354520

antibody from BioLegend

Targeting: NRP1 CD304, NRP, VEGF165R

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

354520

Provider

BioLegend

Proper citation

BioLegend Cat#354520, RRID:AB_2563078

Product name

Pacific Blue™ anti-human CD304 (Neuropilin-1)

Antibody type

Monoclonal

Antigen

CD304-Fc Fusion protein

Description

CD304, also known as neuropilin-1, BDCA-4 and VEGF165R, is a 140 kD type I transmembrane protein. Its extracellular region contains 2 CUB, 2 FV/FVIII, and one MAM domain; a soluble isoform is produced by alternative mRNA splicing. CD304 is involved in angiogenesis, neural development, and tumor metastasis. It's expressed by plasmacytoid dendritic cells, thymocytes, neurons, endothelium, and a subset of T_FH cells. CD304 is also expressed in several carcinomas, and a high expression of this molecule in prostate cancer correlates with a poor prognosis.

Reactivity

Human

Host

Mouse

Conjugate

Blue dye

Antibody clone number

12C2

Vial size

100 tests

Storage

2°C-8°C

Handling

Ambient RT

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood mononuclear cells were stained with CD303 PE and CD304 (clone 12C2) Pacific Blue™ (top) or mouse IgG2a, κ Pacific Blue™ isotype control (bottom). Data shown was gated on lymphocyte and monocyte populations.

Conjugate

Blue dye