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- Antigen structure
- References [7]
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- Product number
- 16-0157-85 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IL-15 Monoclonal Antibody (ct2nu), Functional Grade, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- Description: The ct2nu monoclonal antibody reacts with human IL-15 and neutralizes its bioactivity. IL-15, or IL-T, is a 14 kDa proinflammatory cytokine and member of the IL-2 family. It plays a role in the development and maturation of macrophages and dendritic cells, and is essential to the proliferation and survival of NK cells and CD8^+ T cells.
- Antibody clone number
- ct2nu
- Concentration
- 1 mg/mL
Submitted references Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens.
Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions.
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.
Interleukin 15: biology and relevance to human disease.
Mysore V, Cullere X, Settles ML, Ji X, Kattan MW, Desjardins M, Durbin-Johnson B, Gilboa T, Baden LR, Walt DR, Lichtman AH, Jehi L, Mayadas TN
Med (New York, N.Y.) 2021 Sep 10;2(9):1050-1071.e7
Med (New York, N.Y.) 2021 Sep 10;2(9):1050-1071.e7
Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens.
Mysore V, Cullere X, Settles ML, Ji X, Kattan MW, Desjardins M, Durbin-Johnson B, Gilboa T, Baden LR, Walt DR, Lichtman A, Jehi L, Mayadas TN
bioRxiv : the preprint server for biology 2021 May 4;
bioRxiv : the preprint server for biology 2021 May 4;
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, McEwen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A
Nature 2021 Dec;600(7888):295-301
Nature 2021 Dec;600(7888):295-301
IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions.
Sattler A, Dang-Heine C, Reinke P, Babel N
European journal of immunology 2015 Aug;45(8):2286-98
European journal of immunology 2015 Aug;45(8):2286-98
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
Huntington ND, Legrand N, Alves NL, Jaron B, Weijer K, Plet A, Corcuff E, Mortier E, Jacques Y, Spits H, Di Santo JP
The Journal of experimental medicine 2009 Jan 16;206(1):25-34
The Journal of experimental medicine 2009 Jan 16;206(1):25-34
Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.
Rowley J, Monie A, Hung CF, Wu TC
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 15;181(12):8237-47
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 15;181(12):8237-47
Interleukin 15: biology and relevance to human disease.
Fehniger TA, Caligiuri MA
Blood 2001 Jan 1;97(1):14-32
Blood 2001 Jan 1;97(1):14-32
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Neutralization of Human IL-15 Recombinant Protein activity, as measured by CTLL-2 proliferation.
