24164-1-AP

antibody from Proteintech Group

Targeting: MAPK8 JNK, JNK1, PRKM8, SAPK1

Provider product page for 24164-1-AP

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Immunohistochemistry

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Antibody Data
Antigen structure
References [56]
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Immunohistochemistry [1]

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Product number: 24164-1-AP - Provider product page
Provider: Proteintech Group
Product name: JNK antibody
Antibody type: Polyclonal
Description: JNK antibody (Cat. #24164-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAPK8 protein structure - 24164-1-AP shown in red.

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Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094

Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways.

Shen Y, Teng L, Qu Y, Liu J, Zhu X, Chen S, Yang L, Huang Y, Song Q, Fu Q
Journal of ethnopharmacology 2022 Feb 10;284:114791

RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway.

Zhang D, Jiang Q, Ge X, Shi Y, Ye T, Mi Y, Xie T, Li Q, Ye Q
International journal of biological sciences 2021;17(10):2622-2632

tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway.

Xu W, Zhou B, Wang J, Tang L, Hu Q, Wang J, Chen H, Zheng J, Yan F, Chen H
Frontiers in oncology 2021;11:733763

Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF.

Zhao J, Qu D, Xi Z, Huan Y, Zhang K, Yu C, Yang D, Kang J, Lin W, Wu S, Wang Y
Translational research : the journal of laboratory and clinical medicine 2021 Sep;235:102-114

Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor.

Yuan S, Zheng S, Zheng K, Gao Y, Chen M, Li Y, Bai X
Stem cell research & therapy 2021 Sep 16;12(1):505

[8]-Gingerol exerts anti-myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L-type Ca(2+) channels.

Xue Y, Zhang M, Zheng B, Zhang Y, Chu X, Liu Y, Li Z, Han X, Chu L
Pharmacology research & perspectives 2021 Oct;9(5):e00852

Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis.

Liu S, Gu L, Wu N, Song J, Yan J, Yang S, Feng Y, Wang Z, Wang L, Zhang Y, Jin Y
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Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

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Journal of clinical laboratory analysis 2021 Nov 26;:e24019

Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.

Jia X, Zhu H, Li G, Lan M, Li X, Huang M, Xu W, Wu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111321

ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes.

Lai X, Wang M, Zhu Y, Feng X, Liang H, Wu J, Nie L, Li L, Shao L
Journal of hazardous materials 2021 May 15;410:124566

PM2.5 exposure induces reproductive injury through IRE1/JNK/autophagy signaling in male rats.

Yang Y, Feng Y, Huang H, Cui L, Li F
Ecotoxicology and environmental safety 2021 Mar 15;211:111924

A human β-casein-derived peptide BCCY-1 modulates the innate immune response.

Cai J, Li X, Wang X, Jiang C, Shen D, Cui X, Xie K, Ji C, Cao Y
Food chemistry 2021 Jun 30;348:129111

Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.

Zhang W, Zhu Y, Yu H, Liu X, Jiao B, Lu X
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)

Nephrotoxicity and possible mechanisms of decabrominated diphenyl ethers (BDE-209) exposure to kidney in broilers.

Sun S, Jin Y, Yang J, Zhao Z, Rao Q
Ecotoxicology and environmental safety 2021 Jan 15;208:111638

G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.

Liu Y, Deng J, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111925

Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice.

Wang X, Cheng K, Liu Z, Sun Y, Zhou L, Xu M, Dai X, Xiong Y, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153804

Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways.

Wang X, Chen S, Zhao L, Shi X
International immunopharmacology 2021 Aug;97:107506

Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice.

Cai G, Wu Y, Wusiman A, Gu P, Mao N, Xu S, Zhu T, Feng Z, Liu Z, Wang D
Food & function 2021 Aug 2;12(15):6863-6877

Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.

Zhou S, He Y, Zhang W, Xiong Y, Jiang L, Wang J, Cui X, Qu Y, Ge F
Journal of ethnopharmacology 2021 Aug 10;276:114189

Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.

Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885

Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus.

Lv W, Graves DT, He L, Shi Y, Deng X, Zhao Y, Dong X, Ren Y, Liu X, Xiao E, Zhang Y
Theranostics 2020;10(14):6500-6516

Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.

An K, Zhang Y, Liu Y, Yan S, Hou Z, Cao M, Liu G, Dong C, Gao J, Liu G
Oncology reports 2020 Sep;44(3):1116-1126

Grape Seed Proanthocyanidins Induce Apoptosis and Cell Cycle Arrest of HepG2 Cells Accompanied by Induction of the MAPK Pathway and NAG-1.

Wang L, Zhan J, Huang W
Antioxidants (Basel, Switzerland) 2020 Nov 28;9(12)

In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling.

Wu Z, Cheng Y, Yang Y, Gao Y, Sun X, Wang L, Sun Q, Zhang J, Xu X
International journal of biological macromolecules 2020 May 1;150:802-813

Resveratrol-loaded biopolymer core-shell nanoparticles: bioavailability and anti-inflammatory effects.

Liu Y, Liang X, Zou Y, Peng Y, McClements DJ, Hu K
Food & function 2020 May 1;11(5):4014-4025

Antioxidants suppress radiation-induced apoptosis via inhibiting MAPK pathway in nasopharyngeal carcinoma cells.

Meng DF, Guo LL, Peng LX, Zheng LS, Xie P, Mei Y, Li CZ, Peng XS, Lang YH, Liu ZJ, Wang MD, Xie DH, Shu DT, Hu H, Lin ST, Li HF, Luo FF, Sun R, Huang BJ, Qian CN
Biochemical and biophysical research communications 2020 Jun 30;527(3):770-777

Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway.

Fang H, Yang K, Tang P, Zhao N, Ma R, Luo X, Liu Q
Aging 2020 Jun 30;12(13):12850-12868

Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway.

Yu T, Dong D, Guan J, Sun J, Guo M, Wang Q
Herz 2020 Dec;45(Suppl 1):130-138

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.

Pu ZQ, Liu D, Lobo Mouguegue HPP, Jin CW, Sadiq E, Qin DD, Yu TF, Zong C, Chen JC, Zhao RX, Lin JY, Cheng J, Yu X, Li X, Zhang YC, Liu YT, Guan QB, Wang XD
Journal of cellular and molecular medicine 2020 Dec;24(24):14171-14183

IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

Wang M, Guo J, Zhao YQ, Wang JP
Aging 2020 Aug 28;12(16):16099-16110

Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.

Wang W, Wu L, Li J, Ji J, Chen K, Yu Q, Li S, Feng J, Liu T, Zhang J, Chen J, Zhou Y, Mao Y, Wang F, Dai W, Fan X, Guo C, Wu J
Mediators of inflammation 2019;2019:3240713

The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.

Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)

Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.

Li M, Hao S, Li C, Xiao H, Sun L, Yu Z, Zhang N, Xiong Y, Zhao D, Yin Y
Biomolecules 2019 Sep 19;9(9)

MCP-induced protein 1 attenuates sepsis-induced acute lung injury by modulating macrophage polarization via the JNK/c-Myc pathway.

Zhang Y, Huang T, Jiang L, Gao J, Yu D, Ge Y, Lin S
International immunopharmacology 2019 Oct;75:105741

Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop.

Liang S, Wang ZG, Zhang ZZ, Chen K, Lv ZT, Wang YT, Cheng P, Sun K, Yang Q, Chen AM
Aging 2019 Oct 11;11(19):8664-8680

Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells.

Zhang C, Wu Q, Huang H, Chen X, Huang T, Li W, Liu Y, Zhang J
Journal of physiology and biochemistry 2019 Nov;75(4):549-559

Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma.

Zhang C, Huang H, Zhang J, Wu Q, Chen X, Huang T, Li W, Liu Y, Zhang J
Cell death & disease 2019 Jun 17;10(7):477

Effect of CAPE-pNO₂ against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice.

