Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB273-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human FGF-9 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human FGF-9 in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant human (rh) FGF-4, 5, 6, 7, 16, rhFGF acidic, or rhFGF basic is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
P31371
- Isotype
- IgG
- Antibody clone number
- 36912
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells.
Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas.
Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina.
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
Sun C, Fukui H, Hara K, Zhang X, Kitayama Y, Eda H, Tomita T, Oshima T, Kikuchi S, Watari J, Sasako M, Miwa H
BMC cancer 2015 Apr 30;15:333
BMC cancer 2015 Apr 30;15:333
Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas.
Hendrix ND, Wu R, Kuick R, Schwartz DR, Fearon ER, Cho KR
Cancer research 2006 Feb 1;66(3):1354-62
Cancer research 2006 Feb 1;66(3):1354-62
Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina.
Cinaroglu A, Ozmen Y, Ozdemir A, Ozcan F, Ergorul C, Cayirlioglu P, Hicks D, Bugra K
Journal of neuroscience research 2005 Feb 1;79(3):329-39
Journal of neuroscience research 2005 Feb 1;79(3):329-39
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B
Development (Cambridge, England) 2004 Aug;131(15):3627-36
Development (Cambridge, England) 2004 Aug;131(15):3627-36
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by FGF-9 and Neutralization by Human FGF-9 Antibody. Recombinant Human FGF-9 (Catalog # 273-F9) stimulates proliferation in the Balb/3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human FGF-9 (10 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human FGF-9 Monoclonal Antibody (Catalog # MAB273). The ND50 is typically 0.1-0.6 µg/mL.