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- References [22]
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- Product number
- 15646-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15646-1-AP, RRID:AB_2252572
- Product name
- POLD1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated POLD1 antibody (Cat. #15646-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway.
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
A novel IBA57 variant is associated with mitochondrial iron-sulfur protein deficiency and necrotizing myelopathy in dogs.
DNA repair pathways-targeted cyclovirobuxine inhibits castration-resistant prostate cancer growth by promoting cell apoptosis and cycle arrest.
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Autoregulatory control of mitochondrial glutathione homeostasis.
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma.
Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.
POLD1 as a Prognostic Biomarker Correlated with Cell Proliferation and Immune Infiltration in Clear Cell Renal Cell Carcinoma.
Cadherin-16 inhibits thyroid carcinoma cell proliferation and invasion.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand.
Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
ISCA1 mutation in a patient with infantile-onset leukodystrophy causes defects in mitochondrial [4Fe-4S] proteins.
Elevated expression of POLD1 is associated with poor prognosis in breast cancer.
Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.
Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.
p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast cancer.
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Gong Y, Wang J, Pan M, Zhao Y, Zhang H, Zhang F, Liu J, Yang J, Hu J
International immunopharmacology 2024 Sep 10;138:112542
International immunopharmacology 2024 Sep 10;138:112542
METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.
Ast T, Itoh Y, Sadre S, McCoy JG, Namkoong G, Wengrod JC, Chicherin I, Joshi PR, Kamenski P, Suess DLM, Amunts A, Mootha VK
Molecular cell 2024 Jan 18;84(2):359-374.e8
Molecular cell 2024 Jan 18;84(2):359-374.e8
A novel IBA57 variant is associated with mitochondrial iron-sulfur protein deficiency and necrotizing myelopathy in dogs.
Mandigers PJJ, Stehling O, Vos-Loohuis M, Van Steenbeek FG, Lill R, Leegwater PA
Frontiers in genetics 2023;14:1190222
Frontiers in genetics 2023;14:1190222
DNA repair pathways-targeted cyclovirobuxine inhibits castration-resistant prostate cancer growth by promoting cell apoptosis and cycle arrest.
Gao K, Zhu S, Shao Q, Qi Y, Zhang C, Li X, Guo J, Wu G, Jiang H
Translational oncology 2023 Sep;35:101708
Translational oncology 2023 Sep;35:101708
Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.
Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075
The Journal of biological chemistry 2023 Sep;299(9):105075
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma.
Jeon H, Byun J, Kang H, Kim K, Lee E, Kim JH, Hong CK, Song SW, Kim YH, Chong S, Kim JH, Nam SJ, Park JE, Lee S
Journal of translational medicine 2023 Feb 2;21(1):69
Journal of translational medicine 2023 Feb 2;21(1):69
Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.
Wang M, Xu X, Li J, Gao Z, Ding Y, Chen X, Xiang Q, Shen L
Aging 2023 Dec 11;15(23):14210-14241
Aging 2023 Dec 11;15(23):14210-14241
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.
Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, Lee HJ, Dame MK, Attili D, Chen Y, Varani J, Spence JR, Kovbasnjuk O, Colacino JA, Lyssiotis CA, Lin HC, Shah YM, Xue X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693
POLD1 as a Prognostic Biomarker Correlated with Cell Proliferation and Immune Infiltration in Clear Cell Renal Cell Carcinoma.
Tian J, Cheng C, Gao J, Fu G, Xu Z, Chen X, Wu Y, Jin B
International journal of molecular sciences 2023 Apr 6;24(7)
International journal of molecular sciences 2023 Apr 6;24(7)
Cadherin-16 inhibits thyroid carcinoma cell proliferation and invasion.
Yang X, Li Y, Liu G, Zha W, Liu Y
Oncology letters 2022 May;23(5):145
Oncology letters 2022 May;23(5):145
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H
Cell 2022 May 26;185(11):1974-1985.e12
Cell 2022 May 26;185(11):1974-1985.e12
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89
Nature cancer 2022 Jan;3(1):75-89
Hepatitis B virus cccDNA is formed through distinct repair processes of each strand.
Wei L, Ploss A
Nature communications 2021 Mar 11;12(1):1591
Nature communications 2021 Mar 11;12(1):1591
Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation.
Wei L, Ploss A
Nature microbiology 2020 May;5(5):715-726
Nature microbiology 2020 May;5(5):715-726
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA
Haematologica 2019 Sep;104(9):1756-1767
Haematologica 2019 Sep;104(9):1756-1767
ISCA1 mutation in a patient with infantile-onset leukodystrophy causes defects in mitochondrial [4Fe-4S] proteins.
Torraco A, Stehling O, Stümpfig C, Rösser R, De Rasmo D, Fiermonte G, Verrigni D, Rizza T, Vozza A, Di Nottia M, Diodato D, Martinelli D, Piemonte F, Dionisi-Vici C, Bertini E, Lill R, Carrozzo R
Human molecular genetics 2018 Oct 15;27(20):3650
Human molecular genetics 2018 Oct 15;27(20):3650
Elevated expression of POLD1 is associated with poor prognosis in breast cancer.
Qin Q, Tan Q, Li J, Yang W, Lian B, Mo Q, Wei C
Oncology letters 2018 Nov;16(5):5591-5598
Oncology letters 2018 Nov;16(5):5591-5598
Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients.
Kim KS, Maio N, Singh A, Rouault TA
Human molecular genetics 2018 Mar 1;27(5):837-852
Human molecular genetics 2018 Mar 1;27(5):837-852
Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.
Upadhyay AS, Stehling O, Panayiotou C, Rösser R, Lill R, Överby AK
The Journal of biological chemistry 2017 Aug 18;292(33):13879-13889
The Journal of biological chemistry 2017 Aug 18;292(33):13879-13889
p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast cancer.
Zhang L, Yang W, Zhu X, Wei C
OncoTargets and therapy 2016;9:1351-60
OncoTargets and therapy 2016;9:1351-60
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Stehling O, Vashisht AA, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA, Lill R
Science (New York, N.Y.) 2012 Jul 13;337(6091):195-9
Science (New York, N.Y.) 2012 Jul 13;337(6091):195-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The POLD1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human POLD1. This antibody recognizes human, mouse, rat antigen. The POLD1 antibody has been validated for the following applications: ELISA, WB analysis.
