12433-1-AP

antibody from Proteintech Group

Targeting: HOMER1 HOMER-1B, SYN47, Ves-1

Provider product page for 12433-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [26]
Comments [0]
Validations
Western blot [1]
Flow cytometry [1]

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Product number: 12433-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12433-1-AP, RRID:AB_2295573
Product name: HOMER1 antibody
Antibody type: Polyclonal
Description: HOMER1 antibody (Cat. #12433-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HOMER1 protein structure - 12433-1-AP shown in red.

Submitted references Neuron-glioma synaptic transmission amplified by free 19S proteasome-mediated AMPAR deubiquitination promotes tumor progression.

Lu Y, Liu X, Wang K, Wang Z, Shen L, Yuan S, Zhang Z, Qian J
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00847

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise-Induced Hearing Loss.

Chen P, Che C, Wu L, Sun C, Xu D, Hua Q, Zhang Y, Tang YQ, Shi P, Sun S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e08466

Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution.

Ciuba K, Piotrowska A, Chaudhury D, Dehingia B, Duński E, Behr R, Soroczyńska K, Czystowska-Kuźmicz M, Abbas M, Bulanda E, Gawlik-Zawiślak S, Pietrzak S, Figiel I, Włodarczyk J, Verkhratsky A, Niedbała M, Kaspera W, Wypych T, Wilczyński B, Pękowska A
Cell stem cell 2025 Mar 6;32(3):426-444.e14

Enhanced Pain Sensitization Induced by Chronic Sleep Deprivation: The Role of Dopamine D2 Receptors-Dependent Homer1a Protein.

Fu C, Wu P, Wu F, He W, Luo Q, Liang H, Wang H, Li Y
ACS chemical neuroscience 2025 Mar 19;16(6):1043-1054

Obacunone Alleviates Thalamic Pain via Promoting LCN2-Mediated Phagocytosis of Astrocytes in Mice.

Li YR, Xie LL, Cai HB, Dang ZH, Li LL, Wang X, Lu YW, Zhang ZC, Gao S, Liu JY, Xu LS, Feng QL, Qin XD, Bu F
ACS chemical neuroscience 2025 Jul 2;16(13):2546-2558

DNA2 knockout aggravates cerebral ischemia/reperfusion injury by reducing postsynaptic Homer1a.

Ma T, Li YM, Ren PY, Wang SQ, Liu XL, Lv WB, Hou WG, Zuo WQ, Lin WQ, Sima J, Geng AQ
Zoological research 2025 Jan 18;46(1):87-102

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons.

Sun SY, Nie L, Zhang J, Fang X, Luo H, Fu C, Wei Z, Tang AH
Neural regeneration research 2025 Jan 1;20(1):209-223

Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice.

Wang J, Zhang J, Li J, Gao Q, Chen J, Jia C, Gu X
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Feb 26;45(9)

Astrocyte TrkB.T1 deficiency disrupts glutamatergic synaptogenesis and astrocyte-synapse interactions.

Pinkston BTC, Browning JL, Olsen ML
bioRxiv : the preprint server for biology 2024 Oct 22;

Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.

Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
Nature neuroscience 2024 May;27(5):822-835

Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling.

Zhang Y, Li S, Li L, Huang H, Fu Z, Hua Z
In vitro cellular & developmental biology. Animal 2024 Mar;60(2):161-171

Human induced pluripotent stem cell/embryonic stem cell-derived pyramidal neuronal precursors show safety and efficacy in a rat spinal cord injury model.

Li M, Qi B, Li Q, Zheng T, Wang Y, Liu B, Guan Y, Bai Y, Jian F, Xu ZD, Xu Q, Chen Z
Cellular and molecular life sciences : CMLS 2024 Jul 29;81(1):318

Ndufa4 Regulates the Proliferation and Apoptosis of Neurons via miR-145a-5p/Homer1/Ccnd2.

Fu F, Chen C, Du K, Li LS, Li R, Lei TY, Deng Q, Wang D, Yu QX, Yang X, Han J, Pan M, Zhen L, Zhang LN, Li J, Li FT, Zhang YL, Jing XY, Li FC, Li DZ, Liao C
Molecular neurobiology 2023 Jun;60(6):2986-3003

Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.

Wang Y, Li Y, Wang G, Lu J, Li Z
CNS neuroscience & therapeutics 2023 Jan;29(1):331-343

Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy.

Zhang Q, Miyamoto A, Watanabe S, Arimori T, Sakai M, Tomisaki M, Kiuchi T, Takagi J, Watanabe N
Cell reports methods 2022 Oct 24;2(10):100301

A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

Qin Y, Du Y, Chen L, Liu Y, Xu W, Liu Y, Li Y, Leng J, Wang Y, Zhang XY, Feng J, Zhang F, Jin L, Qiu Z, Gong X, Wang H
Molecular psychiatry 2022 Jul;27(7):2985-2998

sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway.

Lu L, Liu X, Fu J, Liang J, Hou Y, Dou H
Scientific reports 2022 Apr 29;12(1):7047

Social context-dependent singing alters molecular markers of synaptic plasticity signaling in finch basal ganglia Area X.

So LY, Miller JE
Behavioural brain research 2021 Feb 1;398:112955

Liraglutide preconditioning attenuates myocardial ischemia/ reperfusion injury via homer1 activation.

Cui X, Liang H, Hao C, Jing X
Aging 2021 Feb 1;13(5):6625-6633

Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.

Chen C, Soto G, Dumrongprechachan V, Bannon N, Kang S, Kozorovitskiy Y, Parisiadou L
eLife 2020 Oct 2;9

Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.

Reibring CG, Hallberg K, Linde A, Gritli-Linde A
International journal of molecular sciences 2020 Feb 13;21(4)

A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation.

Ogundele OM, Pardo J, Francis J, Goya RG, Lee CC
Frontiers in neuroanatomy 2018;12:35

Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.

El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A
PLoS genetics 2017 Jul;13(7):e1006914

Acid-sensing ion channels activation and hypoxia upregulate Homer1a expression.

Su JJ, Pan H, Zhou HG, Tang YP, Dong Q, Liu JR
CNS neuroscience & therapeutics 2014 Mar;20(3):264-74

Lithium attenuates scopolamine-induced memory deficits with inhibition of GSK-3β and preservation of postsynaptic components.

Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ, Zhu LQ
Journal of Alzheimer's disease : JAD 2013;37(3):515-27

Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c.

Su J, Tang Y, Zhou H, Liu L, Dong Q
Cellular signalling 2012 Nov;24(11):2205-15

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 12433-1-AP(HOMER1 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The HOMER1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HOMER1. This antibody recognizes human,mouse,rat antigen. The HOMER1 antibody has been validated for the following applications: ELISA, IHC, WB, FC analysis.
Appendix: 12433-1-AP.pdf

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