Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11955-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11955-1-AP, RRID:AB_2117529
- Product name
- HELLS antibody
- Antibody type
- Polyclonal
- Description
- HELLS antibody (Cat. #11955-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.
Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging.
Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.
HELLS serves as a poor prognostic biomarker and its downregulation reserves the malignant phenotype in pancreatic cancer.
Adenovirus Remodeling of the Host Proteome and Host Factors Associated with Viral Genomes.
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function.
Vukic M, Chouaref J, Della Chiara V, Dogan S, Ratner F, Hogenboom JZM, Epp TA, Chawengsaksophak K, Vonk KKD, Breukel C, Ariyurek Y, San Leon Granado D, Kloet SL, Daxinger L
Science advances 2024 Feb 9;10(6):eadk3384
Science advances 2024 Feb 9;10(6):eadk3384
Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging.
Huang J, Chen P, Jia L, Li T, Yang X, Liang Q, Zeng Y, Liu J, Wu T, Hu W, Kee K, Zeng H, Liang X, Zhou C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2301538
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2301538
Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
Cousu C, Mulot E, De Smet A, Formichetti S, Lecoeuche D, Ren J, Muegge K, Boulard M, Weill JC, Reynaud CA, Storck S
Nature communications 2023 Sep 14;14(1):5695
Nature communications 2023 Sep 14;14(1):5695
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.
Mandemaker IK, Fessler E, Corujo D, Kotthoff C, Wegerer A, Rouillon C, Buschbeck M, Jae LT, Mattiroli F, Ladurner AG
Cell reports 2023 Oct 31;42(10):113300
Cell reports 2023 Oct 31;42(10):113300
HELLS serves as a poor prognostic biomarker and its downregulation reserves the malignant phenotype in pancreatic cancer.
Wang FJ, Jing YH, Cheng CS, Cao ZQ, Jiao JY, Chen Z
BMC medical genomics 2021 Jul 27;14(1):189
BMC medical genomics 2021 Jul 27;14(1):189
Adenovirus Remodeling of the Host Proteome and Host Factors Associated with Viral Genomes.
Dybas JM, Lum KK, Kulej K, Reyes ED, Lauman R, Charman M, Purman CE, Steinbock RT, Grams N, Price AM, Mendoza L, Garcia BA, Weitzman MD
mSystems 2021 Aug 31;:e0046821
mSystems 2021 Aug 31;:e0046821
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Yang X, Miao BS, Wei CY, Dong RZ, Gao PT, Zhang XY, Lu JC, Gao C, Wang XY, Sun HC, Zhou J, Fan J, Ke AW, Shi GM, Cai JB
Cancer science 2019 Jul;110(7):2133-2144
Cancer science 2019 Jul;110(7):2133-2144
Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.
Wu H, Thijssen PE, de Klerk E, Vonk KK, Wang J, den Hamer B, Aytekin C, van der Maarel SM, Daxinger L
Human molecular genetics 2016 Sep 15;25(18):4041-4051
Human molecular genetics 2016 Sep 15;25(18):4041-4051
Lsh regulates LTR retrotransposon repression independently of Dnmt3b function.
Dunican DS, Cruickshanks HA, Suzuki M, Semple CA, Davey T, Arceci RJ, Greally J, Adams IR, Meehan RR
Genome biology 2013 Dec 24;14(12):R146
Genome biology 2013 Dec 24;14(12):R146
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11955-1-AP(HELLS antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using HELLS antibody 11955-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 11955-1-AP(HELLS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue