Antibody data
- Antibody Data
- Antigen structure
- References [88]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
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- Product number
- 10155-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10155-1-AP, RRID:AB_2078096
- Product name
- CDC42 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CDC42 antibody (Cat. #10155-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Rho GTPase signaling pathway modulates Moraxella catarrhalis invasion into human respiratory epithelial cells by regulating actin polymerization.
Smoking-Induced STC2(+) Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics.
Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.
Up-Regulation of microRNA-185-5p Alleviates Placental Inflammatory Response in Gestational Diabetes Mellitus by Regulating CDC42.
Gut microbiota-derived trimethylamine-N-oxide protects pulmonary vascular barrier integrity via Vav guanine nucleotide exchange factor 3 (VAV3)-mediated cytoskeletal remodelling in acute lung injury.
Galactin-3 regulation of CDC42 promotes neuronal autophagy following spinal cord injury.
Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from Patrinia villosa and evaluation of their drug-likeness.
NUCKS1 exacerbates hepatocellular carcinoma cell proliferation and metastasis via the upregulation of Cdc42.
Knockdown of STK39 inhibits lung cancer brain metastasis by suppressing the CPSF4/NFκB/COX2 pathway.
Alpha-dystroglycan receptor signaling likely influences basement membrane laminin α2 mediated pathology in the stria vascularis of Alport mice.
CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis.
Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism-Dependent and -Independent Mechanisms.
Exosome-Derived CDC42 From Hypoxia-Pretreated Neural Stem Cells Inhibits ACSL4-Related Ferroptosis to Alleviate Vascular Injury in Parkinson's Disease Mice Models.
PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly.
Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation.
Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls.
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Oxyresveratrol suppressed melanogenesis, dendrite formation, and melanosome transport in melanocytes via regulation of the MC1R/cAMP/MITF pathway.
A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.
Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma.
Cell Division Cycle 42 Improves Renal Functions, Fibrosis, Th1/Th17 Infiltration and Inflammation to Some Degree in Diabetic Nephropathy.
Transcriptional adaptation after deletion of Cdc42 in primary T cells.
Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile.
Cdc42 improve SARS-CoV-2 spike protein-induced cellular senescence through activating of Wnt/β-Catenin signaling pathway.
Plexin D1 negatively regulates macrophage-derived foam cell migration via the focal adhesion kinase/Paxillin pathway.
A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells.
SOXC Enhances NGN2-Mediated Reprogramming of Glioblastoma Cells Into Neuron-Like Cells by Modulating RhoA and RAC1/CDC42 Pathway Activity.
The small GTPase Cdc42 regulates shell field morphogenesis in a gastropod mollusk.
ATG9B regulates bacterial internalization via actin rearrangement.
LINC00869 Promotes Hepatocellular Carcinoma Metastasis via Protrusion Formation.
Proangiogenic effect and underlying mechanism of holmium oxide nanoparticles: a new biomaterial for tissue engineering.
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
Role of LGL1 in cerebellar primordium of embryonic mice.
Dahuang-Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases.
Epithelial-specific deletion of FAM20A leads to short root defects.
Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.
Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
Superhydrophilic and topography-regulatable surface grafting on PEEK to improve cellular affinity.
Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis.
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Human Umbilical Cord Mesenchymal Stem Cells Improve the Status of Hypoxic/Ischemic Cerebral Palsy Rats by Downregulating NogoA/NgR/Rho Pathway.
Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation.
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer.
TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb.
Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence.
FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms.
Overexpression of PTPRZ1 Regulates p120/β-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis.
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
eIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42.
PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
Effects of hydrogen peroxide on endothelial function in three-dimensional hydrogel vascular model and regulation mechanism of polar protein Par3.
MicroRNA-124-3p Plays a Crucial Role in Cleft Palate Induced by Retinoic Acid.
Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection.
miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling.
Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line.
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.
FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.
miR-29a inhibits adhesion, migration, and invasion of osteosarcoma cells by suppressing CDC42.
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway.
Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission.
Adenoviral vector-induced silencing of RGMa attenuates blood-brain barrier dysfunction in a rat model of MCAO/reperfusion.
miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network.
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells.
Ma R, Cheng G, Wu Y, Chen J, Lu R, Liu Y
Frontiers in immunology 2026;17:1730864
Frontiers in immunology 2026;17:1730864
Smoking-Induced STC2(+) Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics.
Shen Y, Gao L, Huang Q, Zhou L, Xu C, Wu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e11932
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e11932
Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.
Zhu F, Li H, Li X, Du C, Wang T, Zhou X, Xie X, Shao Y, Huang Y, Hu Y, Guo X, Zhu B, Yu S, Zhang X, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e01242
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e01242
Up-Regulation of microRNA-185-5p Alleviates Placental Inflammatory Response in Gestational Diabetes Mellitus by Regulating CDC42.
Zeng Y, Chen Q, Yin L, Yin X, Zhao D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71605
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71605
Gut microbiota-derived trimethylamine-N-oxide protects pulmonary vascular barrier integrity via Vav guanine nucleotide exchange factor 3 (VAV3)-mediated cytoskeletal remodelling in acute lung injury.
Wang X, Zeng W, Bai Q, Zhong K, Luo Q, Deng J, Cen C, Wang K, Li R, Li J, Zhang J, Ye T, Fang N, Chen X, Wang T
British journal of pharmacology 2026 Apr 23;
British journal of pharmacology 2026 Apr 23;
Galactin-3 regulation of CDC42 promotes neuronal autophagy following spinal cord injury.
Yan L, Zhou X, Li Q, Hong H, Wu C, Gao YJ, Cui Z, Xu G
Frontiers in cellular neuroscience 2025;19:1622825
Frontiers in cellular neuroscience 2025;19:1622825
Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from Patrinia villosa and evaluation of their drug-likeness.
Li X, Ju Y, Yang X, Li T, Wang S, Bao Y, Meng X
Frontiers in immunology 2025;16:1631031
Frontiers in immunology 2025;16:1631031
NUCKS1 exacerbates hepatocellular carcinoma cell proliferation and metastasis via the upregulation of Cdc42.
Fan W, Ma Y, Wu J, Zhang X
American journal of cancer research 2025;15(3):1051-1065
American journal of cancer research 2025;15(3):1051-1065
Knockdown of STK39 inhibits lung cancer brain metastasis by suppressing the CPSF4/NFκB/COX2 pathway.
Shu Y, Dong Y, Li B, Wang Y, Liao Q, Su Z, Wang J, Zuo P, Yuan H, Wang C, Li S, Fan Y, Su X
Journal of neuro-oncology 2025 Sep;174(2):411-430
Journal of neuro-oncology 2025 Sep;174(2):411-430
Alpha-dystroglycan receptor signaling likely influences basement membrane laminin α2 mediated pathology in the stria vascularis of Alport mice.
Meehan DT, Brockhouse J, Connell K, Madison J, Gratton MA, Cosgrove D
Hearing research 2025 Oct;466:109383
Hearing research 2025 Oct;466:109383
CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis.
Cui S, Gao W, Chen Y, Xu Y, Li Z, Wei Y, Jiu Y
EMBO reports 2025 Nov;26(21):5239-5269
EMBO reports 2025 Nov;26(21):5239-5269
Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism-Dependent and -Independent Mechanisms.
Ji X, Zhang W, Xue F, Zeng J, Zhao Q, Sun X, Sun J, Zhou H, Xu Q, Ma G, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07533
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07533
Exosome-Derived CDC42 From Hypoxia-Pretreated Neural Stem Cells Inhibits ACSL4-Related Ferroptosis to Alleviate Vascular Injury in Parkinson's Disease Mice Models.
Li Y, Jiang J, Li J, Liu S, Wang C, Yu Z, Xia Y
Journal of neurochemistry 2025 Mar;169(3):e70027
Journal of neurochemistry 2025 Mar;169(3):e70027
PI(3,4,5)P3-mediated Cdc42 activation regulates macrophage podosome assembly.
Qi Y, Yu CH
Cellular and molecular life sciences : CMLS 2025 Mar 24;82(1):127
Cellular and molecular life sciences : CMLS 2025 Mar 24;82(1):127
Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation.
Yang S, Zhang X, Li X, Li H
Cellular and molecular life sciences : CMLS 2025 Mar 13;82(1):110
Cellular and molecular life sciences : CMLS 2025 Mar 13;82(1):110
Bioactive vascular buds promote collateral vessel formation by grafting on the artificial vessel walls.
