Ab111518

antibody from Aladdin Scientific

Targeting: MAPK8 JNK, JNK1, PRKM8, SAPK1

Immunocytochemistry

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Product number: Ab111518 - Provider product page
Provider: Aladdin Scientific
Product name: Recombinant JNK1 Antibody
Antibody type: Recombinant
Description: Rabbit anti Human JNK1 Antibody, Recombinant, could be used for WB and so on.Application:WB: 1/500 - 1/1000ICC/IF: 1/50-1/200 Protein FunctionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.Post-translationalDually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: AA 325-343
Vial size: 100_l,10_l,1ml,50_l
Concentration: 1 mg/ml
Storage: Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

MAPK8 protein structure - Ab111518 shown in red.