ABIN362353

antibody from antibodies-online

Targeting: DOK2 Dok-2, p56dok-2

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN362353

Provider

antibodies-online

Product name

anti-DOK2 (pTyr299) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pTyr299 (G-E-Y (p) -A-V) derived from Human p56Dok-2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human

Host

Rabbit

Epitope

pTyr299

Isotype

IgG

Vial size

50 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.

Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y
Genes to cells : devoted to molecular & cellular mechanisms 2006 Feb;11(2):143-51

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.

Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W
The Journal of cell biology 2000 Jun 26;149(7):1419-32

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Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.

Lemay S, Davidson D, Latour S, Veillette A
Molecular and cellular biology 2000 Apr;20(8):2743-54

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Characterization of a novel member of the DOK family that binds and modulates Abl signaling.

Cong F, Yuan B, Goff SP
Molecular and cellular biology 1999 Dec;19(12):8314-25