Yang Y, Qiu Y, Xu S, Gao H, Wang C, Huang H, Yang Z, Chen X, Zhao F
Bioactive materials 2025 Jul;49:564-575
Bioactive materials 2025 Jul;49:564-575
Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.
Ye Y, Shen F, Yan M, Zhan C, Lv J, Zou M, Wang Z, Ning S, Gao Y, Wu J, Li W
Cell death & disease 2025 Jul 10;16(1):509
Cell death & disease 2025 Jul 10;16(1):509
Oxyresveratrol suppressed melanogenesis, dendrite formation, and melanosome transport in melanocytes via regulation of the MC1R/cAMP/MITF pathway.
Zhang J, Liu S, Guo W, Huang Y, Li N
Scientific reports 2025 Jul 1;15(1):20400
Scientific reports 2025 Jul 1;15(1):20400
A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.
Zhang J, Gao J, Zeng X, Wang Z, Chen C, Rong C, Li S, Cai L, Wang L, Zhang L, Tian Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167570
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167570
Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma.
Liang X, Jiang S, Zhang Q, Li J, Dong K, Zhang H, Wang L, Guan X, Wang Y, Fang T, Xue Y, Li Y, Qin W, Yu J, Wu J, Meng X, Sun W, Weng Y, Li M, Fu G, Pang S, Li L, Fu S, Cai M
iScience 2025 Dec 19;28(12):113886
iScience 2025 Dec 19;28(12):113886
Cell Division Cycle 42 Improves Renal Functions, Fibrosis, Th1/Th17 Infiltration and Inflammation to Some Degree in Diabetic Nephropathy.
Zhao N, Feng C, Zhang Y, Chen H, Ma J
Inflammation 2025 Aug;48(4):1987-1997
Inflammation 2025 Aug;48(4):1987-1997
Transcriptional adaptation after deletion of Cdc42 in primary T cells.
Rochussen AM, Ma CY, Griffiths GM
Journal of cell science 2025 Aug 1;138(15)
Journal of cell science 2025 Aug 1;138(15)
Targeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile.
Yan J, Wang SY, Su Q, Zou MW, Zhou ZY, Shou J, Huo Y
Nature communications 2025 Apr 21;16(1):3748
Nature communications 2025 Apr 21;16(1):3748
Cdc42 improve SARS-CoV-2 spike protein-induced cellular senescence through activating of Wnt/β-Catenin signaling pathway.
Nong C, Wu Z, Yang C, Xu W, Luo L, Zhou J, Shen L, Chen Y, Yuan Y, Hu G
Frontiers in cellular and infection microbiology 2024;14:1449423
Frontiers in cellular and infection microbiology 2024;14:1449423
Plexin D1 negatively regulates macrophage-derived foam cell migration via the focal adhesion kinase/Paxillin pathway.
Li C, Niu Y, Chen J, Geng S, Wu P, Dai L, Dong C, Liu R, Shi Y, Wang X, Gao Z, Liu X, Yang X, Gao S
Biochemical and biophysical research communications 2024 Sep 17;725:150236
Biochemical and biophysical research communications 2024 Sep 17;725:150236
A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells.
Zeng X, Shi C, Han Y, Hu K, Li X, Wei C, Ding L, Cui J, Huang S, Xu Y, Zhang M, Shan W, Luo Q, Yu J, Zheng Z, Li X, Qian P, Huang H
Nature aging 2024 Oct;4(10):1477-1492
Nature aging 2024 Oct;4(10):1477-1492
SOXC Enhances NGN2-Mediated Reprogramming of Glioblastoma Cells Into Neuron-Like Cells by Modulating RhoA and RAC1/CDC42 Pathway Activity.
Yang J, Zhu X, Wang F, Chen Z, Zhang Y, Chen J, Ni H, Zhang CL, Zhuge Q
CNS neuroscience & therapeutics 2024 Oct;30(10):e70075
CNS neuroscience & therapeutics 2024 Oct;30(10):e70075
The small GTPase Cdc42 regulates shell field morphogenesis in a gastropod mollusk.
