BS8308

antibody from Bioworld Technology, Inc
Targeting: IL13RA1 CD213a1, IL-13Ra, NR4
Provider product page for BS8308
Western blot
Immunohistochemistry

Antibody data

Product number
BS8308 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL13RA1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL13RA1.
Description
The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13RÏ«1 and 2. IL-13RÏ«1 exists as a heterodimer of IL-13RÏ«1 and IL-4RÏ« as a signaling subunit, whereas IL-13RÏ«2 acts as a decoy receptor for IL-13. Furthermore, TNFÏ« or IL-4 stimulation induces IL-13RÏ«2 upregulation, while IL-13RÏ«1 is constitutively expressed. Cell surface localization of IL-13RÏ«2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13RÏ«1 expression is predominant in B cells, monocytes and T cells, whereas IL-13RÏ«2 expression is highest in glioma cells.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL13RA1 protein structure - BS8308 shown in red.