ABIN2841754

antibody from antibodies-online

Targeting: NAB2 MADER

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN2841754

Provider

antibodies-online

Product name

anti-NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) (AA 109-138), (Center) antibody

Antibody type

Polyclonal

Description

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Reactivity

Human

Host

Rabbit

Epitope

AA 109-138, Center

Antibody clone number

RB18506

Vial size

80 μL

Storage

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

References

Submitted references

NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.

Srinivasan R, Mager GM, Ward RM, Mayer J, Svaren J
The Journal of biological chemistry 2006 Jun 2;281(22):15129-37

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Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop.

Kumbrink J, Gerlinger M, Johnson JP
The Journal of biological chemistry 2005 Dec 30;280(52):42785-93

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NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells.

Lucerna M, Mechtcheriakova D, Kadl A, Schabbauer G, Schäfer R, Gruber F, Koshelnick Y, Müller HD, Issbrücker K, Clauss M, Binder BR, Hofer E
The Journal of biological chemistry 2003 Mar 28;278(13):11433-40

Western blot

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB