Antibody data

Product number
BS4698 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IRAK1 (phospho T209) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Threonine 209.
Description
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1Ï« and IL-1ÉÇ, and a specific receptor antagonist, IL-1RÏ«. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NF°ÙB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NF°ÙB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NF°ÙB.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IRAK1 protein structure - BS4698 shown in red.