Liu X, Huan P, Liu B
Developmental biology 2024 Nov;515:7-17
Developmental biology 2024 Nov;515:7-17
ATG9B regulates bacterial internalization via actin rearrangement.
Iibushi J, Nozawa T, Toh H, Nakagawa I
iScience 2024 May 17;27(5):109623
iScience 2024 May 17;27(5):109623
LINC00869 Promotes Hepatocellular Carcinoma Metastasis via Protrusion Formation.
Shao X, Dang Y, Zhang T, Bai N, Huang J, Guo M, Sun L, Li M, Sun X, Zhang X, Han F, Zhang N, Zhuang H, Li Y
Molecular cancer research : MCR 2024 Mar 1;22(3):282-294
Molecular cancer research : MCR 2024 Mar 1;22(3):282-294
Proangiogenic effect and underlying mechanism of holmium oxide nanoparticles: a new biomaterial for tissue engineering.
Luo Y, Zheng Y, Chen Z, Mo M, Xie J, Zhou X, Wu Y, Yang Q, Zheng M, Hu X, Chen L, Lan Z
Journal of nanobiotechnology 2024 Jun 21;22(1):357
Journal of nanobiotechnology 2024 Jun 21;22(1):357
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
Xu J, Wang F, Li Y, Li P, Zhang Y, Xu G, Sun K, Huang Y
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
Role of LGL1 in cerebellar primordium of embryonic mice.
Hou C, Zhang A, Jin Y, Ye C, Li R, Liu Z, Gao J
Neuroreport 2024 Apr 3;35(6):374-379
Neuroreport 2024 Apr 3;35(6):374-379
Dahuang-Taoren, a botanical drug combination, ameliorates adenomyosis via inhibiting Rho GTPases.
Lei Y, Fu X, Chen M, Yi Y, Mao P, Peng L, Qu Z
Frontiers in pharmacology 2023;14:1089004
Frontiers in pharmacology 2023;14:1089004
Epithelial-specific deletion of FAM20A leads to short root defects.
Liu L, Yao L, Lu Z, Jiang L, Zhang X, Liu X, Zhang W, Luan X, Zhang S, Xu W, Wang T, Zhang F, Wei X, Da J, Wang J, Zhang J, Li Y, Jin H, Zhang B
Gene 2023 Oct 30;884:147731
Gene 2023 Oct 30;884:147731
Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.
Lu ZZ, Sun C, Zhang X, Peng Y, Wang Y, Zeng Y, Zhu N, Yuan Y, Zeng MS
Science advances 2023 May 24;9(21):eadg1778
Science advances 2023 May 24;9(21):eadg1778
Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
Wang X, Zhang X, Sun J, Sun Y, Zhang Y, He L, Wang P, Li F, Sun C
Toxicology and applied pharmacology 2023 May 15;467:116492
Toxicology and applied pharmacology 2023 May 15;467:116492
Superhydrophilic and topography-regulatable surface grafting on PEEK to improve cellular affinity.
Zhang B, Leng J, Ouyang Z, Yang Z, Zhang Q, Li Q, Li D, Zhao H
Biomaterials advances 2023 Mar;146:213310
Biomaterials advances 2023 Mar;146:213310
Fam20c regulates the calpain proteolysis system through phosphorylating Calpasatatin to maintain cell homeostasis.
Liu X, Jiang L, Zhang W, Zhang J, Luan X, Zhan Y, Wang T, Da J, Liu L, Zhang S, Guo Y, Zhang K, Wang Z, Miao N, Xie X, Liu P, Li Y, Jin H, Zhang B
Journal of translational medicine 2023 Jun 27;21(1):417
Journal of translational medicine 2023 Jun 27;21(1):417
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Zhang B, Ding J, Ma Z
Viruses 2023 Jun 27;15(7)
Viruses 2023 Jun 27;15(7)
Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
Li Q, Wang Y, Zheng W, Guo J, Zhang S, Gong F, Lu GX, Lin G, Dai J
Human reproduction (Oxford, England) 2023 Jul 5;38(7):1390-1398
Human reproduction (Oxford, England) 2023 Jul 5;38(7):1390-1398
Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice.
