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Learn17449-1-AP
antibody from Proteintech Group
Targeting: HDAC4
BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, KIAA0288
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 17449-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17449-1-AP, RRID:AB_2118864
- Product name
- HDAC4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC4 antibody (Cat. #17449-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification.
Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.
High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells.
Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism.
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons.
Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis.
Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells.
Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.
Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.
Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.
Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival.
TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling.
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.
Lim YH, Park YJ, Lee J, Kim JH
Animal cells and systems 2024;28(1):66-74
Animal cells and systems 2024;28(1):66-74
Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.
Chen Y, Liu J, Zhang Q, Chai L, Chen H, Li D, Wang Y, Qiu Y, Shen N, Zhang J, Wang Q, Wang J, Xie X, Li S, Li M
European journal of pharmacology 2024 May 5;970:176483
European journal of pharmacology 2024 May 5;970:176483
High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells.
Hui Y, Kuang L, Zhong Y, Tang Y, Xu Z, Zheng T
iScience 2024 Jan 19;27(1):108689
iScience 2024 Jan 19;27(1):108689
Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism.
Ning JY, Yang HY, Xie TK, Chen YX, Han J
International journal of ophthalmology 2023;16(8):1210-1217
International journal of ophthalmology 2023;16(8):1210-1217
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Zheng X, Su F, Lei M, Li J, Zhang C, Zhang Y, Wei M, Li W, Chen S, Liu Y, Gao Q, Hao L
European journal of pharmacology 2023 Oct 15;957:175969
European journal of pharmacology 2023 Oct 15;957:175969
Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.
Gu X, Shen N, Huang C, Wang HL
Toxicology 2023 Nov;499:153639
Toxicology 2023 Nov;499:153639
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158
Cancer letters 2023 May 28;562:216158
Low expression of the intestinal metabolite butyric acid and the corresponding memory pattern regulate HDAC4 to promote apoptosis in rat hippocampal neurons.
Xu Y, Wei S, Zhu L, Huang C, Yang T, Wang S, Zhang Y, Duan Y, Li X, Wang Z, Pan W
Ecotoxicology and environmental safety 2023 Mar 15;253:114660
Ecotoxicology and environmental safety 2023 Mar 15;253:114660
Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis.
Lax A, Soler F, Fernandez Del Palacio MJ, Pascual-Oliver S, Ballester MR, Fuster JJ, Pascual-Figal D, Asensio-Lopez MDC
Molecular therapy. Nucleic acids 2023 Jun 13;32:704-720
Molecular therapy. Nucleic acids 2023 Jun 13;32:704-720
Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells.
Wang L, Liu L, Han C, Jiang H, Ma K, Guo S, Xia Y, Wan F, Huang J, Xiong N, Wang T
Brain sciences 2023 Apr 16;13(4)
Brain sciences 2023 Apr 16;13(4)
Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.
He X, Sun T, Zhang P, Xia Z, Gao C, Ren H, Ji D
Frontiers in medicine 2022;9:848938
Frontiers in medicine 2022;9:848938
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis.
Wang T, Lu Z, Han T, Wang Y, Gan M, Wang JB
International journal of biological sciences 2022;18(11):4452-4465
International journal of biological sciences 2022;18(11):4452-4465
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Feng Y, Ma Z, Pan M, Xu L, Feng J, Zhang Y, Shao C, Guo K, Duan H, Zhang Y, Zhang Y, Zhang J, Lu D, Ren X, Han J, Li X, Yan X
Cell death & disease 2022 May 20;13(5):480
Cell death & disease 2022 May 20;13(5):480
Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.
Jiang A, Guo H, Zhang L, Jiang X, Zhang X, Wu W, Liu H
Molecular and cellular biology 2022 Jan 20;42(1):e0032721
Molecular and cellular biology 2022 Jan 20;42(1):e0032721
Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.
