10408-1-AP

antibody from Proteintech Group

Targeting: GAD1 GAD

Provider product page for 10408-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [41]
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Product number: 10408-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10408-1-AP, RRID:AB_2107733
Product name: GAD1 antibody
Antibody type: Polyclonal
Description: GAD1 antibody (Cat. #10408-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GAD1 protein structure - 10408-1-AP shown in red.

Submitted references Gamma-aminobutyric acid transaminase mediates tumor suppression in renal cell carcinoma through the cGAS-STING-interferon-β axis.

Feng Y, Cao S, Cai T, Lu Y, Jiang B, Lv Z, Tang J, Gao F, Zhao X, Liu C, Wang Q, Feng J, Wang Z, Ai Q, Cheng Q, Fan W, Li H
Scientific reports 2026 Mar 11;16(1)

Gastrin releasing peptide receptor antagonism in the paraventricular nucleus exerts antihypertensive effects in 2K1C rats.

Wang XM, Liu JJ, Wang YP, Bai C, Issotina Zibrila A, Xia WJ, Yang RN, Kang YM, Yu XJ
Toxicology and applied pharmacology 2026 Jan;506:117620

Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism.

Burke FF, Randell AM, Sparkes KM, Salia S, Hinks M, Martin Y, Porter Z, Hynes C, Maekawa AS, Sled J, Wilson DR, Kaushik DK, Kakumani PK, Walling SG, Cahill LS, Swift-Gallant A
Translational psychiatry 2026 Jan 30;16(1)

A causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia.

Zhou D, Zhang Y, Yang Z, Zhang C, Zhang Q, Huo J, Cui K, Wu Y, Chang H, Wang C, Xiao X, Cai X, Li M
Science advances 2026 Jan 16;12(3):eadw7667

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex.

Tokudome K, Ueki M, Homma T, Matsunaga S, Shimizu S, Ohno Y, Tomita S
British journal of pharmacology 2026 Apr 8;

A skin-hypothalamus axis couples heat stress and metabolic dysfunction.

Zhou HY, Feng X, Wen J, Xiao Y, Wang LW, Chen LY, Xie GQ, Zhao JJ, Huang Y, Luo XH
Cell 2026 Apr 21;

RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.

Huo Y, Zhao D, Zhu X, Zheng N, Yang D, Meng J, Chen Y, Zhang YW
Theranostics 2025;15(4):1338-1352

Noradrenergic α(2) Receptor Modulates Cav2.2-Mediated Nociception in Parkinson's Disease Through Spinal Neuro-glial Network.

Cui S, He Y, Gu Y, Wu H, Guo D, Zhang L
Molecular neurobiology 2025 Nov 19;63(1):86

Molecular signatures of regional vulnerability to tauopathy in excitatory cortical neurons.

Broekaart DWM, Sharma A, Ramakrishnan A, Chongtham A, Günther DM, Subramaniyan S, Wang M, Patel V, Zhang B, Grinberg LT, Blitzer RD, Schmidt EF, Shen L, Hof PR, Pereira AC
Acta neuropathologica 2025 Jun 7;149(1):60

Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling.

Dong J, Wu Y, Che J, He Z, Zhang J
Cancer & metabolism 2025 Jun 23;13(1):33

Neurotransmitter imbalance and amygdala synaptic plasticity in lumbar disc herniation-induced chronic pain and related emotional Disturbances:A multi-omics analysis.

Huang Z, Tan H, Fu Y, Xie H, Tan H, Gao K, Lou H
Neuropharmacology 2025 Jun 15;271:110405

Effect of Voluntary Wheel Running on Anxiety- and Depression-Like Behaviors in Fluoride-Exposed Mice.

Qi M, Wu Y, Shi H, Liu J, Zhu R, Wang J, Rafique A, Yang B, Niu R, Zhang D, Sun Z
Biological trace element research 2025 Jul;203(7):3724-3741

Identification and validation of glucose metabolism-related gene signature in endometrial cancer.

Jiang J, Xia N, Yang M, Qiu P, Zhu W, Chen J, Zhu J
BMC cancer 2025 Jan 7;25(1):30

GABA regulates metabolic reprogramming to mediate the development of brain metastasis in non-small cell lung cancer.

Xie M, Qin H, Liu L, Wu J, Zhao Z, Zhao Y, Fang Y, Yu X, Su C
Journal of experimental & clinical cancer research : CR 2025 Feb 19;44(1):61

Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice.

Zhao D, Huo Y, Zheng N, Zhu X, Yang D, Zhou Y, Wang S, Jiang Y, Wu Y, Zhang YW
PLoS biology 2025 Apr;23(4):e3003047

Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function.

Huang L, Sun S, Jiang G, Xie G, Yang Y, Chen S, Luo J, Lv C, Li X, Liao J, Wang Z, Zhang Z, Xiong J
Frontiers in molecular neuroscience 2024;17:1459858

All-optical reporting of inhibitory receptor driving force in the nervous system.

Selfe JS, Steyn TJS, Shorer EF, Burman RJ, Düsterwald KM, Kraitzick AZ, Abdelfattah AS, Schreiter ER, Newey SE, Akerman CJ, Raimondo JV
Nature communications 2024 Oct 16;15(1):8913

Perinatal exposure to bisphenol A impairs cognitive function via the gamma-aminobutyric acid signaling pathway in male rat offspring.

Guo Y, Kang Y, Bai W, Liu Q, Zhang R, Wang Y, Wang C
Environmental toxicology 2024 Mar;39(3):1235-1244

Metabolic reprogramming driven by EZH2 inhibition depends on cell-matrix interactions.

