Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 10478-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10478-2-AP, RRID:AB_2126032
- Product name
- IRAK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IRAK1 antibody (Cat. #10478-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references IRAK1 deficiency potentiates the efficacy of radiotherapy in repressing cervical cancer development.
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2.
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis.
MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway.
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Sea Cucumber Hydrolysate Alleviates Immunosuppression and Gut Microbiota Imbalance Induced by Cyclophosphamide in Balb/c Mice through the NF-κB Pathway.
Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy.
miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway.
Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals.
Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.
Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis.
Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling.
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity.
MiR-146a mediates TLR-4 signaling pathway to affect myocardial fibrosis in rat constrictive pericarditis model.
Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization.
S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1.
A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages.
Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS.
Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.
Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD.
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis.
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages.
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality.
Chen W, Xie X, Liu C, Liao J, Wei Y, Wu R, Hong J
Cellular signalling 2024 Jul;119:111192
Cellular signalling 2024 Jul;119:111192
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2.
Li Z, Liu B, Lambertsen KL, Clausen BH, Zhu Z, Du X, Xu Y, Poulsen FR, Halle B, Bonde C, Chen M, Wang X, Schlüter D, Huang J, Waisman A, Song W, Wang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(28):e2301641
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(28):e2301641
METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling.
Luo S, Liao C, Zhang L, Ling C, Zhang X, Xie P, Su G, Chen Z, Zhang L, Lai T, Tang J
Cell reports 2023 Mar 28;42(3):112259
Cell reports 2023 Mar 28;42(3):112259
Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis.
Xu X, Wei Y, Pang J, Wei Z, Wang L, Chen Q, Wang Z, Zhang Y, Chen K, Peng Y, Zhang Z, Liu J, Zhang Y, Jin ZB, Liang Q
Investigative ophthalmology & visual science 2023 Mar 1;64(3):6
Investigative ophthalmology & visual science 2023 Mar 1;64(3):6
MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway.
Wang L, Wang X, Chen Q, Wei Z, Xu X, Han D, Zhang Y, Chen Z, Liang Q
The ocular surface 2023 Apr;28:131-140
The ocular surface 2023 Apr;28:131-140
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259
Cell death & disease 2023 Apr 8;14(4):259
Sea Cucumber Hydrolysate Alleviates Immunosuppression and Gut Microbiota Imbalance Induced by Cyclophosphamide in Balb/c Mice through the NF-κB Pathway.
Mao J, Li S, Fu R, Wang Y, Meng J, Jin Y, Wu T, Zhang M
Foods (Basel, Switzerland) 2023 Apr 10;12(8)
Foods (Basel, Switzerland) 2023 Apr 10;12(8)
Folic acid ameliorates alcohol-induced liver injury via gut-liver axis homeostasis.
Zhang H, Zuo Y, Zhao H, Zhao H, Wang Y, Zhang X, Zhang J, Wang P, Sun L, Zhang H, Liang H
Frontiers in nutrition 2022;9:989311
Frontiers in nutrition 2022;9:989311
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Xu BL, Wang YY, Jiang LL, Liu Z, Liu DR, Zhao H, Li SL, Wang XB
Frontiers in pharmacology 2022;13:1096137
Frontiers in pharmacology 2022;13:1096137
c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy.
Hou W, Lu L, Li X, Sun M, Zhu M, Miao C
Cellular signalling 2022 Apr;92:110263
Cellular signalling 2022 Apr;92:110263
miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-κB Signaling Pathway.
Liu T, Wu DM, Zhang F, Zhang T, He M, Zhao YY, Li J, Li L, Xu Y
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1256-1268
International journal of radiation oncology, biology, physics 2022 Apr 1;112(5):1256-1268
Shenjinhuoxue Mixture Attenuates Inflammation, Pain, and Cartilage Degeneration by Inhibiting TLR-4 and NF-κB Activation in Rats with Osteoarthritis: A Synergistic Combination of Multitarget Active Phytochemicals.
Ma X, Hao C, Zhang Z, Jiang H, Zhang W, Huang J, Chen X, Yang W
Oxidative medicine and cellular longevity 2021;2021:4190098
Oxidative medicine and cellular longevity 2021;2021:4190098
Morchella importuna Flavones Improve Intestinal Integrity in Dextran Sulfate Sodium-Challenged Mice.
Xu Y, Xie L, Tang J, He X, Zhang Z, Chen Y, Zhou J, Gan B, Peng W
Frontiers in microbiology 2021;12:742033
Frontiers in microbiology 2021;12:742033
Bone marrow mesenchymal stem cell-derived exosomes induce the Th17/Treg imbalance in immune thrombocytopenia through miR-146a-5p/IRAK1 axis.
