GRK4

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Description

G protein-coupled receptor kinase 4

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins

Chromosome

4:p16.3 (2963608 - 3040747)

Ensembl ID

ENSG00000125388  (ver. 84.38)

Orthologs

Mouse Grk4: ENSMUSG00000052783

UniProt

P32298

neXtProt

NX_P32298

Human splice variants
Mouse splice variants