Antibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 66210-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- JNK antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated JNK antibody (Cat. #66210-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1A12E1
- Vial size
- 20ul, 150ul
Submitted references Enterococcus faecium HDRsEf1 inhibits Lipopolysaccharide-induced downregulation of zona occludens -1 expression via toll-like receptor 2/4-mediated c-Jun N-terminal kinase/activator protein-1 signalling pathways.
SPARC Aggravates Blood-Brain Barrier Disruption via Integrin αVβ3/MAPKs/MMP-9 Signaling Pathway after Subarachnoid Hemorrhage.
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts.
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
The Anti-Inflammatory Effect of a Combination of Five Compounds From Five Chinese Herbal Medicines Used in the Treatment of COPD.
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect.
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Maternal organic selenium supplementation alleviates LPS induced inflammation, autophagy and ER stress in the thymus and spleen of offspring piglets by improving the expression of selenoproteins.
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Collagen Vitrigel Membrane-Coated Nylon Line Prevents Stenosis After Conization of the Cervix Uteri.
Reticulocalbin 1 is required for proliferation and migration of non-small cell lung cancer cells regulated by osteoblast-conditioned medium.
1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway.
NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells.
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.
Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway.
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Extract of Schisandra chinensis fruit protects against metabolic dysfunction in high-fat diet induced obese mice via FXR activation.
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition.
Beehive-Inspired Macroporous SERS Probe for Cancer Detection through Capturing and Analyzing Exosomes in Plasma.
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis.
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway.
Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury.
Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.
Involvement of JNK signaling in IL4-induced M2 macrophage polarization.
Liu L, Li Y, He Y, Wang Z, Zhao H, Jin X, Shi D, Wang X
Journal of applied microbiology 2022 Jan;132(1):605-617
Journal of applied microbiology 2022 Jan;132(1):605-617
SPARC Aggravates Blood-Brain Barrier Disruption via Integrin αVβ3/MAPKs/MMP-9 Signaling Pathway after Subarachnoid Hemorrhage.
Okada T, Suzuki H, Travis ZD, Altay O, Tang J, Zhang JH
Oxidative medicine and cellular longevity 2021;2021:9739977
Oxidative medicine and cellular longevity 2021;2021:9739977
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.
Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497
Oxidative medicine and cellular longevity 2021;2021:6670497
Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts.
Li T, Jiang G, Hu X, Yang D, Tan T, Gao Z, Chen Z, Xiang C, Li S, Ouyang Z, Guo X
Frontiers in pharmacology 2021;12:789552
Frontiers in pharmacology 2021;12:789552
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819
Frontiers in pharmacology 2021;12:709819
The Anti-Inflammatory Effect of a Combination of Five Compounds From Five Chinese Herbal Medicines Used in the Treatment of COPD.
Li J, Zhao P, Tian Y, Li K, Zhang L, Guan Q, Mei X, Qin Y
Frontiers in pharmacology 2021;12:709702
Frontiers in pharmacology 2021;12:709702
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, Wang Z, Huang J, Wang W, Liu T, Xue W, Chen G
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect.
Chang XM, Xiao F, Pan Q, Wang XX, Guo LX
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Sep 1;25(5):425-437
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Sep 1;25(5):425-437
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Wang L, Chen X, Wang L, Wang S, Li W, Liu Y, Zhang J
IUBMB life 2021 Nov;73(11):1378-1391
IUBMB life 2021 Nov;73(11):1378-1391
Maternal organic selenium supplementation alleviates LPS induced inflammation, autophagy and ER stress in the thymus and spleen of offspring piglets by improving the expression of selenoproteins.
Ding D, Mou D, Zhao L, Jiang X, Che L, Fang Z, Xu S, Lin Y, Zhuo Y, Li J, Huang C, Zou Y, Li L, Wu, Feng B
Food & function 2021 Nov 15;12(22):11214-11228
Food & function 2021 Nov 15;12(22):11214-11228
Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.
Zhang X, Li F, Zhou Y, Mao F, Lin Y, Shen S, Li Y, Zhang S, Sun Q
Cell death & disease 2021 Jun 18;12(7):627
Cell death & disease 2021 Jun 18;12(7):627
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.
Li Q, Li S, Xu C, Zhao J, Hou L, Jiang F, Zhu Z, Wang Y, Tian L
Cell biology and toxicology 2021 Jul 31;
Cell biology and toxicology 2021 Jul 31;
Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.
Liu H, Bian W, Yang D, Yang M, Luo H
Life sciences 2021 Jan 1;264:118667
Life sciences 2021 Jan 1;264:118667
Collagen Vitrigel Membrane-Coated Nylon Line Prevents Stenosis After Conization of the Cervix Uteri.
Hashiguchi M, Takezawa T, Nagase K, Tayama-Abe M, Matsuhisa F, Kitajima S, Morito S, Yamaji K, Futamata M, Sakata Y, Akutagawa T, Yokoyama M, Toda S, Aoki S
Tissue engineering. Part A 2021 Dec;27(23-24):1480-1489
Tissue engineering. Part A 2021 Dec;27(23-24):1480-1489
Reticulocalbin 1 is required for proliferation and migration of non-small cell lung cancer cells regulated by osteoblast-conditioned medium.
