;288(7):4637-48
Nonsynaptic NMDA receptors mediate activity-dependent plasticity of gap junctional coupling in the AII amacrine cell network.
Kothmann WW, Trexler EB, Whitaker CM, Li W, Massey SC, O'Brien J
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 16;32(20):6747-59
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 May 16;32(20):6747-59
CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin.
Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU
The Journal of biological chemistry 2010 Jun 4;285(23):17930-7
The Journal of biological chemistry 2010 Jun 4;285(23):17930-7
Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Vest RS, O'Leary H, Coultrap SJ, Kindy MS, Bayer KU
The Journal of biological chemistry 2010 Jul 2;285(27):20675-82
The Journal of biological chemistry 2010 Jul 2;285(27):20675-82
Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization.
Davies KD, Goebel-Goody SM, Coultrap SJ, Browning MD
The Journal of biological chemistry 2008 Nov 28;283(48):33138-46
The Journal of biological chemistry 2008 Nov 28;283(48):33138-46
Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons.
Sun X, Milovanovic M, Zhao Y, Wolf ME
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 16;28(16):4216-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 16;28(16):4216-30
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
Townsend M, Mehta T, Selkoe DJ
The Journal of biological chemistry 2007 Nov 16;282(46):33305-12
The Journal of biological chemistry 2007 Nov 16;282(46):33305-12
Dual mechanism of a natural CaMKII inhibitor.
Vest RS, Davies KD, O'Leary H, Port JD, Bayer KU
Molecular biology of the cell 2007 Dec;18(12):5024-33
Molecular biology of the cell 2007 Dec;18(12):5024-33
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Supportive validation
- Submitted by
- Acris Antibodies GmbH (provider)
- Main image
- Experimental details
- Figure 1. Western blot of rat brain lysate showing specific immunolabeling of the ~50k Alpha- and the ~60k Beta-CaM Kinase II phosphorylated at Thr286 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase). The blot is identical to the control except that it was incubated in lambda-Ptase (1200 units for 30 min) before being exposed to the Anti-Thr286 CaM Kinase II. The immunolabeling is completely eliminated by treatment with lambda-Ptase.