He Y, Ji D, Lu W, Li F, Huang X, Huang R, Chen G
Human cell 2021 Sep;34(5):1360-1374
Human cell 2021 Sep;34(5):1360-1374
Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling.
Li H, Peng Y, Lin C, Zhang X, Zhang T, Wang Y, Li Y, Wu S, Wang H, Hutchinson MR, Watkins LR, Wang X
Innovation (Cambridge (Mass.)) 2021 May 28;2(2):100111
Innovation (Cambridge (Mass.)) 2021 May 28;2(2):100111
Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.
Xu G, Deng F, Zuo Q, Liu L, Dou K, Cheng Z, Cao W, Luo C, Yu C, Liu S, Zhu Y
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
Cellular & molecular immunology 2021 Jun;18(6):1587-1589
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schlüter D
Cellular & molecular immunology 2021 Jun;18(6):1512-1527
Cellular & molecular immunology 2021 Jun;18(6):1512-1527
Cannabidiol-dihydroartemisinin conjugates for ameliorating neuroinflammation with reduced cytotoxicity.
Wang F, Li M, Lin C, Jin S, Li H, Lu Y, Wang H, Wang H, Wang X
Bioorganic & medicinal chemistry 2021 Jun 1;39:116131
Bioorganic & medicinal chemistry 2021 Jun 1;39:116131
MiR-146a mediates TLR-4 signaling pathway to affect myocardial fibrosis in rat constrictive pericarditis model.
Xiao Y, Qiao W, Wang X, Sun L, Ren W
Journal of thoracic disease 2021 Feb;13(2):935-945
Journal of thoracic disease 2021 Feb;13(2):935-945
Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization.
Duan S, Wang F, Cao J, Wang C
Drug design, development and therapy 2020;14:3143-3158
Drug design, development and therapy 2020;14:3143-3158
S100A14 suppresses metastasis of nasopharyngeal carcinoma by inhibition of NF-kB signaling through degradation of IRAK1.
Meng DF, Sun R, Liu GY, Peng LX, Zheng LS, Xie P, Lin ST, Mei Y, Qiang YY, Li CZ, Xu L, Peng XS, Hu H, Lang YH, Liu ZJ, Wang MD, Guo LL, Xie DH, Shu DT, Li HF, Luo FF, Niu XT, Huang BJ, Qian CN
Oncogene 2020 Jul;39(30):5307-5322
Oncogene 2020 Jul;39(30):5307-5322
A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages.
Deng F, He S, Cui S, Shi Y, Tan Y, Li Z, Huang C, Liu D, Zhi F, Peng L
Journal of Crohn's & colitis 2019 Mar 30;13(4):482-494
Journal of Crohn's & colitis 2019 Mar 30;13(4):482-494
Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS.
Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1054-1069
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1054-1069
Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome.
Hu Y, Li Q, Pan Y, Xu L
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)
Molecules (Basel, Switzerland) 2019 Dec 3;24(23)
Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD.
He S, Guo W, Deng F, Chen K, Jiang Y, Dong M, Peng L, Chen X
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):217-228
Artificial cells, nanomedicine, and biotechnology 2018;46(sup2):217-228
Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells.
Jiang Z, Song F, Li Y, Xue D, Deng G, Li M, Liu X, Wang Y
Mediators of inflammation 2017;2017:9891673
Mediators of inflammation 2017;2017:9891673
Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis.
Zhou Q, Lin FF, Liu SM, Sui XF
Journal of ethnopharmacology 2017 Jul 12;206:274-282
Journal of ethnopharmacology 2017 Jul 12;206:274-282
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
Yao H, Hu C, Yin L, Tao X, Xu L, Qi Y, Han X, Xu Y, Zhao Y, Wang C, Peng J
International immunopharmacology 2016 Jul;36:132-141
International immunopharmacology 2016 Jul;36:132-141
Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages.
Jiang M, Xiang Y, Wang D, Gao J, Liu D, Liu Y, Liu S, Zheng D
Aging cell 2012 Feb;11(1):29-40
Aging cell 2012 Feb;11(1):29-40
Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality.
Sun Y, Varambally S, Maher CA, Cao Q, Chockley P, Toubai T, Malter C, Nieves E, Tawara I, Wang Y, Ward PA, Chinnaiyan A, Reddy P
Blood 2011 Jun 9;117(23):6172-83
Blood 2011 Jun 9;117(23):6172-83
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IRAK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IRAK1. This antibody recognizes human,mouse,rat antigen. The IRAK1 antibody has been validated for the following applications: ELISA, WB analysis.