Fu H, Chen R, Wang Y, Xu Y, Xia C, Zhang B
Journal of cellular and molecular medicine 2021 Dec;25(24):11198-11211
Journal of cellular and molecular medicine 2021 Dec;25(24):11198-11211
1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway.
Yu B, Jin XQ, Yu WY, Dong YY, Ying HZ, Yu CH
International immunopharmacology 2021 Dec;101(Pt A):108339
International immunopharmacology 2021 Dec;101(Pt A):108339
NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells.
Yuan L, Zhu Y, Huang S, Lin L, Jiang X, Chen S
Journal of microbiology (Seoul, Korea) 2021 Aug;59(8):771-781
Journal of microbiology (Seoul, Korea) 2021 Aug;59(8):771-781
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
He X, Gao F, Hou J, Li T, Tan J, Wang C, Liu X, Wang M, Liu H, Chen Y, Yu Z, Yang M
The Journal of biological chemistry 2021 Aug;297(2):101002
The Journal of biological chemistry 2021 Aug;297(2):101002
Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.
Zheng X, Liu H, Ma M, Ji J, Zhu F, Sun L
Archives of pharmacal research 2021 Apr;44(4):427-438
Archives of pharmacal research 2021 Apr;44(4):427-438
Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway.
Long Y, Xiang Y, Liu S, Zhang Y, Wan J, Yang Q, Cui M, Ci Z, Li N, Peng W
Mediators of inflammation 2020;2020:8414062
Mediators of inflammation 2020;2020:8414062
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D, Yang L
American journal of cancer research 2020;10(7):2083-2099
American journal of cancer research 2020;10(7):2083-2099
Extract of Schisandra chinensis fruit protects against metabolic dysfunction in high-fat diet induced obese mice via FXR activation.
Gu M, Song H, Li Y, Jiang Y, Zhang Y, Tang Z, Ji G, Huang C
Phytotherapy research : PTR 2020 Nov;34(11):3063-3077
Phytotherapy research : PTR 2020 Nov;34(11):3063-3077
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
Liu C, Han X, Yu PJ, Chen LZ, Xue W, Liu XH
Bioorganic chemistry 2020 Mar;96:103597
Bioorganic chemistry 2020 Mar;96:103597
Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition.
Xiao X, Liu P, Li D, Xia Z, Wang P, Zhang X, Liu M, Liao L, Jiao B, Ren R
Journal of hematology & oncology 2020 Jun 18;13(1):80
Journal of hematology & oncology 2020 Jun 18;13(1):80
Beehive-Inspired Macroporous SERS Probe for Cancer Detection through Capturing and Analyzing Exosomes in Plasma.
Dong S, Wang Y, Liu Z, Zhang W, Yi K, Zhang X, Zhang X, Jiang C, Yang S, Wang F, Xiao X
ACS applied materials & interfaces 2020 Jan 29;12(4):5136-5146
ACS applied materials & interfaces 2020 Jan 29;12(4):5136-5146
Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.
He J, Huang Z, He M, Liao J, Zhang Q, Wang S, Xie L, Ouyang L, Koeffler HP, Yin D, Liu A
Molecular cancer 2020 Jan 28;19(1):17
Molecular cancer 2020 Jan 28;19(1):17
Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis.
Luo J, Yang C, Luo X, Yang Y, Li J, Song B, Zhao J, Li L
Life sciences 2020 Aug 1;254:117590
Life sciences 2020 Aug 1;254:117590
Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Liu K, Lu R, Zhao Q, Du J, Li Y, Zheng M, Zhang S
Medical oncology (Northwood, London, England) 2019 Nov 16;37(1):6
Medical oncology (Northwood, London, England) 2019 Nov 16;37(1):6
MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway.
Lu L, Liu Q, Wang P, Wu Y, Liu X, Weng C, Fang X, Li B, Cao X, Mao H, Wang L, Guan M, Wang W, Liu G
BMC cancer 2019 Mar 8;19(1):209
BMC cancer 2019 Mar 8;19(1):209
Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury.
Su L, Jiang X, Yang C, Zhang J, Chen B, Li Y, Yao S, Xie Q, Gomez H, Murugan R, Peng Z
The Journal of biological chemistry 2019 Dec 13;294(50):19395-19404
The Journal of biological chemistry 2019 Dec 13;294(50):19395-19404
Cathelicidin-WA attenuates LPS-induced inflammation and redox imbalance through activation of AMPK signaling.
Wu W, Wang S, Liu Q, Wang X, Shan T, Wang Y
Free radical biology & medicine 2018 Dec;129:338-353
Free radical biology & medicine 2018 Dec;129:338-353
Involvement of JNK signaling in IL4-induced M2 macrophage polarization.
Hao J, Hu Y, Li Y, Zhou Q, Lv X
Experimental cell research 2017 Aug 15;357(2):155-162
Experimental cell research 2017 Aug 15;357(2):155-162
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 66210-1-Ig( JNK Antibody) at dilution of 1:1000
- Validation comment
- WB