17449-1-AP

antibody from Proteintech Group

Targeting: HDAC4 BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288

Provider product page for 17449-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [47]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 17449-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17449-1-AP, RRID:AB_2118864
Product name: HDAC4 antibody
Antibody type: Polyclonal
Description: KD/KO validated HDAC4 antibody (Cat. #17449-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HDAC4 protein structure - 17449-1-AP shown in red.

Submitted references Glucocorticoid receptor represses the LGR4 gene by binding to the nGRE sequence and recruiting HDAC4 in mice monocytes.

Fang Q, Chen B, Lu S, Li G, Chen D, Song W, Zhu Q, Ding P, Zhu D, Gao Y, Liu P
Bone 2026 Jul;208:117875

Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function.

Peng X, Zhou P, Zhang K, Chen L, Tang M, Zhou Q, Peng J, Yang L
Cell death & disease 2025 Oct 21;16(1):743

The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer.

Shang T, Jiang T, Tan J, Jiang H, Xu M, Pan Y, Lin Y, Cui X, Tian C, Feng H, Chen Y, Pei M, Geng X, Cheng S, Tan Y, Wang H, Dong L
Signal transduction and targeted therapy 2025 Oct 14;10(1):341

Nucleocytoplasmic HDAC Inhibition Drives Acetylation-dependent TDP-43 Mislocalization and Disulfide-linked Oligomerization.

Lukianenko N, Kang DM, Bekci A, Kim YK, Lim S
Journal of molecular biology 2025 Oct 1;437(19):169318

IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency.

Ghosh A, Britto J, Chandran B, Roy A
Journal of virology 2025 Mar 18;99(3):e0154924

HDAC4 suppresses porcine epidemic diarrhea virus infection through negatively regulating MEF2A-GLUT1/3 axis- mediated glucose uptake.

Wang X, Wang L, Li D, Liu Y, Shang Q, Liu Y, Zhang L, Xu Z, Huang C, Song C
Veterinary microbiology 2025 Jun;305:110520

N(6)-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.

Rui Y, Zhang H, Yu K, Qiao S, Gao C, Wang X, Yang W, Asadikaram G, Li Z, Zhang K, Peng J, Li J, He J, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2408488

Focal Adhesion Kinase Promotes Calcification of Vascular Smooth Muscle Cells via Regulation of Histone Deacetylase 4 and 5.

Tian W, Singh K, Kajuluri LP, Lu J, Lee S, Roh K, Nicholson CJ, Jiang W, Barnes HJ, Sato T, Boerboom S, Ostrom K, Li RH, Birchenough C, Moore E, Tattersfield H, Sigurslid HH, Mahamdeh MS, Mosquera JV, Hodonsky CJ, Johnson AL, Chou EL, Nigwekar S, Lindsay ME, Bloch DB, Lino Cardenas CL, Ichinose F, Miller CL, Wein MN, Malhotra R
Arteriosclerosis, thrombosis, and vascular biology 2025 Dec;45(12):e565-e583

Investigating the Role and Regulatory Mechanisms of the Histone Deacetylase 4 Gene in Chondrocyte Differentiation Impairments Associated With Kashin-Beck Disease.

Yang L, Wang C, Zhou J, Chen F, Liu L, Bai L, Wang X, Guo X, Yi S
Journal of biochemical and molecular toxicology 2025 Apr;39(4):e70231

Inhibition of Hepatoblastoma by Ganoderma Lucidum Polysaccharide via the Induction of HDAC4-p16-RB Axis-Mediated Cellular Senescence.

Ye T, Ge Y, Zhang J, Gao H, Zhang PC, Shen R, Peng C, Liu B, Song H
Phytotherapy research : PTR 2025 Apr 6;

Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification.

Lim YH, Park YJ, Lee J, Kim JH
Animal cells and systems 2024;28(1):66-74

Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.

Chen Y, Liu J, Zhang Q, Chai L, Chen H, Li D, Wang Y, Qiu Y, Shen N, Zhang J, Wang Q, Wang J, Xie X, Li S, Li M
European journal of pharmacology 2024 May 5;970:176483

HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model.

Gu X, Li F, Che X, Wei X, Li P
BMC musculoskeletal disorders 2024 Jun 15;25(1):467

Prognostic and therapeutic model based on disulfidptosis-related genes for patients with clear cell renal cell carcinoma.

Xin S, Su J, Li R, Cao Q, Wang H, Wei Z, Wang C, Zhang C, Zhang J, Zhang Z, Li G, Qin W
Heliyon 2024 Jun 15;10(11):e32258

Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.

Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144

High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells.

Hui Y, Kuang L, Zhong Y, Tang Y, Xu Z, Zheng T
iScience 2024 Jan 19;27(1):108689

Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism.

