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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB230A-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human IL-4R alpha APC-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human IL-4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha , rhIL-5 R beta , rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Antigen sequence
P24394- Isotype
- IgG
- Antibody clone number
- 25463
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Enhancing the Potency and Specificity of Engineered T Cells for Cancer Treatment.
4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells.
The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.
Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients.
Absence of a role for interleukin-13 in inflammatory bowel disease.
Sukumaran S, Watanabe N, Bajgain P, Raja K, Mohammed S, Fisher WE, Brenner MK, Leen AM, Vera JF
Cancer discovery 2018 Aug;8(8):972-987
Cancer discovery 2018 Aug;8(8):972-987
4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells.
Zilio S, Vella JL, De la Fuente AC, Daftarian PM, Weed DT, Kaifer A, Marigo I, Leone K, Bronte V, Serafini P
Journal of immunology (Baltimore, Md. : 1950) 2017 May 15;198(10):4166-4177
Journal of immunology (Baltimore, Md. : 1950) 2017 May 15;198(10):4166-4177
The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.
Warren KJ, Fang X, Gowda NM, Thompson JJ, Heller NM
The Journal of biological chemistry 2016 Nov 25;291(48):24922-24930
The Journal of biological chemistry 2016 Nov 25;291(48):24922-24930
Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients.
Bailur JK, Gueckel B, Derhovanessian E, Pawelec G
Breast cancer research : BCR 2015 Mar 10;17:34
Breast cancer research : BCR 2015 Mar 10;17:34
Absence of a role for interleukin-13 in inflammatory bowel disease.
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza GR, MacDonald TT
European journal of immunology 2014 Feb;44(2):370-85
European journal of immunology 2014 Feb;44(2):370-85
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Detection of IL-4 R alpha in Daudi Human Cell Line by Flow Cytometry. Daudi human Burkitt's lymphoma cell line was stained with Mouse Anti-Human IL-4 R alpha APC-conjugated Monoclonal Antibody (Catalog # FAB230A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.
