BS8468

antibody from Bioworld Technology, Inc
Targeting: ERCC1 RAD10
Provider product page for BS8468
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8468 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ERCC1 polyclonal antibody
Antibody type
Polyclonal
Antigen
DNA excision repair protein ERCC-1; : ERCC1
Description
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5' incisions during DNA repair. The ERCC1-XPF endonuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ERCC1 protein structure - BS8468 shown in red.