Ning JY, Yang HY, Xie TK, Chen YX, Han J
International journal of ophthalmology 2023;16(8):1210-1217

The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.

Zheng X, Su F, Lei M, Li J, Zhang C, Zhang Y, Wei M, Li W, Chen S, Liu Y, Gao Q, Hao L
European journal of pharmacology 2023 Oct 15;957:175969

Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.

Gu X, Shen N, Huang C, Wang HL
Toxicology 2023 Nov;499:153639

Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma.

Qian L, Liang Z, Wang Z, Wang J, Li X, Zhao J, Li Z, Chen L, Liu Y, Ju Y, Li C, Meng S
Journal of molecular cell biology 2023 Nov 27;15(5)

HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.

Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158

Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons.

Xu Y, Wei S, Zhu L, Huang C, Yang T, Wang S, Zhang Y, Duan Y, Li X, Wang Z, Pan W
Ecotoxicology and environmental safety 2023 Mar 15;253:114660

Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis.

Lax A, Soler F, Fernandez Del Palacio MJ, Pascual-Oliver S, Ballester MR, Fuster JJ, Pascual-Figal D, Asensio-Lopez MDC
Molecular therapy. Nucleic acids 2023 Jun 13;32:704-720

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells.

Wang L, Liu L, Han C, Jiang H, Ma K, Guo S, Xia Y, Wan F, Huang J, Xiong N, Wang T
Brain sciences 2023 Apr 16;13(4)

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.

He X, Sun T, Zhang P, Xia Z, Gao C, Ren H, Ji D
Frontiers in medicine 2022;9:848938

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.

Wang T, Lu Z, Han T, Wang Y, Gan M, Wang JB
International journal of biological sciences 2022;18(11):4452-4465

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.

Feng Y, Ma Z, Pan M, Xu L, Feng J, Zhang Y, Shao C, Guo K, Duan H, Zhang Y, Zhang Y, Zhang J, Lu D, Ren X, Han J, Li X, Yan X
Cell death & disease 2022 May 20;13(5):480

Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.

Jiang A, Guo H, Zhang L, Jiang X, Zhang X, Wu W, Liu H
Molecular and cellular biology 2022 Jan 20;42(1):e0032721

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.

Shao C, Guo K, Xu L, Zhang Y, Duan H, Feng Y, Pan M, Lu D, Ren X, Ganti AK, Hakozaki T, Han J, Yan X, Ma Z
Translational lung cancer research 2021 Dec;10(12):4558-4573

Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.

Mou Z, Yang C, Zhang Z, Wu S, Xu C, Cheng Z, Dai X, Chen X, Ou Y, Jiang H
Frontiers in genetics 2020;11:566918

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.

Guo Q, Wang T, Yang Y, Gao L, Zhao Q, Zhang W, Xi T, Zheng L
Molecular therapy. Nucleic acids 2020 Sep 4;21:527-541

Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.

Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801

Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.

Shi W, Huang Y, Zhao X, Xie Z, Dong W, Li R, Chen Y, Li Z, Wang W, Ye Z, Liu S, Zhang L, Liang X
Biochemical and biophysical research communications 2020 Dec 17;533(4):1061-1068

Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.

Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411

Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival.

Wang Z, Wang H, Shen P, Xie R
Annals of clinical and laboratory science 2019 Mar;49(2):189-192

TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling.

Li J, Liu C, Li Y, Zheng Q, Xu Y, Liu B, Sun W, Li Y, Ji S, Liu M, Zhang J, Zhao D, Du R, Liu Z, Zhong G, Sun C, Wang Y, Song J, Zhang S, Qin J, Ling S, Wang X, Li Y
Nature communications 2019 Apr 8;10(1):1589

The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.

He B, Dai L, Zhang X, Chen D, Wu J, Feng X, Zhang Y, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2018;14(13):1845-1858

Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.

Xu Q, Liu X, Zhu S, Hu X, Niu H, Zhang X, Zhu D, Nesa EU, Tian K, Yuan H
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922

Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.

Li Y, Li L, Qian Z, Lin B, Chen J, Luo Y, Qu J, Raj JU, Gou D
Journal of the American Heart Association 2018 Mar 7;7(6)

Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.

Niu Y, Wang T, Liu S, Yuan H, Li H, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2372-2381

Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.

Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125

Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.

Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y, Jin J
International journal of oncology 2015;46(6):2535-45

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.

Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1237-48

Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.

Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD
Cell 2014 Jul 31;158(3):607-19

HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.

He M, Zhang B, Wei X, Wang Z, Fan B, Du P, Zhang Y, Jian W, Chen L, Wang L, Fang H, Li X, Wang PA, Yi F
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 17449-1-AP(HDAC4 antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HDAC4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC4. This antibody recognizes human,mouse,rat antigen. The HDAC4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 17449-1-AP.pdf

: Show more