Xu W, Yuan Y, Tian Y, Cheng C, Chen Y, Zeng L, Yuan Y, Li D, Zheng L, Luo T
Journal of hazardous materials 2023 Jul 15;454:131470
Journal of hazardous materials 2023 Jul 15;454:131470
Human Umbilical Cord Mesenchymal Stem Cells Improve the Status of Hypoxic/Ischemic Cerebral Palsy Rats by Downregulating NogoA/NgR/Rho Pathway.
Luo Y, Qu J, He Z, Zhang M, Zou Z, Li L, Zhang Y, Ye J
Cell transplantation 2023 Jan-Dec;32:9636897231210069
Cell transplantation 2023 Jan-Dec;32:9636897231210069
Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation.
Ni Y, Qi H, Zhang F, Jiang S, Tang Q, Cai W, Mo W, Miron RJ, Zhang Y
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 17;120(3):e2213837120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 17;120(3):e2213837120
Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation.
Wang DN, Ni JJ, Li JH, Gao YQ, Ni FJ, Zhang ZZ, Fang JY, Lu J, Yao YF
PLoS pathogens 2023 Feb;19(2):e1011189
PLoS pathogens 2023 Feb;19(2):e1011189
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Zhu H, Wen Z, Zhang A, Liu D, Wang H, Cheng Y, Yang X, Xiao Y, Li J, Sun D, Wu B, Gao J
Communications biology 2023 Feb 23;6(1):214
Communications biology 2023 Feb 23;6(1):214
Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer.
Song J, Xu R, Zhang H, Xue X, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Gastroenterology 2023 Dec;165(6):1505-1521.e20
Gastroenterology 2023 Dec;165(6):1505-1521.e20
TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb.
Cai C, Luo Q, Jia L, Xia Y, Lan X, Wei X, Shi S, Liu Y, Wang Y, Xiong Z, Shi R, Huang C, Chen Z
International journal of molecular sciences 2023 Aug 30;24(17)
International journal of molecular sciences 2023 Aug 30;24(17)
Inhibition of Cxcr4 Disrupts Mouse Embryonic Palatal Mesenchymal Cell Migration and Induces Cleft Palate Occurrence.
Zheng X, Zhao X, Wang Y, Chen J, Wang X, Peng X, Ma L, Du J
International journal of molecular sciences 2023 Aug 13;24(16)
International journal of molecular sciences 2023 Aug 13;24(16)
FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms.
St Paul A, Corbett C, Peluzzo A, Kelemen S, Okune R, Haines DS, Preston K, Eguchi S, Autieri MV
Cell reports 2023 Apr 25;42(4):112381
Cell reports 2023 Apr 25;42(4):112381
Overexpression of PTPRZ1 Regulates p120/β-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis.
Ma L, Shen T, Peng H, Wu J, Wang W, Gao X
Journal of oncology 2022;2022:2352360
Journal of oncology 2022;2022:2352360
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
Jiang S, Xu CM, Yao S, Zhang R, Li XZ, Zhang RZ, Xie TY, Xing YQ, Zhang Q, Zhou XJ, Liao L, Dong JJ
Frontiers in endocrinology 2022;13:905703
Frontiers in endocrinology 2022;13:905703
eIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42.
Mei C, Liu C, Gao Y, Dai WT, Zhang W, Li X, Liu ZQ
Frontiers in cell and developmental biology 2022;10:794329
Frontiers in cell and developmental biology 2022;10:794329
PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
Zi J, Xu J, Luo J, Yang X, Zhen Z, Li X, Hu D, Guo Y, Guo H, Ding X, Zhang L
Cells 2022 Oct 11;11(20)
Cells 2022 Oct 11;11(20)
SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion.
Zhang YY, Liang R, Wang SJ, Ye ZW, Wang TY, Chen M, Liu J, Na L, Yang YL, Yang YB, Yuan S, Yin X, Cai XH, Tang YD
The Journal of biological chemistry 2022 Nov;298(11):102511
The Journal of biological chemistry 2022 Nov;298(11):102511
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.
