60067-1-Ig

antibody from Proteintech Group

Targeting: NRP1 CD304, NRP, VEGF165R

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

60067-1-Ig

Provider

Proteintech Group

Proper citation

Proteintech Cat#60067-1-Ig, RRID:AB_2150840

Product name

Neuropilin 1 antibody

Antibody type

Monoclonal

Description

Neuropilin 1 antibody (Cat. #60067-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig and has been validated for the following applications: FC, IF, WB,ELISA.

Reactivity

Human, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2H3F6

Vial size

20ul, 150ul

References

Submitted references

Tumor-penetrating iRGD facilitates penetration of poly(floxuridine-ketal)-based nanomedicine for enhanced pancreatic cancer therapy.

Li X, Zhong H, Zheng S, Mu J, Yu N, Guo S
Journal of controlled release : official journal of the Controlled Release Society 2024 May;369:444-457

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Bispecific fibrous glue synergistically boosts vascular normalization and antitumor immunity for advanced renal carcinoma therapy.

Wu XH, Wang JQ, Wang MD, Xiao T, Wang Y, Niu JY, Wang L, Hou DY, Fu B, Liu Z, Wang H, Xu W
Biomaterials 2024 Jul;308:122550

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Tumor heterogeneity and tumor-microglia interactions in primary and recurrent IDH1-mutant gliomas.

Blanco-Carmona E, Narayanan A, Hernandez I, Nieto JC, Elosua-Bayes M, Sun X, Schmidt C, Pamir N, Özduman K, Herold-Mende C, Pagani F, Cominelli M, Taranda J, Wick W, von Deimling A, Poliani PL, Rehli M, Schlesner M, Heyn H, Turcan Ş
Cell reports. Medicine 2023 Nov 21;4(11):101249

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SARS-CoV2 entry factors are expressed in primary human glioblastoma and recapitulated in cerebral organoid models.

Suarez-Meade P, Watanabe F, Ruiz-Garcia H, Rafferty SB, Moniz-Garcia D, Schiapparelli PV, Jentoft ME, Imitola J, Quinones-Hinojosa A
Journal of neuro-oncology 2023 Jan;161(1):67-76

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NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

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Potassium Dehydroandrograpolide Succinate Targets NRP1 Mediated VEGFR2/VE-Cadherin Signaling Pathway to Promote Endothelial Barrier Repair.

Wang Z, Wu X, Li J, Guo Q, Jin Z, Li H, Liang B, Hu W, Xu H, Shi L, Yang L, Wang Y
International journal of molecular sciences 2023 Feb 4;24(4)

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Comprehensive analysis of cuproptosis-related immune biomarker signature to enhance prognostic accuracy in gastric cancer.

Li J, Yu T, Sun J, Zeng Z, Liu Z, Ma M, Zheng Z, He Y, Kang W
Aging 2023 Apr 7;15(7):2772-2796

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Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.

Chen M, Wang MH, Shen XG, Liu H, Zhang YY, Peng JM, Meng F, Wang TY, Bai YZ, Sun MX, Tian ZJ, Yin X, Cai XH, Tang YD
Journal of virology 2022 Oct 26;96(20):e0131822

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The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling.

Laplantine E, Chable-Bessia C, Oudin A, Swain J, Soria A, Merida P, Gourdelier M, Mestiri S, Besseghe I, Bremaud E, Neyret A, Lyonnais S, Favard C, Benaroch P, Hubert M, Schwartz O, Guerin M, Danckaert A, Del Nery E, Muriaux D, Weil R
iScience 2022 Oct 21;25(10):105066

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The Expression Levels of SARS-CoV-2 Infection-Mediating Molecules Promoted by Interferon-γ and Tumor Necrosis Factor-α Are Downregulated by Hydrogen Sulfide.

Zhao X, Cao Y, Zhao E, Li T, Cong T, Gao Y, Zhang J
International journal of molecular sciences 2022 Nov 7;23(21)

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Expression of axon guidance ligands and their receptors in the cornea and trigeminal ganglia and their recovery after corneal epithelium injury.

Guaiquil VH, Xiao C, Lara D, Dimailig G, Zhou Q
Experimental eye research 2022 Jun;219:109054

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CMTM6 promotes cell proliferation and invasion in oral squamous cell carcinoma by interacting with NRP1.

Zheng Y, Wang C, Song A, Jiang F, Zhou J, Li G, Zhang W, Ye J, Ding X, Zhang W, Du Y, Zhang H, Wu H, Song X, Wu Y
American journal of cancer research 2020;10(6):1691-1709

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Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.

Ma LL, Guo LL, Luo Y, Liu GL, Lei Y, Jing FY, Zhang YL, Tong GH, Jing ZL, Shen L, Tang MS, Ding YQ, Deng YJ
Cell death & disease 2020 Mar 5;11(3):171

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Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma.

Morin E, Lindskog C, Johansson M, Egevad L, Sandström P, Harmenberg U, Claesson-Welsh L, Sjöberg E
The Journal of pathology 2020 Apr;250(4):387-396

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Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.

Koppers M, Cagnetta R, Shigeoka T, Wunderlich LC, Vallejo-Ramirez P, Qiaojin Lin J, Zhao S, Jakobs MA, Dwivedy A, Minett MS, Bellon A, Kaminski CF, Harris WA, Flanagan JG, Holt CE
eLife 2019 Nov 20;8

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RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.

Zhang L, Chen Y, Li C, Liu J, Ren H, Li L, Zheng X, Wang H, Han Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108772

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NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot.

Duran I, Tenney J, Warren CM, Sarukhanov A, Csukasi F, Skalansky M, Iruela-Arispe ML, Krakow D
American journal of medical genetics. Part A 2018 Mar;176(3):649-656

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Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy.

Qiu Y, Yu Q, Liu Y, Tang J, Wang X, Lu Z, Xu Z, He Q
Pharmaceutical research 2018 Apr 26;35(7):130

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Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.

Saad S, Dharmapatni AASSK, Crotti TN, Cantley MD, Algate K, Findlay DM, Atkins GJ, Haynes DR
Acta biomaterialia 2016 Jan;30:311-318

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MiR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1.

Liu C, Wang Z, Wang Y, Gu W
Molecular and cellular biochemistry 2015 Jan;398(1-2):115-22

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human blood tissue were subjected to SDS PAGE followed by western blot with 60067-1-Ig(NRP1 antibody) at dilution of 1:500

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Confocal immunofluorescent analysis of human embronic stem cells with 60067-1-Ig at dilution of 1:100. DAPI was used to stain the cell nuclei (blue) at a concentration of 1ug/ml. This photo is the merge of PE and DAPI. (40X)

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 60067-1-Ig(NRP1 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 60067-1-Ig(NRP1 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue