BS4839

antibody from Bioworld Technology, Inc

Targeting: REL c-Rel, I-Rel

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS4839

Provider

Bioworld Technology, Inc

Product name

c Rel (phospho S503) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human c-Rel around the phosphorylation site of Serine 503.

Description

c-Rel is the cellular cognate of v-Rel, the avian reticuloendotheliosis virus strain T transforming gene. v-Rel encodes a phosphoprotein that is located in the cytoplasm of transformed spleen cells and in the nucleus of non-transformed fibroblasts, in contrast to the c-Rel protein, which is cytoplasmic. c-Rel has been shown to represent a constituent of the °ÙB site binding transcription factor NF°ÙB, which plays a crucial role in the expression of immunoglobulin °Ù light chain gene. In contrast to c-Rel, v-Rel is truncated in its C-terminal transactivation domain and does not appear to function as a transcriptional transactivator. It has thus been postulated that v-Rel may interfere with the normal transcription of NF°ÙB regulated genes and thus cause transformation by a mechanism analogous to v-ErbA, which binds to the thyroid hormoneresponsive region in certain erythroid genes needed for differentiation, but cannot be activated by thyroid hormone.

Reactivity

Human

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.