Li S, Huang Q, Zhang L, Qiao X, Zhang Y, Tang F, Li Z
European journal of pharmacology 2019 Jun 15;853:1-10

Small molecule inhibitor of TGF-β signaling enables robust osteogenesis of autologous GMSCs to successfully repair minipig severe maxillofacial bone defects.

Shi A, Heinayati A, Bao D, Liu H, Ding X, Tong X, Wang L, Wang B, Qin H
Stem cell research & therapy 2019 Jun 13;10(1):172

Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.

Tian L, Su CP, Wang Q, Wu FJ, Bai R, Zhang HM, Liu JY, Lu WJ, Wang W, Lan F, Guo SZ
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678

Amyloid-β_1-42 dynamically regulates the migration of neural stem/progenitor cells via MAPK-ERK pathway.

Wang Z, Chen Y, Li X, Sultana P, Yin M, Wang Z
Chemico-biological interactions 2019 Jan 25;298:96-103

Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.

Sun J, Ren XS, Kang Y, Dai HB, Ding L, Tong N, Zhu GQ, Zhou YB
Neuroscience bulletin 2019 Feb;35(1):34-46

Sigma-1 receptor protects against endoplasmic reticulum stress-mediated apoptosis in mice with cerebral ischemia/reperfusion injury.

Zhao X, Zhu L, Liu D, Chi T, Ji X, Liu P, Yang X, Tian X, Zou L
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):157-167

Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice.

Ren Z, Chen L, Wang Y, Wei X, Zeng S, Zheng Y, Gao C, Liu H
Journal of immunology (Baltimore, Md. : 1950) 2019 Feb 1;202(3):747-759

Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation.

Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L
Yonsei medical journal 2019 Dec;60(12):1195-1202

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury.

Su L, Jiang X, Yang C, Zhang J, Chen B, Li Y, Yao S, Xie Q, Gomez H, Murugan R, Peng Z
The Journal of biological chemistry 2019 Dec 13;294(50):19395-19404

The IRE1 signaling pathway is involved in the protective effect of low-dose LPS on myocardial ischemia-reperfusion injury.

Wu T, Jiang N, Ji Z, Shi G
Life sciences 2019 Aug 15;231:116569

Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.

Ren D, Zhao Y, Zheng Q, Alim A, Yang X
Food & function 2019 Apr 1;10(4):2186-2197

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.

Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378

Apoptosis of bone marrow mesenchymal stromal/stem cells via the MAPK and endoplasmic reticulum stress signaling pathways.

Chen T, Zhu H, Wang Y, Zhao P, Chen J, Sun J, Zhang X, Zhu G
American journal of translational research 2018;10(8):2555-2566

Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.

Wang Z, Ren J, Liu Q, Li J, Wu X, Wang W, Wu J, Wang G, Li J
Thrombosis research 2018 Nov;171:45-54

IL-1β promotes the migration of olfactory epithelium neural stem cells through activating matrix metalloproteinase expressions.

Pu Y, Liu H, Xu H, Liu H, Cheng Y, Chen X, Xu W, Xu Y, Fan J
Pathology, research and practice 2018 Aug;214(8):1210-1217

Hepatoprotective effect of quercetin against LPS/d-GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways.

Peng Z, Gong X, Yang Y, Huang L, Zhang Q, Zhang P, Wan R, Zhang B
International immunopharmacology 2017 Nov;52:281-289

A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway.

Sun L, Xu C, Chen G, Yu M, Yang S, Qiu Y, Peng K, Wang W, Xiao W, Yang H
International journal of biological sciences 2015;11(6):664-71

Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells.

Wu T, Li Y, Huang D, Han F, Zhang YY, Zhang DW, Han J
PloS one 2014;9(4):e94634

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The JNK antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human JNK. This antibody recognizes human, mouse antigen. The JNK antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 24164-1-AP.pdf

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