BS4786

antibody from Bioworld Technology, Inc
Targeting: DOK2 Dok-2, p56dok-2
Provider product page for BS4786
Western blot
Immunocytochemistry

Antibody data

Product number
BS4786 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS4786, RRID:AB_1662660
Product name
Dok 2 (phospho Y299) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human Dok-2 around the phosphorylation site of Tyrosine 299.
Description
Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok-1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, is a member of a class of ¡ùdocking¡ì proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DOK2 protein structure - BS4786 shown in red.