Zhou D, Wang Y, Gui Y, Fu H, Zhou S, Wang Y, Bastacky SI, Stolz DB, Liu Y
Kidney international 2022 Jul;102(1):96-107
Kidney international 2022 Jul;102(1):96-107
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Cang X, Wang Y, Zeng J, Gao J, Yu Q, Lu C, Xu F, Lin J, Zhu J, Wang X
Biochemical and biophysical research communications 2022 Jan 15;588:15-22
Biochemical and biophysical research communications 2022 Jan 15;588:15-22
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Hypermethylation of PRKCZ Regulated by E6 Inhibits Invasion and EMT via Cdc42 in HPV-Related Head and Neck Squamous Cell Carcinoma.
Wang HF, Jiang J, Wu JS, Zhang M, Pang X, Dai L, Tang YL, Liang XH
Cancers 2022 Aug 27;14(17)
Cancers 2022 Aug 27;14(17)
Effects of hydrogen peroxide on endothelial function in three-dimensional hydrogel vascular model and regulation mechanism of polar protein Par3.
Gao H, Wang B, Chen R, Jin Z, Ren L, Yang J, Wang W, Zheng N, Lin R
Biomedical materials (Bristol, England) 2022 Aug 17;17(5)
Biomedical materials (Bristol, England) 2022 Aug 17;17(5)
MicroRNA-124-3p Plays a Crucial Role in Cleft Palate Induced by Retinoic Acid.
Yoshioka H, Mikami Y, Ramakrishnan SS, Suzuki A, Iwata J
Frontiers in cell and developmental biology 2021;9:621045
Frontiers in cell and developmental biology 2021;9:621045
Intestinal Metabolites Influence Macrophage Phagocytosis and Clearance of Bacterial Infection.
O'Callaghan AA, Dempsey E, Iyer N, Stiegeler S, Mercurio K, Corr SC
Frontiers in cellular and infection microbiology 2021;11:622491
Frontiers in cellular and infection microbiology 2021;11:622491
miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling.
Zhang L, Yao L, Zhou W, Tian J, Ruan B, Lu Z, Deng Y, Li Q, Zeng Z, Yang D, Shang R, Xu M, Zhang M, Cheng D, Yang Y, Ding Q, Yu H
Molecular therapy. Nucleic acids 2021 Sep 3;25:567-577
Molecular therapy. Nucleic acids 2021 Sep 3;25:567-577
Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.
Liu S, Gu L, Wu N, Song J, Yan J, Yang S, Feng Y, Wang Z, Wang L, Zhang Y, Jin Y
Cell death & disease 2021 Oct 11;12(10):929
Cell death & disease 2021 Oct 11;12(10):929
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line.
Mulvey CM, Breckels LM, Crook OM, Sanders DJ, Ribeiro ALR, Geladaki A, Christoforou A, Britovšek NK, Hurrell T, Deery MJ, Gatto L, Smith AM, Lilley KS
Nature communications 2021 Oct 1;12(1):5773
Nature communications 2021 Oct 1;12(1):5773
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
Chen X, Xu P, Zhang H, Su X, Guo L, Zhou X, Wang J, Huang P, Zhang Q, Sun R
Oncology letters 2021 Nov;22(5):754
Oncology letters 2021 Nov;22(5):754
PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
Hu Y, Cheng Y, Jiang X, Zhang Y, Wang H, Ren H, Xu Y, Jiang J, Wang Q, Su H, Zhang B, Qiu X
Experimental cell research 2021 Mar 15;400(2):112496
Experimental cell research 2021 Mar 15;400(2):112496
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Wang P, Wang C, Liu C
Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z
Nucleic acids research 2021 Apr 6;49(6):3322-3337
Nucleic acids research 2021 Apr 6;49(6):3322-3337
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.
Zheng D, Wu Z, Han J, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2020 Sep 25;329:109202
Chemico-biological interactions 2020 Sep 25;329:109202
FGD1 exhibits oncogenic properties in hepatocellular carcinoma through regulating cell morphology, autophagy and mitochondrial function.
Zeng Y, Guo Z, Hu Z, Liu M, Chen Y, Chen S, Peng B, Zhang P, Wu Z, Luo H, Zhong F, Jiang K, Lu Y, Yuan G, He S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:110029
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:110029
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Li M, Min W, Wang J, Wang L, Li Y, Zhou N, Yang Z, Qian Q
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer.
