- MA1-80231 - Invitrogen Antibodies CD8B antibody

Submitted references A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells.

O'Connor MH, Muir R, Chakhtoura M, Fang M, Moysi E, Moir S, Carey AJ, Terk A, Nichols CN, Metcalf T, Petrovas C, Cameron MJ, Tardif V, Haddad EK
Communications biology 2021 May 12;4(1):563

Host IL11 Signaling Suppresses CD4(+) T cell-Mediated Antitumor Responses to Colon Cancer in Mice.

Huynh J, Baloyan D, Chisanga D, Shi W, O'Brien M, Afshar-Sterle S, Alorro M, Pang L, Williams DS, Parslow AC, Thilakasiri P, Eissmann MF, Boon L, Masson F, Chand AL, Ernst M
Cancer immunology research 2021 Jul;9(7):735-747

Early transcriptional changes after UVB treatment in atopic dermatitis include inverse regulation of IL-36γ and IL-37.

Lossius AH, Berents TL, Saetre F, Nilsen HR, Bradley M, Asad S, Haraldsen G, Sundnes O, Holm JØ
Experimental dermatology 2021 Feb;30(2):249-261

CD8+ T cells target cerebrovasculature in children with cerebral malaria.

Riggle BA, Manglani M, Maric D, Johnson KR, Lee MH, Neto OLA, Taylor TE, Seydel KB, Nath A, Miller LH, McGavern DB, Pierce SK
The Journal of clinical investigation 2020 Mar 2;130(3):1128-1138

FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.

Paul R, Luo M, Mo X, Lu J, Yeo SK, Guan JL
Breast cancer research : BCR 2020 Jun 3;22(1):59

Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.

Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T, Bruneval P, Trajanoski Z, Fridman WH, Pagès F, Galon J
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011 Feb 20;29(6):610-8

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer.

Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, Camus M, Gillard M, Bruneval P, Fridman WH, Pagès F, Trajanoski Z, Galon J
Gastroenterology 2010 Apr;138(4):1429-40

Coordination of intratumoral immune reaction and human colorectal cancer recurrence.

Camus M, Tosolini M, Mlecnik B, Pagès F, Kirilovsky A, Berger A, Costes A, Bindea G, Charoentong P, Bruneval P, Trajanoski Z, Fridman WH, Galon J
Cancer research 2009 Mar 15;69(6):2685-93

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Supportive validation

Submitted by: Invitrogen Antibodies (provider)
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Experimental details: NULL

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Fig. 3 Loss of FAK kinase function reduces survival of MMTV-Wnt1-driven basal-like mammary tumors. a Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for Ki67 and corresponding quantification of percentage of positive cells per field of view ( n = 4 for each genotype). b Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for cleaved caspase 3 and corresponding quantification of percentage of positive cells per field of view (Ctrl-Wnt1, cKD-Wnt n = 8; cKO-Wnt n = 7). c Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for CD31 and corresponding quantification of percentage of CD31-positive area per field of view ( n = 3). d Representative images of Ctrl-Wnt1, cKD-Wnt1, and cKO-Wnt tumors immunostained for CD8 and corresponding quantification of percentage of CD8-positive cells per field of view (Ctrl-Wnt1 n = 7; cKD-Wnt, cKO-Wnt n = 5). All statistical tests for c - f include ANOVA followed by Tukey's multiple comparisons test, * p < 0.05, ** p

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Fig. 3 Distribution of CD74 + ID3 + ILC FR in human tonsillar B cell follicles. a Histocytometry analysis showing the frequency of CD19- CD8- CD4- CD74+ ID3+ ILC FR in a tonsillar tissue section (tonsil #1) and b Overlay showing the distribution of CD74+ ID3+ ILC FR (red dots) with respect to CD19 + B cells (dark blue dots) and CD4 + T cells (yellow dots) in the same tonsil. c Bar graph summarizing the frequencies of intra- and extra- follicular ILC FR (CD19- CD8- CD4-CD74+ ID3+) as a frequency of total ILC FR in five tonsils. d Confocal images showing the tonsil area imaged, distribution of B cell follicles as denoted by CD19 (dark blue) and Ki67 (cyan) as well as ID3 positive cells (red). e Close up of a B cell follicle. Dotted lines demarcate the area of the follicle (LZ) as well as the dark zone (DZ) as defined by the density of Ki67 staining (cyan). B cells are shown in blue (CD19 + ), proliferating cells in cyan (Ki67 + ), ID3 in red, CD4 in yellow and CD8 in magenta. f Zoomed in details of the red rectangular enclosures shown in ( e ). The location of a CD74 + (green) ID3 + (red) cell is shown with respect to the positioning of CD19 + (blue) Ki67 (cyan) cells or CD8 + (magenta) and CD4 + (yellow) lymphoid cells. g Zoomed in close-ups confirming the positioning and phenotype of ILC FR (CD19-CD4- CD8- CD74+ ID3+). Images were acquired at x40 (NA 1.3) with no zoom. Images shown are sequential digital magnifications of 150 um ( d ), 30 um ( e ), 10 um ( f ), and 2 um ( g )

MA1-80231

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