Shao C, Guo K, Xu L, Zhang Y, Duan H, Feng Y, Pan M, Lu D, Ren X, Ganti AK, Hakozaki T, Han J, Yan X, Ma Z
Translational lung cancer research 2021 Dec;10(12):4558-4573
Translational lung cancer research 2021 Dec;10(12):4558-4573
Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.
Mou Z, Yang C, Zhang Z, Wu S, Xu C, Cheng Z, Dai X, Chen X, Ou Y, Jiang H
Frontiers in genetics 2020;11:566918
Frontiers in genetics 2020;11:566918
Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.
Guo Q, Wang T, Yang Y, Gao L, Zhao Q, Zhang W, Xi T, Zheng L
Molecular therapy. Nucleic acids 2020 Sep 4;21:527-541
Molecular therapy. Nucleic acids 2020 Sep 4;21:527-541
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.
Shi W, Huang Y, Zhao X, Xie Z, Dong W, Li R, Chen Y, Li Z, Wang W, Ye Z, Liu S, Zhang L, Liang X
Biochemical and biophysical research communications 2020 Dec 17;533(4):1061-1068
Biochemical and biophysical research communications 2020 Dec 17;533(4):1061-1068
Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4.
Zhao H, Shu L, Huang W, Song G, Ma H
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:401-411
Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival.
Wang Z, Wang H, Shen P, Xie R
Annals of clinical and laboratory science 2019 Mar;49(2):189-192
Annals of clinical and laboratory science 2019 Mar;49(2):189-192
TMCO1-mediated Ca(2+) leak underlies osteoblast functions via CaMKII signaling.
Li J, Liu C, Li Y, Zheng Q, Xu Y, Liu B, Sun W, Li Y, Ji S, Liu M, Zhang J, Zhao D, Du R, Liu Z, Zhong G, Sun C, Wang Y, Song J, Zhang S, Qin J, Ling S, Wang X, Li Y
Nature communications 2019 Apr 8;10(1):1589
Nature communications 2019 Apr 8;10(1):1589
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.
He B, Dai L, Zhang X, Chen D, Wu J, Feng X, Zhang Y, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2018;14(13):1845-1858
International journal of biological sciences 2018;14(13):1845-1858
Hyper-acetylation contributes to the sensitivity of chemo-resistant prostate cancer cells to histone deacetylase inhibitor Trichostatin A.
Xu Q, Liu X, Zhu S, Hu X, Niu H, Zhang X, Zhu D, Nesa EU, Tian K, Yuan H
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922
Journal of cellular and molecular medicine 2018 Mar;22(3):1909-1922
Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.
Li Y, Li L, Qian Z, Lin B, Chen J, Luo Y, Qu J, Raj JU, Gou D
Journal of the American Heart Association 2018 Mar 7;7(6)
Journal of the American Heart Association 2018 Mar 7;7(6)
Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.
Niu Y, Wang T, Liu S, Yuan H, Li H, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2372-2381
Biochimica et biophysica acta. Molecular basis of disease 2017 Sep;1863(9):2372-2381
Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.
Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Cancer biology & therapy 2016 Nov;17(11):1117-1125
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y, Jin J
International journal of oncology 2015;46(6):2535-45
International journal of oncology 2015;46(6):2535-45
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.
Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1237-48
Hepatology (Baltimore, Md.) 2015 Oct;62(4):1237-48
Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.
Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92
Oncology reports 2015 Feb;33(2):685-92
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
MicroRNA directly enhances mitochondrial translation during muscle differentiation.
Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD
Cell 2014 Jul 31;158(3):607-19
Cell 2014 Jul 31;158(3):607-19
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.
He M, Zhang B, Wei X, Wang Z, Fan B, Du P, Zhang Y, Jian W, Chen L, Wang L, Fang H, Li X, Wang PA, Yi F
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17449-1-AP(HDAC4 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC4. This antibody recognizes human,mouse,rat antigen. The HDAC4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