Zhao Z, Li L, Du P, Ma L, Zhang W, Zheng L, Lan B, Zhang B, Ma F, Xu B, Zhan Q, Song Y
Theranostics 2019;9(5):1401-1416
Theranostics 2019;9(5):1401-1416
miR-29a inhibits adhesion, migration, and invasion of osteosarcoma cells by suppressing CDC42.
Liu ZJ, Chen SG, Yang YZ, Lu SJ, Zhao XM, Hu B, Zhang L
International journal of clinical and experimental pathology 2019;12(11):4171-4180
International journal of clinical and experimental pathology 2019;12(11):4171-4180
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway.
Wang X, Adegoke EO, Ma M, Huang F, Zhang H, Adeniran SO, Zheng P, Zhang G
Theriogenology 2019 Oct 15;138:84-93
Theriogenology 2019 Oct 15;138:84-93
Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission.
Yu FL, Miao H, Xia J, Jia F, Wang H, Xu F, Guo L
Proteomics 2019 Dec;19(23):e1900009
Proteomics 2019 Dec;19(23):e1900009
Adenoviral vector-induced silencing of RGMa attenuates blood-brain barrier dysfunction in a rat model of MCAO/reperfusion.
Li M, Wen Y, Zhang R, Xie F, Zhang G, Qin X
Brain research bulletin 2018 Sep;142:54-62
Brain research bulletin 2018 Sep;142:54-62
miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene.
Li Y, Zhang H, Gong H, Yuan Y, Li Y, Wang C, Li W, Zhang Z, Liu M, Liu H, Chen J
Journal of experimental & clinical cancer research : CR 2018 Jul 9;37(1):141
Journal of experimental & clinical cancer research : CR 2018 Jul 9;37(1):141
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
Pan X, Zhang R, Xie C, Gan M, Yao S, Yao Y, Jin J, Han T, Huang Y, Gong Y, Wang J, Yu B
American journal of translational research 2017;9(9):4217-4226
American journal of translational research 2017;9(9):4217-4226
Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.
Ma D, Zheng B, Suzuki T, Zhang R, Jiang C, Bai D, Yin W, Yang Z, Zhang X, Hou L, Zhan H, Wen JK
Circulation research 2017 Mar 3;120(5):799-815
Circulation research 2017 Mar 3;120(5):799-815
Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents.
Zhu J, Xu M, Gao M, Zhang Z, Xu Y, Xia T, Liu S
ACS nano 2017 Mar 28;11(3):2637-2651
ACS nano 2017 Mar 28;11(3):2637-2651
Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module.
Liang D, Wang Z, Yan Z, Hou S, Xu W, Wang L, Shang M, Qiao Z
Scientific reports 2017 Mar 2;7:43798
Scientific reports 2017 Mar 2;7:43798
Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network.
Li Y, Wang Y, Kong R, Xue D, Pan S, Chen H, Sun B
Oncotarget 2016 Sep 20;7(38):62460-62473
Oncotarget 2016 Sep 20;7(38):62460-62473
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Deng Z, Huang Z, Yuan M, Yang K, Pang Y
The Journal of general virology 2014 Oct;95(Pt 10):2310-2320
The Journal of general virology 2014 Oct;95(Pt 10):2310-2320
Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets.
Zhou T, Zhang B, Wei P, Du Y, Zhou H, Yu M, Yan L, Zhang W, Nie G, Chen C, Tu Y, Wei T
Biomaterials 2014 Dec;35(37):9833-9843
Biomaterials 2014 Dec;35(37):9833-9843
α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.
Zallocchi M, Johnson BM, Meehan DT, Delimont D, Cosgrove D
The American journal of pathology 2013 Oct;183(4):1269-1280
The American journal of pathology 2013 Oct;183(4):1269-1280
Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells.
Ju J, Qi Z, Cai X, Cao P, Liu N, Wang S, Chen Y
Toxicology in vitro : an international journal published in association with BIBRA 2013 Feb;27(1):232-8
Toxicology in vitro : an international journal published in association with BIBRA 2013 Feb;27(1):232-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10155-1-AP(CDC42 antibody) at dilution of 1:0
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The CDC42 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CDC42. This antibody recognizes human, mouse, rat antigen. The CDC42 antibody has been validated for the following applications: ELISA, WB, IHC analysis.