W-M Fan T, Islam JMM, Higashi RM, Lin P, Brainson CF, Lane AN
The Journal of biological chemistry 2024 Jan;300(1):105485

The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.

Li N, Xu X, Liu D, Gao J, Gao Y, Wu X, Sheng H, Li Q, Mi J
Theranostics 2023;13(4):1355-1369

Low-dose bisphenols exposure sex-specifically induces neurodevelopmental toxicity in juvenile rats and the antagonism of EGCG.

Meng L, Gui S, Ouyang Z, Wu Y, Zhuang Y, Pang Q, Fan R
Journal of hazardous materials 2023 Oct 5;459:132074

The PrL(Glu)→avBNST(GABA) circuit rapidly modulates depression-like behaviors in male mice.

Chen JY, Wu K, Guo MM, Song W, Huang ST, Zhang YM
iScience 2023 Oct 20;26(10):107878

GAD1-mediated GABA elicits aggressive characteristics of human oral cancer cells.

Dou Z, Li M, Shen Z, Jiang H, Pang X, Li T, Liang X, Tang Y
Biochemical and biophysical research communications 2023 Nov 12;681:80-89

Amelioration of olfactory dysfunction in a mouse model of Parkinson's disease via enhancing GABAergic signaling.

Liu XY, Wang K, Deng XH, Wei YH, Guo R, Liu SF, Zhu YF, Zhong JJ, Zheng JY, Wang MD, Ye QH, He JQ, Guo KH, Zhu JR, Huang SQ, Chen ZX, Lv CS, Wen L
Cell & bioscience 2023 Jun 3;13(1):101

GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.

Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344

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Xu Y, Lian Y, Li J, Zhang Y, Liu Y, Wang X, Ma J, Li F
Frontiers in pharmacology 2022;13:939169

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.

Huang D, Wang Y, Thompson JW, Yin T, Alexander PB, Qin D, Mudgal P, Wu H, Liang Y, Tan L, Pan C, Yuan L, Wan Y, Li QJ, Wang XF
Nature cell biology 2022 Feb;24(2):230-241

Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats.

Yu XJ, Chen YM, Liu XJ, Bai XJ, Liu KL, Fu LY, Gao HL, Sun TZ, Shi XL, Qi J, Li Y, Kang YM
Toxicology and applied pharmacology 2022 Feb 15;437:115893

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Jia F, Li H, Jiao Q, Li C, Fu L, Cui C, Jiang H, Zhang L
Cell death & disease 2022 Apr 30;13(4):418

Intrathecally administered pizotifen alleviates neuropathic and inflammatory pain in mice by enhancing GABAergic inhibition.

Li J, Zhang X, Xu C, Liu YX, Ge C, Zhao Z, Zhu YB, Bao HG
Neuroscience letters 2022 Apr 1;775:136545

Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice.

Zhou L, Tao X, Pang G, Mu M, Sun Q, Liu F, Hu Y, Tao H, Li B, Xu K
Frontiers in pharmacology 2021;12:661304

BNST(AV) (GABA)-PVN(CRF) Circuit Regulates Visceral Hypersensitivity Induced by Maternal Separation in Vgat-Cre Mice.

Huang ST, Song ZJ, Liu Y, Luo WC, Yin Q, Zhang YM
Frontiers in pharmacology 2021;12:615202

Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission.

Wu L, Zhang T, Chen K, Lu C, Liu XF, Zhou JL, Huang YK, Yan H, Chen Y, Zhang CJ, Li JF, Shi SQ, Ren P, Huang X
Phytotherapy research : PTR 2021 Jan;35(1):404-414

Enriched Environment Promotes Cognitive Function Recovery following Cerebral Ischemic Injury via Upregulating GABAergic and Glutamatergic Systems in the Contralateral Hippocampus.

Wang Y, Wu J, Xie H, Wang L, Wang C, Wu Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:8850119

Soporific Effect of Modified Suanzaoren Decoction and Its Effects on the Expression of CCK-8 and Orexin-A.

Zhan LH, Dong YJ, Yang K, Lei SS, Li B, Teng X, Zhou C, Luo R, Yu QX, Jin HY, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6984087

Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction.

Zaldua S, Damen FC, Pisharody R, Thomas R, Fan KD, Ekkurthi GK, Scheinman SB, Alahmadi S, Marottoli FM, Alford S, Cai K, Tai LM
Heliyon 2020 May;6(5):e03919

RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.

Eshraghi M, Ramírez-Jarquín UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S
Science advances 2020 May;6(18):eaaz7001

Long non-coding RNA Neat1 regulates adaptive behavioural response to stress in mice.

Kukharsky MS, Ninkina NN, An H, Telezhkin V, Wei W, Meritens CR, Cooper-Knock J, Nakagawa S, Hirose T, Buchman VL, Shelkovnikova TA
Translational psychiatry 2020 May 28;10(1):171

Disinhibition of PVN-projecting GABAergic neurons in AV region in BNST participates in visceral hypersensitivity in rats.

Song Y, Meng QX, Wu K, Hua R, Song ZJ, Song Y, Qin X, Cao JL, Zhang YM
Psychoneuroendocrinology 2020 Jul;117:104690

c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.

Wang R, Zhang W, Dong Z, Qi Y, Hultström M, Zhou X, Lai EY
Acta physiologica (Oxford, England) 2017 Feb;219(2):494-509

Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension.

Chen HH, Cheng PW, Ho WY, Lu PJ, Lai CC, Tseng YM, Fang HC, Sun GC, Hsiao M, Liu CP, Tseng CJ
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