MAB247

antibody from R&D Systems

Targeting: IL15 IL-15, MGC9721

Western blot (Recommended by provider)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

MAB247

Provider

R&D Systems

Product name

Anti-Human IL-15 Monoclonal Antibody (Clone 34593)

Antibody type

Monoclonal

Antigen

E. coli-derived recombinant human IL-15, Asn49-Ser162

Description

Protein A or G purified from ascites

Reactivity

Human

Host

Mouse

Antigen sequence

P40933


Isotype

IgG

Vial size

500 µg

References

Submitted references

Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.

Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, Azimi N, Tagaya Y
The Journal of biological chemistry 2015 Sep 11;290(37):22338-51

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IL-15 expression on RA synovial fibroblasts promotes B cell survival.

Benito-Miguel M, García-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibáñez T, Bonilla-Hernán MG, Pérez de Ayala C, Sánchez-Mateos P, Martín-Mola E, Miranda-Carús ME
PloS one 2012;7(7):e40620

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Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.

Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y
Blood 2011 Apr 14;117(15):4032-40

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TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA.

Perrot I, Deauvieau F, Massacrier C, Hughes N, Garrone P, Durand I, Demaria O, Viaud N, Gauthier L, Blery M, Bonnefoy-Berard N, Morel Y, Tschopp J, Alexopoulou L, Trinchieri G, Paturel C, Caux C
Journal of immunology (Baltimore, Md. : 1950) 2010 Aug 15;185(4):2080-8

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Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils.

Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD
Arthritis and rheumatism 2006 Jul;54(7):2096-108

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Cloning and expression of feline interleukin 15.

Dean GA, Barger A, Lavoy A
Cytokine 2005 Jan 21;29(2):77-83

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Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.

Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Münz C
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 23;101(47):16606-11

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IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.

Miranda-Carús ME, Balsa A, Benito-Miguel M, Pérez de Ayala C, Martín-Mola E
Journal of immunology (Baltimore, Md. : 1950) 2004 Jul 15;173(2):1463-76

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IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.

Miranda-Carús ME, Balsa A, Benito-Miguel M, Pérez de Ayala C, Martín-Mola E
Journal of immunology (Baltimore, Md. : 1950) 2004 Jul 15;173(2):1463-76

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Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.

Briard D, Brouty-Boyé D, Azzarone B, Jasmin C
Journal of immunology (Baltimore, Md. : 1950) 2002 May 1;168(9):4326-32

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Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.

Briard D, Brouty-Boyé D, Azzarone B, Jasmin C
Journal of immunology (Baltimore, Md. : 1950) 2002 May 1;168(9):4326-32

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Regulatory activity of autocrine IL-10 on dendritic cell functions.

Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G
Journal of immunology (Baltimore, Md. : 1950) 2001 Apr 1;166(7):4312-8

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Regulatory activity of autocrine IL-10 on dendritic cell functions.

Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G
Journal of immunology (Baltimore, Md. : 1950) 2001 Apr 1;166(7):4312-8