NBP2-47810-0.1mg

antibody from Novus Biologicals

Targeting: MAP3K1 MAPKKK1, MEKK, MEKK1

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Immunocytochemistry

Flow cytometry

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Validation data

Product number: NBP2-47810-0.1mg - Provider product page
Provider: Novus Biologicals
Product name: Mouse Monoclonal MEKK1 Antibody
Antibody type: Monoclonal
Description: Protein A or G purified. Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NF B pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.
Reactivity: Human
Host: Mouse
Isotype: IgG
Vial size: 0.1 mg
Concentration: 1.0 mg/ml
Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

MAP3K1 protein structure - NBP2-47810-0.1mg shown in red.